JP2018506981A5 - - Google Patents
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- JP2018506981A5 JP2018506981A5 JP2017544615A JP2017544615A JP2018506981A5 JP 2018506981 A5 JP2018506981 A5 JP 2018506981A5 JP 2017544615 A JP2017544615 A JP 2017544615A JP 2017544615 A JP2017544615 A JP 2017544615A JP 2018506981 A5 JP2018506981 A5 JP 2018506981A5
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- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- cdrs
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 12
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 210000004698 lymphocyte Anatomy 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 6
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100036466 Delta-like protein 3 Human genes 0.000 claims 3
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 claims 3
- 229940127276 delta-like ligand 3 Drugs 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 230000002463 transducing effect Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000002120 neuroendocrine carcinoma Diseases 0.000 claims 1
- 208000015347 renal cell adenocarcinoma Diseases 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562119793P | 2015-02-23 | 2015-02-23 | |
| US62/119,793 | 2015-02-23 | ||
| US201562241662P | 2015-10-14 | 2015-10-14 | |
| US62/241,662 | 2015-10-14 | ||
| US201662296560P | 2016-02-17 | 2016-02-17 | |
| US62/296,560 | 2016-02-17 | ||
| PCT/US2016/019192 WO2016138038A1 (en) | 2015-02-23 | 2016-02-23 | Anti-dll3 chimeric antigen receptors and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018506981A JP2018506981A (ja) | 2018-03-15 |
| JP2018506981A5 true JP2018506981A5 (enExample) | 2019-04-04 |
Family
ID=56789774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544615A Pending JP2018506981A (ja) | 2015-02-23 | 2016-02-23 | 抗ｄｌｌ３キメラ抗原受容体および使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20180044415A1 (enExample) |
| EP (1) | EP3261650A4 (enExample) |
| JP (1) | JP2018506981A (enExample) |
| KR (1) | KR20170120158A (enExample) |
| CN (1) | CN107405362A (enExample) |
| BR (1) | BR112017017927A2 (enExample) |
| CA (1) | CA2977502A1 (enExample) |
| CL (1) | CL2017002150A1 (enExample) |
| CO (1) | CO2017008804A2 (enExample) |
| CR (1) | CR20170436A (enExample) |
| DO (1) | DOP2017000199A (enExample) |
| EA (1) | EA201791884A1 (enExample) |
| EC (1) | ECSP17063327A (enExample) |
| HK (1) | HK1249405A1 (enExample) |
| IL (1) | IL254068A0 (enExample) |
| MA (1) | MA41613A (enExample) |
| MX (1) | MX2017010845A (enExample) |
| PE (1) | PE20171383A1 (enExample) |
| PH (1) | PH12017501521A1 (enExample) |
| SG (1) | SG11201706804SA (enExample) |
| TW (1) | TW201639887A (enExample) |
| WO (1) | WO2016138038A1 (enExample) |
| ZA (1) | ZA201705720B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| CA2986575A1 (en) | 2015-05-21 | 2016-11-24 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| CN108395482B (zh) | 2017-02-08 | 2021-02-05 | 西比曼生物科技（香港）有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| KR20190118172A (ko) | 2017-02-08 | 2019-10-17 | 드래곤플라이 쎄라퓨틱스, 인크. | 천연 킬러 세포의 활성화를 위한 다중-특이적 결합 단백질 및 암 치료에서의 그의 치료적 용도 |
| EP4273258A3 (en) | 2017-02-20 | 2024-01-17 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| EP3655779A1 (en) * | 2017-07-20 | 2020-05-27 | CytomX Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
| KR102172092B1 (ko) | 2017-09-19 | 2020-10-30 | 주식회사 엘지화학 | 열가소성 수지 조성물, 이의 제조방법 및 성형품 |
| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR20200074966A (ko) * | 2017-10-20 | 2020-06-25 | 난트바이오 인코포레이티드 | 방광암 면역요법을 모니터링하는 방법 |
| MX2020008333A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Terapia de combinacion del cancer que incluye proteinas de union multiespecificas que activan a las celulas asesinas naturales. |
| WO2019157366A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| WO2019160815A1 (en) * | 2018-02-13 | 2019-08-22 | Chimera Bioengineering, Inc. | Coordinating gene expression using rna destabilizing elements |
| MX2020008684A (es) | 2018-02-20 | 2020-12-07 | Dragonfly Therapeutics Inc | Proteinas de union multiespecificas que se unen a cd33, nkg2d y cd16 y metodos de uso. |
| WO2019195408A1 (en) * | 2018-04-03 | 2019-10-10 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting dll3, and use thereof |
| AU2019251473A1 (en) * | 2018-04-10 | 2020-10-22 | Amgen Inc. | Chimeric receptors to DLL3 and methods of use thereof |
| WO2019200022A1 (en) | 2018-04-11 | 2019-10-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| US12037391B2 (en) * | 2018-05-08 | 2024-07-16 | Phanes Therapeutics, Inc. | Anti-DLL3 antibodies and uses thereof |
| CN119192397A (zh) | 2018-05-14 | 2024-12-27 | 哈普恩治疗公司 | 用于条件性激活免疫球蛋白分子的结合部分 |
| US12195533B2 (en) | 2018-07-24 | 2025-01-14 | Inhibrx Biosciences, Inc. | Multispecific polypeptide constructs containing a constrained CD3 binding domain and a receptor binding region and methods of using the same |
| CA3108427A1 (en) | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| MX2021001527A (es) | 2018-08-08 | 2021-06-15 | Dragonfly Therapeutics Inc | Proteínas de unión a nkg2d, cd16 y a un antígeno asociado a tumor. |
| WO2020051562A2 (en) | 2018-09-07 | 2020-03-12 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| WO2020076977A2 (en) * | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| EP3892333A4 (en) * | 2018-12-07 | 2022-11-30 | CRAGE medical Co., Limited | Tumor combined immunotherapy |
| TW202045547A (zh) * | 2019-03-01 | 2020-12-16 | 美商艾洛基因醫療公司 | 靶向ｄｌｌ３的嵌合抗原受體和結合劑 |
| WO2020182517A1 (en) * | 2019-03-08 | 2020-09-17 | Oncolab Diagnostics Gmbh | Cancer diagnosis and prognosis |
| CN113795262A (zh) * | 2019-04-08 | 2021-12-14 | 东莞凡恩世生物医药有限公司 | 人源化抗dll3嵌合抗原受体及其用途 |
| CN117106099A (zh) * | 2019-07-17 | 2023-11-24 | 南京传奇生物科技有限公司 | 一种抗dll3嵌合抗原受体及其用途 |
| JP2022546282A (ja) * | 2019-08-18 | 2022-11-04 | キメラ・バイオエンジニアリング，インコーポレーテッド | Ｇｏｌｄ制御導入遺伝子による併用療法 |
| US11976133B2 (en) * | 2020-01-31 | 2024-05-07 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| US12486331B2 (en) | 2020-01-31 | 2025-12-02 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| CN113444171A (zh) * | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| EP4146271A4 (en) | 2020-05-06 | 2024-09-04 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| WO2022206994A1 (en) * | 2021-04-02 | 2022-10-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells and uses thereof |
| CA3230627A1 (en) * | 2021-09-02 | 2023-03-09 | Memorial Sloan-Kettering Cancer Center | Antigen recognizing receptors targeting dll3 and uses thereof |
| KR20250131823A (ko) | 2023-03-31 | 2025-09-03 | 아벨제타 인크. | Cd20 및 bcma를 표적화하는 이중특이적 키메라 항원 수용체 |
| CN117169518B (zh) * | 2023-11-03 | 2024-01-19 | 赛德特(北京)生物工程有限公司 | T淋巴细胞制剂中的cd3抗体残留物的检测方法和试剂盒 |
| WO2025212519A1 (en) * | 2024-04-01 | 2025-10-09 | Moonlight Bio, Inc. | Dll3 binding proteins and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9127071B2 (en) * | 2010-01-29 | 2015-09-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-DLL3 antibody |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| RS56443B1 (sr) * | 2012-02-24 | 2018-01-31 | Abbvie Stemcentrx Llc | Ddl3 modulatori i postupci primene |
| AU2013278075B2 (en) * | 2012-06-22 | 2018-05-17 | Cytomx Therapeutics, Inc. | Anti-jagged 1/Jagged 2 cross-reactive antibodies, activatable anti-Jagged antibodies and methods of use thereof |
| GB201302447D0 (en) * | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| ME03394B (me) * | 2013-02-22 | 2020-01-20 | Medimmune Ltd | Antidllз-antitelo-pbd konjugati i nihovа upotreba |
| WO2016179319A1 (en) * | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
-
2016
- 2016-02-22 MA MA041613A patent/MA41613A/fr unknown
- 2016-02-23 PE PE2017001455A patent/PE20171383A1/es unknown
- 2016-02-23 HK HK18108019.0A patent/HK1249405A1/zh unknown
- 2016-02-23 CR CR20170436A patent/CR20170436A/es unknown
- 2016-02-23 KR KR1020177026963A patent/KR20170120158A/ko not_active Withdrawn
- 2016-02-23 US US15/553,102 patent/US20180044415A1/en not_active Abandoned
- 2016-02-23 CA CA2977502A patent/CA2977502A1/en not_active Abandoned
- 2016-02-23 EP EP16756219.8A patent/EP3261650A4/en not_active Withdrawn
- 2016-02-23 CN CN201680019227.8A patent/CN107405362A/zh active Pending
- 2016-02-23 MX MX2017010845A patent/MX2017010845A/es unknown
- 2016-02-23 JP JP2017544615A patent/JP2018506981A/ja active Pending
- 2016-02-23 WO PCT/US2016/019192 patent/WO2016138038A1/en not_active Ceased
- 2016-02-23 EA EA201791884A patent/EA201791884A1/ru unknown
- 2016-02-23 TW TW105105289A patent/TW201639887A/zh unknown
- 2016-02-23 SG SG11201706804SA patent/SG11201706804SA/en unknown
- 2016-02-23 BR BR112017017927A patent/BR112017017927A2/pt not_active IP Right Cessation
-
2017
- 2017-08-20 IL IL254068A patent/IL254068A0/en unknown
- 2017-08-22 ZA ZA2017/05720A patent/ZA201705720B/en unknown
- 2017-08-23 DO DO2017000199A patent/DOP2017000199A/es unknown
- 2017-08-23 CL CL2017002150A patent/CL2017002150A1/es unknown
- 2017-08-23 PH PH12017501521A patent/PH12017501521A1/en unknown
- 2017-08-29 CO CONC2017/0008804A patent/CO2017008804A2/es unknown
- 2017-09-22 EC ECIEPI201763327A patent/ECSP17063327A/es unknown
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