JP2017533264A5 - - Google Patents
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- Publication number
- JP2017533264A5 JP2017533264A5 JP2017541143A JP2017541143A JP2017533264A5 JP 2017533264 A5 JP2017533264 A5 JP 2017533264A5 JP 2017541143 A JP2017541143 A JP 2017541143A JP 2017541143 A JP2017541143 A JP 2017541143A JP 2017533264 A5 JP2017533264 A5 JP 2017533264A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- mixture
- poloxamer
- kosendangusa
- propylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 20
- 239000000284 extract Substances 0.000 claims 14
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 229920001983 poloxamer Polymers 0.000 claims 10
- 229960000502 poloxamer Drugs 0.000 claims 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 239000003826 tablet Substances 0.000 claims 7
- 239000007788 liquid Substances 0.000 claims 6
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 229940068918 polyethylene glycol 400 Drugs 0.000 claims 5
- 239000008513 turmeric extract Substances 0.000 claims 5
- 229940052016 turmeric extract Drugs 0.000 claims 5
- 235000020240 turmeric extract Nutrition 0.000 claims 5
- 239000012153 distilled water Substances 0.000 claims 4
- 238000010438 heat treatment Methods 0.000 claims 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- 238000002156 mixing Methods 0.000 claims 4
- 230000003232 mucoadhesive effect Effects 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 3
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 3
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims 3
- 238000010907 mechanical stirring Methods 0.000 claims 3
- 239000012071 phase Substances 0.000 claims 3
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims 3
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims 3
- 229940001584 sodium metabisulfite Drugs 0.000 claims 3
- 235000010262 sodium metabisulphite Nutrition 0.000 claims 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- 239000004264 Petrolatum Substances 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 2
- 229960000541 cetyl alcohol Drugs 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000005469 granulation Methods 0.000 claims 2
- 230000003179 granulation Effects 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- 229940066842 petrolatum Drugs 0.000 claims 2
- 235000019271 petrolatum Nutrition 0.000 claims 2
- 239000000419 plant extract Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000011885 synergistic combination Substances 0.000 claims 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 2
- 229930153442 Curcuminoid Natural products 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 239000006286 aqueous extract Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 229940075507 glyceryl monostearate Drugs 0.000 claims 1
- 229940075529 glyceryl stearate Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 1
- 125000006353 oxyethylene group Chemical group 0.000 claims 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
- 229920001992 poloxamer 407 Polymers 0.000 claims 1
- 229940044476 poloxamer 407 Drugs 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000011343 solid material Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 229910001220 stainless steel Inorganic materials 0.000 claims 1
- 239000010935 stainless steel Substances 0.000 claims 1
- 208000003265 stomatitis Diseases 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/BR2014/050002 WO2016065442A1 (pt) | 2014-10-27 | 2014-10-27 | Composições farmacêuticas antiinflamatórias, proliferativas, protetoras e mucoadesivas, solúveis e estáveis; seu uso no tratamento dos quadros de mucosite e processo de obtenção; composição farmacêutica de base para o preparo das composições farmacêuticas e seu processo de obtenção |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533264A JP2017533264A (ja) | 2017-11-09 |
| JP2017533264A5 true JP2017533264A5 (cg-RX-API-DMAC7.html) | 2017-12-21 |
| JP7020915B2 JP7020915B2 (ja) | 2022-02-16 |
Family
ID=55856293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541143A Active JP7020915B2 (ja) | 2014-10-27 | 2014-10-27 | 抗炎症性、増殖性、保護性及び粘膜付着性の、可溶性且つ安定な医薬組成物、粘膜部位の状態を治療するためのその使用及び取得方法、並びに医薬組成物の調製のための基本医薬組成物及びその取得方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11007244B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3213760A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7020915B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2966060A1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2017114569A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016065442A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019203813A1 (en) * | 2018-04-18 | 2019-10-24 | Muhammed Majeed | Compositions containing tetrahydrocurcuminoids for improvement of oral health and hygiene |
| CN111358927B (zh) * | 2020-04-30 | 2021-09-07 | 深圳市宝安中医院（集团） | 蒲姜药物组合物及其应用 |
| CN112773887B (zh) * | 2021-01-06 | 2023-05-23 | 温州医科大学 | 一种用于结肠黏膜修复的温敏凝胶 |
| CN115919816B (zh) * | 2022-09-27 | 2024-04-09 | 四川大学 | 姜黄素-四面体框架核酸载药系统在制备预防或治疗放射性口腔黏膜炎的药物中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07330582A (ja) * | 1994-01-31 | 1995-12-19 | Takeda Chem Ind Ltd | 直腸投与用組成物 |
| KR100419132B1 (ko) * | 2000-12-29 | 2004-02-18 | 조성근 | 위·장 점막 부착성과 증식성, 내산성, 내담즙성 및헬리코박터 파일로리, 대장균 0157:ｈ7에 대한 항균성이우수한 락토바실러스 파라카제이 서브스패시즈 파라카제이ｃｓｋ 01 |
| EP1997478B1 (en) * | 2001-02-15 | 2013-09-04 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
| EP2346520B1 (en) * | 2008-11-17 | 2014-11-26 | Laila Pharmaceuticals Pvt. Ltd. | Curcuminoids and its metabolites for the application in ocular diseases |
| AT509777B1 (de) * | 2010-04-30 | 2012-03-15 | Orphanidis Pharma Res Gmbh | Adhesive retardformulierungen zur lokalen verabreichung von curcumin |
-
2014
- 2014-10-27 US US15/522,763 patent/US11007244B2/en active Active
- 2014-10-27 WO PCT/BR2014/050002 patent/WO2016065442A1/pt not_active Ceased
- 2014-10-27 EP EP14905057.7A patent/EP3213760A4/en not_active Withdrawn
- 2014-10-27 JP JP2017541143A patent/JP7020915B2/ja active Active
- 2014-10-27 CA CA2966060A patent/CA2966060A1/en not_active Abandoned
- 2014-10-27 RU RU2017114569A patent/RU2017114569A/ru not_active Application Discontinuation
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