PE20142242A1 - Anticuerpos humanos anti-cd27, metodos, y usos - Google Patents

Anticuerpos humanos anti-cd27, metodos, y usos

Info

Publication number
PE20142242A1
PE20142242A1 PE2014001420A PE2014001420A PE20142242A1 PE 20142242 A1 PE20142242 A1 PE 20142242A1 PE 2014001420 A PE2014001420 A PE 2014001420A PE 2014001420 A PE2014001420 A PE 2014001420A PE 20142242 A1 PE20142242 A1 PE 20142242A1
Authority
PE
Peru
Prior art keywords
seq
group
methods
activity
human antibodies
Prior art date
Application number
PE2014001420A
Other languages
English (en)
Inventor
John Chen
Johan Fransson
Natalie Fursov
Damon Hamel
Thomas Malia
Galina Obmolova
Tatiana Ort
Michael Rycyzyn
Michael Scully
Raymond Sweet
Alexey Teplyakov
John Wheeler
Juan Carlos Almagro
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of PE20142242A1 publication Critical patent/PE20142242A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

SE REFIERE A UN ANTICUERPO HUMANO AISLADO CD27 QUE COMPRENDE UNA REGION VARIABLE DE CADENA LIVIANA; QUE CONTIENE: A) UNA SECUENCIA DE AMINOACIDOS DE LA REGION DETERMINANTE DE COMPLEMENTARIEDAD DE CADENA LIGERA 1 ( CDRL1) SELECCIONADA DEL GRUPO QUE CONSISTE EN SEQ ID N� 59-66 Y 158, CDRL2 SELECCIONADO DEL GRUPO QUE CONSISTE EN SEQ ID N� 67-74, CDRL3 SELECCIONADO DEL GRUPO QUE CONSISTE EN SEQ ID N� 75; Y B) UNA REGION VARIABLE DE CADENA PESADA QUE COMPRENDE: CDRH1 SELECCIONADA DEL GRUPO QUE CONSISTE EN SEQ ID N�42-45 Y 161, CDRH2 SELECCIONADO DEL GRUPO QUE CONSISTE EN 46-57, 156 Y 157, CDRH3 DE SEQ ID N� 58. DICHOS ANTICUERPOS SON UTILES PARA DIAGNOSTICAR O TRATAR LA ACTIVIDAD DE ENFERMEDADES Y ESTADOS ASOCIADOS CON LA ACTIVIDAD DE CD27.
PE2014001420A 2012-03-15 2013-03-14 Anticuerpos humanos anti-cd27, metodos, y usos PE20142242A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261611332P 2012-03-15 2012-03-15

Publications (1)

Publication Number Publication Date
PE20142242A1 true PE20142242A1 (es) 2015-01-08

Family

ID=49157853

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001420A PE20142242A1 (es) 2012-03-15 2013-03-14 Anticuerpos humanos anti-cd27, metodos, y usos

Country Status (28)

Country Link
US (6) US9102737B2 (es)
EP (1) EP2825200A4 (es)
JP (1) JP6487839B2 (es)
KR (1) KR102153374B1 (es)
CN (1) CN104284678B (es)
AR (1) AR090356A1 (es)
AU (1) AU2013232087B2 (es)
BR (2) BR112014022812A2 (es)
CA (1) CA2867299C (es)
CL (1) CL2014002416A1 (es)
CO (1) CO7071095A2 (es)
CR (1) CR20140415A (es)
EA (1) EA030828B1 (es)
EC (1) ECSP14018641A (es)
GT (1) GT201400193A (es)
HK (1) HK1206251A1 (es)
JO (1) JO3787B1 (es)
MX (1) MX363946B (es)
MY (1) MY175224A (es)
NZ (1) NZ629697A (es)
PE (1) PE20142242A1 (es)
PH (2) PH12014502011B1 (es)
SG (2) SG11201405437QA (es)
TW (2) TWI576354B (es)
UA (1) UA121844C2 (es)
UY (1) UY34680A (es)
WO (1) WO2013138586A1 (es)
ZA (2) ZA201407440B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101958753B1 (ko) 2010-04-13 2019-03-15 셀덱스 쎄라퓨틱스, 인크. 인간 ｃｄ27에 결합하는 항체 및 이의 용도
CN103596979B (zh) 2011-03-16 2018-01-26 阿尔金-X有限公司 针对cd70的抗体
WO2014140374A2 (en) * 2013-03-15 2014-09-18 Novo Nordisk A/S Monovalent cd27 antibodies
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
FR3025517B1 (fr) * 2014-09-10 2016-12-23 Repropharm Ligands potentialisants de la bioactivite des gonadotrophines
WO2017044752A1 (en) * 2015-09-10 2017-03-16 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Anti-fibrotic effect of cd70
EA037882B1 (ru) 2015-09-30 2021-05-31 Янссен Байотек, Инк. Агонистические антитела, специфически связывающие человеческий cd40, и способы их применения
MA45488A (fr) 2015-10-22 2018-08-29 Juno Therapeutics Gmbh Procédés, kits et appareil de culture de cellules
CA3002602C (en) * 2015-10-23 2021-11-02 Apogenix Ag Single-chain cd27-receptor agonist proteins
TW201736399A (zh) 2015-12-31 2017-10-16 財團法人生物技術開發中心 抗vegfr抗體及其應用
CN109071665B (zh) 2016-04-18 2022-11-01 塞德斯医疗公司 结合人cd40的激动性抗体及其用途
WO2017220988A1 (en) 2016-06-20 2017-12-28 Kymab Limited Multispecific antibodies for immuno-oncology
JOP20190055A1 (ar) * 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
TW201813979A (zh) * 2016-09-29 2018-04-16 江蘇恆瑞醫藥股份有限公司 抗ｃｄ２７抗體、其抗原結合片段及其醫藥用途
US11242402B2 (en) * 2016-12-23 2022-02-08 Macrogenics, Inc. ADAM9-binding molecules, and methods of use thereof
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
KR20200005596A (ko) 2017-05-12 2020-01-15 크리스퍼 테라퓨틱스 아게 세포를 엔지니어링하기 위한 물질 및 방법, 및 면역-종양학에서의 그의 용도
EP3648757A4 (en) * 2017-07-03 2020-11-25 Development Center for Biotechnology ANTI-VEGFR ANTIBODIES AND USES THEREOF
WO2019037131A1 (zh) * 2017-08-25 2019-02-28 深圳市博奥康生物科技有限公司 一种cd27真核表达载体的构建及其高表达细胞株的制备
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
US11560421B2 (en) * 2018-02-09 2023-01-24 Osaka University Broad-spectrum monoclonal antibodies against chikungunya virus E1 structural protein
US20210009706A1 (en) * 2018-03-28 2021-01-14 Jiangsu Hengrui Medicine Co., Ltd. Anti-CD27 Antibody, Antigen-binding Fragment Thereof, and Medical Use Thereof
US20210155703A1 (en) * 2018-04-04 2021-05-27 Bristol-Myers Squibb Company Anti-cd27 antibodies and uses thereof
US11795230B2 (en) 2018-04-13 2023-10-24 Dingfu Biotarget Co., Ltd. Anti-CD27 antibodies and use thereof
JP7466459B2 (ja) * 2018-04-17 2024-04-12 セルデックス セラピューティクス インコーポレイテッド 抗ｃｄ２７および抗ｐｄ－ｌ１抗体ならびに二重特異性構築物
EP3790629A1 (en) 2018-05-11 2021-03-17 CRISPR Therapeutics AG Methods and compositions for treating cancer
WO2019241730A2 (en) 2018-06-15 2019-12-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
GB201811410D0 (en) 2018-07-12 2018-08-29 F Star Beta Ltd OX40 Binding molecules
WO2020123444A1 (en) 2018-12-11 2020-06-18 Celldex Therapeutics, Inc. Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy
TW202038958A (zh) 2018-12-18 2020-11-01 比利時商阿根思公司 Ｃｄ７０組合治療
US20220144961A1 (en) * 2019-03-11 2022-05-12 Xyence Therapeutics, Inc. Cd27-binding antibodies and uses thereof
MX2021013359A (es) 2019-04-30 2022-01-31 Crispr Therapeutics Ag Terapia de celulas alogénicas de neoplasias malignas de células b usando células t modificadas genéticamente dirigidas a cd19.
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
TW202112812A (zh) * 2019-05-24 2021-04-01 香港商安立璽榮生醫(香港)有限公司 Csf1r抗體、il10融合蛋白及其用途
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
CN116096906A (zh) 2020-06-29 2023-05-09 旗舰创业创新五公司 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
CN112646029B (zh) * 2020-12-30 2022-07-29 深圳清华大学研究院 成熟脑源性神经营养因子的抗体及其应用和诊断试剂盒
US20220325287A1 (en) 2021-03-31 2022-10-13 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
CN113444178B (zh) * 2021-06-17 2022-12-02 南京蓝盾生物科技有限公司 抗cd70内化的抗体、抗体偶联物及其应用
WO2023278641A1 (en) 2021-06-29 2023-01-05 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
WO2024054992A1 (en) 2022-09-09 2024-03-14 Bristol-Myers Squibb Company Methods of separating chelator
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218525B1 (en) 1988-02-25 2001-04-17 The General Hospital Corporation Nucleic acid encoding CD28
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
EP0628639B1 (en) 1991-04-25 1999-06-23 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
WO1993011236A1 (en) 1991-12-02 1993-06-10 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US5573924A (en) 1992-09-08 1996-11-12 Immunex Corporation CD27 ligand
CA2399388A1 (en) 2000-02-11 2001-08-16 Michael J. Lenardo Identification of a domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
US6982361B1 (en) 2000-02-25 2006-01-03 The Regents Of The University Of California Method of screening a compound for anxiolytic activity in an Apolipoprotein e knockout animal
KR100857943B1 (ko) 2000-11-30 2008-09-09 메다렉스, 인코포레이티드 인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
EP1436329A4 (en) 2001-09-20 2005-04-27 Alexion Pharma Inc ANTI-PDGF ANTIBODIES AND METHODS FOR PRODUCING FOCUSED ANTIBODIES
WO2003068268A2 (en) 2002-02-14 2003-08-21 Bioinvent International Ab Treatment, diagnosis and imaging of disease
CA2516128A1 (en) 2003-02-14 2004-09-02 Sagres Discovery, Inc. Therapeutic targets in cancer
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
BRPI0611220A2 (pt) 2005-06-02 2010-08-24 Astrazeneca Ab anticorpos direcionados para cd20 e usos dos mesmos
GB0620894D0 (en) 2006-10-20 2006-11-29 Univ Southampton Human immune therapies using a CD27 agonist alone or in combination with other immune modulators
US8748356B2 (en) 2007-10-19 2014-06-10 Janssen Biotech, Inc. Methods for use in human-adapting monoclonal antibodies
AU2008343589A1 (en) 2007-12-19 2009-07-09 Centocor Ortho Biotech Inc. Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods
EP2090320A1 (en) 2008-02-15 2009-08-19 Helmholtz-Zentrum für Infektionsforschung GmbH Ligands of the Natural Killer (NK) cell surface marker CD27 and therapeutic uses thereof
US9023999B2 (en) * 2008-06-30 2015-05-05 Kyowa Hakko Kirin Co., Ltd Anti-CD27 antibody
KR101773216B1 (ko) * 2009-12-29 2017-08-31 교와 핫꼬 기린 가부시키가이샤 항 ｃｄ27 항체
KR101958753B1 (ko) * 2010-04-13 2019-03-15 셀덱스 쎄라퓨틱스, 인크. 인간 ｃｄ27에 결합하는 항체 및 이의 용도
EP2591001B1 (en) * 2010-07-09 2021-11-17 Aduro Biotech Holdings, Europe B.V. Agonistic antibody to cd27

Also Published As

Publication number Publication date
US10689453B2 (en) 2020-06-23
GT201400193A (es) 2017-06-14
ZA201500887B (en) 2016-01-27
PH12017501908A1 (en) 2018-10-01
US20130243795A1 (en) 2013-09-19
BR112014022812A2 (pt) 2017-07-18
BR122020002414B1 (pt) 2022-03-03
HK1206251A1 (en) 2016-01-08
TW201345922A (zh) 2013-11-16
US20190248910A1 (en) 2019-08-15
PH12014502011A1 (en) 2014-11-24
CN104284678B (zh) 2018-04-24
US20200277393A1 (en) 2020-09-03
PH12017501908B1 (en) 2018-10-01
MX2014011100A (es) 2014-12-05
US20170320957A1 (en) 2017-11-09
TWI576354B (zh) 2017-04-01
CR20140415A (es) 2014-11-18
CL2014002416A1 (es) 2015-01-16
US20240141055A1 (en) 2024-05-02
MX363946B (es) 2019-04-09
KR20140133940A (ko) 2014-11-20
PH12014502011B1 (en) 2014-11-24
US10301392B2 (en) 2019-05-28
ZA201407440B (en) 2016-07-27
EP2825200A1 (en) 2015-01-21
CA2867299A1 (en) 2013-09-19
US20150299330A1 (en) 2015-10-22
US11732050B2 (en) 2023-08-22
SG10201710574UA (en) 2018-02-27
JP2015511965A (ja) 2015-04-23
AR090356A1 (es) 2014-11-05
EA030828B1 (ru) 2018-10-31
CA2867299C (en) 2019-08-27
CO7071095A2 (es) 2014-09-30
UA121844C2 (uk) 2020-08-10
MY175224A (en) 2020-06-16
TW201730214A (zh) 2017-09-01
JP6487839B2 (ja) 2019-03-20
US9102737B2 (en) 2015-08-11
NZ629697A (en) 2017-01-27
EP2825200A4 (en) 2015-08-26
AU2013232087B2 (en) 2018-02-08
AU2013232087A1 (en) 2014-09-25
US9683046B2 (en) 2017-06-20
EA201491700A1 (ru) 2015-02-27
CN104284678A (zh) 2015-01-14
ECSP14018641A (es) 2018-10-31
KR102153374B1 (ko) 2020-09-10
JO3787B1 (ar) 2021-01-31
SG11201405437QA (en) 2014-10-30
UY34680A (es) 2013-09-30
WO2013138586A1 (en) 2013-09-19

Similar Documents

Publication Publication Date Title
PE20142242A1 (es) Anticuerpos humanos anti-cd27, metodos, y usos
IL257281A (en) Anti-pd-1 antibodies and methods of using them
PE20180927A1 (es) Moleculas de union a lag-3 y metodos de uso de las mismas
ES2571129T3 (es) Anticuerpos anti-CTLA4 humanizados
AR081556A1 (es) Proteinas de union al antigeno humanizadas
PE20161033A1 (es) Proteinas de union al antigeno gitr
JP2020500538A5 (es)
AR086044A1 (es) Anticuerpos que se unen especificamente a un dominio extracelular de c-kit y usos de los mismos
PE20170687A1 (es) Proteinas de enlace a cd127
PE20191131A1 (es) Anticuerpos anti antigeno 4 del linfocito t citotoxico (ctla-4) activables y sus usos
AR096687A1 (es) Anticuerpos anti-fcrh5
NZ623347A (en) Novel anti-dr5 antibody
PE20161571A1 (es) Anticuerpos anti-ox40 y metodos de uso
AR066164A1 (es) Proteinas humanas de union a antigenos del factor estimulante de colonias de megacariocitos-macrofagos(gm-csf)
NZ603972A (en) Anti-fgfr2 antibodies
WO2012045481A3 (en) Antibody targeting osteoclast-related protein siglec-15
ES2670621T3 (es) Anticuerpos que se unen a OX40 y sus usos
ES2631135T3 (es) Proteínas de unión a antígeno humanas que se unen a beta-Klotho, receptores de FGF y complejos de los mismos
NZ605980A (en) Anti-fap antibodies and methods of use
CL2013003140A1 (es) Un anticuerpo monoclonal humano aislado o fragmento de union a antigeno del mismo que se une a masp-2 humana; molecula de acido nucleico, casette de expresion, celula que la expresa, metodo de produccion, composicion que la contiene, articulo que lo contiene.
ES2685424T3 (es) Anticuerpos anti-Jagged1 y procedimientos de uso
RS52345B (en) ANTI-IL-23P19 ANTIBODY MANUFACTURED BY GENETIC ENGINEERING
NZ603488A (en) Anti-human respiratory syncytial virus (rsv) antibodies and methods of use
NZ600768A (en) Human antibodies to human angiopoietin-like protein 4
PE20121579A1 (es) Proteinas de enlace al antigeno il-23 humanas

Legal Events

Date Code Title Description
FG Grant, registration