JP2017537883A5 - - Google Patents

Download PDF

Info

Publication number
JP2017537883A5
JP2017537883A5 JP2017520520A JP2017520520A JP2017537883A5 JP 2017537883 A5 JP2017537883 A5 JP 2017537883A5 JP 2017520520 A JP2017520520 A JP 2017520520A JP 2017520520 A JP2017520520 A JP 2017520520A JP 2017537883 A5 JP2017537883 A5 JP 2017537883A5
Authority
JP
Japan
Prior art keywords
pharmaceutical composition
composition according
sustained release
weight
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017520520A
Other languages
English (en)
Japanese (ja)
Other versions
JP6655075B2 (ja
JP2017537883A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/060940 external-priority patent/WO2016081383A1/en
Publication of JP2017537883A publication Critical patent/JP2017537883A/ja
Publication of JP2017537883A5 publication Critical patent/JP2017537883A5/ja
Application granted granted Critical
Publication of JP6655075B2 publication Critical patent/JP6655075B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017520520A 2014-11-17 2015-11-16 オナプリストン持続放出組成物および方法 Expired - Fee Related JP6655075B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080868P 2014-11-17 2014-11-17
US62/080,868 2014-11-17
PCT/US2015/060940 WO2016081383A1 (en) 2014-11-17 2015-11-16 Onapristone extended-release compositions and methods

Publications (3)

Publication Number Publication Date
JP2017537883A JP2017537883A (ja) 2017-12-21
JP2017537883A5 true JP2017537883A5 (enExample) 2018-12-27
JP6655075B2 JP6655075B2 (ja) 2020-02-26

Family

ID=56014429

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017520520A Expired - Fee Related JP6655075B2 (ja) 2014-11-17 2015-11-16 オナプリストン持続放出組成物および方法

Country Status (11)

Country Link
US (3) US10786461B2 (enExample)
EP (1) EP3247362A4 (enExample)
JP (1) JP6655075B2 (enExample)
KR (1) KR20170084086A (enExample)
CN (2) CN113559075A (enExample)
AU (2) AU2015350241B2 (enExample)
CA (1) CA2966753A1 (enExample)
HK (1) HK1246653A1 (enExample)
MX (1) MX391191B (enExample)
RU (1) RU2017112748A (enExample)
WO (1) WO2016081383A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2966753A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
JP2019503353A (ja) 2015-12-15 2019-02-07 コンテキスト・バイオファーマ・インコーポレイテッド 非晶質オナプリストン組成物およびそれを作製する方法
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8502612A1 (es) 1983-06-15 1985-02-01 Schering Ag Procedimiento para la preparacion de 13a-alquilgonanos
DE3321826A1 (de) 1983-06-15 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 13(alpha)-alkylgonane, deren herstellung und diese enthaltende pharmazeutische praeparate
US4780461A (en) 1983-06-15 1988-10-25 Schering Aktiengesellschaft 13α-alkyl-gonanes, their production, and pharmaceutical preparations containing same
US4742000A (en) 1986-05-02 1988-05-03 University Of Chicago Antibody to human progesterone receptor and diagnostic materials and methods
DE3630030A1 (de) 1986-09-01 1988-03-03 Schering Ag 13(alpha)-alkylgonan-(delta)(pfeil hoch)9(pfeil hoch)(pfeil hoch)((pfeil hoch)(pfeil hoch)1(pfeil hoch)1(pfeil hoch))(pfeil hoch)-5,10-epoxide
US4774236A (en) 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IE60780B1 (en) 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE3822770A1 (de) 1988-07-01 1990-01-04 Schering Ag 13-alkyl-11ss-phenylgonane
US5283190A (en) 1989-07-31 1994-02-01 Traish Adbulmaged M Specific monoclonal antibodies against a defined epitope of progesterone receptor and methods for their use
DE4008584A1 (de) 1990-03-15 1991-09-26 Schering Ag Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese)
US5141961A (en) 1991-06-27 1992-08-25 Richrdson-Vicks Inc. Process for solubilizing difficulty soluble pharmaceutical actives
MX9301121A (es) 1992-03-02 1993-09-01 Schering Ag Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina.
CN1053450C (zh) 1992-11-19 2000-06-14 北京第三制药厂 17位取代11β-取代芳香基-4,9-雌甾二烯类化合物的全合成法
DE4332283A1 (de) 1993-09-20 1995-04-13 Jenapharm Gmbh Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH10507461A (ja) * 1994-10-24 1998-07-21 シエーリング アクチエンゲゼルシヤフト 必要に応じて女性の稔性を調節するための競合的プロゲステロン拮抗物質
US5759577A (en) 1995-01-17 1998-06-02 American Home Products Corporation Controlled release of steroids from sugar coatings
US6900193B1 (en) 1996-05-01 2005-05-31 The United States Of America As Represented By The Department Of Health And Human Services Structural modification of 19-norprogesterone I: 17-α-substituted-11-β-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
US5962444A (en) 1998-05-29 1999-10-05 Research Triangle Institute 17β-nitro-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
US6537584B1 (en) 1999-11-12 2003-03-25 Macromed, Inc. Polymer blends that swell in an acidic environment and deswell in a basic environment
WO2001089566A1 (en) 2000-05-19 2001-11-29 Genentech, Inc. Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
US6750015B2 (en) 2000-06-28 2004-06-15 Kathryn B. Horwitz Progesterone receptor-regulated gene expression and methods related thereto
UY26966A1 (es) 2000-10-18 2002-06-20 Schering Ag Uso de antiprogestinas para la inducción de apoptosis en una célula
US7381976B2 (en) 2001-03-13 2008-06-03 Triton Thalassic Technologies, Inc. Monochromatic fluid treatment systems
AUPR546801A0 (en) 2001-06-05 2001-06-28 Commonwealth Scientific And Industrial Research Organisation Recombinant antibodies
US7105642B2 (en) 2001-08-03 2006-09-12 Cell Signalling Technology, Inc. Monoclonal antibodies specific for phosphorylated estrogen receptor alpha (Ser118) and uses thereof
US20040121304A1 (en) 2001-12-21 2004-06-24 Ulrike Fuhrmann Method for screening for progesterone receptor isoform-specific ligands and for tissue-selective progesterone receptor ligands
JP2006519255A (ja) 2003-02-28 2006-08-24 アメリカ合衆国 17α−アセトキシ−11β−(4−N,N−ジメチルアミノフェニル)−19−ノルプレグナ−4,9−ジエン−3,20−ジオンの製造方法、その中間体及びそのような中間体の製造方法
US20040265371A1 (en) 2003-06-25 2004-12-30 Looney Dwayne Lee Hemostatic devices and methods of making same
US7247625B2 (en) * 2003-10-09 2007-07-24 Wyeth 6-amino-1,4-dihydro-benzo[d][1,3] oxazin-2-ones and analogs useful as progesterone receptor modulators
ES2360806T3 (es) 2004-07-09 2011-06-09 The Population Council, Inc. Composiciones de liberación prolongada que contienen moduladores de receptores de progesterona.
WO2006036726A1 (en) 2004-09-22 2006-04-06 Tripath Imaging, Inc. Methods and computer program products for analysis and optimization of marker candidates for cancer prognosis
CA2604218A1 (en) 2005-04-20 2006-10-26 Pfizer Limited Pyrazole derivatives as progesterone receptor antagonists
EP2021499A4 (en) 2005-12-16 2010-02-17 Univ Leland Stanford Junior FUNCTIONAL ARRAYS FOR THE IDENTIFICATION OF ELEMENTS FOR GENE PRESSION REGULATION WITH HIGH THROUGHPUT
US20070167971A1 (en) 2006-01-17 2007-07-19 Raymond Huey Devices and methods for promoting the formation of blood clots in esophageal varices
US20070166372A1 (en) 2006-01-19 2007-07-19 Mai De Ltd. Preparation of solid coprecipitates of amorphous valsartan
WO2007098381A2 (en) 2006-02-17 2007-08-30 Janssen Pharmaceutica N.V. 11-phosphorous steroid derivatives useful as progesterone receptor modulators
DE102006054535A1 (de) 2006-11-15 2008-05-21 Bayer Schering Pharma Aktiengesellschaft Progesteronrezeptorantagonisten
WO2008128783A2 (en) 2007-04-24 2008-10-30 Dsm Ip Assets B.V. Photochemical process for the preparation of a previtamin d
CA2596204C (en) 2007-08-07 2019-02-26 Historx, Inc. Method and system for determining an optimal dilution of a reagent
WO2009025759A1 (en) 2007-08-17 2009-02-26 Progenics Pharmaceuticals (Nevada), Inc. Tight junction proteins associated with infection and entry of hepatitis c virus (hcv), methods and uses thereof
EP2209493A2 (en) * 2007-10-12 2010-07-28 Novartis AG Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
EA018974B9 (ru) 2008-02-05 2014-04-30 Харбор Терапьютикс, Инк. Твердые лекарственные формы
TW201002736A (en) 2008-04-28 2010-01-16 Repros Therapeutics Inc Compositions and methods for treating progesterone-dependent conditions
TWI539953B (zh) 2008-04-28 2016-07-01 瑞波若斯治療學公司 用於治療乳癌之組成物和方法
US8744695B2 (en) 2009-03-27 2014-06-03 Komatsu Ltd. Fuel consumption saving control device for work vehicle and fuel consumption saving method for work vehicle
US9074002B2 (en) 2009-04-27 2015-07-07 Cold Spring Harbor Laboratory PTP1B inhibitors
US20110003753A1 (en) 2009-06-01 2011-01-06 Samuel Waxman Cancer Research Foundation COMPOSITIONS AND METHODS FOR DISRUPTING THE FUNCTION OF THE TRANSCRIPTIONAL REPRESSOR COMPONENT Sin3A-PAH2 DOMAIN TO INDUCE DIFFERENTIATION AND GROWTH INHIBITION IN BREAST CANCER
JP6013911B2 (ja) 2009-07-15 2016-10-25 シーティーアイ・バイオファーマ・コーポレーションCTI BioPharma Corp. 9e−15−(2−ピロリジン−1−イル−エトキシ)−7,12,25−トリオキサ−19,21,24−トリアザ−テトラシクロ[18.3.1.1(2,5).1(14,18)]ヘキサコサ−1(24),2,4,9,14,16,18(26),20,22−ノナエンのクエン酸塩
US20110293511A1 (en) 2009-09-29 2011-12-01 Terrance Grant Johns Specific binding proteins and uses thereof
US8261855B2 (en) * 2009-11-11 2012-09-11 Flanders Electric, Ltd. Methods and systems for drilling boreholes
US9295649B2 (en) 2009-12-15 2016-03-29 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
EP2550288A1 (en) * 2010-03-22 2013-01-30 Repros Therapeutics Inc. Compositions and methods for non-toxic delivery of antiprogestins
DK2638163T3 (en) 2010-11-12 2017-07-24 Massachusetts Gen Hospital POLYCOMB-ASSOCIATED NON-CODING RNAs
EP2651400B2 (en) 2010-12-16 2023-01-18 Amgen (Europe) GmbH Controlled release oral dosage forms of poorly soluble drugs and uses thereof
DK2655621T3 (en) 2010-12-20 2018-08-13 Massachusetts Gen Hospital Polycomb-associated non-coding RNAS
WO2012122514A1 (en) 2011-03-09 2012-09-13 Centrose, Llc Extracellular targeted drug conjugates
PL2683384T3 (pl) * 2011-03-11 2016-06-30 Celgene Corp Sposoby leczenia nowotworu z użyciem 3-(5-amino-2-metylo-4-okso-4h-chinazolin-3-ylo)piperydyno-2,6-dionu
US9618512B2 (en) 2011-04-15 2017-04-11 J-Pharma Co., Ltd. Biomarker for breast cancer
NZ706004A (en) 2011-05-13 2016-12-23 Ganymed Pharmaceuticals Ag Antibodies for treatment of cancer expressing claudin 6
US20130029953A1 (en) 2011-07-28 2013-01-31 Klaus Nickisch Progesterone antagonists
PH12014500683A1 (en) 2011-10-04 2014-05-12 Invivis Pharmaceuticals Inc Methods and systems for identfying and treating anti-progestin sensitive tumors
US10039806B2 (en) 2011-12-08 2018-08-07 Fundacion Sales Methods and compositions for treating antiprogestin-resistant cancers
US20130338016A1 (en) 2012-04-17 2013-12-19 Vala Sciences, Inc. Method For Integrated Pathology Diagnosis And Digital Biomarker Pattern Analysis
EP2841594A1 (en) 2012-04-27 2015-03-04 Regents of the University of Minnesota Breast cancer prognosis, prediction of progesterone receptor subtype and!prediction of response to antiprogestin treatment based on gene expression
AU2013295815A1 (en) 2012-07-24 2015-02-05 Cedars-Sinai Medical Center A novel method to detect resistance to chemotherapy in patients with lung cancer
AU2013358968B2 (en) 2012-12-13 2017-12-21 Warsaw Orthopedic, Inc. Compositions and methods comprising polyethylene glycol and magnesium for treatment of neuronal injury
CA2904116C (en) * 2013-03-12 2021-09-14 Arno Therapeutics Onapristone polymorphic forms and methods of use
US20140363425A1 (en) 2013-03-13 2014-12-11 J. Dinny Graham Systems and methods for identifying cancers having activated progesterone receptors
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
CN103483449A (zh) 2013-08-20 2014-01-01 东北农业大学 两种scFv抗体、其编码基因及其在制备治疗或预防鸡传染性法氏囊病制剂中的应用
AU2015243969A1 (en) 2014-04-08 2016-09-01 Context Biopharma Inc. Systems and methods for identifying progesterone receptor subtypes
CA2966753A1 (en) 2014-11-17 2016-05-26 Arno Therapeutics, Inc. Onapristone extended-release compositions and methods
WO2016154203A1 (en) 2015-03-23 2016-09-29 Evestra, Inc. Novel cytotoxic agents that preferentially target leukemia inhibitory factor (lif) for the treatment of malignancies and as new contraceptive agents
AU2016326657B2 (en) 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
JP2019503353A (ja) 2015-12-15 2019-02-07 コンテキスト・バイオファーマ・インコーポレイテッド 非晶質オナプリストン組成物およびそれを作製する方法
JP2019513706A (ja) 2016-03-21 2019-05-30 コンテキスト・バイオファーマ・インコーポレイテッド オナプリストン代謝物質組成物及び方法
CA3022961A1 (en) 2016-05-02 2017-11-09 Tetragenetics, Inc. Anti-kv1.3 antibodies, and methods of production and use thereof
WO2018067198A1 (en) 2016-10-03 2018-04-12 The Regents Of The University Of California Inhibitory antibodies and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2009537538A5 (enExample)
RU2018127873A (ru) Получение и составление композиции, содержащей ингибитор mek
CY1118839T1 (el) Επικαλυμμενη φαρμακευτικη συνθεση που περιεχει ρεγοραφενιμπη
JP2013507408A5 (enExample)
JP2017537883A5 (enExample)
JP2015510916A5 (enExample)
NZ628392A (en) Use of a pyrazole derivative in the treatment of acute exacerbations of chronic obstructive pulmonary disease
AR100977A1 (es) Formulación compuesta para la administración oral que comprende ezetimiba y rosuvastatina, y un proceso para su preparación
JP2016532632A5 (enExample)
JP2019151627A5 (enExample)
CN110023286A (zh) 作为ccr2/ccr5受体拮抗剂的联苯化合物
JP2017520619A5 (enExample)
JP2015129175A5 (enExample)
JP2015509917A5 (enExample)
JP2017014205A5 (enExample)
CN104870437A (zh) 三嗪化合物、其药用盐、异构体或水合物及其药物组合物
RU2011133893A (ru) Лекарственная форма замедленного высвобождения глюкозамина
WO2015044952A3 (en) Tramadol hydrochloride and paracetamol orally disintegrating composition and process for preparing the same
EA202090809A1 (ru) Высокодозовый состав валбеназина и композиции, способы и наборы, связанные с ним
CN301730099S (zh) 豆浆机壳体(禅花纹)
CN302060046S (zh) 钢木会议桌(ea78)
CN301427419S (zh) 淋浴房花洒(p26800)
CN302104974S (zh) 智能炒菜机(21hs76)
CN302389864S (zh) 衣帽架(j002)
CN302465771S (zh) 药品包装盒(盐酸二甲双胍缓释片)