EA201791884A1 - Химерные антигенные рецепторы против dll3 и способы применения - Google Patents

Химерные антигенные рецепторы против dll3 и способы применения

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Publication number
EA201791884A1
EA201791884A1 EA201791884A EA201791884A EA201791884A1 EA 201791884 A1 EA201791884 A1 EA 201791884A1 EA 201791884 A EA201791884 A EA 201791884A EA 201791884 A EA201791884 A EA 201791884A EA 201791884 A1 EA201791884 A1 EA 201791884A1
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EA
Eurasian Patent Office
Prior art keywords
applications
antigen receptors
receptors against
against dll3
chemeric
Prior art date
Application number
EA201791884A
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English (en)
Russian (ru)
Inventor
Пол Энтони Эскарп
Скотт Дж. Дилла
Дэвид Лью
Роберт А. Сталл
Original Assignee
ЭББВИ СТЕМСЕНТРКС ЭлЭлСи
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Publication date
Application filed by ЭББВИ СТЕМСЕНТРКС ЭлЭлСи filed Critical ЭББВИ СТЕМСЕНТРКС ЭлЭлСи
Publication of EA201791884A1 publication Critical patent/EA201791884A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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EA201791884A 2015-02-23 2016-02-23 Химерные антигенные рецепторы против dll3 и способы применения EA201791884A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562119793P 2015-02-23 2015-02-23
US201562241662P 2015-10-14 2015-10-14
US201662296560P 2016-02-17 2016-02-17
PCT/US2016/019192 WO2016138038A1 (en) 2015-02-23 2016-02-23 Anti-dll3 chimeric antigen receptors and methods of use

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Publication Number Publication Date
EA201791884A1 true EA201791884A1 (ru) 2018-03-30

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EA201791884A EA201791884A1 (ru) 2015-02-23 2016-02-23 Химерные антигенные рецепторы против dll3 и способы применения

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US (1) US20180044415A1 (enExample)
EP (1) EP3261650A4 (enExample)
JP (1) JP2018506981A (enExample)
KR (1) KR20170120158A (enExample)
CN (1) CN107405362A (enExample)
BR (1) BR112017017927A2 (enExample)
CA (1) CA2977502A1 (enExample)
CL (1) CL2017002150A1 (enExample)
CO (1) CO2017008804A2 (enExample)
CR (1) CR20170436A (enExample)
DO (1) DOP2017000199A (enExample)
EA (1) EA201791884A1 (enExample)
EC (1) ECSP17063327A (enExample)
HK (1) HK1249405A1 (enExample)
IL (1) IL254068A0 (enExample)
MA (1) MA41613A (enExample)
MX (1) MX2017010845A (enExample)
PE (1) PE20171383A1 (enExample)
PH (1) PH12017501521A1 (enExample)
SG (1) SG11201706804SA (enExample)
TW (1) TW201639887A (enExample)
WO (1) WO2016138038A1 (enExample)
ZA (1) ZA201705720B (enExample)

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