JP2018506981A5 - - Google Patents
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- Publication number
- JP2018506981A5 JP2018506981A5 JP2017544615A JP2017544615A JP2018506981A5 JP 2018506981 A5 JP2018506981 A5 JP 2018506981A5 JP 2017544615 A JP2017544615 A JP 2017544615A JP 2017544615 A JP2017544615 A JP 2017544615A JP 2018506981 A5 JP2018506981 A5 JP 2018506981A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- chain variable
- variable region
- cdrs
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562119793P | 2015-02-23 | 2015-02-23 | |
| US62/119,793 | 2015-02-23 | ||
| US201562241662P | 2015-10-14 | 2015-10-14 | |
| US62/241,662 | 2015-10-14 | ||
| US201662296560P | 2016-02-17 | 2016-02-17 | |
| US62/296,560 | 2016-02-17 | ||
| PCT/US2016/019192 WO2016138038A1 (en) | 2015-02-23 | 2016-02-23 | Anti-dll3 chimeric antigen receptors and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018506981A JP2018506981A (ja) | 2018-03-15 |
| JP2018506981A5 true JP2018506981A5 (enExample) | 2019-04-04 |
Family
ID=56789774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544615A Pending JP2018506981A (ja) | 2015-02-23 | 2016-02-23 | 抗ｄｌｌ３キメラ抗原受容体および使用方法 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20180044415A1 (enExample) |
| EP (1) | EP3261650A4 (enExample) |
| JP (1) | JP2018506981A (enExample) |
| KR (1) | KR20170120158A (enExample) |
| CN (1) | CN107405362A (enExample) |
| BR (1) | BR112017017927A2 (enExample) |
| CA (1) | CA2977502A1 (enExample) |
| CL (1) | CL2017002150A1 (enExample) |
| CO (1) | CO2017008804A2 (enExample) |
| CR (1) | CR20170436A (enExample) |
| DO (1) | DOP2017000199A (enExample) |
| EA (1) | EA201791884A1 (enExample) |
| EC (1) | ECSP17063327A (enExample) |
| HK (1) | HK1249405A1 (enExample) |
| IL (1) | IL254068A0 (enExample) |
| MA (1) | MA41613A (enExample) |
| MX (1) | MX2017010845A (enExample) |
| PE (1) | PE20171383A1 (enExample) |
| PH (1) | PH12017501521A1 (enExample) |
| SG (1) | SG11201706804SA (enExample) |
| TW (1) | TW201639887A (enExample) |
| WO (1) | WO2016138038A1 (enExample) |
| ZA (1) | ZA201705720B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230027993A1 (en) | 2014-03-05 | 2023-01-26 | Autolus Limited | Methods |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| ES2889906T3 (es) | 2015-05-21 | 2022-01-14 | Harpoon Therapeutics Inc | Proteínas de unión triespecíficas y usos médicos |
| CA3024723A1 (en) | 2016-05-20 | 2017-11-23 | Robert B. Dubridge | Single domain serum albumin binding protein |
| CN108395482B (zh) * | 2017-02-08 | 2021-02-05 | 西比曼生物科技（香港）有限公司 | 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定 |
| EP4491234A3 (en) | 2017-02-08 | 2025-04-09 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| BR112019017197A2 (pt) | 2017-02-20 | 2020-04-14 | Dragonfly Therapeutics, Inc. | proteínas que se ligam a her2, nkg2d e cd16 |
| EP3655779A1 (en) | 2017-07-20 | 2020-05-27 | CytomX Therapeutics, Inc. | Methods of qualitatively and/or quantitatively analyzing properties of activatable antibodies and uses thereof |
| KR102172092B1 (ko) | 2017-09-19 | 2020-10-30 | 주식회사 엘지화학 | 열가소성 수지 조성물, 이의 제조방법 및 성형품 |
| JP7084990B2 (ja) | 2017-10-13 | 2022-06-15 | ハープーン セラピューティクス，インク． | 三重特異性タンパク質と使用方法 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| EP3698140A4 (en) * | 2017-10-20 | 2021-07-28 | NantBio, Inc. | BLADDER CANCER IMMUNOTHERAPY SURVEILLANCE METHODS |
| AU2019218125B2 (en) | 2018-02-08 | 2025-03-13 | Dragonfly Therapeutics, Inc. | Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells |
| PE20220278A1 (es) | 2018-02-08 | 2022-02-25 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d |
| US11110125B2 (en) * | 2018-02-13 | 2021-09-07 | Chimera Bioengineering, Inc. | Coordinating gene expression using RNA destabilizing elements |
| TW201942134A (zh) | 2018-02-20 | 2019-11-01 | 美商蜻蜓醫療公司 | 結合cd33、nkg2d及cd16之多特異性結合蛋白及使用方法 |
| WO2019195408A1 (en) * | 2018-04-03 | 2019-10-10 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting dll3, and use thereof |
| UA129466C2 (uk) * | 2018-04-10 | 2025-05-07 | Емджен Інк. | Химерні рецептори до dll3 та способи їх застосування |
| WO2019200022A1 (en) | 2018-04-11 | 2019-10-17 | Inhibrx, Inc. | Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses |
| BR112020021280A2 (pt) | 2018-05-08 | 2021-01-26 | Phanes Therapeutics, Inc. | anticorpos anti-dll3 e usos dos mesmos |
| WO2019222283A1 (en) | 2018-05-14 | 2019-11-21 | Harpoon Therapeutics, Inc. | Binding moiety for conditional activation of immunoglobulin molecules |
| TW202035451A (zh) | 2018-07-24 | 2020-10-01 | 美商英伊布里克斯公司 | 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法 |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| US12529041B2 (en) | 2018-09-07 | 2026-01-20 | Beam Therapeutics Inc. | Compositions and methods for delivering a nucleobase editing system |
| US12454694B2 (en) | 2018-09-07 | 2025-10-28 | Beam Therapeutics Inc. | Compositions and methods for improving base editing |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| WO2020076977A2 (en) * | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
| JP2022517301A (ja) * | 2018-12-07 | 2022-03-08 | カファ セラピューティクス リミテッド | 腫瘍併用免疫療法 |
| MX2021010441A (es) * | 2019-03-01 | 2021-09-21 | Allogene Therapeutics Inc | Receptores antigenicos quimericos y agentes de union dirigidos a dll3. |
| CN113874526A (zh) * | 2019-03-08 | 2021-12-31 | 肿瘤实验室诊断有限公司 | 癌症的诊断和预后 |
| BR112021016272A2 (pt) * | 2019-04-08 | 2021-11-09 | Phanes Therapeutics Inc | Receptores de antígeno quimérico anti-dll3 humanizados e usos dos mesmos |
| US12516128B2 (en) | 2019-05-14 | 2026-01-06 | Harpoon Therapeutics, Inc. | EpCAM binding proteins and methods of use |
| CN114072427B (zh) * | 2019-07-17 | 2024-04-26 | 南京传奇生物科技有限公司 | 抗dll3嵌合抗原受体及其用途 |
| JP2022546282A (ja) * | 2019-08-18 | 2022-11-04 | キメラ・バイオエンジニアリング，インコーポレーテッド | Ｇｏｌｄ制御導入遺伝子による併用療法 |
| KR20220148175A (ko) | 2020-01-29 | 2022-11-04 | 인히브릭스, 인크. | Ｃｄ28 단일 도메인 항체 및 이의 다가 및 다중특이적 구조체 |
| US12486331B2 (en) | 2020-01-31 | 2025-12-02 | Gensun Biopharma Inc. | Bispecific T cell engagers |
| AU2021213840A1 (en) * | 2020-01-31 | 2022-09-29 | Suzhou Zelgen Biopharmaceuticals Co. Ltd. | Bispecific T cell engagers |
| CN113402612A (zh) | 2020-03-17 | 2021-09-17 | 西比曼生物科技（香港）有限公司 | 靶向cd19和cd20的联合嵌合抗原受体及其应用 |
| CN113444173A (zh) * | 2020-03-25 | 2021-09-28 | 兴盟生物医药(苏州)有限公司 | 金黄色葡萄球菌α-毒素特异性抗体及其应用 |
| EP4146271A4 (en) | 2020-05-06 | 2024-09-04 | Dragonfly Therapeutics, Inc. | PROTEINS THAT BIND NKG2D, CD16 AND CLEC12A |
| WO2022067089A1 (en) | 2020-09-25 | 2022-03-31 | Beam Therapeutics Inc. | Fratricide resistant modified immune cells and methods of using the same |
| AU2021372988A1 (en) * | 2020-11-06 | 2023-06-22 | Board Of Regents, The University Of Texas System | Methods and systems for classification and treatment of small cell lung cancer |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| WO2022206994A1 (en) * | 2021-04-02 | 2022-10-06 | Nanjing Legend Biotech Co., Ltd. | Engineered immune cells and uses thereof |
| AU2022339815A1 (en) * | 2021-09-02 | 2024-03-14 | Memorial Hospital For Cancer And Allied Diseases | Antigen recognizing receptors targeting dll3 and uses thereof |
| AU2024244733B2 (en) | 2023-03-31 | 2025-12-11 | AbelZeta Inc. | Bispecific chimeric antigen receptors targeting cd20 and bcma |
| CN117169518B (zh) * | 2023-11-03 | 2024-01-19 | 赛德特(北京)生物工程有限公司 | T淋巴细胞制剂中的cd3抗体残留物的检测方法和试剂盒 |
| WO2025212519A1 (en) * | 2024-04-01 | 2025-10-09 | Moonlight Bio, Inc. | Dll3 binding proteins and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2530091T (lt) * | 2010-01-29 | 2018-06-11 | Chugai Seiyaku Kabushiki Kaisha | Anti-dll3 antikūnas |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| EP3093294A1 (en) * | 2012-02-24 | 2016-11-16 | Stemcentrx, Inc. | Dll3 modulators and methods of use |
| WO2013192550A2 (en) * | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| GB201302447D0 (en) * | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
| RU2019109456A (ru) * | 2013-02-22 | 2019-04-10 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые конъюгаты антител и их применения |
| WO2016179319A1 (en) * | 2015-05-04 | 2016-11-10 | Cellerant Therapeutics, Inc. | Chimeric antigen receptors with ctla4 signal transduction domains |
-
2016
- 2016-02-22 MA MA041613A patent/MA41613A/fr unknown
- 2016-02-23 KR KR1020177026963A patent/KR20170120158A/ko not_active Withdrawn
- 2016-02-23 JP JP2017544615A patent/JP2018506981A/ja active Pending
- 2016-02-23 TW TW105105289A patent/TW201639887A/zh unknown
- 2016-02-23 CA CA2977502A patent/CA2977502A1/en not_active Abandoned
- 2016-02-23 US US15/553,102 patent/US20180044415A1/en not_active Abandoned
- 2016-02-23 CR CR20170436A patent/CR20170436A/es unknown
- 2016-02-23 EA EA201791884A patent/EA201791884A1/ru unknown
- 2016-02-23 HK HK18108019.0A patent/HK1249405A1/zh unknown
- 2016-02-23 PE PE2017001455A patent/PE20171383A1/es unknown
- 2016-02-23 CN CN201680019227.8A patent/CN107405362A/zh active Pending
- 2016-02-23 BR BR112017017927A patent/BR112017017927A2/pt not_active IP Right Cessation
- 2016-02-23 EP EP16756219.8A patent/EP3261650A4/en not_active Withdrawn
- 2016-02-23 WO PCT/US2016/019192 patent/WO2016138038A1/en not_active Ceased
- 2016-02-23 SG SG11201706804SA patent/SG11201706804SA/en unknown
- 2016-02-23 MX MX2017010845A patent/MX2017010845A/es unknown
-
2017
- 2017-08-20 IL IL254068A patent/IL254068A0/en unknown
- 2017-08-22 ZA ZA2017/05720A patent/ZA201705720B/en unknown
- 2017-08-23 PH PH12017501521A patent/PH12017501521A1/en unknown
- 2017-08-23 DO DO2017000199A patent/DOP2017000199A/es unknown
- 2017-08-23 CL CL2017002150A patent/CL2017002150A1/es unknown
- 2017-08-29 CO CONC2017/0008804A patent/CO2017008804A2/es unknown
- 2017-09-22 EC ECIEPI201763327A patent/ECSP17063327A/es unknown
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