JP2017525680A5 - - Google Patents

Download PDF

Info

Publication number
JP2017525680A5
JP2017525680A5 JP2017502195A JP2017502195A JP2017525680A5 JP 2017525680 A5 JP2017525680 A5 JP 2017525680A5 JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017525680 A5 JP2017525680 A5 JP 2017525680A5
Authority
JP
Japan
Prior art keywords
seq
sodium
crystals
crystal
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2017502195A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017525680A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/040217 external-priority patent/WO2016010927A1/en
Publication of JP2017525680A publication Critical patent/JP2017525680A/ja
Publication of JP2017525680A5 publication Critical patent/JP2017525680A5/ja
Withdrawn legal-status Critical Current

Links

JP2017502195A 2014-07-14 2015-07-13 結晶性抗体製剤 Withdrawn JP2017525680A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024393P 2014-07-14 2014-07-14
US62/024,393 2014-07-14
PCT/US2015/040217 WO2016010927A1 (en) 2014-07-14 2015-07-13 Crystalline antibody formulations

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2018091269A Division JP2018150337A (ja) 2014-07-14 2018-05-10 結晶性抗体製剤
JP2020115765A Division JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

Publications (2)

Publication Number Publication Date
JP2017525680A JP2017525680A (ja) 2017-09-07
JP2017525680A5 true JP2017525680A5 (enExample) 2018-06-21

Family

ID=53836192

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017502195A Withdrawn JP2017525680A (ja) 2014-07-14 2015-07-13 結晶性抗体製剤
JP2018091269A Pending JP2018150337A (ja) 2014-07-14 2018-05-10 結晶性抗体製剤
JP2020115765A Pending JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2018091269A Pending JP2018150337A (ja) 2014-07-14 2018-05-10 結晶性抗体製剤
JP2020115765A Pending JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

Country Status (7)

Country Link
US (2) US20170198059A1 (enExample)
EP (1) EP3169710A1 (enExample)
JP (3) JP2017525680A (enExample)
AU (2) AU2015289874A1 (enExample)
CA (1) CA2954767A1 (enExample)
MX (1) MX2017000527A (enExample)
WO (1) WO2016010927A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2954773C (en) * 2014-07-14 2023-10-03 Amgen Inc. Crystalline antibody formulations
US20170198059A1 (en) * 2014-07-14 2017-07-13 Amgen Inc. Crystalline antibody formulations
US20170056504A1 (en) * 2015-09-02 2017-03-02 Kenneth I. Kohn Method of extending half-life of crystaline antibodies
EP3596101B1 (en) 2017-03-14 2022-01-05 Amgen Inc. Methods directed to crystalline biomolecules
US12103979B2 (en) 2017-04-28 2024-10-01 Amgen Inc. N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides
MA48461A (fr) * 2017-04-28 2020-03-04 Amgen Inc Excipients pour réduire la viscosité de formulations d'anticorps et compositions de formulation
CN111386281B (zh) * 2017-09-26 2024-03-19 拜康生物制品印度有限公司 用于肽晶体的分离、洗涤和干燥的集成的自动化过滤
GB2584687B (en) * 2019-06-11 2023-08-23 Univ Newcastle Crystallisation of chemical molecules
CN113912622B (zh) 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698393B2 (en) 1994-06-24 1998-10-29 Immunex Corporation Controlled release polypeptide compositions and methods of treating inflammatory bowel disease
IL112834A (en) 1995-03-01 2000-12-06 Yeda Res & Dev Pharmaceutical compositions for controlled release of soluble receptors
US6020004A (en) 1997-04-17 2000-02-01 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US6432449B1 (en) 1998-05-18 2002-08-13 Amgen Inc. Biodegradable sustained-release alginate gels
US6541033B1 (en) 1998-06-30 2003-04-01 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of leptin
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
US6451346B1 (en) 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
EP1345968A2 (en) * 2000-12-28 2003-09-24 Altus Biologics Inc. Crystals of whole antibodies and fragments thereof and methods for making and using them
US8821086B2 (en) * 2006-12-22 2014-09-02 Tennine Corporation Method and apparatus for controlled-fracture machining
WO2008109871A2 (en) * 2007-03-08 2008-09-12 Irm Llc Crystal structure of proprotein convertase 9 (pcsk9) and uses thereof
AR066042A1 (es) * 2007-04-13 2009-07-22 Novartis Ag Moleculas y metodos para modular la proteina convertasa-subtilisina /quexina tipo 9 (pcsk9)
JOP20080381B1 (ar) * 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
US20130072665A1 (en) * 2007-08-23 2013-03-21 Simon Mark Jackson Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
EP2296694B1 (en) * 2008-04-23 2015-08-05 Amgen Inc. Neutralizing proprotein convertase subtilisin kexin type 9 (pcsk9) variants and uses thereof
KR100985090B1 (ko) * 2008-05-23 2010-10-04 한국과학기술연구원 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
WO2011028938A1 (en) * 2009-09-02 2011-03-10 Alnylam Pharmaceuticals, Inc. Methods for lowering serum cholestrol in a subject using inhibition of pcsk9
JO3244B1 (ar) 2009-10-26 2018-03-08 Amgen Inc بروتينات ربط مستضادات il – 23 البشرية
AU2010313324A1 (en) * 2009-10-30 2012-04-12 Merck Sharp & Dohme Corp. AX213 and AX132 PCSK9 antagonists and variants
JO3756B1 (ar) * 2010-11-23 2021-01-31 Regeneron Pharma اجسام مضادة بشرية لمستقبلات الجلوكاجون
CA2825778A1 (en) * 2011-01-28 2012-08-02 Sanofi Pharmaceutical compositions comprising human antibodies to pcsk9
JOP20200043A1 (ar) * 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
US20140004122A1 (en) * 2011-05-10 2014-01-02 Amgen Inc. Methods for treating or preventing cholesterol related disorders
ITPN20110039A1 (it) * 2011-05-24 2012-11-25 Keyline S P A Blocchetto di presa perfezionato per macchina duplicatrice di chiavi
AR087305A1 (es) * 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
EA039663B1 (ru) * 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
US9255154B2 (en) * 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
WO2013170367A1 (en) * 2012-05-17 2013-11-21 The University Of British Columbia Methods and uses for proprotein convert ase subtilisin kexin 9 (pcsk9) inhibitors
AR091462A1 (es) * 2012-06-15 2015-02-04 Genentech Inc Anticuerpos anti-pcsk9, formulaciones, dosificacion y metodos de uso
US20150335615A1 (en) * 2013-01-04 2015-11-26 Toshihisa Kawai Cholesterol-lowering compounds in combination with lipid metabolism-altering compounds of non-absorbable sugars, compounds that convert nh3 to nh4+, or hydrogen-generating compounds for the treatment of high cholesterol and inflammation
WO2014145744A1 (en) * 2013-03-15 2014-09-18 Alder Biopharmaceuticals, Inc. Antibody purification and purity monitoring
AU2014235430A1 (en) * 2013-03-15 2015-09-24 Amgen Inc. Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 (PCSK9)
TW201534324A (zh) * 2013-06-07 2015-09-16 Sanofi Sa 藉由投與pcsk9抑制劑抑制動脈粥狀硬化的方法
JP6267792B2 (ja) * 2013-06-28 2018-01-24 アムジエン・インコーポレーテツド ホモ接合性家族性高コレステロール血症の治療方法
US20150004174A1 (en) * 2013-06-28 2015-01-01 Amgen Inc. Methods for treating homozygous familial hypercholesterolemia
MX373298B (es) * 2013-10-11 2020-05-20 Sanofi Biotechnology Uso de un inhibidor de pcsk9 para tratar la hiperlipidemia.
US10428157B2 (en) * 2013-11-12 2019-10-01 Sanofi Biotechnology Dosing regimens for use with PCSK9 inhibitors
US8883157B1 (en) * 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9023359B1 (en) * 2014-07-15 2015-05-05 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US9034332B1 (en) * 2014-07-15 2015-05-19 Kymab Limited Precision medicine by targeting rare human PCSK9 variants for cholesterol treatment
EA201691320A1 (ru) * 2014-02-14 2016-11-30 Ридженерон Фармасьютикалз, Инк. Способы лечения пациентов с гиперхолестеринемией, которая устойчива к терапии умеренными дозами статинов
BR112016017402A2 (pt) * 2014-02-21 2017-10-17 Medimmune Ltd fusões anti-pcsk9~glp-1 e métodos para uso
CN114558129A (zh) * 2014-03-17 2022-05-31 赛诺菲生物技术公司 用于降低心血管风险的方法
US20150283236A1 (en) * 2014-03-17 2015-10-08 Marie Baccara-Dinet Methods for treating subjects with primary hypercholesterolemia that is not adequately controlled
CA2954773C (en) * 2014-07-14 2023-10-03 Amgen Inc. Crystalline antibody formulations
US20170198059A1 (en) * 2014-07-14 2017-07-13 Amgen Inc. Crystalline antibody formulations
KR20230074283A (ko) * 2014-07-16 2023-05-26 사노피 바이오테크놀로지 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법
EP3197492A1 (en) * 2014-09-23 2017-08-02 Pfizer Inc Treatment with anti-pcsk9 antibodies
EP3439715B1 (en) * 2016-04-08 2021-03-10 Amgen Inc. Drug delivery device
US11596699B2 (en) * 2016-04-29 2023-03-07 CureVac SE RNA encoding an antibody
IL307684B2 (en) * 2016-09-29 2025-04-01 Amgen Inc Low viscosity antigen binding proteins and methods for preparing them
JP7275027B2 (ja) * 2016-10-06 2023-05-17 アムジェン インコーポレイテッド 粘度低下タンパク質医薬製剤
JOP20190112A1 (ar) * 2016-11-14 2019-05-14 Amgen Inc علاجات مدمجة لتصلب الشرايين، شاملة مرض قلبي وعائي تصلبي
US20190031774A1 (en) * 2017-06-09 2019-01-31 Sanofi Biotechnology Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor
KR20200067195A (ko) * 2017-10-18 2020-06-11 리젠엑스바이오 인크. 완전-인간 번역후 변형된 항체 치료제
WO2020014143A1 (en) * 2018-07-08 2020-01-16 Specifica Inc. Antibody libraries with maximized antibody developability characteristics

Similar Documents

Publication Publication Date Title
JP2017525679A5 (enExample)
NZ723369A (en) Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
JP2023515271A5 (enExample)
SI2780368T1 (en) INGREDIENTS AND PROCEDURES FOR INCREASING PURE MASS AND MICROWAVE WITH SPECIFIC ANTAGONISING OF GDF8 AND / OR ACTIVITY A
RU2019138507A (ru) Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1
HRP20240182T1 (hr) Ljudska monoklonska protutijela za teški akutni respiratorni sindrom koronavirusa 2 (sars-cov-2)
JP2023055904A5 (enExample)
JP2020518599A5 (enExample)
JP2015514110A5 (enExample)
JP2016020389A5 (enExample)
IL257281A (en) Anti-pd-1 antibodies and methods of using them
JP2014522236A5 (enExample)
JP2015535828A5 (enExample)
JP2020518598A5 (enExample)
HRP20192288T1 (hr) Postupci liječenja raka primjenom pd-1 antagonista koji vežu os i taksana
PE20142242A1 (es) Anticuerpos humanos anti-cd27, metodos, y usos
IL273841B1 (en) Antibodies targeting cd137 and methods of use thereof
JP2017507657A5 (enExample)
NZ610153A (en) Novel anti-dr5 antibody
AR085575A1 (es) Formulaciones de anticuerpos
JP2024508762A5 (enExample)
JP2020502198A5 (enExample)
NZ741780A (en) Anti-htra1 antibodies and methods of use thereof
JP2012523417A5 (enExample)
EA032189B9 (ru) Изолированные человеческие моноклональные антитела против ингибитора пути тканевого фактора (tfpi) и фармацевтическая композиция, содержащая их