JP2018021051A5 - - Google Patents
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- JP2018021051A5 JP2018021051A5 JP2017160336A JP2017160336A JP2018021051A5 JP 2018021051 A5 JP2018021051 A5 JP 2018021051A5 JP 2017160336 A JP2017160336 A JP 2017160336A JP 2017160336 A JP2017160336 A JP 2017160336A JP 2018021051 A5 JP2018021051 A5 JP 2018021051A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003839 salts Chemical class 0.000 claims 40
- 239000011780 sodium chloride Substances 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 36
- 125000000217 alkyl group Chemical group 0.000 claims 17
- 125000000753 cycloalkyl group Chemical group 0.000 claims 11
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 241000711904 Pneumoviridae Species 0.000 claims 4
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 4
- 208000001756 Virus Disease Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 3
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 241000711920 Human orthopneumovirus Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 125000006242 amine protecting group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N oxygen atom Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 0 *[C@]([C@@]1F)[C@](CO)(O)O[C@]1c1ccc2[n]1*CCC(*)/N=C2/N* Chemical compound *[C@]([C@@]1F)[C@](CO)(O)O[C@]1c1ccc2[n]1*CCC(*)/N=C2/N* 0.000 description 4
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902544P | 2013-11-11 | 2013-11-11 | |
| US61/902,544 | 2013-11-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528882A Division JP6234571B2 (ja) | 2013-11-11 | 2014-11-06 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000710A Division JP2018070658A (ja) | 2013-11-11 | 2018-01-05 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018021051A JP2018021051A (ja) | 2018-02-08 |
| JP2018021051A5 true JP2018021051A5 (US07794700-20100914-C00125.png) | 2018-03-22 |
| JP6393380B2 JP6393380B2 (ja) | 2018-09-19 |
Family
ID=52003049
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528882A Active JP6234571B2 (ja) | 2013-11-11 | 2014-11-06 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2017160336A Active JP6393380B2 (ja) | 2013-11-11 | 2017-08-23 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2018000710A Withdrawn JP2018070658A (ja) | 2013-11-11 | 2018-01-05 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2019222179A Active JP7054394B2 (ja) | 2013-11-11 | 2019-12-09 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2020193294A Active JP7247155B2 (ja) | 2013-11-11 | 2020-11-20 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2022063956A Withdrawn JP2022088661A (ja) | 2013-11-11 | 2022-04-07 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2024006714A Pending JP2024041986A (ja) | 2013-11-11 | 2024-01-19 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528882A Active JP6234571B2 (ja) | 2013-11-11 | 2014-11-06 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018000710A Withdrawn JP2018070658A (ja) | 2013-11-11 | 2018-01-05 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2019222179A Active JP7054394B2 (ja) | 2013-11-11 | 2019-12-09 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2020193294A Active JP7247155B2 (ja) | 2013-11-11 | 2020-11-20 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2022063956A Withdrawn JP2022088661A (ja) | 2013-11-11 | 2022-04-07 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2024006714A Pending JP2024041986A (ja) | 2013-11-11 | 2024-01-19 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
Country Status (36)
Families Citing this family (47)
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| EA201791916A1 (ru) * | 2012-03-13 | 2018-07-31 | Джилид Сайэнс, Инк. | 2'-замещенные карбануклеозидные аналоги для противовирусного лечения |
| CN104936970A (zh) | 2012-10-08 | 2015-09-23 | 埃迪尼克斯医药公司 | 用于hcv感染的2′-氯核苷类似物 |
| AR094537A1 (es) | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
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