PE20212075A1 - PROTEINAS DE FUSION Fc IL-22 Y METODOS DE USO - Google Patents
PROTEINAS DE FUSION Fc IL-22 Y METODOS DE USOInfo
- Publication number
- PE20212075A1 PE20212075A1 PE2020000924A PE2020000924A PE20212075A1 PE 20212075 A1 PE20212075 A1 PE 20212075A1 PE 2020000924 A PE2020000924 A PE 2020000924A PE 2020000924 A PE2020000924 A PE 2020000924A PE 20212075 A1 PE20212075 A1 PE 20212075A1
- Authority
- PE
- Peru
- Prior art keywords
- methods
- fusion protein
- composition
- ibd
- fusion proteins
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Water Supply & Treatment (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invencion se refiere a una composicion que comprende una proteina de fusion de Fc e interleucina-22 (IL-22), en donde la proteina de fusion Fc IL-22 comprende un polipeptido de IL-22 glicosilado en los residuos Asn21, Asn35, Asn64 y/o Asn143 de la SEQ ID NO: 4, adicionalmente enlazado a una region Fc mediante un enlazador, y en donde la composicion tiene un contenido de acido sialico promedio en el rango de 8 a 12 moles de acido sialico por mol de la proteina de fusion Fc IL-22.Tambien se refiere a metodos para producir y/o purificar la proteina de fusion Fc IL-22, metodos para seleccionar lotes de proteinas de fusion Fc IL-22 y metodos de uso de la composicion para el tratamiento de enfermedades como enfermedad intestinal inflamatoria (IBD), donde la IBD es colitis ulcerosa o enfermedad de Crohn.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862622767P | 2018-01-26 | 2018-01-26 | |
PCT/US2019/015277 WO2019148026A1 (en) | 2018-01-26 | 2019-01-25 | Il-22 fc fusion proteins and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20212075A1 true PE20212075A1 (es) | 2021-10-26 |
Family
ID=65441062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2020000924A PE20212075A1 (es) | 2018-01-26 | 2019-01-25 | PROTEINAS DE FUSION Fc IL-22 Y METODOS DE USO |
Country Status (21)
Country | Link |
---|---|
US (1) | US20200362003A1 (es) |
EP (1) | EP3743437A1 (es) |
JP (1) | JP7349995B2 (es) |
KR (1) | KR20200115546A (es) |
CN (1) | CN111655717A (es) |
AR (1) | AR114565A1 (es) |
AU (1) | AU2019212709A1 (es) |
BR (1) | BR112020013420A2 (es) |
CA (1) | CA3087339A1 (es) |
CL (2) | CL2020001944A1 (es) |
CO (1) | CO2020009402A2 (es) |
CR (1) | CR20200327A (es) |
IL (1) | IL275742A (es) |
MA (1) | MA51676A (es) |
MX (1) | MX2020007018A (es) |
PE (1) | PE20212075A1 (es) |
PH (1) | PH12020551019A1 (es) |
RU (1) | RU2020127792A (es) |
SG (1) | SG11202006259SA (es) |
TW (1) | TWI835772B (es) |
WO (1) | WO2019148026A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11510966B2 (en) | 2016-04-15 | 2022-11-29 | Evive Biotechnology (Shanghai) Ltd | Use of IL-22 in treating necrotizing enterocolitis |
CA3143633A1 (en) * | 2019-07-26 | 2021-02-04 | Matthew Kalo | Dosing for prevention or treatment of graft versus host disease (gvhd) with il-22 fc fusion proteins |
WO2021207662A1 (en) | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome |
WO2022073038A1 (en) * | 2020-10-02 | 2022-04-07 | Abbvie Inc. | Interleukin-22 (il-22) fusion proteins and uses thereof |
JP2023548045A (ja) | 2020-10-23 | 2023-11-15 | アッシャー バイオセラピューティクス, インコーポレイテッド | 免疫細胞機能をモジュレートするためのcd8抗原結合分子を有する融合物 |
AU2021396247A1 (en) * | 2020-12-09 | 2023-07-06 | Asher Biotherapeutics, Inc. | Fusions of mutant interleukin-10 polypeptides with antigen binding molecules for modulating immune cell function |
WO2023034758A1 (en) * | 2021-08-30 | 2023-03-09 | Cytoimmune Therapeutics, Inc. | Methods and compositions for cell expansion |
CN117603361A (zh) * | 2022-08-22 | 2024-02-27 | 复旦大学附属儿科医院 | 包含angptl3单抗的融合蛋白 |
WO2024075075A1 (en) | 2022-10-06 | 2024-04-11 | Renexxion Ireland Limited | Compounds, compositions and methods for treating inflammatory bowel disease |
WO2024096505A1 (ko) * | 2022-10-31 | 2024-05-10 | 삼성바이오에피스 주식회사 | 친화성 크로마토그래피를 통해 불순물을 제거하는 방법 |
WO2024130158A1 (en) * | 2022-12-16 | 2024-06-20 | Modernatx, Inc. | Lipid nanoparticles and polynucleotides encoding extended serum half-life interleukin-22 for the treatment of metabolic disease |
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-
2019
- 2019-01-25 CN CN201980010357.9A patent/CN111655717A/zh active Pending
- 2019-01-25 TW TW108102961A patent/TWI835772B/zh active
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- 2019-01-25 PE PE2020000924A patent/PE20212075A1/es unknown
- 2019-01-25 KR KR1020207023986A patent/KR20200115546A/ko not_active Application Discontinuation
- 2019-01-25 MA MA051676A patent/MA51676A/fr unknown
- 2019-01-25 EP EP19705616.1A patent/EP3743437A1/en active Pending
- 2019-01-25 RU RU2020127792A patent/RU2020127792A/ru unknown
- 2019-01-25 BR BR112020013420-1A patent/BR112020013420A2/pt unknown
- 2019-01-25 WO PCT/US2019/015277 patent/WO2019148026A1/en unknown
- 2019-01-25 CR CR20200327A patent/CR20200327A/es unknown
- 2019-01-25 JP JP2020537767A patent/JP7349995B2/ja active Active
- 2019-01-25 CA CA3087339A patent/CA3087339A1/en active Pending
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- 2019-01-25 MX MX2020007018A patent/MX2020007018A/es unknown
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2020
- 2020-06-29 IL IL275742A patent/IL275742A/en unknown
- 2020-06-29 PH PH12020551019A patent/PH12020551019A1/en unknown
- 2020-07-23 CL CL2020001944A patent/CL2020001944A1/es unknown
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- 2020-07-29 CO CONC2020/0009402A patent/CO2020009402A2/es unknown
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2021
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TW201938186A (zh) | 2019-10-01 |
CA3087339A1 (en) | 2019-08-01 |
IL275742A (en) | 2020-08-31 |
AR114565A1 (es) | 2020-09-23 |
BR112020013420A2 (pt) | 2020-12-01 |
RU2020127792A (ru) | 2022-02-28 |
CN111655717A (zh) | 2020-09-11 |
AU2019212709A1 (en) | 2020-08-13 |
KR20200115546A (ko) | 2020-10-07 |
CO2020009402A2 (es) | 2020-08-10 |
JP2021511297A (ja) | 2021-05-06 |
CL2020001944A1 (es) | 2020-10-23 |
CL2021001162A1 (es) | 2021-10-22 |
US20200362003A1 (en) | 2020-11-19 |
PH12020551019A1 (en) | 2021-05-31 |
TWI835772B (zh) | 2024-03-21 |
MA51676A (fr) | 2021-05-05 |
CR20200327A (es) | 2020-11-05 |
MX2020007018A (es) | 2020-09-07 |
EP3743437A1 (en) | 2020-12-02 |
WO2019148026A8 (en) | 2019-08-29 |
WO2019148026A1 (en) | 2019-08-01 |
SG11202006259SA (en) | 2020-08-28 |
JP7349995B2 (ja) | 2023-09-25 |
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