|
FR1525186A
(fr)
|
1967-03-29 |
1968-05-17 |
Roussel Uclaf |
Nouvelles pénicillines et procédé de préparation
|
|
DE4034829A1
(de)
|
1990-11-02 |
1992-05-07 |
Merck Patent Gmbh |
Cyclopeptide
|
|
JP3190431B2
(ja)
|
1991-07-01 |
2001-07-23 |
三菱化学株式会社 |
ケトン誘導体
|
|
GB9206757D0
(en)
|
1992-03-27 |
1992-05-13 |
Ferring Bv |
Novel peptide receptor ligands
|
|
WO1996034010A2
(en)
|
1995-03-29 |
1996-10-31 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5624936A
(en)
|
1995-03-29 |
1997-04-29 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
WO1997036891A1
(en)
|
1996-04-03 |
1997-10-09 |
Merk & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5869682A
(en)
|
1996-04-03 |
1999-02-09 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
TW557297B
(en)
|
1997-09-26 |
2003-10-11 |
Abbott Lab |
Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
|
|
EP1064298B1
(en)
|
1998-03-19 |
2008-10-08 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of caspases
|
|
DE69939168D1
(de)
|
1998-05-26 |
2008-09-04 |
Warner Lambert Co |
Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
|
|
US6307049B1
(en)
|
1998-09-30 |
2001-10-23 |
The Procter & Gamble Co. |
Heterocyclic 2-substituted ketoamides
|
|
EP1016663A1
(en)
|
1999-01-02 |
2000-07-05 |
Aventis Pharma Deutschland GmbH |
Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
|
|
JP2002534420A
(ja)
|
1999-01-02 |
2002-10-15 |
アベンティス・ファーマ・ドイチユラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
新規なマロン酸誘導体、その調製方法、その使用およびそれを含有する医薬組成物（Ｘａ因子活性阻害）
|
|
SK14232001A3
(sk)
|
1999-04-09 |
2002-06-04 |
Basf Aktiengesellschaft |
Nízkomolekulové inhibítory komplementárnych proteáz
|
|
EP1125925A1
(en)
|
2000-02-15 |
2001-08-22 |
Applied Research Systems ARS Holding N.V. |
Amine derivatives for the treatment of apoptosis
|
|
ES2252230T3
(es)
|
2000-05-11 |
2006-05-16 |
Bristol-Myers Squibb Company |
Analogos de tetrahidroisoquinolina utiles como secretores de la hormona del crecimiento.
|
|
SV2003000617A
(es)
|
2000-08-31 |
2003-01-13 |
Lilly Co Eli |
Inhibidores de la proteasa peptidomimetica ref. x-14912m
|
|
WO2003011222A2
(en)
|
2001-07-27 |
2003-02-13 |
Merck & Co., Inc. |
Thrombin inhibitors
|
|
US6951840B2
(en)
|
2001-08-31 |
2005-10-04 |
Eli Lilly And Company |
Lipoglycopeptide antibiotics
|
|
US6649606B1
(en)
|
2001-11-09 |
2003-11-18 |
Bristol-Myers Squibb Co. |
Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
|
|
WO2003106438A1
(en)
|
2002-06-18 |
2003-12-24 |
The Scripps Research Institute |
Synthesis of diazonamide "a" core
|
|
US7138412B2
(en)
|
2003-03-11 |
2006-11-21 |
Bristol-Myers Squibb Company |
Tetrahydroquinoline derivatives useful as serine protease inhibitors
|
|
US7129264B2
(en)
|
2003-04-16 |
2006-10-31 |
Bristol-Myers Squibb Company |
Biarylmethyl indolines and indoles as antithromboembolic agents
|
|
JP2007501844A
(ja)
|
2003-08-08 |
2007-02-01 |
トランス テック ファーマ，インコーポレイテッド |
アリール及びヘテロアリール化合物、組成物並びに使用方法
|
|
US7417063B2
(en)
|
2004-04-13 |
2008-08-26 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles useful as serine protease inhibitors
|
|
US7429604B2
(en)
|
2004-06-15 |
2008-09-30 |
Bristol Myers Squibb Company |
Six-membered heterocycles useful as serine protease inhibitors
|
|
US7453002B2
(en)
|
2004-06-15 |
2008-11-18 |
Bristol-Myers Squibb Company |
Five-membered heterocycles useful as serine protease inhibitors
|
|
WO2006017295A2
(en)
|
2004-07-12 |
2006-02-16 |
Idun Pharmaceuticals, Inc. |
Tetrapeptide analogs
|
|
US7459564B2
(en)
|
2005-01-13 |
2008-12-02 |
Bristol-Myers Squibb Company |
Substituted biaryl compounds as factor XIa inhibitors
|
|
US20060183771A1
(en)
|
2005-02-17 |
2006-08-17 |
Seiffert Dietmar A |
Novel combination of selective factor VIIa and/or factor XIa inhibitors and selective plasma kallikrein inhibitors
|
|
WO2007008143A1
(en)
*
|
2005-07-08 |
2007-01-18 |
Astrazeneca Ab |
Heterocyclic sulfonamide derivatives as inhibitors of factor xa
|
|
US20070111947A1
(en)
|
2005-10-14 |
2007-05-17 |
Mcmurry Thomas J |
Fibrin targeted therapeutics
|
|
WO2007054453A2
(en)
|
2005-11-11 |
2007-05-18 |
F. Hoffmann-La Roche Ag |
Carbocyclic fused cyclic amines as inhibitors of the coagulation factor xa
|
|
US8466295B2
(en)
|
2005-12-14 |
2013-06-18 |
Bristol-Myers Squibb Company |
Thiophene derivatives as factor XIa inhibitors
|
|
EA014245B1
(ru)
|
2005-12-14 |
2010-10-29 |
Бристол-Маерс Сквибб Компани |
Аналоги арилпропионамида, арилакриламида, арилпропинамида или арилметилмочевины в качестве ингибиторов фактора xia
|
|
EP1966141A1
(en)
|
2005-12-14 |
2008-09-10 |
Brystol-Myers Squibb Company |
Six-membered heterocycles useful as serine protease inhibitors
|
|
TW200745062A
(en)
|
2005-12-23 |
2007-12-16 |
Bristol Myers Squibb Co |
Macrocyclic factor VIIA inhibitors useful as anticoagulants
|
|
WO2008076805A2
(en)
*
|
2006-12-15 |
2008-06-26 |
Bristol-Myers Squibb Company |
Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor xia inhibitors
|
|
PE20081775A1
(es)
|
2006-12-20 |
2008-12-18 |
Bristol Myers Squibb Co |
Compuestos macrociclicos como inhibidores del factor viia
|
|
CN101784516B
(zh)
|
2007-06-13 |
2014-07-02 |
百时美施贵宝公司 |
作为凝血因子抑制剂的二肽类似物
|
|
JP5537442B2
(ja)
|
2008-03-13 |
2014-07-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
第ｘｉａ因子阻害剤としてのピリダジン誘導体
|
|
US8624040B2
(en)
|
2009-06-22 |
2014-01-07 |
Millennium Pharmaceuticals, Inc. |
Substituted hydroxamic acids and uses thereof
|
|
US8513433B2
(en)
|
2009-07-02 |
2013-08-20 |
Angion Biomedica Corp. |
Small molecule inhibitors of PARP activity
|
|
EP2462123B1
(en)
|
2009-08-04 |
2013-10-02 |
Merck Sharp & Dohme Corp. |
4,5,6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
|
|
US8940720B2
(en)
|
2010-02-11 |
2015-01-27 |
Bristol-Myers Squibb Company |
Macrocycles as factor XIa inhibitors
|
|
US9161924B2
(en)
|
2011-07-08 |
2015-10-20 |
Merck Sharp & Dohme Corp. |
Factor IXa inhibitors
|
|
TW201319068A
(zh)
*
|
2011-08-05 |
2013-05-16 |
必治妥美雅史谷比公司 |
作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
|
|
TW201311689A
(zh)
*
|
2011-08-05 |
2013-03-16 |
必治妥美雅史谷比公司 |
作為因子ｘｉａ抑制劑之新穎巨環化合物
|
|
US9079929B2
(en)
|
2011-10-14 |
2015-07-14 |
Bristol-Myers Squibb Company |
Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
|
|
EP2766345B1
(en)
|
2011-10-14 |
2016-03-16 |
Bristol-Myers Squibb Company |
Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
|
|
LT2766346T
(lt)
|
2011-10-14 |
2017-06-12 |
Bristol-Myers Squibb Company |
Pakeistieji tetrahidroizochinolino junginiai, kaip faktoriaus xia inhibitoriai
|
|
GB2497806A
(en)
|
2011-12-21 |
2013-06-26 |
Ono Pharmaceutical Co |
Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
|
|
CN104136431B
(zh)
|
2011-12-21 |
2017-03-15 |
小野药品工业株式会社 |
作为凝血因子XIa抑制剂的吡啶酮和嘧啶酮衍生物
|
|
WO2013111108A1
(en)
|
2012-01-27 |
2013-08-01 |
Novartis Ag |
5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
|
|
EP2807156A1
(en)
|
2012-01-27 |
2014-12-03 |
Novartis AG |
Aminopyridine derivatives as plasma kallikrein inhibitors
|
|
JP2015083542A
(ja)
|
2012-02-08 |
2015-04-30 |
大日本住友製薬株式会社 |
３位置換プロリン誘導体
|
|
HUE040580T2
(hu)
|
2012-05-10 |
2019-03-28 |
Bayer Pharma AG |
XI. véralvadási faktorhoz és/vagy XIA aktivált alakjához kötõdni képes ellenanyagok és alkalmazásuk
|
|
GB201209138D0
(en)
|
2012-05-24 |
2012-07-04 |
Ono Pharmaceutical Co |
Compounds
|
|
TW201416362A
(zh)
|
2012-07-19 |
2014-05-01 |
Dainippon Sumitomo Pharma Co |
１－（環烷基羰基）脯胺酸衍生物
|
|
CA2880898A1
(en)
*
|
2012-08-03 |
2014-02-06 |
Bristol-Myers Squibb Company |
Dihydropyridone p1 as factor xia inhibitors
|
|
RS55975B1
(sr)
|
2012-08-03 |
2017-09-29 |
Bristol Myers Squibb Co |
Dihidropiridon p1 kao inhibitori xia faktora
|
|
DK2906551T3
(en)
|
2012-10-12 |
2018-05-22 |
Bristol Myers Squibb Co |
CRYSTALLIC FORMS OF A FACTOR XIA INHIBITOR
|
|
EP2906541B1
(en)
|
2012-10-12 |
2017-11-22 |
Bristol-Myers Squibb Company |
Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
|
|
WO2014059202A1
(en)
|
2012-10-12 |
2014-04-17 |
Bristol-Myers Squibb Company |
Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
|
|
EP2934538B1
(en)
|
2012-12-19 |
2021-03-31 |
Merck Sharp & Dohme Corp. |
Factor ixa inhibitors
|
|
GB201300304D0
(en)
|
2013-01-08 |
2013-02-20 |
Kalvista Pharmaceuticals Ltd |
Benzylamine derivatives
|
|
GB2510407A
(en)
|
2013-02-04 |
2014-08-06 |
Kalvista Pharmaceuticals Ltd |
Aqueous suspensions of kallikrein inhibitors for parenteral administration
|
|
JP6479763B2
(ja)
|
2013-03-25 |
2019-03-06 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン
|
|
TWI633089B
(zh)
|
2013-03-28 |
2018-08-21 |
拜耳製藥股份有限公司 |
經取代的酮基吡啶衍生物
|
|
US9475809B2
(en)
|
2013-07-23 |
2016-10-25 |
Bayer Pharma Aktiengesellschaft |
Substituted oxopyridine derivatives and use thereof as factor xia/plasma
|
|
EP3049394A1
(de)
|
2013-09-26 |
2016-08-03 |
Bayer Pharma Aktiengesellschaft |
Substituierte phenylalanin-derivate als faktor xia modulatoren
|
|
AR097755A1
(es)
|
2013-09-26 |
2016-04-13 |
Bayer Pharma AG |
Derivados sustituidos de fenilalanina como moduladores del factor xia
|
|
EP3049403A1
(de)
|
2013-09-26 |
2016-08-03 |
Bayer Pharma Aktiengesellschaft |
Substituierte phenylalanin-derivate
|
|
WO2015044169A1
(de)
|
2013-09-26 |
2015-04-02 |
Bayer Pharma Aktiengesellschaft |
Substituierte phenylalanin-derivate
|
|
TW201605810A
(zh)
|
2013-09-26 |
2016-02-16 |
拜耳製藥股份有限公司 |
經取代苯丙胺酸衍生物（二）
|
|
EP3049410A1
(de)
|
2013-09-26 |
2016-08-03 |
Bayer Pharma Aktiengesellschaft |
Substituierte phenylalanin-derivate als faktor xia modulatoren
|
|
EP3049406A1
(de)
|
2013-09-26 |
2016-08-03 |
Bayer Pharma Aktiengesellschaft |
Substituierte phenylalanin-derivate und ihre verwendung zur behandlung von thrombotischen / thromboembolischen erkrankungen
|
|
US20160222056A1
(en)
|
2013-09-26 |
2016-08-04 |
Bayer Pharma Aktiengesellschaft |
Substituted phenylalanine derivatives
|
|
US20160229839A1
(en)
|
2013-09-27 |
2016-08-11 |
Merck Sharp & Dohme Corp. |
Factor XIa Inhibitors
|
|
EP3054944B1
(en)
|
2013-10-07 |
2019-12-04 |
Merck Sharp & Dohme Corp. |
Factor xia inhibitors
|
|
JP6337750B2
(ja)
|
2013-11-22 |
2018-06-06 |
小野薬品工業株式会社 |
化合物
|
|
KR20160107322A
(ko)
|
2014-01-14 |
2016-09-13 |
다이닛본 스미토모 세이야꾸 가부시끼가이샤 |
축합 ５－옥사졸리디논 유도체
|
|
NO2760821T3
(US07585860-20090908-C00112.png)
|
2014-01-31 |
2018-03-10 |
|
|
|
WO2015116886A1
(en)
|
2014-01-31 |
2015-08-06 |
Bristol-Myers Squibb Company |
Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
|
|
FI3102200T3
(fi)
|
2014-02-07 |
2023-05-31 |
Exithera Pharmaceuticals Inc |
Terapeuttisia yhdisteitä ja koostumuksia
|
|
US9663527B2
(en)
|
2014-02-11 |
2017-05-30 |
Merck Sharp & Dohme Corp. |
Factor XIa inhibitors
|
|
WO2015123093A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Factor xia inhibitors
|
|
WO2015123091A1
(en)
|
2014-02-11 |
2015-08-20 |
Merck Sharp & Dohme Corp. |
Factor xia inhibitors
|
|
CN105829298B
(zh)
|
2014-02-14 |
2019-02-01 |
四川海思科制药有限公司 |
一种吡啶酮或嘧啶酮衍生物、及其制备方法和应用
|
|
LT3828173T
(lt)
|
2014-03-07 |
2022-11-10 |
Biocryst Pharmaceuticals, Inc. |
Pakeistieji pirazolai kaip žmogaus plazmos kalikreino inhibitoriai
|
|
EP3131897B8
(en)
|
2014-04-16 |
2022-08-03 |
Merck Sharp & Dohme LLC |
Factor ixa inhibitors
|
|
WO2015160634A1
(en)
|
2014-04-16 |
2015-10-22 |
Merck Sharp & Dohme Corp. |
Factor ixa inhibitors
|
|
KR20150136294A
(ko)
|
2014-05-27 |
2015-12-07 |
주식회사 레고켐 바이오사이언스 |
인자 ＸＩａ 억제 활성을 가지는 신규한 화합물
|
|
RU2016150410A
(ru)
|
2014-05-28 |
2018-06-28 |
Мерк Шарп И Доум Корп. |
Ингибиторы фактора xia
|
|
US10138236B2
(en)
|
2014-09-24 |
2018-11-27 |
Bayer Pharma Aktiengesellschaft |
Factor xia-inhibiting pyridobenzazepine and pyridobenzazocine derivatives
|
|
NO2721243T3
(US07585860-20090908-C00112.png)
|
2014-10-01 |
2018-10-20 |
|
|
|
WO2016093285A1
(ja)
|
2014-12-10 |
2016-06-16 |
小野薬品工業株式会社 |
ジヒドロインドリジノン誘導体
|
