KR100985090B1

KR100985090B1 - 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법

Info

Publication number: KR100985090B1
Application number: KR1020080047946A
Authority: KR
Inventors: 류재천; 김연정; 송미경; 전희경
Original assignee: 한국과학기술연구원
Priority date: 2008-05-23
Filing date: 2008-05-23
Publication date: 2010-10-04
Also published as: KR20090121842A; US8080377B2; US20090291855A1

Abstract

본 발명은 크라이센(chrysene)에 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것으로, 구체적으로 크라이센에 의해 특이적으로 유전자 발현이 증가 또는 감소하는 바이오마커 및 이를 이용한 크라이센에 대한 노출 여부를 확인하는 방법에 관한 것이며, 본 발명의 바이오마커는 DNA 마이크로어레이 칩을 통하여 선별된 반응 유전자들을 바이오마커로 이용하여 환경 시료에서 크라이센의 오염을 모니터링 및 판정하는데 유용하게 사용될 수 있으며, 크라이센에 의해 유발되는 독성 작용 기작을 규명하는 도구로 이용될 수 있다.

크라이센, 다환 방향족 탄화수소, 바이오마커, 마이크로어레이

Description

크라이센 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법{Biomarker for identification of exposure to chrysene and the method of identification using thereof}

본 발명은 크라이센(chrysene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것이다.

다환 방향족 탄화수소류 중의 하나인 크라이센은 불완전 연소로 인해 환경 중으로 배출되며, 주로 유기물 합성이나 화학적 연구목적으로 사용돼서, 상업적으로는 생산하지 않고 있다. 크라이센의 환경 중 동태를 살펴보면, 휘발성이 없어서 토양 중 이동성이 아주 미미하며, 수중에서는 저질과 부유물질에 흡착하여 물표면 중 휘발성도 거의 없다. 토양보다 물에서 미생물의 분해속도가 늦으며, 토양 중 흡착은 미생물의 분해를 저해하는 것으로 알려져 있다. 또한 환경 중에서 가수분해반응은 일어나지 않으며 수생생물 중 생물농축이 아주 낮다. 대기 중에서는 대부분 입자 상태로만 존재하고 있어 주로 물리적인 방법으로 제거될 수 있다.

환경부(1997) 조사에 의하면 국내 대기 및 지하상가에서의 크라이센 농도 조사에서 서울주택가의 경우 1.80 ng/m³, 대전 태평동의 경우 1.2 ng/m³로 검출되었다. 또한 식품 중 다환방향족 탄화수소류의 오염도 조사연구에서 전국 9개 도시에서 유통되는 육류 가공품의 크라이센의 함량을 조사한 결과 훈연제품 0.176 ㎍/㎏, 가금류 식품 0.842 ㎍/㎏, 육류에서 0.143 ㎍/㎏으로 검출되었고(김명철 등, 식품의약품안전청 2001년도 내분비계 장애물질 연구보고서, 2001), 식용유지에서 평균 0.82 ㎍/㎏으로 조사되었다(이종옥 등, 식품의약품안전청 연구보고서 제6권, 790. 2002).

동물실험에서 크라이센은 경구를 통하여 흡수되고, 피부를 통한 흡수는 매우 느리며, 흡수된 대부분은 분변으로 배출되는 것으로 보고되고 있다[ASTDR(Agency for Toxic Substance and Disease Registry), 1990). 또한 크라이센은 효소에 의하여 디하이드로다이올(dihydrodiols)로 변환되며 더 나아가 다이올-에폭사이드(diol-epoxide)로 대사되어 DNA와 결합체를 형성할 수 있고 DNA 부산물을 형성할 수 있다. 크라이센의 다이올-에폭사이드 유도체들이 발암성 및 돌연변이원성을 일으키는 것으로 보고되어지고 있으며, 살모넬라 TA100과 TA 98균주를 이용한 Ames 실험에서 래트(rat) 간의 대사활성 존재 하에서 돌연변이원성을 나타냈다[HSDB(Hazardous Substance Data bank)].

다환방향족 탄화수소류의 발암성 정도와 유전자 발현 변화에 대한 연구는 일 부 보고되고 있지만, 대표적인 다환방향족 탄화수로류로 알려진 벤조에이파이렌(Benzo[a]pyrene)에 대한 연구에 거의 국한되어 있다. 이처럼 크라이센의 인간에 대한 발암 가능성에도 인체에서의 위해도 평가 데이터가 충분하지 않고, 노출에 대한 검색 방법 역시 GC-MS(Gas Chromatography-Mass Spectrometer) 또는 HPLC(High Performance Liquid Chromatography) 등의 고전적인 방법에 국한되어 있다. GC-MS 또는 HPLC 방법 등을 이용하면 정량은 가능하나 분석을 위한 적정 조건을 설정하여야 하며 고가의 장비 등이 필요하다. 그러므로 더욱 빠르고 간편한 스크리닝(screening) 방법, 예를 들면 프라이머(primer)를 이용하는 실시간 PCR(Real-time reverse transcript polymerase chain reaction) 또는 DNA 마이크로어레이 칩 등으로 신속한 위해성 평가를 통해 인체에서의 독성작용을 탐색할 수 있는 분자적 지표를 발굴하고 활용하여 크라이센의 노출에 대한 적절한 대책 및 관리를 수행하는 것이 중요한 과제라 하겠다.

포유류 6종, 미생물 292종 등 여러 종의 게놈(genome) 염기서열 프로젝트가 완성되어 NCBI(National Center for Biotechnology Information)에 보고되었다. 이렇게 얻어진 막대한 양의 데이터를 기본으로 유전자의 기능을 연구하기 위하여 게놈-와이드 익스프레션(genome-wide expression) 연구가 이루어지고 있다. 한 번의 실험으로 수천 개의 유전자의 발현을 분석하기 위하여 DNA 마이크로어레이(microarray) 분석을 수행한다(Schena M et al., Proc . Natl . Acad . Sci . USA 93:10614-10619, 1996).

마이크로어레이는 cDNA(complementary DNA)나 20 - 25 염기쌍(base pair) 길이의 올리고뉴클레오티드(oligonucleotide)들의 세트를 유리에 집적화한 것이다. cDNA 마이크로어레이는 학교 내의 연구실 또는 Agilent, Genomic Solutions 등의 회사에서 칩 위에 cDNA 수집물을 기계적으로 고정화하거나 잉크젯(ink jetting) 방법을 이용하여 생산하고 있다(Sellheyer K et. al., J. Am . Acad . Dermatol. 51:681-692, 2004). 올리고뉴클레오티드 마이크로어레이는 Affymetrix사에서 사진 식각 공정(photolithography)을 이용하여 칩 위에서 직접 합성하는 방법에 의해 만들어지고 있으며, Agillent사 등에는 합성된 올리고뉴클레오티드를 고정화하는 방법으로 생산하고 있다(Sellheyer K et al ., J. Am . Acad . Dermatol. 51:681-692, 2004).

유전자의 발현을 분석을 위해서는 조직 등 시료에서 RNA를 얻어 DNA 마이크로어레이에 있는 올리고뉴클레오티드와 교잡반응을 수행한다. 얻어진 RNA는 형광이나 동위원소로 표지화하며 cDNA로 전환한다. 올리고 마이크로어레이는 주로 두 개의 다른 형광(예: Cye3 및 Cye5)으로 대조군과 실험군을 각각 표지화하여 같은 칩 상에서 동시에 교잡 반응을 수행한 후 광학적으로 이미지를 스캔하여 형광의 세기를 얻고 그 결과를 분석한다. 두 개의 형광 세기의 비율에 따라 유전자의 발현 여부를 결정한다(Somasundaram K et al ., Genomics Proteomics I:1-10, 2002).

최근 DNA 마이크로어레이 기술을 이용한 첨단 기법인 독성 유전체 학(Toxicogenomics) 연구 등과 접목하여 대량(high throughput)으로 의약품 및 신약 후보물질은 물론 대표적인 환경오염물질을 비롯한 모든 화학물질에 의한 특정 조직이나 세포주에서 발현되는 유전자들의 발현 패턴의 분석, 양적 분석이 가능해졌다. 이에 따라 특정 세포 내에서 특정 유전자의 발현 빈도를 분석함으로써 약물의 부작용 및 환경오염물질의 유해작용과 관련된 유전자의 발굴이 가능하며, 이를 통하여 환경오염물질의 유해작용과 약물의 작용 및 부작용에 따른 분자적 메커니즘을 이해하게 될 것이며 나아가 독성 및 부작용을 유발하는 물질의 검색 및 확인할 수 있게 될 것이다.

이에 본 발명자들은 인간 유전자 4만 4천 개가 집적된 올리고마이크로어레이를 이용하여 크라이센의 유전자 발현 프로파일을 인간 간암 세포인 HepG2 세포주에서 관찰 및 분석함으로써 크라이센에 의해 과발현 또는 저발현 되는 유전자를 발굴하고, 실시간(real-time) RT-PCR 방법에 의해 상기 유전자들의 발현 양상을 확인함으로써 크라이센 노출을 검출할 수 있는 바이오마커 및 이를 이용한 노출 여부를 확인하는 방법을 확립하여 본 발명을 완성하였다.

본 발명의 목적은 크라이센(chrysene)의 노출에 의해 과발현 또는 저발현되는 바이오마커를 제공하는 것이다.

본 발명의 다른 목적은 상기 바이오마커를 이용한 크라이센에 대한 노출 여부를 확인하는 방법을 제공하는 것이다.

본 발명의 다른 목적은 상기 바이오마커를 증폭할 수 있는 프라이머를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공하는 것이다.

상기 목적을 달성하기 위하여, 본 발명은 크라이센(chrysene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 바이오마커를 제공한다.

또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 이의 상보가닥 올리고뉴클레오티드가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.

또한, 본 발명은 상기 바이오마커를 이용한 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다.

아울러, 본 발명은 크라이센에 대한 노출 여부 확인용 검색 키트를 제공한다.

이하, 본 발명을 상세히 설명한다.

본 발명은 크라이센(chrysene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 바이오마커를 제공한다.

상기 바이오마커는 2배 이상 발현이 증가 또는 감소한 유전자로써, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자로 구성되어 있다.

본 발명은 하기와 같이 구성된 군에서 선택돼는 것을 특징으로 하는 바이오마커를 제공한다:

유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen- activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번 호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전 자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록 번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번 호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록 번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y- like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번 호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage- gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].

1) 상기 바이오마커 중에서 크라이센의 노출에 의해 발현이 증가하는 바이오마커 유전자는 하기와 같다:

유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha- ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807(APLP1, Amyloid beta(A4) precursor-like protein 1), 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등 록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록 번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen,(lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble(opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번 호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12- hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번 호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번 호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5) 및 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo).

2) 상기 바이오마커 중에서, 크라이센의 노출에 의해 발현이 감소하는 바이오마커 유전자는 하기와 같다:

유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유 전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983(SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번 호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번 호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번 호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번 호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135(DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번 호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유 전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].

본 발명자들은 크라이센에 대한 노출 여부 확인용 바이오마커를 발굴하기 위하여, 크라이센을 인간 간암 세포주(HepG2)에 처리하여 세포 독성을 확인하였다. 그 결과, 상기 크라이센은 인간 간암 세포주에 독성을 가짐이 확인되었고(도 1 참조), 상기 실험을 바탕으로 80%의 세포생존율(IC₂₀)을 보이는 크라이센의 농도를 결정하였다. 이후 상기 결정된 농도로 크라이센을 인간 간암 세포주에 처리하고, 상기 물질을 처리한 세포주에서 mRNA를 분리하여 cDNA를 합성하면서 형광물질(Cy5)로 표지하였으며, 약물을 처리하지 않은 대조군의 경우 Cy3로 표지하였다. 상기 형광표지된 cDNA를 44 k 올리고마이크로어레이 칩 Human whole genome microarray(Agilent, USA)와 혼성화 하였고, 형광 이미지를 스캔하여 유전자 발현 양상의 차이를 분석하였다(도 2 참조). 분석시 Cy5/Cy3 비율이 2.0배 이상인 경우 발현 증가된 유전자로 분류하였고, 0.5배 이하인 경우 발현 감소된 유전자로 분류하였다. 분석 결과, 발현 증가된 유전자는 0.73%(44,000개의 유전자 중 323개), 발현이 감소된 유전자는 0.82%(44,000개의 유전자 중 361개)임을 확인하였다. 이때, 크라이센에 의해 2배 이상 과발현 또는 저발현 되는 유전자들을 분류한 기능별로 분류하면, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자들이었다(표 2 및 표 3참조). 상기 유전자들은 본 발명에서 사용한 크라이센을 처리했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.

본 발명자들은 상기 유전자 중 과발현된 유전자 25종과 저발현된 유전자 10종을 분리하여 상기 유전자들을 증폭할 있는 프라이머(표 4 참조)를 설계하여, 실시간 RT-PCR(real-time reverse transcript polymerase chain reaction) 방법으로 발현 양상을 조사하였다. 그 결과, 25종의 과발현 유전자들과 10종의 저발현 유전자의 발현 양상이 올리고마이크로어레이 칩 결과와 유사하게 나타남을 확인하였다(표 5 참조). 이들 유전자들은 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_004881(Tumor protein p53 inducible protein 3), 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_006426(Dihydropyrimidinase-like 4), 유전자 등록번호(Genebank) NM_133493[CD109 antigen(Gov platelet alloantigens)], 유전자 등록번호(Genebank) AB033073(Sulfatase 2), 유전자 등록번호(Genebank) NM_021603(FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AK097009(phospholipid transfer protein), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) BU587578(Regulator of G-protein signalling 10), 유전자 등록번호(Genebank) BQ683841[S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) NM_001013632[polo-like kinase 3(Drosophila)], 유전자 등록번호(Genebank) NM_032872(Synaptotagmin-like 1), 유전자 등록번호(Genebank) BC042390[Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000596(Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_005319(Histone 1, H1c), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769[CD9 antigen(p24)], 유전자 등록번호(Genebank) NM_001553(Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410[MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa) 및 유전자 등록번호(Genebank) BC022255[Spindle pole body component 25 homolog(S. cerevisiae)] 등이다.

또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 그의 상보 가닥 분자가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.

상기 올리고 뉴클레오티드 또는 이의 상보가닥 올리고뉴클레오티드는 상기 바이오마커 유전자의 18 내지 30개의 핵산을 포함하고, 바람직하게는 20 내지 25개의 핵산을 포함한다.

본 발명의 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩은 당업자에게 알려진 방법으로 제작할 수 있다. 상기 마이크로어레이 칩을 제작하는 방법은 하기와 같다. 상기 탐색된 바이오마커를 탐침 DNA 분자로 이용하여 DNA 칩의 기판상에 고정화시키기 위해 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로파이펫팅(micropipetting)법 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니다. 상기 DNA 마이크로어레이 칩의 기판은 아미노-실란(amino-silane), 폴리-L-라이신(poly-L-lysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 하나의 활성기가 코팅된 것이 바람직하나 이에 한정되는 것은 아니다. 또한, 상기 기판은 슬라이드 글래스, 플라스틱, 금속, 실리콘, 나일론 막, 및 니트로셀룰로스 막(nitrocellulose membrane)으로 이루어진 군에서 선택될 수 있으나 이에 제한되는 것은 아니다.

본 발명은 하기와 같은 과정을 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다:

1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;

2) 단계 1)의 실험군과 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질을 표지하는 단계;

3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 본 발명의 DNA 마이크로어레이칩과 혼성화 시키는 단계;

4) 단계 3)의 반응한 DNA 마이크로어레이 칩을 분석하는 단계; 및

5) 단계 4)의 분석한 데이터에서 본 발명의 바이오마커의 발현 정도를 대조군과 비교하여 확인하는 단계.

상기 바이오마커를 검출하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다. 이때, 상기 피검체는 크라이센에 노출된 것이 의심되는 개체이고, 대조군은 건강한 인간 개체일 것이다.

상기 바이오마커를 검출하는 방법에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 형광물질은 모두 사용 가능하다.

상기 바이오마커를 검출하는 방법에 있어서, 단계 4)의 DNA 마이크로어레이 칩은 Whole Human Genome Oligo Microarray(Agilent, USA) 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간 게놈 중 본 발명에서 상기 과발현 또는 저발현 유전자(표 2 및 표 3 참조)가 탑재된 마이크로어레이 칩이라면 사용 가능하고, 상기 본 발명자가 제작한 DNA 마이크로어레이 칩을 사용하는 것이 가장 바람직하다. 또한, 단계 4)의 분석 방법은 GenePix 4.1 소프트웨어(Axon Instruments, USA)를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 분석 소프트웨어를 사용하여도 무방하다.

또한, 본 발명은 하기와 같은 과정을 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다:

2) 단계 1)의 RNA를 대상으로, 본 발명의 바이오마커 유전자에 상보적이고 바이오마커 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및

3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계.

상기 바이오마커를 검출하는 방법에 있어서, 단계 2)의 프라이머는 본 발명에서 탐색된 바이오마커 유전자와 상보적이고, 바이오마커를 증폭할 수 있는 프라이머라면 모두 사용가능하다. 본 발명에서는 서열번호 1 내지 70으로 기재되는 정방향 및 역방향의 프라이머 35쌍을 제시하였으나 이에 한정되는 것은 아니다.

또한, 본 발명은 크라이센에 대한 노출 여부 확인용 키트를 제공한다.

본 발명은 상기 본 발명에서 제작한 DNA 마이크로어레이 칩을 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다.

상기 확인용 키트에 추가적으로 인간 간세포를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다. 상기 인간 간세포는 HepG2를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간의 간 또는 간암의 세포 및 조직에서 유 래한 세포라면 모두 사용 가능하다.

상기 키트에 추가적으로 형광물질을 포함할 수 있으며, 상기 형광물질은 스트렙아비딘-알칼리 탈인화효소 접합물질(strepavidin-like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 Cy3와 Cy5를 사용하였다.

상기 키트에 추가적으로 반응 시약을 포함시킬 수 있으며, 상기 반응 시약은 혼성화에 사용되는 완충용액, RNA로부터 cDNA를 합성하기 위한 역전사효소, cNTPs 및 rNTP(사전 혼합형 또는 분리 공급형), 형광 염색제의 화학적 유도제와 같은 표식시약, 세척 완충용액 등으로 구성될 수 있으나 이에 한정된 것은 아니며, 당업자에게 알려진 DNA 마이크로어레이 칩의 혼성화 반응에 필요한 반응 시약은 모두 포함시킬 수 있다.

아울러, 본 발명은 상기 바이오마커 유전자에 상보적이고, 바이오마커 유전자를 증폭할 수 있는 프라이머를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다.

상기 확인용 키트의 프라이머는 서열번호 1 내지 70으로 기재되는 서열로 구성된 군으로부터 선택되는 2개 이상의 정방향 및 역방향의 프라이머를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 상기 바이오마커 유전자에 상보적이며, 바이오마커 유전자를 증폭할 수 있으며 증폭 산물이 100 내지 300 bp가 되도록 설 계된 정방향 및 역방향 프라이머쌍은 모두 사용 가능하다.

본 발명은 크라이센에 노출되었을 때에 특이적으로 발현이 증가 또는 감소되는 DNA 단편을 크라이센에 노출 여부 확인용 바이오마커로 이용하여 크라이센의 모니터링 및 위해성을 판정하는데 유용하며, 크라이센에 의해 야기되는 독성 작용 기작을 규명하는 도구로 이용할 수 있다.

이하, 본 발명을 실시예에 의해 상세히 설명한다.

단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.

<실시예 1> 세포 배양 및 화학물질 처리

<1-1> 세포배양

인간 간암 세포주인 HepG2 세포(한국 세포주 은행)를 10% FBS가 첨가된 DMEM 배지(Gibro-BRL, USA)를 이용하여 100 ㎜ 디쉬(dish)에서 80% 정도 자랄 때까지 배양하였다. 본 발명자들은 기존의 연구와 보고를 통해 다환방향족 탄화수소류의 하나로서 발암성이 있는 물질인 크라이센(Sigma-Aldrich, USA)을 선정하였으며, DMSO에 용해시켰다. 매질(vehicle) 농도는 모든 실험에서 0.1% 이하였다.

<1-2> 세포 독성 실험(MTT assay) 및 화학 물질 처리

Mossman 등(J. Immunol. Methods, 65, 55-63, 1983)의 방법으로 HepG2 세포주를 이용한 MTT 실험을 수행하였다. 세포는 24-웰 플레이트에 4× 10⁵/웰 세포수로 DMEM 배지(Gibro-BRL, USA)에서 DMSO에 용해된 크라이센을 처리하고 48시간 후에 MTT(3-4,5-dimethylthiazol-2,5-diphenyltetra zolium bromide) 5 ㎎/㎖을 혼합하여 튜브에 가하여 37℃에서 3 시간 동안 배양하였다. 이 후 배지를 제거하고 형성된 포르마잔 크리스탈(formazan crystal)을 DMSO 500 ㎕에 용해하였다. 96-웰 플레이트로 옮겨 분주(aliquot)하고 흡광도 540 ㎚에서 O.D.값을 측정하였다.

HepG2 세포주에서 크라이센의 세포독성을 살펴본 결과, 80% 세포생존율을 보이는 농도(IC₂₀)는 34.97 μM 이었으며(도 1), 상기 농도들로 결정하여 마이크로어레이 실험을 수행하였다.

<실시예 2> 마이크로어레이 실험

<2-1> 표적 RNA의 분리 및 형광 물질 표지

6 × 10⁶ cell/㎖ 농도로 100 ㎜ 디쉬에 HepG2 세포를 분주한 후, 실시예 1-2에서 결정된 크라이센의 농도를 48 시간 동안 처리하였다. 이후, 상기 처리한 세포에서 트리졸(trizol) 시약(Invitrogen life technologies, USA)을 사용하여 제조사의 방법대로 전체 RNA를 분리하고, RNeasy mini kit(Qiagen, USA)를 사용하여 정 제하였다. 게놈 DNA는 RNA 정제 동안 RNase-free DNase set(Qiagen, USA)를 사용하여 제거하였다. 각 전체 RNA 시료의 양은 분광광도계로 측정하였고, 농도는 Agilent 2100 Bioanalyzer(Agilent Technologies, USA)와 아가로스 젤 전기영동으로 확인하였다.

<2-2> 표지된 cDNA 제조

올리고 마이크로어레이 분석을 위하여 실시예 2-1에서 수득한 크라이센 처리군의 전체 RNA를 사용하여 cDNA를 제조하였다. 상기 수득한 전체 RNA 30 ㎍과 올리고(dT) 프라이머 2 ㎍(1 ㎍/㎕)과 혼합하고 65℃에서 10분간 반응시킨 후 바로 얼음에 넣어 어닐링(annealing)시켰다. 상기 어닐링된 RNA의 역전사(Reverse Transcript) 반응을 위해 표 1과 같이 시약을 혼합하였다.

구성	부피(㎕)
5X first strand buffer	6
dNTPs	0.6
0.1 M DDT	3
SuperScript II enzyme	3
Cy-3 or Cy-5 dUTP	2

대조군인 HepG2 세포주에서 분리한 전체 RNA는 Cy3-dUTP(녹색)로 표지화 하였고, 크라이센을 처리한 HepG2 세포주로부터 분리한 RNA는 Cy5-dUTP(적색)로 표지화 하였다. 이때 두 시료는 Microcon YM-30 컬럼(Millipore, USA)을 사용하여 혼합, 정제되었다.

<2-3> 혼성화 반응

혼성화 및 세척 과정은 지노첵(주)의 지시방법에 따라 수행되었다. 혼성화는 12시간 동안 62℃ 오븐에서 수행되었다. DNA 마이크로어레이 칩으로는 44 k Whole Human Genome Oligo Microarray(Agilent, USA)를 이용하였다. 세척(2분간 2× SSC/0.1% SDS에 세척, 3분간 1× SSC, 2분간 0.2× SSC에 세척) 후 슬라이드는 3분간 800 rpm으로 원심분리 하여 건조하였다.

<2-4> 형광 이미지 획득

슬라이드 상의 혼성화 이미지는 Genepix 4000B(Axon Instruments, USA)로 스캔하였다. 결합하지 않은 유전자를 세척한 칩은 레이저 광 스캐너(laser fluorescence scanner)를 사용하여 형광 이미지를 획득하였다. 이때 녹색 형광 이미지는 대조군에서, 적색 형광 이미지는 실험군에서만 특이하게 발현되는 유전자의 활성정도를 나타내게 되며, 노란색 형광 이미지는 녹색과 적색의 보색으로 두 군의 발현이 큰 차이가 없음을 의미한다. 스캔한 이미지들은 유전자 발현 비율을 얻기 위하여 GenePix 4.1 소프트웨어(Axon Instruments, USA)로 분석하였다(도 2). 이렇게 하여 얻어진 데이터로부터 크라이센에 대한 마커 유전자를 선별하였다.

그 결과, 올리고 칩 상에 존재하는 대략 4만 4천 개의 유전자 중에서 크라이센에 의해 Cy5/Cy3의 비율이 2.0배 이상으로 유전자 발현 증가를 보이는 유전자는 0.73%(44,000개의 유전자 중 323개) 발현이 감소된 유전자는 0.82%(44,000개의 유전자 중 361개)임을 확인하였다.

이때, 크라이센에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 기능별로 분류한 결과, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자로 분류되었다(표 2 및 3). 상기 유전자들은 본 발명에서 사용한 크라이센을 처리 했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.

크라이센에 의해 발현이 증가하는 유전자

등록번호	유전자약어	유전자명	중간값의비
(a) MAPKinase 신호 경로(MAPKinase Signaling Pathway)
NM_003954	MAP3K14	Mitogen-activated protein kinase kinase kinase 14	2.642090915
AB209586	MAPK13	Mitogen-activated protein kinase 13	2.32604791
NM_005343	HRAS	V-Ha-ras Harvey rat sarcoma viral oncogene homolog	2.300183763
BX647104	FOS	V-fos FBJ murine osteosarcoma viral oncogene homolog	2.286644731
NM_007315	STAT1	Signal transducer and activator of transcription 1, 91kDa	2.268249473
BC027933	MAPK11	Mitogen-activated protein kinase 11	2.256117014
NM_020529	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	2.242341043
BC014966	RPS6KA1	Ribosomal protein S6 kinase, 90kDa, polypeptide 1	2.109933874
(b) p53 신호 경로(p53 Signaling Pathway)
NM_181861	APAF1	Apoptotic peptidase activating factor	2.323610287
L41870	RB1	Retinoblastoma 1 (including osteosarcoma)	2.431277919
CR612719	GADD45A	Growth arrest and DNA-damage-inducible, alpha	2.785095956
BM462208	PCNA	Proliferating cell nuclear antigen	5.94704061
M92424	MDM2	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)	4.056640879
NM_078467	CDKN1A	Cyclin-dependent kinase inhibitor 1A(p21, Cip1)	21.05152341
(c) 아팝토시스(Apoptosis)
BC089389	IHPK3	Inositol hexaphosphate kinase 3	17.86623375
NM_001024807	APLP1	Amyloid beta(A4) precursor-like protein 1	14.60038469
NM_001013398	IGFBP3	Insulin-like growth factor binding protein 3	11.51469533
AB209361	FAS	Fas(TNF receptor superfamily, member 6)	9.282797498
NM_147780	CTSB	Cathepsin B	6.625352723
NM_001165	BIRC3	Baculoviral IAP repeat-containing 3	6.105445052
BM557864	HSPB1	Heat shock 27kDa protein 1	5.988972006
AB033060	PDCD6	Aryl-hydrocarbon receptor repressor	5.709323333
AK125880	TP53INP1	Tumor protein p53 inducible nuclear protein 1	4.730741529
NM_004574	04-Sep	Septin 4	4.420718644
NM_003820	TNFRSF14	Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)	4.241834154
CN478604	LGALS7	Lectin, galactoside-binding, soluble, 7(galectin 7)	4.215529017
NM_004879	EI24	Etoposide induced 2.4 mRNA	3.840012717
NM_003311	PHLDA2	Pleckstrin homology-like domain, family A, member 2	3.66045378
NM_003897	IER3	Immediate early response 3	3.323689948
AK097284	TNFAIP8	Tumor necrosis factor, alpha-induced protein 8	3.301416171
NM_000582	SPP1	Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	3.007301243
NM_013258	PYCARD	PYD and CARD domain containing	2.704730239
NM_002305	LGALS1	Lectin, galactoside-binding, soluble, 1(galectin 1)	2.685571797
AF055634	UNC5C	Unc-5 homolog C(C. elegans)	2.64453651
CR614015	CD14	CD14 antigen	2.620138457
AK129595	GADD45B	Growth arrest and DNA-damage-inducible, beta	2.431892144
AF356193	CARD6	Caspase recruitment domain family, member 6	2.315498432
BC063043	PRF1	Perforin 1(pore forming protein)	2.300936607
BX537586	STK17A	Serine/threonine kinase 17a(apoptosis-inducing)	2.173582084
NM_003842	TNFRSF10B	Tumor necrosis factor receptor superfamily, member 10b	2.164540104
AF208043	IFI16	Interferon, gamma-inducible protein 16	2.147368247
BX641114	ANXA4	Annexin A4	2.143018533
NM_001009552	PPP2CB	Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	2.132316431
BX386171	CGB5	Chorionic gonadotropin, beta polypeptide 8	2.11678504
AY358103	HIP1	Huntingtin interacting protein 1	2.101135287
BC027949	P2RX1	Purinergic receptor P2X, ligand-gated ion channel, 1	2.093924251
BC042844	CASP10	Caspase 10, apoptosis-related cysteine peptidase	2.071460864
NM_000733	CD3E	CD3E antigen, epsilon polypeptide(TiT3 complex)	2.069295152
NM_033245	PML	Promyelocytic leukemia	2.031289487
BC047362	PHLDA1	Pleckstrin homology-like domain, family A, member 1	2.030766246
(d) DNA 손상에 대한 반응(Response to DNA damage stimulus)
NM_006763	BTG2	BTG family, member 2	8.033431013
BC050455	DDB2	LIM homeobox 3	5.130890941
BC068535	TP53AP1	TP53 activated protein 1	3.847202974
AF033122	SESN1	Sestrin 1	3.728462177
AB024313	POLH	Polymerase(DNA directed), eta	3.515123881
NM_001012716	TYMS	Thymidylate synthetase	3.123891212
BC095402	ATXN3	Ataxin 3	2.201860506
BU675073	PTTG1	Pituitary tumor-transforming 1	2.178628404
BC073161	RAD51C	RAD51 homolog C(S. cerevisiae)	2.092699518
NM_001983	ERCC1	Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	1.811298942
(e) 스트레스에 대한 반응(Response to stress)
NM_018965	TREM2	Triggering receptor expressed on myeloid cells 2	43.66510076
BX649164	PAI; PAI1; PAI-1; PLANH1	serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1	29.04597327
NM_006404	PROCR	Protein C receptor, endothelial(EPCR)	24.52788989
BC035582	TRIM22	Tripartite motif-containing 22	13.78919459
NM_006691	XLKD1	Extracellular link domain containing 1	10.05591814
NM_015831	ACHE	Acetylcholinesterase (YT blood group)	6.223349052
BC045666	TP53I11	Tumor protein p53 inducible protein 11	6.007745545
NM_005438	FOSL1	FOS-like antigen 1	5.642502876
NM_005755	EBI3	Epstein-Barr virus induced gene 3	5.606891978
BM918324	LY96	Lymphocyte antigen 96	5.438550593
NM_000022	ADA	Adenosine deaminase	5.212717207
NM_004167	CCL14	Chemokine(C-C motif) ligand 15	5.102559642
NM_014278	HSPA4L	Heat shock 70kDa protein 4-like	4.710398517
BC006523	SGK2	Serum/glucocorticoid regulated kinase 2	4.64953324
NM_000641	IL11	Interleukin 11	4.520629217
H18681	C20orf139	Sulfiredoxin 1 homolog(S. cerevisiae)	4.383369833
NM_001769	CD9	CD9 antigen(p24)	4.153073307
BG564326	SAA4	Serum amyloid A4, constitutive	4.075835655
NM_016816	OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	3.710610826
CB055213	ICOSLG	Inducible T-cell co-stimulator ligand	3.643779829
CR591007	CCL3	Chemokine(C-C motif) ligand 3	3.346884519
NM_145641	APOL3	Apolipoprotein L, 3	3.195513004
AK127663	PTGES	Prostaglandin E synthase	3.183821649
NM_001734	C1S	Complement component 1, s subcomponent	3.018342133
NM_002260	KLRC3	Killer cell lectin-like receptor subfamily C, member 2	2.941895363
NM_001733	C1R	Complement component 1, r subcomponent	2.893399755
AB209922	DNAJB4	DnaJ(Hsp40) homolog, subfamily B, member 4	2.872000914
NM_201397	GPX1	Glutathione peroxidase 1	2.850015447
AK090482	CXCL12	Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)	2.842225911
BF662985	CCL3L1	Chemokine(C-C motif) ligand 3-like 1	2.838582233
NM_001779	CD58	CD58 antigen, (lymphocyte function-associated antigen 3)	2.794341637
NM_005064	CCL23	Chemokine(C-C motif) ligand 23	2.761400386
NM_000242	MBL2	Mannose-binding lectin(protein C) 2, soluble(opsonic defect)	2.755428358
NM_032036	FAM14A	Family with sequence similarity 14, member A	2.706203775
AJ890082	HSPCA	Heat shock 90kDa protein 1, alpha	2.54395008
BC068487	TLR3	Toll-like receptor 3	2.540522037
NM_000552	VWF	Von Willebrand factor	2.476094941
NM_000132	F8	Coagulation factor VIII, procoagulant component(hemophilia A)	2.414521007
AY154461	NALP6	NACHT, leucine rich repeat and PYD containing 6	2.392028958
AK127679	DUSP1	Dual specificity phosphatase 1	2.382519952
NM_014314	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	2.333495418
NM_000311	PRNP	Prion protein (p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)	2.313144503
NM_006597	HSPA8	Heat shock 70kDa protein 8	2.313144445
AK092040	ZCSL2	Zinc finger, CSL-type containing 2	2.303019345
NM_031483	ITCH	Itchy homolog E3 ubiquitin protein ligase(mouse)	2.300924118
U25029	NR3C1	Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)	2.273770608
NM_005242	F2RL1	Coagulation factor II (thrombin) receptor-like 1	2.25765938
AK172851	ADORA2B	Adenosine A2b receptor	2.248876245
BQ053419	BATF	Basic leucine zipper transcription factor, ATF-like	2.220924757
BC020698	CCL20	Chemokine(C-C motif) ligand 20	2.199037915
NM_001124	ADM	Adrenomedullin	2.186497254
NM_153609	TMPRSS6	Transmembrane protease, serine 6	2.118468174
NM_004148	NINJ1	Ninjurin 1	2.106988819
AF324224	APOL2	Apolipoprotein L, 2	2.105247356
BC040494	DNAJB2	DnaJ(Hsp40) homolog, subfamily B, member 2	2.053186934
BE512691	GPX2	Glutathione peroxidase 2(gastrointestinal)	2.014366573
NM_001002029	C4A	Complement component 4B, telomeric	2.002292152
(f) 면역 반응(Immune response)
NM_000732	CD3D	CD3D antigen, delta polypeptide(TiT3 complex)	54.93792815
AK223210	CD79B	CD79B antigen (immunoglobulin-associated beta)	15.33023863
NM_002309	LIF	Hypothetical protein MGC20647	8.088491848
AF031469	MR1	Major histocompatibility complex, class I-related	7.058743082
NM_172208	TAPBP	TAP binding protein (tapasin)	7.020261414
BC021117	CSF1	Colony stimulating factor 1(macrophage)	4.788017417
NM_001421	ELF4	E74-like factor 4 (ets domain transcription factor)	4.315617246
NM_002119	HLA-DOA	Major histocompatibility complex, class II, DO alpha	4.208814419
BX648013	TAP1	Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)	4.079915559
AL832287	ZAP70	Zeta-chain(TCR) associated protein kinase 70kDa	3.830282261
BF569086	NK4	Interleukin 32	3.137700229
AL832451	DKFZp451C2311	guanylate binding protein 2, interferon-inducible	2.638811674
AF069493	SEMA7A	Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A	2.530855422
NM_001008490	KLF6	Kruppel-like factor 6	2.300245668
NM_000418	IL4R	Interleukin 4 receptor	2.254471504
NM_004048	B2M	Beta-2-microglobulin	2.006239064
(g) 세포 주기(Cell cycle)
AF116720	DNAJA2	DnaJ(Hsp40) homolog, subfamily A, member 2	10.94418029
NM_001007271	DUSP13	Dual specificity phosphatase 13	7.030871577
BM904612	S100A6	S100 calcium binding protein A6(calcyclin)	5.937525522
AK074652	SERTAD1	SERTA domain containing 1	4.83549333
NM_203394	E2F7	E2F transcription factor 7	3.647469222
NM_003620	PPM1D	Protein phosphatase 1D magnesium-dependent, delta isoform	3.646783838
BC060797	PARD6G	Par-6 partitioning defective 6 homolog gamma(C. elegans)	3.501662527
NM_021913	AXL	AXL receptor tyrosine kinase	3.268484061
BC040303	PTP4A1	Protein tyrosine phosphatase type IVA, member 1	3.182840665
BC008564	PPP1R9B	Protein phosphatase 1, regulatory subunit 9B, spinophilin	3.169099614
AK097024	RAE1	RAE1 RNA export 1 homolog(S. pombe)	2.920923726
BC011957	BTG3	BTG family, member 3	2.73961999
NM_078487	CDKN2B	Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)	2.55897751
BC023552	SFN	Stratifin	2.524571283
BC060847	PARD6B	Par-6 partitioning defective 6 homolog beta(C. elegans)	2.507221799
NM_003236	TGFA	Transforming growth factor, alpha	2.487048846
NM_002632	PGF	Placental growth factor, vascular endothelial growth factor-related protein	2.435909331
NM_015278	SASH1	SAM and SH3 domain containing 1	2.368157793
AL834276	MGC3207	Hypothetical protein MGC3207	2.364392455
AK096276	CCND3	Cyclin D3	2.291774022
AB209373	CCNK	Chromosome 14 open reading frame 65	2.27376643
NM_021132	PPP3CB	Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)	2.19575961
NM_005072	SLC12A4	Solute carrier family 12(potassium/chloride transporters), member 4	2.184117922
BX647886	PCNP	SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)	2.132837165
NM_044472	CDC42	Cell division cycle 42(GTP binding protein, 25kDa)	2.08723035
AL832973	REC8L1	REC8-like 1(yeast)	2.050105112
NM_002031	FRK	Fyn-related kinase	2.008244265
(h) 세포 분화(Cell differentiation)
BM913048	TIMP1	TIMP metallopeptidase inhibitor 1	14.51811118
NM_003975	SH2D2A	SH2 domain protein 2A	6.609387012
NM_198129	LAMA3	Laminin, alpha 3	6.313840426
NM_006152	LRMP	Lymphoid-restricted membrane protein	3.452878243
X96753	CSPG4	Chondroitin sulfate proteoglycan 4(melanoma-associated)	3.342871665
NM_000474	TWIST1	Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)	2.962045566
AF052152	DCAMKL1	Doublecortin and CaM kinase-like 1	2.946594775
AF333334	CCIN	Calicin	2.907611782
NM_005979	S100A13	S100 calcium binding protein A13	2.38786608
NM_004429	EFNB1	Ephrin-B1	2.290394007
NM_003873	NRP1	Neuropilin 1	2.102000337
AF026692	SFRP4	Secreted frizzled-related protein 4	2.097767188
AK124583	DAZAP1	DAZ associated protein 1	2.09304534
AF003837	JAG1	Jagged 1(Alagille syndrome)	2.052565745
AB209590	BMP1	Bone morphogenetic protein 1	2.018231591
(i) 세포 성장(Cell growth)
X54457	CEL	Carboxyl ester lipase (bile salt-stimulated lipase)	11.0110822
Y11307	CYR61	Cysteine-rich, angiogenic inducer, 61	8.870510533
NM_000596	IGFBP1	Insulin-like growth factor binding protein 1	4.426373693
NM_020997	LEFTY1	Left-right determination factor 1	4.011782013
NM_001553	IGFBP7	Insulin-like growth factor binding protein 7	3.467233091
AB209509	IGFBP2	Insulin-like growth factor binding protein 2, 36kDa	2.280688594
NM_001552	IGFBP4	Insulin-like growth factor binding protein 4	2.170002081
AB209321	CSRP2	Cysteine and glycine-rich protein 2	2.079139635
BM556279	EMP3	Epithelial membrane protein 3	2.029076597
(j) 세포 증식(Cell proliferation)
NM_005727	TSPAN1	Tetraspanin 1	8.454659213
BQ683841	S100A11	S100 calcium binding protein A11(calgizzarin)	6.064178076
BC042390	VTI1B	Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)	4.485613104
NM_000899	KITLG	KIT ligand	3.751569954
BC032940	LAMP3	Lysosomal-associated membrane protein 3	2.728811271
BQ939577	AKR1C3	Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)	2.683290824
BC063468	OSMR	Oncostatin M receptor	2.652841837
CR936719	SSR1	Signal sequence receptor, alpha(translocon-associated protein alpha)	2.559482267
AB024057	TBC1D8	TBC1 domain family, member 8(with GRAM domain)	2.53463919
NM_003329	TXN	Thioredoxin	2.324939817
NM_012125	CHRM5	Cholinergic receptor, muscarinic 5	2.112618735
NM_007045	FGFR1OP	FGFR1 oncogene partner	2.09430482
(k) 알코올 대사(Alcohol metabolism)
AK094474	RHOC	Ras homolog gene family, member C	4.227972245
BC017706	6PGL	6-phosphogluconolactonase	2.621428387
AF153821	ADH1B	Alcohol dehydrogenase IB(class I), beta polypeptide	2.420867965
AK124656	ENO2	Enolase 2(gamma, neuronal)	2.273190922
D42047	GPD1L	Glycerol-3-phosphate dehydrogenase 1-like	2.170305169
AK130060	TALDO1	Transaldolase 1	2.107113338
AL833069	KIAA1434	Hypothetical protein KIAA1434	2.042123428
XM_496436	UNQ6077	C219-reactive peptide	2.011483091
NM_199186	BPGM	2,3-bisphosphoglycerate mutase	2.001621684
(l) DNA 대사(DNA metabolism)
U86136	TEP1	Telomerase-associated protein 1	5.354849784
BU603483	HIST1H1E	Histone 1, H1e	4.639090453
NM_005319	HIST1H1C	Histone 1, H1c	4.25715277
NM_005320	HIST1H1D	Histone 1, H1d	3.30127345
NM_003516	HIST2H2AA	Histone 2, H2aa	3.052311773
F02250	HDAC2	Histone deacetylase 2	2.559211106
NM_004739	MTA2	Metastasis associated 1 family, member 2	2.439100864
BC042589	HIST1H2BD	Histone 1, H2bd	2.361377538
CB529694	HIST2H2BE	Histone 2, H2be	2.358417445
AK126154	NP	Nucleoside phosphorylase	2.252382538
AB040899	KIAA1466	KIAA1466 gene	2.150614231
CR608156	HIST1H2AC	Histone 1, H2ac	1.894716468
BX436525	HIST1H2BH	Histone 1, H2bh	1.564280897
(m) 지질 대사(Lipid metabolism)
AK057762	TDH	L-threonine dehydrogenase	12.35436994
BC035124	UNQ2541	MSFL2541	11.28144368
BC034763	FDXR	Ferredoxin reductase	9.626878353
AK093461	ISYNA1	Myo-inositol 1-phosphate synthase A1	8.506076027
AK097009	PLTP	phospholipid transfer protein	6.838113748
AF524864	AKR1B10	Aldo-keto reductase family 1, member B10(aldose reductase)	5.170205623
NM_021727	FADS3	Fatty acid desaturase 3	4.914325733
CR627415	HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	3.576157214
CD013987	CYP21A2	Cytochrome P450, family 21, subfamily A, polypeptide 2	3.499529399
BC020744	AKR1C4	Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	3.073709856
NM_004753	DHRS3	Dehydrogenase/reductase (SDR family) member 3	2.952592956
BC030207	NR0B2	Nuclear receptor subfamily 0, group B, member 2	2.923794075
AK091948	LTB4DH	Leukotriene B4 12-hydroxydehydrogenase	2.915047859
NM_002900	RBP3	Retinol binding protein 3, interstitial	2.882318017
BX647927	PLCD1	Phospholipase C, delta 1	2.79125248
NM_145323	OSBPL3	Oxysterol binding protein-like 3	2.683653218
NM_000169	GLA	Galactosidase, alpha	2.640805113
BC094756	CRA	Myotubularin related protein 11	2.621196547
AB043587	ACBD3	Acyl-Coenzyme A binding domain containing 3	2.387297906
NM_001478	GALGT	UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)	2.371502969
J05428	UGT2B7	UDP glucuronosyltransferase 2 family, polypeptide B7	2.29241428
AB002454	CYP4F3	Cytochrome P450, family 4, subfamily F, polypeptide 3	2.282463636
NM_000405	GM2A	GM2 ganglioside activator	2.078054404
BC001823	PRKAB1	Protein kinase, AMP-activated, beta 1 non-catalytic subunit	2.069992917
NM_145343	APOL1	Apolipoprotein L, 1	2.065071129
NM_006571	DCTN6	Dynactin 6	2.032649122
NM_020139	DHRS6	Dehydrogenase/reductase (SDR family) member 6	2.017235349
(n) 금속 결합(Metal-binding)
NM_000499	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	88.34463354
BC007003	TGM4	Transglutaminase 4 (prostate)	24.06656282
NM_012189	CABYR	Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)	15.7546354
CR615530	CYGB	Cytoglobin	5.509895512
NM_004199	P4HA2	Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II	4.763879118
AK027560	CYP26A1	Cytochrome P450, family 26, subfamily A, polypeptide 1	4.292062656
NM_145298	APOBEC3F	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F	4.282991592
NM_005576	LOXL1	Lysyl oxidase-like 1	3.991893457
AK024854	APOBEC3B	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)	3.958267305
NM_014301	NIFUN	NifU-like N-terminal domain containing	3.922562485
BF670653	MB	Myoglobin	3.907590399
AK126982	LHX6	LIM homeobox 6	3.753938819
Y13786	ADAM19	ADAM metallopeptidase domain 19(meltrin beta)	3.418775374
AB051455	MICAL-L1	MICAL-like 1	3.221168592
AK074068	MICAL-L2	MICAL-like 2	3.121829223
AK124421	CPA1	Carboxypeptidase A1 (pancreatic)	3.111462293
NM_030622	CYP2S1	Cytochrome P450, family 2, subfamily S, polypeptide 1	2.768815748
BC012027	CYP2U1	Cytochrome P450, family 2, subfamily U, polypeptide 1	2.36896757
AY461717	ZNF385	Zinc finger protein 385	20.23244477
AK092424	ZSCAN4	Zinc finger and SCAN domain containing 4	17.62610589
AB208935	RASAL1	RAS protein activator like 1(GAP1 like)	13.22811232
NM_201444	DGKA	Diacylglycerol kinase, alpha 80kDa	6.831831283
BC035625	EGR2	Early growth response 2(Krox-20 homolog, Drosophila)	5.012409534
BF983391	RPS27L	Ribosomal protein S27-like	4.896252688
BC036545	PLAC2	Placenta-specific 2	4.739700637
BC034569	ZNF337	Zinc finger protein 337	4.082511332
CR936707	TRIM38	Tripartite motif-containing 38	3.756338118
AK091940	MGC4734	Ring finger protein 183	3.644058609
NM_024101	MLPH	Melanophilin	3.369249376
CR601823	HIVEP3	Human immunodeficiency virus type I enhancer binding protein 3	3.290777497
BC041578	MGC17986	zinc finger protein 114	3.166948191
BC038432	RARA	Retinoic acid receptor, alpha	2.87080107
(o) 전달(Transport)
BX641053	FXYD2	FXYD domain containing ion transport regulator 2	14.84364998
AK095363	AQP3	Aquaporin 3	8.623096731
AK074100	SLC37A2	Solute carrier family 37(glycerol-3-phosphate transporter), member 2	8.471999196
AK024002	TUBA4	Tubulin, alpha 4	7.427767363
AK092677	TUBB6	Tubulin, beta 6	6.458458484
NM_001297	CNGB1	Cyclic nucleotide gated channel beta 1	5.653120818
NM_032872	SYTL1	Synaptotagmin-like 1	4.930987441
NM_014045	LRP10	Low density lipoprotein receptor-related protein 10	4.616793009
NM_014585	SLC40A1	Solute carrier family 40(iron-regulated transporter), member 1	4.60980312
L02870	COL7A1	Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)	4.294284493
AK054731	TUBA1	Tubulin, alpha 1 (testis specific)	4.193322321
AF336127	SLC4A11	Solute carrier family 4, sodium bicarbonate transporter-like, member 11	4.116663762
AB075951	SLC22A2	Solute carrier family 22(organic cation transporter), member 2	3.98434766
AK125026	SLC6A12	Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12	3.756467829
BX537541	MGC13186	Chromosome 1 open reading frame 57	3.712498811
CD013956	SHBG	Sex hormone-binding globulin	3.685973664
BC029057	DAO	D-amino-acid oxidase	3.657991139
BC041479	COL9A2	Collagen, type IX, alpha 2	3.573628765
AL050210	LOC283130	Hypothetical protein LOC283130	3.265255922
NM_004798	KIF3B	Kinesin family member 3B	3.214670618
AK025742	UCP2	Uncoupling protein 2 (mitochondrial, proton carrier)	3.187327318
NM_021990	GABRE	Gamma-aminobutyric acid(GABA) A receptor, epsilon	3.110885736
NM_005819	STX6	Syntaxin 6	3.089406302
BC092420	CYP4F11	Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)	3.048152378
BC043423	ABCB6	ATP-binding cassette, sub-family B(MDR/TAP), member 6	3.039132233
BC021025	CTHRC1	Collagen triple helix repeat containing 1	3.022775957
NM_004999	MYO6	Myosin VI	3.020625421
AF445025	SLC35A4	Solute carrier family 35, member A4	3.018853063
NM_003330	TXNRD1	Thioredoxin reductase 1	2.810879753
AK092512	SLC16A5	Solute carrier family 16(monocarboxylic acid transporters), member 5	2.5780312
AB075871	FLJ42654	Golgi transport 1 homolog A(S. cerevisiae)	2.278893633
(p) 기타(The others)
NM_004864	GDF15	Growth differentiation factor 15	6.654247181
NM_022153	PP2135	Chromosome 10 open reading frame 54	6.333855415
NM_001013632	LOC343521	Similar to hypothetical protein 4833401D15	5.344247617
AK124751	CAPN2	Calpain 2,(m/II) large subunit	4.877328363
AK095079	RGC32	Response gene to complement 32	3.2942944
NM_031286	SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	2.915143493
AK126182	KIAA1949	KIAA1949	2.807348634
NM_080388	S100A16	S100 calcium binding protein A16	2.607982075
NM_025106	SSB1	SplA/ryanodine receptor domain and SOCS box containing 1	2.522542864
NM_203403	C9orf150	Chromosome 9 open reading frame 150	2.200130419
AK096241	SQSTM1	Sequestosome 1	2.015574807
BQ276852	TMSB10	Thymosin, beta 10	1.863965907
BC101655	HIST1H2BI	Histone 1, H2bi	1.863164701
W84524	TM4SF5	Transmembrane 4 L six family member 5	1.768210846
BX647290	HIST1H2BO	Histone 1, H2bo	1.511861325

크라이센에 의해 발현이 감소하는 유전자

등록번호	유전자약어	유전자명	중간값의비
(a) MAPKinase 신호 경로(MAPKinase Signaling Pathway)
NM_002467	MYC	V-myc myelocytomatosis viral oncogene homolog(avian)	0.153957027
BC038295	MAP2K7	Mitogen-activated protein kinase kinase 7	0.250015644
NM_004364	CEBPA	CCAAT/enhancer binding protein(C/EBP), alpha	0.291022284
NM_145161	MAP2K5	Mitogen-activated protein kinase kinase 5	0.396692291
XM_042066	MAP3K1	Mitogen-activated protein kinase kinase kinase 1	0.424190161
Z25424	MKNK2	MAP kinase interacting serine/threonine kinase 2	0.440953544
AB209047	ELK1	ELK1, member of ETS oncogene family	0.46931591
NM_004755	RPS6KA5	Ribosomal protein S6 kinase, 90kDa, polypeptide 5	0.486533941
AB001872	RPL4	Mitogen-activated protein kinase kinase kinase 13	0.488828813
NM_002758	MAP2K6	Mitogen-activated protein kinase kinase 6	0.489648933
AK098095	BRAF	V-raf murine sarcoma viral oncogene homolog B1	0.490796917
(b) MAPKKK 캐스케이드(MAPKKK cascade)
AB208919	FGFR1	Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)	0.306072231
BC060837	DUSP9	Dual specificity phosphatase 9	0.309017123
NM_000142	FGFR3	Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)	0.316732251
AY247738	TRIB3	Tribbles homolog 3 (Drosophila)	0.319013779
NM_030640	DUSP16	Dual specificity phosphatase 16	0.346335506
NM_148957	TNFRSF19	Tumor necrosis factor receptor superfamily, member 19	0.373948519
AB011123	TNIK	TRAF2 and NCK interacting kinase	0.375429687
NM_006549	CAMKK2	Calcium/calmodulin-dependent protein kinase kinase 2, beta	0.375436076
NM_022740	HIPK2	Homeodomain interacting protein kinase 2	0.491170791
(c) 아팝토시스(Apoptosis)
NM_005400	PRKCE	Protein kinase C, epsilon	0.110495908
NM_000893	KNG1	Kininogen 1	0.123179781
NM_000066	C8B	Complement component 8, beta polypeptide	0.168259363
CR749293	PLG	Plasminogen	0.214468702
BC013780	ADORA2A	Adenosine A2a receptor	0.25462881
NM_001012271	BIRC5	Effector cell peptidase receptor 1	0.261340346
NM_003811	TNFSF9	Tumor necrosis factor (ligand) superfamily, member 9	0.278995394
BC050369	E2F1	E2F transcription factor 1	0.284336508
NM_007313	ABL1	V-abl Abelson murine leukemia viral oncogene homolog 1	0.286557271
BX647151	MYBL2	V-myb myeloblastosis viral oncogene homolog(avian)-like 2	0.292335923
NM_004822	NTN1	Netrin 1	0.298168066
BC033694	BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.334908167
AB208876	AXIN1	Axin 1	0.346768268
BC051332	F2	Coagulation factor II (thrombin)	0.347828025
AK122614	PPARD	Peroxisome proliferative activated receptor, delta	0.348064401
L78790	ITGB2	Integrin, beta 2 (antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)	0.377717722
AK223409	BARD1	BRCA1 associated RING domain 1	0.385577392
NM_002737	PRKCA	Protein kinase C, alpha	0.38570547
NM_012479	YWHAG	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.38743105
CR596268	ITGB3BP	Integrin beta 3 binding protein(beta3-endonexin)	0.392340911
NM_003551	NME5	Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)	0.397002326
NM_013974	DDAH2	Dimethylarginine dimethylaminohydrolase 2	0.397010628
D79987	ESPL1	Extra spindle poles like 1(S. cerevisiae)	0.397660686
NM_006427	SIVA	CD27-binding(Siva) protein	0.399556277
NM_024900	PHF17	PHD finger protein 17	0.400845508
AB046854	MAGI-3	Membrane associated guanylate kinase, WW and PDZ domain containing 3	0.423418754
AK095578	SPHK1	Sphingosine kinase 1	0.442516388
AK122762	CIDEA	Cell death-inducing DFFA-like effector a	0.448550433
AK092872	ERCC2	Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)	0.448557114
NM_006290	TNFAIP3	Tumor necrosis factor, alpha-induced protein 3	0.452157996
NM_000562	C8A	Complement component 8, alpha polypeptide	0.463461593
AK122894	AKT1	V-akt murine thymoma viral oncogene homolog 1	0.467334939
NM_005067	SIAH2	Seven in absentia homolog 2(Drosophila)	0.467840694
NM_203339	CLU	Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)	0.469884724
NM_003376	VEGF	Vascular endothelial growth factor	0.481416264
AK027590	DAPK3	Death-associated protein kinase 3	0.48390449
AK122825	HMGB1	High-mobility group box 1	0.505043422
(d) DNA 손상에 대한 반응(Response to DNA damage stimulus)
NM_006904	PRKDC	Protein kinase, DNA-activated, catalytic polypeptide	0.136872821
AK074377	UHRF1	Chromosome 19 open reading frame 31	0.162554272
CR604810	CCNA2	Cyclin A2	0.271739971
AK001720	FLJ10858	Nei endonuclease VIII-like 3(E. coli)	0.272320034
CR600021	HMGB2	High-mobility group box 2	0.292500615
NM_006230	POLD2	Polymerase(DNA directed), delta 2, regulatory subunit 50kDa	0.296598073
NM_018151	RIF1	RAP1 interacting factor homolog(yeast)	0.337901829
BX248766	RAD51L1	RAD51-like 1(S. cerevisiae)	0.35239904
NM_014502	PRP19	PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)	0.352412499
NM_013975	LIG3	Ligase III, DNA, ATP-dependent	0.366235708
NM_173627	FLJ35220	Hypothetical protein FLJ35220	0.370187726
NM_003362	UNG	Uracil-DNA glycosylase	0.378408018
AF076494	IRF7	Interferon regulatory factor 7	0.385612995
CR625391	RAD51AP1	RAD51 associated protein 1	0.391222632
NM_006231	POLE	Polymerase(DNA directed), epsilon	0.394826988
NM_130398	EXO1	Exonuclease 1	0.407524268
DQ140356	KIAA1596	Fanconi anemia, complementation group M	0.412353616
NM_002105	H2AFX	H2A histone family, member X	0.41455303
AB209560	POLD1	Polymerase(DNA directed), delta 1, catalytic subunit 125kDa	0.443656469
NM_000136	FANCC	Fanconi anemia, complementation group C	0.444998791
NM_003368	USP1	Ubiquitin specific peptidase 1	0.445903079
NM_022836	DCLRE1B	DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)	0.446832858
NM_001067	TOP2A	Topoisomerase(DNA) II alpha 170kDa	0.450120675
NM_002913	RFC1	Replication factor C (activator 1) 1, 145kDa	0.471937101
NM_002412	MGMT	O-6-methylguanine-DNA methyltransferase	0.492152777
NM_000251	MSH2	MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)	0.582053356
(e) 면역 반응(Immune response)
NM_015254	KIF13B	Kinesin family member 13B	0.20677975
NM_006037	HDAC4	Histone deacetylase 4	0.233288586
NM_020995	HPR	Haptoglobin-related protein	0.242867738
NM_153443	KIR3DL1	Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	0.281426014
BC071718	CCL4L1	Chemokine(C-C motif) ligand 4-like 1	0.294604522
NM_020979	APS	Adaptor protein with pleckstrin homology and src homology 2 domains	0.29487541
NM_001629	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein	0.300419669
NM_130852	PLUNC	Palate, lung and nasal epithelium carcinoma associated	0.320441751
AK024499	SPON2	Spondin 2, extracellular matrix protein	0.328221638
BC048198	AHSG	Alpha-2-HS-glycoprotein	0.344058212
AK095849	RNU22	RNA, U22 small nucleolar	0.353888139
BC005395	HPX	Hemopexin	0.367891973
NM_012276	ILT7	Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4	0.392427034
NM_003152	STAT5A	Signal transducer and activator of transcription 5A	0.400291045
BC037171	CCL27	Chemokine(C-C motif) ligand 27	0.40075022
NM_002468	MYD88	Myeloid differentiation primary response gene(88)	0.403137375
NM_002215	ITIH1	Inter-alpha (globulin) inhibitor H1	0.405944172
NM_004750	CRLF1	Cytokine receptor-like factor 1	0.413787497
DR004094	HAMP	Hepcidin antimicrobial peptide	0.413938464
BC063245	GNLY	Granulysin	0.422712087
AJ290445	SARM1	Sterile alpha and TIR motif containing 1	0.430080233
AK122686	IF	I factor(complement)	0.436309666
AB008535	GPR44	G protein-coupled receptor 44	0.440552612
AK122912	ZGPAT	Zinc finger, CCCH-type with G patch domain	0.44067651
BC022312	C4BPA	Complement component 4 binding protein, alpha	0.442950052
BG564683	ORM1	Orosomucoid 1	0.445506981
NM_000625	NOS2A	Nitric oxide synthase 2A(inducible, hepatocytes)	0.460550527
NM_005515	HLXB9	Homeo box HB9	0.467040193
BX537504	C2	Complement component 2	0.484853058
BC028153	LILRB3	Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3	0.490534341
AF130100	SERPINC1	Serpin peptidase inhibitor, clade C(antithrombin), member 1	0.491818077
BC015110	HHEX	Hematopoietically expressed homeobox	0.602852309
(f) 유사분열 세포주기(Mitotic cell cycle)
AB209179	PLK1	Polo-like kinase 1 (Drosophila)	0.120946155
AY367065	ASPM	Asp(abnormal spindle)-like, microcephaly associated(Drosophila)	0.186885667
NM_006101	KNTC2	Kinetochore associated 2	0.257114298
NM_003550	MAD1L1	MAD1 mitotic arrest deficient-like 1(yeast)	0.268688634
NM_020242	KNSL7	Kinesin family member 15	0.280736071
AB033068	FZR1	Fizzy/cell division cycle 20 related 1(Drosophila)	0.281781782
NM_018492	PBK	PDZ binding kinase	0.284074566
NM_003318	TTK	TTK protein kinase	0.3026269
BC011000	CDCA5	Cell division cycle associated 5	0.31212201
NM_003981	PRC1	Protein regulator of cytokinesis 1	0.313872555
NM_015097	CLASP2	Cytoplasmic linker associated protein 2	0.336054596
U65410	MAD2L1	MAD2 mitotic arrest deficient-like 1(yeast)	0.34214776
NM_016343	CENPF	Centromere protein F, 350/400ka(mitosin)	0.344911485
NM_005504	BCAT1	Branched chain aminotransferase 1, cytosolic	0.345858236
NM_003718	CDC2L5	Cell division cycle 2-like 5(cholinesterase-related cell division controller)	0.354681271
NM_002768	PCOLN3	Procollagen(type III) N-endopeptidase	0.389132906
BC004352	KIF22	Kinesin family member 22	0.391492074
NM_005983	SKP2	S-phase kinase-associated protein 2(p45)	0.39153455
NM_004523	KIF11	Kinesin family member 11	0.421587881
CR592757	BRRN1	Barren homolog 1 (Drosophila)	0.430159766
NM_019063	EML4	Echinoderm microtubule associated protein like 4	0.434736842
NM_006845	KIF2C	Kinesin family member 2C	0.43971662
NM_004701	CCNB2	Cyclin B2	0.442694391
NM_138555	KIF23	Kinesin family member 23	0.449014129
NM_182687	PKMYT1	Protein kinase, membrane associated tyrosine/threonine 1	0.452437142
NM_001790	CDC25C	Cell division cycle 25C	0.460379159
BC032677	UBE2C	Ubiquitin-conjugating enzyme E2C	0.462505602
NM_005886	KATNB1	Katanin p80(WD repeat containing) subunit B 1	0.464765241
BC073878	KIFC1	Kinesin family member C1	0.481322258
AL833191	SMC2L1	SMC2 structural maintenance of chromosomes 2-like 1(yeast)	0.486060683
AF053305	BUB1	BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)	0.491236752
Z25431	NEK1	NIMA(never in mitosis gene a)-related kinase 1	0.49168642
BC043371	GFI1B	Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)	0.494495314
CR933728	CDC2	Cell division cycle 2, G1 to S and G2 to M	0.496459108
NM_014750	DLG7	Discs, large homolog 7(Drosophila)	0.580070458
(g) 세포 주기(Cell cycle)
NM_018560	WWOX	WW domain containing oxidoreductase	0.079825512
BG203702	FHIT	Nasopharyngeal carcinoma, down-regulated 1	0.093083555
BC050384	SUPT3H	Suppressor of Ty 3 homolog(S. cerevisiae)	0.126706068
NM_000189	HK2	Hexokinase 2	0.173385257
CD049340	AURKB	Aurora kinase B	0.19031938
AB011153	PLCB1	Phospholipase C, beta 1(phosphoinositide-specific)	0.215552494
AB209271	ERF	Ets2 repressor factor	0.232018189
NM_014264	PLK4	Polo-like kinase 4 (Drosophila)	0.247388103
NM_002417	MKI67	Antigen identified by monoclonal antibody Ki-67	0.258796008
XM_496557	RGP1	Plasminogen-like B2	0.294326139
NM_170715	RASSF1	Ras association (RalGDS/AF-6) domain family 1	0.298232376
NM_004526	MCM2	MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)	0.302992712
BC033086	TCF19	Transcription factor 19(SC1)	0.32373718
NM_001007071	RPS6KB2	Ribosomal protein S6 kinase, 70kDa, polypeptide 2	0.324307585
NM_016272	TOB2	Transducer of ERBB2, 2	0.330193495
AK126688	CDYL2	Chromodomain protein, Y-like 2	0.387113875
NM_001759	CCND2	Cyclin D2	0.389524403
NM_002388	MCM3	MCM3 minichromosome maintenance deficient 3(S. cerevisiae)	0.398257469
NM_182776	MCM7	MCM7 minichromosome maintenance deficient 7(S. cerevisiae)	0.404714589
NM_012145	DTYMK	Deoxythymidylate kinase(thymidylate kinase)	0.423208336
NM_014751	MTSS1	Metastasis suppressor 1	0.43748772
NM_024342	GRLF1	Glucocorticoid receptor DNA binding factor 1	0.442555888
AK025627	CABLES1	Cdk5 and Abl enzyme substrate 1	0.471323938
NM_005915	MCM6	MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)	0.472089288
AF196185	PARD3	Par-3 partitioning defective 3 homolog(C. elegans)	0.484933312
NM_019001	XRN1	5'-3' exoribonuclease 1	0.488883063
NM_006739	MCM5	MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)	0.491549947
NM_012218	ILF3	Interleukin enhancer binding factor 3, 90kDa	0.492503876
AB053172	CDT1	DNA replication factor	0.493969454
AK074112	CCNL2	Cyclin L2	0.498469976
NM_001005414	ZWINT	ZW10 interactor antisense	0.584517014
(h) 알코올 대사(Alcohol metabolism)
BC033391	PP1665	Glycerophosphodiester phosphodiesterase domain containing 5	0.215800503
NM_000672	ADH6	Alcohol dehydrogenase 6(class V)	0.271123842
NM_004563	PCK2	Phosphoenolpyruvate carboxykinase 2(mitochondrial)	0.337047159
XM_113962	KIAA0650	Structural maintenance of chromosomes flexible hinge domain containing 1	0.348581608
NM_001500	GMDS	GDP-mannose 4,6-dehydratase	0.354747755
NM_002541	OGDH	Oxoglutarate (alpha-ketoglutarate) dehydrogenase(lipoamide)	0.357289949
NM_000298	PKLR	Pyruvate kinase, liver and RBC	0.39231759
NM_005276	GPD1	Glycerol-3-phosphate dehydrogenase 1(soluble)	0.394511398
AB209127	PFKL	Phosphofructokinase, liver	0.396666891
M15943	ADH4	Alcohol dehydrogenase 4(class II), pi polypeptide	0.441308466
NM_000671	ADH5	Alcohol dehydrogenase 5(class III), chi polypeptide	0.448054959
BC026320	OGDHL	Oxoglutarate dehydrogenase-like	0.464556343
NM_009590	AOC2	Amine oxidase, copper containing 2(retina-specific)	0.479506902
BC015797	SLC25A10	Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10	0.489192347
(i) 아미노산 대사(Amino acid metabolism)
NM_003748	ALDH4A1	Aldehyde dehydrogenase 4 family, member A1	0.179005599
NM_002108	HAL	Histidine ammonia-lyase	0.19694868
NM_003486	SLC7A5	Solute carrier family 7(cationic amino acid transporter, y+ system), member 5	0.201120723
NM_003045	SLC7A1	Solute carrier family 7(cationic amino acid transporter, y+ system), member 1	0.204215808
NM_000277	PAH	Phenylalanine hydroxylase	0.207720611
NM_012331	MSRA	Methionine sulfoxide reductase A	0.21152792
BC008366	DDC	Dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.219970928
NM_006567	FARS2	Phenylalanine-tRNA synthetase 2(mitochondrial)	0.242735735
AK055862	FLJ31300	Urocanase domain containing 1	0.265306391
NM_001875	CPS1	Carbamoyl-phosphate synthetase 1, mitochondrial	0.284603831
AK122685	GLUD1	Glutamate dehydrogenase 1	0.290594908
NM_003046	SLC7A2	Solute carrier family 7(cationic amino acid transporter, y+ system), member 2	0.303490377
AK093306	PHGDH	Phosphoglycerate dehydrogenase	0.315789771
NM_080820	HARS2	Histidyl-tRNA synthetase 2	0.337699715
NM_006907	PYCR1	Pyrroline-5-carboxylate reductase 1	0.343360051
NM_020117	LARS	Leucyl-tRNA synthetase	0.359457546
BC051726	GLUL	Glutamate-ammonia ligase(glutamine synthetase)	0.363765571
BC012616	BHMT	Betaine-homocysteine methyltransferase	0.369989797
AK055053	SHMT2	Serine hydroxymethyltransferase 2(mitochondrial)	0.401235464
NM_007101	SARDH	Sarcosine dehydrogenase	0.402864636
AL833251	LOC283970	Hypothetical protein LOC283970	0.40730291
AK027126	ASS	Argininosuccinate synthetase	0.418690738
L00972	CBS	Cystathionine-beta-synthase	0.440354778
NM_206965	FTCD	Formiminotransferase cyclodeaminase	0.47079397
NM_000429	MAT1A	Methionine adenosyltransferase I, alpha	0.472559543
NM_001801	CDO1	Cysteine dioxygenase, type I	0.480848737
NM_006843	SDS	Serine dehydratase	0.488304529
NM_000170	GLDC	Glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P)	0.491686799
(j) DNA 대사(DNA metabolism)
BX102654	HIST1H4B	Histone 1, H4b	0.172360533
DQ097177	UREB1	HECT, UBA and WWE domain containing 1	0.213344474
NM_022743	SMYD3	SET and MYND domain containing 3	0.265102932
NM_001809	CENPA	Centromere protein A, 17kDa	0.272224677
AB028450	NCOR1	Nuclear receptor co-repressor 1	0.31777205
NM_002967	SAFB	Scaffold attachment factor B	0.3219512
NM_003074	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.353538227
NM_015409	EP400	E1A binding protein p400	0.371543731
BC044659	SMARCA3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3	0.393689415
AB209433	BAT8	Euchromatic histone-lysine N-methyltransferase 2	0.398851055
XM_370756	KIAA1305	KIAA1305	0.41059832
NM_020201	NT5M	5',3'-nucleotidase, mitochondrial	0.425450039
NM_001025248	DUT	DUTP pyrophosphatase	0.4301363
AK123010	RRM2	Ribonucleotide reductase M2 polypeptide	0.443733966
BX537961	DNMT2	DNA (cytosine-5-)-methyltransferase 2	0.449895729
BX648935	TBL1XR1	Transducin (beta)-like 1X-linked receptor 1	0.45144224
NM_001001888	VCX-C	Variably charged X-C	0.451813598
NM_002501	NFIX	Nuclear factor I/X (CCAAT-binding transcription factor)	0.455473267
NM_003483	HMGA2	High mobility group AT-hook 2	0.45812854
U80628	TK2	Thymidine kinase 2, mitochondrial	0.460005269
NM_006807	CBX1	Chromobox homolog 1 (HP1 beta homolog Drosophila )	0.46081477
AY024361	MLL3	Myeloid/lymphoid or mixed-lineage leukemia 3	0.461050924
NM_017519	ARID1B	AT rich interactive domain 1B(SWI1-like)	0.46115551
NM_003077	SMARCD2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	0.461333882
NM_016937	POLA	Polymerase(DNA directed), alpha	0.463508595
(k) 지질 대사(Lipid metabolism)
AJ007583	LARGE	Like-glycosyltransferase	0.142759166
AK124635	PCSK9	Proprotein convertase subtilisin/kexin type 9	0.146781198
NM_030758	OSBP2	Oxysterol binding protein 2	0.148618668
NM_005063	SCD	Stearoyl-CoA desaturase(delta-9-desaturase)	0.16572839
NM_000236	LIPC	Lipase, hepatic	0.198492731
AF288389	GLT25D2	Glycosyltransferase 25 domain containing 2	0.198600514
AF202889	APOA5	Apolipoprotein A-V	0.209911653
BX640945	FADS2	Fatty acid desaturase 2	0.213145374
BI521580	APOC3	Apolipoprotein C-III	0.23320201
NM_001277	CHKA	Choline kinase alpha	0.244381018
Z28339	AKR1D1	Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)	0.254902416
BC035654	NR1H4	Nuclear receptor subfamily 1, group H, member 4	0.262741172
AB209229	MVD	Mevalonate (diphospho) decarboxylase	0.269846903
BC026264	UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.271647964
NM_004104	FASN	Fatty acid synthase	0.280448461
NM_147161	THEA	Acyl-CoA thioesterase 11	0.285998121
AF059203	SOAT2	Sterol O-acyltransferase 2	0.288070163
NM_020918	GPAM	Glycerol-3-phosphate acyltransferase, mitochondrial	0.292909604
NM_001443	FABP1	Fatty acid binding protein 1, liver	0.296451689
NM_014762	DHCR24	24-dehydrocholesterol reductase	0.297972079
AK093328	PCYT2	Phosphate cytidylyltransferase 2, ethanolamine	0.311874518
BX538214	C6orf167	Chromosome 6 open reading frame 167	0.323543551
X75311	MVK	Mevalonate kinase (mevalonic aciduria)	0.333966231
NM_000497	CYP11B1	Cytochrome P450, family 11, subfamily B, polypeptide 1	0.338436304
BC036102	SIAT7F	ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	0.34576685
BC012172	ACAS2	Acyl-CoA synthetase short-chain family member 2	0.350569281
NM_007169	PEMT	Phosphatidylethanolamine N-methyltransferase	0.356048412
X91148	MTP	Microsomal triglyceride transfer protein	0.362753622
NM_198839	ACACA	Acetyl-Coenzyme A carboxylase alpha	0.380784496
NM_004687	MTMR4	Myotubularin related protein 4	0.401837935
NM_000384	APOB	Apolipoprotein B (including Ag(x) antigen)	0.416233282
AK127051	ACAA1	Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)	0.423299321
BC035638	LSS	Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.430665775
NM_004204	PIGQ	Phosphatidylinositol glycan, class Q	0.45218399
NM_004457	ACSL3	Acyl-CoA synthetase long-chain family member 3	0.454938664
AL138578	ADPN	Adiponutrin	0.461837251
NM_002332	LRP1	Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)	0.468691544
NM_016372	GPR175	G protein-coupled receptor 175	0.479022743
NM_080476	CDC91L1	CDC91 cell division cycle 91-like 1(S. cerevisiae)	0.479354103
AF303134	ALDH8A1	Aldehyde dehydrogenase 8 family, member A1	0.481811965
NM_002130	HMGCS1	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)	0.483678121
AK055414	LASS4	LAG1 longevity assurance homolog 4(S. cerevisiae)	0.485211697
NM_022977	ACSL4	Acyl-CoA synthetase long-chain family member 4	0.485591269
NM_004631	LRP8	Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.490795611
NM_002573	PAFAH1B3	Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa	0.495601801
NM_021005	NR2F2	Nuclear receptor subfamily 2, group F, member 2	0.497299707
(l) 금속 결합(Metal-binding)
CR620135	DPEP1	Dipeptidase 1(renal)	0.190430174
NM_002317	LOX	Lysyl oxidase	0.198239785
NM_005949	MT1F	Metallothionein 1F (functional)	0.22405551
AF279145	ANTXR1	Anthrax toxin receptor 1	0.230840625
NM_005588	MEP1A	Meprin A, alpha(PABA peptide hydrolase)	0.259485084
NM_014214	IMPA2	Inositol(myo)-1(or 4)-monophosphatase 2	0.263186701
NM_005940	MMP11	Matrix metallopeptidase 11(stromelysin 3)	0.264566247
AB193259	ACE2	Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2	0.273758292
AF018081	COL18A1	Collagen, type XVIII, alpha 1	0.291828069
M28016	cytochrome b	Human mitochondrial cytochrome b gene, partial cds.	0.297761706
NM_002428	MMP15	Matrix metallopeptidase 15(membrane-inserted)	0.31207988
NM_025074	FRAS1	Fraser syndrome 1	0.33237663
M75106	CPB2	Carboxypeptidase B2 (plasma, carboxypeptidase U)	0.614512721
NM_000937	POLR2A	Polymerase(RNA) II (DNA directed) polypeptide A, 220kDa	0.204681289
NM_005060	RORC	RAR-related orphan receptor C	0.221567885
BC092512	MYRIP	Myosin VIIA and Rab interacting protein	0.248675106
NM_000901	NR3C2	Nuclear receptor subfamily 3, group C, member 2	0.266066448
NM_005392	PHF2	PHD finger protein 2	0.268831722
AK091289	ZNF367	Zinc finger protein 367	0.275012045
NM_014788	TRIM14	Tripartite motif-containing 14	0.276556442
NM_018660	ZNF395	Zinc finger protein 395	0.296616246
AB209755	MLLT10	Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10	0.300538557
AK097472	MAZ	MYC-associated zinc finger protein(purine-binding transcription factor)	0.313722345
NM_020062	SLC2A4RG	SLC2A4 regulator	0.33059257
BX571750	HNF4G	Hepatocyte nuclear factor 4, gamma	0.332470234
(m) 전달(Transport)
NM_021807	SEC8L1	Exocyst complex component 4	0.089545841
NM_006651	CPLX1	Complexin 1	0.131109907
NM_005845	ABCC4	ATP-binding cassette, sub-family C(CFTR/MRP), member 4	0.133334881
NM_006650	CPLX2	Complexin 2	0.134012051
NM_004164	RBP2	Retinol binding protein 2, cellular	0.156673775
NM_021069	ARGBP2	Sorbin and SH3 domain containing 2	0.166678886
NM_201649	SLC6A9	Solute carrier family 6(neurotransmitter transporter, glycine), member 9	0.214191554
NM_005835	SLC17A2	Solute carrier family 17(sodium phosphate), member 2	0.221982855
AJ315644	SLC2A13	Solute carrier family 2(facilitated glucose transporter), member 13	0.222684082
NM_000340	SLC2A2	Solute carrier family 2(facilitated glucose transporter), member 2	0.227123291
NM_003685	KHSRP	KH-type splicing regulatory protein(FUSE binding protein 2)	0.22945097
BX537382	SLC38A3	Solute carrier family 38, member 3	0.242568721
NM_182964	NAV2	Neuron navigator 2	0.247250994
BX640965	SLC22A3	Solute carrier family 22(extraneuronal monoamine transporter), member 3	0.255608537
AK127255	SNX26	Sorting nexin 26	0.260176313
AY043484	SCN1A	Sodium channel, voltage-gated, type I, alpha	0.260866507
AK074107	C20orf59	Chromosome 20 open reading frame 59	0.271346073
NM_003056	SLC19A1	Solute carrier family 19(folate transporter), member 1	0.29688016
NM_020897	HCN3	Hyperpolarization activated cyclic nucleotide-gated potassium channel 3	0.313835834
AY124771	SLC26A1	Solute carrier family 26(sulfate transporter), member 1	0.317100952
NM_001011554	SLC13A3	Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3	0.321469735
AK027855	SLC5A6	Solute carrier family 5(sodium-dependent vitamin transporter), member 6	0.327464039
NM_001005747	CACNB4	Calcium channel, voltage-dependent, beta 4 subunit	0.332952777
NM_013277	RACGAP1	Rac GTPase activating protein 1	0.378143166
(n) 기타(The others)
NM_012340	NFATC2	Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.417449456
NM_018291	FLJ10986	Hypothetical protein FLJ10986	0.181870965
BC052951	LMNB1	Lamin B1	0.197126008
AK075271	SPTLC2L	Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)	0.230098147
BI762502	GSTA2	Glutathione S-transferase A2	0.31916011
AK055221	FBXO5	F-box protein 5	0.342113931
XM_372695	LOC390859	PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA	0.356013687
AB037805	KLHL14	Kelch-like 14 (Drosophila)	0.376251676
NM_145061	C13orf3	Chromosome 13 open reading frame 3	0.377419925
AK000643	ASB9	Ankyrin repeat and SOCS box-containing 9	0.419775956
AL133031	MLR1	Transcription factor MLR1	0.438551394
AB091343	C10orf3	Centrosomal protein 55kDa	0.451690933
AY007723	MAL2	Mal, T-cell differentiation protein 2	0.456188931
BC098313	FLJ20641	Hypothetical protein FLJ20641	0.508085568
BC041882	ATF7IP2	Activating transcription factor 7 interacting protein 2	0.521200373
AK127098	FLJ10706	Chromosome 1 open reading frame 112	0.527226934
BC022255	Spc25	Spindle pole body component 25 homolog(S. cerevisiae)	0.537391579
BC026283	APOH	Apolipoprotein H (beta-2-glycoprotein I)	0.650367241

<실시예 3> 실시간 RT-PCR(Real-time reverse transcriptase polymerase chain reaction) 정량

크라이센에 의해 발현 유도된 상기 실시예 2의 2배 이상 과발현 및 저발현된 유전자 중 크라이센에 의해 과발현되는 유전자 25종과 저발현 되는 유전자 10종을 선별하였다. 이들 유전자들은 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_004881(Tumor protein p53 inducible protein 3), 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_006426(Dihydropyrimidinase-like 4), 유전자 등록번호(Genebank) NM_133493[CD109 antigen(Gov platelet alloantigens)], 유전자 등록번호(Genebank) AB033073(Sulfatase 2), 유전자 등록번호(Genebank) NM_021603(FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AK097009(phospholipid transfer protein), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) BU587578(Regulator of G-protein signalling 10), 유전자 등록번호(Genebank) BQ683841[S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) NM_001013632[polo-like kinase 3(Drosophila)], 유전자 등록번호(Genebank) NM_032872(Synaptotagmin-like 1), 유전자 등록번호(Genebank) BC042390[Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000596(Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_005319(Histone 1, H1c), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769[CD9 antigen(p24)], 유전자 등록번호(Genebank) NM_001553(Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410[MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa) 및 유전자 등록번호(Genebank) BC022255[Spindle pole body component 25 homolog(S. cerevisiae)] 등이다.

상기 유전자들의 발현변화 정도를 조사 및 정량하기 위해 상기 유전자들의 mRNA를 특이적으로 발현할 수 있는 프라이머를 제작하여(표 4), My IQ 실시간 PCR(My IQ Real-time PCR)(Bio-rad, USA)을 이용하여 정량적인 실시간 RT-PCR을 실시하였다.

구체적으로, 올리고 dT 프라이머와 Superscript kit(Omniscipt™ kit, Qiagen, Co., USA)를 이용하여 역전사반응을 수행하여 cDNA를 합성하였다. PCR 산물을 정량하기 위하여 사이버그린(SYBR Green) I 염색(Bio-rad, USA)으로 염색하였다. 사이버그린 I 염색은 이중나선 DNA에 결합하는 염색법으로서, PCR 과정 동안 이중나선 DNA가 생성될수록 형광강도(fluroscense intensity)가 증가하게 된다. 먼저 PCR에 이용한 표적 유전자와 내재성(endogenous) 대조군(GAPDH)에 대한 프라이머를 사이버그린 마스터 믹스(Master mix)에 첨가하여 PCR을 실시한 후, 적절한 농도를 선택하는 프라이머 적합화(primer optimization) 과정을 수행하였다. 합성된 cDNA 시료와 각각의 프라이머(표 4)를 혼합하고, 사이버그린 마스터 믹스를 첨가한 후 PCR를 수행하였고, 정량 소프트웨어(software)를 사용하여 분석하였다.

등록번호	유전자명	PCR 프라이머 서열
NM_000499	Cytochrome P450, family 1, subfamily A, polypeptide 1	센스(서열번호1)	CACCATCCCCCACAGCAC
		안티센스(서열번호2)	ACAAAGACACAACGCCCCTT
BX649164	serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1	센스(서열번호3)	CAGACCAAGAGCCTCTCCAC
		안티센스(서열번호4)	ATCACTTGGCCCATGAAAAG
NM_004881	Tumor protein p53 inducible protein 3	센스(서열번호5)	AGGGTGAAGTCCTCCTGAAGGT
		안티센스(서열번호6)	GTGGGTCATACTGGCCTTGTCT
BM913048	TIMPmetallopeptidaseinhibitor1	센스(서열번호7)	GATACTTCCACAGGTCCCACAAC
		안티센스(서열번호8)	GCAAGAGTCCATCCTGCAGTT
NM_006426	Dihydropyrimidinase-like4	센스(서열번호9)	TGGGAAGATGGACGAGAATGAGTTCG
		안티센스(서열번호10)	ACTCCACTCCCTCGAAGATGTTGT
NM_133493	CD109 antigen(Gov platelet alloantigens)	센스(서열번호11)	GCCAAGATTTACCACGTTTGCCCA
		안티센스(서열번호12)	TGAAGGACCAGAACTGAGCCACAT
AB033073	Sulfatase 2	센스(서열번호13)	TGCGGATATGGACGGGAAATCCAT
		안티센스(서열번호14)	TCTCTTGTGTAGCAGCTTGCCTCT
NM_021603	FXYD domain containing ion transport regulator 2	센스(서열번호15)	GGCAATAAGAAGCGCAGGCAAATC
		안티센스(서열번호16)	AAGGTCTAAAGCCCAGGGAAGAAG
BC035124	MSFL2541	센스(서열번호17)	TTCGCCGTCCTTTACATCTAC
		안티센스(서열번호18)	AGAGCCTGGGGACTCACAT
Y11307	Cysteine-rich, angiogenic inducer, 61	센스(서열번호19)	ATTGTAGAAAGGAAGCCTTGCTCAT
		안티센스(서열번호20)	TCCAATCGTGGCTGCATTAG
AK095363	Aquaporin 3	센스(서열번호21)	TTCACGATCCACCCTTTCAGGCTA
		안티센스(서열번호22)	ACACATACCTGCTGCCCATTCTCT
AK097009	Phospholipid transfer protein	센스(서열번호23)	TGCCACAGAGAAGACGGGATTTGA
		안티센스(서열번호24)	AGGTGGTGGACGGACTGTAATTGA
NM_004864	Growth differentiation factor 15	센스(서열번호25)	CCTGAGACACCCGATTCCT
		안티센스(서열번호26)	ACAGTTCCATCAGACCAGCC
BU587578	Regulator of G-protein signalling 10	센스(서열번호27)	CCGTGCCGGGTTTATCATTGCTTT
		안티센스(서열번호28)	TCGACGTGTCCAGTGTTGAAGGAA
BQ683841	S100 calcium binding protein A11(calgizzarin)	센스(서열번호29)	AGTCCCTGATTGCTGTCTTCCAGA
		안티센스(서열번호30)	ACCAGGGTCCTTCTGGTTCTTTGT
NM_001013632	polo-like kinase 3 (Drosophila)	센스(서열번호31)	GACTACTCCAATAAGTTCGGCTTTG
		안티센스(서열번호32)	CATATGTGTGCCATCGTTGAAGA
NM_032872	Synaptotagmin-like 1	센스(서열번호33)	GGCGGTGAAGAAACGGAATCTGAA
		안티센스(서열번호34)	GAAAGATGTTGCGACCCAGGCTTT
BC042390	Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)	센스(서열번호35)	GGGGGACTAACCTATCGAGAA
		안티센스(서열번호36)	GATCCAGTGCTGATAGCAACC
NM_000596	Insulin-like growth factor binding protein 1	센스(서열번호37)	ATCATTCCATCCTTTGGGACGCCA
		안티센스(서열번호38)	TGTCTCCTGTGCCTTGGCTAAACT
NM_005319	Histone 1, H1c	센스(서열번호39)	ACCAAACCTAAGAAGCCAGTTG
		안티센스(서열번호40)	TAGCGCTCTTCTTCGGAGTT
AK094474	Ras homolog gene family, member C	센스(서열번호41)	ACCTGCCTCCTCATCGTCTTC
		안티센스(서열번호42)	CACCTGCTTGCCGTCCAC
NM_001769	CD9 antigen(p24)	센스(서열번호43)	GCACCAAGTGCATCAAATACCTGC
		안티센스(서열번호44)	AGCCATAGTCCAATGGCAAGGACA
NM_001553	Insulin-like growth factor binding protein 7	센스(서열번호45)	ACTTGAGCTGTGAGGTCATCGGAA
		안티센스(서열번호46)	ATACCAGCACCCAGCCAGTTACTT
NM_003897	Immediate early response 3	센스(서열번호47)	AGCCCTTTAATCTGACTTCGGAGC
		안티센스(서열번호48)	CAGGTACGCCTGGTGTTTCTTTGT
NM_003516	Histone 2, H2aa	센스(서열번호49)	GAACTGAACAAGCTGCTGGGCAAA
		안티센스(서열번호50)	TCTCCGTCTTCTTAGGGAGCAGTA
AK074377	Chromosome 19 open reading frame 31	센스(서열번호51)	CTGGTACGACGCGGAGAT
		안티센스(서열번호52)	CGACAGTCGTTCAGAGAATCA
BX640965	Solute carrier family 22(extraneuronal monoamine transporter), member 3	센스(서열번호53)	GCCCTGTTCCAGCAATAAGA
		안티센스(서열번호54)	GAGAGCCAAAAATGTCCCAA
NM_018492	PDZ binding kinase	센스(서열번호55)	TCTGGACTGAGAGTGGCTTTCACA
		안티센스(서열번호56)	AGCCAAGCTTCTGCATAAACGGAG
CR600021	High-mobility group box 2	센스(서열번호57)	CTTGGCACGATATGCAGCAA
		안티센스(서열번호58)	CAGCCAAAGATAAACAACCATATGA
NM_006101	Kinetochore associated 2	센스(서열번호59)	TGCTACACATGTTGGGTCTGTA
		안티센스(서열번호60)	CCGAGAGATCTTCTGACATGC
NM_003318	TTK protein kinase	센스(서열번호61)	TCATGCCCATTTGGAAGAGTCCCA
		안티센스(서열번호62)	AGGCACAACCAAATCTCGGCATTC
U65410	MAD2 mitotic arrest deficient-like 1(yeast)	센스(서열번호63)	ACTTAAATATCTCCCTACCTATACTGAGTCAA
		안티센스(서열번호64)	TAGTAACTGTAGATGGAAAAACTTGTGCTA
NM_001067	Topoisomerase(DNA) II alpha 170kDa	센스(서열번호65)	CTAGTTAATGCTGCGGACAACA
		안티센스(서열번호66)	CATTTCGACCACCTGTCACTT
AB091343	Centrosomal protein 55kDa	센스(서열번호67)	GCTGTGCATTTCTCTTGGCAGTGA
		안티센스(서열번호68)	TAGACGCTGCTCACCACATTCTGT
BC022255	Spindle pole body component 25 homolog(S. cerevisiae)	센스(서열번호69)	GAATGGTTGAGATGTTTCTGGA
		안티센스(서열번호70)	GCAATCAATTTTAACAAGTTATCCTTT

실시간 정량 PCR 결과

등록번호	유전자명	약어	마이크로어레이 (Cy3/Cy5 비율)	실시간 PCR(상대적 배율)
과발현 유전자
NM_000499	Cytochrome P450, family 1, subfamily A, polypeptide 1	CYP1A1	88.34	863.07
BX649164	serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1	SERPINE1	29.05	38.54
NM_004881	Tumor protein p53 inducible protein 3	TP53I3	16.67	26.57
BM913048	TIMP metallopeptidase inhibitor 1	TIMP1	14.52	26.48
NM_006426	Dihydropyrimidinase-like 4	DPYSL4	13.51	101.13
NM_133493	CD109 antigen(Gov platelet alloantigens)	CD109	12.97	45.46
AB033073	Sulfatase 2	SULF2	12.78	13.78
NM_021603	FXYD domain containing ion transport regulator 2	FXYD2	12.63	29.86
BC035124	MSFL2541	UNQ2541	11.28	13.61
Y11307	Cysteine-rich, angiogenic inducer, 61	CYR61	8.79	12.85
AK095363	Aquaporin 3	AQP3	8.26	46.53
AK097009	phospholipid transfer protein	PLTP	6.84	46.74
NM_004864	Growth differentiation factor 15	GDF15	6.65	38.76
BU587578	Regulator of G-protein signalling 10	RGS10	6.15	13.03
BQ683841	S100 calcium binding protein A11(calgizzarin)	S100A11	6.06	8.38
NM_001013632	polo-like kinase 3 (Drosophila)	PLK3	5.34	9.23
NM_032872	Synaptotagmin-like 1	SYTL1	4.93	10.43
BC042390	Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)	VTI1B	4.49	8.21
NM_000596	Insulin-like growth factor binding protein 1	IGFBP1	4.43	5.07
NM_005319	Histone 1, H1c	HIST1H1C	4.26	3.38
AK094474	Ras homolog gene family, member C	RHOC	4.23	3.41
NM_001769	CD9 antigen(p24)	CD9	4.15	1.71
NM_001553	Insulin-like growth factor binding protein 7	IGFBP7	3.47	11.02
NM_003897	Immediate early response 3	IER3	3.32	6.84
NM_003516	Histone 2, H2aa	HIST2H2AA	3.05	3.47
저발현 유전자
AK074377	Chromosome 19 open reading frame 31	UHRF1	0.16	0.19
BX640965	Solute carrier family 22(extraneuronal monoamine transporter), member 3	SLC22A3	0.26	0.23
NM_018492	PDZ binding kinase	PBK	0.28	0.21
CR600021	High-mobility group box 2	HMGB2	0.29	0.23
NM_006101	Kinetochore associated 2	KNTC2	0.30	0.26
NM_003318	TTK protein kinase	TTK	0.30	0.47
U65410	MAD2 mitotic arrest deficient-like 1(yeast)	MAD2L1	0.34	0.34
NM_001067	Topoisomerase(DNA) II alpha 170kDa	TOP2A	0.45	0.14
AB091343	Centrosomal protein 55kDa	C10orf3	0.45	0.63
BC022255	Spindle pole body component 25 homolog(S. cerevisiae)	Spc25	0.54	0.25

그 결과, 표 5에서 나타난 바와 같이 25종의 과발현 유전자들 및 10종의 저발현 유전자의 유전자 발현 양상은 크라이센에 의한 유전자 발현을 조사한 올리고 마이크로어레이 결과와 매우 유사하게 나타남을 확인하였다.

도 1은 크라이센(chrysene)의 인간 간암 세포주에서의 세포 독성을 조사한 그래프이다.

도 2는 마이크로어레이 칩을 이용한 크라이센을 처리한 인간 간암 세포주의 유전자 발현 양상을 분석한 결과를 나타내는 그림이다.

<110> Korea Institute of Science and Technology <120> Biomarker for identification of exoposure to chrysene and the method of identification using thereof <130> 8P-05-09 <160> 70 <170> KopatentIn 1.71 <210> 1 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> NM_000499 sense primer <400> 1 caccatcccc cacagcac 18 <210> 2 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> NM_000499 antisense primer <400> 2 acaaagacac aacgcccctt 20 <210> 3 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> BX649164 sense primer <400> 3 cagaccaaga gcctctccac 20 <210> 4 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> BX649164 antisense primer <400> 4 atcacttggc ccatgaaaag 20 <210> 5 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> NM_004881 sense primer <400> 5 agggtgaagt cctcctgaag gt 22 <210> 6 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> NM_004881 antisense primer <400> 6 gtgggtcata ctggccttgt ct 22 <210> 7 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> BM913048 sense primer <400> 7 gatacttcca caggtcccac aac 23 <210> 8 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> BM913048 antisense primer <400> 8 gcaagagtcc atcctgcagt t 21 <210> 9 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> NM_006426 sense primer <400> 9 tgggaagatg gacgagaatg agttcg 26 <210> 10 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_006426 antisense primer <400> 10 actccactcc ctcgaagatg ttgt 24 <210> 11 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_133493 sense primer <400> 11 gccaagattt accacgtttg ccca 24 <210> 12 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_133493 antisense primer <400> 12 tgaaggacca gaactgagcc acat 24 <210> 13 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AB03307 sense primer <400> 13 tgcggatatg gacgggaaat ccat 24 <210> 14 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AB03307 antisense primer <400> 14 tctcttgtgt agcagcttgc ctct 24 <210> 15 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_021603 sense primer <400> 15 ggcaataaga agcgcaggca aatc 24 <210> 16 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_021603 antisense primer <400> 16 aaggtctaaa gcccagggaa gaag 24 <210> 17 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> BC035124 sense primer <400> 17 ttcgccgtcc tttacatcta c 21 <210> 18 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> BC035124 antisense primer <400> 18 agagcctggg gactcacat 19 <210> 19 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Y11307 sense primer <400> 19 attgtagaaa ggaagccttg ctcat 25 <210> 20 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Y11307 antisense primer <400> 20 tccaatcgtg gctgcattag 20 <210> 21 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AK095363 sense primer <400> 21 ttcacgatcc accctttcag gcta 24 <210> 22 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AK095363 antisense primer <400> 22 acacatacct gctgcccatt ctct 24 <210> 23 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AK097009 sense primer <400> 23 tgccacagag aagacgggat ttga 24 <210> 24 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AK097009 antisense primer <400> 24 aggtggtgga cggactgtaa ttga 24 <210> 25 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> NM_004864 sense primer <400> 25 cctgagacac ccgattcct 19 <210> 26 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> NM_004864 antisense primer <400> 26 acagttccat cagaccagcc 20 <210> 27 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> BU587578 sense primer <400> 27 ccgtgccggg tttatcattg cttt 24 <210> 28 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> BU587578 antisense primer <400> 28 tcgacgtgtc cagtgttgaa ggaa 24 <210> 29 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> BQ683841 sense primer <400> 29 agtccctgat tgctgtcttc caga 24 <210> 30 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> BQ683841 antisense primer <400> 30 accagggtcc ttctggttct ttgt 24 <210> 31 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> NM_001013632 sense primer <400> 31 gactactcca ataagttcgg ctttg 25 <210> 32 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> NM_001013632 antisense primer <400> 32 catatgtgtg ccatcgttga aga 23 <210> 33 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_032872 sense primer <400> 33 ggcggtgaag aaacggaatc tgaa 24 <210> 34 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_032872 antisense primer <400> 34 gaaagatgtt gcgacccagg cttt 24 <210> 35 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> BC042390 sense primer <400> 35 gggggactaa cctatcgaga a 21 <210> 36 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> BC042390 antisense primer <400> 36 gatccagtgc tgatagcaac c 21 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_000596 sense primer <400> 37 atcattccat cctttgggac gcca 24 <210> 38 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_000596 antisense primer <400> 38 tgtctcctgt gccttggcta aact 24 <210> 39 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> NM_005319 sense primer <400> 39 accaaaccta agaagccagt tg 22 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> NM_005319 antisense primer <400> 40 tagcgctctt cttcggagtt 20 <210> 41 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> AK094474 sense primer <400> 41 acctgcctcc tcatcgtctt c 21 <210> 42 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> AK094474 antisense primer <400> 42 cacctgcttg ccgtccac 18 <210> 43 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_001769 sense primer <400> 43 gcaccaagtg catcaaatac ctgc 24 <210> 44 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_001769 antisense primer <400> 44 agccatagtc caatggcaag gaca 24 <210> 45 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_001553 sense primer <400> 45 acttgagctg tgaggtcatc ggaa 24 <210> 46 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_001553 antisense primer <400> 46 ataccagcac ccagccagtt actt 24 <210> 47 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003897 sense primer <400> 47 agccctttaa tctgacttcg gagc 24 <210> 48 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003897 antisense primer <400> 48 caggtacgcc tggtgtttct ttgt 24 <210> 49 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003516 sense primer <400> 49 gaactgaaca agctgctggg caaa 24 <210> 50 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003516 antisense primer <400> 50 tctccgtctt cttagggagc agta 24 <210> 51 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> AK074377 sense primer <400> 51 ctggtacgac gcggagat 18 <210> 52 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> AK074377 antisense primer <400> 52 cgacagtcgt tcagagaatc a 21 <210> 53 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> BX640965 sense primer <400> 53 gccctgttcc agcaataaga 20 <210> 54 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> BX640965 antisense primer <400> 54 gagagccaaa aatgtcccaa 20 <210> 55 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_018492 sense primer <400> 55 tctggactga gagtggcttt caca 24 <210> 56 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_018492 antisense primer <400> 56 agccaagctt ctgcataaac ggag 24 <210> 57 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> CR600021 sense primer <400> 57 cttggcacga tatgcagcaa 20 <210> 58 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> CR600021 antisense primer <400> 58 cagccaaaga taaacaacca tatga 25 <210> 59 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> NM_006101 sense primer <400> 59 tgctacacat gttgggtctg ta 22 <210> 60 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> NM_006101 antisense primer <400> 60 ccgagagatc ttctgacatg c 21 <210> 61 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003318 sense primer <400> 61 tcatgcccat ttggaagagt ccca 24 <210> 62 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> NM_003318 antisense primer <400> 62 aggcacaacc aaatctcggc attc 24 <210> 63 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> U65410 sense primer <400> 63 acttaaatat ctccctacct atactgagtc aa 32 <210> 64 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> U65410 antisense primer <400> 64 tagtaactgt agatggaaaa acttgtgcta 30 <210> 65 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> NM_001067 sense primer <400> 65 ctagttaatg ctgcggacaa ca 22 <210> 66 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> NM_001067 antisense primer <400> 66 catttcgacc acctgtcact t 21 <210> 67 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AB091343 sense primer <400> 67 gctgtgcatt tctcttggca gtga 24 <210> 68 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> AB091343 antisense primer <400> 68 tagacgctgc tcaccacatt ctgt 24 <210> 69 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> BC022255 sense primer <400> 69 gaatggttga gatgtttctg ga 22 <210> 70 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> BC022255 antisense primer <400> 70 gcaatcaatt ttaacaagtt atccttt 27

Claims

하기의 모든 유전자의 핵산서열의 전부 또는 그 서열 내에서 선택되는 연속적인 18개 내지 30개의 핵산 서열로 구성되는 상기 유전자의 단편인 올리고뉴클레오티드 또는 그의 상보가닥 올리고뉴클레오티드가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩:

유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
삭제
삭제
삭제
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;

2) 단계 1)의 실험군 및 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질로 표지하는 단계;

3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 제 1항의 DNA 마이크로어레이칩과 혼성화 시키는 단계;

4) 단계 3)의 반응한 DNA 마이크로어레이칩을 분석하는 단계; 및

5) 단계 4)의 분석한 데이터에서 제 1항의 DNA 마이크로어레이 칩에 집적된 유전자의 발현 정도를 대조군과 비교하여 크라이센에 대한 노출 여부를 판정하는 단계를 포함하는 크라이센에 대한 노출 여부를 확인하는 방법.
제 5항에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하는 방법.
제 6항에 있어서, 상기 인간 간암 세포는 HepG2인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하는 방법.
제 5항에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택하여 사용하는 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하는 방법.
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;

2) 단계 1)의 RNA를 대상으로, 하기의 모든 유전자에 대하여 각각의 유전자에 상보적이고 각각의 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및

3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계를 포함하는 크라이센에 대한 노출 여부를 확인하는 방법:

유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
제 9항에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하는 방법.
제 10항에 있어서, 상기 인간 간암 세포는 HepG2인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하는 방법.
제 1항의 DNA 마이크로어레이 칩을 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
제 12항에 있어서, 인간 간 세포 또는 간암 세포를 추가적으로 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
하기의 모든 유전자에 대하여 각각의 유전자에 상보적이고 각각의 유전자를 증폭할 수 있는 프라이머를 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트:

유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
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