JP2017526716A5 - - Google Patents

Download PDF

Info

Publication number
JP2017526716A5
JP2017526716A5 JP2017513658A JP2017513658A JP2017526716A5 JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5 JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017513658 A JP2017513658 A JP 2017513658A JP 2017526716 A5 JP2017526716 A5 JP 2017526716A5
Authority
JP
Japan
Prior art keywords
group
formula
compound
pharmaceutically acceptable
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2017513658A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017526716A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2015/070449 external-priority patent/WO2016038007A1/en
Publication of JP2017526716A publication Critical patent/JP2017526716A/ja
Publication of JP2017526716A5 publication Critical patent/JP2017526716A5/ja
Ceased legal-status Critical Current

Links

JP2017513658A 2014-09-12 2015-09-08 カテプシンｃのスピロ環状阻害剤 Ceased JP2017526716A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14184613.9 2014-09-12
EP14184613 2014-09-12
PCT/EP2015/070449 WO2016038007A1 (en) 2014-09-12 2015-09-08 Spirocyclic inhibitors of cathepsin c

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017246001A Division JP6360961B2 (ja) 2014-09-12 2017-12-22 カテプシンｃのスピロ環状阻害剤

Publications (2)

Publication Number Publication Date
JP2017526716A JP2017526716A (ja) 2017-09-14
JP2017526716A5 true JP2017526716A5 (en:Method) 2017-10-26

Family

ID=51535355

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017513658A Ceased JP2017526716A (ja) 2014-09-12 2015-09-08 カテプシンｃのスピロ環状阻害剤
JP2017246001A Active JP6360961B2 (ja) 2014-09-12 2017-12-22 カテプシンｃのスピロ環状阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017246001A Active JP6360961B2 (ja) 2014-09-12 2017-12-22 カテプシンｃのスピロ環状阻害剤

Country Status (34)

Country Link
US (3) US9540373B2 (en:Method)
EP (2) EP3511331A1 (en:Method)
JP (2) JP2017526716A (en:Method)
KR (1) KR102510588B1 (en:Method)
CN (2) CN107074870B (en:Method)
AP (1) AP2017009733A0 (en:Method)
AU (1) AU2015314355B2 (en:Method)
BR (1) BR112017003433B1 (en:Method)
CA (1) CA2960916C (en:Method)
CL (1) CL2017000432A1 (en:Method)
CO (1) CO2017002268A2 (en:Method)
CY (1) CY1123033T1 (en:Method)
DK (1) DK3191487T3 (en:Method)
EA (1) EA031376B1 (en:Method)
ES (1) ES2749009T3 (en:Method)
HK (1) HK1255362A1 (en:Method)
HR (1) HRP20191756T1 (en:Method)
HU (1) HUE047208T2 (en:Method)
IL (1) IL250262B (en:Method)
LT (1) LT3191487T (en:Method)
MX (2) MX378099B (en:Method)
MY (1) MY188382A (en:Method)
NZ (1) NZ728684A (en:Method)
PE (1) PE20170438A1 (en:Method)
PH (1) PH12017500453B1 (en:Method)
PL (1) PL3191487T3 (en:Method)
PT (1) PT3191487T (en:Method)
RS (1) RS59444B1 (en:Method)
SA (1) SA517381064B1 (en:Method)
SG (1) SG11201701633SA (en:Method)
SI (1) SI3191487T1 (en:Method)
TW (1) TWI687424B (en:Method)
UA (1) UA118610C2 (en:Method)
WO (1) WO2016038007A1 (en:Method)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011116282A2 (en) 2010-03-19 2011-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nicotinic acetylcholine receptor agonists
NO2699580T3 (en:Method) 2014-01-24 2018-02-24
JP6529575B2 (ja) * 2014-08-01 2019-06-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換オキセタンおよびそれらのカテプシンｃの阻害薬としての使用
JP2017526716A (ja) * 2014-09-12 2017-09-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃのスピロ環状阻害剤
EP4467565A3 (en) 2016-12-21 2025-03-12 Amgen Inc. Anti-tnf alpha antibody formulations
WO2018162312A1 (en) * 2017-03-10 2018-09-13 Basf Se Spirocyclic derivatives
KR20200118103A (ko) * 2018-02-07 2020-10-14 인스메드 인코포레이티드 Anca 관련 혈관염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
FI3758708T3 (fi) 2018-03-01 2025-02-18 Astrazeneca Ab (2s)-{(1s)-1-syano-2-[4-(3-metyyli-2-okso-2,3-dihydro-1,3-bentsoksatsol-5-yyli)fenyyli]etyyli}-1,4-oksatsepaani-2-karboksamidia käsittäviä farmaseuttisia koostumuksia
KR20210032431A (ko) 2018-07-17 2021-03-24 인스메드 인코포레이티드 루푸스 신염을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드
CN110256429B (zh) * 2019-06-17 2021-06-22 广东药科大学 一种具有螺环结构的氨基嘧啶类化合物及其制备方法和应用
CN110257504A (zh) * 2019-06-30 2019-09-20 中南大学 一种难治性哮喘检测标记物的筛选方法及其应用
WO2022020245A1 (en) 2020-07-20 2022-01-27 Insmed, Inc. Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions
CN114106005B (zh) * 2020-08-26 2025-08-01 西藏海思科制药有限公司 一种作为二肽基肽酶1抑制剂的腈衍生物及其用途
US20240002386A1 (en) * 2020-11-17 2024-01-04 Vertex Pharmaceuticals Incorporated Solid forms of 4-(5-(4-fluorophenyl)-6-(tetrahydro-2h-pyran-4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid
CN116157405A (zh) * 2020-12-04 2023-05-23 瑞石生物医药有限公司 组织蛋白酶c小分子抑制剂及其医药用途
CN114591315A (zh) * 2020-12-04 2022-06-07 瑞石生物医药有限公司 一种组织蛋白酶c小分子抑制剂
CN119317620A (zh) 2022-06-13 2025-01-14 亚力维克希斯股份有限公司 氮杂环烷基羰基环状胺化合物
WO2024008680A1 (en) 2022-07-06 2024-01-11 Chiesi Farmaceutici S.P.A. Azetidine derivatives and use thereof as dipeptidyl peptidase 1 inhibitors
WO2024088307A1 (zh) * 2022-10-26 2024-05-02 上海壹迪生物技术有限公司 一种新型肽基腈类化合物及其应用
JP2026503035A (ja) 2023-01-06 2026-01-27 インスメッド インコーポレイテッド 新規な可逆性ｄｐｐ１阻害剤及びその用途
WO2025214464A1 (en) * 2024-04-12 2025-10-16 Insmed Incorporated Crystalline forms of (s) -n- (1-cyano-2- (2-fluoro-4- (1' - (oxetan-3-yl) -3h-spiro [isobenzofuran-1, 4' -piperidin] -6-yl) phenyl) ethyl) -2-azabicyclo [2.2.2] octane-1-carboxamide

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4125727A (en) 1976-10-18 1978-11-14 American Cyanamid Company Method of preparing imidazoisoindolediones
GB8922355D0 (en) 1989-10-04 1989-11-22 British Telecomm Sealing gland
GEP20012487B (en) 1998-09-16 2001-07-25 Merab Lomia Use of Chemical Agent 5-carbarnoyl-5H-Dibenz (b,f) azepin, its Derivatives and Analogues by New Purpose
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
ATE409482T1 (de) 2001-03-02 2008-10-15 Merck Frosst Canada Ltd Cathepsincystein-proteasehemmer
TW200306189A (en) 2002-03-21 2003-11-16 Merz Pharma Gmbh & Co Kgaa Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists
US20070099958A1 (en) 2003-06-18 2007-05-03 Prozymex A/S Protease inhibitors
TW200528440A (en) 2003-10-31 2005-09-01 Fujisawa Pharmaceutical Co 2-cyanopyrrolidinecarboxamide compound
US20060223846A1 (en) 2005-03-08 2006-10-05 Dyatkin Alexey B Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
MX2008014800A (es) * 2006-06-01 2008-12-02 Sanofi Aventis Nitrilos espirociclicos como inhibidores de proteasa.
WO2008047544A1 (en) 2006-09-28 2008-04-24 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
WO2009047829A1 (ja) 2007-10-12 2009-04-16 Fujitsu Limited Ｉｐ電話自動試験システム及び方法
MX2010006110A (es) 2007-12-12 2010-06-25 Astrazeneca Ab Peptidil-nitrilos y usos de los mismos como inhibidores de la dipeptidil-peptidasa i.
KR20120034639A (ko) 2009-05-07 2012-04-12 아스트라제네카 아베 치환된 1-시아노에틸헤테로시클릴카르복스아미드 화합물 750
WO2010142985A1 (en) 2009-06-10 2010-12-16 Astrazeneca Ab Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
US8999975B2 (en) * 2011-09-19 2015-04-07 Boehringer Ingelheim International Gmbh Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C
MX2014012989A (es) 2012-04-27 2015-01-22 Glaxo Group Ltd Compuestos novedosos.
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
AR091112A1 (es) 2012-05-22 2015-01-14 Genentech Inc Benzamidas n-sustituidas como inhibidores de los canales de sodio nav1.7
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
TWI608013B (zh) 2012-09-17 2017-12-11 西蘭製藥公司 升糖素類似物
NZ706857A (en) 2012-09-28 2018-05-25 Ignyta Inc Azaquinazoline inhibitors of atypical protein kinase c
EP2908806A1 (en) * 2012-10-09 2015-08-26 Boehringer Ingelheim International GmbH Use of selectively moisture-adjusted tabletting material in the production of mechanically stable tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing tablets
KR102057366B1 (ko) 2012-10-15 2019-12-18 에피자임, 인코포레이티드 치환된 벤젠 화합물
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
UA117572C2 (uk) 2012-11-01 2018-08-27 Інсайт Холдинґс Корпорейшн Трициклічні конденсовані похідні тіофену як інгібітори jak
US9233974B2 (en) 2012-12-21 2016-01-12 Gilead Sciences, Inc. Antiviral compounds
SG11201504946VA (en) 2012-12-21 2015-07-30 Quanticel Pharmaceuticals Inc Histone demethylase inhibitors
SMT201800230T1 (it) 2012-12-21 2018-07-17 Plexxikon Inc Composti e metodi per la modulazione della chinasi e loro indicazioni
US9561228B2 (en) 2013-02-08 2017-02-07 Celgene Avilomics Research, Inc. ERK inhibitors and uses thereof
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US9617272B2 (en) 2013-03-14 2017-04-11 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
AR095426A1 (es) 2013-03-14 2015-10-14 Onyx Therapeutics Inc Inhibidores tripeptídicos de la epoxicetona proteasa
JO3383B1 (ar) 2013-03-14 2019-03-13 Lilly Co Eli مثبطات cdc7
MX355945B (es) 2013-03-14 2018-05-07 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
PL2970283T3 (pl) * 2013-03-14 2021-05-31 Boehringer Ingelheim International Gmbh Podstawione (benzylocyjanometylo)amidy kwasu 2-aza-bicyklo[2.2.1]heptano-3-karboksylowego będące inhibitorami katepsyny c
TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
US8877775B2 (en) * 2013-03-14 2014-11-04 Boehringer Ingelheim International Gmbh Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C
ES2675876T3 (es) * 2014-04-29 2018-07-13 Carebay Europe Ltd Dispositivo para ajustar la profundidad de inserción de aguja
WO2016003723A1 (en) 2014-07-03 2016-01-07 Bridgestone Americas Tire Operations, Llc Sidewall decoration on rim guard
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
AR101696A1 (es) 2014-09-12 2017-01-04 Lilly Co Eli Compuestos de azetidiniloxifenilpirrolidina
US10059699B2 (en) 2014-09-12 2018-08-28 Glaxosmithkline Intellectual Property (No.2) Limited Tetrahydroquinoline derivatives as bromodomain inhibitors
JP2017526716A (ja) * 2014-09-12 2017-09-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング カテプシンｃのスピロ環状阻害剤

Similar Documents

Publication Publication Date Title
JP2017526716A5 (en:Method)
JP2017522352A5 (en:Method)
JP2016516020A5 (en:Method)
JP2016510785A5 (en:Method)
JP2015521167A5 (en:Method)
HRP20191756T1 (hr) Spirociklički inhibitori katepsina c
JP2017528503A5 (en:Method)
JP2016515110A5 (en:Method)
JP2017528507A5 (en:Method)
JP2016510784A5 (en:Method)
JP2015524807A5 (en:Method)
JP2019529541A5 (en:Method)
CN110769824B (zh) 用于治疗和/或预防细菌继发性感染的il-8抑制剂
CN102655859A (zh) 病毒感染的组合疗法治疗
JP2015051983A5 (en:Method)
JP2011507879A5 (en:Method)
JP2013500977A5 (en:Method)
JP2017522300A5 (en:Method)
RU2019111421A (ru) Способы лечения острого повреждения почек
JP2017522350A5 (en:Method)
JP2019533660A5 (en:Method)
KR20180074654A (ko) 바이러스 감염의 치료를 위한 조성물 및 방법
RU2011147186A (ru) 2, 5-дизамещенные арилсульфонамидные антагонисты ссr3
JP2020500868A5 (en:Method)
JP2017522349A5 (en:Method)