HRP20181079T1 - Sirnk i njena primjena u metodama i kompozicijama za liječenje i/ili prevenciju očnih stanja - Google Patents
Sirnk i njena primjena u metodama i kompozicijama za liječenje i/ili prevenciju očnih stanja Download PDFInfo
- Publication number
- HRP20181079T1 HRP20181079T1 HRP20181079TT HRP20181079T HRP20181079T1 HR P20181079 T1 HRP20181079 T1 HR P20181079T1 HR P20181079T T HRP20181079T T HR P20181079TT HR P20181079 T HRP20181079 T HR P20181079T HR P20181079 T1 HRP20181079 T1 HR P20181079T1
- Authority
- HR
- Croatia
- Prior art keywords
- sirna
- use according
- eye
- administered
- treatment
- Prior art date
Links
- 108020004459 Small interfering RNA Proteins 0.000 title claims 18
- 239000000203 mixture Substances 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010015958 Eye pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (8)
1. siRNK usmjerena na SEK ID BR: 1 za primjenu u liječenju suhog oka i/ili boli u oku gdje je siRNK administrirana u dozi od oko 0.3 do oko 0.9 mg po danu.
2. siRNK za primjenu prema patentnom zahtjevu 1 gdje je siRNK administrirana u dozi od oko 0.6 mg ili oko 0.9 mg po oku po danu.
3. siRNK za primjenu prema prethodnom patentnom zahtjevu gdje spomenuta siRNK je administrirana tokom 5-15 dana.
4. siRNK za primjenu prema prethodnom patentnom zahtjevu gdje spomenuta siRNK je administrirana tokom 10 dana.
5. siRNK za primjenu prema prethodnom patentnom zahtjevu gdje spomenuta siRNK je administrirana kronično.
6. siRNK za primjenu prema prethodnom patentnom zahtjevu gdje spomenuta siRNK je spoj definiran kao SEK ID BR: 2.
7. siRNK za primjenu prema prethodnom patentnom zahtjevu gdje spomenuta siRNK je administrirana lokalno na oko.
8. Medicinski komplet za liječenje suhog oka i/ili boli u oku koji sadrži količinu siRNK usmjerenu na SEK ID BR: 1, dozator sa otvorom za doziranje doze od oko 0.3 do oko 0.9 mg siRNK u kapljici unaprijed određene zapremine, i tiskane instrukcije za administriranje siRNK usmjerene na SEK ID BR:1 u skladu sa patentnim zahtjevima 1 do 7 u dozi od oko 0.3 do oko 0.9 mg za dnevnu administraciju.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1215857.2A GB201215857D0 (en) | 2012-09-05 | 2012-09-05 | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| EP13759707.6A EP2893019B1 (en) | 2012-09-05 | 2013-09-04 | Sirna and its use in methods and compositions for the treatment and/or prevention of eye conditions |
| PCT/EP2013/068245 WO2014037377A1 (en) | 2012-09-05 | 2013-09-04 | Sirna and their use in methods and compositions for the treatment and/or prevention of eye conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20181079T1 true HRP20181079T1 (hr) | 2018-09-07 |
Family
ID=47136985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181079TT HRP20181079T1 (hr) | 2012-09-05 | 2018-07-11 | Sirnk i njena primjena u metodama i kompozicijama za liječenje i/ili prevenciju očnih stanja |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9808479B2 (hr) |
| EP (1) | EP2893019B1 (hr) |
| JP (2) | JP2015529210A (hr) |
| KR (1) | KR102136539B1 (hr) |
| CN (2) | CN104640988A (hr) |
| AU (1) | AU2013311781B2 (hr) |
| BR (1) | BR112015004469B8 (hr) |
| CA (1) | CA2883040C (hr) |
| CL (1) | CL2015000537A1 (hr) |
| CY (1) | CY1121000T1 (hr) |
| DK (1) | DK2893019T3 (hr) |
| EC (1) | ECSP15009391A (hr) |
| ES (1) | ES2685346T3 (hr) |
| GB (1) | GB201215857D0 (hr) |
| HK (1) | HK1212377A1 (hr) |
| HR (1) | HRP20181079T1 (hr) |
| HU (1) | HUE040096T2 (hr) |
| IL (1) | IL237389B (hr) |
| IN (1) | IN2015DN02501A (hr) |
| LT (1) | LT2893019T (hr) |
| MX (1) | MX362854B (hr) |
| PE (1) | PE20150619A1 (hr) |
| PL (1) | PL2893019T3 (hr) |
| PT (1) | PT2893019T (hr) |
| RS (1) | RS57620B1 (hr) |
| RU (1) | RU2663100C2 (hr) |
| SG (1) | SG11201501386TA (hr) |
| SI (1) | SI2893019T1 (hr) |
| WO (1) | WO2014037377A1 (hr) |
| ZA (1) | ZA201501494B (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX342731B (es) | 2011-06-30 | 2016-10-11 | Arrowhead Res Corp | Composiciones y metodos para inhibir la expresion genica del virus de hepatitis b. |
| KR20180038465A (ko) | 2015-08-07 | 2018-04-16 | 애로우헤드 파마슈티컬스 인코포레이티드 | Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법 |
| JOP20170161A1 (ar) | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
| JP6994061B2 (ja) | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
| JP2022520832A (ja) | 2019-02-15 | 2022-04-01 | ノバルティス アーゲー | 眼表面疼痛を治療する方法 |
| CA3156484A1 (en) * | 2019-10-04 | 2021-04-08 | Senju Pharmaceutical Co., Ltd. | PHARMACEUTICAL MEDICINAL PRODUCT CONTAINING A HETEROCYCLIDENE ACETAMIDE DERIVATIVE |
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-
2012
- 2012-09-05 GB GBGB1215857.2A patent/GB201215857D0/en not_active Ceased
-
2013
- 2013-09-04 IN IN2501DEN2015 patent/IN2015DN02501A/en unknown
- 2013-09-04 KR KR1020157006165A patent/KR102136539B1/ko active IP Right Grant
- 2013-09-04 PE PE2015000282A patent/PE20150619A1/es not_active Application Discontinuation
- 2013-09-04 PT PT13759707T patent/PT2893019T/pt unknown
- 2013-09-04 RS RS20180877A patent/RS57620B1/sr unknown
- 2013-09-04 CN CN201380046215.0A patent/CN104640988A/zh active Pending
- 2013-09-04 AU AU2013311781A patent/AU2013311781B2/en active Active
- 2013-09-04 BR BR112015004469A patent/BR112015004469B8/pt active IP Right Grant
- 2013-09-04 SI SI201331090T patent/SI2893019T1/sl unknown
- 2013-09-04 MX MX2015002802A patent/MX362854B/es active IP Right Grant
- 2013-09-04 EP EP13759707.6A patent/EP2893019B1/en active Active
- 2013-09-04 HU HUE13759707A patent/HUE040096T2/hu unknown
- 2013-09-04 CN CN201810353730.8A patent/CN108354944A/zh active Pending
- 2013-09-04 JP JP2015530372A patent/JP2015529210A/ja active Pending
- 2013-09-04 PL PL13759707T patent/PL2893019T3/pl unknown
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