JP2016526014A5 - - Google Patents
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- JP2016526014A5 JP2016526014A5 JP2016510767A JP2016510767A JP2016526014A5 JP 2016526014 A5 JP2016526014 A5 JP 2016526014A5 JP 2016510767 A JP2016510767 A JP 2016510767A JP 2016510767 A JP2016510767 A JP 2016510767A JP 2016526014 A5 JP2016526014 A5 JP 2016526014A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- antibody
- substitution
- helix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 114
- 238000006467 substitution reaction Methods 0.000 claims 38
- 125000000539 amino acid group Chemical group 0.000 claims 32
- 239000008194 pharmaceutical composition Substances 0.000 claims 29
- 125000003275 alpha amino acid group Chemical group 0.000 claims 23
- 108091005601 modified peptides Proteins 0.000 claims 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 19
- 208000035475 disorder Diseases 0.000 claims 11
- 230000004048 modification Effects 0.000 claims 10
- 238000012986 modification Methods 0.000 claims 10
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 238000012216 screening Methods 0.000 claims 6
- 230000004071 biological effect Effects 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000000704 physical effect Effects 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 102000003814 Interleukin-10 Human genes 0.000 claims 4
- 108090000174 Interleukin-10 Proteins 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 238000007792 addition Methods 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 230000037430 deletion Effects 0.000 claims 4
- 230000005847 immunogenicity Effects 0.000 claims 4
- 238000000099 in vitro assay Methods 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 230000000069 prophylactic effect Effects 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 230000002411 adverse Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000003993 interaction Effects 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 102000009027 Albumins Human genes 0.000 claims 2
- 108010088751 Albumins Proteins 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 claims 2
- 102000007562 Serum Albumin Human genes 0.000 claims 2
- 108010071390 Serum Albumin Proteins 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000001516 cell proliferation assay Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 102000052620 human IL10 Human genes 0.000 claims 2
- 208000026278 immune system disease Diseases 0.000 claims 2
- 238000000126 in silico method Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000005462 in vivo assay Methods 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000019838 Blood disease Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 206010014476 Elevated cholesterol Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 150000001720 carbohydrates Chemical group 0.000 claims 1
- 150000004665 fatty acids Chemical group 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 150000004676 glycans Polymers 0.000 claims 1
- 208000014951 hematologic disease Diseases 0.000 claims 1
- 208000018706 hematopoietic system disease Diseases 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 150000002632 lipids Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 150000004804 polysaccharides Polymers 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 230000001732 thrombotic effect Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361815657P | 2013-04-24 | 2013-04-24 | |
| US61/815,657 | 2013-04-24 | ||
| PCT/US2014/035201 WO2014176373A2 (en) | 2013-04-24 | 2014-04-23 | Interleukin-10 compositions and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016526014A JP2016526014A (ja) | 2016-09-01 |
| JP2016526014A5 true JP2016526014A5 (enExample) | 2017-06-01 |
Family
ID=51792509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016510767A Pending JP2016526014A (ja) | 2013-04-24 | 2014-04-23 | インターロイキン−１０組成物及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20160068583A1 (enExample) |
| EP (1) | EP2989240A4 (enExample) |
| JP (1) | JP2016526014A (enExample) |
| AU (1) | AU2014257123A1 (enExample) |
| CA (1) | CA2908208A1 (enExample) |
| HK (1) | HK1215595A1 (enExample) |
| WO (1) | WO2014176373A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011302645B2 (en) | 2010-09-15 | 2015-02-26 | Applied Molecular Transport, Llc | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| CA2914837A1 (en) | 2013-06-17 | 2014-12-24 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| US10010588B2 (en) * | 2013-08-30 | 2018-07-03 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating hyperlipidemia |
| KR20160079114A (ko) | 2013-11-11 | 2016-07-05 | 아르모 바이오사이언시스 인코포레이티드 | 질환 및 장애를 치료하기 위한 인터류킨-10을 사용하는 방법 |
| EP3139965B1 (en) | 2014-05-07 | 2021-09-29 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| EP3233920B1 (en) | 2014-12-19 | 2020-08-26 | Alkermes, Inc. | Single chain fc fusion proteins |
| US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
| WO2016191587A1 (en) | 2015-05-28 | 2016-12-01 | Armo Biosciences, Inc. | Pegylated interleukin-10 for use in treating cancer |
| CA2995120A1 (en) | 2015-08-25 | 2017-03-02 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| WO2017087784A1 (en) * | 2015-11-18 | 2017-05-26 | Duke University | Tumor infiltrating lymphocytes for treatment of cancer |
| WO2018005226A2 (en) * | 2016-06-22 | 2018-01-04 | Alkermes, Inc. | Compositions and methods for modulating il-10 immunostimulatory and anti-inflammatory properties |
| US10738338B2 (en) | 2016-10-18 | 2020-08-11 | The Research Foundation for the State University | Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate |
| US10857136B2 (en) * | 2017-03-14 | 2020-12-08 | Sjt Molecular Research, Sl | Compounds for use in the prevention and/or treatment of non-alcoholic fat liver disease and non-alcoholic steatohepatitis |
| CN111315398A (zh) | 2017-11-10 | 2020-06-19 | 阿尔莫生物科技股份有限公司 | 白介素-10与免疫检查点途径抑制剂的组合的组合物和使用方法 |
| JP7097465B2 (ja) | 2018-06-19 | 2022-07-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | キメラ抗原受容体細胞療法と併用するｉｌ－１０剤の組成およびその使用方法 |
| SG11202104734YA (en) | 2018-11-07 | 2021-06-29 | Applied Molecular Transport Inc | Cholix-derived carriers for oral delivery of heterologous payload |
| TW202033766A (zh) * | 2018-11-26 | 2020-09-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種人白細胞介素１０變體及其衍生物 |
| CN113811549A (zh) | 2019-02-21 | 2021-12-17 | Xencor股份有限公司 | 非靶向和靶向性il-10 fc融合蛋白 |
| EP3930687A4 (en) | 2019-02-25 | 2023-06-07 | The University of Chicago | METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND AUTOIMMUNE CONDITIONS USING ECM AFFINITY PEPTIDES LINKED TO ANTI-INFLAMMATORY AGENTS |
| BR102019007048A8 (pt) * | 2019-04-05 | 2023-05-09 | Univ Federal De Uberlandia | Combinação de peptídeos sintéticos com afinidade ao receptor de tgf-beta e com afinidade ao receptor de il-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas |
| MX2022001975A (es) | 2019-08-16 | 2022-03-11 | Applied Molecular Transport Inc | Composiciones, formulaciones y produccion y purificacion de interleucinas. |
| KR20260083444A (ko) | 2019-11-25 | 2026-06-05 | 알케르메스,인코포레이티드 | 치환된 마크로사이클릭 화합물 및 관련 치료 방법 |
| GB202003428D0 (en) * | 2020-03-10 | 2020-04-22 | Univ Dundee | IL-10 mutiens |
| IL330191A (en) | 2020-06-26 | 2026-08-01 | Amgen Inc | IL-10 mutants and their fusion proteins |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| WO2023102493A2 (en) * | 2021-12-01 | 2023-06-08 | Synthekine, Inc. | Il10 variants and uses thereof |
| WO2024131600A1 (zh) * | 2022-12-24 | 2024-06-27 | 广东菲鹏制药股份有限公司 | Il10突变体、融合蛋白和药物 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110413A0 (en) * | 1993-07-26 | 1994-10-21 | Schering Corp | Agonists and antagonists of human interleukin-10 |
| ATE375363T1 (de) * | 1997-07-14 | 2007-10-15 | Bolder Biotechnology Inc | Derivate des wachstumshormons und verwandte proteine |
| US6428985B1 (en) * | 1998-12-02 | 2002-08-06 | The Regents Of The University Of Michigan | Immunosuppressive structural definition of IL-10 |
| AU2001231532A1 (en) * | 2000-02-11 | 2001-08-20 | Maxygen Aps | Improved interleukin 10 |
| US20030186386A1 (en) * | 2000-02-11 | 2003-10-02 | Hansen Christian Karsten | Interleukin 10 |
| NZ522847A (en) * | 2000-05-16 | 2004-11-26 | Bolder Biotechnology Inc | Methods for refolding proteins containing free cysteine residues |
| US7052686B2 (en) * | 2000-09-29 | 2006-05-30 | Schering Corporation | Pegylated interleukin-10 |
| WO2004022593A2 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| WO2004044006A1 (en) * | 2002-11-14 | 2004-05-27 | Maxygen, Inc. | Conjugates of interleukin-10 and polymers |
| WO2004056850A2 (en) * | 2002-12-19 | 2004-07-08 | Vib Vzw | Mutant proteins showing increased secretion |
| RS20050501A (sr) * | 2002-12-26 | 2007-08-03 | Mountain View Pharmaceuticals Inc., | Polimerni konjugati citokina,hemokina,faktora rasta, polipeptidnih hormona i njihovih antagonista sa očuvanom aktivnošću vezivanja receptora |
| DE602006011311D1 (de) * | 2005-05-31 | 2010-02-04 | Univ Colorado | Il-10 mutante |
| EP2343363A1 (en) * | 2005-07-01 | 2011-07-13 | John Schrader | Methods of isolating cells and generating monoclonal antibodies involving single epitope multiple staining |
| WO2007087576A2 (en) * | 2006-01-24 | 2007-08-02 | The Uab Research Foundation | Compositions and methods for the identification and treatment of immune-mediated inflammatory diseases |
| WO2009062151A1 (en) * | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
| AU2010323037B2 (en) * | 2009-11-30 | 2015-01-29 | Biotest Ag | Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE) |
| US20150038678A1 (en) * | 2012-02-29 | 2015-02-05 | Ambrx, Inc. | Interleukin-10 Polypeptide Conjugates and Their Uses |
-
2014
- 2014-04-23 JP JP2016510767A patent/JP2016526014A/ja active Pending
- 2014-04-23 US US14/779,928 patent/US20160068583A1/en not_active Abandoned
- 2014-04-23 AU AU2014257123A patent/AU2014257123A1/en not_active Abandoned
- 2014-04-23 WO PCT/US2014/035201 patent/WO2014176373A2/en not_active Ceased
- 2014-04-23 HK HK16102717.0A patent/HK1215595A1/zh unknown
- 2014-04-23 CA CA2908208A patent/CA2908208A1/en not_active Abandoned
- 2014-04-23 EP EP14788854.9A patent/EP2989240A4/en not_active Withdrawn
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