JP2017534572A5 - - Google Patents
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- JP2017534572A5 JP2017534572A5 JP2017512313A JP2017512313A JP2017534572A5 JP 2017534572 A5 JP2017534572 A5 JP 2017534572A5 JP 2017512313 A JP2017512313 A JP 2017512313A JP 2017512313 A JP2017512313 A JP 2017512313A JP 2017534572 A5 JP2017534572 A5 JP 2017534572A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- optionally substituted
- group
- independently
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020097823A JP6918378B2 (ja) | 2014-09-05 | 2020-06-04 | ＣａＭＫＩＩ阻害剤及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046450P | 2014-09-05 | 2014-09-05 | |
| US62/046,450 | 2014-09-05 | ||
| PCT/US2015/048640 WO2016037106A1 (en) | 2014-09-05 | 2015-09-04 | CaMKII INHIBITORS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020097823A Division JP6918378B2 (ja) | 2014-09-05 | 2020-06-04 | ＣａＭＫＩＩ阻害剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534572A JP2017534572A (ja) | 2017-11-24 |
| JP2017534572A5 true JP2017534572A5 (https=) | 2018-10-11 |
| JP6782227B2 JP6782227B2 (ja) | 2020-11-11 |
Family
ID=54150675
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512313A Active JP6782227B2 (ja) | 2014-09-05 | 2015-09-04 | ＣａＭＫＩＩ阻害剤及びその使用 |
| JP2020097823A Expired - Fee Related JP6918378B2 (ja) | 2014-09-05 | 2020-06-04 | ＣａＭＫＩＩ阻害剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020097823A Expired - Fee Related JP6918378B2 (ja) | 2014-09-05 | 2020-06-04 | ＣａＭＫＩＩ阻害剤及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10759792B2 (https=) |
| EP (1) | EP3189052B1 (https=) |
| JP (2) | JP6782227B2 (https=) |
| CN (1) | CN107074856A (https=) |
| AU (2) | AU2015311730A1 (https=) |
| CA (1) | CA2960101C (https=) |
| WO (1) | WO2016037106A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR110252A1 (es) | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| WO2019049148A1 (en) * | 2017-09-10 | 2019-03-14 | Carmel Haifa University Economic Corporation Ltd. | METHOD OF TREATING DEPRESSION AND MAJOR DEPRESSIVE DISORDER |
| CN108218862B (zh) * | 2018-02-07 | 2020-06-23 | 贵州医科大学 | α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用 |
| KR20200140805A (ko) | 2018-02-21 | 2020-12-16 | 브리스톨-마이어스 스큅 컴퍼니 | Camk2d 안티센스 올리고뉴클레오티드 및 그의 용도 |
| CN108904532B (zh) * | 2018-08-20 | 2021-07-27 | 上海市第一人民医院 | 一种富勒烯C60纳米晶体联合CaMKII抑制剂的组合物的应用 |
| WO2020109191A1 (en) * | 2018-11-27 | 2020-06-04 | F. Hoffmann-La Roche Ag | Aryl compounds for the treatment and prophylaxis of bacterial infection |
| TW202229273A (zh) * | 2020-09-28 | 2022-08-01 | 美商卡都瑞恩醫藥有限責任公司 | 稠合雜芳基化合物及其作為CaMKII抑制劑之用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1913124A (en) * | 1932-01-02 | 1933-06-06 | American Sundries Co Inc | Vaporizer |
| US2690441A (en) * | 1953-06-11 | 1954-09-28 | Searle & Co | 3-carboline derivatives |
| GB1268773A (en) * | 1968-03-15 | 1972-03-29 | Glaxo Lab Ltd | NOVEL alpha-CARBOLINE DERIVATIVES, THE PREPARATION THEREOF AND COMPOSITIONS CONTAINING THE SAME |
| BE758991A (fr) * | 1969-11-18 | 1971-05-17 | Reeves Bros Inc | Procede de reticulation hydrodynamique d'une mousse de polyurethanne |
| PL80610B1 (https=) * | 1970-03-12 | 1975-08-30 | ||
| GB8600651D0 (en) * | 1986-01-11 | 1986-02-19 | Beecham Group Plc | Compounds |
| DE4435477A1 (de) | 1994-10-04 | 1996-04-11 | Bayer Ag | Cycloalkano-indol- und -azaindol-derivate |
| JP2001509808A (ja) | 1997-01-31 | 2001-07-24 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 多機能性カルシウム／カルモジュリン−依存性プロテインキナーゼの阻害による不整脈の処置 |
| US7320959B2 (en) | 2001-10-01 | 2008-01-22 | Vanderbilt University | Use of calmodulin kinase II inhibitors to treat myocardial dysfunction in structural heart disease |
| AU2003300522A1 (en) | 2002-12-27 | 2004-07-22 | Bayer Healthcare Ag | 4-phenyl-pyrimido (4,5-b) indole derivatives |
| US20060057639A1 (en) | 2004-06-16 | 2006-03-16 | Pitt Geoffrey S | CaMKII/calcium channel phosphorylation-related compositions and methods |
| FR2876377B1 (fr) * | 2004-10-11 | 2007-03-16 | Univ Claude Bernard Lyon | Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes |
| EP1815867A4 (en) | 2004-11-02 | 2010-06-09 | Dainippon Sumitomo Pharma Co | COMBINATION PREPARATION FOR THE TREATMENT OF AUTOIMMUNE DISEASE |
| DE602006014540D1 (en) * | 2005-05-16 | 2010-07-08 | Irm Llc | Pyrrolopyridinderivate als proteinkinaseinhibitoren |
| WO2006127587A1 (en) | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
| EP1896472A1 (de) * | 2005-06-09 | 2008-03-12 | Boehringer Ingelheim International GmbH | Alpha-carboline als cdk-1 inhibitoren |
| WO2007005831A2 (en) | 2005-07-01 | 2007-01-11 | Texas A & M University System | Zinc oxide polymer nanocomposites and methods of producing zinc oxide polymer nanocomposites |
| US20070208053A1 (en) | 2006-01-19 | 2007-09-06 | Arnold Lee D | Fused heterobicyclic kinase inhibitors |
| TW200908968A (en) | 2007-05-29 | 2009-03-01 | Sgx Pharmaceuticals Inc | Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators |
| US20110046378A1 (en) * | 2008-02-14 | 2011-02-24 | Siemens Medical Solutions Usa, Inc. | Novel Imaging Agents for Detecting Neurological Dysfunction |
| AU2009274023A1 (en) | 2008-07-23 | 2010-01-28 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| EP2323482A4 (en) | 2008-08-06 | 2011-08-17 | Merck & Co Inc | SUBSTITUTED DIHYDROISOCHINOLINONE AND ISOCHINOLINDION DERIVATIVES AS CALCIUM CHANNEL BLOCKERS |
| EP2161271A1 (en) | 2008-09-08 | 2010-03-10 | Università Degli Studi Di Milano - Bicocca | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl |
| AU2009308706C1 (en) | 2008-10-31 | 2016-01-21 | Medivation Technologies, Inc. | Pyrido (4,3-b) indoles containing rigid moieties |
| JP2012051804A (ja) * | 2008-12-26 | 2012-03-15 | Kyoto Univ | Ｅｇ５阻害剤 |
| US8440656B2 (en) | 2009-06-22 | 2013-05-14 | University Of Iowa Research Foundation | Methods of treating pulmonary diseases and disorders by modulating calcium/calmodulin dependent protein kinase II activity |
| US8685969B2 (en) | 2010-06-16 | 2014-04-01 | Bristol-Myers Squibb Company | Carboline carboxamide compounds useful as kinase inhibitors |
| EP2758376A4 (en) | 2011-09-19 | 2015-04-29 | Vitas Pharma Res Private Ltd | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF FATTY ACID BIOSYNTHESIS FOR BACTERIAL INFECTIONS |
| US9914730B2 (en) * | 2012-09-28 | 2018-03-13 | Cancer Research Technology Limited | Azaquinazoline inhibitors of Atypical protein Kinase C |
| AU2014225889B2 (en) | 2013-03-06 | 2018-12-06 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
-
2015
- 2015-09-04 WO PCT/US2015/048640 patent/WO2016037106A1/en not_active Ceased
- 2015-09-04 JP JP2017512313A patent/JP6782227B2/ja active Active
- 2015-09-04 AU AU2015311730A patent/AU2015311730A1/en not_active Abandoned
- 2015-09-04 US US15/506,501 patent/US10759792B2/en active Active
- 2015-09-04 CN CN201580058739.0A patent/CN107074856A/zh active Pending
- 2015-09-04 EP EP15766981.3A patent/EP3189052B1/en active Active
- 2015-09-04 CA CA2960101A patent/CA2960101C/en active Active
-
2020
- 2020-06-04 JP JP2020097823A patent/JP6918378B2/ja not_active Expired - Fee Related
- 2020-06-12 AU AU2020203927A patent/AU2020203927B9/en not_active Ceased
- 2020-08-24 US US17/000,644 patent/US11325908B2/en active Active
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