|
JPS63152393A
(ja)
|
1986-07-03 |
1988-06-24 |
Takeda Chem Ind Ltd |
グリコシル誘導体
|
|
US5231012A
(en)
|
1989-06-28 |
1993-07-27 |
Schering Corporation |
Nucleic acids encoding cytokine synthesis inhibitory factor (interleukin-10)
|
|
US6217857B1
(en)
|
1989-06-28 |
2001-04-17 |
Schering Corporation |
Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
DK0567586T3
(da)
|
1991-01-16 |
1995-12-04 |
Schering Corp |
Anvendelse af interleukin-10 ved adoptiv immunterapi af cancer
|
|
HU218598B
(hu)
|
1991-01-16 |
2000-10-28 |
Schering Corp. |
Eljárás interleukin-10-et tartalmazó, tumorok kezelésére szolgáló gyógyszerkészítmények előállítására
|
|
US5624823A
(en)
|
1991-11-22 |
1997-04-29 |
The General Hospital Corporation |
DNA encoding procine interleukin-10
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
WO1994017773A2
(en)
|
1993-02-01 |
1994-08-18 |
Université Libre de Bruxelles |
Use of a pharmaceutical composition comprising an effective amount of interleukin-10, an analog and/or an agonist of interleukin-10
|
|
US5328989A
(en)
|
1993-03-05 |
1994-07-12 |
Schering-Plough |
Purification of human interleukin-10 from a cell culture medium
|
|
US5552303A
(en)
*
|
1993-03-08 |
1996-09-03 |
Immunex Corporation |
DNA encoding epithelium-derived T-cell factor
|
|
US5665345A
(en)
|
1993-05-24 |
1997-09-09 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of inhibiting viral replication using IL-10
|
|
SK8396A3
(en)
|
1993-07-26 |
1997-03-05 |
Schering Corp |
Antagonists and agonists of human interleukin-10
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
EP0740552A1
(en)
|
1994-01-20 |
1996-11-06 |
Schering Corporation |
Use of il-10 to stimulate peripheral blood mononuclear cell cytolytic activity
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
US6410008B1
(en)
|
1994-12-12 |
2002-06-25 |
Beth Israel Hospital Association |
Chimeric IL-10 proteins and uses thereof
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US7008624B1
(en)
*
|
1995-02-22 |
2006-03-07 |
Immunex Corporation |
Antagonists of interleukin-15
|
|
US5866134A
(en)
|
1995-03-24 |
1999-02-02 |
Schering Corporation |
Method for enhancing the antibody response to specific antigens with Interleukin-10
|
|
US5770190A
(en)
|
1995-07-14 |
1998-06-23 |
Schering Corporation |
Method of treatment of acute leukemia with inteleukin-10
|
|
GB2304047A
(en)
|
1995-08-09 |
1997-03-12 |
Univ Manchester |
Pharmaceutical compositions containing cytokines
|
|
US5744451A
(en)
|
1995-09-12 |
1998-04-28 |
Warner-Lambert Company |
N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
CA2252557A1
(en)
*
|
1996-04-26 |
1997-11-06 |
Beth Israel Deaconess Medical Center, Inc. |
Antagonists of interleukin-15
|
|
US5945097A
(en)
|
1996-09-06 |
1999-08-31 |
Schering Corporation |
Method for lowering cholesterol levels with interleukin-10
|
|
US5989867A
(en)
|
1996-09-23 |
1999-11-23 |
Knappe; Andrea |
DNA encoding IL-10-like homologue; related reagents
|
|
US6660258B1
(en)
|
1997-05-09 |
2003-12-09 |
Pharma Pacific Pty Ltd |
Oromucosal cytokine compositions and uses thereof
|
|
EP1881005B1
(en)
|
1997-07-14 |
2013-04-03 |
Bolder Biotechnology, Inc. |
Derivatives of G-CSF and related proteins
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US6428985B1
(en)
|
1998-12-02 |
2002-08-06 |
The Regents Of The University Of Michigan |
Immunosuppressive structural definition of IL-10
|
|
US7666400B2
(en)
|
2005-04-06 |
2010-02-23 |
Ibc Pharmaceuticals, Inc. |
PEGylation by the dock and lock (DNL) technique
|
|
AU5827000A
(en)
|
1999-07-16 |
2001-02-05 |
Maria Teresa Bejarano |
Viral il-10 uses
|
|
US6989377B2
(en)
|
1999-12-21 |
2006-01-24 |
Wisconsin Alumni Research Foundation |
Treating vitamin D responsive diseases
|
|
AU2001231532A1
(en)
|
2000-02-11 |
2001-08-20 |
Maxygen Aps |
Improved interleukin 10
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
US7052686B2
(en)
|
2000-09-29 |
2006-05-30 |
Schering Corporation |
Pegylated interleukin-10
|
|
US6838452B2
(en)
|
2000-11-24 |
2005-01-04 |
Vascular Biogenics Ltd. |
Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis
|
|
EP1234583A1
(en)
|
2001-02-23 |
2002-08-28 |
F. Hoffmann-La Roche Ag |
PEG-conjugates of HGF-NK4
|
|
GB0212648D0
(en)
|
2002-05-31 |
2002-07-10 |
Immunoclin Lab Ltd |
Treatment with cytokines
|
|
AU2003263552A1
(en)
|
2002-09-09 |
2004-03-29 |
Nautilus Biotech |
Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
|
|
AU2003280315A1
(en)
|
2002-11-14 |
2004-06-03 |
Maxygen, Inc. |
Conjugates of interleukin-10 and polymers
|
|
DK1565183T3
(da)
|
2002-11-29 |
2008-12-01 |
Maria Grazia Roncarolo |
Rapamycin og IL-10 til behandling af autoimmune sygdomme
|
|
WO2004056850A2
(en)
|
2002-12-19 |
2004-07-08 |
Vib Vzw |
Mutant proteins showing increased secretion
|
|
BR0316880A
(pt)
|
2002-12-23 |
2005-10-25 |
Wyeth Corp |
Anticorpos contra pd-1 e usos dos mesmos
|
|
TWI364295B
(en)
|
2002-12-26 |
2012-05-21 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
|
JP5466350B2
(ja)
|
2003-03-03 |
2014-04-09 |
ダイアックス、コープ |
HGFレセプター(cMet)を特異的に結合するペプチドおよびその使用
|
|
EP2261244A3
(en)
|
2003-04-15 |
2011-02-23 |
Glaxosmithkline LLC |
Human il-18 substitution mutants and their conjugates
|
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
|
WO2005007121A2
(en)
*
|
2003-07-18 |
2005-01-27 |
Massachusetts Institute Of Technology |
Mutant interleukin-2(il-2) polypeptides
|
|
DE602004025509D1
(de)
|
2003-11-28 |
2010-03-25 |
Univ Sydney |
Virales latentphasen-interleukin-10-(vii-10) und verwendungen davon
|
|
JP5744369B2
(ja)
*
|
2004-02-27 |
2015-07-08 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体
|
|
EP2336192A1
(en)
|
2004-03-11 |
2011-06-22 |
Fresenius Kabi Deutschland GmbH |
Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
|
|
WO2006017853A2
(en)
*
|
2004-08-11 |
2006-02-16 |
Beth Israel Deaconess Medical Center, Inc. |
Mutant interleukin-15-containing compositions and suppression of an immune response
|
|
US20060046961A1
(en)
|
2004-09-02 |
2006-03-02 |
Mckay William F |
Controlled and directed local delivery of anti-inflammatory compositions
|
|
CN100334112C
(zh)
|
2004-10-15 |
2007-08-29 |
上海海欣生物技术有限公司 |
人白细胞介素15与Fc融合蛋白
|
|
GB0500643D0
(en)
|
2005-01-13 |
2005-02-23 |
Renovo Ltd |
Medicaments
|
|
UY29460A1
(es)
|
2005-04-08 |
2006-11-30 |
Noxxon Pharma Ag |
Acidos nucleicos de union a ghrelin
|
|
WO2006119170A2
(en)
|
2005-05-02 |
2006-11-09 |
Avigen, Inc. |
Use of cytokine-derived peptides in treatment of pain and neurodegenerative disease
|
|
JP4992025B2
(ja)
|
2005-05-31 |
2012-08-08 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイト |
変異体il−10
|
|
US8945857B2
(en)
|
2005-07-01 |
2015-02-03 |
John Schrader |
Methods of isolating cells and generating monoclonal antibodies
|
|
JP5364375B2
(ja)
|
2005-10-04 |
2013-12-11 |
ザイモジェネティクス リミテッド ライアビリティ カンパニー |
Il−29の生産および精製の方法
|
|
US7939056B2
(en)
|
2005-11-14 |
2011-05-10 |
The Brigham And Women's Hospital, Inc. |
Interleukin-10 compositions for the treatment of adenocarcinomas
|
|
US7868139B2
(en)
|
2006-01-24 |
2011-01-11 |
Uab Research Foundation |
Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases
|
|
NZ597098A
(en)
|
2006-09-28 |
2013-05-31 |
Merck Sharp & Dohme |
Use of pegylated il-10 to treat cancer
|
|
WO2008041953A2
(en)
|
2006-10-05 |
2008-04-10 |
Agency For Science, Technology And Research |
Dengue diagnosis and treatment
|
|
JP5220025B2
(ja)
|
2006-12-04 |
2013-06-26 |
プロメディオール, インコーポレイテッド |
線維症疾患を処置するための併用療法
|
|
AU2008206077A1
(en)
|
2007-01-19 |
2008-07-24 |
Kai Pharmaceuticals, Inc. |
Modifications of peptide compositions to increase stability and delivery efficiency
|
|
CN108948177B
(zh)
*
|
2007-05-11 |
2022-04-22 |
阿尔托生物科学有限公司 |
融合分子与il-15变异体
|
|
AU2008281913B2
(en)
|
2007-07-31 |
2013-11-07 |
Affibody Ab |
New albumin binding compositions, methods and uses
|
|
WO2009036568A1
(en)
|
2007-09-19 |
2009-03-26 |
University Health Network |
Methods and compositions for treating tumors and viral infections
|
|
EP2200649A4
(en)
|
2007-10-19 |
2012-09-26 |
Univ California |
COMPOSITIONS AND METHODS FOR IMPROVING INFLAMMATION OF SN, PSYCHOSIS, DELI, PTSD OR PTSD
|
|
GB0724231D0
(en)
|
2007-12-12 |
2008-01-30 |
Renono Ltd |
Methods for inhibiting scarring
|
|
US20090311187A1
(en)
|
2008-05-29 |
2009-12-17 |
Bristol-Myers Squibb Company |
Methods for predicting patient response to modulation of the Co-stimulatory pathway
|
|
WO2010022227A1
(en)
|
2008-08-20 |
2010-02-25 |
Schering Corporation |
Methods for monitoring il-10 therapy
|
|
JP5888980B2
(ja)
|
2008-12-17 |
2016-03-22 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
モノ−およびジ−pegil10の製造および用途
|
|
EP3421491A3
(en)
|
2009-10-30 |
2019-03-27 |
Albumedix Ltd |
Albumin variants
|
|
US9170262B2
(en)
|
2010-06-16 |
2015-10-27 |
Abbvie, Inc. |
Comparison of protein samples
|
|
US9084761B2
(en)
*
|
2010-07-09 |
2015-07-21 |
The Regents Of The University Of California |
Use of interleukin-15 to treat cardiovascular diseases
|
|
EP2933262B1
(en)
|
2010-07-09 |
2018-05-02 |
Affibody AB |
Polypeptides
|
|
BR112013007442A2
(pt)
|
2010-09-28 |
2019-09-24 |
Amylin Pharmaceuticals Llc |
polipeptídeos construídos tendo duração de ação realçada
|
|
ES2630031T3
(es)
|
2010-09-28 |
2017-08-17 |
Aegerion Pharmaceuticals, Inc. |
Un polipéptido de leptina pinnípedo-humano quimérico con solubilidad aumentada
|
|
CN102145178B
(zh)
|
2011-04-15 |
2012-09-26 |
北京凯因科技股份有限公司 |
Peg化白介素15
|
|
EP2537933A1
(en)
*
|
2011-06-24 |
2012-12-26 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
An IL-15 and IL-15Ralpha sushi domain based immunocytokines
|
|
CN104080917B
(zh)
*
|
2011-09-29 |
2016-11-02 |
国家健康与医学研究院 |
用突变体BaEV糖蛋白假型化的慢病毒载体
|
|
BR112014018575A2
(pt)
|
2012-01-26 |
2017-07-04 |
Amgen Inc |
polipetídeos de fator de diferenciação de crescimento 15 (gdf-15)
|
|
WO2013130913A1
(en)
|
2012-02-29 |
2013-09-06 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates and their uses
|
|
WO2014172392A1
(en)
|
2013-04-18 |
2014-10-23 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
MX2016005915A
(es)
|
2013-11-11 |
2016-12-16 |
Armo Biosciences Inc |
Metodos de uso de interleucina-10 para tratar enfermedades y trastornos.
|
|
MA39711A
(fr)
|
2014-04-03 |
2015-10-08 |
Nektar Therapeutics |
Conjugués d'une fraction d'il-15 et d'un polymère
|