KR102136539B1 - 눈 증상의 치료 및/또는 예방을 위한 방법 및 조성물에서 sirna 및 이들의 용도 - Google Patents

눈 증상의 치료 및/또는 예방을 위한 방법 및 조성물에서 sirna 및 이들의 용도 Download PDF

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KR102136539B1
KR102136539B1 KR1020157006165A KR20157006165A KR102136539B1 KR 102136539 B1 KR102136539 B1 KR 102136539B1 KR 1020157006165 A KR1020157006165 A KR 1020157006165A KR 20157006165 A KR20157006165 A KR 20157006165A KR 102136539 B1 KR102136539 B1 KR 102136539B1
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sirna
seq
eye
trpv1
misc
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KR20150047513A (ko
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아나 이자벨 지메네즈 앤톤
빅토리아 곤잘레즈 파자르도
베로니카 루즈 팔로마
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실렌티스 에스.에이.유.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020157006165A 2012-09-05 2013-09-04 눈 증상의 치료 및/또는 예방을 위한 방법 및 조성물에서 sirna 및 이들의 용도 Active KR102136539B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1215857.2A GB201215857D0 (en) 2012-09-05 2012-09-05 siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
GB1215857.2 2012-09-05
PCT/EP2013/068245 WO2014037377A1 (en) 2012-09-05 2013-09-04 Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions

Publications (2)

Publication Number Publication Date
KR20150047513A KR20150047513A (ko) 2015-05-04
KR102136539B1 true KR102136539B1 (ko) 2020-07-23

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KR1020157006165A Active KR102136539B1 (ko) 2012-09-05 2013-09-04 눈 증상의 치료 및/또는 예방을 위한 방법 및 조성물에서 sirna 및 이들의 용도

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EP (1) EP2893019B1 (enExample)
JP (2) JP2015529210A (enExample)
KR (1) KR102136539B1 (enExample)
CN (2) CN108354944A (enExample)
AU (1) AU2013311781B2 (enExample)
BR (1) BR112015004469B8 (enExample)
CA (1) CA2883040C (enExample)
CL (1) CL2015000537A1 (enExample)
CY (1) CY1121000T1 (enExample)
DK (1) DK2893019T3 (enExample)
EC (1) ECSP15009391A (enExample)
ES (1) ES2685346T3 (enExample)
GB (1) GB201215857D0 (enExample)
HR (1) HRP20181079T1 (enExample)
HU (1) HUE040096T2 (enExample)
IL (1) IL237389B (enExample)
IN (1) IN2015DN02501A (enExample)
LT (1) LT2893019T (enExample)
MX (1) MX362854B (enExample)
PE (1) PE20150619A1 (enExample)
PL (1) PL2893019T3 (enExample)
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RU (1) RU2663100C2 (enExample)
SG (1) SG11201501386TA (enExample)
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CN108271387B (zh) 2015-08-07 2023-06-27 箭头药业股份有限公司 乙型肝炎病毒感染的RNAi疗法
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
CN113453686B (zh) 2019-02-15 2025-04-15 博士伦爱尔兰有限公司 治疗眼表痛的方法
ES3031607T3 (en) * 2019-10-04 2025-07-09 Senju Pharma Co Pharmaceutical composition containing heterocyclidene acetamide derivative for use in treating dry eye

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CA2883040C (en) 2023-01-17
EP2893019A1 (en) 2015-07-15
GB201215857D0 (en) 2012-10-24
SI2893019T1 (sl) 2018-09-28
RU2663100C2 (ru) 2018-08-01
EP2893019B1 (en) 2018-05-30
LT2893019T (lt) 2018-08-10
ZA201501494B (en) 2016-01-27
MX362854B (es) 2019-02-20
BR112015004469B1 (pt) 2022-11-16
HK1212377A1 (en) 2016-06-10
SG11201501386TA (en) 2015-03-30
PE20150619A1 (es) 2015-05-11
IL237389A0 (en) 2015-04-30
BR112015004469B8 (pt) 2022-12-06
RS57620B1 (sr) 2018-11-30
PL2893019T3 (pl) 2018-12-31
US9808479B2 (en) 2017-11-07
CA2883040A1 (en) 2014-03-13
JP2015529210A (ja) 2015-10-05
WO2014037377A1 (en) 2014-03-13
JP2018138596A (ja) 2018-09-06
HUE040096T2 (hu) 2019-02-28
BR112015004469A2 (pt) 2017-08-08
US20150224131A1 (en) 2015-08-13
CL2015000537A1 (es) 2015-07-10
CN108354944A (zh) 2018-08-03
CY1121000T1 (el) 2019-12-11
DK2893019T3 (en) 2018-09-03
ES2685346T3 (es) 2018-10-08
JP6742362B2 (ja) 2020-08-19
RU2015112121A (ru) 2016-10-27
HRP20181079T1 (hr) 2018-09-07
CN104640988A (zh) 2015-05-20
IN2015DN02501A (enExample) 2015-09-11
IL237389B (en) 2019-01-31
MX2015002802A (es) 2015-05-15
AU2013311781B2 (en) 2018-10-18
AU2013311781A1 (en) 2015-03-12
PT2893019T (pt) 2018-10-19
ECSP15009391A (es) 2015-12-31
KR20150047513A (ko) 2015-05-04

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