JP2017528507A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017528507A5 JP2017528507A5 JP2017516387A JP2017516387A JP2017528507A5 JP 2017528507 A5 JP2017528507 A5 JP 2017528507A5 JP 2017516387 A JP2017516387 A JP 2017516387A JP 2017516387 A JP2017516387 A JP 2017516387A JP 2017528507 A5 JP2017528507 A5 JP 2017528507A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- pharmaceutical composition
- pharmaceutically acceptable
- naphthyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000003176 fibrotic Effects 0.000 claims 3
- 201000009794 idiopathic pulmonary fibrosis Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- MKIJZIVRJUMEAD-AMGIVPHBSA-N COCCOC1=CC=CC(=C1)[C@@H](CN1CC[C@@](F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O Chemical compound COCCOC1=CC=CC(=C1)[C@@H](CN1CC[C@@](F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O MKIJZIVRJUMEAD-AMGIVPHBSA-N 0.000 claims 2
- XZXHXSATPCNXJR-ZIADKAODSA-N Nintedanib Chemical group O=C1NC2=CC(C(=O)OC)=CC=C2\C1=C(C=1C=CC=CC=1)\NC(C=C1)=CC=C1N(C)C(=O)CN1CCN(C)CC1 XZXHXSATPCNXJR-ZIADKAODSA-N 0.000 claims 2
- 230000003042 antagnostic Effects 0.000 claims 2
- 229960004378 nintedanib Drugs 0.000 claims 2
- 239000002464 receptor antagonist Substances 0.000 claims 2
- -1 3- (3- (2-methoxyethoxy) phenyl) butanoic acid maleate Chemical compound 0.000 claims 1
- MKIJZIVRJUMEAD-UHFFFAOYSA-N COCCOC1=CC=CC(=C1)C(CN1CCC(F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O Chemical compound COCCOC1=CC=CC(=C1)C(CN1CCC(F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O MKIJZIVRJUMEAD-UHFFFAOYSA-N 0.000 claims 1
- MKIJZIVRJUMEAD-CUNXSJBXSA-N COCCOC1=CC=CC(=C1)[C@H](CN1CC[C@@](F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O Chemical compound COCCOC1=CC=CC(=C1)[C@H](CN1CC[C@@](F)(CCC2=CC=C3CCCNC3=N2)C1)CC(O)=O MKIJZIVRJUMEAD-CUNXSJBXSA-N 0.000 claims 1
- MKIJZIVRJUMEAD-AJTFRIOCSA-N F[C@]1(CN(CC1)C[C@@H](CC(=O)O)C1=CC(=CC=C1)OCCOC)CCC1=NC=2NCCCC=2C=C1 Chemical compound F[C@]1(CN(CC1)C[C@@H](CC(=O)O)C1=CC(=CC=C1)OCCOC)CCC1=NC=2NCCCC=2C=C1 MKIJZIVRJUMEAD-AJTFRIOCSA-N 0.000 claims 1
- MKIJZIVRJUMEAD-WXVAWEFUSA-N F[C@]1(CN(CC1)C[C@H](CC(=O)O)C1=CC(=CC=C1)OCCOC)CCC1=NC=2NCCCC=2C=C1 Chemical compound F[C@]1(CN(CC1)C[C@H](CC(=O)O)C1=CC(=CC=C1)OCCOC)CCC1=NC=2NCCCC=2C=C1 MKIJZIVRJUMEAD-WXVAWEFUSA-N 0.000 claims 1
- 229960003073 Pirfenidone Drugs 0.000 claims 1
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical group C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Claims (23)
- (R)−4−((S)−3−フルオロ−3−(2−(5,6,7,8−テトラヒドロ−1,8−ナフチリジン−2−イル)エチル)ピロリジン−1−イル)−3−(3−(2−メトキシエトキシ)フェニル)ブタン酸:
(S)−4−((S)−3−フルオロ−3−(2−(5,6,7,8−テトラヒドロ−1,8−ナフチリジン−2−イル)エチル)ピロリジン−1−イル)−3−(3−(2−メトキシエトキシ)フェニル)ブタン酸:
- (S)−4−((S)−3−フルオロ−3−(2−(5,6,7,8−テトラヒドロ−1,8−ナフチリジン−2−イル)エチル)ピロリジン−1−イル)−3−(3−(2−メトキシエトキシ)フェニル)ブタン酸マレイン酸塩である、請求項1に記載の式(I)の化合物。
- 請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩と、1種以上の薬学上許容可能な担体、希釈剤または賦形剤とを含んでなる、医薬組成物。
- 経口投与用に適合させた形態である、請求項5に記載の医薬組成物。
- αvβ6受容体アンタゴニストが指示される疾患または病態の治療において使用するための、請求項5または6に記載の医薬組成物。
- 線維性疾患の治療において使用するための、請求項5または6に記載の医薬組成物。
- 線維性疾患の予防において使用するための、請求項5または6に記載の医薬組成物。
- 特発性肺線維症の治療において使用するための、請求項5または6に記載の医薬組成物。
- 特発性肺線維症の予防において使用するための、請求項5または6に記載の医薬組成物。
- ヒトにおけるαvβ6受容体の拮抗作用が有益である障害の治療のための、請求項5または6に記載の医薬組成物。
- ヒトにおけるαvβ6受容体の拮抗作用が有益である障害の予防のための、請求項5または6に記載の医薬組成物。
- 治療するための薬剤の製造における、請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩の使用。
- αvβ6受容体アンタゴニストが指示される疾患または病態を治療するための薬剤の製造における、請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩の使用。
- 線維性疾患の治療のための薬剤の製造における、請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩の使用。
- 特発性肺線維症の治療のための薬剤の製造における、請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩の使用。
- 請求項1〜4のいずれか一項に記載の式(I)の化合物またはその薬学的に許容可能な塩と、少なくとも1種の他の薬学上活性な薬剤とを含んでなる、組合せ。
- 治療において使用するための、請求項18に記載の組合せ。
- 他の薬学上活性な薬剤がTGFβ合成の阻害剤である、請求項18または19に記載の組合せ。
- 他の薬学上活性な薬剤がピルフェニドンである、請求項18または19に記載の組合せ。
- 他の薬学上活性な薬剤がニンテダニブ(BIBF−1120)である、請求項18または19に記載の組合せ。
- 他の薬学上活性な薬剤が抗αvβ6抗体である、請求項18または19に記載の組合せ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1417002.1A GB201417002D0 (en) | 2014-09-26 | 2014-09-26 | Novel compound |
GB1417002.1 | 2014-09-26 | ||
PCT/EP2015/071776 WO2016046225A1 (en) | 2014-09-26 | 2015-09-22 | Novel compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017528507A JP2017528507A (ja) | 2017-09-28 |
JP2017528507A5 true JP2017528507A5 (ja) | 2018-01-25 |
JP6611799B2 JP6611799B2 (ja) | 2019-11-27 |
Family
ID=51901158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017516387A Expired - Fee Related JP6611799B2 (ja) | 2014-09-26 | 2015-09-22 | 新規化合物 |
Country Status (36)
Country | Link |
---|---|
US (3) | US9956209B2 (ja) |
EP (2) | EP3197892B1 (ja) |
JP (1) | JP6611799B2 (ja) |
KR (1) | KR101998000B1 (ja) |
CN (1) | CN107074848B (ja) |
AR (1) | AR101994A1 (ja) |
AU (1) | AU2015320858B2 (ja) |
BR (1) | BR112017006251A2 (ja) |
CA (1) | CA2962315A1 (ja) |
CL (1) | CL2017000705A1 (ja) |
CO (1) | CO2017002714A2 (ja) |
CR (1) | CR20170112A (ja) |
CY (1) | CY1121071T1 (ja) |
DK (1) | DK3197892T3 (ja) |
DO (1) | DOP2017000081A (ja) |
EA (1) | EA031481B1 (ja) |
ES (1) | ES2690748T3 (ja) |
GB (1) | GB201417002D0 (ja) |
HR (1) | HRP20181796T1 (ja) |
HU (1) | HUE041827T2 (ja) |
IL (1) | IL250592A0 (ja) |
JO (1) | JO3413B1 (ja) |
LT (1) | LT3197892T (ja) |
MA (1) | MA40580B1 (ja) |
MX (1) | MX2017003948A (ja) |
PE (1) | PE20170502A1 (ja) |
PH (1) | PH12017500361A1 (ja) |
PL (1) | PL3197892T3 (ja) |
PT (1) | PT3197892T (ja) |
RS (1) | RS58000B1 (ja) |
SG (1) | SG11201701183YA (ja) |
SI (1) | SI3197892T1 (ja) |
TW (1) | TW201629056A (ja) |
UA (1) | UA119181C2 (ja) |
UY (1) | UY36314A (ja) |
WO (1) | WO2016046225A1 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417002D0 (en) * | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201604589D0 (en) * | 2016-03-18 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical compound |
GB201604681D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
CN110167933B (zh) | 2016-11-08 | 2022-06-21 | 百时美施贵宝公司 | 作为αV整联蛋白抑制剂的唑酰胺和胺 |
HRP20220990T1 (hr) | 2016-11-08 | 2022-11-11 | Bristol-Myers Squibb Company | 3-supstituirane propionske kiseline kao inhibitori alfa v integrina |
JP7220653B2 (ja) * | 2016-11-08 | 2023-02-10 | ブリストル-マイヤーズ スクイブ カンパニー | アルファvインテグリン阻害剤としてのピロールアミド |
JP7264810B2 (ja) | 2016-11-08 | 2023-04-25 | ブリストル-マイヤーズ スクイブ カンパニー | アルファvインテグリン阻害剤としてのシクロブタン-およびアゼチジン-含有の単環およびスピロ環式化合物 |
EA201991123A1 (ru) | 2016-11-08 | 2019-11-29 | ИНДАЗОЛОВЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ИНТЕГРИНА αV | |
EP3558303A4 (en) * | 2016-12-23 | 2020-07-29 | Pliant Therapeutics, Inc. | AMINO ACID COMPOUNDS AND METHOD FOR USE |
EP3589627A4 (en) | 2017-02-28 | 2020-08-05 | Morphic Therapeutic, Inc. | INHIBITORS OF (ALPHA-V) (BETA-6) -INTEGRIN |
US11046685B2 (en) | 2017-02-28 | 2021-06-29 | Morphic Therapeutic, Inc. | Inhibitors of (α-v)(β-6) integrin |
WO2018167295A1 (en) * | 2017-03-17 | 2018-09-20 | Technische Universität München | LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF |
EP3707142B1 (en) | 2017-11-07 | 2021-12-08 | Bristol-Myers Squibb Company | Pyrrolopyrazine derivatives as alpha v integrin inhibitors |
CN108208177A (zh) * | 2017-11-28 | 2018-06-29 | 上海交通大学医学院附属新华医院 | 含丁酸类化合物的组合物及其应用 |
EP3843727A4 (en) * | 2018-08-29 | 2022-08-17 | Morphic Therapeutic, Inc. | INTEGRIN (ALPHA-V)(BETA-6) INHIBITORS |
PE20211640A1 (es) * | 2018-08-29 | 2021-08-24 | Morphic Therapeutic Inc | INHIBICION DE LA INTEGRINA xvß6 |
WO2020047207A1 (en) * | 2018-08-29 | 2020-03-05 | Morphic Therapeutics, Inc. | Inhibitors of (alpha-v)(beta-6) integrin |
EP3844162A4 (en) * | 2018-08-29 | 2022-05-25 | Morphic Therapeutic, Inc. | INHIBITORS OF AV-BETA6 INTEGRIN |
WO2020074937A1 (en) * | 2018-10-09 | 2020-04-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of alpha-v-integrin (cd51) inhibitors for the treatment of cardiac fibrosis |
KR20210099066A (ko) * | 2018-12-04 | 2021-08-11 | 스미토모 다이니폰 파마 온콜로지, 인크. | 암의 치료를 위한 작용제로서 사용하기 위한 cdk9 억제제 및 그의 다형체 |
GB202010626D0 (en) | 2020-07-10 | 2020-08-26 | Univ Nottingham | Compound |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010033248A (ko) | 1997-12-17 | 2001-04-25 | 폴락 돈나 엘. | 인테그린 수용체 길항제 |
AU736026B2 (en) | 1997-12-17 | 2001-07-26 | Merck & Co., Inc. | Integrin receptor antagonists |
HUP0302468A2 (hu) | 1999-06-02 | 2003-11-28 | Merck & Co., Inc. | Alfa V integrin receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények |
EP1194151A4 (en) | 1999-06-23 | 2003-01-15 | Merck & Co Inc | ANTAGONISTS OF THE INTEGRIN RECEPTORS |
JP2003510360A (ja) * | 1999-10-04 | 2003-03-18 | メルク エンド カムパニー インコーポレーテッド | インテグリン受容体拮抗薬 |
DE60004087T2 (de) | 1999-11-08 | 2004-04-15 | Merck & Co., Inc. | Verfahren und zwischenprodukte zur herstellung von imidazolinon alpha v integrin antagonisten |
US6921767B2 (en) | 2000-06-15 | 2005-07-26 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives |
US6933304B2 (en) | 2000-06-15 | 2005-08-23 | Pharmacia Corporation | Heteroarylalkanoic acids as integrin receptor antagonists |
JP2004504349A (ja) | 2000-07-26 | 2004-02-12 | メルク エンド カムパニー インコーポレーテッド | αvインテグリン受容体拮抗薬 |
WO2002022616A2 (en) | 2000-09-14 | 2002-03-21 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
JP2004517853A (ja) | 2001-01-03 | 2004-06-17 | メルク エンド カムパニー インコーポレーテッド | 歯周病の治療方法及び治療用組成物 |
DE10112771A1 (de) | 2001-03-16 | 2002-09-26 | Merck Patent Gmbh | Inhibitoren des Integrins alpha¶v¶beta¶6¶ |
MY130622A (en) | 2001-11-05 | 2007-07-31 | Novartis Ag | Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors |
NZ535425A (en) | 2002-03-13 | 2008-05-30 | Biogen Idec Inc | Anti-alphavbeta6 antibodies |
US20040224986A1 (en) * | 2002-08-16 | 2004-11-11 | Bart De Corte | Piperidinyl targeting compounds that selectively bind integrins |
JP2006518333A (ja) | 2002-12-20 | 2006-08-10 | ファルマシア・コーポレーション | インテグリン受容体アンタゴニストとしてのヘテロアリールアルカン酸 |
US6932865B2 (en) | 2003-04-11 | 2005-08-23 | Lockheed Martin Corporation | System and method of making single-crystal structures through free-form fabrication techniques |
PT2139882E (pt) | 2007-03-23 | 2014-01-30 | Amgen Inc | Derivados de quinolina ou quinoxalina 3-substituídos e sua utilização como inibidores de fosfatidilinositol 3-cinase (pi3k) |
US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
EP2211615A4 (en) | 2007-10-22 | 2010-10-13 | Glaxosmithkline Llc | PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS |
WO2011111880A1 (ko) | 2010-03-08 | 2011-09-15 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 gsk3의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 gsk3 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
GB201305668D0 (en) | 2013-03-28 | 2013-05-15 | Glaxosmithkline Ip Dev Ltd | Avs6 Integrin Antagonists |
AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
GB201417011D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417002D0 (en) * | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compound |
GB201417018D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
GB201417094D0 (en) | 2014-09-26 | 2014-11-12 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
AU2016219906B2 (en) | 2015-02-19 | 2020-10-01 | Scifluor Life Sciences, Inc. | Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof |
US10214522B2 (en) | 2015-03-10 | 2019-02-26 | The Regents Of The University Of California | Anti-alphavbeta1 integrin inhibitors and methods of use |
GB201604589D0 (en) | 2016-03-18 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical compound |
GB201604680D0 (en) | 2016-03-21 | 2016-05-04 | Glaxosmithkline Ip Dev Ltd | Chemical Compounds |
-
2014
- 2014-09-26 GB GBGB1417002.1A patent/GB201417002D0/en not_active Ceased
-
2015
- 2015-09-22 WO PCT/EP2015/071776 patent/WO2016046225A1/en active Application Filing
- 2015-09-22 KR KR1020177007738A patent/KR101998000B1/ko active IP Right Grant
- 2015-09-22 SI SI201530476T patent/SI3197892T1/sl unknown
- 2015-09-22 EA EA201790715A patent/EA031481B1/ru not_active IP Right Cessation
- 2015-09-22 DK DK15767475.5T patent/DK3197892T3/en active
- 2015-09-22 JO JOP/2015/0234A patent/JO3413B1/ar active
- 2015-09-22 CA CA2962315A patent/CA2962315A1/en not_active Abandoned
- 2015-09-22 UA UAA201703900A patent/UA119181C2/uk unknown
- 2015-09-22 SG SG11201701183YA patent/SG11201701183YA/en unknown
- 2015-09-22 AR ARP150103047A patent/AR101994A1/es unknown
- 2015-09-22 PE PE2017000380A patent/PE20170502A1/es unknown
- 2015-09-22 EP EP15767475.5A patent/EP3197892B1/en active Active
- 2015-09-22 BR BR112017006251A patent/BR112017006251A2/pt not_active Application Discontinuation
- 2015-09-22 PL PL15767475T patent/PL3197892T3/pl unknown
- 2015-09-22 US US15/514,399 patent/US9956209B2/en not_active Expired - Fee Related
- 2015-09-22 CR CR20170112A patent/CR20170112A/es unknown
- 2015-09-22 PT PT15767475T patent/PT3197892T/pt unknown
- 2015-09-22 MA MA40580A patent/MA40580B1/fr unknown
- 2015-09-22 JP JP2017516387A patent/JP6611799B2/ja not_active Expired - Fee Related
- 2015-09-22 MX MX2017003948A patent/MX2017003948A/es unknown
- 2015-09-22 RS RS20181417A patent/RS58000B1/sr unknown
- 2015-09-22 UY UY0001036314A patent/UY36314A/es not_active Application Discontinuation
- 2015-09-22 TW TW104131366A patent/TW201629056A/zh unknown
- 2015-09-22 ES ES15767475.5T patent/ES2690748T3/es active Active
- 2015-09-22 CN CN201580050280.XA patent/CN107074848B/zh not_active Expired - Fee Related
- 2015-09-22 EP EP18191644.6A patent/EP3428167A1/en not_active Withdrawn
- 2015-09-22 LT LTEP15767475.5T patent/LT3197892T/lt unknown
- 2015-09-22 HU HUE15767475A patent/HUE041827T2/hu unknown
- 2015-09-22 AU AU2015320858A patent/AU2015320858B2/en not_active Ceased
-
2017
- 2017-02-14 IL IL250592A patent/IL250592A0/en unknown
- 2017-02-28 PH PH12017500361A patent/PH12017500361A1/en unknown
- 2017-03-22 CO CONC2017/0002714A patent/CO2017002714A2/es unknown
- 2017-03-23 CL CL2017000705A patent/CL2017000705A1/es unknown
- 2017-03-23 DO DO2017000081A patent/DOP2017000081A/es unknown
-
2018
- 2018-03-15 US US15/922,674 patent/US10342783B2/en not_active Expired - Fee Related
- 2018-10-30 HR HRP20181796TT patent/HRP20181796T1/hr unknown
- 2018-11-27 CY CY181101259T patent/CY1121071T1/el unknown
-
2019
- 2019-05-28 US US16/423,455 patent/US20190275016A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2017528507A5 (ja) | ||
JP2017528503A5 (ja) | ||
RU2017114346A (ru) | АНТАГОНИСТЫ ИНТЕГРИНА ανβ6 | |
RU2018136580A (ru) | Цитратная соль (s)-4-((s)-3-фтор-3-(2-(5,6,7,8-тетрагидро-1,8-нафтиридин-2-ил)этил)пирролидин-1-ил)-3-(3-(2-метоксиэтокси)фенил)бутановой кислоты | |
JP2017222722A5 (ja) | ||
JP2018021046A5 (ja) | ||
JP2009536176A5 (ja) | ||
RU2017114352A (ru) | АНТАГОНИСТЫ ИНТЕГРИНА ανβ6 | |
JP2015512406A5 (ja) | ||
JP2018513107A5 (ja) | ||
MX2014006547A (es) | Tratamiento combinado del cancer. | |
JP2014526501A5 (ja) | ||
JP2010059183A5 (ja) | ||
JP2018168191A5 (ja) | ||
JP2013543896A5 (ja) | ||
JP2017528506A5 (ja) | ||
TW200803857A (en) | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders | |
JP2015057436A5 (ja) | ||
JP2014502641A5 (ja) | ||
JP2013507415A5 (ja) | ||
JP2018537507A5 (ja) | ||
JP5643213B2 (ja) | 肥大性心筋症治療用のホスホジエステラーゼタイプIII(PDEIII)インヒビターまたはCa2+感作剤 | |
JP2020512337A5 (ja) | ||
RU2019100037A (ru) | Способ лечения рассеянного склероза с использованием ингибитора lsd1 | |
JP2013507442A5 (ja) |