KR100968762B1 - 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 - Google Patents

나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 Download PDF

Info

Publication number
KR100968762B1
KR100968762B1 KR1020080015344A KR20080015344A KR100968762B1 KR 100968762 B1 KR100968762 B1 KR 100968762B1 KR 1020080015344 A KR1020080015344 A KR 1020080015344A KR 20080015344 A KR20080015344 A KR 20080015344A KR 100968762 B1 KR100968762 B1 KR 100968762B1
Authority
KR
South Korea
Prior art keywords
genebank
registration number
gene registration
protein
gene
Prior art date
Application number
KR1020080015344A
Other languages
English (en)
Other versions
KR20090090083A (ko
Inventor
류재천
김연정
전희경
Original Assignee
한국과학기술연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국과학기술연구원 filed Critical 한국과학기술연구원
Priority to KR1020080015344A priority Critical patent/KR100968762B1/ko
Publication of KR20090090083A publication Critical patent/KR20090090083A/ko
Application granted granted Critical
Publication of KR100968762B1 publication Critical patent/KR100968762B1/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)

Abstract

본 발명은 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것으로, 구체적으로 다환 방향족 탄화수소류 중의 하나인 나프탈렌(Naphthalene)에 의해 특이적으로 유전자 발현이 증가 또는 감소하는 바이오마커 및 이를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법에 관한 것이다. 본 발명의 바이오마커는 DNA 마이크로어레이 칩을 통하여 선별된 반응 유전자들을 바이오마커로 이용하여 환경 시료에서 나프탈렌의 오염을 모니터링 및 판정하는데 유용하게 사용될 수 있으며, 나프탈렌에 의해 유발되는 독성 작용 기작을 규명하는 도구로 이용될 수 있다.
나프탈렌(Naphthalene), 다환 방향족 탄화수소, 바이오마커, 마이크로 어레이

Description

나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법{Biomarker for identification of exposure to naphthalene and the method of identification using thereof}
본 발명은 나프탈렌(naphthalene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것으로, 더욱 상세하게는 나프탈렌에 의해 유전자 발현이 증가 또는 감소하는 바이오마커 및 이를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법에 관한 것이다.
나프탈렌(Naphthalene)은 2개의 인접한 벤젠 고리로 구성된 다환 방향족 탄화수소류로서 물에는 거의 녹지 않으며, 휘발성이 강해서 대기압에서 기체 상태로 존재한다. 주로 프탈레이트 가소제, 수지 및 의약품 생산의 중간체로서 존재하며, 독특한 향을 가지고 있어 곤충기피제나 방취제로 사용된다. 또한, 가솔린과 디젤연료 중에 존재하며 자동차를 포함한 광범위한 발생원으로 인해 나프탈렌 농도는 공간에 따라 변동이 크고 일일 및 계절에 따른 변동 폭도 큰 것으로 알려져 있다. 나프탈렌의 환경 중 이동은 휘발성이 강해서 토양이나 지표수 중에서 대기로 쉽게 배출되어지며 대기 중 반감기는 1일 미만으로 보고되고 있다. 또한, 나프탈렌의 광산화물인 나프토퀴논(naphthoquinone) 및 니트로-나프탈렌(nitro-naphthalene)은 나프탈렌 자체보다 독성이 강한 것으로 알려져 있다.
국내의 상수원수에서 검출되는 미량유해물질조사에서 나프탈렌이 0 ~ 4.6 ㎍/ℓ의 농도범위로 검출되었으며(환경부 자료실, 1996), 도시산업지역의 지하수 오염특성조사연구에서도 약 0.2 ㎍/ℓ의 농도로 검출되었다(이평구 등, 도시산업지역 지하수 오염특성 및 예방 기법연구, 2003). 작업장 중에서도 아스팔트 흄에서의 다환방향족탄화수소류의 성분별 분석연구에서는 4.7 mg/m2의 농도로 나타났다(최재욱 등, 건설업 근로자의 유해 작업 환경 노출 실태에 관한 연구, 2000). 국외의 경우, 미국의 자동차 배기가스로 인한 나프탈렌의 대기농도 조사에서 샌프란시스코의 칼데콧(Caldecott) 터널과 로스엔젤로스 밴 나이스(Van Nuys) 터널에서 수집한 시료에서 각각 104.3 와 1,709 ㎍/m2의 농도로 검출되었다(Zielinska & Fung, Sci Total Environ 146/147:281-8, 1994; Fraser et al., Environ Sci Technol 32:2051-2060, 1998).
동물실험 결과, 나프탈렌의 반복, 및 단기 노출은 일차적으로 간독성 및 신경독성을 유발하는 것으로 보고되어지고 있으나, DNA 손상, 유전자 돌연변이, 염색체구조이상 및 염색체 수적 이상, 차세대 유전 독성 가능성을 유발하지 않는 것으로 보아 인체에서 유전 독성을 보일 가능성은 희박한 것으로 사료된다(국립독성과 학원, 독성물질국가관리사업, 2007).
또한, 나프탈렌은 세계보건기구(WHO) 산하의 국제암연구기관(IARC)에서 '인체 발암 가능성 물질'인 2B등급으로 분류하고 있으며(IARC, IARC Monogr Eval Carcinog Risks Hum 82: 367-435, 2002), 미국 환경부의 발암성 분류 등급에서는 ‘잠재적인 인체 발암물질’로 발암성 C등급으로 구분하고 있다(IRIS, U.S. Environmental Protection Agency Washington, DC: Integrated Risk Information System. http://www.epa.gov/iris/. June 6, 2003).
다환방향족 탄화수소류의 발암성 정도와 유전자 발현 변화에 대한 연구는 일부 보고되고 있지만, 대표적인 다환방향족 탄화수로류로 알려진 벤조에이파이렌(Benzo[a]pyrene)에 대한 연구에 거의 국한되어 있다. 이처럼 나프탈렌의 인간에 대한 발암 가능성에도 불구하고 인체에서의 위해도 평가 데이터가 충분하지 않고, 노출에 대한 검색 방법 역시 GC-MS(Gas Chromatography-Mass Spectrometer) 또는 HPLC(High Performance Liquid Chromatography) 등의 고전적인 방법에 국한되어 있다. GC-MS 또는 HPLC 방법 등을 이용하면 정량은 가능하나 분석을 위한 적정 조건을 설정하여야 하며 고가의 장비 등이 필요하다. 그러므로 보다 빠르고 간편한 스크리닝(screening) 방법, 예를 들면 프라이머(primer)를 이용하는 실시간(real-time) PCR(Real-time reverse transcript polymerase chain reaction) 또는 DNA 마이크로어레이 칩 등으로 신속한 위해성 평가를 통해 인체에서의 독성작용을 탐색할 수 있는 분자적 지표를 발굴하고 활용하여 나프탈렌의 노출에 대한 적절한 대책 및 관리를 수행하는 것이 중요한 과제라 하겠다.
포유류 6종, 미생물 292종 등 여러 종의 게놈(genome) 염기서열 프로젝트가 완성되어 NCBI(National Center for Biotechnology Information)에 보고되었다. 이렇게 얻어진 막대한 양의 데이터를 기본으로 유전자의 기능을 연구하기 위하여 게놈-와이드 익스프레션(genome-wide expression) 연구가 이루어지고 있다. 한번의 실험으로 수천 개의 유전자의 발현을 분석하기 위하여 DNA 마이크로어레이(microarray) 분석을 수행한다(Schena, M., et al., Proc . Natl . Acad . Sci . USA 93:10614-10619, 1996).
마이크로어레이는 cDNA(complementary DNA)나 20 ~ 25 염기쌍(base pair) 길이의 올리고뉴클레오티드(oligonucleotide)들의 세트를 유리에 집적화한 것이다. cDNA 마이크로어레이는 학교 내의 연구실 또는 애질런트(Agilent), 지노믹 솔루션(Genomic Solutions) 등의 회사에서 칩 위에 cDNA 수집물을 기계적으로 고정화 하거나 잉크젯(ink jetting) 방법을 이용하여 생산하고 있다(Sellheyer K. et. al., J. Am . Acad . Dermatol. 51:681-692, 2004). 올리고뉴클레오티드 마이크로어레이는 애피매트릭스(Affymetrix)사에서 사진 식각 공정(photolithography)을 이용하여 칩 위에서 직접 합성하는 방법에 의해 만들어지고 있으며, 애질런트(Agillent)사 등에는 합성된 올리고뉴클레오티드를 고정화하는 방법으로 생산하고 있다(Sellheyer, K. et. al., J. Am . Acad . Dermatol. 51:681-692, 2004).
유전자의 발현 분석을 위해서는 조직 등 시료에서 RNA를 얻어 DNA 마이크로어레이에 있는 올리고뉴클레오티드와 교잡반응을 수행한다. 얻어진 RNA는 형광이나 동위원소로 표지화하며 cDNA로 전환시킨다. 올리고 마이크로어레이는 주로 두개의 다른 형광(예: Cye3 및 Cye5)으로 대조군과 실험군을 각각 표지화하여 같은 칩 상에서 동시에 교잡 반응을 수행한 후 광학적으로 이미지를 스캔하여 형광의 세기를 얻고 그 결과를 분석한다. 두 개의 형광 세기의 비율에 따라 유전자의 발현 여부를 결정한다(Somasundaram, K. et al., Genomics Proteomics I:1-10, 2002).
최근 DNA 마이크로어레이 기술을 이용한 첨단 기법인 독성 유전체학(Toxicogenomics) 연구 등과 접목하여 대량(high throughput)으로 의약품 및 신의약 후보물질은 물론 대표적인 환경오염물질을 비롯하여 모든 화학물질에 의한 특정 조직이나 세포주에서 발현되는 유전자들의 발현 패턴의 분석, 양적 분석이 가능해졌다. 이에 따라 특정 세포 내에서 특정 유전자의 발현 빈도를 분석함으로써 약물의 부작용 및 환경오염물질의 유해작용과 관련된 유전자의 발굴이 가능하며, 이를 통하여 환경오염물질의 유해작용과 약물의 작용 및 부작용에 따른 분자적 메커니즘을 이해하게 될 것이며 나아가 독성 및 부작용을 유발하는 물질의 검색 및 이 가능하게 될 것이다.
이에 본 발명자들은 인간 유전자 4만 4천 개가 집적된 올리고마이크로어레이를 이용하여 나프탈렌의 유전자 발현 프로파일을 인간 간암 세포인 HepG2 세포주에서 관찰 및 분석함으로써 나프탈렌에 의해 과발현 또는 저발현 되는 유전자를 발굴 하고, 실시간(real-time) RT-PCR 방법에 의해 상기 유전자들의 발현 양상을 확인함으로써 나프탈렌을 검출할 수 있는 바이오마커 및 이를 이용한 노출 여부를 확인하는 방법을 확립하여 본 발명을 완성하였다.
본 발명의 목적은 나프탈렌(Naphthalene)의 노출에 의해 과발현 또는 저발현되는 바이오마커 및 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 나프탈렌(naphthalene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 나프탈렌에 대한 노출 여부 확인용 바이오마커를 제공한다.
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 이의 상보가닥 분자가 집적된 나프탈렌에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.
또한, 본 발명은 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다.
아울러, 본 발명은 나프탈렌에 대한 노출 여부 확인용 검색 키트를 제공한다.
본 발명의 나프탈렌(naphthalene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법은 DNA 마이크로어레이 칩을 통하여 선별된 반응 유전자들을 바이오마커로 이용하여 나프탈렌의 모니터링 및 위해성을 판정하는데 유용하며, 나프탈렌에 의해 야기되는 독성 작용 기작을 규명하는 도구로 이용할 수 있다.
이하, 본 발명을 상세히 설명한다.
본 발명은 나프탈렌(naphthalene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 나프탈렌에 대한 노출 여부 확인용 바이오마커를 제공한다.
상기 바이오마커는 2배 이상 발현이 증가 또는 감소한 유전자로써, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction) 등의 관련 유전자로 구성되어 있다.
본 발명은 하기와 같이 구성된 군에서 선택되어지는 것을 특징으로 하는 바 이오마커를 제공한다:
유전자 등록번호(Genebank) BC063507(HSPA1B, Heat shock 70kDa protein 1B), 유전자 등록번호(Genebank) NM_016639(TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), 유전자 등록번호(Genebank) NM_033027(AXUD1, AXIN1 up-regulated 1), 유전자 등록번호(Genebank) AF332558(BBC3, BCL2 binding component 3), 유전자 등록번호(Genebank) NM_138639(BCL2L12, BCL2-like 12(proline rich)), 유전자 등록번호(Genebank) AK124526(BCAR1, Breast cancer anti-estrogen resistance 1), 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016222(DDX41, DEAD(Asp-Glu-Ala-Asp) box polypeptide 41), 유전자 등록번호(Genebank) NM_022105(DATF1, Death inducer-obliterator 1), 유전자 등록번호(Genebank) AK127033(DNM2, Dynamin 2), 유전자 등록번호(Genebank) NM_152461(ERN1, Endoplasmic reticulum to nucleus signalling 1), 유전자 등록번호(Genebank) NM_003806(HRK, Harakiri, BCL2 interacting protein(contains only BH3 domain)), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) NM_003639(IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), 유전자 등록번호(Genebank) BX640923(MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein(mouse)), 유전자 등록번호(Genebank) NM_002648(PIM1, Pim-1 oncogene), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_004309(ARHGDIA, Rho GDP dissociation inhibitor(GDI) alpha), 유전자 등록번호(Genebank) BC041022(SCAND1, SCAN domain containing 1), 유전자 등록번호(Genebank) NM_006282(STK4, Serine/threonine kinase 4), 유전자 등록번호(Genebank) AB005666(SIPA1, Signal-induced proliferation-associated gene 1), 유전자 등록번호(Genebank) NM_207111(TRIAD3, TRIAD3 protein), 유전자 등록번호(Genebank) AY247738(TRIB3, Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AF026071(TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), 유전자 등록번호(Genebank) AB209485(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) CR606241(ACTG1, Actin, gamma 1), 유전자 등록번호(Genebank) NM_012127(CIZ1, CDKN1A interacting zinc finger protein 1), 유전자 등록번호(Genebank) AK057576(CHFR, Checkpoint with forkhead and ring finger domains), 유전자 등록번호(Genebank) NM_005255(GAK, Cyclin G associated kinase), 유전자 등록번호(Genebank) NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) AK094316(MAD2L2, MAD2 mitotic arrest deficient-like 2(yeast)), 유전자 등록번호(Genebank) NM_002595(PCTK2, PCTAIRE protein kinase 2), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), 유전자 등록번호(Genebank) X06374(PDGFA, Platelet-derived growth factor alpha polypeptide), 유전자 등록번호(Genebank) NM_001722(POLR3D, Polymerase(RNA) III(DNA directed) polypeptide D, 44kDa), 유전자 등록번호(Genebank) NM_002808(PSMD2, Proteasome(prosome, macropain) 26S subunit, non-ATPase, 2), 유전자 등록번호(Genebank) BC038504(SNF1LK, SNF1-like kinase), 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) NM_000548(TSC2, Tuberous sclerosis 2), 유전자 등록번호(Genebank) AK223618(ZBTB17, Zinc finger and BTB domain containing 17), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) AY258066(OKL38, Pregnancy-induced growth inhibitor), 유전자 등록번호(Genebank) NM_001012661(SLC3A2, Solute carrier family 3(activators of dibasic and neutral amino acid transport), member 2), 유전자 등록번호(Genebank) NM_014598(SOCS7, Suppressor of cytokine signaling 7), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) NM_015366(FLJ20185, Rho GTPase activating protein 8), 유전자 등록번호(Genebank) AB209322(SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3B), 유전자 등록번호(Genebank) AB209463(CSNK1D, Casein kinase 1, delta), 유전자 등록번호(Genebank) NM_005228(EGFR, Epidermal growth factor receptor(erythroblastic leukemia viral(v-erb-b) oncogene homolog, avian)), 유전자 등록번호(Genebank) BC089041(GNA11, Guanine nucleotide binding protein(G protein), alpha 11(Gq class)), 유전자 등록번호(Genebank) NM_002224(ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), 유전자 등록번호(Genebank) NM_012463(ATP6V0A2, ATPase, H+transport -ing, lysosomal V0 subunit a isoform 2), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) NM_000574(DAF, Decay accelerating factor for complement(CD55, Cromer blood group system)), 유전자 등록번호(Genebank) NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), 유전자 등록번호(Genebank) BG171626(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) BM905227(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) NM_001015053(HDAC5, Histone deacetylase 5), 유전자 등록번호(Genebank) NM_003641(IFITM1, Interferon induced transmembrane protein 1(9-27)), 유전자 등록번호(Genebank) AF200496(IL1F7, Interleukin 1 family, member 7(zeta)), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) NM_000565(IL6R, Interleukin 6 receptor), 유전자 등록번호(Genebank) NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)), 유전자 등록번호(Genebank) NM_001300(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), 유전자 등록번호(Genebank) NM_017670(OTUB1, OTU domain, ubiquitin aldehyde binding 1), 유전자 등록번호(Genebank) NM_139276(STAT3, Signal transducer and activator of transcription 3(acute-phase response factor)), 유전자 등록번호(Genebank) NM_003037(SLAMF1, Signaling lymphocytic activation molecule family member 1), 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) NM_001353(AKR1C1, Aldo-keto reductase family 1, member C1(dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase)), 유전자 등록번호(Genebank) NM_001769(CD9, CD9 antigen(p24)), 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK095781(CIRBP, Cold inducible RNA binding protein), 유전자 등록번호(Genebank) X14789(CRYAA, Crystallin, alpha A), 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_080927(DCBLD2, Discoidin, CUB and LCCL domain containing 2), 유전자 등록번호(Genebank) AY253982(GPR54, G protein-coupled receptor 54), 유전자 등록번호(Genebank) AF073799(GALR3, Galanin receptor 3), 유전자 등록번호(Genebank) BI767815(GP9, Glycoprotein IX(platelet)), 유전자 등록번호(Genebank) NM_007353(GNA12, Guanine nucleotide binding protein(G protein) alpha 12), 유전자 등록번호(Genebank) CR623806(HSPA6, Heat shock 70kDa protein 6(HSP70B')), 유전자 등 록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK000252(FLJ20245, Hypothetical protein FLJ20245), 유전자 등록번호(Genebank) AK057577(IRF3, Interferon regulatory factor 3), 유전자 등록번호(Genebank) L76191(IRAK1, Interleukin-1 receptor-associated kinase 1), 유전자 등록번호(Genebank) BC053882(MT1X, Metallothionein 1X), 유전자 등록번호(Genebank) AK124709(NDRG1, N-myc downstream regulated gene 1), 유전자 등록번호(Genebank) NM_002658(PLAU, Plasminogen activator, urokinase), 유전자 등록번호(Genebank) U02389(PRSS15, Protease, serine, 15), 유전자 등록번호(Genebank) NM_005053(RAD23A, RAD23 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) CD357517(Unknown, Similar to Interferon-induced transmembrane protein 3(Interferon-inducible protein 1-8U)), 유전자 등록번호(Genebank) NM_032038(SPINL, Spinster), 유전자 등록번호(Genebank) H18681(C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BX648190(WDR1, WD repeat domain 1), 유전자 등록번호(Genebank) AK074035(XAB2, XPA binding protein 2), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_017572(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_030662(MAP2K2, Mitogen-activated protein kinase kinase 2), 유전자 등록번호(Genebank) AB208849(SHC1, SHC(Src homology 2 domain containing) transforming protein 1), 유전자 등록번호(Genebank) NM_138473(SP1, Sp1 transcription factor), 유전자 등록번호(Genebank) X02812(TGFB1, Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_002880(RAF1, V-raf-1 murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_152221(CSNK1E, Casein kinase 1, epsilon), 유전자 등록번호(Genebank) AB209210(DVL1, Dishevelled, dsh homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) AF077820(LRP5, Low density lipoprotein receptor-related protein 5), 유전자 등록번호(Genebank) NM_033119(NKD1, Naked cuticle homolog 1(Drosophila)), 유전자 등록번호(Genebank) AK090488(PPP2R1A, Protein phosphatase 2(formerly 2A), regulatory subunit A(PR 65), alpha isoform), 유전자 등록번호(Genebank) AL834166(TCF7, Transcription factor 7(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003255(TIMP2, TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_014595(NT5C, 5', 3'-nucleotidase, cytosolic), 유전자 등록번호(Genebank) AY461712(ATP13A2, ATPase type 13A2), 유전자 등록번호(Genebank) NM_018590(GALNACT-2, Chondroitin sulfate GalNAcT-2), 유전자 등록번호(Genebank) NM_080757(C20orf127, Chromosome 20 open reading frame 127), 유전자 등록번호(Genebank) X16866(CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), 유전자 등록번호(Genebank) NM_000782(CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), 유전자 등록번호(Genebank) NM_000786(CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_017556(FBLP-1, Filamin binding LIM protein 1), 유전자 등록번호(Genebank) AK093560(INPP1, Inositol polyphosphate-1-phosphatase), 유전자 등록번호(Genebank) NM_005578(LPP, LIM domain containing preferred translocation partner in lipoma), 유전자 등록번호(Genebank) AK222601(MMP10, Matrix metallopeptidase 10(stromelysin 2)), 유전자 등록번호(Genebank) NM_005947(MT1B, Metallothionein 1B(functional)), 유전자 등록번호(Genebank) BC048334(MT1G, Metallothionein 1G), 유전자 등록번호(Genebank) BI488702(MT1K, Metallothionein 1M), 유전자 등록번호(Genebank) NM_182924(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK127759(NDUFS7, NADH dehydrogenase(ubiquinone) Fe-S protein 7, 20kDa(NADH-coenzyme Q reductase)), 유전자 등록번호(Genebank) NM_203353(PDLIM7, PDZ and LIM domain 7(enigma)), 유전자 등록번호(Genebank) NM_002627(PFKP, Phosphofructokinase, platelet), 유전자 등록번호(Genebank) AA862994(S100A3, S100 calcium binding protein A3), 유전자 등록번호(Genebank) NM_003461(ZYX, Zyxin), 유전자 등록번호(Genebank) NM_019112(ABCA7, ATP-binding cassette, sub-family A(ABC1), member 7), 유전자 등록번호(Genebank) AB209054(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), 유전자 등록번호(Genebank) NM_020038(ABCC3, ATP-binding cassette, sub-family C(CFTR/MRP), member 3), 유전자 등록번호(Genebank) BC025358(ABCD1, ATP-binding cassette, sub-family D(ALD), member 1), 유전자 등록번호(Genebank) NM_003992(CLK3, CDC-like kinase 3), 유전자 등록번호(Genebank) AK128154(C9orf86, Chromosome 9 open reading frame 86), 유전자 등록번호(Genebank) BC006404(SKD3, ClpB caseinolytic peptidase B homolog(E. coli)), 유전자 등록번호(Genebank) BC067254(COASY, Coenzyme A synthase), 유전자 등록번호(Genebank) NM_004398(DDX10, DEAD(Asp-Glu-Ala-Asp) box polypeptide 10), 유전자 등록번호(Genebank) BC038417(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_138614(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_032656(DHX37, DEAH(Asp-Glu-Ala-His) box polypeptide 37), 유전자 등록번호(Genebank) NM_020812(DOCK6, Dedicator of cytokinesis 6), 유전자 등록번호(Genebank) NM_004431(EPHA2, EPH receptor A2), 유전자 등록번호(Genebank) NM_001961(EEF2, Eukaryotic translation elongation factor 2), 유전자 등록번호(Genebank) NM_003751(EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), 유전자 등록번호(Genebank) AF114818(SIAHBP1, Fuse-binding protein-interacting repressor), 유전자 등록번호(Genebank) NM_019096(GTPBP2, GTP binding protein 2), 유전자 등록번호(Genebank) NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), 유전자 등록번호(Genebank) AK128226(HK1, Hexokinase 1), 유전자 등록번호(Genebank) BC069201(FLJ22761, Hexokinase domain containing 1), 유전자 등록번호(Genebank) NM_006546(IMP-1, IGF-II mRNA-binding protein 1), 유전자 등록번호(Genebank) NM_015155(KIAA0217, La ribonucleoprotein domain family, member 5), 유전자 등록번호(Genebank) NM_018357(FLJ11196, La ribonucleoprotein domain family, member 6), 유전자 등록번호(Genebank) AK127089(MTHFD1L, Methylenetetrahydrofolate dehydrogenase(NADP+ dependent) 1-like), 유전자 등록번호(Genebank) XM_038150(MAST3, Microtubule associated serine/threonine kinase 3), 유전자 등록번호(Genebank) AB058686(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) BC027875(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) K122664(NRBP, Nuclear receptor binding protein), 유전자 등록번호(Genebank) NM_001001852(PIM3, Pim-3 oncogene), 유전자 등록번호(Genebank) BC094766(PKN1, Protein kinase N1), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_019034(RHOF, Ras homolog gene family, member F(in filopodia)), 유전자 등록번호(Genebank) NM_016084(RASD1, RAS, dexamethasone-induced 1), 유전자 등록번호(Genebank) AY369207(RBPMS2, RNA binding protein with multiple splicing 2), 유전자 등록번호(Genebank) BC069233(SCYL1, SCY1-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AB209553(STK11, Serine/threonine kinase 11), 유전자 등록번호(Genebank) AK124047(C20orf119, Similar to embryonic poly(A) binding protein), 유전자 등록번호(Genebank) XM_496374(LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), 유전자 등록번호(Genebank) NM_005094(SLC27A4, Solute carrier family 27(fatty acid transporter), member 4) 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) NM_025195(TRIB1, Tribbles homolog 1(Drosophila)), 유전자 등록번호(Genebank) BC009900(UBE1, Ubiquitin-activating enzyme E1(A1S9T and BN75 temperature sensitivity complementing)), 유전자 등록번호(Genebank) AF045458(ULK1, Unc-51-like kinase 1(C. elegans)), 유전자 등록번호(Genebank) X59303(VARS2, Valyl-tRNA synthetase), 유전자 등록번호(Genebank) AB209808(AP1M1, Adaptor-related protein complex 1, mu 1 subunit), 유전자 등록번호(Genebank) AB208804(AP3D1, Adaptor-related protein complex 3, delta 1 subunit), 유전자 등록번호(Genebank) BC000786(ARFGAP1, ADP- ribosylation factor GTPase activating protein 1), 유전자 등록번호(Genebank) AK125277(APG4B, ATG4 autophagy related 4 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_007097(CLTB, Clathrin, light polypeptide(Lcb)), 유전자 등록번호(Genebank) AK091056(COBRA1, Cofactor of BRCA1), 유전자 등록번호(Genebank) AF349676(COG3, Component of oligomeric golgi complex 3), 유전자 등록번호(Genebank) AB002368(XPO6, Exportin 6), 유전자 등록번호(Genebank) BX648781(GABARAPL1, GABA(A) receptor-associated protein like 1), 유전자 등록번호(Genebank) AK123405(GDI1, GDP dissociation inhibitor 1), 유전자 등록번호(Genebank) NM_004712(HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), 유전자 등록번호(Genebank) AK094897(IPO4, Importin 4), 유전자 등록번호(Genebank) L38951(KPNB1, Karyopherin(importin) beta 1), 유전자 등록번호(Genebank) NM_002268(KPNA4, Karyopherin alpha 4(importin alpha 3)), 유전자 등록번호(Genebank) AY014403(KIF13A, Kinesin family member 13A), 유전자 등록번호(Genebank) NM_002867(RAB3B, RAB3B, member RAS oncogene family), 유전자 등록번호(Genebank) AK025300(RANBP3, RAN binding protein 3), 유전자 등록번호(Genebank) AB014551(ARHGEF2, Rho/rac guanine nucleotide exchange factor(GEF) 2), 유전자 등록번호(Genebank) CD049342(RPL23, Ribosomal protein L23), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) NM_006809(TOMM34, Translocase of outer mitochondrial membrane 34), 유전자 등 록번호(Genebank) BC047528(TOMM40, Translocase of outer mitochondrial membrane 40 homolog(yeast)), 유전자 등록번호(Genebank) AK056701(VPS11, Vacuolar protein sorting 11(yeast)), 유전자 등록번호(Genebank) BC042390(VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) AK095154(AES, Amino-terminal enhancer of split), 유전자 등록번호(Genebank) BC060828(ARID3A, AT rich interactive domain 3A(BRIGHT- like)), 유전자 등록번호(Genebank) NM_003670(BHLHB2, Basic helix-loop-helix domain containing, class B, 2), 유전자 등록번호(Genebank) NM_006442(DRAP1, DR1-associated protein 1(negative cofactor 2 alpha)), 유전자 등록번호(Genebank) NM_006532(ELL, Elongation factor RNA polymerase II), 유전자 등록번호(Genebank) NM_001991(EZH1, Enhancer of zeste homolog 1(Drosophila)), 유전자 등록번호(Genebank) U18018(ETV4, Ets variant gene 4(E1A enhancer binding protein, E1AF)), 유전자 등록번호(Genebank) NM_002018(FLII, Flightless I homolog(Drosophila)), 유전자 등록번호(Genebank) NM_181430(FOXK2, Forkhead box K2), 유전자 등록번호(Genebank) NM_001012426(FOXP4, Forkhead box P4), 유전자 등록번호(Genebank) BC053850(FOXQ1, Forkhead box Q1), 유전자 등록번호(Genebank) AF176422(HEY1, Hairy/enhancer-of-split related with YRPW motif 1), 유전자 등록번호(Genebank) BC078664(HMGA1, High mobility group AT-hook 1), 유전자 등록번호(Genebank) XM_379934(KIAA1718, KIAA1718 protein), 유전자 등록번호(Genebank) BC069156(LBX1, Ladybird homeobox homolog 1(Drosophila)), 유전 자 등록번호(Genebank) NM_014520(MYBBP1A, MYB binding protein(P160) 1a), 유전자 등록번호(Genebank) NM_002518(NPAS2, Neuronal PAS domain protein 2), 유전자 등록번호(Genebank) NM_001001716(NFKBIB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta), 유전자 등록번호(Genebank) AF087856(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002653(PITX1, Paired-like homeodomain transcription factor 1), 유전자 등록번호(Genebank) NM_001003891(PCQAP, PC2(positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein), 유전자 등록번호(Genebank) NM_005035(POLRMT, Polymerase(RNA) mitochondrial(DNA directed)), 유전자 등록번호(Genebank) NM_012448(STAT5B, Signal transducer and activator of transcription 5B), 유전자 등록번호(Genebank) CR607342(RNPS1, Similar to splicing-related factor RNPS1), 유전자 등록번호(Genebank) NM_005986(SOX1, SRY(sex determining region Y)-box 1), 유전자 등록번호(Genebank) NM_003072(SMARCA4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), 유전자 등록번호(Genebank) NM_006951(TAF5, TAF5 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 100kDa), 유전자 등록번호(Genebank) NM_152380(TBX15, T-box 15), 유전자 등록번호(Genebank) NM_016569(TBX3, T-box 3(ulnar mammary syndrome)), 유전자 등록번호(Genebank) BC006396(TLX2, T-cell leukemia, homeobox 2), 유전자 등록번호(Genebank) AF106934(THRAP5, Thyroid hormone receptor associated protein 5), 유전자 등록번호(Genebank) AF108461(UBN1, Ubinuclein 1), 유전자 등록번호(Genebank) NM_002359(MAFG, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G(avian)), 유전자 등록번호(Genebank) AK092414(MAFK, V-maf musculoaponeurotic fibrosarcoma oncogene homolog K(avian)), 유전자 등록번호(Genebank) AK128553(ZZANK1, Mindbomb homolog 2(Drosophila)), 유전자 등록번호(Genebank) NM_001003694(BRPF1, Bromodomain and PHD finger containing, 1), 유전자 등록번호(Genebank) CR936799(FHL2, Four and a half LIM domains 2), 유전자 등록번호(Genebank) NM_139201(GIT2, G protein-coupled receptor kinase interactor 2), 유전자 등록번호(Genebank) AK125974(p66alpha, GATA zinc finger domain containing 2A), 유전자 등록번호(Genebank) CB050471(GLI4, GLI-Kruppel family member GLI4), 유전자 등록번호(Genebank) NM_006734(HIVEP2, Human immunodeficiency virus type I enhancer binding protein 2), 유전자 등록번호(Genebank) NM_031297(DKFZP761H1710, Hypothetical protein DKFZp761H1710), 유전자 등록번호(Genebank) NM_024671(FLJ23436, Hypothetical protein FLJ23436), 유전자 등록번호(Genebank) NM_173680(MGC33584, Hypothetical protein MGC33584), 유전자 등록번호(Genebank) NM_031918(KLF16, Kruppel-like factor 16), 유전자 등록번호(Genebank) BU163740(MKRN1, Makorin, ring finger protein, 1), 유전자 등록번호(Genebank) NM_005885(MARCH-V, Membrane-associated ring finger(C3HC4) 6), 유전자 등록번호(Genebank) AF242768(LOC51333, Mesenchymal stem cell protein DSC43), 유전자 등록번호(Genebank) NM_020774(MIB1, Mindbomb homolog 1(Drosophila)), 유전자 등록번호(Genebank) AJ007041(MLL4, Myeloid/lymphoid or mixed-lineage leukemia 4), 유전자 등록번호(Genebank) BF206103(ZNF286, Peroxisome proliferative activated receptor, alpha-like), 유전자 등록번호(Genebank) BC008834(PHF1, PHD finger protein 1), 유전자 등록번호(Genebank) D87076(PHF15, PHD finger protein 15), 유전자 등록번호(Genebank) NM_020122(KCMF1, Potassium channel modulatory factor 1), 유전자 등록번호(Genebank) NM_145214(TRIM11, Tripartite motif-containing 11), 유전자 등록번호(Genebank) NM_033452(TRIM47, Tripartite motif-containing 47), 유전자 등록번호(Genebank) AF281046(TRIM8, Tripartite motif-containing 8), 유전자 등록번호(Genebank) BC004256(ZNF259, Zinc finger protein 259), 유전자 등록번호(Genebank) CR597101(ZFP36, Zinc finger protein 36, C3H type, homolog(mouse)), 유전자 등록번호(Genebank) NM_198055(ZNF42, Zinc finger protein 42(myeloid-specific retinoic acid-responsive)), 유전자 등록번호(Genebank) BC071620(ZNF581, Zinc finger protein 581), 유전자 등록번호(Genebank) BM544755(ZNF593, Zinc finger protein 593), 유전자 등록번호(Genebank) AK024487(ZNF598, Zinc finger protein 598), 유전자 등록번호(Genebank) BC089449(ZEC, Zinc finger protein 628), 유전자 등록번호(Genebank) NM_153813(ZFPM1, Zinc finger protein, multitype 1), 유전자 등록번호(Genebank) BM451410(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BX648551(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BC006340(ZCCHC2, Zinc finger, CCHC domain containing 2), 유전자 등록번호(Genebank) BC053544(ZDHHC8, Zinc finger, DHHC-type containing 8), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BQ939577(AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)), 유전자 등록번호(Genebank) AB045292(TMEM8, Transmembrane protein 8(five membrane-spanning domains)), 유전자 등록번호(Genebank) NM_012088(PGLS, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) NM_184041(ALDOA, Aldolase A, fructose-bisphosphate), 유전자 등록번호(Genebank) NM_000402(G6PD, Glucose-6-phosphate dehydrogenase), 유전자 등록번호(Genebank) NM_006715(MAN2C1, Mannosidase, alpha, class 2C, member 1), 유전자 등록번호(Genebank) CR597860(C19orf27, Chromosome 19 open reading frame 27), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) BC042195(MT, Malonyl-CoA:acyl carrier protein transacylase, mitochondrial), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) AK057049(PTGES2, Prostaglandin E synthase 2), 유전자 등록번호(Genebank) AB046825(GBA2, Glucosidase, beta(bile acid) 2), 유전자 등록번호(Genebank) BC033110(HSD17B1, Hydroxysteroid(17-beta) dehydrogenase 1), 유전자 등록번호(Genebank) BC050553(NTE, Neuropathy target esterase), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) NM_005028(PIP5K2A, Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha), 유전자 등록번호(Genebank) BC007612(PSAP, Prosaposin(variant Gaucher disease and variant metachromatic leukodystrophy)), 유전자 등록번호(Genebank) BC087612(SBF1, SET binding factor 1), 유전자 등록번호(Genebank) BQ683841(S100A11, S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) CK000930(HIST1H2AI, Histone 1, H2ai), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) BC069193(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK223291(MMP3, Matrix metallopeptidase 3(stromelysin 1, progelatinase)), 유전자 등록번호(Genebank) NM_178819(DKFZp586M1819, 1-acylglycerol-3-phosphate O-acyltransferase 6(lysophosphatidic acid acyltransferase, zeta)), 유전자 등록번호(Genebank) NM_018694(ARL6IP4, ADP-ribosylation-like factor 6 interacting protein 4), 유전자 등록번호(Genebank) BC014895(MGC10204, Aldehyde dehydrogenase 16 family, member A1), 유전자 등록번호(Genebank) NM_032468(ASPH, Aspartate beta-hydroxylase), 유전자 등록번 호(Genebank) BC008751(CAPN1, Calpain 1,(mu/I) large subunit), 유전자 등록번호(Genebank) AK128552(CAPN10, Calpain 10), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) NM_001903(CTNNA1, Catenin(cadherin-associated protein), alpha 1, 102kDa), 유전자 등록번호(Genebank) BC067289(CTSL2, Cathepsin L2), 유전자 등록번호(Genebank) NM_015151(C21orf106, Chromosome 21 open reading frame 106), 유전자 등록번호(Genebank) NM_031434(C7orf21, Chromosome 7 open reading frame 21), 유전자 등록번호(Genebank) NM_001303(COX10, COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase(yeast)), 유전자 등록번호(Genebank) BP317375(COX6A2, Cytochrome c oxidase subunit VIa polypeptide 2), 유전자 등록번호(Genebank) NM_001355(DDT, D-dopachrome tautomerase), 유전자 등록번호(Genebank) NM_032482(DOT1L, DOT1-like, histone H3 methyltransferase(S. cerevisiae)), 유전자 등록번호(Genebank) NM_004419(DUSP5, Dual specificity phosphatase 5), 유전자 등록번호(Genebank) AB210013(EIF4G1, Eukaryotic translation initiation factor 4 gamma, 1), 유전자 등록번호(Genebank) NM_020158(EXOSC5, Exosome component 5), 유전자 등록번호(Genebank) NM_178225(FBXW5, F-box and WD-40 domain protein 5), 유전자 등록번호(Genebank) NM_058229(FBXO32, F-box protein 32), 유전자 등록번호(Genebank) AB209592(GMPPA, GDP-mannose pyrophosphorylase A), 유전자 등록번호(Genebank) AJ002231(GNPDA1, Glucosamine-6-phosphate deaminase 1), 유전자 등록번 호(Genebank) AK094940(GCLC, Glutamate-cysteine ligase, catalytic subunit), 유전자 등록번호(Genebank) NM_005318(H1F0, H1 histone family, member 0), 유전자 등록번호(Genebank) NM_004639(BAT3, HLA-B associated transcript 3), 유전자 등록번호(Genebank) NM_032717(MGC11324, Hypothetical protein MGC11324), 유전자 등록번호(Genebank) BX647357(IDS, Iduronate 2-sulfatase(Hunter syndrome)), 유전자 등록번호(Genebank) AY923172(KLK13, Kallikrein 13), 유전자 등록번호(Genebank) AK023137(MGAT4B, Mannosyl(alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B), 유전자 등록번호(Genebank) NM_024864(FLJ22578, Mitochondrial rRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_153006(NAGS, N-acetylglutamate synthase), 유전자 등록번호(Genebank) NM_020230(PPAN, Peter pan homolog(Drosophila)), 유전자 등록번호(Genebank) BC017045(PYGB, Phosphorylase, glycogen; brain), 유전자 등록번호(Genebank) NM_005401(PTPN14, Protein tyrosine phosphatase, non-receptor type 14), 유전자 등록번호(Genebank) AF290614(PTPN23, Protein tyrosine phosphatase, non-receptor type 23), 유전자 등록번호(Genebank) BX648253(PTPN3, Protein tyrosine phosphatase, non-receptor type 3), 유전자 등록번호(Genebank) NM_002840(PTPRF, Protein tyrosine phosphatase, receptor type, F), 유전자 등록번호(Genebank) D15049(PTPRH, Protein tyrosine phosphatase, receptor type, H), 유전자 등록번호(Genebank) AF348492(RBAF600, Retinoblastoma-associated factor 600), 유전자 등록번 호(Genebank) BM926478(RBP1, Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) AB209196(RNH, Ribonuclease/angiogenin inhibitor 1), 유전자 등록번호(Genebank) CR619918(RPL18A, Ribosomal protein L18a), 유전자 등록번호(Genebank) BM553074(RPS15A, Ribosomal protein S15a), 유전자 등록번호(Genebank) CD387408(RPS28, Ribosomal protein S28), 유전자 등록번호(Genebank) CR749837(RPS7, Ribosomal protein S7), 유전자 등록번호(Genebank) BM805682(EEF1D, Similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein), 유전자 등록번호(Genebank) XM_069734(LOC136143, Similar to ribosomal protein L18; 60S ribosomal protein L18), 유전자 등록번호(Genebank) BG186194(RPS24, Similar to ribosomal protein S24), 유전자 등록번호(Genebank) AB037719(SSH1, Slingshot homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005415(SLC20A1, Solute carrier family 20(phosphate transporter), member 1), 유전자 등록번호(Genebank) BF680536(SAT, Spermidine/spermine N1-acetyltransferase), 유전자 등록번호(Genebank) AK127286(SMOX, Spermine oxidase), 유전자 등록번호(Genebank) NM_005877(SF3A1, Splicing factor 3a, subunit 1, 120kDa), 유전자 등록번호(Genebank) AF082557(TNKS, Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase), 유전자 등록번호(Genebank) BC002856(TXNDC11, Thioredoxin domain containing 11) 유전자 등록번호(Genebank) NM_017722(FLJ20244, TRM1 tRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK023077(USP36, Ubiquitin specific peptidase 36), 유전자 등록번호(Genebank) NM_080605(B3GALT6, UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6), 유전자 등록번호(Genebank) AY358955(B3GNT3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3), 유전자 등록번호(Genebank) AK074143(UAP1L1, UDP-N-acteylglucosamine pyrophosphorylase 1-like 1), 유전자 등록번호(Genebank) C007348(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) BC047030(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) BU945318(MT2A, Hypothetical gene supported by X97260; BC070289), 유전자 등록번호(Genebank) BX537968(LOC51149, Hypothetical LOC51149), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) XM_371474(PLXNB2, Plexin B2), 유전자 등록번호(Genebank) BC050636(FLJ14249, HS1-binding protein 3), 유전자 등록번호(Genebank) NM_004699(FAM50A, Family with sequence similarity 50, member A), 유전자 등록번호(Genebank) AY368150 (CHR2SYT, Family with sequence similarity 62(C2 domain containing) member B), 유전자 등록번호(Genebank) AF130077(ALB, Albumin), 유전자 등록번호(Genebank) NM_021631(FKSG2, Apoptosis inhibitor), 유전자 등록번호(Genebank) AF143236(C17orf88, Apoptosis related protein), 유전자 등록번호(Genebank) NM_001621(AHR, Aryl hydrocarbon receptor), 유전자 등록번호(Genebank) AB209123(BIRC1, Baculoviral IAP repeat-containing 1), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) NM_001167(BIRC4, Baculoviral IAP repeat-containing 4), 유전자 등록번호(Genebank) AW872828(BIRC6, Baculoviral IAP repeat-containing 6(apollon)), 유전자 등록번호(Genebank) AU146963(BCL2, B-cell CLL/lymphoma 2), 유전자 등록번호(Genebank) NM_004331(BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like), 유전자 등록번호(Genebank) NM_001015049(BAG5, BCL2-associated athanogene 5), 유전자 등록번호(Genebank) NM_014739(BCLAF1, BCL2-associated transcription factor 1), 유전자 등록번호(Genebank) L33477(HSPD1, Cadherin 12, type 2(N-cadherin 2)), 유전자 등록번호(Genebank) NM_001904(CTNNB1, Catenin(cadherin-associated protein), beta 1, 88kDa), 유전자 등록번호(Genebank) NM_005894(CD5L, CD5 antigen-like(scavenger receptor cysteine rich family)), 유전자 등록번호(Genebank) AK124173(FLJ42179, CDNA FLJ42179 fis, clone THYMU2030796), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016424(CROP, Cisplatin resistance-associated overexpressed protein), 유전자 등록번호(Genebank) NM_003478(CUL5, Cullin 5), 유전자 등록번호(Genebank) NM_018947(CYCS, Cytochrome c, somatic), 유전자 등록번호(Genebank) BC048797(DFFB, DNA fragmentation factor, 40kDa, beta polypeptide(caspase-activated DNase)), 유전자 등록번호(Genebank) AB209361(FAS, Fas(TNF receptor superfamily, member 6)), 유전자 등록번호(Genebank) NM_006144(GZMA, Granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), 유전자 등록번호(Genebank) BC013326(GAS2, Growth arrest-specific 2), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_005338(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) AK026927(MGC5297, Hypothetical protein MGC5297), 유전자 등록번호(Genebank) AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX648731(JMY, Junction-mediating and regulatory protein), 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) NM_000314(PTEN, Phosphatase and tensin homolog(mutated in multiple advanced cancers 1)), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) BX537500(PDCD4, Programmed cell death 4(neoplastic transformation inhibitor)), 유전자 등록번호(Genebank) NM_013374(PDCD6IP, Programmed cell death 6 interacting protein), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) CR621593(PRG2, Proteoglycan 2, bone marrow(natural killer cell activator, eosinophil granule major basic protein)), 유전자 등록번호(Genebank) BC041849(ROCK1, Rho-associated, coiled-coil containing protein kinase 1), 유전자 등록번호(Genebank) NM_000582(SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)), 유전자 등록번호(Genebank) BC039110(SMNDC1, Survival motor neuron domain containing 1), 유전자 등록번호(Genebank) AB209211(TIA1, TIA1 cytotoxic granule-associated RNA binding protein), 유전자 등록번호(Genebank) AF520785(TNFSF15, Tumor necrosis factor(ligand) superfamily, member 15), 유전자 등록번호(Genebank) NM_002546(TNFRSF11B, Tumor necrosis factor receptor superfamily, member 11b(osteoprotegerin)), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) AB209534(TRA1, Tumor rejection antigen(gp96) 1), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) AB096256(UNC5B, Unc-5 homolog B(C. elegans)), 유전자 등록번호(Genebank) AF055634(UNC5C, Unc-5 homolog C(C. elegans)), 유전자 등록번호(Genebank) AK122953(VDAC1, Voltage-dependent anion channel 1), 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) BC016344(ACPP, Acid phosphatase, prostate), 유전자 등록번호(Genebank) BM921310(ANAPC10, Anaphase promoting complex subunit 10), 유전자 등록번호(Genebank) NM_153186(ANKRD15, Ankyrin repeat domain 15), 유전자 등록번호(Genebank) AY367065(ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)), 유전자 등록번호(Genebank) NM_004071(CLK1, CDC-like kinase 1), 유전자 등록번호(Genebank) CR933728(CDC2 Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_044472(CDC42, Cell division cycle 42(GTP binding protein, 25kDa)), 유전자 등록번호(Genebank) NM_004365(CETN3, Centrin, EF-hand protein, 3(CDC31 homolog, yeast)), 유전자 등록번호(Genebank) NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin)), 유전자 등록번호(Genebank) BC050310(C10orf9, Chromosome 10 open reading frame 9), 유전자 등록번호(Genebank) NM_016446(C9orf127, Chromosome 9 open reading frame 127), 유전자 등록번호(Genebank) AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), 유전자 등록번호(Genebank) NM_001761(CCNF, Cyclin F), 유전자 등록번호(Genebank) NM_004354(CCNG2, Cyclin G2), 유전자 등록번호(Genebank) NM_004064(CDKN1B, Cyclin-dependent kinase inhibitor 1B(p27, Kip1)), 유전자 등록번호(Genebank) NM_007068(DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination(yeast)), 유전자 등록번호(Genebank) AK025142(BPA, dystonin), 유전자 등록번호(Genebank) NM_001950(E2F4, E2F transcription factor 4, p107/p130-binding), 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) AJ245671(EGFL6, EGF-like-domain, multiple 6),전자 등록번호(Genebank) NM_004450(ERH, Enhancer of rudimentary homolog(Drosophila)), 유전자 등록번호(Genebank) AL832041(ESCO1, Establishment of cohesion 1 homolog 1(S. cerevisiae)), 유전자 등록번호(Genebank) AL832666(ESCO2, Establishment of cohesion 1 homolog 2(S. cerevisiae)), 유전자 등록번호(Genebank) AK126048(FLJ44060, FLJ44060 protein), 유전자 등록번호(Genebank) BI494022(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) NM_014707(HDAC9, Histone deacetylase 9), 유전자 등록번호(Genebank) BC067253(FLJ40432, Hypothetical protein FLJ40432), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) BC040410(MAPRE1, Microtubule-associated protein, RP/EB family, member 1), 유 전자 등록번호(Genebank) AB033337(MPHOSPH1, M-phase phosphoprotein 1), 유전자 등록번호(Genebank) L20321(NEK4, NIMA(never in mitosis gene a)-related kinase 4), 유전자 등록번호(Genebank) AJ627032(NIPBL, Nipped-B homolog(Drosophila)), 유전자 등록번호(Genebank) AL575067(NUDC, Nuclear distribution gene C homolog(A. nidulans)), 유전자 등록번호(Genebank) NM_003884(PCAF, P300/CBP-associated factor), 유전자 등록번호(Genebank) AL833922(PAPD5, PAP associated domain containing 5), 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_016205(PDGFC, Platelet derived growth factor C), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), 유전자 등록번호(Genebank) NM_006259(PRKG2, Protein kinase, cGMP-dependent, type II), 유전자 등록번호(Genebank) NM_002709(PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), 유전자 등록번호(Genebank) NM_003463(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BX647606(PTMA, Prothymosin, alpha(gene sequence 28)), 유전자 등록번호(Genebank) BC068483(RINT-1, Rad50-interacting protein 1), 유전자 등록번호(Genebank) NM_006325(RAN, RAN, member RAS oncogene family), 유전자 등록번호(Genebank) NM_213590(RFP2, Ret finger protein 2), 유전자 등록번호(Genebank) NM_006910(RBBP6, Retinoblastoma binding protein 6), 유전자 등록번호(Genebank) BC060806(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) BX648668(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) AB208875(SEPT10, Septin 10), 유전자 등록번호(Genebank) AB209677(SEPT7, Septin 7), 유전자 등록번호(Genebank) BX649128(SESN3, Sestrin 3), 유전자 등록번호(Genebank) XM_497098(LOC441488, Similar to Transcription factor Dp-1(E2F dimerization partner 1)(DRTF1-polypeptide-1)(DRTF1)), 유전자 등록번호(Genebank) AK131071(SLC31A2, Solute carrier family 31(copper transporters), member 2), 유전자 등록번호(Genebank) NM_006930(SKP1A, S-phase kinase-associated protein 1A(p19A)), 유전자 등록번호(Genebank) NM_006542(SPHAR, S-phase response(cyclin-related)), 유전자 등록번호(Genebank) BX647885(STMN1, Stathmin 1/oncoprotein 18), 유전자 등록번호(Genebank) NM_014574(STRN3, Striatin, calmodulin binding protein 3), 유전자 등록번호(Genebank) NM_003176(SYCP1, Synaptonemal complex protein 1), 유전자 등록번호(Genebank) BM674777(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_007375(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_006701(TXNL4A, Thioredoxin-like 4A), 유전자 등록번호(Genebank) NM_030756(TCF7L2, Transcription factor 7-like 2(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) NM_000368(TSC1, Tuberous sclerosis 1), 유전자 등록번호(Genebank) NM_006826(YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide), 유전자 등록번호(Genebank) NM_001032410(USP16, Ubiquitin specific peptidase 16), 유전자 등록번호(Genebank) AK095164(KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_138271(ATRX, Alpha thalassemia/mental retardation syndrome X-linked(RAD54 homolog, S. cerevisiae)), 유전자 등록번호(Genebank) AK025738(ASF1A, ASF1 anti-silencing function 1 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) AK125915(CRY1, Cryptochrome 1(photolyase-like)), 유전자 등록번호(Genebank) S62138(DDIT3, DNA-damage-inducible transcript 3), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) CR936783(FLJ40869, Hypothetical protein LOC284952), 유전자 등록번호(Genebank) NM_002431(MNAT1, Menage a trois 1(CAK assembly factor)), 유전자 등록번호(Genebank) BC032617(POLI, Polymerase(DNA directed) iota), 유전자 등록번호(Genebank) NM_002690(POLB, Polymerase(DNA directed), beta), 유전자 등록번호(Genebank) AK025631(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) BC038996(PMS2L1, Postmeiotic segregation increased 2-like 1), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) NM_020165(RAD18, RAD18 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_152442(RAD9B, RAD9 homolog B(S. cerevisiae)), 유전 자 등록번호(Genebank) NM_018151(RIF1, RAP1 interacting factor homolog(yeast)), 유전자 등록번호(Genebank) AI281523(SFPQ, Splicing factor proline/glutamine-rich(polypyrimidine tract binding protein associated)), 유전자 등록번호(Genebank) AK057830(TOM1L2, Target of myb1-like 2(chicken)), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_001071(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) AK094617(UBE2V2, Ubiquitin-conjugating enzyme E2 variant 2), 유전자 등록번호(Genebank) NM_003337(UBE2B, Ubiquitin-conjugating enzyme E2B(RAD6 homolog)), 유전자 등록번호(Genebank) CD013992(GSTT2, Glutathione S-transferase theta 2), 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) NM_000847(GSTA3, Glutathione S-transferase A3), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_017460(CYP3A4, Cytochrome P450, family 3, subfamily A, polypeptide 4), 유전자 등록번호(Genebank) BC039065(ADH6, Alcohol dehydrogenase 6(class V)), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) NM_000667(ADH1A, Alcohol dehydrogenase 1A(class I), alpha polypeptide), 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) NM_000690(ALDH2, Aldehyde dehydrogenase 2 family(mitochondrial)), 유전자 등록번호(Genebank) NM_000696(ALDH9A1, Aldehyde dehydrogenase 9 family, member A1), 유전자 등록번호(Genebank) AK093311(ACAA2, Acetyl-Coenzyme A acyltransferase 2(mitochondrial 3-oxoacyl-Coenzyme A thiolase)), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) NM_000016(ACADM, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain), 유전자 등록번호(Genebank) BC033517(ACOX2, Acyl-Coenzyme A oxidase 2, branched chain), 유전자 등록번호(Genebank) Z28339(AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)), 유전자 등록번호(Genebank) NM_000384(APOB, Apolipoprotein B(including Ag(x) antigen)), 유전자 등록번호(Genebank) AF285167(ABCA1, ATP-binding cassette, sub-family A(ABC1), member 1), 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_003101(SOAT1, Sterol O-acyltransferase(acyl-Coenzyme A: cholesterol acyltransferase) 1), 유전자 등록번호(Genebank) T81314(MBTPS1, Transcribed locus), 유전자 등록번호(Genebank) NM_147156(TMEM23, Transmembrane protein 23), 유전자 등록번호(Genebank) NM_003916(AP1S2, Adaptor-related protein complex 1, sigma 2 subunit), 유전자 등록번호(Genebank) AA298150(AP3S1, Adaptor-related protein complex 3, sigma 1 subunit), 유전자 등록번호(Genebank) AL109702(AP3S2, Adaptor-related protein complex 3, sigma 2 subunit), 유전자 등록번호(Genebank) BU620136(AP4S1, Adaptor-related protein complex 4, sigma 1 subunit), 유전자 등록번호(Genebank) NM_001025595(ARFIP1, ADP-ribosylation factor interacting protein 1(arfaptin 1)), 유전자 등록번호(Genebank) NM_203437(AFTIPHILIN, Aftiphilin protein), 유전자 등록번호(Genebank) NM_006380(APPBP2, Amyloid beta precursor protein(cytoplasmic tail) binding protein 2), 유전자 등록번호(Genebank) BM683433(AP1GBP1, AP1 gamma subunit binding protein 1), 유전자 등록번호(Genebank) AK027773(APG4C, ATG4 autophagy related 4 homolog C(S. cerevisiae)), 유전자 등록번호(Genebank) AF130117(CRBN, Cereblon), 유전자 등록번호(Genebank) NM_001821(CHML, Choroideremia-like(Rab escort protein 2)), 유전자 등록번호(Genebank) AK002165(DKFZP564O123, Chromatin modifying protein 2B), 유전자 등록번호(Genebank) NM_152284(Shax3, Chromatin modifying protein 4C), 유전자 등록번호(Genebank) AW167080(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) BF790759(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) NM_018229(C14orf108, Chromosome 14 open reading frame 108), 유전자 등록번호(Genebank) AF130062(CLTC, Clathrin, heavy polypeptide(Hc)), 유전자 등록번호(Genebank) AF273058(CTAGE1, Cutaneous T-cell lymphoma-associated antigen 1), 유전자 등록번호(Genebank) AK023846(DER1, Der1-like domain family, member 1), 유전자 등록번호(Genebank) NM_145261(TIM14, DnaJ(Hsp40) homolog, subfamily C, member 19), 유전자 등록번호(Genebank) AF447177(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_004125(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_015171(XPO6, Exportin 6), 유전자 등록번호(Genebank) CA306634(GTF2H3, General transcription factor IIH, polypeptide 3, 34kDa), 유전자 등록번호(Genebank) M57609(GLI3, GLI-Kruppel family member GLI3(Greig cephalopolysyndactyly syndrome)), 유전자 등록번호(Genebank) BC047660(FLJ25422, Hypothetical protein FLJ25422), 유전자 등록번호(Genebank) BC035090(KPNA3, Karyopherin alpha 3(importin alpha 4)), 유전자 등록번호(Genebank) AK093917(KDELR2, KDEL(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2), 유전자 등록번호(Genebank) NM_173827(FLJ38991, Mitochondrial COX18), 유전자 등록번호(Genebank) NM_018698(NXT2, Nuclear transport factor 2-like export factor 2), 유전자 등록번호(Genebank) BC039468(NUP50, Nucleoporin 50kDa), 유전자 등록번호(Genebank) BC032755(PEX13, Peroxisome biogenesis factor 13), 유전자 등록번호(Genebank) AK023223(RAB10, RAB10, member RAS oncogene family), 유전자 등록번호(Genebank) AL162081(RAB14, RAB14, member RAS oncogene family), 유전자 등록번호(Genebank) AB209698(RAB18, RAB18, member RAS oncogene family), 유전자 등록번호(Genebank) NM_031296(RAB33B, RAB33B, member RAS oncogene family), 유전자 등록번호(Genebank) BC014553(RAB3IP, RAB3A interacting protein(rabin3)), 유전자 등록 번호(Genebank) NM_198490(RAB43, RAB43, member RAS oncogene family), 유전자 등록번호(Genebank) NM_004162(RAB5A, RAB5A, member RAS oncogene family), 유전자 등록번호(Genebank) AL136727(RAB6C, RAB6C, member RAS oncogene family), 유전자 등록번호(Genebank) NM_016530(RAB8B, RAB8B, member RAS oncogene family), 유전자 등록번호(Genebank) NM_006267(RANBP2, RAN binding protein 2), 유전자 등록번호(Genebank) NM_020150(SARA1, SAR1 gene homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AA418814(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AA484677(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) NM_031216(SEH1L, SEH1-like(S. cerevisiae)), 유전자 등록번호(Genebank) BC064351(SRP9, Signal recognition particle 9kDa), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) BX648363(SNX10, Sorting nexin 10), 유전자 등록번호(Genebank) AB209439(SNX15, Sorting nexin 15), 유전자 등록번호(Genebank) NM_014758(SNX19, Sorting nexin 19), 유전자 등록번호(Genebank) NM_021249(SNX6, Sorting nexin 6), 유전자 등록번호(Genebank) NM_004782(SNAP29, Synaptosomal-associated protein, 29kDa), 유전자 등록번호(Genebank) AJ420529(STX7, Syntaxin 7), 유전자 등록번호(Genebank) BC028028(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_007269(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_003262(TLOC1, Translocation protein 1), 유전자 등록번호(Genebank) AK094603(FLJ37284, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), 유전자 등록번호(Genebank) AL832866(VPS29, Vacuolar protein sorting 29(yeast)), 유전자 등록번호(Genebank) AK092532(FLJ10979, Vacuolar protein sorting 53(yeast)), 유전자 등록번호(Genebank) NM_015336(ZDHHC17, Zinc finger, DHHC-type containing 17), 유전자 등록번호(Genebank) AB002303(ZFYVE16, Zinc finger, FYVE domain containing 16), 유전자 등록번호(Genebank) NM_007236(CHP, Calcium binding protein P22), 유전자 등록번호(Genebank) AL137653(BARS, C-terminal binding protein 1), 유전자 등록번호(Genebank) AB017363(FZD1, Frizzled homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_017412(FZD3, Frizzled homolog 3(Drosophila)), 유전자 등록번호(Genebank) AB032417(FZD4, Frizzled homolog 4(Drosophila)), 유전자 등록번호(Genebank) AK125150(MAPK8, Mitogen-activated protein kinase 8), 유전자 등록번호(Genebank) AK025758(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_000933(PLCB4, Phospholipase C, beta 4), 유전자 등록번호(Genebank) AK131561(PRKACA, Protein kinase, cAMP-dependent, catalytic, alpha), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) BC078170(WNT2, Wingless-type MMTV integration site family member 2), 유전자 등록번호(Genebank) NM_003392(WNT5A, Wingless-type MMTV integration site family, member 5A), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) AL832664(ANP32E, Acidic(leucine-rich) nuclear phosphoprotein 32 family, member E), 유전자 등록번호(Genebank) NM_138448(ACYP2, Acylphosphatase 2, muscle type), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) NM_175873(LOC134548, Ankyrin repeat domain 43), 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) AB013380(ABCB10, ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) M75106(CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)), 유전자 등록번호(Genebank) AK131472(FLJ16640, CDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BC004543(C15orf23, Chromosome 15 open reading frame 23), 유전자 등록번호(Genebank) NM_001012507(C6orf173, Chromosome 6 open reading frame 173), 유전자 등록번호(Genebank) AK000972(C9orf40, Chromosome 9 open reading frame 40), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_018204(CKAP2, Cytoskeleton associated protein 2), 유전자 등록번호(Genebank) NM_006716(ASK, DBF4 homolog(S. cerevisiae)), 유 전자 등록번호(Genebank) BC045541(LOC200895, Dihydrofolate reductase-like 1), 유전자 등록번호(Genebank) NM_152721(DOK6, Docking protein 6), 유전자 등록번호(Genebank) NM_017645(FAM29A, Family with sequence similarity 29, member A), 유전자 등록번호(Genebank) NM_207418(MGC57827, Family with sequence similarity 72, member A), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) NM_005141(FGB, Fibrinogen beta chain), 유전자 등록번호(Genebank) AB208919(FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)), 유전자 등록번호(Genebank) NM_032117(GAJ, GAJ protein), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) AB007893(KIAA0433, Histidine acid phosphatase domain containing 1), 유전자 등록번호(Genebank) AF032862(HMMR, Hyaluronan-mediated motility receptor(RHAMM)), 유전자 등록번호(Genebank) AK123495(Q5XI42, Hypothetical gene supported by AL713796), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) AL832022(FLJ13910, Hypothetical protein FLJ13910), 유전자 등록번호(Genebank) AL832208(FLJ32312, Hypothetical protein FLJ32312), 유전자 등록번호(Genebank) AB037805(KLHL14, Kelch-like 14(Drosophila)), 유전자 등록번호(Genebank) NM_014736(KIAA0101, KIAA0101), 유전자 등록번호(Genebank) AB046861(KIAA1641, KIAA1641), 유전자 등록번호(Genebank) BC033021(LOC152831, Klotho beta), 유전자 등록번호(Genebank) NM_182551(LYCAT, Lysocardiolipin acyltransferase), 유전자 등록번호(Genebank) NM_002381(MATN3, Matrilin 3), 유전자 등록번호(Genebank) AB018342(MYO10, Myosin X), 유전자 등록번호(Genebank) BX537509(NET1, Neuroepithelial cell transforming gene 1), 유전자 등록번호(Genebank) BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X)-type motif 21), 유전자 등록번호(Genebank) NM_033222(PSIP1, PC4 and SFRS1 interacting protein 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_176869(PPA2, Pyrophosphatase(inorganic) 2), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_004586(RPS6KA3, Ribosomal protein S6 kinase, 90kDa, polypeptide 3), 유전자 등록번호(Genebank) BC064610(SEPHS1, Selenophosphate synthetase 1), 유전자 등록번호(Genebank) AK075271(SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)), 유전자 등록번호(Genebank) XM_496355(LOC440577, Similar to nucleophosmin 1), 유전자 등록번호(Genebank) XM_371758(LOC389308, Similar to ribosomal protein L10a), 유전자 등록번호(Genebank) XM_371470(LOC388907, Similar to ribosomal protein L5; 60S ribosomal protein L5), 유전자 등록번호(Genebank) XM_495961(LOC440145, Similar to RIKEN cDNA 2410129H14), 유전자 등록번호(Genebank) XM_496301(LOC440517, Similar to zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_180991(SLCO4C1, Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spc25, Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BM458612(THRAP6, Thyroid hormone receptor associated protein 6), 유전자 등록번호(Genebank) AI300182(PROS1, Transcribed locus, weakly similar to NP_000304.1 protein S(alpha)), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AY358727(FLJ21934, UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) BC035579(ZNF100, Zinc finger protein 100), 유전자 등록번호(Genebank) AB209664(ZNF195, Zinc finger protein 195), 유전자 등록번호(Genebank) AY269786(ZNF429, Zinc finger protein 429), 유전자 등록번호(Genebank) NM_003423(ZNF43, Zinc finger protein 43(HTF6)), 유전자 등록번호(Genebank) NM_016220(ZNF588, Zinc finger protein 588), 유전자 등록번호(Genebank) AK122869(LOC148213, Zinc finger protein 681), 유전자 등록번호(Genebank) AK131527(ZNF15L1, Zinc finger protein 708(KOX8)), 유전자 등록번호(Genebank) NM_003430(ZNF91, Zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) NM_152626(ZNF92, Zinc finger protein 92(HTF12)).
1) 상기 바이오마커 중에서 나프탈렌의 노출에 의해 발현이 증가하는 바이오 마커 유전자는 하기와 같다:
유전자 등록번호(Genebank) BC063507(HSPA1B, Heat shock 70kDa protein 1B), 유전자 등록번호(Genebank) NM_016639(TNFRSF12A, Tumor necrosis factor receptor superfamily, member 12A), 유전자 등록번호(Genebank) NM_033027(AXUD1, AXIN1 up-regulated 1), 유전자 등록번호(Genebank) AF332558(BBC3, BCL2 binding component 3), 유전자 등록번호(Genebank) NM_138639(BCL2L12, BCL2-like 12(proline rich)), 유전자 등록번호(Genebank) AK124526(BCAR1, Breast cancer anti-estrogen resistance 1), 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016222(DDX41, DEAD(Asp-Glu-Ala-Asp) box polypeptide 41), 유전자 등록번호(Genebank) NM_022105(DATF1, Death inducer-obliterator 1), 유전자 등록번호(Genebank) AK127033(DNM2, Dynamin 2), 유전자 등록번호(Genebank) NM_152461(ERN1, Endoplasmic reticulum to nucleus signalling 1), 유전자 등록번호(Genebank) NM_003806(HRK, Harakiri, BCL2 interacting protein(contains only BH3 domain)), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) NM_003639(IKBKG, Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma), 유전자 등록번호(Genebank) BX640923(MDM4, Mdm4, transformed 3T3 cell double minute 4, p53 binding protein(mouse)), 유전자 등록번호(Genebank) NM_002648(PIM1, Pim-1 oncogene), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_004309(ARHGDIA, Rho GDP dissociation inhibitor(GDI) alpha), 유전자 등록번호(Genebank) BC041022(SCAND1, SCAN domain containing 1), 유전자 등록번호(Genebank) NM_006282(STK4, Serine/threonine kinase 4), 유전자 등록번호(Genebank) AB005666(SIPA1, Signal-induced proliferation-associated gene 1), 유전자 등록번호(Genebank) NM_207111(TRIAD3, TRIAD3 protein), 유전자 등록번호(Genebank) AY247738(TRIB3, Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AF026071(TNFRSF25, Tumor necrosis factor receptor superfamily, member 25), 유전자 등록번호(Genebank) AB209485(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) CR606241(ACTG1, Actin, gamma 1), 유전자 등록번호(Genebank) NM_012127(CIZ1, CDKN1A interacting zinc finger protein 1), 유전자 등록번호(Genebank) AK057576(CHFR, Checkpoint with forkhead and ring finger domains), 유전자 등록번호(Genebank) NM_005255(GAK, Cyclin G associated kinase), 유전자 등록번호(Genebank) NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) AK094316(MAD2L2, MAD2 mitotic arrest deficient-like 2(yeast)), 유전자 등록번호(Genebank) NM_002595(PCTK2, PCTAIRE protein kinase 2), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), 유전자 등록번호(Genebank) X06374(PDGFA, Platelet-derived growth factor alpha polypeptide), 유전자 등록번호(Genebank) NM_001722(POLR3D, Polymerase(RNA) III(DNA directed) polypeptide D, 44kDa), 유전자 등록번호(Genebank) NM_002808(PSMD2, Proteasome(prosome, macropain) 26S subunit, non-ATPase, 2), 유전자 등록번호(Genebank) BC038504(SNF1LK, SNF1-like kinase), 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) NM_000548(TSC2, Tuberous sclerosis 2), 유전자 등록번호(Genebank) AK223618(ZBTB17, Zinc finger and BTB domain containing 17), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) AY258066(OKL38, Pregnancy-induced growth inhibitor), 유전자 등록번호(Genebank) NM_001012661(SLC3A2, Solute carrier family 3(activators of dibasic and neutral amino acid transport), member 2), 유전자 등록번호(Genebank) NM_014598(SOCS7, Suppressor of cytokine signaling 7), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) NM_015366(FLJ20185, Rho GTPase activating protein 8), 유전자 등록번호(Genebank) AB209322(SEMA3B, Sema domain, immunoglobulin domain(Ig), short basic domain, secreted,(semaphorin) 3B), 유전자 등록번호(Genebank) AB209463(CSNK1D, Casein kinase 1, delta), 유전자 등록번호(Genebank) NM_005228(EGFR, Epidermal growth factor receptor(erythroblastic leukemia viral(v-erb-b) oncogene homolog, avian)), 유전자 등록번호(Genebank) BC089041(GNA11, Guanine nucleotide binding protein(G protein), alpha 11(Gq class)), 유전자 등록번호(Genebank) NM_002224(ITPR3, Inositol 1,4,5-triphosphate receptor, type 3), 유전자 등록번호(Genebank) NM_012463(ATP6V0A2, ATPase, H+transport -ing, lysosomal V0 subunit a isoform 2), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) NM_000574(DAF, Decay accelerating factor for complement(CD55, Cromer blood group system)), 유전자 등록번호(Genebank) NM_001421(ELF4, E74-like factor 4(ets domain transcription factor)), 유전자 등록번호(Genebank) BG171626(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) BM905227(FTH1, Ferritin, heavy polypeptide 1), 유전자 등록번호(Genebank) NM_001015053(HDAC5, Histone deacetylase 5), 유전자 등록번호(Genebank) NM_003641(IFITM1, Interferon induced transmembrane protein 1(9-27)), 유전자 등록번호(Genebank) AF200496(IL1F7, Interleukin 1 family, member 7(zeta)), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) NM_000565(IL6R, Interleukin 6 receptor), 유전자 등록번호(Genebank) NM_031483(ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)), 유전자 등록번호(Genebank) NM_001300(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) AB209647(NCF2, Neutrophil cytosolic factor 2(65kDa, chronic granulomatous disease, autosomal 2)), 유전자 등록번호(Genebank) NM_017670(OTUB1, OTU domain, ubiquitin aldehyde binding 1), 유전자 등록번호(Genebank) NM_139276(STAT3, Signal transducer and activator of transcription 3(acute-phase response factor)), 유전자 등록번호(Genebank) NM_003037(SLAMF1, Signaling lymphocytic activation molecule family member 1), 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) NM_001353(AKR1C1, Aldo-keto reductase family 1, member C1(dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase)), 유전자 등록번호(Genebank) NM_001769(CD9, CD9 antigen(p24)), 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK095781(CIRBP, Cold inducible RNA binding protein), 유전자 등록번호(Genebank) X14789(CRYAA, Crystallin, alpha A), 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_080927(DCBLD2, Discoidin, CUB and LCCL domain containing 2), 유전자 등록번호(Genebank) AY253982(GPR54, G protein-coupled receptor 54), 유전자 등록번호(Genebank) AF073799(GALR3, Galanin receptor 3), 유전자 등록번호(Genebank) BI767815(GP9, Glycoprotein IX(platelet)), 유전자 등록번호(Genebank) NM_007353(GNA12, Guanine nucleotide binding protein(G protein) alpha 12), 유전자 등록번호(Genebank) CR623806(HSPA6, Heat shock 70kDa protein 6(HSP70B')), 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK000252(FLJ20245, Hypothetical protein FLJ20245), 유전자 등록번호(Genebank) AK057577(IRF3, Interferon regulatory factor 3), 유전자 등록번호(Genebank) L76191(IRAK1, Interleukin-1 receptor-associated kinase 1), 유전자 등록번호(Genebank) BC053882(MT1X, Metallothionein 1X), 유전자 등록번호(Genebank) AK124709(NDRG1, N-myc downstream regulated gene 1), 유전자 등록번호(Genebank) NM_002658(PLAU, Plasminogen activator, urokinase), 유전자 등록번호(Genebank) U02389(PRSS15, Protease, serine, 15), 유전자 등록번호(Genebank) NM_005053(RAD23A, RAD23 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) CD357517(Unknown, Similar to Interferon-induced transmembrane protein 3(Interferon-inducible protein 1-8U)), 유전자 등록번호(Genebank) NM_032038(SPINL, Spinster), 유전자 등록번호(Genebank) H18681(C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BX648190(WDR1, WD repeat domain 1), 유전자 등록번호(Genebank) AK074035(XAB2, XPA binding protein 2), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_017572(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_030662(MAP2K2, Mitogen-activated protein kinase kinase 2), 유전자 등록번호(Genebank) AB208849(SHC1, SHC(Src homology 2 domain containing) transforming protein 1), 유전자 등록번호(Genebank) NM_138473(SP1, Sp1 transcription factor), 유전자 등록번호(Genebank) X02812(TGFB1, Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_002880(RAF1, V-raf-1 murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_152221(CSNK1E, Casein kinase 1, epsilon), 유전자 등록번호(Genebank) AB209210(DVL1, Dishevelled, dsh homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) AF077820(LRP5, Low density lipoprotein receptor-related protein 5), 유전자 등록번호(Genebank) NM_033119(NKD1, Naked cuticle homolog 1(Drosophila)), 유전자 등록번호(Genebank) AK090488(PPP2R1A, Protein phosphatase 2(formerly 2A), regulatory subunit A(PR 65), alpha isoform), 유전자 등록번호(Genebank) AL834166(TCF7, Transcription factor 7(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003255(TIMP2, TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_014595(NT5C, 5', 3'-nucleotidase, cytosolic), 유전자 등록번호(Genebank) AY461712(ATP13A2, ATPase type 13A2), 유전자 등록번호(Genebank) NM_018590(GALNACT-2, Chondroitin sulfate GalNAcT-2), 유전자 등록번호(Genebank) NM_080757(C20orf127, Chromosome 20 open reading frame 127), 유전자 등록번호(Genebank) X16866(CYP2D7P1, Cytochrome P450, family 2, subfamily D, polypeptide 6), 유전자 등록번호(Genebank) NM_000782(CYP24A1, Cytochrome P450, family 24, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) AK096809(CYP4F8, Cytochrome P450, family 4, subfamily F, polypeptide 8), 유전자 등록번호(Genebank) NM_000786(CYP51A1, Cytochrome P450, family 51, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_017556(FBLP-1, Filamin binding LIM protein 1), 유전자 등록번호(Genebank) AK093560(INPP1, Inositol polyphosphate-1-phosphatase), 유전자 등록번호(Genebank) NM_005578(LPP, LIM domain containing preferred translocation partner in lipoma), 유전자 등록번호(Genebank) AK222601(MMP10, Matrix metallopeptidase 10(stromelysin 2)), 유전자 등록번호(Genebank) NM_005947(MT1B, Metallothionein 1B(functional)), 유전자 등록번호(Genebank) BC048334(MT1G, Metallothionein 1G), 유전자 등록번호(Genebank) BI488702(MT1K, Metallothionein 1M), 유전자 등록번호(Genebank) NM_182924(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK127759(NDUFS7, NADH dehydrogenase(ubiquinone) Fe-S protein 7, 20kDa(NADH- coenzyme Q reductase)), 유전자 등록번호(Genebank) NM_203353(PDLIM7, PDZ and LIM domain 7(enigma)), 유전자 등록번호(Genebank) NM_002627(PFKP, Phosphofructokinase, platelet), 유전자 등록번호(Genebank) AA862994(S100A3, S100 calcium binding protein A3), 유전자 등록번호(Genebank) NM_003461(ZYX, Zyxin), 유전자 등록번호(Genebank) NM_019112(ABCA7, ATP-binding cassette, sub-family A(ABC1), member 7), 유전자 등록번호(Genebank) AB209054(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) U49248(ABCC2, ATP-binding cassette, sub-family C(CFTR/MRP), member 2), 유전자 등록번호(Genebank) NM_020038(ABCC3, ATP-binding cassette, sub-family C(CFTR/MRP), member 3), 유전자 등록번호(Genebank) BC025358(ABCD1, ATP-binding cassette, sub-family D(ALD), member 1), 유전자 등록번호(Genebank) NM_003992(CLK3, CDC-like kinase 3), 유전자 등록번호(Genebank) AK128154(C9orf86, Chromosome 9 open reading frame 86), 유전자 등록번호(Genebank) BC006404(SKD3, ClpB caseinolytic peptidase B homolog(E. coli)), 유전자 등록번호(Genebank) BC067254(COASY, Coenzyme A synthase), 유전자 등록번호(Genebank) NM_004398(DDX10, DEAD(Asp-Glu-Ala-Asp) box polypeptide 10), 유전자 등록번호(Genebank) BC038417(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_138614(DHX30, DEAH(Asp-Glu-Ala-His) box polypeptide 30), 유전자 등록번호(Genebank) NM_032656(DHX37, DEAH(Asp-Glu-Ala-His) box polypeptide 37), 유전자 등록번호(Genebank) NM_020812(DOCK6, Dedicator of cytokinesis 6), 유전자 등록번호(Genebank) NM_004431(EPHA2, EPH receptor A2), 유전자 등록번호(Genebank) NM_001961(EEF2, Eukaryotic translation elongation factor 2), 유전자 등록번호(Genebank) NM_003751(EIF3S9, Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa), 유전자 등록번호(Genebank) AF114818(SIAHBP1, Fuse-binding protein-interacting repressor), 유전자 등록번호(Genebank) NM_019096(GTPBP2, GTP binding protein 2), 유전자 등록번호(Genebank) NM_006572(GNA13, Guanine nucleotide binding protein(G protein), alpha 13), 유전자 등록번호(Genebank) AK128226(HK1, Hexokinase 1), 유전자 등록번호(Genebank) BC069201(FLJ22761, Hexokinase domain containing 1), 유전자 등록번호(Genebank) NM_006546(IMP-1, IGF-II mRNA-binding protein 1), 유전자 등록번호(Genebank) NM_015155(KIAA0217, La ribonucleoprotein domain family, member 5), 유전자 등록번호(Genebank) NM_018357(FLJ11196, La ribonucleoprotein domain family, member 6), 유전자 등록번호(Genebank) AK127089(MTHFD1L, Methylenetetrahydrofolate dehydrogenase(NADP+ dependent) 1-like), 유전자 등록번호(Genebank) XM_038150(MAST3, Microtubule associated serine/threonine kinase 3), 유전자 등록번호(Genebank) AB058686(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) BC027875(MYO15B, Myosin XVB pseudogene), 유전자 등록번호(Genebank) K122664(NRBP, Nuclear receptor binding protein), 유전자 등록번호(Genebank) NM_001001852(PIM3, Pim-3 oncogene), 유전자 등록번호(Genebank) BC094766(PKN1, Protein kinase N1), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_019034(RHOF, Ras homolog gene family, member F(in filopodia)), 유전자 등록번호(Genebank) NM_016084(RASD1, RAS, dexamethasone-induced 1), 유전자 등록번호(Genebank) AY369207(RBPMS2, RNA binding protein with multiple splicing 2), 유전자 등록번호(Genebank) BC069233(SCYL1, SCY1-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AB209553(STK11, Serine/threonine kinase 11), 유전자 등록번호(Genebank) AK124047(C20orf119, Similar to embryonic poly(A) binding protein), 유전자 등록번호(Genebank) XM_496374(LOC440595, Similar to eukaryotic translation elongation factor 1 alpha 1), 유전자 등록번호(Genebank) NM_005094(SLC27A4, Solute carrier family 27(fatty acid transporter), member 4) 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) NM_025195(TRIB1, Tribbles homolog 1(Drosophila)), 유전자 등록번호(Genebank) BC009900(UBE1, Ubiquitin-activating enzyme E1(A1S9T and BN75 temperature sensitivity complementing)), 유전자 등록번호(Genebank) AF045458(ULK1, Unc-51-like kinase 1(C. elegans)), 유전자 등록번호(Genebank) X59303(VARS2, Valyl-tRNA synthetase), 유전자 등록번호(Genebank) AB209808(AP1M1, Adaptor-related protein complex 1, mu 1 subunit), 유전자 등록번호(Genebank) AB208804(AP3D1, Adaptor-related protein complex 3, delta 1 subunit), 유전자 등록번호(Genebank) BC000786(ARFGAP1, ADP- ribosylation factor GTPase activating protein 1), 유전자 등록번호(Genebank) AK125277(APG4B, ATG4 autophagy related 4 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_007097(CLTB, Clathrin, light polypeptide(Lcb)), 유전자 등록번호(Genebank) AK091056(COBRA1, Cofactor of BRCA1), 유전자 등록번호(Genebank) AF349676(COG3, Component of oligomeric golgi complex 3), 유전자 등록번호(Genebank) AB002368(XPO6, Exportin 6), 유전자 등록번호(Genebank) BX648781(GABARAPL1, GABA(A) receptor-associated protein like 1), 유전자 등록번호(Genebank) AK123405(GDI1, GDP dissociation inhibitor 1), 유전자 등록번호(Genebank) NM_004712(HGS, Hepatocyte growth factor-regulated tyrosine kinase substrate), 유전자 등록번호(Genebank) AK094897(IPO4, Importin 4), 유전자 등록번호(Genebank) L38951(KPNB1, Karyopherin(importin) beta 1), 유전자 등록번호(Genebank) NM_002268(KPNA4, Karyopherin alpha 4(importin alpha 3)), 유전자 등록번호(Genebank) AY014403(KIF13A, Kinesin family member 13A), 유전자 등록번호(Genebank) NM_002867(RAB3B, RAB3B, member RAS oncogene family), 유전자 등록번호(Genebank) AK025300(RANBP3, RAN binding protein 3), 유전자 등록번호(Genebank) AB014551(ARHGEF2, Rho/rac guanine nucleotide exchange factor(GEF) 2), 유전자 등록번호(Genebank) CD049342(RPL23, Ribosomal protein L23), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) NM_006809(TOMM34, Translocase of outer mitochondrial membrane 34), 유전자 등 록번호(Genebank) BC047528(TOMM40, Translocase of outer mitochondrial membrane 40 homolog(yeast)), 유전자 등록번호(Genebank) AK056701(VPS11, Vacuolar protein sorting 11(yeast)), 유전자 등록번호(Genebank) BC042390(VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) AK095154(AES, Amino-terminal enhancer of split), 유전자 등록번호(Genebank) BC060828(ARID3A, AT rich interactive domain 3A(BRIGHT- like)), 유전자 등록번호(Genebank) NM_003670(BHLHB2, Basic helix-loop-helix domain containing, class B, 2), 유전자 등록번호(Genebank) NM_006442(DRAP1, DR1-associated protein 1(negative cofactor 2 alpha)), 유전자 등록번호(Genebank) NM_006532(ELL, Elongation factor RNA polymerase II), 유전자 등록번호(Genebank) NM_001991(EZH1, Enhancer of zeste homolog 1(Drosophila)), 유전자 등록번호(Genebank) U18018(ETV4, Ets variant gene 4(E1A enhancer binding protein, E1AF)), 유전자 등록번호(Genebank) NM_002018(FLII, Flightless I homolog(Drosophila)), 유전자 등록번호(Genebank) NM_181430(FOXK2, Forkhead box K2), 유전자 등록번호(Genebank) NM_001012426(FOXP4, Forkhead box P4), 유전자 등록번호(Genebank) BC053850(FOXQ1, Forkhead box Q1), 유전자 등록번호(Genebank) AF176422(HEY1, Hairy/enhancer-of-split related with YRPW motif 1), 유전자 등록번호(Genebank) BC078664(HMGA1, High mobility group AT-hook 1), 유전자 등록번호(Genebank) XM_379934(KIAA1718, KIAA1718 protein), 유전자 등록번호(Genebank) BC069156(LBX1, Ladybird homeobox homolog 1(Drosophila)), 유전 자 등록번호(Genebank) NM_014520(MYBBP1A, MYB binding protein(P160) 1a), 유전자 등록번호(Genebank) NM_002518(NPAS2, Neuronal PAS domain protein 2), 유전자 등록번호(Genebank) NM_001001716(NFKBIB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta), 유전자 등록번호(Genebank) AF087856(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002653(PITX1, Paired-like homeodomain transcription factor 1), 유전자 등록번호(Genebank) NM_001003891(PCQAP, PC2(positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein), 유전자 등록번호(Genebank) NM_005035(POLRMT, Polymerase(RNA) mitochondrial(DNA directed)), 유전자 등록번호(Genebank) NM_012448(STAT5B, Signal transducer and activator of transcription 5B), 유전자 등록번호(Genebank) CR607342(RNPS1, Similar to splicing-related factor RNPS1), 유전자 등록번호(Genebank) NM_005986(SOX1, SRY(sex determining region Y)-box 1), 유전자 등록번호(Genebank) NM_003072(SMARCA4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), 유전자 등록번호(Genebank) NM_006951(TAF5, TAF5 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 100kDa), 유전자 등록번호(Genebank) NM_152380(TBX15, T-box 15), 유전자 등록번호(Genebank) NM_016569(TBX3, T-box 3(ulnar mammary syndrome)), 유전자 등록번호(Genebank) BC006396(TLX2, T-cell leukemia, homeobox 2), 유전자 등록번호(Genebank) AF106934(THRAP5, Thyroid hormone receptor associated protein 5), 유전자 등록번호(Genebank) AF108461(UBN1, Ubinuclein 1), 유전자 등록번호(Genebank) NM_002359(MAFG, V-maf musculoaponeurotic fibrosarcoma oncogene homolog G(avian)), 유전자 등록번호(Genebank) AK092414(MAFK, V-maf musculoaponeurotic fibrosarcoma oncogene homolog K(avian)), 유전자 등록번호(Genebank) AK128553(ZZANK1, Mindbomb homolog 2(Drosophila)), 유전자 등록번호(Genebank) NM_001003694(BRPF1, Bromodomain and PHD finger containing, 1), 유전자 등록번호(Genebank) CR936799(FHL2, Four and a half LIM domains 2), 유전자 등록번호(Genebank) NM_139201(GIT2, G protein-coupled receptor kinase interactor 2), 유전자 등록번호(Genebank) AK125974(p66alpha, GATA zinc finger domain containing 2A), 유전자 등록번호(Genebank) CB050471(GLI4, GLI-Kruppel family member GLI4), 유전자 등록번호(Genebank) NM_006734(HIVEP2, Human immunodeficiency virus type I enhancer binding protein 2), 유전자 등록번호(Genebank) NM_031297(DKFZP761H1710, Hypothetical protein DKFZp761H1710), 유전자 등록번호(Genebank) NM_024671(FLJ23436, Hypothetical protein FLJ23436), 유전자 등록번호(Genebank) NM_173680(MGC33584, Hypothetical protein MGC33584), 유전자 등록번호(Genebank) NM_031918(KLF16, Kruppel-like factor 16), 유전자 등록번호(Genebank) BU163740(MKRN1, Makorin, ring finger protein, 1), 유전자 등록번호(Genebank) NM_005885(MARCH-V, Membrane-associated ring finger(C3HC4) 6), 유전자 등록번호(Genebank) AF242768(LOC51333, Mesenchymal stem cell protein DSC43), 유전자 등록번호(Genebank) NM_020774(MIB1, Mindbomb homolog 1(Drosophila)), 유전자 등록번호(Genebank) AJ007041(MLL4, Myeloid/lymphoid or mixed-lineage leukemia 4), 유전자 등록번호(Genebank) BF206103(ZNF286, Peroxisome proliferative activated receptor, alpha-like), 유전자 등록번호(Genebank) BC008834(PHF1, PHD finger protein 1), 유전자 등록번호(Genebank) D87076(PHF15, PHD finger protein 15), 유전자 등록번호(Genebank) NM_020122(KCMF1, Potassium channel modulatory factor 1), 유전자 등록번호(Genebank) NM_145214(TRIM11, Tripartite motif-containing 11), 유전자 등록번호(Genebank) NM_033452(TRIM47, Tripartite motif-containing 47), 유전자 등록번호(Genebank) AF281046(TRIM8, Tripartite motif-containing 8), 유전자 등록번호(Genebank) BC004256(ZNF259, Zinc finger protein 259), 유전자 등록번호(Genebank) CR597101(ZFP36, Zinc finger protein 36, C3H type, homolog(mouse)), 유전자 등록번호(Genebank) NM_198055(ZNF42, Zinc finger protein 42(myeloid-specific retinoic acid-responsive)), 유전자 등록번호(Genebank) BC071620(ZNF581, Zinc finger protein 581), 유전자 등록번호(Genebank) BM544755(ZNF593, Zinc finger protein 593), 유전자 등록번호(Genebank) AK024487(ZNF598, Zinc finger protein 598), 유전자 등록번호(Genebank) BC089449(ZEC, Zinc finger protein 628), 유전자 등록번호(Genebank) NM_153813(ZFPM1, Zinc finger protein, multitype 1), 유전자 등록번호(Genebank) BM451410(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BX648551(ZA20D2, Zinc finger, A20 domain containing 2), 유전자 등록번호(Genebank) BC006340(ZCCHC2, Zinc finger, CCHC domain containing 2), 유전자 등록번호(Genebank) BC053544(ZDHHC8, Zinc finger, DHHC-type containing 8), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BQ939577(AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)), 유전자 등록번호(Genebank) AB045292(TMEM8, Transmembrane protein 8(five membrane-spanning domains)), 유전자 등록번호(Genebank) NM_012088(PGLS, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) NM_184041(ALDOA, Aldolase A, fructose-bisphosphate), 유전자 등록번호(Genebank) NM_000402(G6PD, Glucose-6-phosphate dehydrogenase), 유전자 등록번호(Genebank) NM_006715(MAN2C1, Mannosidase, alpha, class 2C, member 1), 유전자 등록번호(Genebank) CR597860(C19orf27, Chromosome 19 open reading frame 27), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) BC042195(MT, Malonyl-CoA:acyl carrier protein transacylase, mitochondrial), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) AK057049(PTGES2, Prostaglandin E synthase 2), 유전자 등록번호(Genebank) AB046825(GBA2, Glucosidase, beta(bile acid) 2), 유전자 등록번호(Genebank) BC033110(HSD17B1, Hydroxysteroid(17-beta) dehydrogenase 1), 유전자 등록번호(Genebank) BC050553(NTE, Neuropathy target esterase), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) NM_005028(PIP5K2A, Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha), 유전자 등록번호(Genebank) BC007612(PSAP, Prosaposin(variant Gaucher disease and variant metachromatic leukodystrophy)), 유전자 등록번호(Genebank) BC087612(SBF1, SET binding factor 1), 유전자 등록번호(Genebank) BQ683841(S100A11, S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) CK000930(HIST1H2AI, Histone 1, H2ai), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) BC069193(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK223291(MMP3, Matrix metallopeptidase 3(stromelysin 1, progelatinase)), 유전자 등록번호(Genebank) NM_178819(DKFZp586M1819, 1-acylglycerol-3-phosphate O-acyltransferase 6(lysophosphatidic acid acyltransferase, zeta)), 유전자 등록번호(Genebank) NM_018694(ARL6IP4, ADP-ribosylation-like factor 6 interacting protein 4), 유전자 등록번호(Genebank) BC014895(MGC10204, Aldehyde dehydrogenase 16 family, member A1), 유전자 등록번호(Genebank) NM_032468(ASPH, Aspartate beta-hydroxylase), 유전자 등록번 호(Genebank) BC008751(CAPN1, Calpain 1,(mu/I) large subunit), 유전자 등록번호(Genebank) AK128552(CAPN10, Calpain 10), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) NM_001903(CTNNA1, Catenin(cadherin-associated protein), alpha 1, 102kDa), 유전자 등록번호(Genebank) BC067289(CTSL2, Cathepsin L2), 유전자 등록번호(Genebank) NM_015151(C21orf106, Chromosome 21 open reading frame 106), 유전자 등록번호(Genebank) NM_031434(C7orf21, Chromosome 7 open reading frame 21), 유전자 등록번호(Genebank) NM_001303(COX10, COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase(yeast)), 유전자 등록번호(Genebank) BP317375(COX6A2, Cytochrome c oxidase subunit VIa polypeptide 2), 유전자 등록번호(Genebank) NM_001355(DDT, D-dopachrome tautomerase), 유전자 등록번호(Genebank) NM_032482(DOT1L, DOT1-like, histone H3 methyltransferase(S. cerevisiae)), 유전자 등록번호(Genebank) NM_004419(DUSP5, Dual specificity phosphatase 5), 유전자 등록번호(Genebank) AB210013(EIF4G1, Eukaryotic translation initiation factor 4 gamma, 1), 유전자 등록번호(Genebank) NM_020158(EXOSC5, Exosome component 5), 유전자 등록번호(Genebank) NM_178225(FBXW5, F-box and WD-40 domain protein 5), 유전자 등록번호(Genebank) NM_058229(FBXO32, F-box protein 32), 유전자 등록번호(Genebank) AB209592(GMPPA, GDP-mannose pyrophosphorylase A), 유전자 등록번호(Genebank) AJ002231(GNPDA1, Glucosamine-6-phosphate deaminase 1), 유전자 등록번 호(Genebank) AK094940(GCLC, Glutamate-cysteine ligase, catalytic subunit), 유전자 등록번호(Genebank) NM_005318(H1F0, H1 histone family, member 0), 유전자 등록번호(Genebank) NM_004639(BAT3, HLA-B associated transcript 3), 유전자 등록번호(Genebank) NM_032717(MGC11324, Hypothetical protein MGC11324), 유전자 등록번호(Genebank) BX647357(IDS, Iduronate 2-sulfatase(Hunter syndrome)), 유전자 등록번호(Genebank) AY923172(KLK13, Kallikrein 13), 유전자 등록번호(Genebank) AK023137(MGAT4B, Mannosyl(alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B), 유전자 등록번호(Genebank) NM_024864(FLJ22578, Mitochondrial rRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_153006(NAGS, N-acetylglutamate synthase), 유전자 등록번호(Genebank) NM_020230(PPAN, Peter pan homolog(Drosophila)), 유전자 등록번호(Genebank) BC017045(PYGB, Phosphorylase, glycogen; brain), 유전자 등록번호(Genebank) NM_005401(PTPN14, Protein tyrosine phosphatase, non-receptor type 14), 유전자 등록번호(Genebank) AF290614(PTPN23, Protein tyrosine phosphatase, non-receptor type 23), 유전자 등록번호(Genebank) BX648253(PTPN3, Protein tyrosine phosphatase, non-receptor type 3), 유전자 등록번호(Genebank) NM_002840(PTPRF, Protein tyrosine phosphatase, receptor type, F), 유전자 등록번호(Genebank) D15049(PTPRH, Protein tyrosine phosphatase, receptor type, H), 유전자 등록번호(Genebank) AF348492(RBAF600, Retinoblastoma-associated factor 600), 유전자 등록번 호(Genebank) BM926478(RBP1, Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) AB209196(RNH, Ribonuclease/angiogenin inhibitor 1), 유전자 등록번호(Genebank) CR619918(RPL18A, Ribosomal protein L18a), 유전자 등록번호(Genebank) BM553074(RPS15A, Ribosomal protein S15a), 유전자 등록번호(Genebank) CD387408(RPS28, Ribosomal protein S28), 유전자 등록번호(Genebank) CR749837(RPS7, Ribosomal protein S7), 유전자 등록번호(Genebank) BM805682(EEF1D, Similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein), 유전자 등록번호(Genebank) XM_069734(LOC136143, Similar to ribosomal protein L18; 60S ribosomal protein L18), 유전자 등록번호(Genebank) BG186194(RPS24, Similar to ribosomal protein S24), 유전자 등록번호(Genebank) AB037719(SSH1, Slingshot homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_005415(SLC20A1, Solute carrier family 20(phosphate transporter), member 1), 유전자 등록번호(Genebank) BF680536(SAT, Spermidine/spermine N1-acetyltransferase), 유전자 등록번호(Genebank) AK127286(SMOX, Spermine oxidase), 유전자 등록번호(Genebank) NM_005877(SF3A1, Splicing factor 3a, subunit 1, 120kDa), 유전자 등록번호(Genebank) AF082557(TNKS, Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase), 유전자 등록번호(Genebank) BC002856(TXNDC11, Thioredoxin domain containing 11) 유전자 등록번호(Genebank) NM_017722(FLJ20244, TRM1 tRNA methyltransferase 1 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK023077(USP36, Ubiquitin specific peptidase 36), 유전자 등록번호(Genebank) NM_080605(B3GALT6, UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6), 유전자 등록번호(Genebank) AY358955(B3GNT3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3), 유전자 등록번호(Genebank) AK074143(UAP1L1, UDP-N-acteylglucosamine pyrophosphorylase 1-like 1), 유전자 등록번호(Genebank) C007348(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) BC047030(UPP1, Uridine phosphorylase 1), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) BU945318(MT2A, Hypothetical gene supported by X97260; BC070289), 유전자 등록번호(Genebank) BX537968(LOC51149, Hypothetical LOC51149), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) XM_371474(PLXNB2, Plexin B2), 유전자 등록번호(Genebank) BC050636(FLJ14249, HS1-binding protein 3), 유전자 등록번호(Genebank) NM_004699(FAM50A, Family with sequence similarity 50, member A), 유전자 등록번호(Genebank) AY368150(CHR2SYT, Family with sequence similarity 62(C2 domain containing) member B).
2) 상기 바이오마커 중에서, 나프탈렌의 노출에 의해 발현이 감소하는 바이오마커 유전자는 하기와 같다:
유전자 등록번호(Genebank) AF130077(ALB, Albumin), 유전자 등록번호(Genebank) NM_021631(FKSG2, Apoptosis inhibitor), 유전자 등록번호(Genebank) AF143236(C17orf88, Apoptosis related protein), 유전자 등록번호(Genebank) NM_001621(AHR, Aryl hydrocarbon receptor), 유전자 등록번호(Genebank) AB209123(BIRC1, Baculoviral IAP repeat-containing 1), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) NM_001167(BIRC4, Baculoviral IAP repeat-containing 4), 유전자 등록번호(Genebank) AW872828(BIRC6, Baculoviral IAP repeat-containing 6(apollon)), 유전자 등록번호(Genebank) AU146963(BCL2, B-cell CLL/lymphoma 2), 유전자 등록번호(Genebank) NM_004331(BNIP3L, BCL2/adenovirus E1B 19kDa interacting protein 3-like), 유전자 등록번호(Genebank) NM_001015049(BAG5, BCL2-associated athanogene 5), 유전자 등록번호(Genebank) NM_014739(BCLAF1, BCL2-associated transcription factor 1), 유전자 등록번호(Genebank) L33477(HSPD1, Cadherin 12, type 2(N-cadherin 2)), 유전자 등록번호(Genebank) NM_001904(CTNNB1, Catenin(cadherin-associated protein), beta 1, 88kDa), 유전자 등록번호(Genebank) NM_005894(CD5L, CD5 antigen-like(scavenger receptor cysteine rich family)), 유전자 등록번호(Genebank) AK124173(FLJ42179, CDNA FLJ42179 fis, clone THYMU2030796), 유전자 등록번호(Genebank) AB209095(CDC2L2, Cell division cycle 2-like 2(PITSLRE proteins)), 유전자 등록번호(Genebank) AK128462(CRR9, Cisplatin resistance related protein CRR9p), 유전자 등록번호(Genebank) NM_016424(CROP, Cisplatin resistance-associated overexpressed protein), 유전자 등록번호(Genebank) NM_003478(CUL5, Cullin 5), 유전자 등록번호(Genebank) NM_018947(CYCS, Cytochrome c, somatic), 유전자 등록번호(Genebank) BC048797(DFFB, DNA fragmentation factor, 40kDa, beta polypeptide(caspase-activated DNase)), 유전자 등록번호(Genebank) AB209361(FAS, Fas(TNF receptor superfamily, member 6)), 유전자 등록번호(Genebank) NM_006144(GZMA, Granzyme A(granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)), 유전자 등록번호(Genebank) BC013326(GAS2, Growth arrest-specific 2), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_005338(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) AK026927(MGC5297, Hypothetical protein MGC5297), 유전자 등록번호(Genebank) AB208909(ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX648731(JMY, Junction-mediating and regulatory protein), 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) NM_000314(PTEN, Phosphatase and tensin homolog(mutated in multiple advanced cancers 1)), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) BX537500(PDCD4, Programmed cell death 4(neoplastic transformation inhibitor)), 유전자 등록번호(Genebank) NM_013374(PDCD6IP, Programmed cell death 6 interacting protein), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) CR621593(PRG2, Proteoglycan 2, bone marrow(natural killer cell activator, eosinophil granule major basic protein)), 유전자 등록번호(Genebank) BC041849(ROCK1, Rho-associated, coiled-coil containing protein kinase 1), 유전자 등록번호(Genebank) NM_000582(SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)), 유전자 등록번호(Genebank) BC039110(SMNDC1, Survival motor neuron domain containing 1), 유전자 등록번호(Genebank) AB209211(TIA1, TIA1 cytotoxic granule-associated RNA binding protein), 유전자 등록번호(Genebank) AF520785(TNFSF15, Tumor necrosis factor(ligand) superfamily, member 15), 유전자 등록번호(Genebank) NM_002546(TNFRSF11B, Tumor necrosis factor receptor superfamily, member 11b(osteoprotegerin)), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) AB209534(TRA1, Tumor rejection antigen(gp96) 1), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) AB096256(UNC5B, Unc-5 homolog B(C. elegans)), 유전자 등록번호(Genebank) AF055634(UNC5C, Unc-5 homolog C(C. elegans)), 유전자 등록번호(Genebank) AK122953(VDAC1, Voltage-dependent anion channel 1), 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) BC016344(ACPP, Acid phosphatase, prostate), 유전자 등록번호(Genebank) BM921310(ANAPC10, Anaphase promoting complex subunit 10), 유전자 등록번호(Genebank) NM_153186(ANKRD15, Ankyrin repeat domain 15), 유전자 등록번호(Genebank) AY367065(ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)), 유전자 등록번호(Genebank) NM_004071(CLK1, CDC-like kinase 1), 유전자 등록번호(Genebank) CR933728(CDC2 Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_044472(CDC42, Cell division cycle 42(GTP binding protein, 25kDa)), 유전자 등록번호(Genebank) NM_004365(CETN3, Centrin, EF-hand protein, 3(CDC31 homolog, yeast)), 유전자 등록번호(Genebank) NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin)), 유전자 등록번호(Genebank) BC050310(C10orf9, Chromosome 10 open reading frame 9), 유전자 등록번호(Genebank) NM_016446(C9orf127, Chromosome 9 open reading frame 127), 유전자 등록번 호(Genebank) AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), 유전자 등록번호(Genebank) NM_001761(CCNF, Cyclin F), 유전자 등록번호(Genebank) NM_004354(CCNG2, Cyclin G2), 유전자 등록번호(Genebank) NM_004064(CDKN1B, Cyclin-dependent kinase inhibitor 1B(p27, Kip1)), 유전자 등록번호(Genebank) NM_007068(DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination(yeast)), 유전자 등록번호(Genebank) AK025142(BPA, dystonin), 유전자 등록번호(Genebank) NM_001950(E2F4, E2F transcription factor 4, p107/p130-binding), 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) AJ245671(EGFL6, EGF-like-domain, multiple 6), 유전자 등록번호(Genebank) NM_004450(ERH, Enhancer of rudimentary homolog(Drosophila)), 유전자 등록번호(Genebank) AL832041(ESCO1, Establishment of cohesion 1 homolog 1(S. cerevisiae)), 유전자 등록번호(Genebank) AL832666(ESCO2, Establishment of cohesion 1 homolog 2(S. cerevisiae)), 유전자 등록번호(Genebank) AK126048(FLJ44060, FLJ44060 protein), 유전자 등록번호(Genebank) BI494022(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) NM_014707(HDAC9, Histone deacetylase 9), 유전자 등록번호(Genebank) BC067253(FLJ40432, Hypothetical protein FLJ40432), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) BC040410(MAPRE1, Microtubule-associated protein, RP/EB family, member 1), 유전자 등록번호(Genebank) AB033337(MPHOSPH1, M-phase phosphoprotein 1), 유전자 등록번호(Genebank) L20321(NEK4, NIMA(never in mitosis gene a)-related kinase 4), 유전자 등록번호(Genebank) AJ627032(NIPBL, Nipped-B homolog(Drosophila)), 유전자 등록번호(Genebank) AL575067(NUDC, Nuclear distribution gene C homolog(A. nidulans)), 유전자 등록번호(Genebank) NM_003884(PCAF, P300/CBP-associated factor), 유전자 등록번호(Genebank) AL833922(PAPD5, PAP associated domain containing 5), 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_016205(PDGFC, Platelet derived growth factor C), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), 유전자 등록번호(Genebank) NM_006259(PRKG2, Protein kinase, cGMP-dependent, type II), 유전자 등록번호(Genebank) NM_002709(PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), 유전자 등록번호(Genebank) NM_003463(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BX647606(PTMA, Prothymosin, alpha(gene sequence 28)), 유전자 등록번호(Genebank) BC068483(RINT-1, Rad50-interacting protein 1), 유전자 등록번호(Genebank) NM_006325(RAN, RAN, member RAS oncogene family), 유전자 등록번 호(Genebank) NM_213590(RFP2, Ret finger protein 2), 유전자 등록번호(Genebank) NM_006910(RBBP6, Retinoblastoma binding protein 6), 유전자 등록번호(Genebank) BC060806(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) BX648668(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) AB208875(SEPT10, Septin 10), 유전자 등록번호(Genebank) AB209677(SEPT7, Septin 7), 유전자 등록번호(Genebank) BX649128(SESN3, Sestrin 3), 유전자 등록번호(Genebank) XM_497098(LOC441488, Similar to Transcription factor Dp-1(E2F dimerization partner 1)(DRTF1-polypeptide-1)(DRTF1)), 유전자 등록번호(Genebank) AK131071(SLC31A2, Solute carrier family 31(copper transporters), member 2), 유전자 등록번호(Genebank) NM_006930(SKP1A, S-phase kinase-associated protein 1A(p19A)), 유전자 등록번호(Genebank) NM_006542(SPHAR, S-phase response(cyclin-related)), 유전자 등록번호(Genebank) BX647885(STMN1, Stathmin 1/oncoprotein 18), 유전자 등록번호(Genebank) NM_014574(STRN3, Striatin, calmodulin binding protein 3), 유전자 등록번호(Genebank) NM_003176(SYCP1, Synaptonemal complex protein 1), 유전자 등록번호(Genebank) BM674777(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_007375(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_006701(TXNL4A, Thioredoxin-like 4A), 유전자 등록번호(Genebank) NM_030756(TCF7L2, Transcription factor 7-like 2(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) NM_000368(TSC1, Tuberous sclerosis 1), 유전자 등록번호(Genebank) NM_006826(YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide), 유전자 등록번호(Genebank) NM_001032410(USP16, Ubiquitin specific peptidase 16), 유전자 등록번호(Genebank) AK095164(KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_138271(ATRX, Alpha thalassemia/mental retardation syndrome X-linked(RAD54 homolog, S. cerevisiae)), 유전자 등록번호(Genebank) AK025738(ASF1A, ASF1 anti-silencing function 1 homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) AK125915(CRY1, Cryptochrome 1(photolyase-like)), 유전자 등록번호(Genebank) S62138(DDIT3, DNA-damage-inducible transcript 3), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) CR936783(FLJ40869, Hypothetical protein LOC284952), 유전자 등록번호(Genebank) NM_002431(MNAT1, Menage a trois 1(CAK assembly factor)), 유전자 등록번호(Genebank) BC032617(POLI, Polymerase(DNA directed) iota), 유전자 등록번호(Genebank) NM_002690(POLB, Polymerase(DNA directed), beta), 유전자 등록번호(Genebank) AK025631(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) BC038996(PMS2L1, Postmeiotic segregation increased 2-like 1), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) NM_020165(RAD18, RAD18 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) NM_152442(RAD9B, RAD9 homolog B(S. cerevisiae)), 유전자 등록번호(Genebank) NM_018151(RIF1, RAP1 interacting factor homolog(yeast)), 유전자 등록번호(Genebank) AI281523(SFPQ, Splicing factor proline/glutamine-rich(polypyrimidine tract binding protein associated)), 유전자 등록번호(Genebank) AK057830(TOM1L2, Target of myb1-like 2(chicken)), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_001071(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) AK094617(UBE2V2, Ubiquitin-conjugating enzyme E2 variant 2), 유전자 등록번호(Genebank) NM_003337(UBE2B, Ubiquitin-conjugating enzyme E2B(RAD6 homolog)), 유전자 등록번호(Genebank) CD013992(GSTT2, Glutathione S-transferase theta 2), 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) NM_000847(GSTA3, Glutathione S-transferase A3), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_017460(CYP3A4, Cytochrome P450, family 3, subfamily A, polypeptide 4), 유전자 등록번호(Genebank) BC039065(ADH6, Alcohol dehydrogenase 6(class V)), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) NM_000667(ADH1A, Alcohol dehydrogenase 1A(class I), alpha polypeptide), 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) NM_000690(ALDH2, Aldehyde dehydrogenase 2 family(mitochondrial)), 유전자 등록번호(Genebank) NM_000696(ALDH9A1, Aldehyde dehydrogenase 9 family, member A1), 유전자 등록번호(Genebank) AK093311(ACAA2, Acetyl-Coenzyme A acyltransferase 2(mitochondrial 3-oxoacyl-Coenzyme A thiolase)), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) NM_000016(ACADM, Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain), 유전자 등록번호(Genebank) BC033517(ACOX2, Acyl-Coenzyme A oxidase 2, branched chain), 유전자 등록번호(Genebank) Z28339(AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)), 유전자 등록번호(Genebank) NM_000384(APOB, Apolipoprotein B(including Ag(x) antigen)), 유전자 등록번호(Genebank) AF285167(ABCA1, ATP-binding cassette, sub-family A(ABC1), member 1), 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_003101(SOAT1, Sterol O-acyltransferase(acyl-Coenzyme A: cholesterol acyltransferase) 1), 유전자 등록번호(Genebank) T81314(MBTPS1, Transcribed locus), 유전자 등록번호(Genebank) NM_147156(TMEM23, Transmembrane protein 23), 유전자 등록번호(Genebank) NM_003916(AP1S2, Adaptor-related protein complex 1, sigma 2 subunit), 유전자 등록번호(Genebank) AA298150(AP3S1, Adaptor-related protein complex 3, sigma 1 subunit), 유전자 등록번호(Genebank) AL109702(AP3S2, Adaptor-related protein complex 3, sigma 2 subunit), 유전자 등록번호(Genebank) BU620136(AP4S1, Adaptor-related protein complex 4, sigma 1 subunit), 유전자 등록번호(Genebank) NM_001025595(ARFIP1, ADP-ribosylation factor interacting protein 1(arfaptin 1)), 유전자 등록번호(Genebank) NM_203437(AFTIPHILIN, Aftiphilin protein), 유전자 등록번호(Genebank) NM_006380(APPBP2, Amyloid beta precursor protein(cytoplasmic tail) binding protein 2), 유전자 등록번호(Genebank) BM683433(AP1GBP1, AP1 gamma subunit binding protein 1), 유전자 등록번호(Genebank) AK027773(APG4C, ATG4 autophagy related 4 homolog C(S. cerevisiae)), 유전자 등록번호(Genebank) AF130117(CRBN, Cereblon), 유전자 등록번호(Genebank) NM_001821(CHML, Choroideremia-like(Rab escort protein 2)), 유전자 등록번호(Genebank) AK002165(DKFZP564O123, Chromatin modifying protein 2B), 유전자 등록번호(Genebank) NM_152284(Shax3, Chromatin modifying protein 4C), 유전자 등록번호(Genebank) AW167080(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) BF790759(SNF7DC2, Chromatin modifying protein 5), 유전자 등록번호(Genebank) NM_018229(C14orf108, Chromosome 14 open reading frame 108), 유전자 등록번호(Genebank) AF130062(CLTC, Clathrin, heavy polypeptide(Hc)), 유전자 등록번호(Genebank) AF273058(CTAGE1, Cutaneous T-cell lymphoma-associated antigen 1), 유전자 등록번호(Genebank) AK023846(DER1, Der1-like domain family, member 1), 유전자 등록번호(Genebank) NM_145261(TIM14, DnaJ(Hsp40) homolog, subfamily C, member 19), 유전자 등록번호(Genebank) AF447177(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_004125(GNG10, DnaJ-like protein), 유전자 등록번호(Genebank) NM_015171(XPO6, Exportin 6), 유전자 등록번호(Genebank) CA306634(GTF2H3, General transcription factor IIH, polypeptide 3, 34kDa), 유전자 등록번호(Genebank) M57609(GLI3, GLI-Kruppel family member GLI3(Greig cephalopolysyndactyly syndrome)), 유전자 등록번호(Genebank) BC047660(FLJ25422, Hypothetical protein FLJ25422), 유전자 등록번호(Genebank) BC035090(KPNA3, Karyopherin alpha 3(importin alpha 4)), 유전자 등록번호(Genebank) AK093917(KDELR2, KDEL(Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2), 유전자 등록번호(Genebank) NM_173827(FLJ38991, Mitochondrial COX18), 유전자 등록번호(Genebank) NM_018698(NXT2, Nuclear transport factor 2-like export factor 2), 유전자 등록번호(Genebank) BC039468(NUP50, Nucleoporin 50kDa), 유전자 등록번호(Genebank) BC032755(PEX13, Peroxisome biogenesis factor 13), 유전자 등록번호(Genebank) AK023223(RAB10, RAB10, member RAS oncogene family), 유전자 등록번호(Genebank) AL162081(RAB14, RAB14, member RAS oncogene family), 유전자 등록번호(Genebank) AB209698(RAB18, RAB18, member RAS oncogene family), 유전자 등록번호(Genebank) NM_031296(RAB33B, RAB33B, member RAS oncogene family), 유전자 등록번호(Genebank) BC014553(RAB3IP, RAB3A interacting protein(rabin3)), 유전자 등록번호(Genebank) NM_198490(RAB43, RAB43, member RAS oncogene family), 유전자 등록번호(Genebank) NM_004162(RAB5A, RAB5A, member RAS oncogene family), 유전자 등록번호(Genebank) AL136727(RAB6C, RAB6C, member RAS oncogene family), 유전자 등록번호(Genebank) NM_016530(RAB8B, RAB8B, member RAS oncogene family), 유전자 등록번호(Genebank) NM_006267(RANBP2, RAN binding protein 2), 유전자 등록번호(Genebank) NM_020150(SARA1, SAR1 gene homolog A(S. cerevisiae)), 유전자 등록번호(Genebank) AA418814(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) AA484677(SEC22L1, SEC22 vesicle trafficking protein-like 1(S. cerevisiae)), 유전자 등록번호(Genebank) NM_031216(SEH1L, SEH1-like(S. cerevisiae)), 유전자 등록번호(Genebank) BC064351(SRP9, Signal recognition particle 9kDa), 유전자 등록번호(Genebank) NM_005843(STAM2, Signal transducing adaptor molecule(SH3 domain and ITAM motif) 2), 유전자 등록번호(Genebank) BX648363(SNX10, Sorting nexin 10), 유전자 등록번호(Genebank) AB209439(SNX15, Sorting nexin 15), 유전자 등록번호(Genebank) NM_014758(SNX19, Sorting nexin 19), 유전자 등록번호(Genebank) NM_021249(SNX6, Sorting nexin 6), 유전자 등록번호(Genebank) NM_004782(SNAP29, Synaptosomal-associated protein, 29kDa), 유전자 등록번호(Genebank) AJ420529(STX7, Syntaxin 7), 유전자 등록번호(Genebank) BC028028(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_007269(STXBP3, Syntaxin binding protein 3), 유전자 등록번호(Genebank) NM_003262(TLOC1, Translocation protein 1), 유전자 등록번호(Genebank) AK094603(FLJ37284, unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590.), 유전자 등록번호(Genebank) AL832866(VPS29, Vacuolar protein sorting 29(yeast)), 유전자 등록번호(Genebank) AK092532(FLJ10979, Vacuolar protein sorting 53(yeast)), 유전자 등록번호(Genebank) NM_015336(ZDHHC17, Zinc finger, DHHC-type containing 17), 유전자 등록번호(Genebank) AB002303(ZFYVE16, Zinc finger, FYVE domain containing 16), 유전자 등록번호(Genebank) NM_007236(CHP, Calcium binding protein P22), 유전자 등록번호(Genebank) AL137653(BARS, C-terminal binding protein 1), 유전자 등록번호(Genebank) AB017363(FZD1, Frizzled homolog 1(Drosophila)), 유전자 등록번호(Genebank) NM_017412(FZD3, Frizzled homolog 3(Drosophila)), 유전자 등록번호(Genebank) AB032417(FZD4, Frizzled homolog 4(Drosophila)), 유전자 등록번호(Genebank) AK125150(MAPK8, Mitogen-activated protein kinase 8), 유전자 등록번호(Genebank) AK025758(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_000933(PLCB4, Phospholipase C, beta 4), 유전자 등록번호(Genebank) AK131561(PRKACA, Protein kinase, cAMP-dependent, catalytic, alpha), 유전자 등 록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) BC078170(WNT2, Wingless-type MMTV integration site family member 2), 유전자 등록번호(Genebank) NM_003392(WNT5A, Wingless-type MMTV integration site family, member 5A), 유전자 등록번호(Genebank) AY009401(WNT6, Wingless-type MMTV integration site family, member 6), 유전자 등록번호(Genebank) AL832664(ANP32E, Acidic(leucine-rich) nuclear phosphoprotein 32 family, member E), 유전자 등록번호(Genebank) NM_138448(ACYP2, Acylphosphatase 2, muscle type), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) NM_175873(LOC134548, Ankyrin repeat domain 43), 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) AB013380(ABCB10, ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) M75106(CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)), 유전자 등록번호(Genebank) AK131472(FLJ16640, CDNA FLJ16640 fis, clone TESTI4028938, moderately similar to Zinc finger protein 85), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BC004543(C15orf23, Chromosome 15 open reading frame 23), 유전자 등록번호(Genebank) NM_001012507(C6orf173, Chromosome 6 open reading frame 173), 유전자 등록번호(Genebank) AK000972(C9orf40, Chromosome 9 open reading frame 40), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_018204(CKAP2, Cytoskeleton associated protein 2), 유전자 등록번호(Genebank) NM_006716(ASK, DBF4 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BC045541(LOC200895, Dihydrofolate reductase-like 1), 유전자 등록번호(Genebank) NM_152721(DOK6, Docking protein 6), 유전자 등록번호(Genebank) NM_017645(FAM29A, Family with sequence similarity 29, member A), 유전자 등록번호(Genebank) NM_207418(MGC57827, Family with sequence similarity 72, member A), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) NM_005141(FGB, Fibrinogen beta chain), 유전자 등록번호(Genebank) AB208919(FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)), 유전자 등록번호(Genebank) NM_032117(GAJ, GAJ protein), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) AB007893(KIAA0433, Histidine acid phosphatase domain containing 1), 유전자 등록번호(Genebank) AF032862(HMMR, Hyaluronan-mediated motility receptor(RHAMM)), 유전자 등록번호(Genebank) AK123495(Q5XI42, Hypothetical gene supported by AL713796), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) AL832022(FLJ13910, Hypothetical protein FLJ13910), 유전자 등록번호(Genebank) AL832208(FLJ32312, Hypothetical protein FLJ32312), 유전자 등록번호(Genebank) AB037805(KLHL14, Kelch-like 14(Drosophila)), 유전자 등록번호(Genebank) NM_014736(KIAA0101, KIAA0101), 유전자 등록번호(Genebank) AB046861(KIAA1641, KIAA1641), 유전자 등록번호(Genebank) BC033021(LOC152831, Klotho beta), 유전자 등록번호(Genebank) NM_182551(LYCAT, Lysocardiolipin acyltransferase), 유전자 등록번호(Genebank) NM_002381(MATN3, Matrilin 3), 유전자 등록번호(Genebank) AB018342(MYO10, Myosin X), 유전자 등록번호(Genebank) BX537509(NET1, Neuroepithelial cell transforming gene 1), 유전자 등록번호(Genebank) BX537360(CPSF5, Nudix(nucleoside diphosphate linked moiety X)-type motif 21), 유전자 등록번호(Genebank) NM_033222(PSIP1, PC4 and SFRS1 interacting protein 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_176869(PPA2, Pyrophosphatase(inorganic) 2), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_004586(RPS6KA3, Ribosomal protein S6 kinase, 90kDa, polypeptide 3), 유전자 등록번호(Genebank) BC064610(SEPHS1, Selenophosphate synthetase 1), 유전자 등록번호(Genebank) AK075271(SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)), 유전자 등록번호(Genebank) XM_496355(LOC440577, Similar to nucleophosmin 1), 유전자 등록번호(Genebank) XM_371758(LOC389308, Similar to ribosomal protein L10a), 유전자 등록번호(Genebank) XM_371470(LOC388907, Similar to ribosomal protein L5; 60S ribosomal protein L5), 유전자 등록번호(Genebank) XM_495961(LOC440145, Similar to RIKEN cDNA 2410129H14), 유전자 등록번호(Genebank) XM_496301(LOC440517, Similar to zinc finger protein 91(HPF7, HTF10)), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_180991(SLCO4C1, Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spc25, Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) BM458612(THRAP6, Thyroid hormone receptor associated protein 6), 유전자 등록번호(Genebank) AI300182(PROS1, Transcribed locus, weakly similar to NP_000304.1 protein S(alpha)), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AY358727(FLJ21934, UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) BC035579(ZNF100, Zinc finger protein 100), 유전자 등록번호(Genebank) AB209664(ZNF195, Zinc finger protein 195), 유전자 등록번호(Genebank) AY269786(ZNF429, Zinc finger protein 429), 유전자 등록번호(Genebank) NM_003423(ZNF43, Zinc finger protein 43(HTF6)), 유전자 등록번호(Genebank) NM_016220(ZNF588, Zinc finger protein 588), 유전자 등록번호(Genebank) AK122869(LOC148213, Zinc finger protein 681), 유전자 등록번호(Genebank) AK131527(ZNF15L1, Zinc finger protein 708(KOX8)), 유전자 등록번호(Genebank) NM_003430(ZNF91, Zinc finger protein 91(HPF7, HTF10)), 유전자 등록번 호(Genebank) NM_152626(ZNF92, Zinc finger protein 92(HTF12)).
본 발명자들은 나프탈렌에 대한 노출 여부 확인용 바이오마커를 발굴하기 위하여, 나프탈렌을 인간 간암 세포주(HepG2)에 처리하여 세포 독성을 확인하였다. 그 결과, 상기 나프탈렌은 인간 간암 세포주에 독성을 가짐이 확인되었고(도 1 참조), 상기 실험을 바탕으로 나프탈렌의 농도를 결정하였다. 이후 상기 결정된 농도로 나프탈렌을 인간 간암 세포주에 처리하고, 상기 물질을 처리한 세포주에서 mRNA를 분리하여 cDNA를 합성하면서 형광물질(Cy5)로 표지하였으며, 약물을 처리하지 않은 대조군의 경우 Cy3로 표지하였다. 상기 형광표지된 cDNA를 44 k 올리고마이크로어레이 칩 Human whole genome microarray(Agilent, USA)와 혼성화하였고, 형광 이미지를 스캔하여 유전자 발현 양상의 차이를 분석하였다(도 2 참조). 분석시 Cy5/Cy3 비율이 2.0배 이상인 경우 발현 증가된 유전자로 분류하였고, 0.5배 이하인 경우 발현 감소된 유전자로 분류하였다. 분석 결과, 발현 증가된 유전자는 0.86%(44,000개의 유전자 중 377개) 발현이 감소된 유전자는 0.71%(44,000개의 유전자 중 313개)임을 확인하였다. 이때, 나프탈렌에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 분류한 기능별로 분류하면, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경 로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction) 등의 관련 유전자들이었다(표 2 및 표 3 참조). 상기 유전자들은 본 발명에서 사용한 나프탈렌을 처리했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.
본 발명자들은 상기 유전자 중 과발현된 유전자 24종과 저발현된 유전자 21종을 분리하여 실시간 RT-PCR(real-time reverse transcript polymerase chain reaction) 방법으로 발현 양상을 조사하였다. 그 결과, 24종의 과발현 유전자들과 21종의 저발현 유전자의 발현 양상이 올리고마이크로어레이 칩 결과와 유사하게 나타남을 확인하였다(표 5 참조). 이들 유전자들은 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) BU945318(metallothionein 2A), 유전자 등록번호(Genebank) BM926478(Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) X02812(Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) BC042390(Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) NM_017572(MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) NM_173481(Chromosome 19 open reading frame 21), 유전자 등록번호(Genebank) NM_032468(Aspartate beta-hydroxylase), 유전자 등록번호(Genebank) AY247738(Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AA669162(Adenosine monophosphate deaminase(isoform E)), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) NM_003255(TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_080388(S100 calcium binding protein A16), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_001013632(polo-like kinase 3(Drosophila)), 유전자 등록번호(Genebank) BQ683841(S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769(CD9 antigen(p24)), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AF167706(Cysteine rich transmembrane BMP regulator 1(chordin-like)), 유전자 등록번호(Genebank) AB046861(KIAA1641), 유전자 등록번호(Genebank) BC068588(Similar to CG32820-PA, isoform A), 유전자 등록번호(Genebank) AY358727(UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) NM_017768(Leucine rich repeat containing 40), 유전자 등록번호(Genebank) AA074156(Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus]), 유전자 등록번호(Genebank) XM_291202(Zinc finger protein 479), 유전자 등록번호(Genebank) AB013380(ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) NM_180991(Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_145697(Cell division cycle associated 1), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BX640888(Glypican 6), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410(MAD2 mitotic arrest deficient-like 1(yeast)), 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa)이다.
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 그의 상보 가닥 분자가 집적된 나프탈렌에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.
상기 올리고 뉴클레오티드 또는 이의 상보가닥 분자는 상기 바이오마커 유전자의 18 내지 30개의 핵산을 포함하고, 바람직하게는 20 내지 25개의 핵산을 포함한다.
본 발명의 나프탈렌 검색용 DNA 마이크로어레이 칩은 당업자에게 알려진 방법으로 제작할 수 있다. 상기 마이크로어레이 칩을 제작하는 방법은 하기와 같다. 상기 탐색된 바이오마커를 탐침 DNA 분자로 이용하여 DNA 칩의 기판 상에 고정화시키기 위해 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로피펫팅(micropipetting)법 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 핀 형태의 스폿터인 마이크로어레이를 이용하였다. 상기 DNA 마이크로어레이 칩의 기판은 아미노-실란(amino-silane), 폴리-L-라이신(poly-L-lysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 하나의 활성기가 코팅된 것이 바람직하나 이에 한정되는 것은 아니다. 또한, 상기 기판은 슬라이드 글래스, 플라스틱, 금속, 실리콘, 나일론 막, 및 니트로셀룰로스 막(nitrocellulose membrane)으로 이루어진 군에서 선택될 수 있으나 이에 제한되는 것은 아니며, 본 발명의 바람직한 실시예에서는 아미노-실란이 코팅된 슬라이드 글래스를 이용하였다.
또한, 본 발명은 상기 바이오마커를 이용한 나프탈렌에 대한 노출 여부를 확 인하는 방법을 제공한다.
본 발명은 하기와 같은 과정을 포함하는 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;
2) 단계 1)의 실험군과 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질을 표지하는 단계;
3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 DNA 마이크로어레이칩과 혼성화시키는 단계;
4) 단계 3)의 반응한 DNA 마이크로어레이 칩을 분석하는 단계; 및
5) 단계 4)의 분석한 데이터에서 본 발명의 바이오마커의 발현 정도를 대조군과 비교하여 확인하는 단계,
상기 노출 여부를 확인하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다.
상기 노출 여부를 확인하는 방법에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되어지는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 형광물질은 모두 사용 가능하다.
상기 노출 여부를 확인하는 방법에 있어서, 단계 4)의 DNA 마이크로어레이 칩은 Whole Human Genome Oligo Microarray(Agilent, USA)등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간 게놈 중 본 발명에서 상기 공통적으로 과발현 또는 저발현 유전자(표 2 및 포 3 참조)가 탑재된 마이크로어레이 칩이라면 사용 가능하고, 상기 본 발명자가 제작한 DNA 마이크로어레이 칩을 사용하는 것이 가장 바람직하다. 또한, 단계 4)의 분석 방법은 GenePix 4.1 소프트웨어(Axon Instruments, USA)를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 분석 소프트웨어를 사용하여도 무방하다.
또한, 본 발명은 하기와 같은 과정을 포함하는 나프탈렌에 대한 노출 여부를 확인하는 방법을 제공한다:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;
2) 단계 1)의 RNA를, 본 발명의 바이오마커 유전자에 상보적이고 바이오마커 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및
3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계,
상기 노출 여부를 확인하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다.
상기 노출 여부를 확인하는 방법에 있어서, 단계 2)의 프라이머는 본 발명에서 탐색된 바이오마커 유전자와 상보적이고, 바이오마커를 증폭할 수 있는 프라이머라면 모두 사용가능하다. 본 발명에서는 서열번호 1 내지 90으로 기재되는 정방향 및 역방향의 프라이머 45쌍을 제시하였으나 이에 한정되는 것은 아니다.
아울러, 본 발명은 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다.
본 발명은 상기 본 발명에서 제작한 DNA 마이크로어레이 칩을 포함하는 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다.
상기 확인용 키트에 추가적으로 인간 간세포를 포함하는 나프탈렌에 대한 노출 여부 확인용 키트를 제공한다. 상기 인간 간세포는 HepG2를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포라면 모두 사용 가능하다.
상기 키트에 추가적으로 형광물질을 포함할 수 있으며, 상기 형광물질은 스트렙아비딘-알칼리 탈인화효소 접합물질(strepavidin-like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 Cy3와 Cy5를 사용하였다.
상기 키트에 추가적으로 반응 시약을 포함시킬 수 있으며, 상기 반응 시약은 혼성화에 사용되는 완충용액, RNA로부터 cDNA를 합성하기 위한 역전사효소, cNTPs 및 rNTP(사전 혼합형 또는 분리 공급형), 형광 염색제의 화학적 유도제와 같은 표 식시약, 세척 완충용액 등으로 구성될 수 있으나 이에 한정된 것은 아니며, 당업자에게 알려진 DNA 마이크로어레이 칩의 혼성화 반응에 필요한 반응 시약은 모두 포함시킬 수 있다.
상기 키트에 추가적으로 바이오마커 유전자에 상보적이고, 바이오마커 유전자를 증폭할 수 있는 프라이머를 포함시킬 수 있다. 상기 프라이머는 서열번호 1 내지 90으로 기재되는 서열로 구성된 군으로부터 선택되는 2개 이상의 정방향 및 역방향의 프라이머를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 상기 바이오마커 유전자에 상보적이며, 바이오마커 유전자를 증폭할 수 있으며 증폭산물이 100 내지 300bp가 되도록 설계된 정방향 및 역방향 프라이머쌍은 모두 사용 가능하다.
이하, 본 발명을 실시예에 의해 상세히 설명한다.
단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.
<실시예 1> 세포 배양 및 화학물질 처리
<1-1> 세포배양
인간 간암 세포주인 HepG2 세포(한국 세포주 은행)를 10% FBS가 첨가된 DMEM 배지(Gibro-BRL, USA)를 이용하여 100 ㎜ 디쉬(dish)에서 80% 정도 자랄 때까지 배 양하였다. 본 발명자들은 기존의 연구와 보고를 통해 다환방향족 탄화수소류의 하나로서 발암성을 가지고 있는 물질인 나프탈렌을 선정하였으며, DMSO에 용해시켰다. 매질(vehicle) 농도는 모든 실험에서 0.1% 이하였다.
<1-2> 세포 독성 실험( MTT assay ) 및 화학 물질 처리
Mossman 등(J. Immunol. Methods, 65, 55-63, 1983)의 방법으로 HepG2 세포주를 이용한 MTT 실험을 수행하였다. 세포는 24-웰 플레이트에 4× 105/웰 세포수로 DMEM 배지(Gibro-BRL, USA)에서 DMSO에 용해된 나프탈렌을 처리하고 48시간 후에 MTT(3-4,5-dimethylthiazol-2,5-diphenyltetra zolium bromide) 5 ㎎/㎖을 혼합하여 튜브에 가하여 37℃에서 3 시간 동안 배양하였다. 이 후 배지를 제거하고 형성된 포르마잔 크리스탈(formazan crystal)을 DMSO 500 ㎕에 용해하였다. 96-웰 플레이트로 옮겨 분주(aliquot)하고 흡광도 540 nm에서 O.D.값을 측정하였다. HepG2 세포주에서 나프탈렌의 세포독성을 살펴본 결과, 20% 생존율을 보이는 농도(IC20)는 1772.23 uM 이었으며(도 1), 상기 농도들로 결정하여 마이크로어레이 실험을 수행하였다.
< 실시예 2> 마이크로어레이 실험
<2-1> 표적 RNA 의 분리 및 형광 물질 표지
6 × 106 cell/㎖ 농도로 100 mm 디쉬에 HepG2 세포를 분주한 후, 상기 실시 예 <1-2>에서 결정된 나프탈렌의 농도를 48 시간 동안 처리하였다. 이후, 상기 처리한 세포에서 트리졸(trizol) 시약(Invitrogen life technologies, USA)을 사용하여 제조사의 방법대로 전체 RNA를 분리하고, RNeasy mini kit(Qiagen, USA)를 사용하여 정제하였다. 게놈 DNA는 RNA 정제 동안 RNase-free DNase set(Qiagen, USA)를 사용하여 제거하였다. 각 전체 RNA 시료의 양은 분광광도계로 측정하였고, 농도는 Agilent 2100 Bioanalyzer(Agilent Technologies, USA)와 아가로스 젤 전기영동으로 확인하였다.
<2-2> 표지된 cDNA 제조
올리고 마이크로어레이 분석을 위하여 상기 실시예 <2-1>에서 수득한 나프탈렌 처리군의 전체 RNA를 사용하여 cDNA를 제조하였다. 상기 수득한 전체 RNA 30 ㎍과 올리고(dT) 프라이머 2 ㎍(1 ㎍/㎕)과 혼합하고 65℃에서 10분간 반응시킨 후 바로 얼음에 넣어 어닐링(annealing)시켰다. 상기 어닐링된 RNA의 역전사(Reverse Transcript) 반응을 위해 표 1과 같이 시약을 혼합하였다.
구성 부피(㎕)
5X first strand buffer 6
dNTPs 0.6
0.1 M DDT 3
SuperScript II enzyme 3
Cy-3 or Cy-5 dUTP 2
대조군인 HepG2 세포주에서 분리한 전체 RNA는 Cy3-dUTP(녹색)로 표지화하였고, 나프탈렌을 처리한 HepG2 세포주로부터 분리한 RNA는 Cy5-dUTP(적색)로 표지화하였다. 이때 두 시료는 Microcon YM-30 컬럼(Millipore, USA)을 사용하여 혼합, 정제되었다.
<2-3> 혼성화 반응
혼성화 및 세척 과정은 지노첵(주)의 지시방법에 따라 수행되었다. 혼성화는 12시간 동안 62℃ 오븐에서 수행되었다. DNA 마이크로어레이 칩으로는 44 k Whole Human Genome Oligo Microarray(Agilent, USA)를 이용하였다. 세척(2분간 2× SSC/0.1% SDS에 세척, 3분간 1× SSC, 2분간 0.2× SSC에 세척) 후 슬라이드는 3분간 800 rpm으로 원심분리하여 건조하였다.
<2-4> 형광 이미지 획득
슬라이드 상의 혼성화 이미지는 Genepix 4000B(Axon Instruments, USA)로 스캔하였다. 결합하지 않은 유전자를 세척한 칩은 레이저 광 스캐너(laser fluorescence scanner)를 사용하여 형광 이미지를 획득하였다. 이때 녹색 형광 이미지는 대조군에서, 적색 형광 이미지는 실험군에서만 특이하게 발현되는 유전자의 활성정도를 나타내게 되며, 노란색 형광 이미지는 녹색과 적색의 보색으로 두 군의 발현이 큰 차이가 없음을 의미한다. 스캔한 이미지들은 유전자 발현 비율을 얻기 위하여 GenePix 4.1 소프트웨어(Axon Instruments, USA)로 분석하였다. 이렇게 하여 얻어진 데이터로부터 나프탈렌에 대한 마커 유전자를 선별하였다(도 2).
그 결과, 올리고 칩 상에 존재하는 대략 4만 4천 개의 유전자 중에서 나프탈렌에 의해 Cy5/Cy3의 비율이 2.0배 이상으로 유전자 발현 증가를 보이는 유전자는 0.86%(44,000개의 유전자 중 377개) 발현이 감소된 유전자는 0.71%(44,000개의 유전자 중 313개)임을 확인하였다.
이때, 나프탈렌에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 기능별로 분류한 결과, 세포 주기(cell cycle), 세포 성장(cell growth), 세포 이동(cell migration), 아팝토시스(apoptosis), 전사(transcription), 뉴클레오티드 결합(nucleotide binding), 금속원소 결합(metal binding), 자극에 대한 반응(Response to stimulus), 징크-핑거(Zinc-finger), 단백질 전달(protein transport), 면역반응(immune response), MAPKinase 신호 경로(MAPKinase signaling Pathway), WNT 신호 경로(WNT signaling pathway), 지방산 대사(fatty acid metabolism), 지질 대사(lipid metabolism), 사이토크롬에 의한 외부물질의 대사(metabolism of xenobiotics by cytochrome), 알코올 대사(Alcohol metabolism), DNA 손상 반응(response to DNA damage stimulus) 또는 갭 결합(Gap Junction)등의 관련 유전자로 선별되었다(표 2 및 3). 상기 유전자들은 본 발명에서 사용한 나프탈렌을 처리 했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.
나프탈렌에 의해 발현이 증가하는 유전자
등록번호 유전자약어 유전자명 중간값의비
(a) 아팝토시스 (Apoptosis)
BC063507 HSPA1B Heat shock 70kDa protein 1B 2.4357
NM_016639 TNFRSF12A Tumor necrosis factor receptor superfamily, member 12A 2.1347
NM_033027 AXUD1 AXIN1 up-regulated 1 2.1402
AF332558 BBC3 BCL2 binding component 3 2.1291
NM_138639 BCL2L12 BCL2-like 12 (proline rich) 2.1552
AK124526 BCAR1 Breast cancer anti-estrogen resistance 1 3.0875
NM_147780 CTSB Cathepsin B 2.3656
AB209095 CDC2L2 Cell division cycle 2-like 2 (PITSLRE proteins) 2.3134
AK128462 CRR9 Cisplatin resistance related protein CRR9p 2.0288
NM_016222 DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.0332
NM_022105 DATF1 Death inducer-obliterator 1 2.1301
AK127033 DNM2 Dynamin 2 2.4025
NM_152461 ERN1 Endoplasmic reticulum to nucleus signalling 1 2.8915
NM_003806 HRK Harakiri, BCL2 interacting protein (contains only BH3 domain) 2.4428
NM_003897 IER3 Immediate early response 3 4.6678
NM_003639 IKBKG Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.4820
BX640923 MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) 2.3952
NM_002648 PIM1 Pim-1 oncogene 2.4084
NM_003311 PHLDA2 Pleckstrin homology-like domain, family A, member 2 5.9649
NM_004309 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.2590
BC041022 SCAND1 SCAN domain containing 1 2.2502
NM_006282 STK4 Serine/threonine kinase 4 2.0747
AB005666 SIPA1 Signal-induced proliferation-associated gene 1 2.4776
NM_207111 TRIAD3 TRIAD3 protein 2.1041
AY247738 TRIB3 Tribbles homolog 3 (Drosophila) 3.6922
AF026071 TNFRSF25 Tumor necrosis factor receptor superfamily, member 25 2.8035
AB209485 VEGF Vascular endothelial growth factor 2.0271
(b) 세포 주기 (Cell Cycle)
CR606241 ACTG1 Actin, gamma 1 3.2399
NM_012127 CIZ1 CDKN1A interacting zinc finger protein 1 2.0297
AK057576 CHFR Checkpoint with forkhead and ring finger domains 2.5193
NM_005255 GAK Cyclin G associated kinase 2.3904
NM_078487 CDKN2B Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.4057
NM_001007271 DUSP13 Dual specificity phosphatase 13 2.1758
AK094316 MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 2.1290
NM_002595 PCTK2 PCTAIRE protein kinase 2 2.4224
NM_000430 PAFAH1B1 Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa 2.1603
X06374 PDGFA Platelet-derived growth factor alpha polypeptide 3.1439
NM_001722 POLR3D Polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.0189
NM_002808 PSMD2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.3245
BC038504 SNF1LK SNF1-like kinase 2.3601
BC023552 SFN Stratifin 2.6537
NM_000548 TSC2 Tuberous sclerosis 2 2.0129
AK223618 ZBTB17 Zinc finger and BTB domain containing 17 2.1258
(c) 세포 성장 (Cell Growth)
BM556279 EMP3 Epithelial membrane protein 3 3.3902
AY258066 OKL38 Pregnancy-induced growth inhibitor 2.1763
NM_001012661 SLC3A2 Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 2.2004
NM_014598 SOCS7 Suppressor of cytokine signaling 7 2.1492
(d) 세포 이동 (Cell Migration)
NM_003873 NRP1 Neuropilin 1 2.6885
NM_015366 FLJ20185 Rho GTPase activating protein 8 2.0080
AB209322 SEMA3B Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.2752
(e) 갭 결합 (Gap Junction)
AB209463 CSNK1D Casein kinase 1, delta 2.2080
NM_005228 EGFR Epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) 2.2413
BC089041 GNA11 Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 2.1930
NM_002224 ITPR3 Inositol 1,4,5-triphosphate receptor, type 3 5.6827
(f) 면역 반응 (Immune Response)
NM_012463 ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 2.4102
BQ053419 BATF Basic leucine zipper transcription factor, ATF-like 3.1080
NM_000574 DAF Decay accelerating factor for complement (CD55, Cromer blood group system) 2.0289
NM_001421 ELF4 E74-like factor 4 (ets domain transcription factor) 2.4588
BG171626 FTH1 Ferritin, heavy polypeptide 1 2.0666
BM905227 FTH1 Ferritin, heavy polypeptide 1 2.0287
NM_001015053 HDAC5 Histone deacetylase 5 2.6617
NM_003641 IFITM1 Interferon induced transmembrane protein 1 (9-27) 2.1200
AF200496 IL1F7 Interleukin 1 family, member 7 (zeta) 2.0790
NM_000641 IL11 Interleukin 11 5.2920
NM_000565 IL6R Interleukin 6 receptor 2.3392
NM_031483 ITCH Itchy homolog E3 ubiquitin protein ligase (mouse) 2.2395
NM_001300 KLF6 Kruppel-like factor 6 2.5226
AB209647 NCF2 Neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) 4.0020
NM_017670 OTUB1 OTU domain, ubiquitin aldehyde binding 1 2.0192
NM_139276 STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor) 2.0518
NM_003037 SLAMF1 Signaling lymphocytic activation molecule family member 1 2.3215
AL832287 ZAP70 Zeta-chain (TCR) associated protein kinase 70kDa 2.4777
(g) 자극에 대한 반응 (Response to Stimulus)
NM_001353 AKR1C1 Aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) 1.8820
NM_001769 CD9 CD9 antigen (p24) 2.0750
NM_005242 F2RL1 Coagulation factor II (thrombin) receptor-like 1 2.6078
AK095781 CIRBP Cold inducible RNA binding protein 2.1195
X14789 CRYAA Crystallin, alpha A 2.4242
Y11307 CYR61 Cysteine-rich, angiogenic inducer, 61 2.4270
NM_080927 DCBLD2 Discoidin, CUB and LCCL domain containing 2 2.1781
AY253982 GPR54 G protein-coupled receptor 54 2.4841
AF073799 GALR3 Galanin receptor 3 2.6980
BI767815 GP9 Glycoprotein IX (platelet) 2.1523
NM_007353 GNA12 Guanine nucleotide binding protein (G protein) alpha 12 2.1696
CR623806 HSPA6 Heat shock 70kDa protein 6 (HSP70B') 7.6428
NM_006597 HSPA8 Heat shock 70kDa protein 8 2.5025
AK000252 FLJ20245 Hypothetical protein FLJ20245 2.3061
AK057577 IRF3 Interferon regulatory factor 3 2.3088
L76191 IRAK1 Interleukin-1 receptor-associated kinase 1 2.1560
BC053882 MT1X Metallothionein 1X 2.6535
AK124709 NDRG1 N-myc downstream regulated gene 1 2.1095
NM_002658 PLAU Plasminogen activator, urokinase 2.1652
U02389 PRSS15 Protease, serine, 15 2.7031
NM_005053 RAD23A RAD23 homolog A (S. cerevisiae) 2.8373
CD357517 Unknown Similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) 2.1123
NM_032038 SPINL Spinster 2.1857
H18681 C20orf139 Sulfiredoxin 1 homolog (S. cerevisiae) 4.0214
BX648190 WDR1 WD repeat domain 1 2.6750
AK074035 XAB2 XPA binding protein 2 2.6705
(h) MAPKinase 신호 경로 (MAPKinase Signaling Pathway)
NM_004364 CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.4652
NM_017572 MKNK2 MAP kinase interacting serine/threonine kinase 2 4.3055
Z25424 MKNK2 MAP kinase interacting serine/threonine kinase 2 2.4459
AB209586 MAPK13 Mitogen-activated protein kinase 13 2.4541
NM_030662 MAP2K2 Mitogen-activated protein kinase kinase 2 2.1398
AB208849 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.2369
NM_138473 SP1 Sp1 transcription factor 2.1287
X02812 TGFB1 Transforming growth factor, beta 1 (Camurati-Engelmann disease) 5.3455
NM_002880 RAF1 V-raf-1 murine leukemia viral oncogene homolog 1 2.1696
(i) WNT 신호 경로 (WNT Signaling Pathway)
NM_152221 CSNK1E Casein kinase 1, epsilon 2.1055
AB209210 DVL1 Dishevelled, dsh homolog 1 (Drosophila) 2.8905
NM_005438 FOSL1 FOS-like antigen 1 2.3658
AF077820 LRP5 Low density lipoprotein receptor-related protein 5 2.0509
NM_033119 NKD1 Naked cuticle homolog 1 (Drosophila) 2.5071
AK090488 PPP2R1A Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 2.0154
AL834166 TCF7 Transcription factor 7 (T-cell specific, HMG-box) 2.2472
AY009401 WNT6 Wingless-type MMTV integration site family, member 6 2.1735
(j) 심장 혈관 (Cardiovascular)　
BX649164 PAI serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.5347
BM913048 TIMP1 TIMP metallopeptidase inhibitor 1 8.2651
NM_003255 TIMP2 TIMP metallopeptidase inhibitor 2 2.6909
(k) 금속 결합 (Metal-Binding)
NM_014595 NT5C 5', 3'-nucleotidase, cytosolic 2.1024
AY461712 ATP13A2 ATPase type 13A2 2.0940
NM_018590 GALNACT-2 Chondroitin sulfate GalNAcT-2 2.0202
NM_080757 C20orf127 Chromosome 20 open reading frame 127 3.0514
X16866 CYP2D7P1 Cytochrome P450, family 2, subfamily D, polypeptide 6 1.5354
NM_000782 CYP24A1 Cytochrome P450, family 24, subfamily A, polypeptide 1 2.1807
AB002454 CYP4F3 Cytochrome P450, family 4, subfamily F, polypeptide 3 1.8791
AK096809 CYP4F8 Cytochrome P450, family 4, subfamily F, polypeptide 8 1.8150
NM_000786 CYP51A1 Cytochrome P450, family 51, subfamily A, polypeptide 1 2.0107
NM_017556 FBLP-1 Filamin binding LIM protein 1 2.7416
AK093560 INPP1 Inositol polyphosphate-1-phosphatase 2.8551
NM_005578 LPP LIM domain containing preferred translocation partner in lipoma 2.4354
AK222601 MMP10 Matrix metallopeptidase 10 (stromelysin 2) 4.5500
NM_005947 MT1B Metallothionein 1B (functional) 2.4288
BC048334 MT1G Metallothionein 1G 2.3492
BI488702 MT1K Metallothionein 1M 2.6949
NM_182924 MICAL-L2 MICAL-like 2 2.1021
AK127759 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) 2.1660
NM_203353 PDLIM7 PDZ and LIM domain 7 (enigma) 2.5393
NM_002627 PFKP Phosphofructokinase, platelet 2.2877
AA862994 S100A3 S100 calcium binding protein A3 2.5978
NM_003461 ZYX Zyxin 2.8111
(l) 뉴클레오티드 결합 (Nucleotide Binding)
NM_019112 ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.3438
AB209054 ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 2.0426
U49248 ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.2186
NM_020038 ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.1296
BC025358 ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.1904
NM_003992 CLK3 CDC-like kinase 3 2.1613
AK128154 C9orf86 Chromosome 9 open reading frame 86 2.0641
BC006404 SKD3 ClpB caseinolytic peptidase B homolog (E. coli) 2.1818
BC067254 COASY Coenzyme A synthase 2.0712
NM_004398 DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.0691
BC038417 DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 2.2837
NM_138614 DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 2.2717
NM_032656 DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 2.1592
NM_020812 DOCK6 Dedicator of cytokinesis 6 2.1031
NM_004431 EPHA2 EPH receptor A2 2.5182
NM_001961 EEF2 Eukaryotic translation elongation factor 2 2.5914
NM_003751 EIF3S9 Eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa 2.2418
AF114818 SIAHBP1 Fuse-binding protein-interacting repressor 2.3625
NM_019096 GTPBP2 GTP binding protein 2 2.1428
NM_006572 GNA13 Guanine nucleotide binding protein (G protein), alpha 13 2.3739
AK128226 HK1 Hexokinase 1 3.5070
BC069201 FLJ22761 Hexokinase domain containing 1 3.2441
NM_006546 IMP-1 IGF-II mRNA-binding protein 1 3.8699
NM_015155 KIAA0217 La ribonucleoprotein domain family, member 5 2.1035
NM_018357 FLJ11196 La ribonucleoprotein domain family, member 6 4.6953
AK127089 MTHFD1L Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 2.2572
XM_038150 MAST3 Microtubule associated serine/threonine kinase 3 2.2030
AB058686 MYO15B Myosin XVB pseudogene 2.7025
BC027875 MYO15B Myosin XVB pseudogene 2.1437
AK122664 NRBP Nuclear receptor binding protein 2.1497
NM_001001852 PIM3 Pim-3 oncogene 2.8912
BC094766 PKN1 Protein kinase N1 2.2451
AK094474 RHOC Ras homolog gene family, member C 2.2466
NM_019034 RHOF Ras homolog gene family, member F (in filopodia) 2.0637
NM_016084 RASD1 RAS, dexamethasone-induced 1 2.0911
AY369207 RBPMS2 RNA binding protein with multiple splicing 2 2.1833
BC069233 SCYL1 SCY1-like 1 (S. cerevisiae) 2.0042
AB209553 STK11 Serine/threonine kinase 11 2.1115
AK124047 C20orf119 Similar to embryonic poly(A) binding protein 2.5798
XM_496374 LOC440595 Similar to eukaryotic translation elongation factor 1 alpha 1 3.7535
NM_005094 SLC27A4 Solute carrier family 27 (fatty acid transporter), member 4 2.2003
NM_003330 TXNRD1 Thioredoxin reductase 1 3.7431
NM_025195 TRIB1 Tribbles homolog 1 (Drosophila) 2.4698
BC009900 UBE1 Ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature sensitivity complementing) 2.0178
AF045458 ULK1 Unc-51-like kinase 1 (C. elegans) 2.1305
X59303 VARS2 Valyl-tRNA synthetase 2.8905
(m) 단백질 전달 (Protein Transport)
AB209808 AP1M1 Adaptor-related protein complex 1, mu 1 subunit 2.2744
AB208804 AP3D1 Adaptor-related protein complex 3, delta 1 subunit 2.4371
BC000786 ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.1516
AK125277 APG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 2.0954
NM_007097 CLTB Clathrin, light polypeptide (Lcb) 2.3501
AK091056 COBRA1 Cofactor of BRCA1 2.2297
AF349676 COG3 Component of oligomeric golgi complex 3 2.5958
AB002368 XPO6 Exportin 6 2.0361
BX648781 GABARAPL1 GABA(A) receptor-associated protein like 1 2.0637
AK123405 GDI1 GDP dissociation inhibitor 1 2.2754
NM_004712 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 2.5054
AK094897 IPO4 Importin 4 2.2353
L38951 KPNB1 Karyopherin (importin) beta 1 2.5530
NM_002268 KPNA4 Karyopherin alpha 4 (importin alpha 3) 2.4114
AY014403 KIF13A Kinesin family member 13A 2.4062
NM_002867 RAB3B RAB3B, member RAS oncogene family 3.7251
AK025300 RANBP3 RAN binding protein 3 2.2109
AB014551 ARHGEF2 Rho/rac guanine nucleotide exchange factor (GEF) 2 2.3320
CD049342 RPL23 Ribosomal protein L23 2.5856
NM_005843 STAM2 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 2.1286
NM_006809 TOMM34 Translocase of outer mitochondrial membrane 34 2.1012
BC047528 TOMM40 Translocase of outer mitochondrial membrane 40 homolog (yeast) 2.1681
AK056701 VPS11 Vacuolar protein sorting 11 (yeast) 2.0597
BC042390 VTI1B Vesicle transport through interaction with t-SNAREs homolog 1B (yeast) 4.4705
(n) 전사 (Transcription)
AK095154 AES Amino-terminal enhancer of split 2.4747
BC060828 ARID3A AT rich interactive domain 3A (BRIGHT- like) 2.3563
NM_003670 BHLHB2 Basic helix-loop-helix domain containing, class B, 2 2.7959
NM_006442 DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.6142
NM_006532 ELL Elongation factor RNA polymerase II 2.0523
NM_001991 EZH1 Enhancer of zeste homolog 1 (Drosophila) 2.0169
U18018 ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF) 2.4208
NM_002018 FLII Flightless I homolog (Drosophila) 2.2216
NM_181430 FOXK2 Forkhead box K2 2.1459
NM_001012426 FOXP4 Forkhead box P4 2.0507
BC053850 FOXQ1 Forkhead box Q1 2.0124
AF176422 HEY1 Hairy/enhancer-of-split related with YRPW motif 1 3.0373
BC078664 HMGA1 High mobility group AT-hook 1 5.3814
XM_379934 KIAA1718 KIAA1718 protein 2.6486
BC069156 LBX1 Ladybird homeobox homolog 1 (Drosophila) 2.2588
NM_014520 MYBBP1A MYB binding protein (P160) 1a 2.2230
NM_002518 NPAS2 Neuronal PAS domain protein 2 2.5247
NM_001001716 NFKBIB Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.0983
AF087856 NCOR1 Nuclear receptor co-repressor 1 2.2704
NM_002653 PITX1 Paired-like homeodomain transcription factor 1 2.9461
NM_001003891 PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein 2.3417
NM_005035 POLRMT Polymerase (RNA) mitochondrial (DNA directed) 2.4502
NM_012448 STAT5B Signal transducer and activator of transcription 5B 2.0749
CR607342 RNPS1 Similar to splicing-related factor RNPS1 2.7373
NM_005986 SOX1 SRY (sex determining region Y)-box 1 2.2649
NM_003072 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.3172
NM_006951 TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 2.7705
NM_152380 TBX15 T-box 15 2.0407
NM_016569 TBX3 T-box 3 (ulnar mammary syndrome) 2.5060
BC006396 TLX2 T-cell leukemia, homeobox 2 2.5301
AF106934 THRAP5 Thyroid hormone receptor associated protein 5 2.0678
AF108461 UBN1 Ubinuclein 1 2.5683
NM_002359 MAFG V-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 2.4125
AK092414 MAFK V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 2.9903
(o) 징크-핑거 (Zinc-Finger)
AK128553 ZZANK1 Mindbomb homolog 2 (Drosophila) 2.3102
NM_001003694 BRPF1 Bromodomain and PHD finger containing, 1 2.0045
CR936799 FHL2 Four and a half LIM domains 2 2.7892
NM_139201 GIT2 G protein-coupled receptor kinase interactor 2 2.9299
AK125974 p66alpha GATA zinc finger domain containing 2A 2.0077
CB050471 GLI4 GLI-Kruppel family member GLI4 2.4802
NM_006734 HIVEP2 Human immunodeficiency virus type I enhancer binding protein 2 2.7432
NM_031297 DKFZP761H1710 Hypothetical protein DKFZp761H1710 2.0282
NM_024671 FLJ23436 Hypothetical protein FLJ23436 2.7168
NM_173680 MGC33584 Hypothetical protein MGC33584 2.3686
NM_031918 KLF16 Kruppel-like factor 16 2.2288
BU163740 MKRN1 Makorin, ring finger protein, 1 2.2720
NM_005885 MARCH-VI Membrane-associated ring finger (C3HC4) 6 2.1710
AF242768 LOC51333 Mesenchymal stem cell protein DSC43 2.1850
NM_020774 MIB1 Mindbomb homolog 1 (Drosophila) 3.2826
AJ007041 MLL4 Myeloid/lymphoid or mixed-lineage leukemia 4 2.6133
BF206103 ZNF286 Peroxisome proliferative activated receptor, alpha-like 2.1100
BC008834 PHF1 PHD finger protein 1 2.2745
D87076 PHF15 PHD finger protein 15 2.3260
NM_020122 KCMF1 Potassium channel modulatory factor 1 2.2368
NM_145214 TRIM11 Tripartite motif-containing 11 2.4353
NM_033452 TRIM47 Tripartite motif-containing 47 2.1489
AF281046 TRIM8 Tripartite motif-containing 8 2.1328
BC004256 ZNF259 Zinc finger protein 259 2.1638
CR597101 ZFP36 Zinc finger protein 36, C3H type, homolog (mouse) 2.0256
NM_198055 ZNF42 Zinc finger protein 42 (myeloid-specific retinoic acid-responsive) 2.4424
BC071620 ZNF581 Zinc finger protein 581 2.9613
BM544755 ZNF593 Zinc finger protein 593 2.2741
AK024487 ZNF598 Zinc finger protein 598 2.4525
BC089449 ZEC Zinc finger protein 628 3.2540
NM_153813 ZFPM1 Zinc finger protein, multitype 1 2.8352
BM451410 ZA20D2 Zinc finger, A20 domain containing 2 2.7639
BX648551 ZA20D2 Zinc finger, A20 domain containing 2 2.3342
BC006340 ZCCHC2 Zinc finger, CCHC domain containing 2 2.1475
BC053544 ZDHHC8 Zinc finger, DHHC-type containing 8 3.2750
(p) 대사 (Metabolism)
NM_000499 CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 1.6642
BQ939577 AKR1C3 Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) 1.7959
BC020744 AKR1C4 Aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) 1.9104
AB045292 TMEM8 Transmembrane protein 8 (five membrane-spanning domains) 2.7291
NM_012088 PGLS 6-phosphogluconolactonase 2.0756
NM_184041 ALDOA Aldolase A, fructose-bisphosphate 2.8600
NM_000402 G6PD Glucose-6-phosphate dehydrogenase 2.5537
NM_006715 MAN2C1 Mannosidase, alpha, class 2C, member 1 2.1585
CR597860 C19orf27 Chromosome 19 open reading frame 27 2.0738
AK091948 LTB4DH Leukotriene B4 12-hydroxydehydrogenase 2.1620
BC042195 MT Malonyl-CoA:acyl carrier protein transacylase, mitochondrial 2.5698
BC035124 UNQ2541 MSFL2541 2.0030
AK057049 PTGES2 Prostaglandin E synthase 2 2.2937
AB046825 GBA2 Glucosidase, beta (bile acid) 2 2.1836
BC033110 HSD17B1 Hydroxysteroid (17-beta) dehydrogenase 1 2.2021
BC050553 NTE Neuropathy target esterase 2.0635
NM_007169 PEMT Phosphatidylethanolamine N-methyltransferase 2.3922
NM_005028 PIP5K2A Phosphatidylinositol-4-phosphate 5-kinase, type II, alpha 2.1013
BC007612 PSAP Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) 2.2731
BC087612 SBF1 SET binding factor 1 2.7731
BQ683841 S100A11 S100 calcium binding protein A11 (calgizzarin) 2.4391
CK000930 HIST1H2AI Histone 1, H2ai 2.1816
NM_003516 HIST2H2AA Histone 2, H2aa 2.7899
BC069193 HIST2H2BE Histone 2, H2be 2.1012
AK223291 MMP3 Matrix metallopeptidase 3 (stromelysin 1, progelatinase) 17.8294
NM_178819 DKFZp586M1819 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) 2.0691
NM_018694 ARL6IP4 ADP-ribosylation-like factor 6 interacting protein 4 2.0069
BC014895 MGC10204 Aldehyde dehydrogenase 16 family, member A1 2.0489
NM_032468 ASPH Aspartate beta-hydroxylase 3.9487
BC008751 CAPN1 Calpain 1, (mu/I) large subunit 2.2634
AK128552 CAPN10 Calpain 10 2.1500
AK124751 CAPN2 Calpain 2, (m/II) large subunit 2.8972
NM_001903 CTNNA1 Catenin (cadherin-associated protein), alpha 1, 102kDa 2.1134
BC067289 CTSL2 Cathepsin L2 2.1645
NM_015151 C21orf106 Chromosome 21 open reading frame 106 2.3953
NM_031434 C7orf21 Chromosome 7 open reading frame 21 2.7044
NM_001303 COX10 COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) 2.1768
BP317375 COX6A2 Cytochrome c oxidase subunit VIa polypeptide 2 2.0748
NM_001355 DDT D-dopachrome tautomerase 2.1380
NM_032482 DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 3.0258
NM_004419 DUSP5 Dual specificity phosphatase 5 4.2893
AB210013 EIF4G1 Eukaryotic translation initiation factor 4 gamma, 1 2.1430
NM_020158 EXOSC5 Exosome component 5 2.4434
NM_178225 FBXW5 F-box and WD-40 domain protein 5 2.4381
NM_058229 FBXO32 F-box protein 32 2.5325
AB209592 GMPPA GDP-mannose pyrophosphorylase A 2.0382
AJ002231 GNPDA1 Glucosamine-6-phosphate deaminase 1 2.0840
AK094940 GCLC Glutamate-cysteine ligase, catalytic subunit 2.0800
NM_005318 H1F0 H1 histone family, member 0 2.2238
NM_004639 BAT3 HLA-B associated transcript 3 2.0966
NM_032717 MGC11324 Hypothetical protein MGC11324 3.1893
BX647357 IDS Iduronate 2-sulfatase (Hunter syndrome) 2.2961
AY923172 KLK13 Kallikrein 13 2.0529
AK023137 MGAT4B Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.1114
NM_024864 FLJ22578 Mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.0371
NM_153006 NAGS N-acetylglutamate synthase 2.4751
NM_020230 PPAN Peter pan homolog (Drosophila) 2.2372
BC017045 PYGB Phosphorylase, glycogen; brain 2.1455
NM_005401 PTPN14 Protein tyrosine phosphatase, non-receptor type 14 2.9347
AF290614 PTPN23 Protein tyrosine phosphatase, non-receptor type 23 2.2544
BX648253 PTPN3 Protein tyrosine phosphatase, non-receptor type 3 2.1766
NM_002840 PTPRF Protein tyrosine phosphatase, receptor type, F 2.1548
D15049 PTPRH Protein tyrosine phosphatase, receptor type, H 2.4000
AF348492 RBAF600 Retinoblastoma-associated factor 600 2.0158
BM926478 RBP1 Retinol binding protein 1, cellular 5.9460
AB209196 RNH Ribonuclease/angiogenin inhibitor 1 2.3179
CR619918 RPL18A Ribosomal protein L18a 2.0237
BM553074 RPS15A Ribosomal protein S15a 2.1388
CD387408 RPS28 Ribosomal protein S28 2.1116
CR749837 RPS7 Ribosomal protein S7 3.8230
BM805682 EEF1D Similar to eukaryotic translation elongation factor 1 delta isoform 1; guanine nucleotide exchange protein 2.0044
XM_069734 LOC136143 Similar to ribosomal protein L18; 60S ribosomal protein L18 2.1716
BG186194 RPS24 Similar to ribosomal protein S24 2.1725
AB037719 SSH1 Slingshot homolog 1 (Drosophila) 2.0236
NM_005415 SLC20A1 Solute carrier family 20 (phosphate transporter), member 1 2.6617
BF680536 SAT Spermidine/spermine N1-acetyltransferase 2.0666
AK127286 SMOX Spermine oxidase 2.2385
NM_005877 SF3A1 Splicing factor 3a, subunit 1, 120kDa 2.5405
AF082557 TNKS Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.2491
BC002856 TXNDC11 Thioredoxin domain containing 11 2.0276
NM_017722 FLJ20244 TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae) 2.2575
AK023077 USP36 Ubiquitin specific peptidase 36 2.0848
NM_080605 B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 2.3174
AY358955 B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 2.9013
AK074143 UAP1L1 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 2.2174
BC007348 UPP1 Uridine phosphorylase 1 3.2254
BC047030 UPP1 Uridine phosphorylase 1 4.2413
(q) 기타(TheOthers)
AK095363 AQP3 Aquaporin 3 2.9486
NM_022153 PP2135 Chromosome 10 open reading frame 54 2.6192
NM_004864 GDF15 Growth differentiation factor 15 4.7569
BU945318 MT2A Hypothetical gene supported by X97260; BC070289 5.2013
BX537968 LOC51149 Hypothetical LOC51149 4.0784
NM_080388 S100A16 S100 calcium binding protein A16 2.6299
NM_001013632 LOC343521 Similar to hypothetical protein 4833401D15 2.5106
XM_371474 PLXNB2 Plexin B2 2.0885
BC050636 FLJ14249 HS1-binding protein 3 2.3649
NM_004699 FAM50A Family with sequence similarity 50, member A 2.1704
AY368150 CHR2SYT Family with sequence similarity 62 (C2 domain containing) member B 2.1260
나프탈렌에 의해 발현이 감소하는 유전자
등록번호 유전자약어 유전자명 중간값의비
(a) 아팝토시스 (Apoptosis)
AF130077 ALB Albumin 0.2470
NM_021631 FKSG2 Apoptosis inhibitor 0.4863
AF143236 C17orf88 Apoptosis related protein 0.4860
NM_001621 AHR Aryl hydrocarbon receptor 0.4324
AB209123 BIRC1 Baculoviral IAP repeat-containing 1 0.4711
NM_001165 BIRC3 Baculoviral IAP repeat-containing 3 0.3259
NM_001167 BIRC4 Baculoviral IAP repeat-containing 4 0.3782
AW872828 BIRC6 Baculoviral IAP repeat-containing 6 (apollon) 0.3599
AU146963 BCL2 B-cell CLL/lymphoma 2 0.3712
NM_004331 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.4869
NM_001015049 BAG5 BCL2-associated athanogene 5 0.2893
NM_014739 BCLAF1 BCL2-associated transcription factor 1 0.3343
L33477 HSPD1 Cadherin 12, type 2 (N-cadherin 2) 0.3494
NM_001904 CTNNB1 Catenin (cadherin-associated protein), beta 1, 88kDa 0.4256
NM_005894 CD5L CD5 antigen-like (scavenger receptor cysteine rich family) 0.4761
AK124173 FLJ42179 CDNA FLJ42179 fis, clone THYMU2030796 0.3375
AB209095 CDC2L2 Cell division cycle 2-like 2 (PITSLRE proteins) 0.3329
AK128462 CRR9 Cisplatin resistance related protein CRR9p 0.4465
NM_016424 CROP Cisplatin resistance-associated overexpressed protein 0.4535
NM_003478 CUL5 Cullin 5 0.4738
NM_018947 CYCS Cytochrome c, somatic 0.3804
BC048797 DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 0.4218
AB209361 FAS Fas (TNF receptor superfamily, member 6) 0.4189
NM_006144 GZMA Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.2852
BC013326 GAS2 Growth arrest-specific 2 0.1826
AK122825 HMGB1 High-mobility group box 1 0.4168
NM_005338 HIP1 Huntingtin interacting protein 1 0.4582
AK026927 MGC5297 Hypothetical protein MGC5297 0.4848
AB208909 ITGB2 Integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1; macrophage antigen 1 (mac-1) beta subunit) 0.4052
AF208043 IFI16 Interferon, gamma-inducible protein 16 0.2579
BX648731 JMY Junction-mediating and regulatory protein 0.4546
AK122614 PPARD Peroxisome proliferative activated receptor, delta 0.3613
NM_000314 PTEN Phosphatase and tensin homolog (mutated in multiple advanced cancers 1) 0.3736
BC047362 PHLDA1 Pleckstrin homology-like domain, family A, member 1 0.4627
BX537500 PDCD4 Programmed cell death 4 (neoplastic transformation inhibitor) 0.4064
NM_013374 PDCD6IP Programmed cell death 6 interacting protein 0.3143
NM_005400 PRKCE Protein kinase C, epsilon 0.4773
CR621593 PRG2 Proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.4124
BC041849 ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.4088
NM_000582 SPP1 Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) 0.4494
BC039110 SMNDC1 Survival motor neuron domain containing 1 0.3637
AB209211 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.4163
AF520785 TNFSF15 Tumor necrosis factor (ligand) superfamily, member 15 0.4626
NM_002546 TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) 0.4829
NM_148957 TNFRSF19 Tumor necrosis factor receptor superfamily, member 19 0.4213
NM_006290 TNFAIP3 Tumor necrosis factor, alpha-induced protein 3 0.4765
AK125880 TP53INP1 Tumor protein p53 inducible nuclear protein 1 0.2437
AB209534 TRA1 Tumor rejection antigen (gp96) 1 0.3700
NM_012479 YWHAG Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.4668
AB096256 UNC5B Unc-5 homolog B (C. elegans) 0.3575
AF055634 UNC5C Unc-5 homolog C (C. elegans) 0.2450
AK122953 VDAC1 Voltage-dependent anion channel 1 0.3437
(b) 세포 주기 (Cell Cycle)
NM_019001 XRN1 5'-3' exoribonuclease 1 0.4600
BC016344 ACPP Acid phosphatase, prostate 0.2091
BM921310 ANAPC10 Anaphase promoting complex subunit 10 0.2038
NM_153186 ANKRD15 Ankyrin repeat domain 15 0.4849
AY367065 ASPM Asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.4239
NM_004071 CLK1 CDC-like kinase 1 0.4302
CR933728 CDC2 Cell division cycle 2, G1 to S and G2 to M 0.3888
NM_044472 CDC42 Cell division cycle 42 (GTP binding protein, 25kDa) 0.3824
NM_004365 CETN3 Centrin, EF-hand protein, 3 (CDC31 homolog, yeast) 0.3285
NM_016343 CENPF Centromere protein F, 350/400ka (mitosin) 0.4456
BC050310 C10orf9 Chromosome 10 open reading frame 9 0.4646
NM_016446 C9orf127 Chromosome 9 open reading frame 127 0.4651
AY257469 CIT Citron (rho-interacting, serine/threonine kinase 21) 0.3644
NM_001761 CCNF Cyclin F 0.2478
NM_004354 CCNG2 Cyclin G2 0.2704
NM_004064 CDKN1B Cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.2642
NM_007068 DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.4227
AK025142 BPA dystonin 0.3491
NM_001950 E2F4 E2F transcription factor 4, p107/p130-binding 0.4681
NM_019063 EML4 Echinoderm microtubule associated protein like 4 0.4562
AJ245671 EGFL6 EGF-like-domain, multiple 6 0.4019
NM_004450 ERH Enhancer of rudimentary homolog (Drosophila) 0.4927
AL832041 ESCO1 Establishment of cohesion 1 homolog 1 (S. cerevisiae) 0.4949
AL832666 ESCO2 Establishment of cohesion 1 homolog 2 (S. cerevisiae) 0.4188
AK126048 FLJ44060 FLJ44060 protein 0.4358
BI494022 GRLF1 Glucocorticoid receptor DNA binding factor 1 0.4778
NM_000189 HK2 Hexokinase 2 0.4716
NM_014707 HDAC9 Histone deacetylase 9 0.4727
BC067253 FLJ40432 Hypothetical protein FLJ40432 0.4450
AL834276 MGC3207 Hypothetical protein MGC3207 0.2939
NM_006101 KNTC2 Kinetochore associated 2 0.3694
NM_014751 MTSS1 Metastasis suppressor 1 0.3809
BC040410 MAPRE1 Microtubule-associated protein, RP/EB family, member 1 0.3533
AB033337 MPHOSPH1 M-phase phosphoprotein 1 0.4700
L20321 NEK4 NIMA (never in mitosis gene a)-related kinase 4 0.3915
AJ627032 NIPBL Nipped-B homolog (Drosophila) 0.3828
AL575067 NUDC Nuclear distribution gene C homolog (A. nidulans) 0.2686
NM_003884 PCAF P300/CBP-associated factor 0.4576
AL833922 PAPD5 PAP associated domain containing 5 0.2823
NM_018492 PBK PDZ binding kinase 0.4655
NM_016205 PDGFC Platelet derived growth factor C 0.3932
NM_000430 PAFAH1B1 Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa 0.4222
NM_006259 PRKG2 Protein kinase, cGMP-dependent, type II 0.1950
NM_002709 PPP1CB Protein phosphatase 1, catalytic subunit, beta isoform 0.4052
NM_003463 PTP4A1 Protein tyrosine phosphatase type IVA, member 1 0.3644
BX647606 PTMA Prothymosin, alpha (gene sequence 28) 0.2509
BC068483 RINT-1 Rad50-interacting protein 1 0.2983
NM_006325 RAN RAN, member RAS oncogene family 0.2802
NM_213590 RFP2 Ret finger protein 2 0.4913
NM_006910 RBBP6 Retinoblastoma binding protein 6 0.4444
BC060806 RECK Reversion-inducing-cysteine-rich protein with kazal motifs 0.4205
BX648668 RECK Reversion-inducing-cysteine-rich protein with kazal motifs 0.2887
AB208875 SEPTIN10 Septin 10 0.2853
AB209677 SEPTIN7 Septin 7 0.4812
BX649128 SESN3 Sestrin 3 0.2184
XM_497098 LOC441488 Similar to Transcription factor Dp-1 (E2F dimerization partner 1) (DRTF1-polypeptide-1) (DRTF1) 0.3507
AK131071 SLC31A2 Solute carrier family 31 (copper transporters), member 2 0.4756
NM_006930 SKP1A S-phase kinase-associated protein 1A (p19A) 0.4155
NM_006542 SPHAR S-phase response (cyclin-related) 0.3856
BX647885 STMN1 Stathmin 1/oncoprotein 18 0.4937
NM_014574 STRN3 Striatin, calmodulin binding protein 3 0.2821
NM_003176 SYCP1 Synaptonemal complex protein 1 0.4556
BM674777 TARDBP TAR DNA binding protein 0.3287
NM_007375 TARDBP TAR DNA binding protein 0.3780
NM_006701 TXNL4A Thioredoxin-like 4A 0.4847
NM_030756 TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG-box) 0.1645
NM_003318 TTK TTK protein kinase 0.4857
NM_000368 TSC1 Tuberous sclerosis 1 0.4235
NM_006826 YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.2534
NM_001032410 USP16 Ubiquitin specific peptidase 16 0.4931
AK095164 KRAS2 V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.4194
(c) DNA 손상에 대한 반응 (Response to DNA Damage Stimulus)
NM_138271 ATRX Alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) 0.3074
AK025738 ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae) 0.2657
AK074377 UHRF1 Chromosome 19 open reading frame 31 0.3053
AK125915 CRY1 Cryptochrome 1 (photolyase-like) 0.4796
S62138 DDIT3 DNA-damage-inducible transcript 3 0.4310
DQ140356 KIAA1596 Fanconi anemia, complementation group M 0.2500
CR600021 HMGB2 High-mobility group box 2 0.3350
CR936783 FLJ40869 Hypothetical protein LOC284952 0.3425
NM_002431 MNAT1 Menage a trois 1 (CAK assembly factor) 0.4085
BC032617 POLI Polymerase (DNA directed) iota 0.2253
NM_002690 POLB Polymerase (DNA directed), beta 0.3335
AK025631 POLH Polymerase (DNA directed), eta 0.4675
BC038996 PMS2L1 Postmeiotic segregation increased 2-like 1 0.3834
BM462208 PCNA Proliferating cell nuclear antigen 0.2993
NM_020165 RAD18 RAD18 homolog (S. cerevisiae) 0.4502
NM_152442 RAD9B RAD9 homolog B (S. cerevisiae) 0.3773
NM_018151 RIF1 RAP1 interacting factor homolog (yeast) 0.2385
AI281523 SFPQ Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) 0.4114
AK057830 TOM1L2 Target of myb1-like 2 (chicken) 0.2985
NM_001012716 TYMS Thymidylate synthetase 0.4997
NM_001071 TYMS Thymidylate synthetase 0.4794
NM_003368 USP1 Ubiquitin specific peptidase 1 0.4284
AK094617 UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 0.4544
NM_003337 UBE2B Ubiquitin-conjugating enzyme E2B (RAD6 homolog) 0.4379
(d) 대사 (Metabolism)
CD013992 GSTT2 Glutathione S-transferase theta 2 0.4194
J05428 UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.2638
NM_000847 GSTA3 Glutathione S-transferase A3 0.4806
M15943 ADH4 Alcohol dehydrogenase 4 (class II), pi polypeptide 0.4973
NM_017460 CYP3A4 Cytochrome P450, family 3, subfamily A, polypeptide 4 0.3676
BC039065 ADH6 Alcohol dehydrogenase 6 (class V) 0.4063
NM_000671 ADH5 Alcohol dehydrogenase 5 (class III), chi polypeptide 0.4334
NM_000667 ADH1A Alcohol dehydrogenase 1A (class I), alpha polypeptide 0.4657
BI762502 GSTA2 Glutathione S-transferase A2 0.3989
NM_000690 ALDH2 Aldehyde dehydrogenase 2 family (mitochondrial) 0.2932
NM_000696 ALDH9A1 Aldehyde dehydrogenase 9 family, member A1 0.4254
AK093311 ACAA2 Acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 0.2830
NM_004457 ACSL3 Acyl-CoA synthetase long-chain family member 3 0.2528
NM_000016 ACADM Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.2904
BC033517 ACOX2 Acyl-Coenzyme A oxidase 2, branched chain 0.3508
Z28339 AKR1D1 Aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) 0.3142
NM_000384 APOB Apolipoprotein B (including Ag(x) antigen) 0.3541
AF285167 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.3587
NM_000236 LIPC Lipase, hepatic 0.3989
AK124635 PCSK9 Proprotein convertase subtilisin/kexin type 9 0.3387
NM_003101 SOAT1 Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 0.3811
T81314 MBTPS1 Transcribed locus 0.4962
NM_147156 TMEM23 Transmembrane protein 23 0.4514
(e) 단백질 전달 (Protein Transport)　
NM_003916 AP1S2 Adaptor-related protein complex 1, sigma 2 subunit 0.3059
AA298150 AP3S1 Adaptor-related protein complex 3, sigma 1 subunit 0.3585
AL109702 AP3S2 Adaptor-related protein complex 3, sigma 2 subunit 0.4502
BU620136 AP4S1 Adaptor-related protein complex 4, sigma 1 subunit 0.2439
NM_001025595 ARFIP1 ADP-ribosylation factor interacting protein 1 (arfaptin 1) 0.3191
NM_203437 AFTIPHILIN Aftiphilin protein 0.4755
NM_006380 APPBP2 Amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.3886
BM683433 AP1GBP1 AP1 gamma subunit binding protein 1 0.3501
AK027773 APG4C ATG4 autophagy related 4 homolog C (S. cerevisiae) 0.4213
AF130117 CRBN Cereblon 0.3682
NM_001821 CHML Choroideremia-like (Rab escort protein 2) 0.4712
AK002165 DKFZP564O123 Chromatin modifying protein 2B 0.4386
NM_152284 Shax3 Chromatin modifying protein 4C 0.3795
AW167080 SNF7DC2 Chromatin modifying protein 5 0.3159
BF790759 SNF7DC2 Chromatin modifying protein 5 0.4922
NM_018229 C14orf108 Chromosome 14 open reading frame 108 0.4247
AF130062 CLTC Clathrin, heavy polypeptide (Hc) 0.2665
AF273058 CTAGE1 Cutaneous T-cell lymphoma-associated antigen 1 0.3957
AK023846 DER1 Der1-like domain family, member 1 0.4283
NM_145261 TIM14 DnaJ (Hsp40) homolog, subfamily C, member 19 0.4200
AF447177 GNG10 DnaJ-like protein 0.4710
NM_004125 GNG10 DnaJ-like protein 0.3898
NM_015171 XPO6 Exportin 6 0.2979
CA306634 GTF2H3 General transcription factor IIH, polypeptide 3, 34kDa 0.3048
M57609 GLI3 GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) 0.4337
BC047660 FLJ25422 Hypothetical protein FLJ25422 0.2848
BC035090 KPNA3 Karyopherin alpha 3 (importin alpha 4) 0.4743
AK093917 KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.4578
NM_173827 FLJ38991 Mitochondrial COX18 0.3888
NM_018698 NXT2 Nuclear transport factor 2-like export factor 2 0.4276
BC039468 NUP50 Nucleoporin 50kDa 0.3488
BC032755 PEX13 Peroxisome biogenesis factor 13 0.4637
AK023223 RAB10 RAB10, member RAS oncogene family 0.4531
AL162081 RAB14 RAB14, member RAS oncogene family 0.2783
AB209698 RAB18 RAB18, member RAS oncogene family 0.4513
NM_031296 RAB33B RAB33B, member RAS oncogene family 0.2729
BC014553 RAB3IP RAB3A interacting protein (rabin3) 0.1542
NM_198490 RAB43 RAB43, member RAS oncogene family 0.4308
NM_004162 RAB5A RAB5A, member RAS oncogene family 0.4350
AL136727 RAB6C RAB6C, member RAS oncogene family 0.4727
NM_016530 RAB8B RAB8B, member RAS oncogene family 0.4640
NM_006267 RANBP2 RAN binding protein 2 0.3676
NM_020150 SARA1 SAR1 gene homolog A (S. cerevisiae) 0.3393
AA418814 SEC22L1 SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) 0.3155
AA484677 SEC22L1 SEC22 vesicle trafficking protein-like 1 (S. cerevisiae) 0.2672
NM_031216 SEH1L SEH1-like (S. cerevisiae) 0.3862
BC064351 SRP9 Signal recognition particle 9kDa 0.1788
NM_005843 STAM2 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.3087
BX648363 SNX10 Sorting nexin 10 0.4538
AB209439 SNX15 Sorting nexin 15 0.4678
NM_014758 SNX19 Sorting nexin 19 0.2963
NM_021249 SNX6 Sorting nexin 6 0.4434
NM_004782 SNAP29 Synaptosomal-associated protein, 29kDa 0.3200
AJ420529 STX7 Syntaxin 7 0.4040
BC028028 STXBP3 Syntaxin binding protein 3 0.4085
NM_007269 STXBP3 Syntaxin binding protein 3 0.3236
NM_003262 TLOC1 Translocation protein 1 0.2817
AK094603 FLJ37284 unnamed protein product; Homo sapiens cDNA FLJ37284 fis, clone BRAMY2013590. 0.4770
AL832866 VPS29 Vacuolar protein sorting 29 (yeast) 0.3114
AK092532 FLJ10979 Vacuolar protein sorting 53 (yeast) 0.3635
NM_015336 ZDHHC17 Zinc finger, DHHC-type containing 17 0.4575
AB002303 ZFYVE16 Zinc finger, FYVE domain containing 16 0.2707
(f) WNT 신호 경로(WNT SIGNALING PATHWAY)
NM_007236 CHP Calcium binding protein P22 0.3399
AL137653 BARS C-terminal binding protein 1 0.3506
AB017363 FZD1 Frizzled homolog 1 (Drosophila) 0.4722
NM_017412 FZD3 Frizzled homolog 3 (Drosophila) 0.1618
AB032417 FZD4 Frizzled homolog 4 (Drosophila) 0.3789
AK125150 MAPK8 Mitogen-activated protein kinase 8 0.3782
AK025758 NFATC2 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.2781
NM_000933 PLCB4 Phospholipase C, beta 4 0.3952
AK131561 PRKACA Protein kinase, cAMP-dependent, catalytic, alpha 0.4298
AF026692 SFRP4 Secreted frizzled-related protein 4 0.4533
BC078170 WNT2 Wingless-type MMTV integration site family member 2 0.3878
NM_003392 WNT5A Wingless-type MMTV integration site family, member 5A 0.4489
AY009401 WNT6 Wingless-type MMTV integration site family, member 6 0.3447
(g) 기타(TheOthers)
AL832664 ANP32E Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.3317
NM_138448 ACYP2 Acylphosphatase 2, muscle type 0.3185
AK000643 ASB9 Ankyrin repeat and SOCS box-containing 9 0.4592
NM_175873 LOC134548 Ankyrin repeat domain 43 0.4490
AF279145 ANTXR1 Anthrax toxin receptor 1 0.3494
AB013380 ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 0.3228
M75106 CPB2 Carboxypeptidase B2 (plasma, carboxypeptidase U) 0.4596
AK131472 FLJ16640 CDNAFLJ16640fis,cloneTESTI4028938,moderately similar to Zinc finger protein 85 0.4166
NM_001809 CENPA Centromere protein A, 17kDa 0.4694
AB091343 C10orf3 Centrosomal protein 55kDa 0.4455
BC004543 C15orf23 Chromosome 15 open reading frame 23 0.3956
NM_001012507 C6orf173 Chromosome 6 open reading frame 173 0.4614
AK000972 C9orf40 Chromosome 9 open reading frame 40 0.4469
NM_001801 CDO1 Cysteine dioxygenase, type I 0.2878
NM_018204 CKAP2 Cytoskeleton associated protein 2 0.3130
NM_006716 ASK DBF4 homolog (S. cerevisiae) 0.4161
BC045541 LOC200895 Dihydrofolate reductase-like 1 0.2753
NM_152721 DOK6 Docking protein 6 0.4595
NM_017645 FAM29A Family with sequence similarity 29, member A 0.3814
NM_207418 MGC57827 Family with sequence similarity 72, member A 0.4816
AK055221 FBXO5 F-box protein 5 0.4967
NM_005141 FGB Fibrinogen beta chain 0.4363
AB208919 FGFR1 Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) 0.3246
NM_032117 GAJ GAJ protein 0.3084
NM_020918 GPAM Glycerol-3-phosphate acyltransferase, mitochondrial 0.3408
AB007893 KIAA0433 Histidine acid phosphatase domain containing 1 0.3318
AF032862 HMMR Hyaluronan-mediated motility receptor (RHAMM) 0.3994
AK123495 Q5XI42 Hypothetical gene supported by AL713796 0.3387
NM_018291 FLJ10986 Hypothetical protein FLJ10986 0.4307
AL832022 FLJ13910 Hypothetical protein FLJ13910 0.4640
AL832208 FLJ32312 Hypothetical protein FLJ32312 0.4060
AB037805 KLHL14 Kelch-like 14 (Drosophila) 0.3106
NM_014736 KIAA0101 KIAA0101 0.4374
AB046861 KIAA1641 KIAA1641 0.3217
BC033021 LOC152831 Klotho beta 0.3873
NM_182551 LYCAT Lysocardiolipin acyltransferase 0.3473
NM_002381 MATN3 Matrilin 3 0.1690
AB018342 MYO10 Myosin X 0.4501
BX537509 NET1 Neuroepithelial cell transforming gene 1 0.4179
BX537360 CPSF5 Nudix (nucleoside diphosphate linked moiety X)-type motif 21 0.3747
NM_033222 PSIP1 PC4 and SFRS1 interacting protein 1 0.4576
NM_000277 PAH Phenylalanine hydroxylase 0.3631
NM_176869 PPA2 Pyrophosphatase (inorganic) 2 0.3985
NM_013277 RACGAP1 Rac GTPase activating protein 1 0.3540
NM_004586 RPS6KA3 Ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.1936
BC064610 SEPHS1 Selenophosphate synthetase 1 0.4814
AK075271 SPTLC2L Serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2) 0.3434
XM_496355 LOC440577 Similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 0.2248
XM_371758 LOC389308 Similar to ribosomal protein L10a 0.4247
XM_371470 LOC388907 Similar to ribosomal protein L5; 60S ribosomal protein L5 0.1490
XM_495961 LOC440145 Similar to RIKEN cDNA 2410129H14 0.2230
XM_496301 LOC440517 Similar to zinc finger protein 91 (HPF7, HTF10) 0.2857
BX640965 SLC22A3 Solute carrier family 22 (extraneuronal monoamine transporter), member 3 0.3067
NM_180991 SLCO4C1 Solute carrier organic anion transporter family, member 4C1 0.2490
BC022255 Spc25 Spindle pole body component 25 homolog (S. cerevisiae) 0.2821
BM458612 THRAP6 Thyroid hormone receptor associated protein 6 0.2969
AI300182 PROS1 Transcribed locus, weakly similar to NP_000304.1 protein S (alpha) 0.2130
AL133031 MLR1 Transcription factor MLR1 0.4648
AY358727 FLJ21934 UDP glucuronosyltransferase 2 family, polypeptide A3 0.1343
BC035579 ZNF100 Zinc finger protein 100 0.4610
AB209664 ZNF195 Zinc finger protein 195 0.4953
AY269786 ZNF429 Zinc finger protein 429 0.4502
NM_003423 ZNF43 Zinc finger protein 43 (HTF6) 0.2322
NM_016220 ZNF588 Zinc finger protein 588 0.2746
AK122869 LOC148213 Zinc finger protein 681 0.4151
AK131527 ZNF15L1 Zinc finger protein 708 (KOX8) 0.2967
NM_003430 ZNF91 Zinc finger protein 91 (HPF7, HTF10) 0.4322
NM_152626 ZNF92 Zinc finger protein 92 (HTF12) 0.4466
< 실시예 3> 실시간 RT -PCR( Real - time reverse transcriptase polymerase chain reaction ) 정량
나프탈렌에 의해 발현 유도된 상기 <실시예 2>의 2배 이상 과발현 및 저발현된 유전자 중 나프탈렌에 의해 과발현되는 유전자 24종과 저발현 되는 유전자 21종을 선별하였다. 이들 유전자들은 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) BU945318(metallothionein 2A), 유전자 등록번호(Genebank) BM926478(Retinol binding protein 1, cellular), 유전자 등록번호(Genebank) X02812(Transforming growth factor, beta 1(Camurati-Engelmann disease)), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) BC042390(Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)), 유전자 등록번호(Genebank) NM_017572(MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) NM_173481(Chromosome 19 open reading frame 21), 유전자 등록번호(Genebank) NM_032468(Aspartate beta-hydroxylase), 유전자 등록번호(Genebank) AY247738(Tribbles homolog 3(Drosophila)), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AA669162(Adenosine monophosphate deaminase(isoform E)), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) NM_003255(TIMP metallopeptidase inhibitor 2), 유전자 등록번호(Genebank) NM_080388(S100 calcium binding protein A16), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_001013632(polo-like kinase 3(Drosophila)), 유전자 등록번호(Genebank) BQ683841(S100 calcium binding protein A11(calgizzarin)), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769(CD9 antigen(p24)), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) AF167706(Cysteine rich transmembrane BMP regulator 1(chordin-like)), 유전자 등록번호(Genebank) AB046861(KIAA1641), 유전자 등록번호(Genebank) BC068588(Similar to CG32820-PA, isoform A), 유전자 등록번호(Genebank) AY358727(UDP glucuronosyltransferase 2 family, polypeptide A3), 유전자 등록번호(Genebank) NM_017768(Leucine rich repeat containing 40), 유전자 등록번호(Genebank) AA074156(Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus]), 유전자 등록번호(Genebank) XM_291202(Zinc finger protein 479), 유전자 등록번호(Genebank) AB013380(ATP-binding cassette, sub-family B(MDR/TAP), member 10), 유전자 등록번호(Genebank) NM_180991(Solute carrier organic anion transporter family, member 4C1), 유전자 등록번호(Genebank) BC022255(Spindle pole body component 25 homolog(S. cerevisiae)), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_145697(Cell division cycle associated 1), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa), 유전자 등록번호(Genebank) BX640888(Glypican 6), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410(MAD2 mitotic arrest deficient-like 1(yeast)), 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa)이다.
상기 유전자들의 발현변화 정도를 조사 및 정량하기 위해 My IQ 실시간 PCR(My IQ Real-time PCR)(Bio-rad, USA)을 이용하여 정량적인 실시간 RT-PCR을 실시하였다.
구체적으로, 올리고 dT 프라이머와 Superscript kit(Omniscipt™ kit, Qiagen, Co., USA)를 이용하여 역전사반응을 수행하여 cDNA를 합성하였다. PCR 산물을 정량하기 위하여 사이버그린(SYBR Green) I 염색(Bio-rad, USA)으로 염색하였다. 사이버그린 I 염색은 이중나선 DNA에 결합하는 염색법으로서, PCR 과정 동안 이중나선 DNA가 생성될수록 형광강도(fluroscense intensity)가 증가하게 된다.
먼저, PCR에 이용한 표적 유전자와 내재성(endogenous) 대조군(GAPDH)에 대한 프라이머를 사이버그린 마스터 믹스(Master mix)에 첨가하여 PCR을 실시한 후, 적절한 농도를 선택하는 프라이머 적합화(primer optimization) 과정을 수행하였다. 합성된 cDNA 시료와 각각의 프라이머(표 4)를 혼합하고, 사이버그린 마스터 믹스를 첨가한 후 PCR를 수행하였고, 정량 소프트웨어(software)를 사용하여 분석하였다(표 5).
프라이머 서열
등록번호 유전자명 PCR 프라이머 서열
BM913048 TIMP metallopeptidase inhibitor 1 센스
(서열번호1)		 GATACTTCCACAGGTCCCACAAC
안티센스
(서열번호2)		 GCAAGAGTCCATCCTGCAGTT
BU945318 metallothionein 2A 센스
(서열번호3)		 CTCTAGCCGCCTCTTCAGC
안티센스
(서열번호4)		 ACTCTTTGCATTTGCAGGAAC
BM926478 Retinol binding protein 1, cellular 센스
(서열번호5)		 AGGCATAGATGACCGCAAGT
안티센스
(서열번호6)		 ACCCTTCTGCACACACTGG
X02812 Transforming growth factor, beta 1(Camurati-Engelmann disease) 센스
(서열번호7)		 GCAGCACGTGGAGCTGTA
안티센스
(서열번호8)		 CAGCCGGTTGCTGAGGTA
NM_004864 Growth differentiation factor 15 센스
(서열번호9)		 CCTGAGACACCCGATTCCT
안티센스
(서열번호10)		 ACAGTTCCATCAGACCAGCC
NM_003897 Immediate early response 3 센스
(서열번호11)		 AGCCCTTTAATCTGACTTCGGAGC
안티센스
(서열번호12)		 CAGGTACGCCTGGTGTTTCTTTGT
BC042390　 Vesicle transport through interaction with t-SNAREs homolog 1B(yeast) 센스
(서열번호13)		 GGGGGACTAACCTATCGAGAA
안티센스
(서열번호14)		 GATCCAGTGCTGATAGCAACC
NM_017572 MAP kinase interacting serine/threonine kinase 2 센스
(서열번호15)		 CCATGGTCCTGCAGAGGT
안티센스
(서열번호16)		 TTCTGACCAGTCCTCCAGGT
NM_173481 Chromosome 19 open reading frame 21 센스
(서열번호17)		 TCGGACGGTATCAACTCAGA
안티센스
(서열번호18)		 TCCTCCTCACTGGCGTAGAT
NM_032468 Aspartate beta-hydroxylase 센스
(서열번호19)		 TGCTGATGCAGACCTATCCAGGAA
안티센스
(서열번호20)		 TGTCATCTTTGTCTCGGGATGCCA
AY247738 Tribbles homolog 3 (Drosophila) 센스
(서열번호21)		 GTCTTCGCTGACCGTGAGA
안티센스
(서열번호22)		 CAGTCAGCACGCAGGAGTC
AK095363 Aquaporin 3 센스
(서열번호23)		 TTCACGATCCACCCTTTCAGGCTA
안티센스
(서열번호24)		 ACACATACCTGCTGCCCATTCTCT
AA669162 Adenosine monophosphate deaminase(isoform E) 센스
(서열번호25)		 AGGTCAAAGAAGCTGCTGCCAAAC
안티센스
(서열번호26)		 TGGACTCATCATCCACGCTGTCAA
NM_003516 Histone 2, H2aa 센스
(서열번호27)		 GAACTGAACAAGCTGCTGGGCAAA
안티센스
(서열번호28)		 TCTCCGTCTTCTTAGGGAGCAGTA
NM_003255 TIMP metallopeptidase inhibitor 2 센스
(서열번호29)		 CGACATTTATGGCAACCCTATCA
안티센스
(서열번호30)		 CAGGCCCTTTGAACATCTTTATCT
NM_080388 S100 calcium binding protein A16 센스
(서열번호31)		 CCAGAAAGAGCTGAACCACATGCT
안티센스
(서열번호32)		 AGGTCCAGTACTCATCGAAGCTGA
BX649164 serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 센스
(서열번호33)		 CAGACCAAGAGCCTCTCCAC
안티센스
(서열번호34)		 ATCACTTGGCCCATGAAAAG
NM_001013632 polo-like kinase 3 (Drosophila) 센스
(서열번호35)		 GACTACTCCAATAAGTTCGGCTTTG
안티센스
(서열번호36)		 CATATGTGTGCCATCGTTGAAGA
BQ683841 S100 calcium binding protein A11(calgizzarin) 센스
(서열번호37)		 AGTCCCTGATTGCTGTCTTCCAGA
안티센스
(서열번호38)		 ACCAGGGTCCTTCTGGTTCTTTGT
Y11307 Cysteine-rich, angiogenic inducer, 61 센스
(서열번호39)		 ATTGTAGAAAGGAAGCCTTGCTCAT
안티센스
(서열번호40)		 TCCAATCGTGGCTGCATTAG
AK094474 Ras homolog gene family, member C 센스
(서열번호41)		 ACCTGCCTCCTCATCGTCTTC
안티센스
(서열번호42)		 CACCTGCTTGCCGTCCAC
NM_001769 CD9 antigen(p24) 센스
(서열번호43)		 GCACCAAGTGCATCAAATACCTGC
안티센스
(서열번호44)		 AGCCATAGTCCAATGGCAAGGACA
BC035124 MSFL2541 센스
(서열번호45)		 TTCGCCGTCCTTTACATCTAC
안티센스
(서열번호46)		 AGAGCCTGGGGACTCACAT
NM_000499 Cytochrome P450, family 1, subfamily A, polypeptide 1 센스
(서열번호47)		 CACCATCCCCCACAGCAC
안티센스
(서열번호48)		 ACAAAGACACAACGCCCCTT
AF167706 Cysteine rich transmembrane BMP regulator 1(chordin-like) 센스
(서열번호49)		 TGCCCACAGTGTACAGATCAACCT
안티센스
(서열번호50)		 ATGCAGATGCAGCTGGTACAAACG
AB046861 KIAA1641 센스
(서열번호51)		 AAGGAGGGACAACAATCTGGGACA
안티센스
(서열번호52)		 TCACTTGTAGCCTTTGAGGGTGGT
BC068588 Similar to CG32820-PA, isoform A 센스
(서열번호53)		 ATAGCATCGGGCAGGACTAATGGA
안티센스
(서열번호54)		 GAAAGAGGGTGTGATGTGGACCAT
AY358727 UDP glucuronosyltransferase 2 family, polypeptide A3 센스
(서열번호55)		 GAAAAGGCTAATATCATTGCTTCAG
안티센스
(서열번호56)		 TTCCTTTGTACCTCCATAACACC
NM_017768 Leucine rich repeat containing 40 센스
(서열번호57)		 TGCCGCAGTGTGTCTGGAGAATAA
안티센스
(서열번호58)		 TGCTCCCACCATCTTTCAGTAGCA
AA074156 Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus] 센스
(서열번호59)		 AGGCTGGAACCTATTTGCCTCAGT
안티센스
(서열번호60)		 TGCGAAACAATTGCTGGCTTCACG
XM_291202 Zinc finger protein 479 센스
(서열번호61)		 ATGGTAGCCAAACACCCAGT
안티센스
(서열번호62)		 TGAATCTTTGATGCCCTGCT
AB013380 ATP-binding cassette, sub-family B(MDR/TAP), member 10 센스
(서열번호63)		 TCAGCCTTTCCATTCCGTCAGGAT
안티센스
(서열번호64)		 TTTGGATCTCAGCCACACTGGGTT
NM_180991 Solute carrier organic anion transporter family, member 4C1 센스
(서열번호65)		 CCAGCTTCGCAGCTACTCTT
안티센스
(서열번호66)		 CCACCTAAAATTTGACCGAGAG
BC022255 Spindle pole body component 25 homolog(S. cerevisiae) 센스
(서열번호67)		 GAATGGTTGAGATGTTTCTGGA
안티센스
(서열번호68)		 GCAATCAATTTTAACAAGTTATCCTTT
AK074377 Chromosome 19 open reading frame 31 센스
(서열번호69)		 CTGGTACGACGCGGAGAT
안티센스
(서열번호70)		 CGACAGTCGTTCAGAGAATCA
BX640965 Solute carrier family 22(extraneuronal monoamine transporter), member 3 센스
(서열번호71)		 GCCCTGTTCCAGCAATAAGA
안티센스
(서열번호72)		 GAGAGCCAAAAATGTCCCAA
CR600021 High-mobility group box 2 센스
(서열번호73)		 CTTGGCACGATATGCAGCAA
안티센스
(서열번호74)		 CAGCCAAAGATAAACAACCATATGA
NM_006101 Kinetochore associated 2 센스
(서열번호75)		 TGCTACACATGTTGGGTCTGTA
안티센스
(서열번호76)		 CCGAGAGATCTTCTGACATGC
NM_145697 Cell division cycle associated 1 센스
(서열번호77)		 TGCCTTCATGTCAGTTGGAAGTGC
안티센스
(서열번호78)		 TTTGGTCCTCCAAGTTCAGGCTCT
AB091343 Centrosomal protein 55 kDa 센스
(서열번호79)		 GCTGTGCATTTCTCTTGGCAGTGA
안티센스
(서열번호80)		 TAGACGCTGCTCACCACATTCTGT
BX640888 Glypican 6 센스
(서열번호81)		 ACACTGACCAGCTCAAGCCATTTG
안티센스
(서열번호82)		 GACAAAGGTCCTGGCAGCAATGAA
NM_018492 PDZ binding kinase 센스
(서열번호83)		 TCTGGACTGAGAGTGGCTTTCACA
안티센스
(서열번호84)		 AGCCAAGCTTCTGCATAAACGGAG
NM_003318 TTK protein kinase 센스
(서열번호85)		 TCATGCCCATTTGGAAGAGTCCCA
안티센스
(서열번호86)		 AGGCACAACCAAATCTCGGCATTC
U65410 MAD2 mitotic arrest deficient-like 1(yeast) 센스
(서열번호87)		 ACTTAAATATCTCCCTACCTATACTGAGTCAA
안티센스
(서열번호88)		 TAGTAACTGTAGATGGAAAAACTTGTGCTA
NM_001067 Topoisomerase(DNA) II alpha 170kDa 센스
(서열번호89)		 CTAGTTAATGCTGCGGACAACA
안티센스
(서열번호90)		 CATTTCGACCACCTGTCACTT
실시간 RT - PCR 정량 결과
등록번호 유전자명 약어 마이크로어레이
(Cy3/Cy5비율) 		실시간 PCR
(상대적배율)
과발현 유전자
BM913048 TIMP metallopeptidase inhibitor 1 TIMP1 8.27 9.19
BU945318 metallothionein 2A MT2A 6.24 5.50
BM926478 Retinol binding protein 1, cellular RBP1 5.95 7.82
X02812 Transforming growth factor, beta 1(Camurati-Engelmann disease) TGFB1 5.35 2.31
NM_004864 Growth differentiation factor 15 GDF15 4.76 5.59
NM_003897 Immediate early response 3 IER3 4.67 3.76
BC042390 Vesicle transport through interaction with t-SNAREs homolog 1B(yeast) VTI1B 4.47 6.31
NM_017572 MAP kinase interacting serine/threonine kinase 2 MKNK2 4.31 3.37
NM_173481 Chromosome 19 open reading frame 21 C19orf21 4.28 5.97
NM_032468 Aspartate beta-hydroxylase ASPH 3.95 9.27
AY247738 Tribbles homolog 3 (Drosophila) TRIB3 3.69 2.51
AK095363 Aquaporin 3 AQP3 2.95 16.34
AA669162 Adenosine monophosphate deaminase(isoform E) AMPD3 2.80 21.51
NM_003516 Histone 2, H2aa HIST2H2AA 2.79 1.69
NM_003255 TIMP metallopeptidase inhibitor 2 TIMP2 2.69 2.22
NM_080388 S100 calcium binding protein A16 S100A16 2.63 3.32
BX649164 serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 SERPINE1 2.53 4.54
NM_001013632 polo-like kinase 3 (Drosophila) PLK3 2.51 3.26
BQ683841 S100 calcium binding protein A11(calgizzarin) S100A11 2.44 2.16
Y11307 Cysteine-rich, angiogenic inducer, 61 CYR61 2.43 2.64
AK094474 Ras homolog gene family, member C RHOC 2.25 2.98
NM_001769 CD9 antigen(p24) CD9 2.08 3.03
BC035124 MSFL2541 UNQ2541 2.00 2.62
NM_000499 Cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A1 1.66 4.11
저발현 유전자
AF167706 Cysteine rich transmembrane BMP regulator 1(chordin-like) CRIM1 0.10 0.60
AB046861 KIAA1641 KIAA1641 0.11 0.23
BC068588 Similar to CG32820-PA, isoform A LOC653071 0.12 0.54
AY358727 UDP glucuronosyltransferase 2 family, polypeptide A3 FLJ21934 0.13 0.58
NM_017768 Leucine rich repeat containing 40 LRRC40 0.14 0.60
AA074156 Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B [Mus musculus] ITM2B 0.15 0.65
XM_291202 Zinc finger protein 479 ZNF479 0.23 0.56
AB013380 ATP-binding cassette, sub-family B(MDR/TAP), member 10 ABCB10 0.25 0.63
NM_180991 Solute carrier organic anion transporter family, member 4C1 SLCO4C1 0.25 0.35
BC022255 Spindle pole body component 25 homolog(S. cerevisiae) Spc25 0.28 0.48
AK074377 Chromosome 19 open reading frame 31 UHRF1 0.31 0.30
BX640965 Solute carrier family 22(extraneuronal monoamine transporter), member 3 SLC22A3 0.31 0.68
CR600021 High-mobility group box 2 HMGB2 0.34 0.67
NM_006101 Kinetochore associated 2 KNTC2 0.37 0.58
NM_145697 Cell division cycle associated 1 CDCA1 0.41 0.55
AB091343 Centrosomal protein 55kDa C10orf3 0.45 0.38
BX640888 Glypican 6 GPC6 0.46 0.31
NM_018492 PDZ binding kinase PBK 0.47 0.59
NM_003318 TTK protein kinase TTK 0.49 0.22
U65410 MAD2 mitotic arrest deficient-like 1(yeast) MAD2L1 0.50 0.58
NM_001067 Topoisomerase(DNA) II alpha 170kDa TOP2A 0.56 0.12
그 결과, 24종의 과발현 유전자들 및 21종의 저발현 유전자의 유전자 발현 양상은 나프탈렌에 의한 유전자 발현을 조사한 올리고 마이크로어레이 결과와 매우 유사하게 나타남을 확인하였다.
도 1은 나프탈렌(Naphthalene)의 인간 간암 세포주에서의 세포 독성을 나타내는 그래프이다.
도 2는 마이크로어레이 칩을 이용한 나프탈렌을 처리한 인간 간암 세포주의 유전자 발현 양상을 분석한 결과를 나타내는 그림이다.
<110> Korea Institute of Science and Technology <120> Biomarker for identification of exposure to naphthalene and the method of identification using thereof <130> 8p-02-06 <160> 90 <170> KopatentIn 1.71 <210> 1 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 sense primer <400> 1 gatacttcca caggtcccac aac 23 <210> 2 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 1 antisense primer <400> 2 gcaagagtcc atcctgcagt t 21 <210> 3 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A sense primer <400> 3 ctctagccgc ctcttcagc 19 <210> 4 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> metallothionein 2A antisense primer <400> 4 actctttgca tttgcaggaa c 21 <210> 5 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular sense primer <400> 5 aggcatagat gaccgcaagt 20 <210> 6 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Retinol binding protein 1, cellular antisense primer <400> 6 acccttctgc acacactgg 19 <210> 7 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 sense primer <400> 7 gcagcacgtg gagctgta 18 <210> 8 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Transforming growth factor, beta 1 antisense primer <400> 8 cagccggttg ctgaggta 18 <210> 9 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 sense primer <400> 9 cctgagacac ccgattcct 19 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Growth differentiation factor 15 antisense primer <400> 10 acagttccat cagaccagcc 20 <210> 11 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 sense primer <400> 11 agccctttaa tctgacttcg gagc 24 <210> 12 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Immediate early response 3 antisense primer <400> 12 caggtacgcc tggtgtttct ttgt 24 <210> 13 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B sense primer <400> 13 gggggactaa cctatcgaga a 21 <210> 14 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Vesicle transport through interaction with t-SNAREs homolog 1B antisense primer <400> 14 gatccagtgc tgatagcaac c 21 <210> 15 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine/threonine kinase 2 sense primer <400> 15 ccatggtcct gcagaggt 18 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> MAP kinase interacting serine/threonine kinase 2 antisense primer <400> 16 ttctgaccag tcctccaggt 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 sense primer <400> 17 tcggacggta tcaactcaga 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 21 antisense primer <400> 18 tcctcctcac tggcgtagat 20 <210> 19 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase sense primer <400> 19 tgctgatgca gacctatcca ggaa 24 <210> 20 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aspartate beta-hydroxylase antisense primer <400> 20 tgtcatcttt gtctcgggat gcca 24 <210> 21 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 sense primer <400> 21 gtcttcgctg accgtgaga 19 <210> 22 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> Tribbles homolog 3 antisense primer <400> 22 cagtcagcac gcaggagtc 19 <210> 23 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aquaporin 3 sense primer <400> 23 ttcacgatcc accctttcag gcta 24 <210> 24 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Aquaporin 3 antisense primer <400> 24 acacatacct gctgcccatt ctct 24 <210> 25 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase sense primer <400> 25 aggtcaaaga agctgctgcc aaac 24 <210> 26 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Adenosine monophosphate deaminase antisense primer <400> 26 tggactcatc atccacgctg tcaa 24 <210> 27 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa sense primer <400> 27 gaactgaaca agctgctggg caaa 24 <210> 28 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Histone 2, H2aa antisense primer <400> 28 tctccgtctt cttagggagc agta 24 <210> 29 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 sense primer <400> 29 cgacatttat ggcaacccta tca 23 <210> 30 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TIMP metallopeptidase inhibitor 2 antisense primer <400> 30 caggcccttt gaacatcttt atct 24 <210> 31 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 sense primer <400> 31 ccagaaagag ctgaaccaca tgct 24 <210> 32 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A16 antisense primer <400> 32 aggtccagta ctcatcgaag ctga 24 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 snese primer <400> 33 cagaccaaga gcctctccac 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 antisense primer <400> 34 atcacttggc ccatgaaaag 20 <210> 35 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) snese primer <400> 35 gactactcca ataagttcgg ctttg 25 <210> 36 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> polo-like kinase 3 (Drosophila) antisense primer <400> 36 catatgtgtg ccatcgttga aga 23 <210> 37 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) sense primer <400> 37 agtccctgat tgctgtcttc caga 24 <210> 38 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> S100 calcium binding protein A11 (calgizzarin) antisense primer <400> 38 accagggtcc ttctggttct ttgt 24 <210> 39 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> Cysteine-rich, angiogenic inducer, 61 snese primer <400> 39 attgtagaaa ggaagccttg ctcat 25 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Cysteine-rich, angiogenic inducer, 61 antisense primer <400> 40 tccaatcgtg gctgcattag 20 <210> 41 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C sense primer <400> 41 acctgcctcc tcatcgtctt c 21 <210> 42 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Ras homolog gene family, member C antisense primer <400> 42 cacctgcttg ccgtccac 18 <210> 43 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) sense primer <400> 43 gcaccaagtg catcaaatac ctgc 24 <210> 44 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> CD9 antigen (p24) antisense primer <400> 44 agccatagtc caatggcaag gaca 24 <210> 45 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 sense primer <400> 45 ttcgccgtcc tttacatcta c 21 <210> 46 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> MSFL2541 antisense primer <400> 46 agagcctggg gactcacat 19 <210> 47 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 sense primer <400> 47 caccatcccc cacagcac 18 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Cytochrome P450, family 1, subfamily A, polypeptide 1 antisense primer <400> 48 acaaagacac aacgcccctt 20 <210> 49 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cysteine rich transmembrane BMP regulator 1(chordin-like) sense primer <400> 49 tgcccacagt gtacagatca acct 24 <210> 50 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cysteine rich transmembrane BMP regulator 1(chordin-like) antisense primer <400> 50 atgcagatgc agctggtaca aacg 24 <210> 51 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 sense primer <400> 51 aaggagggac aacaatctgg gaca 24 <210> 52 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> KIAA1641 antisense primer <400> 52 tcacttgtag cctttgaggg tggt 24 <210> 53 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A sense primer <400> 53 atagcatcgg gcaggactaa tgga 24 <210> 54 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Similar to CG32820-PA, isoform A antisense primer <400> 54 gaaagagggt gtgatgtgga ccat 24 <210> 55 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 snese primer <400> 55 gaaaaggcta atatcattgc ttcag 25 <210> 56 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> UDP glucuronosyltransferase 2 family, polypeptide A3 antisense primer <400> 56 ttcctttgta cctccataac acc 23 <210> 57 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 sense primer <400> 57 tgccgcagtg tgtctggaga ataa 24 <210> 58 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Leucine rich repeat containing 40 antisense primer <400> 58 tgctcccacc atctttcagt agca 24 <210> 59 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B[Mus musculus] sense primer <400> 59 aggctggaac ctatttgcct cagt 24 <210> 60 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Transcribed locus, strongly similar to NP_032436.1 integral membrane protein 2B[Mus musculus] antisense primer <400> 60 tgcgaaacaa ttgctggctt cacg 24 <210> 61 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 sense primer <400> 61 atggtagcca aacacccagt 20 <210> 62 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Zinc finger protein 479 antisense primer <400> 62 tgaatctttg atgccctgct 20 <210> 63 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR/TAP), member 10 sense primer <400> 63 tcagcctttc cattccgtca ggat 24 <210> 64 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> ATP-binding cassette, sub-family B (MDR/TAP), member 10 antisense primer <400> 64 tttggatctc agccacactg ggtt 24 <210> 65 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 sense primer <400> 65 ccagcttcgc agctactctt 20 <210> 66 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier organic anion transporter family, member 4C1 antisense primer <400> 66 ccacctaaaa tttgaccgag ag 22 <210> 67 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Spindle pole body component 25 homolog (S. cerevisiae) sense primer <400> 67 gaatggttga gatgtttctg ga 22 <210> 68 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> Spindle pole body component 25 homolog (S. cerevisiae) antisense primer <400> 68 gcaatcaatt ttaacaagtt atccttt 27 <210> 69 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 sense primer <400> 69 ctggtacgac gcggagat 18 <210> 70 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Chromosome 19 open reading frame 31 antisense primer <400> 70 cgacagtcgt tcagagaatc a 21 <210> 71 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22(extraneuronal monoamine transporter), member 3 sense primer <400> 71 gccctgttcc agcaataaga 20 <210> 72 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> Solute carrier family 22(extraneuronal monoamine transporter), member 3 antisense primer <400> 72 gagagccaaa aatgtcccaa 20 <210> 73 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 sense primer <400> 73 cttggcacga tatgcagcaa 20 <210> 74 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> High-mobility group box 2 antisense primer <400> 74 cagccaaaga taaacaacca tatga 25 <210> 75 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 sense primer <400> 75 tgctacacat gttgggtctg ta 22 <210> 76 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Kinetochore associated 2 antisense primer <400> 76 ccgagagatc ttctgacatg c 21 <210> 77 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 sense primer <400> 77 tgccttcatg tcagttggaa gtgc 24 <210> 78 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Cell division cycle associated 1 antisense primer <400> 78 tttggtcctc caagttcagg ctct 24 <210> 79 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa sense primer <400> 79 gctgtgcatt tctcttggca gtga 24 <210> 80 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Centrosomal protein 55 kDa antisense primer <400> 80 tagacgctgc tcaccacatt ctgt 24 <210> 81 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Glypican 6 sense primer <400> 81 acactgacca gctcaagcca tttg 24 <210> 82 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> Glypican 6 antisense primer <400> 82 gacaaaggtc ctggcagcaa tgaa 24 <210> 83 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 83 tctggactga gagtggcttt caca 24 <210> 84 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> PDZ binding kinase antisense primer <400> 84 agccaagctt ctgcataaac ggag 24 <210> 85 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase sense primer <400> 85 tcatgcccat ttggaagagt ccca 24 <210> 86 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> TTK protein kinase antisense primer <400> 86 aggcacaacc aaatctcggc attc 24 <210> 87 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1(yeast) sense primer <400> 87 acttaaatat ctccctacct atactgagtc aa 32 <210> 88 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> MAD2 mitotic arrest deficient-like 1(yeast) antisense primer <400> 88 tagtaactgt agatggaaaa acttgtgcta 30 <210> 89 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> Topoisomerase(DNA) II alpha 170 kDa sense primer <400> 89 ctagttaatg ctgcggacaa ca 22 <210> 90 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> Topoisomerase(DNA) II alpha 170 kDa antisense primer <400> 90 catttcgacc acctgtcact t 21

Claims (15)

  1. 하기 모든 유전자의 핵산서열의 전부 또는 그의 상보가닥 분자가 집적된 나프탈렌에 대한 세포주기조절 관련 유전자 발현 여부 확인용 DNA 마이크로어레이 칩:
    유전자 등록번호(Genebank) CR606241(ACTG1, Actin, gamma 1), 유전자 등록번호(Genebank) NM_012127(CIZ1, CDKN1A interacting zinc finger protein 1), 유전자 등록번호(Genebank) AK057576(CHFR, Checkpoint with forkhead and ring finger domains), 유전자 등록번호(Genebank) NM_005255(GAK, Cyclin G associated kinase), 유전자 등록번호(Genebank) NM_078487(CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) AK094316(MAD2L2, MAD2 mitotic arrest deficient-like 2(yeast)), 유전자 등록번호(Genebank) NM_002595(PCTK2, PCTAIRE protein kinase 2), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform b, alpha subunit 45kDa), 유전자 등록번호(Genebank) X06374(PDGFA, Platelet-derived growth factor alpha polypeptide), 유전자 등록번호(Genebank) NM_001722(POLR3D, Polymerase(RNA) III(DNA directed) polypeptide D, 44kDa), 유전자 등록번호(Genebank) NM_002808(PSMD2, Proteasome(prosome, macropain) 26S subunit, non-ATPase, 2), 유전자 등록번호(Genebank) BC038504(SNF1LK, SNF1-like kinase), 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) NM_000548(TSC2, Tuberous sclerosis 2), 유전자 등록번호(Genebank) AK223618(ZBTB17, Zinc finger and BTB domain containing 17), 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) BC016344(ACPP, Acid phosphatase, prostate), 유전자 등록번호(Genebank) BM921310(ANAPC10, Anaphase promoting complex subunit 10), 유전자 등록번호(Genebank) NM_153186(ANKRD15, Ankyrin repeat domain 15), 유전자 등록번호(Genebank) AY367065(ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)), 유전자 등록번호(Genebank) NM_004071(CLK1, CDC-like kinase 1), 유전자 등록번호(Genebank) CR933728(CDC2 Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_044472(CDC42, Cell division cycle 42(GTP binding protein, 25kDa)), 유전자 등록번호(Genebank) NM_004365(CETN3, Centrin, EF-hand protein, 3(CDC31 homolog, yeast)), 유전자 등록번호(Genebank) NM_016343(CENPF, Centromere protein F, 350/400ka(mitosin)), 유전자 등록번호(Genebank) BC050310(C10orf9, Chromosome 10 open reading frame 9), 유전자 등록번호(Genebank) NM_016446(C9orf127, Chromosome 9 open reading frame 127), 유전자 등록번호(Genebank) AY257469(CIT, Citron(rho-interacting, serine/threonine kinase 21)), 유전자 등록번호(Genebank) NM_001761(CCNF, Cyclin F), 유전자 등록번호(Genebank) NM_004354(CCNG2, Cyclin G2), 유전자 등록번호(Genebank) NM_004064(CDKN1B, Cyclin-dependent kinase inhibitor 1B(p27, Kip1)), 유전자 등록번호(Genebank) NM_007068(DMC1, DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination(yeast)), 유전자 등록번호(Genebank) AK025142(BPA, dystonin), 유전자 등록번호(Genebank) NM_001950(E2F4, E2F transcription factor 4, p107/p130-binding), 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) AJ245671(EGFL6, EGF-like-domain, multiple 6),전자 등록번호(Genebank) NM_004450(ERH, Enhancer of rudimentary homolog(Drosophila)), 유전자 등록번호(Genebank) AL832041(ESCO1, Establishment of cohesion 1 homolog 1(S. cerevisiae)), 유전자 등록번호(Genebank) AL832666(ESCO2, Establishment of cohesion 1 homolog 2(S. cerevisiae)), 유전자 등록번호(Genebank) AK126048(FLJ44060, FLJ44060 protein), 유전자 등록번호(Genebank) BI494022(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) NM_014707(HDAC9, Histone deacetylase 9), 유전자 등록번호(Genebank) BC067253(FLJ40432, Hypothetical protein FLJ40432), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) BC040410(MAPRE1, Microtubule-associated protein, RP/EB family, member 1), 유전자 등록번호(Genebank) AB033337(MPHOSPH1, M-phase phosphoprotein 1), 유전자 등록번호(Genebank) L20321(NEK4, NIMA(never in mitosis gene a)-related kinase 4), 유전자 등록번호(Genebank) AJ627032(NIPBL, Nipped-B homolog(Drosophila)), 유전자 등록번호(Genebank) AL575067(NUDC, Nuclear distribution gene C homolog(A. nidulans)), 유전자 등록번호(Genebank) NM_003884(PCAF, P300/CBP-associated factor), 유전자 등록번호(Genebank) AL833922(PAPD5, PAP associated domain containing 5), 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_016205(PDGFC, Platelet derived growth factor C), 유전자 등록번호(Genebank) NM_000430(PAFAH1B1, Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa), 유전자 등록번호(Genebank) NM_006259(PRKG2, Protein kinase, cGMP-dependent, type II), 유전자 등록번호(Genebank) NM_002709(PPP1CB, Protein phosphatase 1, catalytic subunit, beta isoform), 유전자 등록번호(Genebank) NM_003463(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BX647606(PTMA, Prothymosin, alpha(gene sequence 28)), 유전자 등록번호(Genebank) BC068483(RINT-1, Rad50-interacting protein 1), 유전자 등록번호(Genebank) NM_006325(RAN, RAN, member RAS oncogene family), 유전자 등록번호(Genebank) NM_213590(RFP2, Ret finger protein 2), 유전자 등록번호(Genebank) NM_006910(RBBP6, Retinoblastoma binding protein 6), 유전자 등록번호(Genebank) BC060806(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) BX648668(RECK, Reversion-inducing-cysteine-rich protein with kazal motifs), 유전자 등록번호(Genebank) AB208875(SEPT10, Septin 10), 유전자 등록번호(Genebank) AB209677(SEPT7, Septin 7), 유전자 등록번호(Genebank) BX649128(SESN3, Sestrin 3), 유전자 등록번호(Genebank) XM_497098(LOC441488, Similar to Transcription factor Dp-1(E2F dimerization partner 1)(DRTF1-polypeptide-1)(DRTF1)), 유전자 등록번호(Genebank) AK131071(SLC31A2, Solute carrier family 31(copper transporters), member 2), 유전자 등록번호(Genebank) NM_006930(SKP1A, S-phase kinase-associated protein 1A(p19A)), 유전자 등록번호(Genebank) NM_006542(SPHAR, S-phase response(cyclin-related)), 유전자 등록번호(Genebank) BX647885(STMN1, Stathmin 1/oncoprotein 18), 유전자 등록번호(Genebank) NM_014574(STRN3, Striatin, calmodulin binding protein 3), 유전자 등록번호(Genebank) NM_003176(SYCP1, Synaptonemal complex protein 1), 유전자 등록번호(Genebank) BM674777(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_007375(TARDBP, TAR DNA binding protein), 유전자 등록번호(Genebank) NM_006701(TXNL4A, Thioredoxin-like 4A), 유전자 등록번호(Genebank) NM_030756(TCF7L2, Transcription factor 7-like 2(T-cell specific, HMG-box)), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) NM_000368(TSC1, Tuberous sclerosis 1), 유전자 등록번호(Genebank) NM_006826(YWHAQ, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide), 유전자 등록번호(Genebank) NM_001032410(USP16, Ubiquitin specific peptidase 16), 유전자 등록번호(Genebank) AK095164(KRAS2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog).
  2. 삭제
  3. 삭제
  4. 삭제
  5. 1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;
    2) 단계 1)의 실험군 및 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질로 표지하는 단계;
    3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 제 1항의 DNA 마이크로어레이칩과 혼성화시키는 단계;
    4) 반응한 DNA 마이크로어레이칩을 분석하는 단계; 및
    5) 분석한 데이터에서 제 1항의 DNA 마이크로어레이칩에 집적된 유전자의 발현 정도를 대조군과 비교하여 확인하는 단계를 포함하는 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부를 확인하는 방법.
  6. 제 5항에 있어서, 단계 1)의 체세포는 인간 간 세포 또는 인간 간암 세포인 것을 특징으로 하는 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부를 확인하는 방법.
  7. 제 6항에 있어서, 상기 인간 간암 세포는 HepG2인 것을 특징으로 하는 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부를 확인하는 방법.
  8. 제 5항에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택하여 사용하는 것을 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부를 확인하는 방법.
  9. 삭제
  10. 삭제
  11. 삭제
  12. 제 1항의 DNA 마이크로어레이 칩을 포함하는 것을 특징으로 하는 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부 확인용 키트.
  13. 제 12항에 있어서, 인간 간 세포 또는 인간 간암 세포를 추가적으로 포함하는 것을 특징으로 하는 나프탈렌에 대한 세포주기 조절 관련 유전자 발현 여부 확인용 키트.
  14. 삭제
  15. 삭제
KR1020080015344A 2008-02-20 2008-02-20 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 KR100968762B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020080015344A KR100968762B1 (ko) 2008-02-20 2008-02-20 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020080015344A KR100968762B1 (ko) 2008-02-20 2008-02-20 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법

Publications (2)

Publication Number Publication Date
KR20090090083A KR20090090083A (ko) 2009-08-25
KR100968762B1 true KR100968762B1 (ko) 2010-07-08

Family

ID=41208033

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020080015344A KR100968762B1 (ko) 2008-02-20 2008-02-20 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법

Country Status (1)

Country Link
KR (1) KR100968762B1 (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101735415B1 (ko) 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
KR20230064006A (ko) 2021-11-01 2023-05-10 동국대학교 산학협력단 페놀 노출 여부 평가용 바이오마커 및 이를 이용한 페놀 노출 여부 평가 방법

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101432171B1 (ko) * 2013-01-22 2014-08-22 한국원자력의학원 Ｃｄｋ11ａ를 측정하는 제제를 포함하는 방사선 저항성 또는 민감성 진단용 조성물 및 이의 용도
KR20200048741A (ko) 2018-10-30 2020-05-08 (주)아모레퍼시픽 Ell 발현 촉진 물질을 포함하는 피부 장벽기능 강화용 조성물 및 ell 촉진 물질의 스크리닝 방법
CN116586048B (zh) * 2023-07-17 2023-09-08 江苏恰瑞生物科技有限公司 一种血液灌流器用改性聚苯乙烯吸附树脂及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
논문 1: Toxicology
논문 2: Fundam. Appl. Toxicol.
논문 3: J. Vet. Med. Sci.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101735415B1 (ko) 2015-07-31 2017-05-16 한국과학기술연구원 헥산알 노출 특이적 메틸화 마커 유전자 및 이를 이용한 확인 방법
KR20230064006A (ko) 2021-11-01 2023-05-10 동국대학교 산학협력단 페놀 노출 여부 평가용 바이오마커 및 이를 이용한 페놀 노출 여부 평가 방법

Also Published As

Publication number Publication date
KR20090090083A (ko) 2009-08-25

Similar Documents

Publication Publication Date Title
KR100985090B1 (ko) 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
KR101134029B1 (ko) 인체 독성 유발 약물 탐색용 마커유전자 및 이를 이용한 탐색 방법
US20110190156A1 (en) Molecular signatures for diagnosing scleroderma
KR101008385B1 (ko) 다환 방향족 탄화수소류 노출 여부 확인용 바이오마커 및이를 이용한 확인 방법
KR100968762B1 (ko) 나프탈렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
KR100994996B1 (ko) 페난트렌 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
KR101342035B1 (ko) 신장독성 및 부작용 유발 약물 검색용 바이오마커 및 이를이용한 신장독성 및 부작용 유발 약물 검색 방법
KR100967546B1 (ko) 벤조에이안트라센 노출 여부 확인용 바이오마커 및 이를이용한 확인 방법
KR100961487B1 (ko) 다이벤조에이에이취안트라센 노출 여부 확인용 바이오마커및 이를 이용한 확인 방법
KR100957055B1 (ko) 트리클로로에틸렌 노출 여부 확인용 바이오마커 및 이를이용한 확인 방법
KR102101807B1 (ko) 인슐린 저항성 진단용 조성물 및 이의 용도
KR100958545B1 (ko) 벤조케이플루오란텐 노출 여부 확인용 바이오마커 및 이를이용한 확인 방법
KR101749566B1 (ko) 디젤 배기 미립자(diesel exhaust particle) 노출에 따른 염증반응 관련 유전자 발현 여부 확인용 바이오마커 및 이를 이용한 확인 방법
Verner et al. Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation
KR101018788B1 (ko) 클로르덴 노출 여부 확인용 바이오마커 및 이를 이용한 확인방법
KR100974228B1 (ko) 최기형성 및 부작용 유발 약물 검색용 바이오마커 및 이를이용한 최기형성 및 부작용 유발 약물 검색 방법
KR100936286B1 (ko) 아미오다론 처리에 따른, 폐독성 유발 약물 검색용마커유전자 및 이를 이용한 검색 방법
KR101011155B1 (ko) 아미오다론 및 카르바마제핀 처리에 따른, 폐독성 유발약물 검색용 마커유전자 및 이를 이용한 검색 방법
KR100915898B1 (ko) ３―메틸콜란트렌 노출 여부 진단용 바이오마커 및 이를이용한 진단 방법
KR101108694B1 (ko) 메토트렉세이트 처리에 따른, 최기형성 유발 약물 검색용바이오마커 및 이를 이용한 검색 방법
US20140066324A1 (en) Gene expression signature in skin predicts response to mycophenolate mofetil
KR20100094705A (ko) 톡사펜 노출 여부 확인용 바이오마커 및 이를 이용한 확인방법
KR100978791B1 (ko) 디클로로메탄 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법
KR101386075B1 (ko) 헥사클로로벤젠 노출 여부 확인용 바이오마커 및 이를 이용한 확인방법
KR20210049684A (ko) 피막형 여포변이 갑상선 유두암과 유두암종유사핵모양비침습소포종양 분류용 조성물 및 이를 이용한 분류 방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E90F Notification of reason for final refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20130628

Year of fee payment: 4

FPAY Annual fee payment

Payment date: 20140701

Year of fee payment: 5

FPAY Annual fee payment

Payment date: 20150630

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee