JP2020511136A5 - - Google Patents
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- JP2020511136A5 JP2020511136A5 JP2019550246A JP2019550246A JP2020511136A5 JP 2020511136 A5 JP2020511136 A5 JP 2020511136A5 JP 2019550246 A JP2019550246 A JP 2019550246A JP 2019550246 A JP2019550246 A JP 2019550246A JP 2020511136 A5 JP2020511136 A5 JP 2020511136A5
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022097950A JP7465306B2 (ja) | 2017-03-17 | 2022-06-17 | 免疫調節性融合タンパク質およびその使用 |
| JP2024000159A JP2024019732A (ja) | 2017-03-17 | 2024-01-04 | 免疫調節性融合タンパク質およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762473282P | 2017-03-17 | 2017-03-17 | |
| US62/473,282 | 2017-03-17 | ||
| US201862629663P | 2018-02-12 | 2018-02-12 | |
| US62/629,663 | 2018-02-12 | ||
| PCT/US2018/022998 WO2018170475A1 (en) | 2017-03-17 | 2018-03-16 | Immunomodulatory fusion proteins and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022097950A Division JP7465306B2 (ja) | 2017-03-17 | 2022-06-17 | 免疫調節性融合タンパク質およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020511136A JP2020511136A (ja) | 2020-04-16 |
| JP2020511136A5 true JP2020511136A5 (OSRAM) | 2021-04-15 |
Family
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550246A Pending JP2020511136A (ja) | 2017-03-17 | 2018-03-16 | 免疫調節性融合タンパク質およびその使用 |
| JP2022097950A Active JP7465306B2 (ja) | 2017-03-17 | 2022-06-17 | 免疫調節性融合タンパク質およびその使用 |
| JP2024000159A Withdrawn JP2024019732A (ja) | 2017-03-17 | 2024-01-04 | 免疫調節性融合タンパク質およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022097950A Active JP7465306B2 (ja) | 2017-03-17 | 2022-06-17 | 免疫調節性融合タンパク質およびその使用 |
| JP2024000159A Withdrawn JP2024019732A (ja) | 2017-03-17 | 2024-01-04 | 免疫調節性融合タンパク質およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11725210B2 (OSRAM) |
| EP (1) | EP3595706A1 (OSRAM) |
| JP (3) | JP2020511136A (OSRAM) |
| CN (2) | CN119409836A (OSRAM) |
| AU (1) | AU2018236461B2 (OSRAM) |
| CA (1) | CA3055784A1 (OSRAM) |
| MX (2) | MX2019010812A (OSRAM) |
| WO (1) | WO2018170475A1 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107531805A (zh) * | 2015-03-05 | 2018-01-02 | 弗雷德哈钦森癌症研究中心 | 免疫调节融合蛋白及其用途 |
| AU2017379900B2 (en) | 2016-12-22 | 2024-12-05 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3596118B1 (en) | 2017-03-15 | 2024-08-21 | Cue Biopharma, Inc. | Combination of multimeric fusion polypeptides and immune checkpoint inhibitor for treating hpv-associated cancer |
| EP3595706A1 (en) | 2017-03-17 | 2020-01-22 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| WO2019051127A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | MULTIMER MODULATOR POLYPEPTIDE OF LYMPHOCYTE T HAVING CONJUGATION SITES AND METHODS OF USE THEREOF |
| KR20210073520A (ko) * | 2018-09-05 | 2021-06-21 | 포세이다 테라퓨틱스, 인크. | 동종이계 세포 조성물 및 이의 사용 방법 |
| CN113166226B (zh) * | 2018-09-28 | 2025-06-27 | 纪念斯隆-凯特琳癌症中心 | 表达显性负性fas的免疫应答细胞及其用途 |
| GB2569692A (en) * | 2018-10-30 | 2019-06-26 | Tc Biopharm Ltd | T cell antigen receptor chimera |
| WO2020132368A1 (en) * | 2018-12-19 | 2020-06-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof |
| TWI856047B (zh) * | 2018-12-19 | 2024-09-21 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| US12419913B2 (en) | 2019-02-08 | 2025-09-23 | Dna Twopointo, Inc. | Modification of CAR-T cells |
| KR20220030205A (ko) * | 2019-02-08 | 2022-03-10 | 디앤에이 투포인토 인크. | 면역 세포의 트랜스포존 기반 변형 |
| EP3999079A4 (en) * | 2019-07-19 | 2024-04-03 | Memorial Sloan Kettering Cancer Center | Fusion polypeptide for immunotherapy |
| AU2020342544A1 (en) * | 2019-09-05 | 2022-03-24 | Poseida Therapeutics, Inc. | Allogeneic cell compositions and methods of use |
| WO2021051195A1 (en) * | 2019-09-16 | 2021-03-25 | Mcmaster University | Chimeric costimulatory receptors and methods and uses thereof |
| CN110790842B (zh) * | 2019-11-25 | 2021-03-30 | 贵州康钦承平生物科技有限公司 | 一种FasL-CAR融合蛋白和表达融合蛋白的T细胞及其制备方法和应用 |
| CN115279389A (zh) * | 2020-01-06 | 2022-11-01 | 纪念斯隆-凯特琳癌症中心 | 新型显性负性Fas多肽、包含其的细胞及其用途 |
| EP4118107A1 (en) * | 2020-03-11 | 2023-01-18 | Poseida Therapeutics, Inc. | Chimeric stimulatory receptors and methods of use in t cell activation and differentiation |
| US20230133554A1 (en) | 2020-04-09 | 2023-05-04 | Autolus Limited | Molecule |
| GB202101491D0 (en) | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| US20230113183A1 (en) * | 2020-04-09 | 2023-04-13 | Autolus Limited | Cell |
| EP4149534A4 (en) | 2020-05-12 | 2024-09-04 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING T CELLS AND METHODS OF USE THEREOF |
| BR112022023371A2 (pt) * | 2020-05-22 | 2022-12-20 | Chongqing Prec Biotech Co Ltd | Proteína de fusão para reversão do microambiente tumoral, vetor de expressão, célula imune, receptor de antígeno quimérico resistente à imunossupressão tumoral, sequência de ácido nucleico, método para preparar uma célula imune, composição farmacêutica, e, uso da composição farmacêutica |
| IL299886A (en) | 2020-07-17 | 2023-03-01 | Instil Bio Uk Ltd | Receptors that provide targeted costimulation for host cell therapy |
| WO2022056014A1 (en) | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| EP4355340A4 (en) | 2021-06-16 | 2025-05-21 | Instil Bio, Inc. | RECEPTORS FOR TARGETED COSTIMULATION FOR ADOPTIVE CELL THERAPY |
| WO2023288278A1 (en) | 2021-07-16 | 2023-01-19 | Instil Bio (Uk) Limited | Chimeric molecules providing targeted costimulation for adoptive cell therapy |
| CN113621077B (zh) * | 2021-09-02 | 2023-01-31 | 山东大学 | 一种tim-3/cd28融合蛋白及所述融合蛋白修饰的car-t细胞 |
| WO2023094527A1 (en) * | 2021-11-25 | 2023-06-01 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Cd95 polypeptides |
| EP4476246A2 (en) * | 2022-02-07 | 2024-12-18 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Recombinant proteins that stimulate an immune response in the presence of naturally inhibitory ligand binding |
| EP4499680A1 (en) * | 2022-03-29 | 2025-02-05 | Allogene Therapeutics, Inc. | Chimeric switch receptors for the conversion of immunesuppressive signals to costimulatory signals |
| CN119730872A (zh) * | 2022-05-23 | 2025-03-28 | 艾费尼T医疗公司 | 对新抗原具特异性的结合蛋白与工程化细胞和其用途 |
| EP4293040A1 (en) | 2022-06-19 | 2023-12-20 | ETH Zurich | Cell line for engineering cytokine receptors |
| WO2024046468A1 (en) * | 2022-09-02 | 2024-03-07 | Nanjing Legend Biotech Co., Ltd. | Fusion proteins targeting lysosomal degradation pathway |
| WO2024117781A1 (ko) * | 2022-11-29 | 2024-06-06 | (주) 테라베스트 | Cd137 세포외 도메인을 포함하는 융합단백질, 이를 발현하는 면역세포 및 이의 용도 |
| WO2024193714A1 (zh) * | 2023-03-23 | 2024-09-26 | 科济生物医药（上海）有限公司 | 细胞免疫疗法的组合物和方法 |
| WO2025006795A1 (en) * | 2023-06-30 | 2025-01-02 | Board Of Regents, The University Of Texas System | Tsyn-seq: a t cell synapse-based tumor antigen identification platform |
| WO2025081123A1 (en) | 2023-10-12 | 2025-04-17 | Fred Hutchinson Cancer Center | Methods and compositions for improving t cell immunotherapy |
| WO2025117773A2 (en) * | 2023-11-30 | 2025-06-05 | Affini-T Therapeutics, Inc. | Compositions and methods for treating neoplasia |
| EP4599843A1 (en) | 2024-02-09 | 2025-08-13 | Fundació Institut de recerca de l'Hospital de la Santa Creu i Sant Pau | Car and modified cd200r combination |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1999A (en) | 1841-03-12 | Improvement in seed-planters | ||
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| ES2229236T3 (es) | 1994-01-11 | 2005-04-16 | Dyax Corporation | Inhibidores de la plasmina humana derivados de los dominios de kunitz. |
| WO1996013584A1 (en) | 1994-11-01 | 1996-05-09 | Targeted Genetics Corporation | Chimeric receptors for the generation of selectively-activatable th-independent cytotoxic t cells |
| US5712149A (en) | 1995-02-03 | 1998-01-27 | Cell Genesys, Inc. | Chimeric receptor molecules for delivery of co-stimulatory signals |
| AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
| JP5563194B2 (ja) | 2004-06-29 | 2014-07-30 | イムノコア リミテッド | 改変ｔ細胞レセプターを発現する細胞 |
| AU2006204459B2 (en) | 2005-01-05 | 2012-11-01 | F-Star Therapeutics Limited | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
| GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
| EP1829895A1 (en) | 2006-03-03 | 2007-09-05 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Bispecific molecule binding TLR9 and CD32 and comprising a T cell epitope for treatment of allergies |
| US8119772B2 (en) | 2006-09-29 | 2012-02-21 | California Institute Of Technology | MART-1 T cell receptors |
| JP2010539915A (ja) | 2007-09-24 | 2010-12-24 | ユニバーシティ・オブ・チューリッヒ | 設計されたアルマジロリピートタンパク質 |
| WO2012012695A2 (en) | 2010-07-23 | 2012-01-26 | Fred Hutchinson Cancer Research Center | A method for the treatment of obesity |
| AU2011309689B2 (en) | 2010-09-28 | 2015-01-15 | Hadasit Medical Research Services & Development Ltd. | Compositions and methods for treatment of hematological malignancies |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| KR101976882B1 (ko) | 2011-03-23 | 2019-05-09 | 프레드 헛친슨 켄서 리서치 센터 | 세포 면역요법용 방법 및 조성물 |
| NZ723731A (en) | 2011-04-08 | 2020-05-29 | Baylor College Medicine | Reversing the effects of the tumor microenvironment using chimeric cytokine receptors |
| PE20141520A1 (es) | 2011-07-29 | 2014-11-17 | Univ Pennsylvania | Receptores coestimuladores de cambio |
| KR101471647B1 (ko) | 2011-10-26 | 2014-12-11 | 국립암센터 | 변이 ｃｔｌａ4 유전자 이입 ｔ 세포 및 이를 포함하는 항암 면역치료용 조성물 |
| JP6850528B2 (ja) | 2012-02-13 | 2021-03-31 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 二重特異性キメラ抗原受容体およびその治療的使用 |
| WO2013192294A1 (en) * | 2012-06-20 | 2013-12-27 | Boston 3T Biotechnologies, Inc. | Cellular therapies for treating and preventing cancers and other immune system disorders |
| CA2896989A1 (en) | 2013-01-01 | 2014-07-10 | Kahr Medical Ltd. | Stable form of signal converting protein fusion proteins, and methods of use and preparation thereof |
| EP2943565B1 (en) | 2013-01-14 | 2018-03-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for delivery of immune cells to treat un-resectable or non-resected tumor cells and tumor relapse |
| CN103965361B (zh) | 2013-02-06 | 2018-10-30 | 上海细胞治疗工程技术研究中心集团有限公司 | 一种t细胞信号的嵌合分子转换器及其用途 |
| WO2014172584A1 (en) | 2013-04-17 | 2014-10-23 | Baylor College Of Medicine | IMMUNOSUPPRESSIVE TGF-β SIGNAL CONVERTER |
| CN107109420A (zh) | 2014-07-21 | 2017-08-29 | 诺华股份有限公司 | 使用cll－1嵌合抗原受体的癌症治疗 |
| BR112017001242A2 (pt) | 2014-07-21 | 2017-12-05 | Novartis Ag | tratamento de câncer usando um receptor antigênico quimérico a cd33 |
| WO2016014565A2 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
| JP6712261B2 (ja) | 2014-08-04 | 2020-06-24 | フレッド ハッチンソン キャンサー リサーチ センター | Ｗｔ−１に特異的なｔ細胞免疫治療 |
| WO2016024021A1 (en) | 2014-08-15 | 2016-02-18 | Merck Patent Gmbh | Sirp-alpha immunoglobulin fusion proteins |
| HRP20240357T1 (hr) | 2014-12-24 | 2024-06-07 | Autolus Limited | Stanica |
| JP6734283B2 (ja) | 2015-01-21 | 2020-08-05 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子治療用ポイントオブケア及び／又はポータブルプラットフォーム |
| CN107531805A (zh) | 2015-03-05 | 2018-01-02 | 弗雷德哈钦森癌症研究中心 | 免疫调节融合蛋白及其用途 |
| PT3310805T (pt) | 2015-06-19 | 2021-05-19 | Kobold Sebastian | Proteínas de fusão pd-1-cd28 e a sua utilização em medicina |
| WO2017088012A1 (en) | 2015-11-27 | 2017-06-01 | Cartherics Pty. Ltd. | Genetically modified cells and uses thereof |
| EP3394092A1 (en) | 2015-12-23 | 2018-10-31 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| US10188749B2 (en) | 2016-04-14 | 2019-01-29 | Fred Hutchinson Cancer Research Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| JP7198670B2 (ja) | 2016-04-20 | 2023-01-04 | フレッド ハッチンソン キャンサー センター | 免疫調整性ｉｌ２ｒ融合タンパク質およびその使用 |
| EP3595706A1 (en) | 2017-03-17 | 2020-01-22 | Fred Hutchinson Cancer Research Center | Immunomodulatory fusion proteins and uses thereof |
| WO2019061012A1 (zh) | 2017-09-26 | 2019-04-04 | 南京凯地生物科技有限公司 | 靶向cd47的特异性嵌合抗原受体t细胞的制备及其应用 |
| CN110330567B (zh) | 2019-07-02 | 2020-11-06 | 南京凯地生物科技有限公司 | 双特异性嵌合抗原受体t细胞，其制备方法和应用 |
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2018
- 2018-03-16 EP EP18716423.1A patent/EP3595706A1/en active Pending
- 2018-03-16 US US16/494,729 patent/US11725210B2/en active Active
- 2018-03-16 MX MX2019010812A patent/MX2019010812A/es unknown
- 2018-03-16 CA CA3055784A patent/CA3055784A1/en active Pending
- 2018-03-16 CN CN202411496477.3A patent/CN119409836A/zh active Pending
- 2018-03-16 AU AU2018236461A patent/AU2018236461B2/en active Active
- 2018-03-16 CN CN201880030106.2A patent/CN110621335B/zh active Active
- 2018-03-16 WO PCT/US2018/022998 patent/WO2018170475A1/en not_active Ceased
- 2018-03-16 JP JP2019550246A patent/JP2020511136A/ja active Pending
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2019
- 2019-09-11 MX MX2024000006A patent/MX2024000006A/es unknown
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2022
- 2022-06-17 JP JP2022097950A patent/JP7465306B2/ja active Active
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2023
- 2023-06-21 US US18/339,197 patent/US12365906B2/en active Active
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- 2024-01-04 JP JP2024000159A patent/JP2024019732A/ja not_active Withdrawn
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