JP2017535586A5 - - Google Patents
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- JP2017535586A5 JP2017535586A5 JP2017528154A JP2017528154A JP2017535586A5 JP 2017535586 A5 JP2017535586 A5 JP 2017535586A5 JP 2017528154 A JP2017528154 A JP 2017528154A JP 2017528154 A JP2017528154 A JP 2017528154A JP 2017535586 A5 JP2017535586 A5 JP 2017535586A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- hydrogen
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 115
- 239000001257 hydrogen Substances 0.000 claims description 115
- 150000001875 compounds Chemical class 0.000 claims description 95
- 125000000217 alkyl group Chemical group 0.000 claims description 80
- 125000001072 heteroaryl group Chemical group 0.000 claims description 62
- 125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 claims description 60
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 57
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 55
- 150000002431 hydrogen Chemical group 0.000 claims description 54
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 53
- 125000003118 aryl group Chemical group 0.000 claims description 52
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
- 208000035475 disorder Diseases 0.000 claims description 23
- 229910052736 halogen Inorganic materials 0.000 claims description 23
- 150000002367 halogens Chemical group 0.000 claims description 23
- 125000000623 heterocyclic group Chemical group 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- 210000003169 central nervous system Anatomy 0.000 claims description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims description 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 239000002575 chemical warfare agent Substances 0.000 claims description 7
- 230000006378 damage Effects 0.000 claims description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 206010010904 Convulsion Diseases 0.000 claims description 5
- 239000003691 GABA modulator Substances 0.000 claims description 5
- 150000003431 steroids Chemical class 0.000 claims description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 4
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 4
- 208000019022 Mood disease Diseases 0.000 claims description 3
- 208000016285 Movement disease Diseases 0.000 claims description 3
- 208000002193 Pain Diseases 0.000 claims description 3
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 3
- 208000009205 Tinnitus Diseases 0.000 claims description 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 3
- 206010048010 Withdrawal syndrome Diseases 0.000 claims description 3
- 208000029560 autism spectrum disease Diseases 0.000 claims description 3
- 208000010877 cognitive disease Diseases 0.000 claims description 3
- 230000036461 convulsion Effects 0.000 claims description 3
- 230000036407 pain Effects 0.000 claims description 3
- 208000022821 personality disease Diseases 0.000 claims description 3
- 201000000980 schizophrenia Diseases 0.000 claims description 3
- 208000019116 sleep disease Diseases 0.000 claims description 3
- 208000020685 sleep-wake disease Diseases 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 claims description 3
- 201000009032 substance abuse Diseases 0.000 claims description 3
- 231100000736 substance abuse Toxicity 0.000 claims description 3
- 208000011117 substance-related disease Diseases 0.000 claims description 3
- 231100000886 tinnitus Toxicity 0.000 claims description 3
- 230000009529 traumatic brain injury Effects 0.000 claims description 3
- 208000026139 Memory disease Diseases 0.000 claims description 2
- 201000009916 Postpartum depression Diseases 0.000 claims description 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 2
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 125000001624 naphthyl group Chemical group 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 229930192474 thiophene Natural products 0.000 claims description 2
- 150000003852 triazoles Chemical class 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 235000020083 shōchū Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 description 40
- 0 C[C@@]1(CC[C@@](C)([C@@]2CC3)[C@]4(C)C3CC(C)(C)CC4)C(C(c(cccc3)c3F)=O)=*C[C@]12I Chemical compound C[C@@]1(CC[C@@](C)([C@@]2CC3)[C@]4(C)C3CC(C)(C)CC4)C(C(c(cccc3)c3F)=O)=*C[C@]12I 0.000 description 16
- 229910052799 carbon Inorganic materials 0.000 description 7
- 206010002091 Anaesthesia Diseases 0.000 description 5
- 206010039897 Sedation Diseases 0.000 description 5
- 230000037005 anaesthesia Effects 0.000 description 5
- 210000005036 nerve Anatomy 0.000 description 5
- 230000036280 sedation Effects 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 229940124597 therapeutic agent Drugs 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 description 2
- 208000009575 Angelman syndrome Diseases 0.000 description 2
- 208000001914 Fragile X syndrome Diseases 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 208000006289 Rett Syndrome Diseases 0.000 description 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 208000005809 status epilepticus Diseases 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- 108010066676 Abrin Proteins 0.000 description 1
- LKPVDGWWWXFWJJ-ROOJVTFQSA-N CC(CC1)(C(CC2)C(c(cc3)cc(C)c3F)O)[C@@H]2C(CC2)[C@H]1[C@@](C)(CC1)[C@@H]2C[C@]1(C)O Chemical compound CC(CC1)(C(CC2)C(c(cc3)cc(C)c3F)O)[C@@H]2C(CC2)[C@H]1[C@@](C)(CC1)[C@@H]2C[C@]1(C)O LKPVDGWWWXFWJJ-ROOJVTFQSA-N 0.000 description 1
- SKKKXWBZVMFJFJ-YSDXZOGCSA-N CC(CC1)([C@@H](CC2)C(CC3)[C@H]1C(C)(CC1)[C@@H]3C[C@]1(C)O)C2C(c1cc(C)c(C)cc1)=O Chemical compound CC(CC1)([C@@H](CC2)C(CC3)[C@H]1C(C)(CC1)[C@@H]3C[C@]1(C)O)C2C(c1cc(C)c(C)cc1)=O SKKKXWBZVMFJFJ-YSDXZOGCSA-N 0.000 description 1
- SEVLRZGBSQUYHK-PPGGWLFVSA-N CC(CC1)([C@@H](CC2)C(CC3)[C@H]1[C@@](C)(CC1)C3C[C@]1(C)O)[C@H]2C(c(cc1)ccc1OC(F)(F)F)=O Chemical compound CC(CC1)([C@@H](CC2)C(CC3)[C@H]1[C@@](C)(CC1)C3C[C@]1(C)O)[C@H]2C(c(cc1)ccc1OC(F)(F)F)=O SEVLRZGBSQUYHK-PPGGWLFVSA-N 0.000 description 1
- OYCAXWJZOXEPRE-SKCDODSBSA-N CC1C(C)=CC(C([C@@H](CC2)[C@@](C)(CC3)[C@@H]2C(CC2)[C@H]3[C@@](C)(CC3)[C@@H]2C[C@]3(C)O)=O)=CC1 Chemical compound CC1C(C)=CC(C([C@@H](CC2)[C@@](C)(CC3)[C@@H]2C(CC2)[C@H]3[C@@](C)(CC3)[C@@H]2C[C@]3(C)O)=O)=CC1 OYCAXWJZOXEPRE-SKCDODSBSA-N 0.000 description 1
- QUECWXYHZYXRNL-AKMKAEOHSA-N CCC(CC1)([C@](C)(CC2)C(C)(CC3)C2C(C2C(C4)C4C(N(C)C)=CC2)=O)[C@@]3(C)C(C)(CC2)[C@H]1C[C@]2(C)O Chemical compound CCC(CC1)([C@](C)(CC2)C(C)(CC3)C2C(C2C(C4)C4C(N(C)C)=CC2)=O)[C@@]3(C)C(C)(CC2)[C@H]1C[C@]2(C)O QUECWXYHZYXRNL-AKMKAEOHSA-N 0.000 description 1
- LBMMGQNKAKKYFQ-INLHBMBJSA-N CCC(CC[C@](C)(C1)[O]=C)(C(C)CC2)[C@@]1(C)CCC[C@H](CC1)[C@@]2(C)C1C(c(cc1)cc(C)c1F)=O Chemical compound CCC(CC[C@](C)(C1)[O]=C)(C(C)CC2)[C@@]1(C)CCC[C@H](CC1)[C@@]2(C)C1C(c(cc1)cc(C)c1F)=O LBMMGQNKAKKYFQ-INLHBMBJSA-N 0.000 description 1
- PSLHTBSZNHOGDF-JYQNWREZSA-N C[C@@H](CC1)C[C@@H](CC2)[C@H]1[C@@H](CC1)[C@@H]2[C@H](CC2)[C@@]1(C)[C@H]2C(c1ccc(C)cc1)=N Chemical compound C[C@@H](CC1)C[C@@H](CC2)[C@H]1[C@@H](CC1)[C@@H]2[C@H](CC2)[C@@]1(C)[C@H]2C(c1ccc(C)cc1)=N PSLHTBSZNHOGDF-JYQNWREZSA-N 0.000 description 1
- SHQUFCQNCSMJHQ-LAWOIKPDSA-N C[C@@H](CCC1(C)[C@@H]2C(CC3)CCC[C@H](C(c4ccc(C)c(F)c4)O)C(C)CC2)C[C@@]13N Chemical compound C[C@@H](CCC1(C)[C@@H]2C(CC3)CCC[C@H](C(c4ccc(C)c(F)c4)O)C(C)CC2)C[C@@]13N SHQUFCQNCSMJHQ-LAWOIKPDSA-N 0.000 description 1
- NJZLRUALCFJKFJ-SUSYSVFISA-N C[C@@](CC[C@@H](C1CC2)C(CC[C@](C)(C3)O)C23N)(C(CC2)C(c3ccccc3I)=C)[C@]12N Chemical compound C[C@@](CC[C@@H](C1CC2)C(CC[C@](C)(C3)O)C23N)(C(CC2)C(c3ccccc3I)=C)[C@]12N NJZLRUALCFJKFJ-SUSYSVFISA-N 0.000 description 1
- JDJYBSSMKXYWBA-ROEXDCMRSA-N C[C@H](CC1)[C@](C)(CC[C@@H](CCC2)[C@@H](CC3)[C@@H]2C[C@]3(C)O)[C@H]1C(c(cc1)ccc1OC)=O Chemical compound C[C@H](CC1)[C@](C)(CC[C@@H](CCC2)[C@@H](CC3)[C@@H]2C[C@]3(C)O)[C@H]1C(c(cc1)ccc1OC)=O JDJYBSSMKXYWBA-ROEXDCMRSA-N 0.000 description 1
- BOBXFKPVTXBFDX-XKKDOOBNSA-N C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1[C@@H]1[C@H]3CC(C)(C)CC1)[C@H]2C(c1cnc[nH]1)=[U] Chemical compound C[C@](CC1)([C@@H](CC2)C(CC3)[C@H]1[C@@H]1[C@H]3CC(C)(C)CC1)[C@H]2C(c1cnc[nH]1)=[U] BOBXFKPVTXBFDX-XKKDOOBNSA-N 0.000 description 1
- YDUKUYRDNOIQBA-LSBZSBGNSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@@H]3C[C@]1(C)O)[C@H]2C(c(cc1)ccc1Cl)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@@H]3C[C@]1(C)O)[C@H]2C(c(cc1)ccc1Cl)=O YDUKUYRDNOIQBA-LSBZSBGNSA-N 0.000 description 1
- UXTNTNONGLSRPS-RGYBDQPCSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@]1(C)O)[C@H]2C(c(cc1)cc(cc2)c1cc2OC)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@]1(C)O)[C@H]2C(c(cc1)cc(cc2)c1cc2OC)=O UXTNTNONGLSRPS-RGYBDQPCSA-N 0.000 description 1
- IOSGZVVLXFCLDP-SCNDPVEVSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@]1(C)O)[C@H]2C(c1cccc([I]=C)c1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@H]3C[C@]1(C)O)[C@H]2C(c1cccc([I]=C)c1)=O IOSGZVVLXFCLDP-SCNDPVEVSA-N 0.000 description 1
- LEOLRQXBZFHWNP-XIGAYJBWSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC[C@](C)(C1)O)[C@]31N)[C@H]2C(c1ccc(C)cc1)=C Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC[C@](C)(C1)O)[C@]31N)[C@H]2C(c1ccc(C)cc1)=C LEOLRQXBZFHWNP-XIGAYJBWSA-N 0.000 description 1
- SIUDUIXAPIRZAZ-BFNNADBGSA-N C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC[C@](C)(C1)[N+]([O-])=O)[C@]31N)[C@H]2C(c1c(C)cccc1)=O Chemical compound C[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC[C@](C)(C1)[N+]([O-])=O)[C@]31N)[C@H]2C(c1c(C)cccc1)=O SIUDUIXAPIRZAZ-BFNNADBGSA-N 0.000 description 1
- 208000028698 Cognitive impairment Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- DYAHQFWOVKZOOW-UHFFFAOYSA-N Sarin Chemical compound CC(C)OP(C)(F)=O DYAHQFWOVKZOOW-UHFFFAOYSA-N 0.000 description 1
- GRXKLBBBQUKJJZ-UHFFFAOYSA-N Soman Chemical compound CC(C)(C)C(C)OP(C)(F)=O GRXKLBBBQUKJJZ-UHFFFAOYSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- PJVJTCIRVMBVIA-JTQLQIEISA-N [dimethylamino(ethoxy)phosphoryl]formonitrile Chemical compound CCO[P@@](=O)(C#N)N(C)C PJVJTCIRVMBVIA-JTQLQIEISA-N 0.000 description 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 201000006517 essential tremor Diseases 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- 206010027175 memory impairment Diseases 0.000 description 1
- 230000002151 myoclonic effect Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 description 1
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021090965A JP7186259B2 (ja) | 2014-11-27 | 2021-05-31 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022189056A JP2023022187A (ja) | 2014-11-27 | 2022-11-28 | Ｃｎｓ障害を処置するための組成物および方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNPCT/CN2014/092369 | 2014-11-27 | ||
| CN2014092369 | 2014-11-27 | ||
| PCT/CN2015/095765 WO2016082789A1 (en) | 2014-11-27 | 2015-11-27 | Compositions and methods for treating cns disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021090965A Division JP7186259B2 (ja) | 2014-11-27 | 2021-05-31 | Ｃｎｓ障害を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017535586A JP2017535586A (ja) | 2017-11-30 |
| JP2017535586A5 true JP2017535586A5 (enrdf_load_stackoverflow) | 2019-01-10 |
| JP6893173B2 JP6893173B2 (ja) | 2021-06-23 |
Family
ID=56073637
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528154A Active JP6893173B2 (ja) | 2014-11-27 | 2015-11-27 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2021090965A Active JP7186259B2 (ja) | 2014-11-27 | 2021-05-31 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022189056A Pending JP2023022187A (ja) | 2014-11-27 | 2022-11-28 | Ｃｎｓ障害を処置するための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021090965A Active JP7186259B2 (ja) | 2014-11-27 | 2021-05-31 | Ｃｎｓ障害を処置するための組成物および方法 |
| JP2022189056A Pending JP2023022187A (ja) | 2014-11-27 | 2022-11-28 | Ｃｎｓ障害を処置するための組成物および方法 |
Country Status (16)
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3152410A1 (en) | 2011-10-14 | 2013-04-18 | Sage Therapeutics, Inc. | 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders |
| BR112015003747A2 (pt) | 2012-08-21 | 2017-07-04 | Sage Therapeutics Inc | métodos de tratamento de epilepsia ou estado de mal epiléptico |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| JP6239091B2 (ja) | 2013-04-17 | 2017-11-29 | セージ セラピューティクス， インコーポレイテッド | １９−ノル神経刺激性ステロイドおよびその使用方法 |
| IL310348A (en) | 2013-04-17 | 2024-03-01 | Sage Therapeutics Inc | 19- NOR C3, 3- dimomer C21- N- pyrazole Steroids and methods of using them |
| HRP20210610T1 (hr) | 2013-07-19 | 2021-05-28 | Sage Therapeutics, Inc. | Neuroaktivni steroidi, pripravci i njihove uporabe |
| CN105579043B (zh) | 2013-08-23 | 2021-09-14 | 萨奇治疗股份有限公司 | 神经活性类固醇、组合物和其用途 |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| CN118344423A (zh) | 2014-10-16 | 2024-07-16 | 萨奇治疗股份有限公司 | 靶向cns障碍的组合物和方法 |
| AU2015331597B2 (en) | 2014-10-16 | 2020-04-30 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| ES2793237T3 (es) * | 2014-11-27 | 2020-11-13 | Sage Therapeutics Inc | Composiciones y métodos para el tratamiento de trastornos del SNC |
| EP3250210B1 (en) | 2015-01-26 | 2020-12-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| DK3258939T3 (da) | 2015-02-20 | 2022-12-12 | Sage Therapeutics Inc | Neuroaktive steroider, sammensætninger og anvendelser heraf |
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| TWI855081B (zh) | 2019-05-24 | 2024-09-11 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
| AU2020284110A1 (en) | 2019-05-31 | 2021-11-25 | Sage Therapeutics, Inc. | Neuroactive steroids and compositions thereof |
| JP7670632B2 (ja) | 2019-06-27 | 2025-04-30 | セージ セラピューティクス， インコーポレイテッド | Ｃｎｓ障害を治療するための組成物及び方法 |
| TW202114696A (zh) | 2019-06-27 | 2021-04-16 | 美商賽吉醫療公司 | 用於治療cns病症之組合物及方法 |
| US20230303616A9 (en) | 2019-06-27 | 2023-09-28 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| KR20220112803A (ko) | 2019-12-05 | 2022-08-11 | 세이지 테라퓨틱스, 인크. | 19-nor c3,3-이치환된 c21-n-피라졸릴 스테로이드 및 그의 사용 방법 |
| US20240239835A9 (en) | 2020-03-18 | 2024-07-18 | Sage Therapeutics, Inc. | Neuroactive steroids and their methods of use |
| CN115551514A (zh) | 2020-03-25 | 2022-12-30 | 萨奇治疗股份有限公司 | 用于治疗呼吸系统病症的药物的用途 |
| WO2021262836A1 (en) | 2020-06-24 | 2021-12-30 | Sage Therapeutics, Inc. | 3.alpha.-hydroxy, 17.beta.-c(o)-n-aryl substituted neuroactive steroids and compositions thereof |
| JP2023537240A (ja) | 2020-07-20 | 2023-08-31 | セージ セラピューティクス， インコーポレイテッド | １９－ノルｃ３，３－二置換ｃ２１－ｎ－ピラゾリルステロイドの製剤及びその使用方法 |
| CA3202870A1 (en) | 2020-11-25 | 2022-06-02 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| WO2022165017A1 (en) | 2021-01-28 | 2022-08-04 | Sage Therapeutics, Inc. | Use of neuroactive steroids for treatment of sexual dysfunction |
| US20240148756A1 (en) | 2021-02-18 | 2024-05-09 | Sage Therapeutics, Inc. | Use of neuroactive steroid for treatment of sexual dysfunction |
| IL305858A (en) | 2021-03-17 | 2023-11-01 | Sage Therapeutics Inc | A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid for the treatment of major depressive disorder |
| AU2022258203A1 (en) | 2021-04-12 | 2023-10-26 | Sage Therapeutics, Inc. | Treatment of essential tremor |
| KR20240006026A (ko) | 2021-04-29 | 2024-01-12 | 세이지 테라퓨틱스, 인크. | 주요 우울 장애 및 산후 우울증을 치료하는 데 사용하기 위한 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드 |
| MX2023012728A (es) | 2021-04-29 | 2023-11-08 | Sage Therapeutics Inc | Esteroide neuroactivo para el tratamiento del trastorno depresivo mayor y la depresion posparto en una mujer lactante. |
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2015
- 2015-11-27 ES ES15862506T patent/ES2793237T3/es active Active
- 2015-11-27 DK DK15862506.1T patent/DK3224269T3/da active
- 2015-11-27 EP EP15862506.1A patent/EP3224269B1/en active Active
- 2015-11-27 HR HRP20200840TT patent/HRP20200840T1/hr unknown
- 2015-11-27 SM SM20200276T patent/SMT202000276T1/it unknown
- 2015-11-27 JP JP2017528154A patent/JP6893173B2/ja active Active
- 2015-11-27 RS RS20200610A patent/RS60343B1/sr unknown
- 2015-11-27 LT LTEP15862506.1T patent/LT3224269T/lt unknown
- 2015-11-27 SI SI201531219T patent/SI3224269T1/sl unknown
- 2015-11-27 PT PT158625061T patent/PT3224269T/pt unknown
- 2015-11-27 EP EP20159317.5A patent/EP3719029A1/en not_active Ceased
- 2015-11-27 ME MEP-2020-105A patent/ME03749B/me unknown
- 2015-11-27 PL PL15862506T patent/PL3224269T3/pl unknown
- 2015-11-27 US US15/531,313 patent/US10774108B2/en active Active
- 2015-11-27 HU HUE15862506A patent/HUE049014T2/hu unknown
- 2015-11-27 WO PCT/CN2015/095765 patent/WO2016082789A1/en active Application Filing
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2020
- 2020-02-25 US US16/800,053 patent/US20210017218A1/en not_active Abandoned
- 2020-05-26 CY CY20201100480T patent/CY1123200T1/el unknown
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2021
- 2021-05-31 JP JP2021090965A patent/JP7186259B2/ja active Active
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2022
- 2022-10-04 US US17/959,592 patent/US11945836B2/en active Active
- 2022-11-28 JP JP2022189056A patent/JP2023022187A/ja active Pending
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2024
- 2024-02-20 US US18/581,595 patent/US20250042934A1/en active Pending
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