JP2017538435A5 - - Google Patents

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JP2017538435A5
JP2017538435A5 JP2017533539A JP2017533539A JP2017538435A5 JP 2017538435 A5 JP2017538435 A5 JP 2017538435A5 JP 2017533539 A JP2017533539 A JP 2017533539A JP 2017533539 A JP2017533539 A JP 2017533539A JP 2017538435 A5 JP2017538435 A5 JP 2017538435A5
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Japan
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medium
poloxamer
concentration
liquid medium
hole
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JP2017533539A
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Japanese (ja)
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JP6843750B2 (ja
JP2017538435A (ja
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Priority claimed from PCT/US2015/067040 external-priority patent/WO2016106192A2/en
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JP2017533539A 2014-12-22 2015-12-21 哺乳類細胞の培養方法 Active JP6843750B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095734P 2014-12-22 2014-12-22
US62/095,734 2014-12-22
PCT/US2015/067040 WO2016106192A2 (en) 2014-12-22 2015-12-21 Methods of culturing a mammalian cell

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020177700A Division JP7075463B2 (ja) 2014-12-22 2020-10-23 哺乳類細胞の培養方法

Publications (3)

Publication Number Publication Date
JP2017538435A JP2017538435A (ja) 2017-12-28
JP2017538435A5 true JP2017538435A5 (enExample) 2019-01-31
JP6843750B2 JP6843750B2 (ja) 2021-03-17

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ID=55527619

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Application Number Title Priority Date Filing Date
JP2017533539A Active JP6843750B2 (ja) 2014-12-22 2015-12-21 哺乳類細胞の培養方法
JP2020177700A Active JP7075463B2 (ja) 2014-12-22 2020-10-23 哺乳類細胞の培養方法
JP2022079207A Pending JP2022107000A (ja) 2014-12-22 2022-05-13 哺乳類細胞の培養方法
JP2024014536A Pending JP2024050754A (ja) 2014-12-22 2024-02-02 哺乳類細胞の培養方法

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Application Number Title Priority Date Filing Date
JP2020177700A Active JP7075463B2 (ja) 2014-12-22 2020-10-23 哺乳類細胞の培養方法
JP2022079207A Pending JP2022107000A (ja) 2014-12-22 2022-05-13 哺乳類細胞の培養方法
JP2024014536A Pending JP2024050754A (ja) 2014-12-22 2024-02-02 哺乳類細胞の培養方法

Country Status (14)

Country Link
US (2) US11306341B2 (enExample)
EP (1) EP3237604B1 (enExample)
JP (4) JP6843750B2 (enExample)
KR (3) KR102568951B1 (enExample)
CN (1) CN107567495A (enExample)
AU (3) AU2015369809B2 (enExample)
BR (1) BR112017013423B1 (enExample)
CA (2) CA3225136A1 (enExample)
IL (2) IL308064A (enExample)
MX (2) MX383857B (enExample)
RU (1) RU2712746C2 (enExample)
SG (2) SG11201705103WA (enExample)
TW (3) TWI843012B (enExample)
WO (1) WO2016106192A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2717927T3 (es) 2013-02-22 2019-06-26 Genzyme Corp Procedimientos de cultivo por perfusión de microportadores y usos de los mismos
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
CA3225136A1 (en) 2014-12-22 2016-06-30 Genzyme Corporation Methods of culturing a mammalian cell
CA3094076C (en) 2018-03-16 2025-11-25 Genzyme Corporation Methods for improving cell viability in a production bioreactor
EP4196769A4 (en) 2020-08-12 2024-08-07 Allen Institute Systems, devices, and methods for quality control of cell production using predictive tagging
CN112795531B (zh) * 2021-04-11 2021-08-06 依科赛生物科技(太仓)有限公司 一种cho细胞无血清无蛋白培养基及其用途
MX2023012193A (es) * 2021-04-14 2023-10-25 Genzyme Corp Metodos de cultivo de perfusion de una celula de mamifero.
JPWO2023054556A1 (enExample) * 2021-09-30 2023-04-06
CN119968454A (zh) 2022-09-28 2025-05-09 建新公司 用于生产生物产品的系统和装置及其使用方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5658782A (en) 1993-10-20 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A Non-Profit Organization Amino acid transporters and uses
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5721121A (en) 1995-06-06 1998-02-24 Genentech, Inc. Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein
US6458574B1 (en) * 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
JP4176472B2 (ja) 2000-12-20 2008-11-05 バイエル・フアーマシユーチカルズ・コーポレーシヨン 哺乳動物細胞の種連続増殖(seed−trainexpansion)のための装置及び方法
WO2002101019A2 (en) 2001-06-13 2002-12-19 Genentech, Inc. Methods of culturing animal cells and polypeptide production in animal cells
WO2003039459A2 (en) 2001-11-05 2003-05-15 Genvec, Inc. Viral vector production methods and compositions
US6953692B2 (en) 2001-12-18 2005-10-11 Bayer Pharmaceuticals Corporation Device and method for seed-train expansion of mammalian cells
US7067279B1 (en) * 2002-08-23 2006-06-27 Immunex Corporation Cell culture performance with betaine
US6974681B1 (en) 2002-08-23 2005-12-13 Immunex Corporation Cell culture performance with vanadate
US20050186669A1 (en) 2004-02-20 2005-08-25 Cesco Bioengineering Co., Ltd. Apparatus and method for preparing and culturing cells
EP1720972B1 (en) 2004-03-05 2014-01-08 DSM IP Assets B.V. Process for cell culturing by continuous perfusion and alternating tangential flow
JP4914835B2 (ja) 2004-09-16 2012-04-11 ベクトン・ディキンソン・アンド・カンパニー 細胞培養用の潅流バイオリアクタ
WO2006138143A1 (en) 2005-06-15 2006-12-28 Amprotein Corporation Suspension culture vessels
ES2662589T3 (es) 2005-06-15 2018-04-09 Zhejiang Jinyishengshi Bioengineering Co., Ltd. Recipientes para cultivo en suspensión
US20080206819A1 (en) * 2006-08-21 2008-08-28 Mary Tsao Intensified Perfusion Production Method
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
MX353340B (es) 2006-09-13 2018-01-09 Abbvie Inc Mejoras de cultivos celulares.
WO2008106515A1 (en) 2007-02-27 2008-09-04 The Board Of Trustees Of The University Of Illinois Insert device for multiwell plate
WO2009034186A2 (en) 2007-09-13 2009-03-19 Helmholtz-Zentrum für Infektionsforschung GmbH Process for cell cultivation
EP2205244B1 (en) 2007-11-08 2013-08-21 Ambit Biosciences Corporation Methods of administering n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy-)imidazo-[2,1-b]-[1,3]-benzothiazol-2-yl]-phenyl}urea to treat proliferative disease
MX2010007344A (es) 2007-12-31 2010-11-09 Baxter Int Furina recombinante substancialmente libre de proteina animal y metodos para la produccion de la misma.
US20090233334A1 (en) * 2008-03-11 2009-09-17 Excellgene Sa Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale
DE102008019691A1 (de) 2008-04-15 2009-10-29 Technische Universität Ilmenau Teilaktives mikrofluidisches System für die 3D-Zellkultivierung sowie Verfahren zu dessen Perfusion
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
KR101131867B1 (ko) 2009-08-13 2012-04-03 (주)히스토스템 폴리감마글루탐산을 포함하는 배양 세포 손상 방지를 위한 배지 첨가용 조성물
DK2501822T3 (da) * 2009-11-17 2017-11-27 Squibb & Sons Llc Fremgangsmåder til forbedret proteinproduktion
AU2012252305B2 (en) 2011-05-12 2017-02-02 Probiogen Ag Enhancement of protein production yield mediated by a fast shuttling cdc42 gtpase
US20150004686A1 (en) 2012-02-02 2015-01-01 Corning Incorporated Automatic continuous perfusion cell culture microplate consumables
SG10201607963SA (en) 2012-04-01 2016-11-29 Emd Millipore Corp Cell culture and gradient migration assay method and devices
AU2013334602B2 (en) 2012-10-23 2018-05-31 Genzyme Corporation Perfusion culturing methods and uses thereof
WO2014130872A2 (en) 2013-02-22 2014-08-28 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
ES2717927T3 (es) 2013-02-22 2019-06-26 Genzyme Corp Procedimientos de cultivo por perfusión de microportadores y usos de los mismos
CN118388581A (zh) 2013-03-08 2024-07-26 建新公司 治疗性蛋白药物物质的整合连续制造
US20140271633A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Mammalian cell culture performance through surfactant supplementation of feed media
JP6742902B2 (ja) 2013-03-15 2020-08-19 ジェンザイム・コーポレーション 高密度細胞バンキングの方法
US20160131634A1 (en) * 2013-05-29 2016-05-12 Biogen Ma Inc. Methods of evaluating cell culture additives
KR20230142653A (ko) 2013-09-16 2023-10-11 젠자임 코포레이션 세포 배양물을 가공하는 방법 및 시스템
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
SG10202113019XA (en) 2014-06-04 2021-12-30 Amgen Inc Methods for harvesting mammalian cell cultures
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
CA3225136A1 (en) 2014-12-22 2016-06-30 Genzyme Corporation Methods of culturing a mammalian cell
SG11201909087PA (en) 2017-03-31 2019-10-30 Boehringer Ingelheim Int Perfusion medium
KR20220066970A (ko) 2019-09-27 2022-05-24 베링거 인겔하임 인터내셔날 게엠베하 농축 관류식 배지
MX2023012193A (es) 2021-04-14 2023-10-25 Genzyme Corp Metodos de cultivo de perfusion de una celula de mamifero.

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