JP2017530356A - 心血管系のリスクイベントの予測及びその使用 - Google Patents

心血管系のリスクイベントの予測及びその使用 Download PDF

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JP2017530356A
JP2017530356A JP2017516046A JP2017516046A JP2017530356A JP 2017530356 A JP2017530356 A JP 2017530356A JP 2017516046 A JP2017516046 A JP 2017516046A JP 2017516046 A JP2017516046 A JP 2017516046A JP 2017530356 A JP2017530356 A JP 2017530356A
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risk
biomarker
event
gdf11
individual
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JP2017530356A5 (enExample
Inventor
デイヴィッド スターリング
デイヴィッド スターリング
シンタロウ カトウ
シンタロウ カトウ
エドワード エヌ． ブロディ
エドワード エヌ． ブロディ
スティーヴン エー． ウィリアムズ
スティーヴン エー． ウィリアムズ
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Somalogic Inc
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Somalogic Inc
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Publication of JP2017530356A publication Critical patent/JP2017530356A/ja
Publication of JP2017530356A5 publication Critical patent/JP2017530356A5/ja
Priority to JP2019140401A priority Critical patent/JP6956762B2/ja
Priority to JP2021163792A priority patent/JP7270696B2/ja
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4712—Muscle proteins, e.g. myosin, actin, protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/515—Angiogenesic factors; Angiogenin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/52—Assays involving cytokines
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/521—Chemokines
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
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    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
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  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Business, Economics & Management (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Bioethics (AREA)
  • Computer Vision & Pattern Recognition (AREA)
JP2017516046A 2014-09-26 2014-11-03 心血管系のリスクイベントの予測及びその使用 Pending JP2017530356A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2019140401A JP6956762B2 (ja) 2014-09-26 2019-07-31 心血管系のリスクイベントの予測及びその使用
JP2021163792A JP7270696B2 (ja) 2014-09-26 2021-10-05 心血管系のリスクイベントの予測及びその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462055984P 2014-09-26 2014-09-26
US62/055,984 2014-09-26
PCT/US2014/063714 WO2016048388A1 (en) 2014-09-26 2014-11-03 Cardiovascular risk event prediction and uses thereof

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JP2019140401A Division JP6956762B2 (ja) 2014-09-26 2019-07-31 心血管系のリスクイベントの予測及びその使用

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JP2017530356A5 JP2017530356A5 (enExample) 2017-12-07

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JP2017516046A Pending JP2017530356A (ja) 2014-09-26 2014-11-03 心血管系のリスクイベントの予測及びその使用
JP2019140401A Active JP6956762B2 (ja) 2014-09-26 2019-07-31 心血管系のリスクイベントの予測及びその使用
JP2021163792A Active JP7270696B2 (ja) 2014-09-26 2021-10-05 心血管系のリスクイベントの予測及びその使用

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JP2021163792A Active JP7270696B2 (ja) 2014-09-26 2021-10-05 心血管系のリスクイベントの予測及びその使用

Country Status (9)

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US (2) US10670611B2 (enExample)
EP (1) EP3198023B1 (enExample)
JP (3) JP2017530356A (enExample)
KR (1) KR102328327B1 (enExample)
AU (1) AU2014407088B2 (enExample)
BR (1) BR112017005730B1 (enExample)
CA (2) CA3103560C (enExample)
ES (1) ES2792227T3 (enExample)
WO (1) WO2016048388A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021507216A (ja) * 2017-12-13 2021-02-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 脳卒中の予測のための循環アンジオポエチン−２（Ａｎｇ−２）およびインスリン様増殖因子結合タンパク質７（ＩＧＦＢＰ７）
JP2022546515A (ja) * 2019-09-03 2022-11-04 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管リスク／イベントの予測及びその使用
JP2023502984A (ja) * 2019-11-15 2023-01-26 ゲイシンガー クリニック ヘルスケア集団の管理に対する機械学習手法のためのシステムおよび方法
JP2023546563A (ja) * 2020-10-20 2023-11-06 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管イベントリスクの予測

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7844609B2 (en) 2007-03-16 2010-11-30 Expanse Networks, Inc. Attribute combination discovery
US8108406B2 (en) 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
EP2370929A4 (en) 2008-12-31 2016-11-23 23Andme Inc SEARCH FOR RELATED IN A DATABASE
US20170055935A1 (en) * 2014-04-11 2017-03-02 Hitachi, Ltd. Medical image scanning apparatus and medical image scanning method
CN118522390A (zh) * 2016-04-01 2024-08-20 20/20基因系统股份有限公司 帮助区别良性和恶性放射线照相明显肺结节的方法和组合物
WO2017214684A1 (en) * 2016-06-17 2017-12-21 Adelaide Research & Innovation Pty Ltd Methods and products for identifying conditions associated with cardiac fibrotic remodelling
KR102322258B1 (ko) 2017-05-19 2021-11-04 현대자동차 주식회사 마이크로폰 및 그 제조 방법
US11079394B2 (en) * 2017-07-25 2021-08-03 Vanderbilt University Detection of angiopoietin-2 and thrombospondin-2 in connection with diagnosing acute heart failure
WO2019074491A1 (en) * 2017-10-10 2019-04-18 Flagship Biosciences, Inc. PATIENT STRATIFICATION METHOD USING IMAGE ANALYSIS PARAMETER DELIVERY FUNCTIONS
US10825564B1 (en) * 2017-12-11 2020-11-03 State Farm Mutual Automobile Insurance Company Biometric characteristic application using audio/video analysis
US10503970B1 (en) 2017-12-11 2019-12-10 State Farm Mutual Automobile Insurance Company Method and system for identifying biometric characteristics using machine learning techniques
US11317872B2 (en) * 2017-12-15 2022-05-03 Mayo Foundation For Medical Education And Research Predicting transient ischemic events using ECG data
US20190295727A1 (en) * 2018-03-23 2019-09-26 American Heart Association, Inc. System and Method for Assessing Heart Health and Communicating the Assessment to a Patient
TWI809247B (zh) * 2019-02-08 2023-07-21 日商日本電氣股份有限公司 人類t細胞白血病病毒1型（htlv-1）相關疾病的診斷方法
TWI741915B (zh) * 2019-03-06 2021-10-01 國立清華大學 檢測心血管疾病的檢驗套組及心血管疾病相關生物標記的濃度檢測方法
TWI716827B (zh) * 2019-03-06 2021-01-21 國立清華大學 檢測心血管疾病的檢驗套組及心血管疾病相關生物標記的濃度檢測方法
TWI741914B (zh) * 2019-03-06 2021-10-01 國立清華大學 檢測心血管疾病的檢驗套組及心血管疾病相關生物標記的濃度檢測方法
CN110068676A (zh) * 2019-03-22 2019-07-30 同济大学 分泌蛋白Serpin A3在预测心肌损伤诊断试剂中的应用
JP7215682B2 (ja) * 2019-09-09 2023-01-31 ａｉｗｅｌｌ株式会社 情報処理システムおよびプログラム
CN110838339B (zh) * 2019-09-23 2023-05-05 广东工业大学 邻苯二甲酸酯对斑马鱼毒性效应的预测方法、设备及介质
JP7597034B2 (ja) * 2019-10-10 2024-12-10 ソニーグループ株式会社 表示制御装置、表示制御方法、及び、プログラム
US10902955B1 (en) * 2020-05-01 2021-01-26 Georgetown University Detecting COVID-19 using surrogates
WO2021243166A2 (en) * 2020-05-28 2021-12-02 The Regents Of The University Of Michigan Deterimining risk of spontaneous coronary artery dissection and myocardial infarction and systems and methods of use thereof
US11416776B2 (en) * 2020-08-24 2022-08-16 Kpn Innovations, Llc. Method of and system for identifying and enumerating cross-body degradations
CN117099000A (zh) * 2021-03-08 2023-11-21 赛诺菲 心血管疾病
WO2023086746A1 (en) * 2021-11-11 2023-05-19 Beckman Coulter, Inc. Assessment of risk for major adverse cardiac event
CN114445445B (zh) * 2022-04-08 2022-07-01 广东欧谱曼迪科技有限公司 Ct图像的动脉分割方法、装置、电子设备及存储介质
CN117594131B (zh) * 2024-01-17 2024-04-16 北京市心肺血管疾病研究所 用于鉴别或辅助鉴别急性胸痛类型的装置及其应用
WO2025230312A1 (ko) * 2024-04-30 2025-11-06 주식회사 메디웨일 전신질환 위험도 기반 대상체 맞춤형 처방 지원 방법 및 장치
CN118152994B (zh) * 2024-05-11 2024-07-16 四川开物信息技术有限公司 一种安全因素影响计算方法
CN119517393A (zh) * 2024-10-29 2025-02-25 中国疾病预防控制中心慢性非传染性疾病预防控制中心 脑卒中发病风险评估方法及系统

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110144914A1 (en) * 2009-12-09 2011-06-16 Doug Harrington Biomarker assay for diagnosis and classification of cardiovascular disease
WO2013049674A1 (en) * 2011-09-30 2013-04-04 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof

Family Cites Families (248)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642284A (en) 1983-06-13 1987-02-10 Scripps Clinic And Research Foundation Method and system for detection of complement pathway activation
JPS60192263A (ja) 1984-03-13 1985-09-30 Teijin Ltd 免疫複合体測定用標準物質及びそれを用いた免疫複合体の測定法
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US6287793B1 (en) 1988-08-19 2001-09-11 Elan Pharmaceuticals, Inc. Diagnostic methods for alzheimer's disease
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
KR970002255B1 (ko) 1990-06-11 1997-02-26 넥스스타 파아마슈티컬드, 인크. 핵산 리간드
AT398004B (de) 1992-04-14 1994-08-25 Berbi Gmbh Verfahren zur bestimmung von plasmin-alpha2- antiplasmin-komplexen unter verwendung eines komplexspezifischen monoklonalen antikörpers
EP0574599A1 (en) 1992-06-13 1993-12-22 BEHRINGWERKE Aktiengesellschaft Process for the detection of complexed cathepsin G and alpha-1-antichymotrypsin
CA2162121A1 (en) 1993-05-17 1994-11-24 Richard W. Wicks Assay for cardiac troponin i
US6458539B1 (en) 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
US5599677A (en) 1993-12-29 1997-02-04 Abbott Laboratories Immunoassays for prostate specific antigen
CA2194660C (en) 1994-07-08 2009-09-29 Se-Jin Lee Growth differentiation factor-11
US5814464A (en) 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
FR2729759A1 (fr) 1995-01-19 1996-07-26 Pasteur Sanofi Diagnostics Procede de dosage ultrasensible de la troponine i cardiaque
EP0821728B1 (en) 1995-04-06 2004-08-11 Regeneron Pharmaceuticals, Inc. Tie-2 ligands, methods of making and uses thereof
US6991907B1 (en) 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US5795725A (en) 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
DE69633780T3 (de) 1995-04-18 2011-05-05 Biosite Incorporated, San Diego Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassays
FI104857B (fi) 1996-01-15 2000-04-14 Hytest Oy Sydänlihaksen soluvaurioiden asteen mittaus immunokemiallisella menetelmällä sisältäen menetelmään soveliaat vasta-aineet
US7285418B2 (en) 1996-06-25 2007-10-23 Hytest Ltd. Method and kit for the diagnosis of troponin I
DE69724636T2 (de) 1996-06-25 2004-09-16 Hytset Ltd. Verfahren und kit zur diagnose von troponin i
US6265564B1 (en) 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US6156521A (en) 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
WO1998029726A2 (en) 1996-12-27 1998-07-09 Coulter International Corp. Method of detecting and determining the concentration of total troponin i in a biological sample
CA2290582C (en) 1997-05-14 2005-08-02 Kenneth F. Buechler Rapid evaluation of the ratio of biological molecules
US7384751B1 (en) 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
AU6117099A (en) 1998-10-21 2000-05-08 Spectral Diagnostics Inc. Cardiac troponin i polypeptide fragments and uses in diagnostics
US20020110523A1 (en) 1999-03-23 2002-08-15 Cornelis Kluft Methods for screening or monitoring the risk of cardiovascular disease relating to sex steroid compound or composition intake and methods for screening sex steroid compound
US20030077668A1 (en) 1999-07-22 2003-04-24 Ikagaku Co., Ltd. Method for arteriosclerosis diagnosis
US7618782B1 (en) 1999-10-18 2009-11-17 Queen's University At Kingston Methods of diagnosing muscle damage
US20050272055A1 (en) 2000-02-01 2005-12-08 Rina Das Method of treating lethal shock induced by toxic agents and diagnosing exposure to toxic agents by measuring distinct pattern in the levels of expression of specific genes
US20030040505A1 (en) 2000-03-31 2003-02-27 The Regents Of The University Of California Synthetic phospholipids to ameliorate atherosclerosis and other inflammatory conditions
AUPR005600A0 (en) 2000-09-12 2000-10-05 University Of Sydney, The Diagnostic assay
AU2001296305B2 (en) 2000-09-26 2007-12-06 Duke University RNA aptamers and methods for identifying the same
WO2002063302A1 (en) 2001-02-07 2002-08-15 Immunomatrix Inc. A method for reducing heparin interference in diagnostic tests for cardiac troponin
US7524635B2 (en) 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20030199000A1 (en) 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040203083A1 (en) 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040253637A1 (en) 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
DE60233301D1 (de) 2001-05-04 2009-09-24 Biosite Inc Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
US20020197741A1 (en) 2001-05-11 2002-12-26 Sabucedo Albert J. Method of determining time of death
PT1401853E (pt) 2001-05-25 2010-12-07 Univ Duke Modulador de oligonucleotídeos
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
US20030003503A1 (en) 2001-06-29 2003-01-02 Tsai Tenlin S. Enhancing sensitivity and equimolar detection through modifications of the reaction environment
CA2453141A1 (en) 2001-07-09 2003-01-23 Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University Afinity biosensor for monitoring of biological process
US7608406B2 (en) 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6461828B1 (en) 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
JP2005510696A (ja) 2001-11-27 2005-04-21 ダイアジェニクス インターナショナル コーポレーション 患者サンプル中の生化学的標識の迅速同時検出のための免疫分析法および免疫分析キット
US7371582B2 (en) 2002-01-23 2008-05-13 Boditechmed Inc. Lateral flow quantitative assay method and strip and laser-induced fluorescence detection device therefor
DE10211818B4 (de) 2002-03-16 2006-07-06 peS Gesellschaft für medizinische Diagnose-Systeme mbH Verfahren zur quantitativen Bestimmung mehrerer Analyten
US6930085B2 (en) 2002-04-05 2005-08-16 The Regents Of The University Of California G-type peptides to ameliorate atherosclerosis
EP2301959A3 (en) 2002-04-09 2013-03-13 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
WO2003094856A2 (en) 2002-05-09 2003-11-20 The Brigham And Women's Hospital, Inc. 1l1rl-1 as a cardiovascular disease marker and therapeutic target
WO2003097872A2 (en) 2002-05-21 2003-11-27 Mtm Laboratories Ag G - protein coupled receptor marker molecules associated with colorectal lesions
EP1530723A1 (en) 2002-07-03 2005-05-18 Spinelix 3d microarray
US20040018577A1 (en) 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
NZ539734A (en) 2002-10-09 2011-07-29 Dmi Biosciences Inc Diagnosis and monitoring of inflammation, ischemia and appendicitis
US7135329B2 (en) 2002-11-18 2006-11-14 Princeton Biomeditech Corporation Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
EP1620567A1 (en) 2003-04-15 2006-02-01 Hans-Jürgen Thiesen Method for diagnosing rheumatoid arthritis or osteoarthritis
FI20030652A0 (fi) 2003-04-30 2003-04-30 Susann Eriksson Parannettu immunomääritys
US7659062B2 (en) 2003-06-03 2010-02-09 The Board of Trustee of the University of Arkansas System Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
US7927795B2 (en) 2003-06-09 2011-04-19 Board Of Trustees Of The University Of Arkansas Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium
WO2005010213A2 (en) 2003-07-17 2005-02-03 Pacific Edge Biotechnology, Ltd. Markers for detection of gastric cancer
WO2005024603A2 (en) 2003-09-10 2005-03-17 The Board Of Regents Of The University Of Texas System Methods for detecting, diagnosing and treating human renal cell carcinoma
US20050181386A1 (en) 2003-09-23 2005-08-18 Cornelius Diamond Diagnostic markers of cardiovascular illness and methods of use thereof
US20080010024A1 (en) 2003-09-23 2008-01-10 Prediction Sciences Llp Cellular fibronectin as a diagnostic marker in cardiovascular disease and methods of use thereof
US7634360B2 (en) 2003-09-23 2009-12-15 Prediction Sciences, LL Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US7392140B2 (en) 2003-09-23 2008-06-24 Prediction Sciences, Llc Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof
US20050148029A1 (en) 2003-09-29 2005-07-07 Biosite, Inc. Methods and compositions for determining treatment regimens in systemic inflammatory response syndromes
EP1673465A4 (en) 2003-09-29 2008-04-30 Biosite Inc PROCESS AND COMPOSITIONS FOR SEPSIS DIAGNOSIS
DE10349124A1 (de) 2003-10-22 2005-05-19 Roche Diagnostics Gmbh Differenzialdiagnostik mit Hepcidin
US20050239706A1 (en) 2003-10-31 2005-10-27 Washington University In St. Louis Modulation of fiaf and the gastrointestinal microbiota as a means to control energy storage in a subject
EP1530047A1 (en) * 2003-11-07 2005-05-11 Roche Diagnostics GmbH Proximal markers of arterial thrombosis and inflammation for risk stratification of coronary heart disease
DK2211183T3 (da) 2003-11-19 2013-05-13 Satoris Inc Fremgangsmåde til diagnosticering og overvågning af Alzheimer's sygdom
US20050164409A1 (en) 2003-12-10 2005-07-28 Kiernan Urban A. Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins
US8932808B1 (en) 2004-01-21 2015-01-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for determining a graft tolerant phenotype in a subject
US7666583B2 (en) 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
CA2848463A1 (en) 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
EP1737497A2 (en) 2004-04-13 2007-01-03 (Osi) Eyetech, Inc. Nucleic acid aptamers conjugated to high molecular weight steric groups
WO2005113798A2 (en) 2004-04-15 2005-12-01 University Of Florida Research Foundation, Inc. Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining
AU2005242719B2 (en) 2004-05-11 2011-02-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
US20060039863A1 (en) 2004-07-22 2006-02-23 Michael Schirner Use of cyanine dyes for the diagnosis of disease associated with angiogenesis
US20060105419A1 (en) 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
US20080090759A1 (en) 2004-08-30 2008-04-17 Robert Kokenyesi Methods and kits for predicting risk for preterm labor
US20080193461A1 (en) 2004-12-20 2008-08-14 The General Hospital Corporation Use of Angiopoietins in Tumor Therapy
US20060134698A1 (en) 2004-12-20 2006-06-22 Evanston Northwestern Healthcare Research Institute Methods for treating cardiac disease by modifying an N-terminal domain of troponin I
WO2006070734A1 (ja) 2004-12-27 2006-07-06 National University Corporation Okayama University 妊娠中毒症の検査方法
US8178505B2 (en) 2005-01-05 2012-05-15 Sloan-Kettering Institute For Cancer Research Method of predicting and reducing risk of metastasis of breast cancer to lung
CA2599731A1 (en) 2005-03-03 2006-09-08 Dmi Biosciences, Inc. Quantification of proteins
CN101185000A (zh) 2005-03-29 2008-05-21 因弗因斯医药瑞士股份有限公司 监测患者的方法和装置
EP1877796A2 (en) 2005-05-05 2008-01-16 Philadelphia Health & Education Corporation d/b/a Diagnosis of liver pathology through assessment of protein glycosylation
GB0509305D0 (en) 2005-05-06 2005-06-15 Randox Lab Ltd Method
US20060275849A1 (en) 2005-06-07 2006-12-07 Beckman Coulter, Inc. Monoclonal antibody reagents
WO2006133399A1 (en) 2005-06-08 2006-12-14 Hitachi Chemical Research Center, Inc. METHOD FOR PREDICTING IMMUNE RESPONSE TO NEOPLASTIC DISEASE BASED ON mRNA EXPRESSION PROFILE IN NEOPLASTIC CELLS AND STIMULATED LEUKOCYTES
WO2006135781A2 (en) 2005-06-09 2006-12-21 Biosite, Inc. Methods and compositions for the diagnosis of venous thromboembolic disease
US20070099239A1 (en) 2005-06-24 2007-05-03 Raymond Tabibiazar Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease
WO2007000048A1 (en) 2005-06-28 2007-01-04 Zbx Corporation Membrane array and analytical device
EP1929295A4 (en) 2005-08-30 2010-03-17 Biosite Inc USE OF SOLUBLE FLT-1 AND ITS FRAGMENTS IN CARDIOVASCULAR CONDITIONS
US20070154482A1 (en) 2005-09-12 2007-07-05 Beth Israel Deaconess Medical Center Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
CA2624569A1 (en) 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US7947437B2 (en) 2005-10-17 2011-05-24 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US20100267025A1 (en) 2005-11-10 2010-10-21 Robert Peter Young Methods and compositions for the assessment of cardiovascular function and disorders
US7908090B2 (en) 2005-11-30 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Signatures for human aging
US20140273007A1 (en) 2013-03-12 2014-09-18 Dr. Susan Love Research Foundation Devices and methods for screening nipple aspirate for markers indicative of risk of developing breast cancer
US20070134814A1 (en) 2005-12-09 2007-06-14 Kajander E O Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease
WO2007070021A1 (en) 2005-12-09 2007-06-21 Nanobac Pharmaceuticals Incorporated Detection of calcifying nano-particles, and associated proteins thereon
US7790463B2 (en) 2006-02-02 2010-09-07 Yale University Methods of determining whether a pregnant woman is at risk of developing preeclampsia
HUE026496T2 (en) 2006-03-08 2016-06-28 Archemix Llc Complement-binding aptamers and anti-C5 agents for treating eye diseases
EP2005168A4 (en) 2006-03-09 2009-05-20 Biosite Inc METHODS AND COMPOSITIONS FOR DIAGNOSING DISEASES OF AORTA
EP2007899B1 (en) 2006-03-20 2017-06-07 Celldex Therapeutics, Inc. Antibodies directed to angiopoietin-like protein 4 and uses thereof
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP2016394A4 (en) 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
WO2007127749A2 (en) 2006-04-24 2007-11-08 Critical Care Diagnostics, Inc. Predicting mortality and detecting severe disease
US20100055730A1 (en) 2006-05-05 2010-03-04 Anny Usheva-Simidjiyska Methods for the Diagnosis and Treatment of Female Infertility Using Molecular Markers
EP2407562A1 (en) 2006-05-08 2012-01-18 Tethys Bioscience, Inc. Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets
US20080118924A1 (en) 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
AU2007277186B2 (en) 2006-07-28 2014-01-30 Presympto, Inc. Peptide probes for diagnostics and therapeutics
EP1887361A1 (en) 2006-08-07 2008-02-13 Bio-Rad Pasteur Method for the prediction of vascular events
EP2469283B1 (en) 2006-09-08 2014-01-15 The Chancellor, Masters and Scholars of the University of Oxford Clinical diagnosis of hepatic fibrosis using human serum APOL1 as biomarker
WO2008034016A2 (en) 2006-09-15 2008-03-20 Foldrx Pharmaceuticals, Inc. Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins
BRPI0717803A2 (pt) 2006-10-06 2013-11-19 Nestec Sa Composições e ensaios multiplicadores para a medição de mediadores biológicos de saúde fisiológica
US20080305512A1 (en) 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
US7776605B2 (en) 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
EP2129795A4 (en) 2006-12-19 2010-10-20 Synergenz Bioscience Ltd METHODS AND COMPOSITIONS FOR ASSESSING FUNCTION AND CARDIOVASCULAR DISORDERS
RU2473555C2 (ru) * 2006-12-19 2013-01-27 ДжинГоу, Инк. Новые способы функционального анализа большого количества экспериментальных данных и групп генов, идентифицированных из указанных данных
JP5439187B2 (ja) 2006-12-20 2014-03-12 アンチボディショップ・アクティーゼルスカブ 抗炎症性剤および／または抗凝固剤による治療的介入についての要件を決定するための敗血症患者の評価
WO2008080126A2 (en) 2006-12-22 2008-07-03 Aviir, Inc. Two biomarkers for diagnosis and monitoring of atherosclerotic cardiovascular disease
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
US20080300798A1 (en) 2007-04-16 2008-12-04 Mcdevitt John T Cardibioindex/cardibioscore and utility of salivary proteome in cardiovascular diagnostics
US7901888B2 (en) 2007-05-09 2011-03-08 The Regents Of The University Of California Multigene diagnostic assay for malignant thyroid neoplasm
AU2008251822B2 (en) 2007-05-10 2014-02-06 Acorda Therapeutics, Inc. Methods for detecting cardiac damage
SI2489743T1 (sl) 2007-07-17 2015-04-30 Somalogic, Inc. Aptameri s 5-(N-naftilno) substituiranimi uridini
EP2019318A1 (en) 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Protein markers for cardiovascular events
WO2010012509A1 (en) 2008-08-01 2010-02-04 Bio-Rad Pasteur Method for the in vitro diagnosis of stroke
US7888051B2 (en) 2007-09-11 2011-02-15 Cancer Prevention And Cure, Ltd. Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues
CA2707986A1 (en) 2007-12-13 2009-06-18 Glaxo Group Limited Compositions for pulmonary delivery
GB0724735D0 (en) 2007-12-19 2008-01-30 Psynova Neurotech Ltd Methods and biomarkers for diagnosing and monitoring psychotic disorders
US20100016173A1 (en) 2008-01-30 2010-01-21 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia
US20090299155A1 (en) 2008-01-30 2009-12-03 Dexcom, Inc. Continuous cardiac marker sensor system
WO2009108073A1 (en) 2008-02-28 2009-09-03 Auckland Uniservices Limited Biomarkers for prediction of preeclampsia and/or cardiovascular disease
EP2265950B1 (en) 2008-03-05 2019-01-23 Axela Inc. Detection of biomarkers and biomarker complexes
CN102016552A (zh) 2008-03-05 2011-04-13 神谷来克斯公司 用于分子的高灵敏性检测的方法和组合物
WO2009118185A1 (en) 2008-03-27 2009-10-01 Universitätsklinikum Heidelberg Peptides derived from cardial troponin i and their use as prognostic and diagnostic markers for heart failure
HUE029880T2 (en) 2008-04-18 2017-04-28 Critical Care Diagnostics Inc Predicting the risk of serious heart events
FR2934767B1 (fr) 2008-08-06 2011-11-25 Assist Publ Hopitaux De Paris Nouveau procede de pronostic associe aux cas d'hemorragies post-partum.
GB0818660D0 (en) 2008-10-10 2008-11-19 Cambridge Entpr Ltd Biomarkers
US20110295782A1 (en) 2008-10-15 2011-12-01 Alexander Stojadinovic Clinical Decision Model
CA2741087A1 (en) 2008-10-21 2010-04-29 Bayer Healthcare Llc Identification of signature genes associated with hepatocellular carcinoma
KR20110081846A (ko) 2008-10-24 2011-07-14 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 미네랄로코르티코이드 수용체 활성화의 바이오마커
CA3013992A1 (en) 2008-12-30 2010-07-08 Children's Medical Center Corporation Method of predicting acute appendicitis
CN105388293A (zh) 2008-12-31 2016-03-09 雅培医护站股份有限公司 用于使用核苷酸缀合物的免疫测定的方法和设备
AU2009339152B2 (en) 2009-01-30 2015-11-19 Bio-Rad Europe Gmbh Method for the in vitro diagnosis of stroke
US20100216256A1 (en) 2009-02-17 2010-08-26 Florida State University Research Foundation Nanobelt-based sensors and detection methods
CN102326081B (zh) 2009-02-24 2014-11-19 霍夫曼-拉罗奇有限公司 s-ErbB-3作为癌症标志物的应用
EP2425247A4 (en) 2009-04-28 2013-01-23 Innovative Lab Technologies Inc IMMUNOCHROMATOGRAPHIC LATERAL FLOW TEST DEVICES
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
WO2010144553A2 (en) 2009-06-10 2010-12-16 Tufts Medical Center, Inc. Methods for diagnosing blood vessel reocclusion
WO2011017077A2 (en) 2009-07-27 2011-02-10 Trustees Of Boston University Nanochannel-based sensor system with controlled sensitivity
WO2011022628A1 (en) 2009-08-20 2011-02-24 The Board Of Regents Of The University Of Texas System Methods and compositions for diagnosis of acute myocardial infarction (ami)
EP2473852B1 (en) 2009-08-31 2016-03-30 Abbott Laboratories Biomarkers for prediction of major adverse cardiac events and uses thereof
EP2480887B1 (en) 2009-09-23 2015-12-16 Koninklijke Philips N.V. Binding assay with multiple magnetically labelled tracer binding agents
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
US20120231472A1 (en) 2009-11-07 2012-09-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2013511732A (ja) 2009-11-24 2013-04-04 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション 神経障害の診断、診断補助および／またはその進行のモニタリングのための方法、キットおよび試薬
US8652788B2 (en) 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
US20110136141A1 (en) 2009-12-03 2011-06-09 Abbott Laboratories Peptide reagents and method for inhibiting autoantibody antigen binding
US20120258553A1 (en) 2009-12-23 2012-10-11 Koninklijke Philips Electronics N.V. Analyte measurement apparatus and method
CA2785592A1 (en) 2010-01-08 2011-07-14 Cavadis B.V. Determination of exosomel biomarkers for predicting cardiovascular events
WO2011089152A1 (en) 2010-01-20 2011-07-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the preservation of vascular endothelial cell barrier integrity
AU2011213686B2 (en) 2010-02-05 2015-11-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US10393754B2 (en) 2010-02-17 2019-08-27 Cedars-Sinai Medical Center Methods of diagnosing and treating heart failure
WO2011123386A1 (en) 2010-03-28 2011-10-06 Samar Kumar Kundu Methods for detecting raman scattering using aromatic compounds comprising phosphate and at least one non-laser light source
EP2372364A1 (en) 2010-03-31 2011-10-05 Medizinische Hochschule Hannover Biomarker for pulmonary hypertension
WO2011140484A1 (en) 2010-05-06 2011-11-10 Singulex, Inc Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis
WO2011143574A2 (en) 2010-05-14 2011-11-17 The Trustees Of The University Of Pennsylvania Plasma biomarkers for diagnosis of alzheimer's disease
CN103080743B (zh) 2010-06-23 2015-07-22 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
WO2011163661A1 (en) 2010-06-25 2011-12-29 Massachusetts Institute Of Technology Implantable magnetic relaxation sensors and methods of measuring a sensor's cumulative exposure to a biomarker
ES2387292B1 (es) 2010-06-29 2013-10-30 Fundacio Institut De Recerca Hospital Universitari Vall D'hebron Combinacion de snps para determinar el riesgo de sufrir una enfermedad neurovascular
MX355020B (es) 2010-07-09 2018-04-02 Somalogic Inc Biomarcadores de cancer de pulmon y usos de los mismos.
US20120015904A1 (en) * 2010-07-14 2012-01-19 Regents Of The University Of California Biomarkers for diagnosis of transient ischemic attacks
US20120142632A1 (en) 2010-08-04 2012-06-07 St. Vincent's Institute Of Medical Research Diagnostic and prognostic assay
WO2012019104A1 (en) 2010-08-05 2012-02-09 Abbott Point Of Care Inc. Immunoassay method and device with magnetically susceptible bead capture
US9329175B2 (en) 2010-08-05 2016-05-03 Abbott Point Of Care Inc. Oscillating immunoassay method and device
CN106011233A (zh) * 2010-08-13 2016-10-12 莫尔豪斯医学院 中风的生物标记
JP5676763B2 (ja) 2010-08-26 2015-02-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 動脈性高血圧症から心不全への初期移行の評価におけるバイオマーカーの使用
AU2011312491B2 (en) 2010-09-27 2015-06-04 Somalogic, Inc. Mesothelioma biomarkers and uses thereof
WO2012052757A1 (en) 2010-10-20 2012-04-26 Astrazeneca Ab Tumour phenotype patient selection method
US20120115175A1 (en) 2010-11-05 2012-05-10 Tufts Medical Center, Inc. Methods for diagnosing elevated right or left ventricular filling pressure
EP2638401B1 (en) 2010-11-12 2017-02-15 The Johns Hopkins University Citrullinated proteins: a post-translated modification of myocardial proteins as marker of physiological and pathological disease
CA2824434A1 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2671083A1 (en) 2011-02-03 2013-12-11 Abbott Laboratories Methods of prognosis and diagnosis in chronic heart failure
US20140024046A1 (en) 2011-02-18 2014-01-23 Cavadis B.V. Exosomal Biomarkers for Cardiovasular Events
CA2827894A1 (en) 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
US20140199781A1 (en) 2011-03-08 2014-07-17 Beth Israel Deaconess Medical Center, Inc. Non-invasive methods for diagnosing chronic organ transplant rejection
FI20115367A0 (fi) 2011-04-15 2011-04-15 Hytest Oy Menetelmä sydän- ja verisuonitapahtumien määrittämiseksi käyttämällä IGFBP-fragmentteja
AU2012249288C1 (en) 2011-04-29 2017-12-21 Lung Cancer Proteomics Llc Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
CN102816764A (zh) 2011-06-07 2012-12-12 浦项工科大学校产学协力团 特异性结合于人心肌肌钙蛋白ⅰ的dna适体
US9387236B2 (en) 2011-06-10 2016-07-12 Prothera Inc. Pharmaceutical compositions containing protease and methods for the treatment of lysosomal storage diseases
EP2734222B1 (en) 2011-07-18 2016-10-19 Critical Care Diagnostics, Inc. Methods of treating cardiovascular diseases and predicting the efficacy of exercise therapy
CN107536847A (zh) 2011-08-08 2018-01-05 南洋理工大学 血管生成素样4及其在调节细胞渗漏中的用途
KR20140067001A (ko) 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
WO2013036913A1 (en) 2011-09-08 2013-03-14 Nexus Dx, Inc. A multilevel analyte assay
EP2594940A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Particle repulsion to enhance surface contact in magnetic particle immunoassays
EP2594942A1 (en) 2011-11-16 2013-05-22 Koninklijke Philips Electronics N.V. Long rigid spacers to enhance binding kinetics in immunoassays
WO2013085367A1 (en) 2011-12-09 2013-06-13 Kyungpook National University Industry-Academic Cooperation Foundation Cardiac troponin i-targeting peptide and use thereof
US8986530B2 (en) 2012-01-09 2015-03-24 Washington State University Sample analysis systems, devices, and associated methods of operation
US9140695B2 (en) 2012-01-18 2015-09-22 University Of Utah Research Foundation Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems
CA2957365A1 (en) 2012-02-27 2013-09-06 University Health Network (Uhn) Biomarkers for early determination of a critical or life threatening response to illness and monitoring response to treatment thereof
EP2825665B1 (en) * 2012-03-14 2017-09-06 Ruprecht-Karls-Universität Heidelberg Epigenetic signatures as marker for cardiomyopathies and myocardial insufficiencies
EP3968026A1 (en) 2012-03-26 2022-03-16 XCellCure, LLC Device and method for detection of analytes
US20150293131A1 (en) 2012-04-02 2015-10-15 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
WO2013155614A1 (en) 2012-04-18 2013-10-24 The University Of British Columbia Biomarkers for recovered heart function
WO2013163345A1 (en) 2012-04-24 2013-10-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
ES2762403T3 (es) 2012-04-26 2020-05-25 Stichting Vumc Biomarcadores
WO2013169890A1 (en) 2012-05-08 2013-11-14 Bg Medicine, Inc. Systems and methods for assessing disease risk, status, and prognosis
CN104507383B (zh) 2012-05-18 2018-08-28 重症监护诊断股份有限公司 用于治疗或预报室性快速性心律失常事件风险的方法
ITMI20120865A1 (it) 2012-05-18 2013-11-19 Antonio Bertolotto Biomarcatori per patologie del sistema nervoso centrale
US9482616B2 (en) 2012-06-06 2016-11-01 Board of Regents of the Nevada System of Higher Education, on behalf the University of Nevada, Reno Methods, kits and systems for signal amplification for bioassays using zinc nanoparticles
US10175250B2 (en) 2012-06-11 2019-01-08 Gabriela Venturini Da Silva Nitrated cardiac troponin I as a biomarker of cardiac ischemia
US20150203916A1 (en) 2012-06-27 2015-07-23 Music Foundation For Research Development Plasma analytes predict diagnosis and prognosis of thoracic aortic aneurysm
CN104737023B (zh) 2012-08-16 2017-07-28 重症监护诊断股份有限公司 预测患高血压风险的方法
US20140120551A1 (en) 2012-10-29 2014-05-01 Academia Sinica Methods of diagnosing, predicting and treating cardiovascular disease
US10309954B2 (en) 2012-12-12 2019-06-04 Green Domain Design Llc Assay apparatus
US20140206632A1 (en) 2013-01-22 2014-07-24 Singulex, Inc. Endothelin in the Diagnosis of Cardiac Disease
EP2953524B1 (en) 2013-02-06 2018-08-01 Freenome Holdings Inc. Systems and methods for early disease detection and real-time disease monitoring
WO2014127265A1 (en) 2013-02-14 2014-08-21 Singulex, Inc. Non-invasive methods to determine vulnerable plaque burden in subjects
WO2014144605A1 (en) 2013-03-15 2014-09-18 Myriad Genetics, Inc. Biomarkers for major depressive disorder
WO2014187884A2 (en) 2013-05-22 2014-11-27 Comprehensive Biomarker Center Gmbh Mirnas as non-invasive biomarkers for heart failure
US9884090B2 (en) * 2013-09-03 2018-02-06 Mayo Foundation For Medical Education And Research Using nucleic acids encoding NAP-2 and TGF-alpha polypeptides to improve cardiac function
GB201315943D0 (en) 2013-09-06 2013-10-23 Randox Lab Ltd Risk stratification of suspected ami patients
GB2518221A (en) 2013-09-16 2015-03-18 Sergej Michailovic Kiprijanov Tetravalent antigen-binding protein molecule
WO2015042465A1 (en) 2013-09-20 2015-03-26 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
EP3052936A4 (en) 2013-09-23 2017-05-24 Assaypro, LLC Immunoassays using over-labeled fluorescent probes
GB2519786A (en) 2013-10-30 2015-05-06 Sergej Michailovic Kiprijanov Multivalent antigen-binding protein molecules
WO2015073396A1 (en) * 2013-11-12 2015-05-21 The Brigham And Women's Hospital, Inc. Growth differentiation factor (gdf) for treatment of diastolic heart failure
US20160305959A1 (en) * 2013-11-14 2016-10-20 THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN Detection of atherosclerotic cardiovascular disease risk
WO2015085368A1 (en) 2013-12-10 2015-06-18 The University Of Queensland Kits and methods for the diagnosis, treatment, prevention and monitoring of diabetes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110144914A1 (en) * 2009-12-09 2011-06-16 Doug Harrington Biomarker assay for diagnosis and classification of cardiovascular disease
JP2013513387A (ja) * 2009-12-09 2013-04-22 アヴィール インコーポレイテッド 循環器疾患の診断と分類のためのバイオマーカーアッセイ
WO2013049674A1 (en) * 2011-09-30 2013-04-04 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021507216A (ja) * 2017-12-13 2021-02-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 脳卒中の予測のための循環アンジオポエチン−２（Ａｎｇ−２）およびインスリン様増殖因子結合タンパク質７（ＩＧＦＢＰ７）
JP7058331B2 (ja) 2017-12-13 2022-04-21 エフ．ホフマン－ラ ロシュ アーゲー 脳卒中の予測のための循環アンジオポエチン－２（Ａｎｇ－２）およびインスリン様増殖因子結合タンパク質７（ＩＧＦＢＰ７）
US11946938B2 (en) 2017-12-13 2024-04-02 Roche Diagnostics Operations, Inc. Circulating Angiopoietin-2 (Ang-2) and insulin-like growth factor-binding protein 7 (IGFBP7) for the prediction of stroke
JP2022546515A (ja) * 2019-09-03 2022-11-04 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管リスク／イベントの予測及びその使用
JP7712913B2 (ja) 2019-09-03 2025-07-24 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管リスク／イベントの予測及びその使用
JP2023502984A (ja) * 2019-11-15 2023-01-26 ゲイシンガー クリニック ヘルスケア集団の管理に対する機械学習手法のためのシステムおよび方法
JP7700114B2 (ja) 2019-11-15 2025-06-30 ゲイシンガー クリニック ヘルスケア集団の管理に対する機械学習手法のためのシステムおよび方法
JP2023546563A (ja) * 2020-10-20 2023-11-06 ソマロジック オペレーティング カンパニー インコーポレイテッド 心血管イベントリスクの予測

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