JP2017532037A5 - - Google Patents

Download PDF

Info

Publication number
JP2017532037A5
JP2017532037A5 JP2017518907A JP2017518907A JP2017532037A5 JP 2017532037 A5 JP2017532037 A5 JP 2017532037A5 JP 2017518907 A JP2017518907 A JP 2017518907A JP 2017518907 A JP2017518907 A JP 2017518907A JP 2017532037 A5 JP2017532037 A5 JP 2017532037A5
Authority
JP
Japan
Prior art keywords
fragment
seq
antibody
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017518907A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017532037A (ja
JP6794348B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/054490 external-priority patent/WO2016057667A1/en
Publication of JP2017532037A publication Critical patent/JP2017532037A/ja
Publication of JP2017532037A5 publication Critical patent/JP2017532037A5/ja
Application granted granted Critical
Publication of JP6794348B2 publication Critical patent/JP6794348B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017518907A 2014-10-10 2015-10-07 ヒト化抗ox40抗体及びその使用 Active JP6794348B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462062431P 2014-10-10 2014-10-10
US62/062,431 2014-10-10
PCT/US2015/054490 WO2016057667A1 (en) 2014-10-10 2015-10-07 Humanized anti-ox40 antibodies and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020187650A Division JP2021036887A (ja) 2014-10-10 2020-11-11 ヒト化抗ox40抗体及びその使用

Publications (3)

Publication Number Publication Date
JP2017532037A JP2017532037A (ja) 2017-11-02
JP2017532037A5 true JP2017532037A5 (Direct) 2018-11-15
JP6794348B2 JP6794348B2 (ja) 2020-12-09

Family

ID=55130798

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017518907A Active JP6794348B2 (ja) 2014-10-10 2015-10-07 ヒト化抗ox40抗体及びその使用
JP2020187650A Withdrawn JP2021036887A (ja) 2014-10-10 2020-11-11 ヒト化抗ox40抗体及びその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020187650A Withdrawn JP2021036887A (ja) 2014-10-10 2020-11-11 ヒト化抗ox40抗体及びその使用

Country Status (19)

Country Link
US (3) US9738723B2 (Direct)
EP (1) EP3204422B1 (Direct)
JP (2) JP6794348B2 (Direct)
KR (1) KR20170064550A (Direct)
CN (1) CN107074953A (Direct)
AR (1) AR102239A1 (Direct)
AU (1) AU2015328090A1 (Direct)
BR (1) BR112017007170A2 (Direct)
CA (1) CA2963798A1 (Direct)
CL (1) CL2017000885A1 (Direct)
CO (1) CO2017004516A2 (Direct)
ES (1) ES2914177T3 (Direct)
GB (1) GB2536324A (Direct)
IL (1) IL251537A0 (Direct)
MX (1) MX2017004715A (Direct)
RU (1) RU2709742C2 (Direct)
SG (1) SG11201702826XA (Direct)
TW (1) TW201619200A (Direct)
WO (1) WO2016057667A1 (Direct)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2976361T3 (en) 2013-03-18 2018-10-01 Biocerox Prod Bv HUMANIZED ANTI-CD134- (0X40) ANTIBODIES AND APPLICATIONS THEREOF
JP2017501167A (ja) * 2013-12-17 2017-01-12 ジェネンテック, インコーポレイテッド Ox40結合アゴニスト及びpd−1軸結合アンタゴニストを含む併用療法
CA2943834A1 (en) 2014-03-31 2015-10-08 Genentech, Inc. Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
SMT201900702T1 (it) * 2015-01-08 2020-01-14 Genmab As Agenti agonistici leganti il recettore del tnf
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
EA201792451A1 (ru) 2015-05-07 2018-05-31 Агенус Инк. Антитела к ox40 и способы их применения
US20160347848A1 (en) * 2015-05-28 2016-12-01 Medimmune Limited Therapeutic combinations and methods for treating neoplasia
WO2016196228A1 (en) 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Antibodies against ox40 and uses thereof
MX2018003820A (es) 2015-10-02 2018-12-10 F Hoffmann ­La Roche Ag Anticuerpos biespecificos especificos para un receptor de tnf coestimulador.
JP6771551B2 (ja) 2015-10-15 2020-10-21 ディンフー バイオターゲット カンパニー リミテッド 抗ox40抗体及びその応用
IL299072A (en) 2015-12-02 2023-02-01 Memorial Sloan Kettering Cancer Center Antibodies and methods for using them
IL321475A (en) 2016-05-06 2025-08-01 Medimmune Llc Bispecific binding proteins and their uses
ES3010640T3 (en) 2016-06-20 2025-04-04 Invox Pharma Ltd Lag-3 binding members
BR112018076281A2 (pt) 2016-06-20 2019-03-26 Kymab Limited imunocitocina, uso de uma imunocitocina, método, composição farmacêutica, método para tratar uma doença proliferativa em um animal, ácido nucleico, vetor, hospedeiro e anticorpo ou fragmento do mesmo
GB201612520D0 (en) 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules
MX2019000796A (es) * 2016-07-20 2019-06-03 Igm Biosciences Inc Moleculas multimericas de union a ox40 y usos de las mismas.
CN109963871A (zh) 2016-08-05 2019-07-02 豪夫迈·罗氏有限公司 具有激动活性的多价及多表位抗体以及使用方法
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
US10556962B2 (en) 2016-12-15 2020-02-11 Abbvie Biotherapeutics Inc. Anti-OX40 antibodies and their uses
AU2017384528A1 (en) 2016-12-19 2019-07-04 Ichnos Sciences SA Novel TNFR agonists and uses thereof
WO2018178055A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
AU2018253950A1 (en) 2017-04-20 2019-09-19 Adc Therapeutics Sa Combination therapy with an anti-CD25 antibody-drug conjugate
MX2019012464A (es) 2017-04-20 2019-12-11 Adc Therapeutics Sa Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl.
KR20200074214A (ko) * 2017-11-01 2020-06-24 브리스톨-마이어스 스큅 컴퍼니 암을 치료하는데 사용하기 위한 면역자극 효능작용 항체
AU2017440393B2 (en) * 2017-11-24 2025-02-20 Eucure (Beijing) Biopharma Co., Ltd Anti-OX40 antibodies and uses thereof
KR102452246B1 (ko) 2017-12-29 2022-10-12 에이피 바이오사이언시스, 아이엔씨. 암 치료법을 위한 면역 체크포인트 조절을 갖는 단일특이성 및 이중특이성 단백질
CN108218990B (zh) 2017-12-29 2021-03-02 南京优迈生物科技有限公司 分离的抗体或其抗原结合片段及其在肿瘤治疗中的应用
CN111393529B (zh) * 2018-01-29 2022-02-22 康源博创生物科技(北京)有限公司 与ox40l非竞争结合的抗ox40抗体
CA3093407A1 (en) 2018-03-23 2019-09-26 Bristol-Myers Squibb Company Antibodies against mica and/or micb and uses thereof
WO2019178852A1 (zh) * 2018-03-23 2019-09-26 苏州丁孚靶点生物技术有限公司 Ox40抗原多肽及其用途
CN120943884A (zh) 2018-03-27 2025-11-14 百时美施贵宝公司 使用紫外线信号实时监测滴度
AU2019264712A1 (en) 2018-05-11 2021-01-07 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against OX40, method for preparing same, and use thereof
EP3797123A4 (en) 2018-05-23 2022-03-02 BeiGene, Ltd. ANTI-OX40 ANTIBODIES AND METHODS OF USE
MX2020012418A (es) 2018-05-23 2021-04-28 Adc Therapeutics Sa Adyuvante molecular.
GB201811408D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd CD137 Binding Molecules
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
SG11202100172XA (en) 2018-07-12 2021-02-25 F Star Beta Ltd Antibody molecules that bind cd137 and ox40
GB201811403D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Antibody molecules
CN112423845B (zh) 2018-07-12 2024-07-30 F-星治疗有限公司 结合pd-l1和cd137的抗体分子
GB201811415D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-Mesothelin Anti bodies
GB201811450D0 (en) 2018-07-12 2018-08-29 F Star Delta Ltd Mesothelin and CD137 binding molecules
GB201811404D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd Anti-CD137 Antibodies
WO2020014583A1 (en) 2018-07-13 2020-01-16 Bristol-Myers Squibb Company Ox-40 agonist, pd-1 pathway inhibitor and ctla-4 inhibitor combination for use in a mehtod of treating a cancer or a solid tumor
CN111040034B (zh) * 2018-10-12 2022-08-30 广东旋玉健康生物科技有限公司 一种抗人cd358的单克隆抗体及其用途
TW202028222A (zh) 2018-11-14 2020-08-01 美商Ionis製藥公司 Foxp3表現之調節劑
EP3889180A4 (en) * 2018-11-26 2023-01-04 Nanjing GenScript Biotech Co., Ltd. ANTI-OX40 HUMANIZED MONOCLONAL ANTIBODY, METHOD FOR PREPARATION AND USE
WO2020119789A1 (en) * 2018-12-14 2020-06-18 Wuxi Biologics (Shanghai) Co., Ltd. Fully human antibodies against ox40, method for preparing the same, and use thereof
US12195545B2 (en) 2018-12-25 2025-01-14 Hanx Biopharmaceutics, Inc Anti-OX40 monoclonal antibody and application thereof
US10442866B1 (en) * 2019-01-23 2019-10-15 Beijing Mabworks Biotech Co. Ltd Antibodies binding OX40 and uses thereof
US20220135619A1 (en) 2019-02-24 2022-05-05 Bristol-Myers Squibb Company Methods of isolating a protein
WO2020176771A1 (en) 2019-02-27 2020-09-03 Ionis Pharmaceuticals, Inc. Modulators of malat1 expression
EP3946449A4 (en) * 2019-03-25 2022-11-09 Ohio State Innovation Foundation COMBINED IMMUNOREGULATION AND ASSOCIATED USES
KR20220012292A (ko) 2019-05-23 2022-02-03 브리스톨-마이어스 스큅 컴퍼니 세포 배양 배지를 모니터링하는 방법
CN114174538A (zh) 2019-05-30 2022-03-11 百时美施贵宝公司 适合于免疫肿瘤学疗法的多肿瘤基因特征
CN114127315A (zh) 2019-05-30 2022-03-01 百时美施贵宝公司 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
MX2022006147A (es) * 2019-11-21 2022-06-17 Beigene Ltd Metodos de tratamiento del cancer utilizando anticuerpos anti-ox40 en combinacion con anticuerpos anti-pd1 o anti-pdl1.
JP2023503230A (ja) * 2019-11-21 2023-01-27 ベイジーン リミテッド Pi3キナーゼデルタ阻害剤との組合せで抗ox40抗体を用いる癌治療の方法
US20230002500A1 (en) * 2019-11-21 2023-01-05 Beigene, Ltd. Methods of cancer treatment using anti-ox40 antibodies in combination with anti-tigit antibodies
JP2023503031A (ja) * 2019-11-21 2023-01-26 ベイジーン(ベイジン)カンパニー リミテッド 化学療法剤との組合せでの抗ox40抗体による癌治療の方法
KR20220103105A (ko) * 2019-11-21 2022-07-21 베이진 엘티디 항-tim3 항체와 병용하여 항-ox40 항체를 사용한 암 치료 방법
GB201917254D0 (en) 2019-11-27 2020-01-08 Adc Therapeutics Sa Combination therapy
WO2021111636A1 (ja) * 2019-12-06 2021-06-10 大塚製薬株式会社 抗gdf15抗体
JOP20220151A1 (ar) 2019-12-17 2023-01-30 Amgen Inc ناهض مستقبل إنترلوكين -2 / tnf المزدوج للاستخدام في العلاج
WO2021190431A1 (zh) 2020-03-23 2021-09-30 百奥泰生物制药股份有限公司 一种免疫细胞激活剂的开发及应用
KR20230015328A (ko) * 2020-04-17 2023-01-31 허치슨 메디파르마 리미티드 항-ox40 항체 및 이의 용도
WO2021228836A1 (en) 2020-05-13 2021-11-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Recombinant proteins with ox40 activating properties
MX2023002326A (es) 2020-08-31 2023-03-21 Bristol Myers Squibb Co Firma de localizacion celular e inmunoterapia.
CN116406369A (zh) 2020-10-05 2023-07-07 百时美施贵宝公司 用于浓缩蛋白质的方法
CN114457022A (zh) * 2020-10-30 2022-05-10 未来智人再生医学研究院(广州)有限公司 一种表达ox40激活型抗体的多能干细胞及其衍生物与应用
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
MX2023007650A (es) 2020-12-28 2023-09-11 Bristol Myers Squibb Co Metodos de tratamiento de tumores.
HRP20250628T1 (hr) 2020-12-28 2025-07-18 Bristol-Myers Squibb Company Mješavine antitijela i postupci njihove upotrebe
GB202102396D0 (en) 2021-02-19 2021-04-07 Adc Therapeutics Sa Molecular adjuvant
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
WO2023275616A1 (en) * 2021-06-29 2023-01-05 Hifibio (Hk) Limited Anti-ox40 monoclonal antibody and methods of use thereof
EP4448578A4 (en) 2021-12-17 2026-02-18 Shanghai Henlius Biotech Inc ANTI-OX40 ANTIBODIES, MULTI-SPECIFIC ANTIBODIES AND METHODS OF USE
WO2023109901A1 (en) 2021-12-17 2023-06-22 Shanghai Henlius Biotech, Inc. Anti-ox40 antibodies and methods of use
WO2023152116A1 (en) 2022-02-08 2023-08-17 Hookipa Biotech Gmbh Combination therapy with arenavirus particles and immune checkpoint modulators or cytokines
JP2025509274A (ja) 2022-03-09 2025-04-11 ブリストル-マイヤーズ スクイブ カンパニー 治療用タンパク質の一過性発現
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
CN114591988B (zh) * 2022-03-30 2023-01-13 北京贝来生物科技有限公司 一种激活肿瘤免疫的基因修饰干细胞制备方法
EP4531916A1 (en) 2022-06-02 2025-04-09 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CN114966061B (zh) * 2022-07-28 2022-10-21 中国食品药品检定研究院 一种抗ox40抗体的生物活性检测方法
EP4583999A1 (en) 2022-09-09 2025-07-16 Bristol-Myers Squibb Company Methods of separating chelator
WO2024196952A1 (en) 2023-03-20 2024-09-26 Bristol-Myers Squibb Company Tumor subtype assessment for cancer therapy
WO2025038763A1 (en) 2023-08-15 2025-02-20 Bristol-Myers Squibb Company Ceramic hydroxyapatite chromatography flow through method
US20250215087A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg depleting agent

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681718A (en) 1986-03-14 1997-10-28 Celltech Limited Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof
US5457035A (en) 1993-07-23 1995-10-10 Immunex Corporation Cytokine which is a ligand for OX40
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US6312700B1 (en) 1998-02-24 2001-11-06 Andrew D. Weinberg Method for enhancing an antigen specific immune response with OX-40L
EP1218408A4 (en) * 1999-09-24 2003-02-26 Human Genome Sciences Inc 32 HUMAN, SECRETED PROTEINS
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
US20080187954A1 (en) 2004-03-10 2008-08-07 Lonza Ltd. Method For Producing Antibodies
CA2581208A1 (en) 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
DK1877090T3 (da) 2005-05-06 2014-04-14 Providence Health System Trimert ox40-immunoglobulin-fusionsprotein og fremgangsmåder til anvendelse heraf
TWI461436B (zh) * 2005-11-25 2014-11-21 Kyowa Hakko Kirin Co Ltd 人類cd134(ox40)之人類單株抗體及其製造及使用方法
MY150756A (en) * 2006-08-21 2014-02-28 Hoffmann La Roche Tumor theraphy with an anti-vegf antibody
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
AU2008219666A1 (en) * 2007-02-27 2008-09-04 Genentech, Inc. Antagonist OX40 antibodies and their use in the treatment of inflammatory and autoimmune diseases
DK2242771T3 (da) * 2007-12-14 2013-08-26 Pfizer Bindingsmolekyler til den humane ox40-receptor
WO2009092014A1 (en) 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of antibodies and antibody fragments by apatite chromatography
MX2010008578A (es) 2008-02-08 2010-11-10 Medimmune Llc Anticuerpos anti-receptor 1 de interferon alfa con afinidad reducida al ligando fc.
SG2014014708A (en) * 2009-02-17 2014-05-29 Ucb Pharma Sa Antibody molecules having specificity for human ox40
WO2013028231A1 (en) 2011-08-23 2013-02-28 Board Of Regents, The University Of Texas System Anti-ox40 antibodies and methods of using the same
DK3604339T3 (da) * 2011-01-14 2021-04-12 Univ California Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme
CA3158257A1 (en) * 2011-07-11 2013-01-17 Ichnos Sciences SA Antibodies that bind to ox40 and their uses
GB201116092D0 (en) 2011-09-16 2011-11-02 Bioceros B V Antibodies and uses thereof
US9828432B2 (en) 2012-02-06 2017-11-28 Providence Health & Services—Oregon Cancer treatment and monitoring methods using OX40 agonists
HK1205691A1 (en) * 2012-03-02 2015-12-24 Providence Health & Services - Oregon Dual ox40 agonist/il-2 cancer therapy methods
US9409977B2 (en) * 2013-03-12 2016-08-09 Decimmune Therapeutics, Inc. Humanized, anti-N2 antibodies
DK2976361T3 (en) * 2013-03-18 2018-10-01 Biocerox Prod Bv HUMANIZED ANTI-CD134- (0X40) ANTIBODIES AND APPLICATIONS THEREOF

Similar Documents

Publication Publication Date Title
JP2017532037A5 (Direct)
RU2017115662A (ru) Гуманизированные антитела к ox40 и способы их применения
KR102503084B1 (ko) 항-ctla4 및 항-pd-1 이작용성 항체, 이의 약제학적 조성물 및 이의 용도
KR102469286B1 (ko) 항-pd1 단일클론 항체, 이의 약제학적 조성물 및 이의 용도
JP6976322B2 (ja) 新規抗ctla4抗体
KR102068600B1 (ko) Pdl-1 항체, 그 약학적 조성물 및 그 용도
JP2022160404A (ja) ヒトil-4受容体に対する高親和性ヒト抗体
AU2014238546C1 (en) Humanized anti-CD134 (OX40) antibodies and uses thereof
JP2020520665A5 (Direct)
WO2016191643A4 (en) Tigit-binding agents and uses thereof
CN110669135B (zh) 一种双特异性抗体及其用途
KR20190117493A (ko) 항 pd-1 항체 및 그의 용도
WO2018106529A1 (en) Anti-tim-3 antibodies for combination with anti-pd-l1 antibodies
EP3892634A1 (en) Anti-cd40 antibody, antigen binding fragment and pharmaceutical use thereof
EP3668898A1 (en) Humanized antibodies for cd3
IL254223B1 (en) CD20 binding compounds and their uses
CN110003338B (zh) 抗ox40抗体及其应用
HRP20210393T1 (hr) Anti-tfr antitijela i njihova uporaba u liječenju proliferativnih i upalnih poremećaja
RU2010107175A (ru) Антитела человека к cd20 человека и способ их использования
HRP20221226T1 (hr) Protutijela protiv pd-1 i postupci njihove upotrebe
CN104903352A (zh) 多价结合蛋白组合物
CN111183159A (zh) 靶向cd137的抗体及其使用方法
IL272770B2 (en) Agonistic cd40 antibodies
TW202313682A (zh) 抗icos抗體之用途
CN116194471A (zh) 抗pd-1抗体和融合蛋白