JP2017528524A5 - - Google Patents
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- Publication number
- JP2017528524A5 JP2017528524A5 JP2017534871A JP2017534871A JP2017528524A5 JP 2017528524 A5 JP2017528524 A5 JP 2017528524A5 JP 2017534871 A JP2017534871 A JP 2017534871A JP 2017534871 A JP2017534871 A JP 2017534871A JP 2017528524 A5 JP2017528524 A5 JP 2017528524A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- amino
- nitro
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462052617P | 2014-09-19 | 2014-09-19 | |
| US62/052,617 | 2014-09-19 | ||
| PCT/CN2015/089865 WO2016041511A1 (en) | 2014-09-19 | 2015-09-17 | Benzo-heterocyclic compounds and their applications |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170524A Division JP2021008502A (ja) | 2014-09-19 | 2020-10-08 | ベンゾ複素環化合物および医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017528524A JP2017528524A (ja) | 2017-09-28 |
| JP2017528524A5 true JP2017528524A5 (online.php) | 2018-10-18 |
| JP6777638B2 JP6777638B2 (ja) | 2020-10-28 |
Family
ID=55532567
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534871A Expired - Fee Related JP6777638B2 (ja) | 2014-09-19 | 2015-09-17 | ベンゾ複素環化合物および薬剤 |
| JP2020170524A Pending JP2021008502A (ja) | 2014-09-19 | 2020-10-08 | ベンゾ複素環化合物および医薬組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020170524A Pending JP2021008502A (ja) | 2014-09-19 | 2020-10-08 | ベンゾ複素環化合物および医薬組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20170283408A1 (online.php) |
| EP (1) | EP3194368B1 (online.php) |
| JP (2) | JP6777638B2 (online.php) |
| KR (1) | KR20170090408A (online.php) |
| CN (1) | CN107087409B (online.php) |
| AU (1) | AU2015317566B2 (online.php) |
| TW (1) | TW201625527A (online.php) |
| WO (1) | WO2016041511A1 (online.php) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| MD3377488T2 (ro) | 2015-11-19 | 2023-02-28 | Incyte Corp | Compuși heterociclici ca imunomodulatori |
| MA44075A (fr) | 2015-12-17 | 2021-05-19 | Incyte Corp | Dérivés de n-phényl-pyridine-2-carboxamide et leur utilisation en tant que modulateurs des interactions protéine/protéine pd-1/pd-l1 |
| MY199705A (en) | 2015-12-22 | 2023-11-20 | Incyte Corp | Heterocyclic compounds as immunomodulators |
| WO2017192961A1 (en) | 2016-05-06 | 2017-11-09 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| WO2017205464A1 (en) | 2016-05-26 | 2017-11-30 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| KR102685249B1 (ko) | 2016-06-20 | 2024-07-17 | 인사이트 코포레이션 | 면역조절제로서의 복소환식 화합물 |
| MA45669A (fr) | 2016-07-14 | 2019-05-22 | Incyte Corp | Composés hétérocycliques utilisés comme immunomodulateurs |
| WO2018044783A1 (en) | 2016-08-29 | 2018-03-08 | Incyte Corporation | Heterocyclic compounds as immunomodulators |
| EP3558989B1 (en) | 2016-12-22 | 2021-04-14 | Incyte Corporation | Triazolo[1,5-a]pyridine derivatives as immunomodulators |
| CA3047991A1 (en) | 2016-12-22 | 2018-06-28 | Incyte Corporation | Bicyclic heteroaromatic compounds as immunomodulators |
| PE20191532A1 (es) * | 2016-12-22 | 2019-10-23 | Incyte Corp | Compuestos heterociclicos como inmunomoduladores |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| RS64055B1 (sr) | 2018-03-30 | 2023-04-28 | Incyte Corp | Heterociklična jedinjenja kao imunomodulatori |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| MD3790877T2 (ro) | 2018-05-11 | 2023-08-31 | Incyte Corp | Derivați de tetrahidro-imidazo[4,5-c]piridină în calitate de imunomodulatori PD-L1 |
| CN108774219B (zh) * | 2018-05-17 | 2021-05-04 | 中国药科大学 | 抑制pd-1/pd-l1的小分子化合物及其用途 |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| KR102211062B1 (ko) | 2019-02-27 | 2021-02-02 | 충남대학교산학협력단 | 신규한 나프탈이미드-벤조사이아졸 화합물 및 이를 포함하는 시아나이드 이온 및 트립토판 아미노산의 선택적 검출이 가능한 화학센서 |
| CN109970729B (zh) * | 2019-03-12 | 2024-01-26 | 西北农林科技大学 | 一种氟离子探针聚集态荧光增强型染料的合成方法 |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| CN110407865B (zh) * | 2019-08-02 | 2022-04-15 | 山东师范大学 | 基于苯磺酰胺结构的式（i）化合物及其制备方法与应用 |
| JP7665593B2 (ja) | 2019-08-09 | 2025-04-21 | インサイト・コーポレイション | Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩 |
| AR120109A1 (es) | 2019-09-30 | 2022-02-02 | Incyte Corp | Compuestos de pirido[3,2-d]pirimidina como inmunomoduladores |
| PE20230407A1 (es) | 2019-11-11 | 2023-03-07 | Incyte Corp | Sales y formas cristalinas de un inhibidor de pd-1/pd-l1 |
| CA3169348A1 (en) | 2020-03-20 | 2021-09-23 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| BR112022022335A2 (pt) | 2020-05-05 | 2023-01-10 | Teon Therapeutics Inc | Moduladores de receptor canabinoide tipo 2 (cb2) e usos dos mesmos |
| CN112250682B (zh) * | 2020-11-02 | 2021-12-07 | 河南大学 | 一种芳杂环修饰的萘酰亚胺衍生物及其制备方法和用途 |
| TW202233616A (zh) | 2020-11-06 | 2022-09-01 | 美商英塞特公司 | 用於製備ｐｄ－１／ｐｄ－ｌ１抑制劑以及其鹽及結晶形式之方法 |
| WO2022099075A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Crystalline form of a pd-1/pd-l1 inhibitor |
| WO2022099018A1 (en) | 2020-11-06 | 2022-05-12 | Incyte Corporation | Process of preparing a pd-1/pd-l1 inhibitor |
| TW202325306A (zh) | 2021-09-02 | 2023-07-01 | 美商天恩治療有限公司 | 改良免疫細胞之生長及功能的方法 |
| WO2023081730A1 (en) | 2021-11-03 | 2023-05-11 | Teon Therapeutics, Inc. | 4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide derivatives as cannabinoid cb2 receptor modulators for the treatment of cancer |
| WO2023097211A1 (en) | 2021-11-24 | 2023-06-01 | The University Of Southern California | Methods for enhancing immune checkpoint inhibitor therapy |
| EP4554943A1 (en) | 2022-07-14 | 2025-05-21 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| CN115385890B (zh) * | 2022-07-19 | 2023-08-08 | 杭州庆正鸿科技有限公司 | 一种1,8萘酰亚胺衍生物及其制备方法与应用 |
| CN117143076A (zh) * | 2023-09-01 | 2023-12-01 | 河南大学 | 喹喔啉修饰的萘酰亚胺-多胺缀合物及其制备方法和应用 |
| CN117285546A (zh) * | 2023-09-08 | 2023-12-26 | 河南大学 | 咪唑并噻唑修饰的萘酰亚胺-多胺缀合物、制备方法和用途 |
| WO2026035860A1 (en) | 2024-08-07 | 2026-02-12 | Teon Therapeutics, Inc. | Formulations of adenosine receptor antagonist |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423548C2 (de) * | 1974-05-15 | 1984-08-23 | Hoechst Ag, 6230 Frankfurt | Verfahren zur Herstellung von 4-Amino1,8-naphthalimid-Verbindungen |
| DE3942280A1 (de) * | 1989-12-21 | 1991-06-27 | Knoll Ag | N-substituierte naphthalimide, ihre herstellung und verwendung |
| BR9915648A (pt) * | 1998-11-25 | 2001-08-14 | Merck Patent Gmbh | Benzo [de] isoquinolina-1,3-dionas substituìdas |
| CN1857221A (zh) * | 2006-04-14 | 2006-11-08 | 济南帅华医药科技有限公司 | 一种同载铂类化合物及其增效剂的抗癌缓释剂 |
| EP2118065B1 (en) * | 2007-01-11 | 2013-08-14 | Council of Scientific & Industrial Research | Substituted 1H-benz[de]isoquinoline-1,3-diones |
| HUP0700433A2 (en) * | 2007-06-21 | 2009-03-30 | Avidin Kutato | Compounds influencing development or functioning of cellular vesicular systems particularly lipid droplets, pharmaceutical compositions containing these compounds and use them for treatment of illnesses |
| US8420665B2 (en) * | 2008-01-11 | 2013-04-16 | Northwestern University | Anti-cancer compounds |
| CN102206203B (zh) * | 2011-04-04 | 2013-06-19 | 大连理工大学 | 含有苯并咪唑的萘酰亚胺衍生物的合成及其在抗肿瘤上的应用 |
| CN102731493B (zh) * | 2012-07-08 | 2014-06-25 | 大连理工大学 | 一类抗肿瘤含苯并噻唑杂环结构的化合物及其应用 |
-
2015
- 2015-09-17 TW TW104130845A patent/TW201625527A/zh unknown
- 2015-09-17 JP JP2017534871A patent/JP6777638B2/ja not_active Expired - Fee Related
- 2015-09-17 AU AU2015317566A patent/AU2015317566B2/en not_active Ceased
- 2015-09-17 KR KR1020177010627A patent/KR20170090408A/ko not_active Ceased
- 2015-09-17 US US15/512,248 patent/US20170283408A1/en not_active Abandoned
- 2015-09-17 WO PCT/CN2015/089865 patent/WO2016041511A1/en not_active Ceased
- 2015-09-17 CN CN201580050353.5A patent/CN107087409B/zh not_active Expired - Fee Related
- 2015-09-17 EP EP15843004.1A patent/EP3194368B1/en not_active Not-in-force
-
2020
- 2020-07-09 US US16/925,309 patent/US20200339557A1/en not_active Abandoned
- 2020-10-08 JP JP2020170524A patent/JP2021008502A/ja active Pending
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