JP2018113985A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018113985A5 JP2018113985A5 JP2018073677A JP2018073677A JP2018113985A5 JP 2018113985 A5 JP2018113985 A5 JP 2018113985A5 JP 2018073677 A JP2018073677 A JP 2018073677A JP 2018073677 A JP2018073677 A JP 2018073677A JP 2018113985 A5 JP2018113985 A5 JP 2018113985A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- gene
- editing protein
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261721302P | 2012-11-01 | 2012-11-01 | |
| US61/721,302 | 2012-11-01 | ||
| US201361785404P | 2013-03-14 | 2013-03-14 | |
| US61/785,404 | 2013-03-14 | ||
| US201361842874P | 2013-07-03 | 2013-07-03 | |
| US61/842,874 | 2013-07-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540833A Division JP6510416B2 (ja) | 2012-11-01 | 2013-11-01 | 細胞中でタンパク質を発現するための方法および生成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018113985A JP2018113985A (ja) | 2018-07-26 |
| JP2018113985A5 true JP2018113985A5 (enExample) | 2018-09-06 |
| JP6793146B2 JP6793146B2 (ja) | 2020-12-02 |
Family
ID=50628111
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540833A Active JP6510416B2 (ja) | 2012-11-01 | 2013-11-01 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2018073676A Active JP6890565B2 (ja) | 2012-11-01 | 2018-04-06 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2018073677A Expired - Fee Related JP6793146B2 (ja) | 2012-11-01 | 2018-04-06 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2021027831A Active JP7436406B2 (ja) | 2012-11-01 | 2021-02-24 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2024018042A Active JP7876562B2 (ja) | 2012-11-01 | 2024-02-08 | 細胞中でタンパク質を発現するための方法および生成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015540833A Active JP6510416B2 (ja) | 2012-11-01 | 2013-11-01 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2018073676A Active JP6890565B2 (ja) | 2012-11-01 | 2018-04-06 | 細胞中でタンパク質を発現するための方法および生成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021027831A Active JP7436406B2 (ja) | 2012-11-01 | 2021-02-24 | 細胞中でタンパク質を発現するための方法および生成物 |
| JP2024018042A Active JP7876562B2 (ja) | 2012-11-01 | 2024-02-08 | 細胞中でタンパク質を発現するための方法および生成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (20) | US9447395B2 (enExample) |
| EP (2) | EP3786298A1 (enExample) |
| JP (5) | JP6510416B2 (enExample) |
| KR (4) | KR20230154283A (enExample) |
| CN (1) | CN104769112A (enExample) |
| AU (3) | AU2013337651B2 (enExample) |
| BR (2) | BR122019025681B1 (enExample) |
| CA (2) | CA2890110C (enExample) |
| MX (2) | MX363017B (enExample) |
| RU (2) | RU2711249C2 (enExample) |
| WO (1) | WO2014071219A1 (enExample) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10347710B4 (de) | 2003-10-14 | 2006-03-30 | Johannes-Gutenberg-Universität Mainz | Rekombinante Impfstoffe und deren Verwendung |
| DE102005046490A1 (de) | 2005-09-28 | 2007-03-29 | Johannes-Gutenberg-Universität Mainz | Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| LT2714071T (lt) | 2011-05-24 | 2019-10-10 | Biontech Rna Pharmaceuticals Gmbh | Individualizuotos vakcinos nuo vėžio |
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2841572B1 (en) | 2012-04-27 | 2019-06-19 | Duke University | Genetic correction of mutated genes |
| CA2885216A1 (en) | 2012-09-17 | 2014-03-20 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for treating amyotrophic lateral sclerosis |
| CA2890110C (en) | 2012-11-01 | 2023-05-02 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| PT2922554T (pt) | 2012-11-26 | 2022-06-28 | Modernatx Inc | Arn modificado nas porções terminais |
| AU2013351542B2 (en) | 2012-11-28 | 2018-08-09 | BioNTech SE | Individualized vaccines for cancer |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| WO2014197748A2 (en) | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| RS63942B1 (sr) * | 2013-08-27 | 2023-02-28 | Res Inst Nationwide Childrens Hospital | Proizvodi i postupci za lečenje amiotrofične lateralne skleroze |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| US9725719B2 (en) | 2013-11-05 | 2017-08-08 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for inhibiting NF-κB and SOD-1 to treat amyotrophic lateral sclerosis |
| CN111218447B (zh) | 2013-11-07 | 2024-10-11 | 爱迪塔斯医药有限公司 | 使用统治型gRNA的CRISPR相关方法和组合物 |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015229299A1 (en) * | 2014-03-12 | 2016-09-22 | Precision Biosciences, Inc. | Dystrophin gene exon deletion using engineered nucleases |
| HRP20220070T1 (hr) | 2014-04-23 | 2022-04-01 | Modernatx, Inc. | Cjepiva nukleinske kiseline |
| WO2015168800A1 (en) | 2014-05-09 | 2015-11-12 | UNIVERSITé LAVAL | Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| US10370673B2 (en) | 2014-09-26 | 2019-08-06 | Purecircle Sdn Bhd | Single nucleotide polymorphism (SNP) markers for stevia |
| CN114717264A (zh) | 2014-11-14 | 2022-07-08 | 沃雅戈治疗公司 | 治疗肌萎缩性侧索硬化(als)的组合物和方法 |
| PL3223846T3 (pl) * | 2014-11-26 | 2024-03-11 | Huvepharma, Inc. | Kompozycje adiuwantowe i powiązane sposoby |
| US10195261B2 (en) | 2014-11-26 | 2019-02-05 | VaxLiant, LLC | Adjuvant compositions and related methods |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| US11241505B2 (en) * | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| WO2016154432A1 (en) | 2015-03-24 | 2016-09-29 | VaxLiant, LLC | Adjuvant compositions and related methods |
| CN107787367B (zh) | 2015-04-06 | 2021-10-26 | 里兰斯坦福初级大学理事会 | 用于crispr/cas介导的基因调控的化学修饰的引导rna |
| ES3009026T3 (en) | 2015-07-22 | 2025-03-25 | Univ Duke | High-throughput screening of regulatory element function with epigenome editing technologies |
| WO2017017016A1 (en) * | 2015-07-25 | 2017-02-02 | Frost Habib | A system, device and a method for providing a therapy or a cure for cancer and other pathological states |
| KR20240132120A (ko) | 2015-08-25 | 2024-09-02 | 듀크 유니버시티 | Rna-가이드된 엔도뉴클레아제를 이용하는 게놈 조작에서 특이성을 개선하는 조성물 및 방법 |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| DK3362461T3 (da) | 2015-10-16 | 2022-05-09 | Modernatx Inc | Mrna-cap-analoger med modificeret phosphatbinding |
| US11866754B2 (en) | 2015-10-16 | 2024-01-09 | Modernatx, Inc. | Trinucleotide mRNA cap analogs |
| EP3364949A4 (en) | 2015-10-22 | 2019-07-31 | ModernaTX, Inc. | CANCER VACCINES |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| EP3384038B1 (en) | 2015-11-23 | 2024-07-24 | The Regents of The University of Colorado, A Body Corporate | Methods and compositions for reprogramming cells |
| US12214054B2 (en) | 2015-11-30 | 2025-02-04 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| CN105494263B (zh) * | 2015-12-25 | 2018-11-30 | 哈尔滨医科大学 | 一种产生ho-1/app/psen1三转基因阿尔茨海默病小鼠模型的方法 |
| EP3411078A1 (en) * | 2016-02-02 | 2018-12-12 | Crispr Therapeutics AG | Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome |
| WO2017141109A1 (en) * | 2016-02-18 | 2017-08-24 | Crispr Therapeutics Ag | Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome |
| US11530253B2 (en) | 2016-02-25 | 2022-12-20 | The Children's Medical Center Corporation | Customized class switch of immunoglobulin genes in lymphoma and hybridoma by CRISPR/CAS9 technology |
| US11083799B2 (en) | 2016-03-16 | 2021-08-10 | Crispr Therapeutics Ag | Materials and methods for treatment of hereditary haemochromatosis |
| KR102312903B1 (ko) * | 2016-03-31 | 2021-10-15 | 에트리스 게엠베하 | 신규의 최소 utr 서열 |
| EP3443081A4 (en) | 2016-04-13 | 2019-10-30 | Duke University | CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE |
| WO2017181107A2 (en) * | 2016-04-16 | 2017-10-19 | Ohio State Innovation Foundation | Modified cpf1 mrna, modified guide rna, and uses thereof |
| US10767175B2 (en) | 2016-06-08 | 2020-09-08 | Agilent Technologies, Inc. | High specificity genome editing using chemically modified guide RNAs |
| WO2018013840A1 (en) | 2016-07-13 | 2018-01-18 | Vertex Pharmaceuticals Incorporated | Methods, compositions and kits for increasing genome editing efficiency |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| IL264439B2 (en) * | 2016-08-17 | 2024-08-01 | Factor Bioscience Inc | non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment |
| CN106370765A (zh) * | 2016-08-23 | 2017-02-01 | 国家烟草质量监督检验中心 | 一种基于反相色谱飞行时间质谱的喉癌尿液差异代谢物的测定筛选方法 |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CN106381310B (zh) * | 2016-08-31 | 2020-02-04 | 武汉华美生物工程有限公司 | 一种用t7噬菌体rna聚合酶和t7启动子系统在哺乳动物细胞表达蛋白的方法 |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| CN110214005A (zh) * | 2016-11-11 | 2019-09-06 | DNALite治疗学公司 | 用于基因治疗的结构和方法 |
| KR101908593B1 (ko) * | 2016-12-07 | 2018-10-16 | 연세대학교 산학협력단 | Cftr 유전자 소실 유도 가이드 rna, cftr 변이를 갖는 t84 세포 및 이의 용도 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| WO2018154418A1 (en) * | 2017-02-22 | 2018-08-30 | Crispr Therapeutics Ag | Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders |
| EP3589290A4 (en) * | 2017-02-28 | 2020-12-30 | Arcturus Therapeutics, Inc. | Translatable molecules and synthesis thereof |
| US11168319B1 (en) * | 2017-02-28 | 2021-11-09 | Inari Agriculture Technology, Inc. | Plant cell culture |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| CN107475255B (zh) * | 2017-03-21 | 2021-03-26 | 河北医科大学第二医院 | 一种基因载体介导的基于CRISPR/Cas9基因编辑系统的sgRNA及其用途 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| EP3618839A4 (en) | 2017-05-05 | 2021-06-09 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| WO2018227432A1 (en) * | 2017-06-14 | 2018-12-20 | Wuhan Institute Of Virology, Chinese Academy Of Sciences | Cd2-associated protein (cd2ap) and its interactive proteins |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| TW202413649A (zh) | 2017-10-16 | 2024-04-01 | 美商航海家醫療公司 | 肌萎縮性脊髓側索硬化症(als)之治療 |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| US12509492B2 (en) | 2018-01-19 | 2025-12-30 | Duke University | Genome engineering with CRISPR-Cas systems in eukaryotes |
| US11634722B2 (en) | 2018-01-22 | 2023-04-25 | Inari Agriculture Technology, Inc. | Plant gene editing systems, methods, and compositions |
| CA3095125A1 (en) * | 2018-03-27 | 2019-10-03 | Factor Bioscience Inc. | Nucleic acid-based therapeutics |
| WO2019204643A2 (en) | 2018-04-18 | 2019-10-24 | Altius Institute For Biomedical Sciences | Animal pathogen-derived polypeptides and uses thereof for genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| CN108624592B (zh) * | 2018-05-24 | 2021-08-17 | 苏州大学张家港工业技术研究院 | 针对DJ-1基因编辑的sgRNA筛选及其载体与应用 |
| US20210268086A1 (en) * | 2018-06-27 | 2021-09-02 | Modernatx, Inc. | Personalized cancer vaccine epitope selection |
| WO2020006126A1 (en) | 2018-06-27 | 2020-01-02 | Altius Institute For Biomedical Sciences | Nucleic acid binding domains and methods of use thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| CN108949830B (zh) * | 2018-08-03 | 2021-11-26 | 福州大学 | 一种在鱼类中实现基因组编辑、精确定点基因敲入的方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CN109628404B (zh) * | 2018-12-18 | 2020-04-28 | 浙江大学 | 猪皮下脂肪前体细胞永生化细胞系的构建方法及用途 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| TWI887234B (zh) | 2019-04-14 | 2025-06-21 | 美國公爵大學 | 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除 |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN110200973A (zh) * | 2019-06-19 | 2019-09-06 | 南京市儿童医院 | Dna依赖性蛋白激酶特异性抑制剂在制备防治肾纤维化药物中的用途 |
| CA3145425A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| US11746354B2 (en) | 2019-07-19 | 2023-09-05 | Inari Agriculture Technology, Inc. | Homology dependent repair genome editing |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN110699381A (zh) * | 2019-09-17 | 2020-01-17 | 合肥瑞灵生物科技有限公司 | 地中海贫血病基因治疗载体构建方法及其用途 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US20210290757A1 (en) | 2020-03-23 | 2021-09-23 | Avectas Limited | Engineering of dendritic cells for generation of vaccines against sars-cov-2 |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| CN113151181B (zh) * | 2021-04-14 | 2022-11-29 | 中山大学附属第七医院(深圳) | 一种脂肪干细胞重编程为神经元的方法及负载该神经元的细胞适应性水凝胶修复脊髓损伤 |
| CN113373214B (zh) * | 2021-06-18 | 2024-03-29 | 中国人民解放军军事科学院军事医学研究院 | Cd30在诊断脑神经相关疾病中的用途 |
| WO2023039586A1 (en) | 2021-09-10 | 2023-03-16 | Agilent Technologies, Inc. | Guide rnas with chemical modification for prime editing |
| CN114150017B (zh) * | 2021-11-30 | 2023-05-16 | 长江大学 | 一种调节猪未成熟睾丸支持细胞乳酸分泌水平的方法及应用 |
| CA3260237A1 (en) | 2022-06-24 | 2023-12-28 | Tune Therapeutics, Inc. | Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression |
| WO2024032678A1 (zh) * | 2022-08-11 | 2024-02-15 | 益杰立科(上海)生物科技有限公司 | 一种表观编辑靶点的方法及用途 |
| WO2025084896A1 (ko) * | 2023-10-18 | 2025-04-24 | 연세대학교 산학협력단 | 신경세포 분화 유도용 재조합 벡터 및 이를 포함하는 퇴행성 뇌신경 질환의 예방 또는 치료용 약학적 조성물 |
| CN118667815B (zh) * | 2024-07-16 | 2025-02-14 | 宁夏大学 | 一种靶向prdm1改善牛子宫内膜炎的核苷酸序列及其应用 |
Family Cites Families (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3539465A (en) | 1968-10-08 | 1970-11-10 | Ncr Co | Encapsulation of hydrophilic liquid-in-oil emulsions |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US6743771B2 (en) * | 1995-12-29 | 2004-06-01 | Novactyl, Inc. | Methods and compositions for controlling protein assembly or aggregation |
| JP2001508302A (ja) | 1997-01-10 | 2001-06-26 | ライフ テクノロジーズ，インコーポレイテッド | 胚性幹細胞血清置換 |
| EP1021549A2 (en) | 1997-09-19 | 2000-07-26 | Sequitur, Inc. | SENSE mRNA THERAPY |
| US20110171185A1 (en) | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| EP2292632A3 (en) | 2000-09-26 | 2012-07-25 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| WO2003018767A2 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology, Inc. | Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| WO2003027277A1 (en) | 2001-09-21 | 2003-04-03 | Japan Science And Technology Corporation | Method of screening reporgramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs |
| US20050053588A1 (en) | 2001-10-18 | 2005-03-10 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| GB0202149D0 (en) | 2002-01-30 | 2002-03-20 | Univ Edinburgh | Pluripotency determining factors and uses thereof |
| JP4579911B2 (ja) | 2003-06-03 | 2010-11-10 | アイシス・ファーマシューティカルズ・インコーポレイテッド | スルビビン発現の調節 |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| BRPI0514778B1 (pt) | 2004-09-08 | 2018-07-10 | Wisconsin Alumni Research Foundation | Meio para cultivar células tronco embrionárias |
| BRPI0514641A (pt) | 2004-09-08 | 2008-06-17 | Wisconsin Alumni Res Found | cultivação das células tronco embriÈnica humana |
| CA2595695A1 (en) * | 2005-01-25 | 2006-08-03 | Cell Therapeutics, Inc. | Biologically active protein conjugates comprising (nn[s/t]) peptide repeats and having increased plasma half-life |
| JP5147692B2 (ja) * | 2005-07-13 | 2013-02-20 | ノボ ノルディスク ヘルス ケア アーゲー | 治療用タンパク質生成のための宿主細胞タンパク質ノックアウト細胞 |
| EP1913149A4 (en) * | 2005-07-26 | 2009-08-05 | Sangamo Biosciences Inc | TARGETED INTEGRATION AND EXPRESSION OF EXOGENOUS NUCLEIC ACID SEQUENCES |
| US8323666B2 (en) | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
| US9012219B2 (en) | 2005-08-23 | 2015-04-21 | The Trustees Of The University Of Pennsylvania | RNA preparations comprising purified modified RNA for reprogramming cells |
| PL2578685T3 (pl) | 2005-08-23 | 2020-01-31 | The Trustees Of The University Of Pennsylvania | Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania |
| WO2007026353A2 (en) | 2005-08-29 | 2007-03-08 | Technion Research & Development Foundation Ltd. | Media for culturing stem cells |
| EP2206724A1 (en) | 2005-12-13 | 2010-07-14 | Kyoto University | Nuclear reprogramming factor |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| WO2007079886A1 (de) | 2005-12-22 | 2007-07-19 | Csl Behring Gmbh | Oktanoatreduziertes human albumin |
| DE102006051516A1 (de) * | 2006-10-31 | 2008-05-08 | Curevac Gmbh | (Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins |
| GB0623635D0 (en) | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| WO2008073856A2 (en) | 2006-12-08 | 2008-06-19 | Massachusetts Institute Of Technology | Delivery of nanoparticles and/or agents to cells |
| US10829733B2 (en) | 2007-01-04 | 2020-11-10 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| US20100172882A1 (en) | 2007-01-11 | 2010-07-08 | Glazer Peter M | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| WO2008097926A2 (en) | 2007-02-02 | 2008-08-14 | Yale University | Transient transfection with rna |
| US9249423B2 (en) | 2007-02-02 | 2016-02-02 | Yale University | Method of de-differentiating and re-differentiating somatic cells using RNA |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| MX348010B (es) | 2007-04-07 | 2017-05-23 | Whitehead Inst Biomedical Res | Reprogramacion de celulas somaticas. |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| EP2072618A1 (en) | 2007-12-14 | 2009-06-24 | Johannes Gutenberg-Universität Mainz | Use of RNA for reprogramming somatic cells |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| US20110045001A1 (en) | 2008-03-28 | 2011-02-24 | Biontex Laboratories Gmbh | Transfection results of non-viral gene delivery systems by influencing of the innate immune system |
| CA2720903C (en) * | 2008-04-14 | 2019-01-15 | Sangamo Biosciences, Inc. | Linear donor constructs for targeted integration |
| WO2009127230A1 (en) | 2008-04-16 | 2009-10-22 | Curevac Gmbh | MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION |
| ES2587395T3 (es) | 2008-06-04 | 2016-10-24 | Cellular Dynamics International, Inc. | Procedimientos para la producción de células IPS usando un enfoque no vírico |
| WO2009147400A1 (en) | 2008-06-05 | 2009-12-10 | Iti Scotland Limited | Stem cell culture media and methods |
| WO2010008486A2 (en) | 2008-06-24 | 2010-01-21 | Parkinsons Institute | Pluripotent cell lines and methods of use thereof |
| US20100184033A1 (en) | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| EP2326711A2 (en) | 2008-08-20 | 2011-06-01 | VIRxSYS Corporation | Compositions and methods for generation of pluripotent stem cells |
| EP3450545B1 (en) | 2008-10-24 | 2023-08-23 | Wisconsin Alumni Research Foundation | Pluripotent stem cells obtained by non-viral reprogramming |
| EP2881461A1 (en) * | 2008-11-21 | 2015-06-10 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Reprogramming cells toward a pluripotent state |
| US20110023141A1 (en) * | 2008-12-04 | 2011-01-27 | Sigma-Aldrich Co. | Genomic editing of genes involved with parkinson's disease |
| WO2010079340A2 (en) | 2009-01-08 | 2010-07-15 | Eisai R & D Management Co., Ltd. | Assay |
| US20110239315A1 (en) | 2009-01-12 | 2011-09-29 | Ulla Bonas | Modular dna-binding domains and methods of use |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| EP2213990B1 (fr) | 2009-01-22 | 2016-08-17 | Johnson Controls Technology Company | Procédé de calibration et/ou de correction d'un dispositif d'affichage ayant une aiguille, l'aiguille étant mobile en rotation autour d'un axe de rotation |
| US20100209404A1 (en) | 2009-02-10 | 2010-08-19 | University Of Dayton | Enhanced method for producing stem-like cells from somatic cells |
| US10894944B2 (en) | 2009-04-10 | 2021-01-19 | Monash University | Cell culture media |
| WO2010123501A1 (en) | 2009-04-22 | 2010-10-28 | Massachusetts Institute Of Technology | Innate immune suppression enables repeated delivery of long rna molecules |
| ES2849181T3 (es) | 2009-04-22 | 2021-08-16 | Viacyte Inc | Composiciones celulares derivadas de células reprogramadas desdiferenciadas |
| US10837020B2 (en) | 2009-04-22 | 2020-11-17 | Massachusetts Institute Of Technology | Innate immune suppression enables repeated delivery of long RNA molecules |
| US8496941B2 (en) | 2009-06-03 | 2013-07-30 | National Institute Of Advanced Industrial Science And Technology | Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same |
| EA022786B1 (ru) | 2009-07-31 | 2016-03-31 | Этрис Гмбх | Рнк с комбинацией из немодифицированных и модифицированных нуклеотидов для экспрессии белков |
| WO2011036640A2 (en) * | 2009-09-24 | 2011-03-31 | Cellectis | Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations |
| AU2010312291A1 (en) * | 2009-10-29 | 2012-06-21 | Mcmaster University | Generating induced pluripotent stem cells and progenitor cells from fibroblasts |
| KR101775926B1 (ko) | 2009-11-04 | 2017-09-07 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 화학 물질을 이용한 에피솜 재프로그래밍 |
| EP2499239A1 (en) | 2009-11-11 | 2012-09-19 | Sanford-Burnham Medical Research Institute | METHOD FOR GENERATION AND REGULATION OF iPS CELLS AND COMPOSITIONS THEREOF |
| US20130189741A1 (en) | 2009-12-07 | 2013-07-25 | Cellscript, Inc. | Compositions and methods for reprogramming mammalian cells |
| ES2769129T3 (es) | 2009-12-07 | 2020-06-24 | Univ Pennsylvania | Preparaciones de ARN que comprenden ARN modificado purificado para reprogramar células |
| PT2816112T (pt) * | 2009-12-10 | 2018-11-20 | Univ Iowa State Res Found Inc | Modificação do adn modificada pelo efector tal |
| US8557972B2 (en) | 2009-12-21 | 2013-10-15 | University Of Washington Through Its Center For Commercialization | Compositions and methods for transfection of RNA and controlled stabilization of transfected RNA |
| WO2011094738A1 (en) * | 2010-02-01 | 2011-08-04 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced efficiency of induced pluripotent stem cell generation |
| WO2011110886A1 (en) | 2010-03-09 | 2011-09-15 | Biolamina Ab | Composition and method for enabling proliferation of pluripotent human stem cells |
| WO2011130624A2 (en) | 2010-04-16 | 2011-10-20 | Immune Disease Institute, Inc. | Sustained polypeptide expression from synthetic, modified rnas and uses thereof |
| US9725695B2 (en) | 2010-05-05 | 2017-08-08 | The Regents Of The University Of California | Stem cell defined media for xeno-free and feeder free conditions and uses thereof |
| EP2569424A1 (en) * | 2010-05-12 | 2013-03-20 | Cellectis | Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof |
| US8048675B1 (en) | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
| AU2011256838B2 (en) * | 2010-05-17 | 2014-10-09 | Sangamo Therapeutics, Inc. | Novel DNA-binding proteins and uses thereof |
| EP2392208B1 (en) * | 2010-06-07 | 2016-05-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use |
| WO2011159369A1 (en) * | 2010-06-14 | 2011-12-22 | Iowa State University Research Foundation, Inc. | Nuclease activity of tal effector and foki fusion protein |
| CA2802249A1 (en) * | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| CN108531444A (zh) | 2010-08-05 | 2018-09-14 | 威斯康星校友研究基金会 | 用于人多能细胞培养的简化基础培养基 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| US20140127814A1 (en) | 2010-08-10 | 2014-05-08 | Srinivasan Chandrasegaran | Generation and use of pluripotent stem cells |
| GB201014169D0 (en) * | 2010-08-25 | 2010-10-06 | Cambridge Entpr Ltd | In vitro hepatic differentiation |
| US9447408B2 (en) | 2010-09-14 | 2016-09-20 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| EP3511420B1 (en) * | 2010-09-27 | 2021-04-07 | Sangamo Therapeutics, Inc. | Compositions for inhibiting viral entry into cells |
| EP2857499A1 (en) | 2010-10-01 | 2015-04-08 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625278A1 (en) * | 2010-10-08 | 2013-08-14 | Regents of the University of Minnesota | A method to increase gene targeting frequency |
| WO2012060473A1 (en) | 2010-11-04 | 2012-05-10 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| WO2012094132A1 (en) * | 2011-01-05 | 2012-07-12 | Sangamo Biosciences, Inc. | Methods and compositions for gene correction |
| US9499592B2 (en) * | 2011-01-26 | 2016-11-22 | President And Fellows Of Harvard College | Transcription activator-like effectors |
| KR20120096395A (ko) * | 2011-02-22 | 2012-08-30 | 주식회사 툴젠 | 뉴클레아제에 의해 유전자 변형된 세포를 농축시키는 방법 |
| MX363013B (es) * | 2011-02-25 | 2019-03-04 | Recombinetics Inc | Animales genéticamente modificados y métodos para su obtención. |
| AU2012225497A1 (en) * | 2011-03-07 | 2013-10-24 | Massachusetts Institute Of Technology | Methods for transfecting cells with nucleic acids |
| CA2831613A1 (en) * | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US10086043B2 (en) | 2011-04-03 | 2018-10-02 | The General Hospital Corporation | Efficient protein expression in vivo using modified RNA (MOD-RNA) |
| US20140115726A1 (en) * | 2011-04-05 | 2014-04-24 | Cellectis | New tale-protein scaffolds and uses thereof |
| US9862926B2 (en) | 2011-06-27 | 2018-01-09 | Cellscript, Llc. | Inhibition of innate immune response |
| WO2013009825A1 (en) | 2011-07-11 | 2013-01-17 | Cellular Dynamics International, Inc. | Methods for cell reprogramming and genome engineering |
| EP2758529B1 (en) * | 2011-09-21 | 2019-03-20 | Sangamo Therapeutics, Inc. | Methods and compositions for regulation of transgene expression |
| PT3682905T (pt) | 2011-10-03 | 2022-04-07 | Modernatx Inc | Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| EP3260140B1 (en) * | 2011-12-05 | 2021-02-03 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| ES2923757T3 (es) | 2011-12-16 | 2022-09-30 | Modernatx Inc | Composiciones de ARNm modificado |
| AU2012358384A1 (en) | 2011-12-21 | 2014-07-31 | Moderna Therapeutics, Inc. | Methods of increasing the viability or longevity of an organ or organ explant |
| DK3421601T3 (da) | 2011-12-30 | 2020-02-24 | Cellscript Llc | Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt |
| WO2013151664A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins |
| WO2013152220A2 (en) * | 2012-04-04 | 2013-10-10 | Life Technologies Corporation | Tal-effector assembly platform, customized services, kits and assays |
| AU2013246419A1 (en) | 2012-04-10 | 2014-10-30 | City Of Hope | RNA aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells |
| AU2013251649B2 (en) | 2012-04-24 | 2019-04-04 | Vcell Therapeutics, Inc. | Generating pluripotent cells de novo |
| US9738879B2 (en) * | 2012-04-27 | 2017-08-22 | Duke University | Genetic correction of mutated genes |
| US10119150B2 (en) | 2012-05-13 | 2018-11-06 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| US10155929B2 (en) | 2012-05-13 | 2018-12-18 | Allele Biotechnology & Pharmaceuticals, Inc. | Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA |
| CN104520424B (zh) | 2012-05-13 | 2019-06-28 | 美国绿阳生物技术及医药公司 | 使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞 |
| HUE051612T2 (hu) * | 2012-07-11 | 2021-03-01 | Sangamo Therapeutics Inc | Eljárások és készítmények lizoszomális tárolási betegségek kezelésére |
| EP2684892A1 (en) * | 2012-07-13 | 2014-01-15 | Association Française contre les Myopathies | Compositions and methods for duchenne muscular dystrophy gene therapy |
| WO2014059173A2 (en) * | 2012-10-10 | 2014-04-17 | Sangamo Biosciences, Inc. | T cell modifying compounds and uses thereof |
| CA2890110C (en) * | 2012-11-01 | 2023-05-02 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| US20140140969A1 (en) * | 2012-11-20 | 2014-05-22 | Sangamo Biosciences, Inc. | Methods and compositions for muscular dystrophies |
| CA2892448A1 (en) * | 2012-12-05 | 2014-06-12 | Sangamo Biosciences, Inc. | Methods and compositions for regulation of metabolic disorders |
| US10525075B2 (en) | 2013-02-22 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds, compositions, methods, and kits relating to telomere extension |
| WO2014197748A2 (en) * | 2013-06-05 | 2014-12-11 | Duke University | Rna-guided gene editing and gene regulation |
| CN104878020B (zh) | 2015-04-29 | 2017-09-15 | 华中农业大学 | 一种控制水稻叶片直立性发育的基因及其应用 |
| IL264439B2 (en) * | 2016-08-17 | 2024-08-01 | Factor Bioscience Inc | non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment |
-
2013
- 2013-11-01 CA CA2890110A patent/CA2890110C/en active Active
- 2013-11-01 KR KR1020237036946A patent/KR20230154283A/ko not_active Ceased
- 2013-11-01 RU RU2015120524A patent/RU2711249C2/ru active
- 2013-11-01 CA CA3150985A patent/CA3150985A1/en active Pending
- 2013-11-01 AU AU2013337651A patent/AU2013337651B2/en not_active Ceased
- 2013-11-01 KR KR1020157013918A patent/KR102121086B1/ko active Active
- 2013-11-01 JP JP2015540833A patent/JP6510416B2/ja active Active
- 2013-11-01 RU RU2019143431A patent/RU2019143431A/ru unknown
- 2013-11-01 CN CN201380056620.0A patent/CN104769112A/zh active Pending
- 2013-11-01 EP EP20184168.1A patent/EP3786298A1/en not_active Withdrawn
- 2013-11-01 KR KR1020217033133A patent/KR102596302B1/ko active Active
- 2013-11-01 KR KR1020207015879A patent/KR102315098B1/ko active Active
- 2013-11-01 EP EP13850281.0A patent/EP2914728B1/en active Active
- 2013-11-01 WO PCT/US2013/068118 patent/WO2014071219A1/en not_active Ceased
- 2013-11-01 BR BR122019025681-0A patent/BR122019025681B1/pt active IP Right Grant
- 2013-11-01 MX MX2015005346A patent/MX363017B/es unknown
- 2013-11-01 BR BR122019025678-0A patent/BR122019025678B1/pt active IP Right Grant
-
2015
- 2015-04-27 MX MX2019002498A patent/MX2019002498A/es unknown
- 2015-04-30 US US14/701,199 patent/US9447395B2/en active Active
- 2015-06-10 US US14/735,603 patent/US9376669B2/en active Active
-
2016
- 2016-05-17 US US15/156,806 patent/US9464285B2/en active Active
- 2016-05-17 US US15/156,829 patent/US9487768B2/en active Active
- 2016-09-20 US US15/270,469 patent/US9657282B2/en active Active
-
2017
- 2017-04-13 US US15/487,088 patent/US9758797B2/en active Active
- 2017-08-07 US US15/670,639 patent/US10415060B2/en active Active
-
2018
- 2018-04-06 JP JP2018073676A patent/JP6890565B2/ja active Active
- 2018-04-06 JP JP2018073677A patent/JP6793146B2/ja not_active Expired - Fee Related
- 2018-11-16 AU AU2018264115A patent/AU2018264115B2/en not_active Ceased
-
2019
- 2019-07-26 US US16/523,558 patent/US10590437B2/en active Active
- 2019-10-16 US US16/654,532 patent/US11339409B2/en not_active Expired - Fee Related
- 2019-10-16 US US16/654,536 patent/US10752917B2/en active Active
- 2019-10-16 US US16/654,726 patent/US11339410B2/en active Active
- 2019-10-17 US US16/655,766 patent/US10767195B2/en active Active
- 2019-10-17 US US16/655,760 patent/US11332758B2/en active Active
- 2019-10-17 US US16/655,744 patent/US10724053B2/en active Active
- 2019-10-18 US US16/657,325 patent/US10752919B2/en active Active
- 2019-10-18 US US16/657,318 patent/US11332759B2/en active Active
- 2019-10-18 US US16/657,321 patent/US10752918B2/en active Active
-
2020
- 2020-06-25 US US16/912,321 patent/US12006508B2/en active Active
-
2021
- 2021-02-24 JP JP2021027831A patent/JP7436406B2/ja active Active
- 2021-10-15 AU AU2021250972A patent/AU2021250972A1/en not_active Abandoned
-
2022
- 2022-04-12 US US17/718,668 patent/US20220243228A1/en not_active Abandoned
-
2024
- 2024-02-08 JP JP2024018042A patent/JP7876562B2/ja active Active
-
2025
- 2025-08-22 US US19/307,835 patent/US20260078413A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kaji et al. | Virus-free induction of pluripotency and subsequent excision of reprogramming factors | |
| Staahl et al. | Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes | |
| EP3294873B2 (en) | Targeting bcl11a enhancer functional regions for fetal hemoglobin reinduction | |
| JP5558097B2 (ja) | 効率的な核初期化方法 | |
| JP2017035113A5 (enExample) | ||
| RU2017118312A (ru) | Способы и препараты для трансфекции клеток | |
| Wang | Application of modified mRNA in somatic reprogramming to pluripotency and directed conversion of cell fate | |
| US20090191171A1 (en) | Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination | |
| Sułkowski et al. | Introduction of exogenous HSV-TK suicide gene increases safety of keratinocyte-derived induced pluripotent stem cells by providing genetic “emergency exit” switch | |
| JP2019058176A (ja) | 新規方法 | |
| Nguyen et al. | Patient-specific iPSC-derived RPE for modeling of retinal diseases | |
| Lai et al. | Advancements in reprogramming strategies for the generation of induced pluripotent stem cells | |
| CN103739718B (zh) | 用于诱导多能干细胞的融合蛋白及其使用方法 | |
| Pietronave et al. | Advances and applications of induced pluripotent stem cells | |
| CN109486814A (zh) | 一种用于修复HBB1基因点突变的gRNA、基因编辑系统、表达载体和基因编辑试剂盒 | |
| Lipus et al. | Targeted integration of inducible caspase-9 in human iPSCs allows efficient in vitro clearance of iPSCs and iPSC-macrophages | |
| WO2009092042A1 (en) | Reprogramming of differentiated progenitor or somatic cells using homologous recombination | |
| JP7606176B2 (ja) | ゲノム編集効率を向上させる融合タンパク質及びその使用 | |
| Inagaki | Cell reprogramming and differentiation utilizing messenger RNA for regenerative medicine | |
| US20190136200A1 (en) | Cellular Reprogramming Utilizing mRNA | |
| EP3966327A1 (en) | Crispr/cas all-in-two vector systems for treatment of dmd | |
| Zahoor et al. | Induced pluripotent stem cells in birds: opportunities and challenges for science and agriculture | |
| Gjaltema et al. | KRAB-induced heterochromatin effectively silences PLOD2 gene expression in somatic cells and is resilient to TGFβ1 activation | |
| Tian et al. | Rationale and methodology of reprogramming for generation of induced pluripotent stem cells and induced neural progenitor cells | |
| CN116004520A (zh) | 带双安全开关的诱导多功能干细胞及其制备方法 |