JP2017525757A5 - - Google Patents
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- Publication number
- JP2017525757A5 JP2017525757A5 JP2017522462A JP2017522462A JP2017525757A5 JP 2017525757 A5 JP2017525757 A5 JP 2017525757A5 JP 2017522462 A JP2017522462 A JP 2017522462A JP 2017522462 A JP2017522462 A JP 2017522462A JP 2017525757 A5 JP2017525757 A5 JP 2017525757A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxoisoindoline
- dioxopiperidin
- difluoro
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 O=C(C(C1=CC=*=CC=C1)(F)F)NCc(cc1CN2C(C=CC(N3)=O)C3=O)ccc1C2=O Chemical compound O=C(C(C1=CC=*=CC=C1)(F)F)NCc(cc1CN2C(C=CC(N3)=O)C3=O)ccc1C2=O 0.000 description 3
- NYVGCNSACSJVJQ-UHFFFAOYSA-N N#Cc(cc1CN2C(CCC(N3)=O)C3=O)ccc1C2=O Chemical compound N#Cc(cc1CN2C(CCC(N3)=O)C3=O)ccc1C2=O NYVGCNSACSJVJQ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462023775P | 2014-07-11 | 2014-07-11 | |
| US62/023,775 | 2014-07-11 | ||
| PCT/US2015/039926 WO2016007848A1 (en) | 2014-07-11 | 2015-07-10 | Antiproliferative compounds and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173475A Division JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525757A JP2017525757A (ja) | 2017-09-07 |
| JP2017525757A5 true JP2017525757A5 (en:Method) | 2018-08-23 |
| JP6779870B2 JP6779870B2 (ja) | 2020-11-04 |
Family
ID=53682892
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017522462A Active JP6779870B2 (ja) | 2014-07-11 | 2015-07-10 | 抗増殖性化合物及びその使用方法 |
| JP2020173475A Pending JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
| JP2022171356A Pending JP2023011732A (ja) | 2014-07-11 | 2022-10-26 | 抗増殖性化合物及びその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020173475A Pending JP2021011495A (ja) | 2014-07-11 | 2020-10-14 | 抗増殖性化合物及びその使用方法 |
| JP2022171356A Pending JP2023011732A (ja) | 2014-07-11 | 2022-10-26 | 抗増殖性化合物及びその使用方法 |
Country Status (31)
| Country | Link |
|---|---|
| US (6) | US9499514B2 (en:Method) |
| EP (2) | EP3166937B1 (en:Method) |
| JP (3) | JP6779870B2 (en:Method) |
| KR (1) | KR102477960B1 (en:Method) |
| CN (2) | CN106660991B (en:Method) |
| AR (1) | AR101189A1 (en:Method) |
| AU (1) | AU2015287688B2 (en:Method) |
| BR (1) | BR112017000550B1 (en:Method) |
| CA (1) | CA2954784C (en:Method) |
| CL (1) | CL2017000075A1 (en:Method) |
| CO (1) | CO2017000223A2 (en:Method) |
| CY (1) | CY1122340T1 (en:Method) |
| DK (1) | DK3166937T3 (en:Method) |
| EA (1) | EA033633B1 (en:Method) |
| EC (1) | ECSP17002135A (en:Method) |
| ES (2) | ES2968308T3 (en:Method) |
| HR (1) | HRP20191821T1 (en:Method) |
| HU (1) | HUE046000T2 (en:Method) |
| IL (2) | IL276946B (en:Method) |
| LT (1) | LT3166937T (en:Method) |
| MX (2) | MX373935B (en:Method) |
| PL (1) | PL3166937T3 (en:Method) |
| PT (1) | PT3166937T (en:Method) |
| RS (1) | RS59619B1 (en:Method) |
| SA (1) | SA517380693B1 (en:Method) |
| SG (2) | SG11201700126RA (en:Method) |
| SI (1) | SI3166937T1 (en:Method) |
| SM (1) | SMT201900686T1 (en:Method) |
| TW (1) | TWI660952B (en:Method) |
| WO (1) | WO2016007848A1 (en:Method) |
| ZA (1) | ZA201700217B (en:Method) |
Families Citing this family (44)
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| TWI721959B (zh) | 2014-12-04 | 2021-03-21 | 美商健生生物科技公司 | 治療急性骨髓性白血病之抗ｃｄ３８抗體 |
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| PE20181323A1 (es) | 2015-06-22 | 2018-08-14 | Janssen Biotech Inc | Terapias de combinacion para enfermedades malignas hematologicas con anticuerpos anti-cd38 e inhibidores de survivina |
| US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
| BR112018008901A8 (pt) | 2015-11-03 | 2019-02-26 | Janssen Biotech Inc | formulações subcutâneas de anticorpos anti-cd 38 e seus usos |
| US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
| EP3808346B1 (en) * | 2016-01-08 | 2023-07-19 | Celgene Corporation | Antiproliferative compounds for use in the treatment of leukemia |
| AR107320A1 (es) | 2016-01-08 | 2018-04-18 | Celgene Corp | Formas sólidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoindolin-5-il)metil)-2,2-difluoroacetamida y sus composiciones farmacéuticas y usos |
| WO2017120446A1 (en) * | 2016-01-08 | 2017-07-13 | Celgene Corporation | Methods for treating cancer and the use of biomarkers as a predictor of clinical sensitivity to therapies |
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| BR112018075206A2 (pt) | 2016-06-06 | 2019-03-19 | Celgene Corporation | tratamento de malignidade hematológica com 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida |
| US20190233533A1 (en) | 2016-06-28 | 2019-08-01 | Umc Utrecht Holding B.V. | Treatment Of IgE-Mediated Diseases With Antibodies That Specifically Bind CD38 |
| US11535603B1 (en) | 2016-09-30 | 2022-12-27 | Deuterx, Llc | Deuterium-enriched piperidinonyl-oxoisoindolinyl acetamides and methods of treating medical disorders using same |
| CN106928253A (zh) * | 2017-03-09 | 2017-07-07 | 武汉工程大学 | 一种唑啉草酯的制备方法 |
| CN111032043A (zh) * | 2017-06-30 | 2020-04-17 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合物和使用方法 |
| MA50514A (fr) | 2017-10-31 | 2020-09-09 | Janssen Biotech Inc | Méthodes de traitement du myélome multiple à haut risque |
| CN107827721B (zh) * | 2017-11-17 | 2021-03-16 | 上海恩氟佳科技有限公司 | 一种合成4-氟环己酮的方法 |
| CN111542321A (zh) * | 2018-01-02 | 2020-08-14 | 细胞基因公司 | 2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的同位素体 |
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| CN114761004A (zh) * | 2019-12-06 | 2022-07-15 | 细胞基因公司 | 用于制备2-(4-氯苯基)-n-((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2，2-二氟乙酰胺的方法 |
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| JP2024504932A (ja) | 2021-01-13 | 2024-02-02 | モンテ ローザ セラピューティクス， インコーポレイテッド | イソインドリノン化合物 |
| JP2024517808A (ja) * | 2021-05-06 | 2024-04-23 | セルジーン コーポレーション | Ｎ－（（ｒ）－１－（３－クロロピリジン－２－イル）－２，２，２－トリフルオロエチル）－２－（（ｓ）－２，６－ジオキソピペリジン－３－イル）－１－オキソイソインドリン－５－カルボキサミドによる治療方法 |
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| CN117320550A (zh) * | 2021-05-19 | 2023-12-29 | 先正达农作物保护股份公司 | 杂草控制方法 |
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| ES2559388T3 (es) | 2008-10-29 | 2016-02-11 | Celgene Corporation | Compuestos de isoindolina para uso en el tratamiento del cáncer |
| US9499514B2 (en) * | 2014-07-11 | 2016-11-22 | Celgene Corporation | Antiproliferative compounds and methods of use thereof |
| AR107320A1 (es) | 2016-01-08 | 2018-04-18 | Celgene Corp | Formas sólidas de 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoindolin-5-il)metil)-2,2-difluoroacetamida y sus composiciones farmacéuticas y usos |
| EP3808346B1 (en) | 2016-01-08 | 2023-07-19 | Celgene Corporation | Antiproliferative compounds for use in the treatment of leukemia |
| CA3010797C (en) | 2016-01-08 | 2024-01-02 | Celgene Corporation | Formulations of 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide |
| BR112018075206A2 (pt) | 2016-06-06 | 2019-03-19 | Celgene Corporation | tratamento de malignidade hematológica com 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida |
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