JP2017526706A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017526706A5 JP2017526706A5 JP2017513199A JP2017513199A JP2017526706A5 JP 2017526706 A5 JP2017526706 A5 JP 2017526706A5 JP 2017513199 A JP2017513199 A JP 2017513199A JP 2017513199 A JP2017513199 A JP 2017513199A JP 2017526706 A5 JP2017526706 A5 JP 2017526706A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- tumor
- cell
- lymphoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 128
- 206010028980 Neoplasm Diseases 0.000 claims 56
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 36
- 125000003282 alkyl amino group Chemical group 0.000 claims 29
- 125000004663 dialkyl amino group Chemical group 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 29
- 239000001257 hydrogen Substances 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 19
- 201000011510 cancer Diseases 0.000 claims 18
- 125000003118 aryl group Chemical group 0.000 claims 17
- 150000002431 hydrogen Chemical class 0.000 claims 15
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 9
- 201000001441 melanoma Diseases 0.000 claims 9
- 201000005962 mycosis fungoides Diseases 0.000 claims 9
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 9
- 208000032612 Glial tumor Diseases 0.000 claims 8
- 206010018338 Glioma Diseases 0.000 claims 8
- 206010042971 T-cell lymphoma Diseases 0.000 claims 8
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 230000003211 malignant effect Effects 0.000 claims 8
- 206010025323 Lymphomas Diseases 0.000 claims 7
- 206010039491 Sarcoma Diseases 0.000 claims 7
- 201000000053 blastoma Diseases 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 201000008184 embryoma Diseases 0.000 claims 7
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 6
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 6
- 208000003200 Adenoma Diseases 0.000 claims 6
- 206010001233 Adenoma benign Diseases 0.000 claims 6
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 6
- 201000009030 Carcinoma Diseases 0.000 claims 6
- 208000021309 Germ cell tumor Diseases 0.000 claims 6
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 6
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 6
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 6
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 6
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 6
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 6
- 208000000260 Warts Diseases 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 206010016629 fibroma Diseases 0.000 claims 6
- 206010017758 gastric cancer Diseases 0.000 claims 6
- 201000002222 hemangioblastoma Diseases 0.000 claims 6
- 208000032839 leukemia Diseases 0.000 claims 6
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 6
- 201000010153 skin papilloma Diseases 0.000 claims 6
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 6
- 201000011549 stomach cancer Diseases 0.000 claims 6
- 206010003571 Astrocytoma Diseases 0.000 claims 5
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 5
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 5
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 5
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 5
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 5
- 125000004476 heterocycloamino group Chemical group 0.000 claims 5
- 125000005191 hydroxyalkylamino group Chemical group 0.000 claims 5
- 201000008968 osteosarcoma Diseases 0.000 claims 5
- 201000002510 thyroid cancer Diseases 0.000 claims 5
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims 4
- 208000003950 B-cell lymphoma Diseases 0.000 claims 4
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 201000002313 intestinal cancer Diseases 0.000 claims 4
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 4
- 206010027191 meningioma Diseases 0.000 claims 4
- 230000001817 pituitary effect Effects 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 3
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 3
- 241000321096 Adenoides Species 0.000 claims 3
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims 3
- 208000037540 Alveolar soft tissue sarcoma Diseases 0.000 claims 3
- 201000003076 Angiosarcoma Diseases 0.000 claims 3
- 201000008271 Atypical teratoid rhabdoid tumor Diseases 0.000 claims 3
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000019838 Blood disease Diseases 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 3
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 3
- 201000000274 Carcinosarcoma Diseases 0.000 claims 3
- 208000007389 Cementoma Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 206010008583 Chloroma Diseases 0.000 claims 3
- 201000005262 Chondroma Diseases 0.000 claims 3
- 201000009047 Chordoma Diseases 0.000 claims 3
- 208000004378 Choroid plexus papilloma Diseases 0.000 claims 3
- 206010009253 Clear cell sarcoma of the kidney Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000009798 Craniopharyngioma Diseases 0.000 claims 3
- 208000008334 Dermatofibrosarcoma Diseases 0.000 claims 3
- 201000009051 Embryonal Carcinoma Diseases 0.000 claims 3
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 3
- 208000033832 Eosinophilic Acute Leukemia Diseases 0.000 claims 3
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 3
- 208000036566 Erythroleukaemia Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims 3
- 201000008808 Fibrosarcoma Diseases 0.000 claims 3
- 206010016654 Fibrosis Diseases 0.000 claims 3
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 3
- 208000003098 Ganglion Cysts Diseases 0.000 claims 3
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 3
- 206010018404 Glucagonoma Diseases 0.000 claims 3
- 208000005234 Granulosa Cell Tumor Diseases 0.000 claims 3
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims 3
- 206010023825 Laryngeal cancer Diseases 0.000 claims 3
- 201000004462 Leydig Cell Tumor Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010025219 Lymphangioma Diseases 0.000 claims 3
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 3
- 201000003791 MALT lymphoma Diseases 0.000 claims 3
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 3
- 208000000172 Medulloblastoma Diseases 0.000 claims 3
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 3
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 3
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 206010073137 Myxoid liposarcoma Diseases 0.000 claims 3
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 3
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 3
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 3
- 201000004404 Neurofibroma Diseases 0.000 claims 3
- 208000005890 Neuroma Diseases 0.000 claims 3
- 206010029488 Nodular melanoma Diseases 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 206010061872 Non-renal cell carcinoma of kidney Diseases 0.000 claims 3
- 208000007871 Odontogenic Tumors Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 201000010630 Pancoast tumor Diseases 0.000 claims 3
- 208000015330 Pancoast tumour Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 3
- 208000037064 Papilloma of choroid plexus Diseases 0.000 claims 3
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 3
- 208000031839 Peripheral nerve sheath tumour malignant Diseases 0.000 claims 3
- 201000005746 Pituitary adenoma Diseases 0.000 claims 3
- 206010061538 Pituitary tumour benign Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 208000007452 Plasmacytoma Diseases 0.000 claims 3
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 208000034541 Rare lymphatic malformation Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000033889 Renal medullary carcinoma Diseases 0.000 claims 3
- 201000000582 Retinoblastoma Diseases 0.000 claims 3
- 208000025316 Richter syndrome Diseases 0.000 claims 3
- 201000010208 Seminoma Diseases 0.000 claims 3
- 208000003274 Sertoli cell tumor Diseases 0.000 claims 3
- 208000009359 Sezary Syndrome Diseases 0.000 claims 3
- 208000021388 Sezary disease Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 206010041067 Small cell lung cancer Diseases 0.000 claims 3
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 3
- 208000005400 Synovial Cyst Diseases 0.000 claims 3
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 3
- 208000020982 T-lymphoblastic lymphoma Diseases 0.000 claims 3
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 3
- 206010057644 Testis cancer Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000008385 Urogenital Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 3
- 201000005969 Uveal melanoma Diseases 0.000 claims 3
- 208000014070 Vestibular schwannoma Diseases 0.000 claims 3
- 206010047741 Vulval cancer Diseases 0.000 claims 3
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 3
- 208000008383 Wilms tumor Diseases 0.000 claims 3
- 208000005310 acidophil adenoma Diseases 0.000 claims 3
- 208000006336 acinar cell carcinoma Diseases 0.000 claims 3
- 208000004064 acoustic neuroma Diseases 0.000 claims 3
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 3
- 208000009956 adenocarcinoma Diseases 0.000 claims 3
- 210000002534 adenoid Anatomy 0.000 claims 3
- 208000002517 adenoid cystic carcinoma Diseases 0.000 claims 3
- 201000008395 adenosquamous carcinoma Diseases 0.000 claims 3
- 208000020990 adrenal cortex carcinoma Diseases 0.000 claims 3
- 201000005188 adrenal gland cancer Diseases 0.000 claims 3
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 3
- 208000007128 adrenocortical carcinoma Diseases 0.000 claims 3
- 201000006966 adult T-cell leukemia Diseases 0.000 claims 3
- 208000015230 aggressive NK-cell leukemia Diseases 0.000 claims 3
- 206010065867 alveolar rhabdomyosarcoma Diseases 0.000 claims 3
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 3
- 201000009036 biliary tract cancer Diseases 0.000 claims 3
- 208000020790 biliary tract neoplasm Diseases 0.000 claims 3
- 201000011143 bone giant cell tumor Diseases 0.000 claims 3
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000030748 clear cell sarcoma of kidney Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 3
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 3
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 3
- 210000003298 dental enamel Anatomy 0.000 claims 3
- 210000001900 endoderm Anatomy 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 208000024519 eye neoplasm Diseases 0.000 claims 3
- 210000003754 fetus Anatomy 0.000 claims 3
- 230000004761 fibrosis Effects 0.000 claims 3
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 3
- 230000003325 follicular Effects 0.000 claims 3
- 201000003444 follicular lymphoma Diseases 0.000 claims 3
- 201000010175 gallbladder cancer Diseases 0.000 claims 3
- 201000008822 gestational choriocarcinoma Diseases 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 210000002149 gonad Anatomy 0.000 claims 3
- 230000002710 gonadal effect Effects 0.000 claims 3
- 201000009277 hairy cell leukemia Diseases 0.000 claims 3
- 201000010536 head and neck cancer Diseases 0.000 claims 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims 3
- 208000014951 hematologic disease Diseases 0.000 claims 3
- 208000018706 hematopoietic system disease Diseases 0.000 claims 3
- 208000006359 hepatoblastoma Diseases 0.000 claims 3
- 206010066957 hepatosplenic T-cell lymphoma Diseases 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 201000004933 in situ carcinoma Diseases 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 208000020319 kidney medullary carcinoma Diseases 0.000 claims 3
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 3
- 231100000518 lethal Toxicity 0.000 claims 3
- 230000001665 lethal effect Effects 0.000 claims 3
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 3
- 206010024627 liposarcoma Diseases 0.000 claims 3
- 201000007270 liver cancer Diseases 0.000 claims 3
- 208000014018 liver neoplasm Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000012804 lymphangiosarcoma Diseases 0.000 claims 3
- 230000036244 malformation Effects 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000009020 malignant peripheral nerve sheath tumor Diseases 0.000 claims 3
- 208000015179 malignant superior sulcus neoplasm Diseases 0.000 claims 3
- 201000001117 malignant triton tumor Diseases 0.000 claims 3
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 3
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 3
- 208000000516 mast-cell leukemia Diseases 0.000 claims 3
- 208000029586 mediastinal germ cell tumor Diseases 0.000 claims 3
- 230000001394 metastastic effect Effects 0.000 claims 3
- 206010061289 metastatic neoplasm Diseases 0.000 claims 3
- 201000010225 mixed cell type cancer Diseases 0.000 claims 3
- 208000029638 mixed neoplasm Diseases 0.000 claims 3
- 210000003205 muscle Anatomy 0.000 claims 3
- 201000005987 myeloid sarcoma Diseases 0.000 claims 3
- 208000009091 myxoma Diseases 0.000 claims 3
- 208000014761 nasopharyngeal type undifferentiated carcinoma Diseases 0.000 claims 3
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 3
- 201000008026 nephroblastoma Diseases 0.000 claims 3
- 208000027831 neuroepithelial neoplasm Diseases 0.000 claims 3
- 208000029974 neurofibrosarcoma Diseases 0.000 claims 3
- 201000000032 nodular malignant melanoma Diseases 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 201000008106 ocular cancer Diseases 0.000 claims 3
- 208000027825 odontogenic neoplasm Diseases 0.000 claims 3
- 208000027500 optic nerve neoplasm Diseases 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 208000007312 paraganglioma Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000021310 pituitary gland adenoma Diseases 0.000 claims 3
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 3
- 201000006845 reticulosarcoma Diseases 0.000 claims 3
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims 3
- 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 claims 3
- 210000004116 schwann cell Anatomy 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 208000000649 small cell carcinoma Diseases 0.000 claims 3
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 3
- 201000002314 small intestine cancer Diseases 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010062261 spinal cord neoplasm Diseases 0.000 claims 3
- 206010062113 splenic marginal zone lymphoma Diseases 0.000 claims 3
- 206010042863 synovial sarcoma Diseases 0.000 claims 3
- 201000003120 testicular cancer Diseases 0.000 claims 3
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 3
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 3
- 201000007363 trachea carcinoma Diseases 0.000 claims 3
- 208000025443 tumor of adipose tissue Diseases 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 206010046766 uterine cancer Diseases 0.000 claims 3
- 206010046885 vaginal cancer Diseases 0.000 claims 3
- 208000013139 vaginal neoplasm Diseases 0.000 claims 3
- 201000005102 vulva cancer Diseases 0.000 claims 3
- 206010051810 Angiomyolipoma Diseases 0.000 claims 2
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims 2
- 206010005969 Bone giant cell tumour Diseases 0.000 claims 2
- 208000007690 Brenner tumor Diseases 0.000 claims 2
- 206010073258 Brenner tumour Diseases 0.000 claims 2
- 206010053717 Fibrous histiocytoma Diseases 0.000 claims 2
- 206010016935 Follicular thyroid cancer Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 208000037196 Medullary thyroid carcinoma Diseases 0.000 claims 2
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 2
- 206010027406 Mesothelioma Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims 2
- 206010073338 Optic glioma Diseases 0.000 claims 2
- 206010050487 Pinealoblastoma Diseases 0.000 claims 2
- 208000007641 Pinealoma Diseases 0.000 claims 2
- 206010065857 Primary Effusion Lymphoma Diseases 0.000 claims 2
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 2
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000003252 Signet Ring Cell Carcinoma Diseases 0.000 claims 2
- 206010041329 Somatostatinoma Diseases 0.000 claims 2
- 201000011648 T-cell childhood lymphoblastic lymphoma Diseases 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 2
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 2
- 125000005466 alkylenyl group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 230000002490 cerebral effect Effects 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 208000037902 enteropathy Diseases 0.000 claims 2
- 230000003352 fibrogenic effect Effects 0.000 claims 2
- 201000000284 histiocytoma Diseases 0.000 claims 2
- -1 hydroxy, amino Chemical group 0.000 claims 2
- 208000030163 medullary breast carcinoma Diseases 0.000 claims 2
- 208000022669 mucinous neoplasm Diseases 0.000 claims 2
- 210000003097 mucus Anatomy 0.000 claims 2
- 208000001611 myxosarcoma Diseases 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 208000007538 neurilemmoma Diseases 0.000 claims 2
- 210000004248 oligodendroglia Anatomy 0.000 claims 2
- 210000001328 optic nerve Anatomy 0.000 claims 2
- 208000008511 optic nerve glioma Diseases 0.000 claims 2
- 201000003113 pineoblastoma Diseases 0.000 claims 2
- 208000010916 pituitary tumor Diseases 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 206010039667 schwannoma Diseases 0.000 claims 2
- 201000008123 signet ring cell adenocarcinoma Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- 208000013818 thyroid gland medullary carcinoma Diseases 0.000 claims 2
- 208000023747 urothelial carcinoma Diseases 0.000 claims 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 208000001446 Anaplastic Thyroid Carcinoma Diseases 0.000 claims 1
- 206010002240 Anaplastic thyroid cancer Diseases 0.000 claims 1
- 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000004463 Follicular Adenocarcinoma Diseases 0.000 claims 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims 1
- 201000005409 Gliomatosis cerebri Diseases 0.000 claims 1
- 208000008454 Hyperhidrosis Diseases 0.000 claims 1
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 1
- 208000007054 Medullary Carcinoma Diseases 0.000 claims 1
- 208000009018 Medullary thyroid cancer Diseases 0.000 claims 1
- 206010054837 Myolipoma Diseases 0.000 claims 1
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 206010002449 angioimmunoblastic T-cell lymphoma Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 206010006007 bone sarcoma Diseases 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000005518 carboxamido group Chemical group 0.000 claims 1
- 210000004720 cerebrum Anatomy 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014616 embryonal neoplasm Diseases 0.000 claims 1
- 210000000416 exudates and transudate Anatomy 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 210000003292 kidney cell Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000001161 mammalian embryo Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000005074 megakaryoblast Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 201000011130 optic nerve sheath meningioma Diseases 0.000 claims 1
- 208000022982 optic pathway glioma Diseases 0.000 claims 1
- 210000004303 peritoneum Anatomy 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 208000013460 sweaty Diseases 0.000 claims 1
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 0 CC(CCCC(**)*(C)C*C1)CC1NC(c1n[o]c(*)c1*)=O Chemical compound CC(CCCC(**)*(C)C*C1)CC1NC(c1n[o]c(*)c1*)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048759P | 2014-09-10 | 2014-09-10 | |
| US62/048,759 | 2014-09-10 | ||
| US201562146794P | 2015-04-13 | 2015-04-13 | |
| US62/146,794 | 2015-04-13 | ||
| PCT/US2015/049213 WO2016040498A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017526706A JP2017526706A (ja) | 2017-09-14 |
| JP2017526706A5 true JP2017526706A5 (enExample) | 2018-10-18 |
Family
ID=55459522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017513199A Pending JP2017526706A (ja) | 2014-09-10 | 2015-09-09 | イソオキサゾールカルボキサミド化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10428029B2 (enExample) |
| EP (1) | EP3193603A4 (enExample) |
| JP (1) | JP2017526706A (enExample) |
| AU (1) | AU2015315167A1 (enExample) |
| CA (1) | CA2960274A1 (enExample) |
| WO (1) | WO2016040498A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017004589A2 (pt) | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| AU2015315174B2 (en) | 2014-09-10 | 2019-12-12 | Epizyme, Inc. | Smyd inhibitors |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| EP3190891B1 (en) | 2014-09-10 | 2020-01-15 | Epizyme, Inc. | Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors |
| WO2016204006A1 (ja) | 2015-06-17 | 2016-12-22 | 住友化学株式会社 | 有害節足動物防除剤 |
| CR20210148A (es) * | 2018-09-21 | 2021-05-18 | Novartis Ag | Compuestos de isoxazol carboxamida y usos de los mismos |
| CN109879868B (zh) * | 2019-03-07 | 2022-04-22 | 南通大学 | 含2-芳基噁唑结构的吡唑酰胺类化合物的制备和应用 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065225A (en) * | 1960-02-05 | 1962-11-20 | Hoffmann La Roche | N', n4-di-isoxazolylcarbonyl-sulfanilamide derivatives |
| DE19930075A1 (de) * | 1999-06-30 | 2001-01-04 | Bayer Ag | Neue Amino- und Amidosulfonamide als antivirale Mittel |
| GB0017518D0 (en) * | 2000-07-17 | 2000-08-30 | Merck Sharp & Dohme | Therapeutic agents |
| EP1390034A4 (en) * | 2001-04-03 | 2005-07-13 | Merck & Co Inc | N-SUBSTITUTED NONARYL HETEROCYCLO AMIDYL-NMDA / NR2B ANTAGONISTS |
| CA2449249A1 (en) * | 2001-06-12 | 2002-12-19 | Merck & Co., Inc. | Nr2b receptor antagonists for the treatment or prevention of migraines |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2005004810A2 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Arylsulfonamide derivatives |
| US7709645B2 (en) * | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| TW200634003A (en) * | 2004-12-22 | 2006-10-01 | Astrazeneca Ab | Chemical compounds |
| US7291743B2 (en) * | 2005-03-29 | 2007-11-06 | Geneblue Corporation | Isoxazole derivatives and methods of treating nitric oxide mediated diseases |
| NL2000284C2 (nl) | 2005-11-04 | 2007-09-28 | Pfizer Ltd | Pyrazine-derivaten. |
| CN101563082A (zh) * | 2006-09-05 | 2009-10-21 | 窦德献 | 治疗免疫介导性皮肤病的组合物和方法 |
| EA015952B1 (ru) * | 2007-05-03 | 2011-12-30 | Пфайзер Лимитед | 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов |
| WO2008137834A2 (en) | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| EP2528925B1 (en) * | 2010-01-29 | 2017-07-05 | Hanmi Science Co., Ltd. | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY ON PROTEIN KINASES |
| WO2013043826A1 (en) * | 2011-09-21 | 2013-03-28 | Abbvie Inc. | Tricyclic compounds useful as protein kinase inhibitors |
| CA2895509C (en) * | 2012-12-18 | 2021-08-17 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
| JP2016512825A (ja) * | 2013-03-15 | 2016-05-09 | シファ・バイオメディカル・コーポレイションＳｈｉｆａ Ｂｉｏｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 抗プロタンパク質転換酵素サブチリシン／ケキシン９型（抗ｐｃｓｋ９）化合物および心血管疾患の治療および／または予防におけるその使用方法 |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| EP3190891B1 (en) | 2014-09-10 | 2020-01-15 | Epizyme, Inc. | Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors |
| JP2017527577A (ja) * | 2014-09-10 | 2017-09-21 | エピザイム，インコーポレイティド | 置換ピロリジン化合物 |
| AU2015315174B2 (en) | 2014-09-10 | 2019-12-12 | Epizyme, Inc. | Smyd inhibitors |
| BR112017004589A2 (pt) | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| EP3193609A4 (en) | 2014-09-10 | 2018-02-28 | Epizyme, Inc. | Substituted pyrrolidine carboxamide compounds |
-
2015
- 2015-09-09 CA CA2960274A patent/CA2960274A1/en not_active Abandoned
- 2015-09-09 AU AU2015315167A patent/AU2015315167A1/en not_active Abandoned
- 2015-09-09 WO PCT/US2015/049213 patent/WO2016040498A1/en not_active Ceased
- 2015-09-09 JP JP2017513199A patent/JP2017526706A/ja active Pending
- 2015-09-09 US US15/510,593 patent/US10428029B2/en active Active
- 2015-09-09 EP EP15839331.4A patent/EP3193603A4/en not_active Withdrawn
-
2019
- 2019-09-30 US US16/588,209 patent/US20200148650A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017528464A5 (enExample) | ||
| JP2016514695A5 (enExample) | ||
| JP2017527577A5 (enExample) | ||
| JP2017528460A5 (enExample) | ||
| JP2017538659A5 (enExample) | ||
| JP2019514950A5 (enExample) | ||
| CN106660974A (zh) | 含氨磺酰基的1,2,5‑噁二唑类衍生物、其制备方法及其在医药上的应用 | |
| JP2017527576A5 (enExample) | ||
| RU2014112345A (ru) | Хинолил-содержащее соединение гидроксамовой кислоты, способ его получения, фармацевтическая композиция, содержащая это соединение, и его применение | |
| JP2020515571A5 (enExample) | ||
| JP2017510641A5 (enExample) | ||
| CY1118730T1 (el) | Παραγωγα πυριδινης ως αναστολεις της αναδιαταχθεισας κατα την διαρκεια διαλοιμωξης (ret) κινασης | |
| JP2013064024A5 (enExample) | ||
| IL272697B2 (en) | A polymorphic form of TG02 | |
| NZ595602A (en) | Anti-cancer drugs, and uses relating for malignant melanoma and other cancers | |
| RU2014101626A (ru) | Полиморфы 2-амид 1-({4-метил-5-[2-(2, 2, 2-трифтор-1, 1-диметил-этил)-пиридин-4-ил]тиазол-2-ил}амида) (s)-пирролидин-1, 2-дикарбоновой кислоты | |
| JP2017528461A5 (enExample) | ||
| CN1791396A (zh) | 组蛋白脱乙酰基酶抑制剂与化疗剂的组合 | |
| JP2020506884A5 (enExample) | ||
| JP2013528215A5 (enExample) | ||
| RU2017124371A (ru) | Комбинация производного 6-оксо-1,6-дигидро-пиридазина, обладающего противораковой активностью, с производным хиназолина | |
| JP2016106092A (ja) | 組合せ | |
| HK1259409A1 (zh) | 酪蛋白激酶1δ在乳腺癌中的治疗靶向 | |
| TN2010000139A1 (en) | Organic compounds | |
| JP2023515687A5 (enExample) |