JP2017527310A5 - - Google Patents
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- JP2017527310A5 JP2017527310A5 JP2017533170A JP2017533170A JP2017527310A5 JP 2017527310 A5 JP2017527310 A5 JP 2017527310A5 JP 2017533170 A JP2017533170 A JP 2017533170A JP 2017533170 A JP2017533170 A JP 2017533170A JP 2017527310 A5 JP2017527310 A5 JP 2017527310A5
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- chimeric receptor
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- pharmaceutical composition
- receptor
- cell
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- 108700010039 chimeric receptor Proteins 0.000 claims 22
- 210000002865 immune cell Anatomy 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 8
- 230000011664 signaling Effects 0.000 claims 8
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 7
- 101100334515 Homo sapiens FCGR3A gene Proteins 0.000 claims 5
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 5
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 claims 5
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 5
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 claims 5
- 230000000139 costimulatory effect Effects 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000001086 cytosolic effect Effects 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 108020001756 ligand binding domains Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000013603 viral vector Substances 0.000 claims 4
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000003979 eosinophil Anatomy 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 210000002540 macrophage Anatomy 0.000 claims 3
- 210000000822 natural killer cell Anatomy 0.000 claims 3
- 210000000440 neutrophil Anatomy 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- -1 CD3ζ Proteins 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 102100026122 High affinity immunoglobulin gamma Fc receptor I Human genes 0.000 claims 2
- 101000913074 Homo sapiens High affinity immunoglobulin gamma Fc receptor I Proteins 0.000 claims 2
- 101000917826 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-a Proteins 0.000 claims 2
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 claims 2
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001177 retroviral effect Effects 0.000 claims 2
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 1
- 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 101000964894 Bos taurus 14-3-3 protein zeta/delta Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 102100034459 Hepatitis A virus cellular receptor 1 Human genes 0.000 claims 1
- 102100022132 High affinity immunoglobulin epsilon receptor subunit gamma Human genes 0.000 claims 1
- 108091010847 High affinity immunoglobulin epsilon receptor subunit gamma Proteins 0.000 claims 1
- 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims 1
- 101000878602 Homo sapiens Immunoglobulin alpha Fc receptor Proteins 0.000 claims 1
- 101000917824 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor II-b Proteins 0.000 claims 1
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims 1
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims 1
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims 1
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims 1
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 108010073816 IgE Receptors Proteins 0.000 claims 1
- 102000009438 IgE Receptors Human genes 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102100038005 Immunoglobulin alpha Fc receptor Human genes 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 claims 1
- 101100341510 Mus musculus Itgal gene Proteins 0.000 claims 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 claims 1
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000548 alemtuzumab Drugs 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 230000003190 augmentative effect Effects 0.000 claims 1
- 229960004669 basiliximab Drugs 0.000 claims 1
- 229960003270 belimumab Drugs 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 229960000455 brentuximab vedotin Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 229960001838 canakinumab Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960003115 certolizumab pegol Drugs 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 230000004940 costimulation Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229960002806 daclizumab Drugs 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000003389 potentiating effect Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 229960001612 trastuzumab emtansine Drugs 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462047916P | 2014-09-09 | 2014-09-09 | |
| US62/047,916 | 2014-09-09 | ||
| PCT/US2015/049126 WO2016040441A1 (en) | 2014-09-09 | 2015-09-09 | Chimeric receptors and uses thereof in immune therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527310A JP2017527310A (ja) | 2017-09-21 |
| JP2017527310A5 true JP2017527310A5 (OSRAM) | 2018-10-18 |
Family
ID=54151414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017533170A Pending JP2017527310A (ja) | 2014-09-09 | 2015-09-09 | キメラ受容体および免疫療法におけるその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20180133252A9 (OSRAM) |
| EP (1) | EP3191507A1 (OSRAM) |
| JP (1) | JP2017527310A (OSRAM) |
| KR (1) | KR20170073593A (OSRAM) |
| CN (1) | CN107074969A (OSRAM) |
| AU (1) | AU2015315199B2 (OSRAM) |
| BR (1) | BR112017004675A2 (OSRAM) |
| CA (1) | CA2972714A1 (OSRAM) |
| IL (1) | IL250828A0 (OSRAM) |
| MA (1) | MA40595A (OSRAM) |
| MX (1) | MX2017003062A (OSRAM) |
| SG (2) | SG10201902168PA (OSRAM) |
| WO (1) | WO2016040441A1 (OSRAM) |
Families Citing this family (78)
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| US9512194B2 (en) | 2012-01-27 | 2016-12-06 | The Board Of Trustees Of The Leland Stanford Junior University | Modified IL-13 polypeptides |
| JP6445434B2 (ja) | 2012-08-09 | 2018-12-26 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | スーパーカインおよびシンセカイン：新規かつ増強されたシグナル伝達活性を有する再利用されるサイトカイン |
| SG11201505858VA (en) | 2013-01-28 | 2015-09-29 | St Jude Childrens Res Hospital | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| US10144770B2 (en) | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| WO2015058018A1 (en) * | 2013-10-17 | 2015-04-23 | National University Of Singapore | Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors |
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
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| WO2017161333A1 (en) * | 2016-03-18 | 2017-09-21 | Unum Therapeutics | Modified chimeric receptors and uses thereof in immune therapy |
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| US20190284298A1 (en) * | 2016-07-19 | 2019-09-19 | Unum Therapeutics Inc. | Use of antibody-coupled t cell receptor (actr) with multiple anti-cancer antibodies in cancer treatment |
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| WO2018112266A1 (en) * | 2016-12-14 | 2018-06-21 | The Board Of Trustees Of The Leland Stanford Junior University | Il-13 superkine: immune cell targeting constructs and methods of use thereof |
| US11578115B2 (en) | 2017-01-10 | 2023-02-14 | The General Hospital Corporation | Chimeric antigen receptors based on alternative signal 1 domains |
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| WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
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| PL3006459T3 (pl) * | 2008-08-26 | 2022-01-17 | City Of Hope | Sposób i kompozycje dla wzmocnionego działania efektorowego komórek t przeciw guzowi nowotworowemu |
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| EP2483301A1 (en) * | 2009-10-01 | 2012-08-08 | The United States Of America, As Represented By The Secretary, Department of Health and Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
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| US10144770B2 (en) * | 2013-10-17 | 2018-12-04 | National University Of Singapore | Chimeric receptors and uses thereof in immune therapy |
| US20170151283A1 (en) * | 2014-05-23 | 2017-06-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating antibody resistance |
-
2015
- 2015-09-09 MX MX2017003062A patent/MX2017003062A/es unknown
- 2015-09-09 BR BR112017004675A patent/BR112017004675A2/pt not_active IP Right Cessation
- 2015-09-09 AU AU2015315199A patent/AU2015315199B2/en not_active Ceased
- 2015-09-09 US US15/509,133 patent/US20180133252A9/en not_active Abandoned
- 2015-09-09 CA CA2972714A patent/CA2972714A1/en not_active Abandoned
- 2015-09-09 JP JP2017533170A patent/JP2017527310A/ja active Pending
- 2015-09-09 KR KR1020177009209A patent/KR20170073593A/ko not_active Withdrawn
- 2015-09-09 MA MA040595A patent/MA40595A/fr unknown
- 2015-09-09 WO PCT/US2015/049126 patent/WO2016040441A1/en not_active Ceased
- 2015-09-09 SG SG10201902168PA patent/SG10201902168PA/en unknown
- 2015-09-09 EP EP15767396.3A patent/EP3191507A1/en not_active Withdrawn
- 2015-09-09 SG SG11201701775VA patent/SG11201701775VA/en unknown
- 2015-09-09 CN CN201580048652.5A patent/CN107074969A/zh active Pending
-
2017
- 2017-02-27 IL IL250828A patent/IL250828A0/en unknown
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