|
US4343794A
(en)
|
1980-05-06 |
1982-08-10 |
Mt. Sinai |
Method of reducing intraocular pressure with salts of vanadic acid
|
|
US4652586A
(en)
|
1980-11-07 |
1987-03-24 |
The General Hospital Corporation |
Selective beta-2 adrenergic antagonists for the treatment of glaucoma
|
|
US4617299A
(en)
|
1983-12-19 |
1986-10-14 |
Knepper Paul A |
Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
|
|
US5242943A
(en)
|
1984-03-28 |
1993-09-07 |
William J. Louis |
3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
|
|
US4812448A
(en)
|
1984-10-22 |
1989-03-14 |
Knepper Paul A |
Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
|
|
US4757089A
(en)
|
1985-06-14 |
1988-07-12 |
Massachusetts Eye And Ear Infirmary |
Increasing aqueous humor outflow
|
|
US5075323A
(en)
|
1988-08-24 |
1991-12-24 |
Aktiebolaget Hassle |
Compounds including omeprazole in the treatment of glaucoma
|
|
US5260059A
(en)
|
1989-04-14 |
1993-11-09 |
The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University |
Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
|
|
US6372249B1
(en)
|
1991-12-16 |
2002-04-16 |
Baylor College Of Medicine |
Senscent cell-derived inhibitors of DNA synthesis
|
|
US5464866A
(en)
|
1992-08-17 |
1995-11-07 |
Alcon Laboratories, Inc. |
Substituted hydrindanes for the treatment of angiogenesis-dependent diseases
|
|
US5545626A
(en)
|
1994-01-19 |
1996-08-13 |
The Trustees Of Columbia University In The City Of New York |
Method of treating glaucoma with oligonucleotides
|
|
US5585401A
(en)
|
1994-12-09 |
1996-12-17 |
The Reents Of The University Of California |
Method for enhancing outflow of aqueous humor in treatment of glaucoma
|
|
US20020055536A1
(en)
|
1996-09-26 |
2002-05-09 |
Dewitte Robert S. |
System and method for structure-based drug design that includes accurate prediction of binding free energy
|
|
US6489307B1
(en)
|
1998-09-14 |
2002-12-03 |
University Of Florida |
Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
|
|
EP2314700A1
(en)
|
1999-01-28 |
2011-04-27 |
Medical College of Georgia Research Institute, Inc |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA
|
|
US6365576B1
(en)
|
1999-06-24 |
2002-04-02 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Method for inhibiting herpes infection
|
|
CZ302719B6
(cs)
|
2000-12-01 |
2011-09-21 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
|
|
US20020165158A1
(en)
|
2001-03-27 |
2002-11-07 |
King George L. |
Methods of modulating angiogenesis
|
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20040209832A1
(en)
|
2001-11-30 |
2004-10-21 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
US20070049543A1
(en)
|
2001-05-18 |
2007-03-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA
|
|
WO2003059267A2
(en)
|
2001-12-21 |
2003-07-24 |
Rhode Island Hospital |
SELECTIVE 11β-HSD INHIBITORS AND METHODS FOR USE THEREOF
|
|
US7294504B1
(en)
|
2001-12-27 |
2007-11-13 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Methods and compositions for DNA mediated gene silencing
|
|
GB2406568B
(en)
|
2002-02-20 |
2005-09-28 |
Sirna Therapeutics Inc |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US8202845B2
(en)
|
2002-04-18 |
2012-06-19 |
Acuity Pharmaceuticals, Inc. |
Means and methods for the specific modulation of target genes in the CNS and the eye and methods for their identification
|
|
US20040115641A1
(en)
|
2002-12-11 |
2004-06-17 |
Isis Pharmaceuticals Inc. |
Modulation of ROCK 1 expression
|
|
US20040115815A1
(en)
|
2002-07-24 |
2004-06-17 |
Immusol, Inc. |
Single promoter system for making siRNA expression cassettes and expression libraries using a polymerase primer hairpin linker
|
|
WO2004009794A2
(en)
|
2002-07-24 |
2004-01-29 |
Immusol, Inc. |
NOVEL siRNA LIBRARIES AND THEIR PRODUCTION AND USE
|
|
EP1527176B2
(en)
|
2002-08-05 |
2017-03-22 |
Silence Therapeutics GmbH |
Further novel forms of interfering rna molecules
|
|
US20040029275A1
(en)
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
|
WO2004029212A2
(en)
|
2002-09-25 |
2004-04-08 |
University Of Massachusetts |
In vivo gene silencing by chemically modified and stable sirna
|
|
KR20050083855A
(ko)
|
2002-11-01 |
2005-08-26 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
ＨＩＦ-1 알파의 ｓｉＲＮＡ 억제를 위한 조성물 및 방법
|
|
DE10322662A1
(de)
|
2002-11-06 |
2004-10-07 |
Grünenthal GmbH |
Wirksame und stabile DNA-Enzyme
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2213738B1
(en)
|
2002-11-14 |
2012-10-10 |
Dharmacon, Inc. |
siRNA molecules targeting Bcl-2
|
|
US20060257851A1
(en)
|
2002-11-26 |
2006-11-16 |
Itzhak Bentwich |
Bioinformatically detectable group of novel viral regulatory genes and uses thereof
|
|
US20040167090A1
(en)
|
2003-02-21 |
2004-08-26 |
Monahan Sean D. |
Covalent modification of RNA for in vitro and in vivo delivery
|
|
GB0307206D0
(en)
|
2003-03-28 |
2003-04-30 |
Axordia Ltd |
Hyperproliferation
|
|
US20040198640A1
(en)
|
2003-04-02 |
2004-10-07 |
Dharmacon, Inc. |
Stabilized polynucleotides for use in RNA interference
|
|
US7462602B2
(en)
|
2003-05-01 |
2008-12-09 |
University Of Florida Research Foundation, Inc. |
Anti-scarring ribozymes and methods
|
|
US20040224405A1
(en)
|
2003-05-06 |
2004-11-11 |
Dharmacon Inc. |
siRNA induced systemic gene silencing in mammalian systems
|
|
EP1636342A4
(en)
|
2003-06-20 |
2008-10-08 |
Isis Pharmaceuticals Inc |
OLIGOMER COMPOUNDS FOR USE IN THE MODULATION OF GENES
|
|
WO2005034870A2
(en)
|
2003-10-07 |
2005-04-21 |
Renovis, Inc. |
Amide compounds and ion channel ligands and uses thereof
|
|
KR20050039573A
(ko)
|
2003-10-23 |
2005-04-29 |
주식회사 태평양 |
티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물
|
|
WO2005045037A2
(en)
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF 5-ALPHA REDUCTASE AND ANDROGEN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20050208658A1
(en)
|
2003-11-21 |
2005-09-22 |
The University Of Maryland |
RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
|
|
DK1699924T3
(da)
*
|
2003-12-03 |
2019-10-21 |
Ocunexus Therapeutics Inc |
Connexin 43-målrettede hæmmende forbindelser og fremgangsmåder til anvendelse deraf i behandling af hornhindetraume
|
|
US7544803B2
(en)
|
2004-01-23 |
2009-06-09 |
Amgen Inc. |
Vanilloid receptor ligands and their use in treatments
|
|
WO2005076998A2
(en)
|
2004-02-05 |
2005-08-25 |
Intradigm Corporation |
Rnai therapeutics for treatment of eye neovascularization diseases
|
|
GB0403600D0
(en)
|
2004-02-18 |
2004-03-24 |
Trinity College Dublin |
Methods and reagents for treating disease
|
|
AU2005222902B2
(en)
|
2004-03-12 |
2010-06-10 |
Alnylam Pharmaceuticals, Inc. |
iRNA agents targeting VEGF
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
WO2005117938A2
(en)
|
2004-04-13 |
2005-12-15 |
Regents Of The University Of Minnesota |
Methods of treating ocular conditions
|
|
WO2006002361A2
(en)
|
2004-06-24 |
2006-01-05 |
Incyte Corporation |
2-methylpropanamides and their use as pharmaceuticals
|
|
CA2576233C
(en)
|
2004-08-10 |
2016-03-15 |
Alnylam Pharmaceuticals, Inc. |
Conjugate comprising an antagomir and a ligand
|
|
RU2407531C2
(ru)
|
2004-08-23 |
2010-12-27 |
Силентис С.А.У. |
ЛЕЧЕНИЕ ГЛАЗНЫХ БОЛЕЗНЕЙ, ОТЛИЧАЮЩИХСЯ ПОВЫШЕННЫМ ВНУТРИГЛАЗНЫМ ДАВЛЕНИЕМ, С ПОМОЩЬЮ siPHK
|
|
TW200639253A
(en)
|
2005-02-01 |
2006-11-16 |
Alcon Inc |
RNAi-mediated inhibition of ocular targets
|
|
AU2006223131A1
(en)
|
2005-03-11 |
2006-09-21 |
Alcon, Inc. |
RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
|
|
GB0521351D0
(en)
|
2005-10-20 |
2005-11-30 |
Genomica Sau |
Modulation of TRPV expression levels
|
|
JP2010501188A
(ja)
*
|
2006-08-24 |
2010-01-21 |
アルコン リサーチ， リミテッド |
ＩＯＰに関連した病態の処置のためのグレムリンのＲＮＡｉ媒介阻害
|
|
WO2009023025A1
(en)
|
2007-08-13 |
2009-02-19 |
Board Of Trustees Of Southern Illinois University |
Methods for treatment and prevention of ototoxicity by sirna
|
|
TW200927192A
(en)
*
|
2007-11-19 |
2009-07-01 |
Alcon Res Ltd |
Use of TRPV1 receptor antagonists for treating dry eye and ocular pain
|
|
CN201337650Y
(zh)
*
|
2009-01-06 |
2009-11-04 |
河北科技大学 |
一次性药用单剂量液体容器
|
|
EP2390327A1
(en)
*
|
2010-05-27 |
2011-11-30 |
Sylentis S.A. |
siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
|