KR20090121842A - 크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 - Google Patents
크라이센 노출 여부 확인용 바이오마커 및 이를 이용한확인 방법 Download PDFInfo
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Abstract
본 발명은 크라이센(chrysene)에 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것으로, 구체적으로 크라이센에 의해 특이적으로 유전자 발현이 증가 또는 감소하는 바이오마커 및 이를 이용한 크라이센에 대한 노출 여부를 확인하는 방법에 관한 것이며, 본 발명의 바이오마커는 DNA 마이크로어레이 칩을 통하여 선별된 반응 유전자들을 바이오마커로 이용하여 환경 시료에서 크라이센의 오염을 모니터링 및 판정하는데 유용하게 사용될 수 있으며, 크라이센에 의해 유발되는 독성 작용 기작을 규명하는 도구로 이용될 수 있다.
크라이센, 다환 방향족 탄화수소, 바이오마커, 마이크로어레이
Description
본 발명은 크라이센(chrysene)에 대한 노출 여부 확인용 바이오마커 및 이를 이용한 확인 방법에 관한 것이다.
다환 방향족 탄화수소류 중의 하나인 크라이센은 불완전 연소로 인해 환경 중으로 배출되며, 주로 유기물 합성이나 화학적 연구목적으로 사용돼서, 상업적으로는 생산하지 않고 있다. 크라이센의 환경 중 동태를 살펴보면, 휘발성이 없어서 토양 중 이동성이 아주 미미하며, 수중에서는 저질과 부유물질에 흡착하여 물표면 중 휘발성도 거의 없다. 토양보다 물에서 미생물의 분해속도가 늦으며, 토양 중 흡착은 미생물의 분해를 저해하는 것으로 알려져 있다. 또한 환경 중에서 가수분해반응은 일어나지 않으며 수생생물 중 생물농축이 아주 낮다. 대기 중에서는 대부분 입자 상태로만 존재하고 있어 주로 물리적인 방법으로 제거될 수 있다.
환경부(1997) 조사에 의하면 국내 대기 및 지하상가에서의 크라이센 농도 조사에서 서울주택가의 경우 1.80 ng/m3, 대전 태평동의 경우 1.2 ng/m3로 검출되었다. 또한 식품 중 다환방향족 탄화수소류의 오염도 조사연구에서 전국 9개 도시에서 유통되는 육류 가공품의 크라이센의 함량을 조사한 결과 훈연제품 0.176 ㎍/㎏, 가금류 식품 0.842 ㎍/㎏, 육류에서 0.143 ㎍/㎏으로 검출되었고(김명철 등, 식품의약품안전청 2001년도 내분비계 장애물질 연구보고서, 2001), 식용유지에서 평균 0.82 ㎍/㎏으로 조사되었다(이종옥 등, 식품의약품안전청 연구보고서 제6권, 790. 2002).
동물실험에서 크라이센은 경구를 통하여 흡수되고, 피부를 통한 흡수는 매우 느리며, 흡수된 대부분은 분변으로 배출되는 것으로 보고되고 있다[ASTDR(Agency for Toxic Substance and Disease Registry), 1990). 또한 크라이센은 효소에 의하여 디하이드로다이올(dihydrodiols)로 변환되며 더 나아가 다이올-에폭사이드(diol-epoxide)로 대사되어 DNA와 결합체를 형성할 수 있고 DNA 부산물을 형성할 수 있다. 크라이센의 다이올-에폭사이드 유도체들이 발암성 및 돌연변이원성을 일으키는 것으로 보고되어지고 있으며, 살모넬라 TA100과 TA 98균주를 이용한 Ames 실험에서 래트(rat) 간의 대사활성 존재 하에서 돌연변이원성을 나타냈다[HSDB(Hazardous Substance Data bank)].
다환방향족 탄화수소류의 발암성 정도와 유전자 발현 변화에 대한 연구는 일 부 보고되고 있지만, 대표적인 다환방향족 탄화수로류로 알려진 벤조에이파이렌(Benzo[a]pyrene)에 대한 연구에 거의 국한되어 있다. 이처럼 크라이센의 인간에 대한 발암 가능성에도 인체에서의 위해도 평가 데이터가 충분하지 않고, 노출에 대한 검색 방법 역시 GC-MS(Gas Chromatography-Mass Spectrometer) 또는 HPLC(High Performance Liquid Chromatography) 등의 고전적인 방법에 국한되어 있다. GC-MS 또는 HPLC 방법 등을 이용하면 정량은 가능하나 분석을 위한 적정 조건을 설정하여야 하며 고가의 장비 등이 필요하다. 그러므로 더욱 빠르고 간편한 스크리닝(screening) 방법, 예를 들면 프라이머(primer)를 이용하는 실시간 PCR(Real-time reverse transcript polymerase chain reaction) 또는 DNA 마이크로어레이 칩 등으로 신속한 위해성 평가를 통해 인체에서의 독성작용을 탐색할 수 있는 분자적 지표를 발굴하고 활용하여 크라이센의 노출에 대한 적절한 대책 및 관리를 수행하는 것이 중요한 과제라 하겠다.
포유류 6종, 미생물 292종 등 여러 종의 게놈(genome) 염기서열 프로젝트가 완성되어 NCBI(National Center for Biotechnology Information)에 보고되었다. 이렇게 얻어진 막대한 양의 데이터를 기본으로 유전자의 기능을 연구하기 위하여 게놈-와이드 익스프레션(genome-wide expression) 연구가 이루어지고 있다. 한 번의 실험으로 수천 개의 유전자의 발현을 분석하기 위하여 DNA 마이크로어레이(microarray) 분석을 수행한다(Schena M et al., Proc . Natl . Acad . Sci . USA 93:10614-10619, 1996).
마이크로어레이는 cDNA(complementary DNA)나 20 - 25 염기쌍(base pair) 길이의 올리고뉴클레오티드(oligonucleotide)들의 세트를 유리에 집적화한 것이다. cDNA 마이크로어레이는 학교 내의 연구실 또는 Agilent, Genomic Solutions 등의 회사에서 칩 위에 cDNA 수집물을 기계적으로 고정화하거나 잉크젯(ink jetting) 방법을 이용하여 생산하고 있다(Sellheyer K et. al., J. Am . Acad . Dermatol. 51:681-692, 2004). 올리고뉴클레오티드 마이크로어레이는 Affymetrix사에서 사진 식각 공정(photolithography)을 이용하여 칩 위에서 직접 합성하는 방법에 의해 만들어지고 있으며, Agillent사 등에는 합성된 올리고뉴클레오티드를 고정화하는 방법으로 생산하고 있다(Sellheyer K et al ., J. Am . Acad . Dermatol. 51:681-692, 2004).
유전자의 발현을 분석을 위해서는 조직 등 시료에서 RNA를 얻어 DNA 마이크로어레이에 있는 올리고뉴클레오티드와 교잡반응을 수행한다. 얻어진 RNA는 형광이나 동위원소로 표지화하며 cDNA로 전환한다. 올리고 마이크로어레이는 주로 두 개의 다른 형광(예: Cye3 및 Cye5)으로 대조군과 실험군을 각각 표지화하여 같은 칩 상에서 동시에 교잡 반응을 수행한 후 광학적으로 이미지를 스캔하여 형광의 세기를 얻고 그 결과를 분석한다. 두 개의 형광 세기의 비율에 따라 유전자의 발현 여부를 결정한다(Somasundaram K et al ., Genomics Proteomics I:1-10, 2002).
최근 DNA 마이크로어레이 기술을 이용한 첨단 기법인 독성 유전체 학(Toxicogenomics) 연구 등과 접목하여 대량(high throughput)으로 의약품 및 신약 후보물질은 물론 대표적인 환경오염물질을 비롯한 모든 화학물질에 의한 특정 조직이나 세포주에서 발현되는 유전자들의 발현 패턴의 분석, 양적 분석이 가능해졌다. 이에 따라 특정 세포 내에서 특정 유전자의 발현 빈도를 분석함으로써 약물의 부작용 및 환경오염물질의 유해작용과 관련된 유전자의 발굴이 가능하며, 이를 통하여 환경오염물질의 유해작용과 약물의 작용 및 부작용에 따른 분자적 메커니즘을 이해하게 될 것이며 나아가 독성 및 부작용을 유발하는 물질의 검색 및 확인할 수 있게 될 것이다.
이에 본 발명자들은 인간 유전자 4만 4천 개가 집적된 올리고마이크로어레이를 이용하여 크라이센의 유전자 발현 프로파일을 인간 간암 세포인 HepG2 세포주에서 관찰 및 분석함으로써 크라이센에 의해 과발현 또는 저발현 되는 유전자를 발굴하고, 실시간(real-time) RT-PCR 방법에 의해 상기 유전자들의 발현 양상을 확인함으로써 크라이센 노출을 검출할 수 있는 바이오마커 및 이를 이용한 노출 여부를 확인하는 방법을 확립하여 본 발명을 완성하였다.
본 발명의 목적은 크라이센(chrysene)의 노출에 의해 과발현 또는 저발현되는 바이오마커를 제공하는 것이다.
본 발명의 다른 목적은 상기 바이오마커를 이용한 크라이센에 대한 노출 여부를 확인하는 방법을 제공하는 것이다.
본 발명의 다른 목적은 상기 바이오마커를 증폭할 수 있는 프라이머를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공하는 것이다.
상기 목적을 달성하기 위하여, 본 발명은 크라이센(chrysene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 바이오마커를 제공한다.
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 이의 상보가닥 올리고뉴클레오티드가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.
또한, 본 발명은 상기 바이오마커를 이용한 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다.
아울러, 본 발명은 크라이센에 대한 노출 여부 확인용 검색 키트를 제공한다.
이하, 본 발명을 상세히 설명한다.
본 발명은 크라이센(chrysene)의 노출에 의해 발현 변화를 일으키는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 바이오마커를 제공한다.
상기 바이오마커는 2배 이상 발현이 증가 또는 감소한 유전자로써, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자로 구성되어 있다.
본 발명은 하기와 같이 구성된 군에서 선택돼는 것을 특징으로 하는 바이오마커를 제공한다:
유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen- activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번 호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전 자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록 번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번 호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록 번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y- like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번 호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage- gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
1) 상기 바이오마커 중에서 크라이센의 노출에 의해 발현이 증가하는 바이오마커 유전자는 하기와 같다:
유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha- ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807(APLP1, Amyloid beta(A4) precursor-like protein 1), 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등 록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록 번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen,(lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble(opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번 호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12- hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번 호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번 호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5) 및 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo).
2) 상기 바이오마커 중에서, 크라이센의 노출에 의해 발현이 감소하는 바이오마커 유전자는 하기와 같다:
유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유 전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983(SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번 호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번 호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번 호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번 호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135(DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번 호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유 전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
본 발명자들은 크라이센에 대한 노출 여부 확인용 바이오마커를 발굴하기 위하여, 크라이센을 인간 간암 세포주(HepG2)에 처리하여 세포 독성을 확인하였다. 그 결과, 상기 크라이센은 인간 간암 세포주에 독성을 가짐이 확인되었고(도 1 참조), 상기 실험을 바탕으로 80%의 세포생존율(IC20)을 보이는 크라이센의 농도를 결정하였다. 이후 상기 결정된 농도로 크라이센을 인간 간암 세포주에 처리하고, 상기 물질을 처리한 세포주에서 mRNA를 분리하여 cDNA를 합성하면서 형광물질(Cy5)로 표지하였으며, 약물을 처리하지 않은 대조군의 경우 Cy3로 표지하였다. 상기 형광표지된 cDNA를 44 k 올리고마이크로어레이 칩 Human whole genome microarray(Agilent, USA)와 혼성화 하였고, 형광 이미지를 스캔하여 유전자 발현 양상의 차이를 분석하였다(도 2 참조). 분석시 Cy5/Cy3 비율이 2.0배 이상인 경우 발현 증가된 유전자로 분류하였고, 0.5배 이하인 경우 발현 감소된 유전자로 분류하였다. 분석 결과, 발현 증가된 유전자는 0.73%(44,000개의 유전자 중 323개), 발현이 감소된 유전자는 0.82%(44,000개의 유전자 중 361개)임을 확인하였다. 이때, 크라이센에 의해 2배 이상 과발현 또는 저발현 되는 유전자들을 분류한 기능별로 분류하면, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자들이었다(표 2 및 표 3참조). 상기 유전자들은 본 발명에서 사용한 크라이센을 처리했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.
본 발명자들은 상기 유전자 중 과발현된 유전자 25종과 저발현된 유전자 10종을 분리하여 상기 유전자들을 증폭할 있는 프라이머(표 4 참조)를 설계하여, 실시간 RT-PCR(real-time reverse transcript polymerase chain reaction) 방법으로 발현 양상을 조사하였다. 그 결과, 25종의 과발현 유전자들과 10종의 저발현 유전자의 발현 양상이 올리고마이크로어레이 칩 결과와 유사하게 나타남을 확인하였다(표 5 참조). 이들 유전자들은 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_004881(Tumor protein p53 inducible protein 3), 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_006426(Dihydropyrimidinase-like 4), 유전자 등록번호(Genebank) NM_133493[CD109 antigen(Gov platelet alloantigens)], 유전자 등록번호(Genebank) AB033073(Sulfatase 2), 유전자 등록번호(Genebank) NM_021603(FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AK097009(phospholipid transfer protein), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) BU587578(Regulator of G-protein signalling 10), 유전자 등록번호(Genebank) BQ683841[S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) NM_001013632[polo-like kinase 3(Drosophila)], 유전자 등록번호(Genebank) NM_032872(Synaptotagmin-like 1), 유전자 등록번호(Genebank) BC042390[Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000596(Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_005319(Histone 1, H1c), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769[CD9 antigen(p24)], 유전자 등록번호(Genebank) NM_001553(Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410[MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa) 및 유전자 등록번호(Genebank) BC022255[Spindle pole body component 25 homolog(S. cerevisiae)] 등이다.
또한, 본 발명은 상기 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 그의 상보 가닥 분자가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩을 제공한다.
상기 올리고 뉴클레오티드 또는 이의 상보가닥 올리고뉴클레오티드는 상기 바이오마커 유전자의 18 내지 30개의 핵산을 포함하고, 바람직하게는 20 내지 25개의 핵산을 포함한다.
본 발명의 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩은 당업자에게 알려진 방법으로 제작할 수 있다. 상기 마이크로어레이 칩을 제작하는 방법은 하기와 같다. 상기 탐색된 바이오마커를 탐침 DNA 분자로 이용하여 DNA 칩의 기판상에 고정화시키기 위해 파이조일렉트릭(piezoelectric) 방식을 이용한 마이크로파이펫팅(micropipetting)법 또는 핀(pin) 형태의 스폿터(spotter)를 이용한 방법 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니다. 상기 DNA 마이크로어레이 칩의 기판은 아미노-실란(amino-silane), 폴리-L-라이신(poly-L-lysine) 및 알데히드(aldehyde)로 이루어진 군에서 선택되는 하나의 활성기가 코팅된 것이 바람직하나 이에 한정되는 것은 아니다. 또한, 상기 기판은 슬라이드 글래스, 플라스틱, 금속, 실리콘, 나일론 막, 및 니트로셀룰로스 막(nitrocellulose membrane)으로 이루어진 군에서 선택될 수 있으나 이에 제한되는 것은 아니다.
또한, 본 발명은 상기 바이오마커를 이용한 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다.
본 발명은 하기와 같은 과정을 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;
2) 단계 1)의 실험군과 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질을 표지하는 단계;
3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 본 발명의 DNA 마이크로어레이칩과 혼성화 시키는 단계;
4) 단계 3)의 반응한 DNA 마이크로어레이 칩을 분석하는 단계; 및
5) 단계 4)의 분석한 데이터에서 본 발명의 바이오마커의 발현 정도를 대조군과 비교하여 확인하는 단계.
상기 바이오마커를 검출하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다. 이때, 상기 피검체는 크라이센에 노출된 것이 의심되는 개체이고, 대조군은 건강한 인간 개체일 것이다.
상기 바이오마커를 검출하는 방법에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 형광물질은 모두 사용 가능하다.
상기 바이오마커를 검출하는 방법에 있어서, 단계 4)의 DNA 마이크로어레이 칩은 Whole Human Genome Oligo Microarray(Agilent, USA) 등을 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간 게놈 중 본 발명에서 상기 과발현 또는 저발현 유전자(표 2 및 표 3 참조)가 탑재된 마이크로어레이 칩이라면 사용 가능하고, 상기 본 발명자가 제작한 DNA 마이크로어레이 칩을 사용하는 것이 가장 바람직하다. 또한, 단계 4)의 분석 방법은 GenePix 4.1 소프트웨어(Axon Instruments, USA)를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 당업자에게 알려진 분석 소프트웨어를 사용하여도 무방하다.
또한, 본 발명은 하기와 같은 과정을 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 상기 바이오마커를 검출하는 방법을 제공한다:
1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;
2) 단계 1)의 RNA를 대상으로, 본 발명의 바이오마커 유전자에 상보적이고 바이오마커 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및
3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계.
상기 바이오마커를 검출하는 방법에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포를 사용하는 것이 바람직하며, 인간 간암 세포주(HepG2)를 사용하는 것이 더욱 바람직하나 이에 한정되는 것은 아니다. 이때, 상기 피검체는 크라이센에 노출된 것이 의심되는 개체이고, 대조군은 건강한 인간 개체일 것이다.
상기 바이오마커를 검출하는 방법에 있어서, 단계 2)의 프라이머는 본 발명에서 탐색된 바이오마커 유전자와 상보적이고, 바이오마커를 증폭할 수 있는 프라이머라면 모두 사용가능하다. 본 발명에서는 서열번호 1 내지 70으로 기재되는 정방향 및 역방향의 프라이머 35쌍을 제시하였으나 이에 한정되는 것은 아니다.
또한, 본 발명은 크라이센에 대한 노출 여부 확인용 키트를 제공한다.
본 발명은 상기 본 발명에서 제작한 DNA 마이크로어레이 칩을 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다.
상기 확인용 키트에 추가적으로 인간 간세포를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다. 상기 인간 간세포는 HepG2를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 인간의 간 또는 간암의 세포 및 조직에서 유 래한 세포라면 모두 사용 가능하다.
상기 키트에 추가적으로 형광물질을 포함할 수 있으며, 상기 형광물질은 스트렙아비딘-알칼리 탈인화효소 접합물질(strepavidin-like phosphatease conjugate), 화학형광물질(chemiflurorensce) 및 화학발광물질(chemiluminescent)로 이루어진 군으로부터 선택되는 것이 바람직하나 이에 한정되는 것은 아니며, 본 발명의 바람직한 실시예에서는 Cy3와 Cy5를 사용하였다.
상기 키트에 추가적으로 반응 시약을 포함시킬 수 있으며, 상기 반응 시약은 혼성화에 사용되는 완충용액, RNA로부터 cDNA를 합성하기 위한 역전사효소, cNTPs 및 rNTP(사전 혼합형 또는 분리 공급형), 형광 염색제의 화학적 유도제와 같은 표식시약, 세척 완충용액 등으로 구성될 수 있으나 이에 한정된 것은 아니며, 당업자에게 알려진 DNA 마이크로어레이 칩의 혼성화 반응에 필요한 반응 시약은 모두 포함시킬 수 있다.
아울러, 본 발명은 상기 바이오마커 유전자에 상보적이고, 바이오마커 유전자를 증폭할 수 있는 프라이머를 포함하는 크라이센에 대한 노출 여부 확인용 키트를 제공한다.
상기 확인용 키트의 프라이머는 서열번호 1 내지 70으로 기재되는 서열로 구성된 군으로부터 선택되는 2개 이상의 정방향 및 역방향의 프라이머를 사용하는 것이 바람직하나 이에 한정되는 것은 아니며, 상기 바이오마커 유전자에 상보적이며, 바이오마커 유전자를 증폭할 수 있으며 증폭 산물이 100 내지 300 bp가 되도록 설 계된 정방향 및 역방향 프라이머쌍은 모두 사용 가능하다.
본 발명은 크라이센에 노출되었을 때에 특이적으로 발현이 증가 또는 감소되는 DNA 단편을 크라이센에 노출 여부 확인용 바이오마커로 이용하여 크라이센의 모니터링 및 위해성을 판정하는데 유용하며, 크라이센에 의해 야기되는 독성 작용 기작을 규명하는 도구로 이용할 수 있다.
이하, 본 발명을 실시예에 의해 상세히 설명한다.
단, 하기 실시예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 하기 실시예에 한정되는 것은 아니다.
<실시예 1> 세포 배양 및 화학물질 처리
<1-1> 세포배양
인간 간암 세포주인 HepG2 세포(한국 세포주 은행)를 10% FBS가 첨가된 DMEM 배지(Gibro-BRL, USA)를 이용하여 100 ㎜ 디쉬(dish)에서 80% 정도 자랄 때까지 배양하였다. 본 발명자들은 기존의 연구와 보고를 통해 다환방향족 탄화수소류의 하나로서 발암성이 있는 물질인 크라이센(Sigma-Aldrich, USA)을 선정하였으며, DMSO에 용해시켰다. 매질(vehicle) 농도는 모든 실험에서 0.1% 이하였다.
<1-2> 세포 독성 실험(MTT assay) 및 화학 물질 처리
Mossman 등(J. Immunol. Methods, 65, 55-63, 1983)의 방법으로 HepG2 세포주를 이용한 MTT 실험을 수행하였다. 세포는 24-웰 플레이트에 4× 105/웰 세포수로 DMEM 배지(Gibro-BRL, USA)에서 DMSO에 용해된 크라이센을 처리하고 48시간 후에 MTT(3-4,5-dimethylthiazol-2,5-diphenyltetra zolium bromide) 5 ㎎/㎖을 혼합하여 튜브에 가하여 37℃에서 3 시간 동안 배양하였다. 이 후 배지를 제거하고 형성된 포르마잔 크리스탈(formazan crystal)을 DMSO 500 ㎕에 용해하였다. 96-웰 플레이트로 옮겨 분주(aliquot)하고 흡광도 540 ㎚에서 O.D.값을 측정하였다.
HepG2 세포주에서 크라이센의 세포독성을 살펴본 결과, 80% 세포생존율을 보이는 농도(IC20)는 34.97 μM 이었으며(도 1), 상기 농도들로 결정하여 마이크로어레이 실험을 수행하였다.
<실시예 2> 마이크로어레이 실험
<2-1> 표적 RNA의 분리 및 형광 물질 표지
6 × 106 cell/㎖ 농도로 100 ㎜ 디쉬에 HepG2 세포를 분주한 후, 실시예 1-2에서 결정된 크라이센의 농도를 48 시간 동안 처리하였다. 이후, 상기 처리한 세포에서 트리졸(trizol) 시약(Invitrogen life technologies, USA)을 사용하여 제조사의 방법대로 전체 RNA를 분리하고, RNeasy mini kit(Qiagen, USA)를 사용하여 정 제하였다. 게놈 DNA는 RNA 정제 동안 RNase-free DNase set(Qiagen, USA)를 사용하여 제거하였다. 각 전체 RNA 시료의 양은 분광광도계로 측정하였고, 농도는 Agilent 2100 Bioanalyzer(Agilent Technologies, USA)와 아가로스 젤 전기영동으로 확인하였다.
<2-2> 표지된 cDNA 제조
올리고 마이크로어레이 분석을 위하여 실시예 2-1에서 수득한 크라이센 처리군의 전체 RNA를 사용하여 cDNA를 제조하였다. 상기 수득한 전체 RNA 30 ㎍과 올리고(dT) 프라이머 2 ㎍(1 ㎍/㎕)과 혼합하고 65℃에서 10분간 반응시킨 후 바로 얼음에 넣어 어닐링(annealing)시켰다. 상기 어닐링된 RNA의 역전사(Reverse Transcript) 반응을 위해 표 1과 같이 시약을 혼합하였다.
구성 | 부피(㎕) |
5X first strand buffer | 6 |
dNTPs | 0.6 |
0.1 M DDT | 3 |
SuperScript II enzyme | 3 |
Cy-3 or Cy-5 dUTP | 2 |
대조군인 HepG2 세포주에서 분리한 전체 RNA는 Cy3-dUTP(녹색)로 표지화 하였고, 크라이센을 처리한 HepG2 세포주로부터 분리한 RNA는 Cy5-dUTP(적색)로 표지화 하였다. 이때 두 시료는 Microcon YM-30 컬럼(Millipore, USA)을 사용하여 혼합, 정제되었다.
<2-3> 혼성화 반응
혼성화 및 세척 과정은 지노첵(주)의 지시방법에 따라 수행되었다. 혼성화는 12시간 동안 62℃ 오븐에서 수행되었다. DNA 마이크로어레이 칩으로는 44 k Whole Human Genome Oligo Microarray(Agilent, USA)를 이용하였다. 세척(2분간 2× SSC/0.1% SDS에 세척, 3분간 1× SSC, 2분간 0.2× SSC에 세척) 후 슬라이드는 3분간 800 rpm으로 원심분리 하여 건조하였다.
<2-4> 형광 이미지 획득
슬라이드 상의 혼성화 이미지는 Genepix 4000B(Axon Instruments, USA)로 스캔하였다. 결합하지 않은 유전자를 세척한 칩은 레이저 광 스캐너(laser fluorescence scanner)를 사용하여 형광 이미지를 획득하였다. 이때 녹색 형광 이미지는 대조군에서, 적색 형광 이미지는 실험군에서만 특이하게 발현되는 유전자의 활성정도를 나타내게 되며, 노란색 형광 이미지는 녹색과 적색의 보색으로 두 군의 발현이 큰 차이가 없음을 의미한다. 스캔한 이미지들은 유전자 발현 비율을 얻기 위하여 GenePix 4.1 소프트웨어(Axon Instruments, USA)로 분석하였다(도 2). 이렇게 하여 얻어진 데이터로부터 크라이센에 대한 마커 유전자를 선별하였다.
그 결과, 올리고 칩 상에 존재하는 대략 4만 4천 개의 유전자 중에서 크라이센에 의해 Cy5/Cy3의 비율이 2.0배 이상으로 유전자 발현 증가를 보이는 유전자는 0.73%(44,000개의 유전자 중 323개) 발현이 감소된 유전자는 0.82%(44,000개의 유전자 중 361개)임을 확인하였다.
이때, 크라이센에 의해 2배 이상 과발현 혹은 저발현 되는 유전자들을 기능별로 분류한 결과, MAPKinase 신호 경로(MAPKinase Signaling Pathway), MAPKKK 캐스케이드(MAPKKK cascade), p53 신호 경로(p53 Signaling Pathway), 아팝토시스(apoptosis), DNA 손상 반응(response to DNA damage stimulus), 스트레스에 대한 반응(Response to stress), 면역반응(immune response), 세포 주기(cell cycle), 유사분열 세포주기(Mitotic cell cycle), 세포 분화(Cell differentiation), 세포 성장(Cell growth), 세포 증식(cell proliferation), 알코올 대사(Alcohol metabolism), DNA 대사(DNA metabolism), 지질 대사(lipid metabolism), 아미노산 대사(Amino acid metabolism), 금속원소 결합(metal binding) 및 전달(Transport) 등에 관련된 유전자로 분류되었다(표 2 및 3). 상기 유전자들은 본 발명에서 사용한 크라이센을 처리 했을 때, 인간 간암 세포에서 독성과 관련이 있다는 보고는 없다.
등록번호 | 유전자약어 | 유전자명 | 중간값의비 |
(a) MAPKinase 신호 경로(MAPKinase Signaling Pathway) | |||
NM_003954 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | 2.642090915 |
AB209586 | MAPK13 | Mitogen-activated protein kinase 13 | 2.32604791 |
NM_005343 | HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog | 2.300183763 |
BX647104 | FOS | V-fos FBJ murine osteosarcoma viral oncogene homolog | 2.286644731 |
NM_007315 | STAT1 | Signal transducer and activator of transcription 1, 91kDa | 2.268249473 |
BC027933 | MAPK11 | Mitogen-activated protein kinase 11 | 2.256117014 |
NM_020529 | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 2.242341043 |
BC014966 | RPS6KA1 | Ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.109933874 |
(b) p53 신호 경로(p53 Signaling Pathway) | |||
NM_181861 | APAF1 | Apoptotic peptidase activating factor | 2.323610287 |
L41870 | RB1 | Retinoblastoma 1 (including osteosarcoma) | 2.431277919 |
CR612719 | GADD45A | Growth arrest and DNA-damage-inducible, alpha | 2.785095956 |
BM462208 | PCNA | Proliferating cell nuclear antigen | 5.94704061 |
M92424 | MDM2 | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse) | 4.056640879 |
NM_078467 | CDKN1A | Cyclin-dependent kinase inhibitor 1A(p21, Cip1) | 21.05152341 |
(c) 아팝토시스(Apoptosis) | |||
BC089389 | IHPK3 | Inositol hexaphosphate kinase 3 | 17.86623375 |
NM_001024807 | APLP1 | Amyloid beta(A4) precursor-like protein 1 | 14.60038469 |
NM_001013398 | IGFBP3 | Insulin-like growth factor binding protein 3 | 11.51469533 |
AB209361 | FAS | Fas(TNF receptor superfamily, member 6) | 9.282797498 |
NM_147780 | CTSB | Cathepsin B | 6.625352723 |
NM_001165 | BIRC3 | Baculoviral IAP repeat-containing 3 | 6.105445052 |
BM557864 | HSPB1 | Heat shock 27kDa protein 1 | 5.988972006 |
AB033060 | PDCD6 | Aryl-hydrocarbon receptor repressor | 5.709323333 |
AK125880 | TP53INP1 | Tumor protein p53 inducible nuclear protein 1 | 4.730741529 |
NM_004574 | 04-Sep | Septin 4 | 4.420718644 |
NM_003820 | TNFRSF14 | Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator) | 4.241834154 |
CN478604 | LGALS7 | Lectin, galactoside-binding, soluble, 7(galectin 7) | 4.215529017 |
NM_004879 | EI24 | Etoposide induced 2.4 mRNA | 3.840012717 |
NM_003311 | PHLDA2 | Pleckstrin homology-like domain, family A, member 2 | 3.66045378 |
NM_003897 | IER3 | Immediate early response 3 | 3.323689948 |
AK097284 | TNFAIP8 | Tumor necrosis factor, alpha-induced protein 8 | 3.301416171 |
NM_000582 | SPP1 | Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 3.007301243 |
NM_013258 | PYCARD | PYD and CARD domain containing | 2.704730239 |
NM_002305 | LGALS1 | Lectin, galactoside-binding, soluble, 1(galectin 1) | 2.685571797 |
AF055634 | UNC5C | Unc-5 homolog C(C. elegans) | 2.64453651 |
CR614015 | CD14 | CD14 antigen | 2.620138457 |
AK129595 | GADD45B | Growth arrest and DNA-damage-inducible, beta | 2.431892144 |
AF356193 | CARD6 | Caspase recruitment domain family, member 6 | 2.315498432 |
BC063043 | PRF1 | Perforin 1(pore forming protein) | 2.300936607 |
BX537586 | STK17A | Serine/threonine kinase 17a(apoptosis-inducing) | 2.173582084 |
NM_003842 | TNFRSF10B | Tumor necrosis factor receptor superfamily, member 10b | 2.164540104 |
AF208043 | IFI16 | Interferon, gamma-inducible protein 16 | 2.147368247 |
BX641114 | ANXA4 | Annexin A4 | 2.143018533 |
NM_001009552 | PPP2CB | Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 2.132316431 |
BX386171 | CGB5 | Chorionic gonadotropin, beta polypeptide 8 | 2.11678504 |
AY358103 | HIP1 | Huntingtin interacting protein 1 | 2.101135287 |
BC027949 | P2RX1 | Purinergic receptor P2X, ligand-gated ion channel, 1 | 2.093924251 |
BC042844 | CASP10 | Caspase 10, apoptosis-related cysteine peptidase | 2.071460864 |
NM_000733 | CD3E | CD3E antigen, epsilon polypeptide(TiT3 complex) | 2.069295152 |
NM_033245 | PML | Promyelocytic leukemia | 2.031289487 |
BC047362 | PHLDA1 | Pleckstrin homology-like domain, family A, member 1 | 2.030766246 |
(d) DNA 손상에 대한 반응(Response to DNA damage stimulus) | |||
NM_006763 | BTG2 | BTG family, member 2 | 8.033431013 |
BC050455 | DDB2 | LIM homeobox 3 | 5.130890941 |
BC068535 | TP53AP1 | TP53 activated protein 1 | 3.847202974 |
AF033122 | SESN1 | Sestrin 1 | 3.728462177 |
AB024313 | POLH | Polymerase(DNA directed), eta | 3.515123881 |
NM_001012716 | TYMS | Thymidylate synthetase | 3.123891212 |
BC095402 | ATXN3 | Ataxin 3 | 2.201860506 |
BU675073 | PTTG1 | Pituitary tumor-transforming 1 | 2.178628404 |
BC073161 | RAD51C | RAD51 homolog C(S. cerevisiae) | 2.092699518 |
NM_001983 | ERCC1 | Excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | 1.811298942 |
(e) 스트레스에 대한 반응(Response to stress) | |||
NM_018965 | TREM2 | Triggering receptor expressed on myeloid cells 2 | 43.66510076 |
BX649164 | PAI; PAI1; PAI-1; PLANH1 | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 | 29.04597327 |
NM_006404 | PROCR | Protein C receptor, endothelial(EPCR) | 24.52788989 |
BC035582 | TRIM22 | Tripartite motif-containing 22 | 13.78919459 |
NM_006691 | XLKD1 | Extracellular link domain containing 1 | 10.05591814 |
NM_015831 | ACHE | Acetylcholinesterase (YT blood group) | 6.223349052 |
BC045666 | TP53I11 | Tumor protein p53 inducible protein 11 | 6.007745545 |
NM_005438 | FOSL1 | FOS-like antigen 1 | 5.642502876 |
NM_005755 | EBI3 | Epstein-Barr virus induced gene 3 | 5.606891978 |
BM918324 | LY96 | Lymphocyte antigen 96 | 5.438550593 |
NM_000022 | ADA | Adenosine deaminase | 5.212717207 |
NM_004167 | CCL14 | Chemokine(C-C motif) ligand 15 | 5.102559642 |
NM_014278 | HSPA4L | Heat shock 70kDa protein 4-like | 4.710398517 |
BC006523 | SGK2 | Serum/glucocorticoid regulated kinase 2 | 4.64953324 |
NM_000641 | IL11 | Interleukin 11 | 4.520629217 |
H18681 | C20orf139 | Sulfiredoxin 1 homolog(S. cerevisiae) | 4.383369833 |
NM_001769 | CD9 | CD9 antigen(p24) | 4.153073307 |
BG564326 | SAA4 | Serum amyloid A4, constitutive | 4.075835655 |
NM_016816 | OAS1 | 2',5'-oligoadenylate synthetase 1, 40/46kDa | 3.710610826 |
CB055213 | ICOSLG | Inducible T-cell co-stimulator ligand | 3.643779829 |
CR591007 | CCL3 | Chemokine(C-C motif) ligand 3 | 3.346884519 |
NM_145641 | APOL3 | Apolipoprotein L, 3 | 3.195513004 |
AK127663 | PTGES | Prostaglandin E synthase | 3.183821649 |
NM_001734 | C1S | Complement component 1, s subcomponent | 3.018342133 |
NM_002260 | KLRC3 | Killer cell lectin-like receptor subfamily C, member 2 | 2.941895363 |
NM_001733 | C1R | Complement component 1, r subcomponent | 2.893399755 |
AB209922 | DNAJB4 | DnaJ(Hsp40) homolog, subfamily B, member 4 | 2.872000914 |
NM_201397 | GPX1 | Glutathione peroxidase 1 | 2.850015447 |
AK090482 | CXCL12 | Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1) | 2.842225911 |
BF662985 | CCL3L1 | Chemokine(C-C motif) ligand 3-like 1 | 2.838582233 |
NM_001779 | CD58 | CD58 antigen, (lymphocyte function-associated antigen 3) | 2.794341637 |
NM_005064 | CCL23 | Chemokine(C-C motif) ligand 23 | 2.761400386 |
NM_000242 | MBL2 | Mannose-binding lectin(protein C) 2, soluble(opsonic defect) | 2.755428358 |
NM_032036 | FAM14A | Family with sequence similarity 14, member A | 2.706203775 |
AJ890082 | HSPCA | Heat shock 90kDa protein 1, alpha | 2.54395008 |
BC068487 | TLR3 | Toll-like receptor 3 | 2.540522037 |
NM_000552 | VWF | Von Willebrand factor | 2.476094941 |
NM_000132 | F8 | Coagulation factor VIII, procoagulant component(hemophilia A) | 2.414521007 |
AY154461 | NALP6 | NACHT, leucine rich repeat and PYD containing 6 | 2.392028958 |
AK127679 | DUSP1 | Dual specificity phosphatase 1 | 2.382519952 |
NM_014314 | DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 2.333495418 |
NM_000311 | PRNP | Prion protein (p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | 2.313144503 |
NM_006597 | HSPA8 | Heat shock 70kDa protein 8 | 2.313144445 |
AK092040 | ZCSL2 | Zinc finger, CSL-type containing 2 | 2.303019345 |
NM_031483 | ITCH | Itchy homolog E3 ubiquitin protein ligase(mouse) | 2.300924118 |
U25029 | NR3C1 | Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor) | 2.273770608 |
NM_005242 | F2RL1 | Coagulation factor II (thrombin) receptor-like 1 | 2.25765938 |
AK172851 | ADORA2B | Adenosine A2b receptor | 2.248876245 |
BQ053419 | BATF | Basic leucine zipper transcription factor, ATF-like | 2.220924757 |
BC020698 | CCL20 | Chemokine(C-C motif) ligand 20 | 2.199037915 |
NM_001124 | ADM | Adrenomedullin | 2.186497254 |
NM_153609 | TMPRSS6 | Transmembrane protease, serine 6 | 2.118468174 |
NM_004148 | NINJ1 | Ninjurin 1 | 2.106988819 |
AF324224 | APOL2 | Apolipoprotein L, 2 | 2.105247356 |
BC040494 | DNAJB2 | DnaJ(Hsp40) homolog, subfamily B, member 2 | 2.053186934 |
BE512691 | GPX2 | Glutathione peroxidase 2(gastrointestinal) | 2.014366573 |
NM_001002029 | C4A | Complement component 4B, telomeric | 2.002292152 |
(f) 면역 반응(Immune response) | |||
NM_000732 | CD3D | CD3D antigen, delta polypeptide(TiT3 complex) | 54.93792815 |
AK223210 | CD79B | CD79B antigen (immunoglobulin-associated beta) | 15.33023863 |
NM_002309 | LIF | Hypothetical protein MGC20647 | 8.088491848 |
AF031469 | MR1 | Major histocompatibility complex, class I-related | 7.058743082 |
NM_172208 | TAPBP | TAP binding protein (tapasin) | 7.020261414 |
BC021117 | CSF1 | Colony stimulating factor 1(macrophage) | 4.788017417 |
NM_001421 | ELF4 | E74-like factor 4 (ets domain transcription factor) | 4.315617246 |
NM_002119 | HLA-DOA | Major histocompatibility complex, class II, DO alpha | 4.208814419 |
BX648013 | TAP1 | Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP) | 4.079915559 |
AL832287 | ZAP70 | Zeta-chain(TCR) associated protein kinase 70kDa | 3.830282261 |
BF569086 | NK4 | Interleukin 32 | 3.137700229 |
AL832451 | DKFZp451C2311 | guanylate binding protein 2, interferon-inducible | 2.638811674 |
AF069493 | SEMA7A | Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A | 2.530855422 |
NM_001008490 | KLF6 | Kruppel-like factor 6 | 2.300245668 |
NM_000418 | IL4R | Interleukin 4 receptor | 2.254471504 |
NM_004048 | B2M | Beta-2-microglobulin | 2.006239064 |
(g) 세포 주기(Cell cycle) | |||
AF116720 | DNAJA2 | DnaJ(Hsp40) homolog, subfamily A, member 2 | 10.94418029 |
NM_001007271 | DUSP13 | Dual specificity phosphatase 13 | 7.030871577 |
BM904612 | S100A6 | S100 calcium binding protein A6(calcyclin) | 5.937525522 |
AK074652 | SERTAD1 | SERTA domain containing 1 | 4.83549333 |
NM_203394 | E2F7 | E2F transcription factor 7 | 3.647469222 |
NM_003620 | PPM1D | Protein phosphatase 1D magnesium-dependent, delta isoform | 3.646783838 |
BC060797 | PARD6G | Par-6 partitioning defective 6 homolog gamma(C. elegans) | 3.501662527 |
NM_021913 | AXL | AXL receptor tyrosine kinase | 3.268484061 |
BC040303 | PTP4A1 | Protein tyrosine phosphatase type IVA, member 1 | 3.182840665 |
BC008564 | PPP1R9B | Protein phosphatase 1, regulatory subunit 9B, spinophilin | 3.169099614 |
AK097024 | RAE1 | RAE1 RNA export 1 homolog(S. pombe) | 2.920923726 |
BC011957 | BTG3 | BTG family, member 3 | 2.73961999 |
NM_078487 | CDKN2B | Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4) | 2.55897751 |
BC023552 | SFN | Stratifin | 2.524571283 |
BC060847 | PARD6B | Par-6 partitioning defective 6 homolog beta(C. elegans) | 2.507221799 |
NM_003236 | TGFA | Transforming growth factor, alpha | 2.487048846 |
NM_002632 | PGF | Placental growth factor, vascular endothelial growth factor-related protein | 2.435909331 |
NM_015278 | SASH1 | SAM and SH3 domain containing 1 | 2.368157793 |
AL834276 | MGC3207 | Hypothetical protein MGC3207 | 2.364392455 |
AK096276 | CCND3 | Cyclin D3 | 2.291774022 |
AB209373 | CCNK | Chromosome 14 open reading frame 65 | 2.27376643 |
NM_021132 | PPP3CB | Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform(calcineurin A beta) | 2.19575961 |
NM_005072 | SLC12A4 | Solute carrier family 12(potassium/chloride transporters), member 4 | 2.184117922 |
BX647886 | PCNP | SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae) | 2.132837165 |
NM_044472 | CDC42 | Cell division cycle 42(GTP binding protein, 25kDa) | 2.08723035 |
AL832973 | REC8L1 | REC8-like 1(yeast) | 2.050105112 |
NM_002031 | FRK | Fyn-related kinase | 2.008244265 |
(h) 세포 분화(Cell differentiation) | |||
BM913048 | TIMP1 | TIMP metallopeptidase inhibitor 1 | 14.51811118 |
NM_003975 | SH2D2A | SH2 domain protein 2A | 6.609387012 |
NM_198129 | LAMA3 | Laminin, alpha 3 | 6.313840426 |
NM_006152 | LRMP | Lymphoid-restricted membrane protein | 3.452878243 |
X96753 | CSPG4 | Chondroitin sulfate proteoglycan 4(melanoma-associated) | 3.342871665 |
NM_000474 | TWIST1 | Twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila) | 2.962045566 |
AF052152 | DCAMKL1 | Doublecortin and CaM kinase-like 1 | 2.946594775 |
AF333334 | CCIN | Calicin | 2.907611782 |
NM_005979 | S100A13 | S100 calcium binding protein A13 | 2.38786608 |
NM_004429 | EFNB1 | Ephrin-B1 | 2.290394007 |
NM_003873 | NRP1 | Neuropilin 1 | 2.102000337 |
AF026692 | SFRP4 | Secreted frizzled-related protein 4 | 2.097767188 |
AK124583 | DAZAP1 | DAZ associated protein 1 | 2.09304534 |
AF003837 | JAG1 | Jagged 1(Alagille syndrome) | 2.052565745 |
AB209590 | BMP1 | Bone morphogenetic protein 1 | 2.018231591 |
(i) 세포 성장(Cell growth) | |||
X54457 | CEL | Carboxyl ester lipase (bile salt-stimulated lipase) | 11.0110822 |
Y11307 | CYR61 | Cysteine-rich, angiogenic inducer, 61 | 8.870510533 |
NM_000596 | IGFBP1 | Insulin-like growth factor binding protein 1 | 4.426373693 |
NM_020997 | LEFTY1 | Left-right determination factor 1 | 4.011782013 |
NM_001553 | IGFBP7 | Insulin-like growth factor binding protein 7 | 3.467233091 |
AB209509 | IGFBP2 | Insulin-like growth factor binding protein 2, 36kDa | 2.280688594 |
NM_001552 | IGFBP4 | Insulin-like growth factor binding protein 4 | 2.170002081 |
AB209321 | CSRP2 | Cysteine and glycine-rich protein 2 | 2.079139635 |
BM556279 | EMP3 | Epithelial membrane protein 3 | 2.029076597 |
(j) 세포 증식(Cell proliferation) | |||
NM_005727 | TSPAN1 | Tetraspanin 1 | 8.454659213 |
BQ683841 | S100A11 | S100 calcium binding protein A11(calgizzarin) | 6.064178076 |
BC042390 | VTI1B | Vesicle transport through interaction with t-SNAREs homolog 1B(yeast) | 4.485613104 |
NM_000899 | KITLG | KIT ligand | 3.751569954 |
BC032940 | LAMP3 | Lysosomal-associated membrane protein 3 | 2.728811271 |
BQ939577 | AKR1C3 | Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II) | 2.683290824 |
BC063468 | OSMR | Oncostatin M receptor | 2.652841837 |
CR936719 | SSR1 | Signal sequence receptor, alpha(translocon-associated protein alpha) | 2.559482267 |
AB024057 | TBC1D8 | TBC1 domain family, member 8(with GRAM domain) | 2.53463919 |
NM_003329 | TXN | Thioredoxin | 2.324939817 |
NM_012125 | CHRM5 | Cholinergic receptor, muscarinic 5 | 2.112618735 |
NM_007045 | FGFR1OP | FGFR1 oncogene partner | 2.09430482 |
(k) 알코올 대사(Alcohol metabolism) | |||
AK094474 | RHOC | Ras homolog gene family, member C | 4.227972245 |
BC017706 | 6PGL | 6-phosphogluconolactonase | 2.621428387 |
AF153821 | ADH1B | Alcohol dehydrogenase IB(class I), beta polypeptide | 2.420867965 |
AK124656 | ENO2 | Enolase 2(gamma, neuronal) | 2.273190922 |
D42047 | GPD1L | Glycerol-3-phosphate dehydrogenase 1-like | 2.170305169 |
AK130060 | TALDO1 | Transaldolase 1 | 2.107113338 |
AL833069 | KIAA1434 | Hypothetical protein KIAA1434 | 2.042123428 |
XM_496436 | UNQ6077 | C219-reactive peptide | 2.011483091 |
NM_199186 | BPGM | 2,3-bisphosphoglycerate mutase | 2.001621684 |
(l) DNA 대사(DNA metabolism) | |||
U86136 | TEP1 | Telomerase-associated protein 1 | 5.354849784 |
BU603483 | HIST1H1E | Histone 1, H1e | 4.639090453 |
NM_005319 | HIST1H1C | Histone 1, H1c | 4.25715277 |
NM_005320 | HIST1H1D | Histone 1, H1d | 3.30127345 |
NM_003516 | HIST2H2AA | Histone 2, H2aa | 3.052311773 |
F02250 | HDAC2 | Histone deacetylase 2 | 2.559211106 |
NM_004739 | MTA2 | Metastasis associated 1 family, member 2 | 2.439100864 |
BC042589 | HIST1H2BD | Histone 1, H2bd | 2.361377538 |
CB529694 | HIST2H2BE | Histone 2, H2be | 2.358417445 |
AK126154 | NP | Nucleoside phosphorylase | 2.252382538 |
AB040899 | KIAA1466 | KIAA1466 gene | 2.150614231 |
CR608156 | HIST1H2AC | Histone 1, H2ac | 1.894716468 |
BX436525 | HIST1H2BH | Histone 1, H2bh | 1.564280897 |
(m) 지질 대사(Lipid metabolism) | |||
AK057762 | TDH | L-threonine dehydrogenase | 12.35436994 |
BC035124 | UNQ2541 | MSFL2541 | 11.28144368 |
BC034763 | FDXR | Ferredoxin reductase | 9.626878353 |
AK093461 | ISYNA1 | Myo-inositol 1-phosphate synthase A1 | 8.506076027 |
AK097009 | PLTP | phospholipid transfer protein | 6.838113748 |
AF524864 | AKR1B10 | Aldo-keto reductase family 1, member B10(aldose reductase) | 5.170205623 |
NM_021727 | FADS3 | Fatty acid desaturase 3 | 4.914325733 |
CR627415 | HSD3B2 | Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 | 3.576157214 |
CD013987 | CYP21A2 | Cytochrome P450, family 21, subfamily A, polypeptide 2 | 3.499529399 |
BC020744 | AKR1C4 | Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 3.073709856 |
NM_004753 | DHRS3 | Dehydrogenase/reductase (SDR family) member 3 | 2.952592956 |
BC030207 | NR0B2 | Nuclear receptor subfamily 0, group B, member 2 | 2.923794075 |
AK091948 | LTB4DH | Leukotriene B4 12-hydroxydehydrogenase | 2.915047859 |
NM_002900 | RBP3 | Retinol binding protein 3, interstitial | 2.882318017 |
BX647927 | PLCD1 | Phospholipase C, delta 1 | 2.79125248 |
NM_145323 | OSBPL3 | Oxysterol binding protein-like 3 | 2.683653218 |
NM_000169 | GLA | Galactosidase, alpha | 2.640805113 |
BC094756 | CRA | Myotubularin related protein 11 | 2.621196547 |
AB043587 | ACBD3 | Acyl-Coenzyme A binding domain containing 3 | 2.387297906 |
NM_001478 | GALGT | UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T) | 2.371502969 |
J05428 | UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 | 2.29241428 |
AB002454 | CYP4F3 | Cytochrome P450, family 4, subfamily F, polypeptide 3 | 2.282463636 |
NM_000405 | GM2A | GM2 ganglioside activator | 2.078054404 |
BC001823 | PRKAB1 | Protein kinase, AMP-activated, beta 1 non-catalytic subunit | 2.069992917 |
NM_145343 | APOL1 | Apolipoprotein L, 1 | 2.065071129 |
NM_006571 | DCTN6 | Dynactin 6 | 2.032649122 |
NM_020139 | DHRS6 | Dehydrogenase/reductase (SDR family) member 6 | 2.017235349 |
(n) 금속 결합(Metal-binding) | |||
NM_000499 | CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 88.34463354 |
BC007003 | TGM4 | Transglutaminase 4 (prostate) | 24.06656282 |
NM_012189 | CABYR | Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2) | 15.7546354 |
CR615530 | CYGB | Cytoglobin | 5.509895512 |
NM_004199 | P4HA2 | Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II | 4.763879118 |
AK027560 | CYP26A1 | Cytochrome P450, family 26, subfamily A, polypeptide 1 | 4.292062656 |
NM_145298 | APOBEC3F | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F | 4.282991592 |
NM_005576 | LOXL1 | Lysyl oxidase-like 1 | 3.991893457 |
AK024854 | APOBEC3B | Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative) | 3.958267305 |
NM_014301 | NIFUN | NifU-like N-terminal domain containing | 3.922562485 |
BF670653 | MB | Myoglobin | 3.907590399 |
AK126982 | LHX6 | LIM homeobox 6 | 3.753938819 |
Y13786 | ADAM19 | ADAM metallopeptidase domain 19(meltrin beta) | 3.418775374 |
AB051455 | MICAL-L1 | MICAL-like 1 | 3.221168592 |
AK074068 | MICAL-L2 | MICAL-like 2 | 3.121829223 |
AK124421 | CPA1 | Carboxypeptidase A1 (pancreatic) | 3.111462293 |
NM_030622 | CYP2S1 | Cytochrome P450, family 2, subfamily S, polypeptide 1 | 2.768815748 |
BC012027 | CYP2U1 | Cytochrome P450, family 2, subfamily U, polypeptide 1 | 2.36896757 |
AY461717 | ZNF385 | Zinc finger protein 385 | 20.23244477 |
AK092424 | ZSCAN4 | Zinc finger and SCAN domain containing 4 | 17.62610589 |
AB208935 | RASAL1 | RAS protein activator like 1(GAP1 like) | 13.22811232 |
NM_201444 | DGKA | Diacylglycerol kinase, alpha 80kDa | 6.831831283 |
BC035625 | EGR2 | Early growth response 2(Krox-20 homolog, Drosophila) | 5.012409534 |
BF983391 | RPS27L | Ribosomal protein S27-like | 4.896252688 |
BC036545 | PLAC2 | Placenta-specific 2 | 4.739700637 |
BC034569 | ZNF337 | Zinc finger protein 337 | 4.082511332 |
CR936707 | TRIM38 | Tripartite motif-containing 38 | 3.756338118 |
AK091940 | MGC4734 | Ring finger protein 183 | 3.644058609 |
NM_024101 | MLPH | Melanophilin | 3.369249376 |
CR601823 | HIVEP3 | Human immunodeficiency virus type I enhancer binding protein 3 | 3.290777497 |
BC041578 | MGC17986 | zinc finger protein 114 | 3.166948191 |
BC038432 | RARA | Retinoic acid receptor, alpha | 2.87080107 |
(o) 전달(Transport) | |||
BX641053 | FXYD2 | FXYD domain containing ion transport regulator 2 | 14.84364998 |
AK095363 | AQP3 | Aquaporin 3 | 8.623096731 |
AK074100 | SLC37A2 | Solute carrier family 37(glycerol-3-phosphate transporter), member 2 | 8.471999196 |
AK024002 | TUBA4 | Tubulin, alpha 4 | 7.427767363 |
AK092677 | TUBB6 | Tubulin, beta 6 | 6.458458484 |
NM_001297 | CNGB1 | Cyclic nucleotide gated channel beta 1 | 5.653120818 |
NM_032872 | SYTL1 | Synaptotagmin-like 1 | 4.930987441 |
NM_014045 | LRP10 | Low density lipoprotein receptor-related protein 10 | 4.616793009 |
NM_014585 | SLC40A1 | Solute carrier family 40(iron-regulated transporter), member 1 | 4.60980312 |
L02870 | COL7A1 | Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive) | 4.294284493 |
AK054731 | TUBA1 | Tubulin, alpha 1 (testis specific) | 4.193322321 |
AF336127 | SLC4A11 | Solute carrier family 4, sodium bicarbonate transporter-like, member 11 | 4.116663762 |
AB075951 | SLC22A2 | Solute carrier family 22(organic cation transporter), member 2 | 3.98434766 |
AK125026 | SLC6A12 | Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12 | 3.756467829 |
BX537541 | MGC13186 | Chromosome 1 open reading frame 57 | 3.712498811 |
CD013956 | SHBG | Sex hormone-binding globulin | 3.685973664 |
BC029057 | DAO | D-amino-acid oxidase | 3.657991139 |
BC041479 | COL9A2 | Collagen, type IX, alpha 2 | 3.573628765 |
AL050210 | LOC283130 | Hypothetical protein LOC283130 | 3.265255922 |
NM_004798 | KIF3B | Kinesin family member 3B | 3.214670618 |
AK025742 | UCP2 | Uncoupling protein 2 (mitochondrial, proton carrier) | 3.187327318 |
NM_021990 | GABRE | Gamma-aminobutyric acid(GABA) A receptor, epsilon | 3.110885736 |
NM_005819 | STX6 | Syntaxin 6 | 3.089406302 |
BC092420 | CYP4F11 | Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129) | 3.048152378 |
BC043423 | ABCB6 | ATP-binding cassette, sub-family B(MDR/TAP), member 6 | 3.039132233 |
BC021025 | CTHRC1 | Collagen triple helix repeat containing 1 | 3.022775957 |
NM_004999 | MYO6 | Myosin VI | 3.020625421 |
AF445025 | SLC35A4 | Solute carrier family 35, member A4 | 3.018853063 |
NM_003330 | TXNRD1 | Thioredoxin reductase 1 | 2.810879753 |
AK092512 | SLC16A5 | Solute carrier family 16(monocarboxylic acid transporters), member 5 | 2.5780312 |
AB075871 | FLJ42654 | Golgi transport 1 homolog A(S. cerevisiae) | 2.278893633 |
(p) 기타(The others) | |||
NM_004864 | GDF15 | Growth differentiation factor 15 | 6.654247181 |
NM_022153 | PP2135 | Chromosome 10 open reading frame 54 | 6.333855415 |
NM_001013632 | LOC343521 | Similar to hypothetical protein 4833401D15 | 5.344247617 |
AK124751 | CAPN2 | Calpain 2,(m/II) large subunit | 4.877328363 |
AK095079 | RGC32 | Response gene to complement 32 | 3.2942944 |
NM_031286 | SH3BGRL3 | SH3 domain binding glutamic acid-rich protein like 3 | 2.915143493 |
AK126182 | KIAA1949 | KIAA1949 | 2.807348634 |
NM_080388 | S100A16 | S100 calcium binding protein A16 | 2.607982075 |
NM_025106 | SSB1 | SplA/ryanodine receptor domain and SOCS box containing 1 | 2.522542864 |
NM_203403 | C9orf150 | Chromosome 9 open reading frame 150 | 2.200130419 |
AK096241 | SQSTM1 | Sequestosome 1 | 2.015574807 |
BQ276852 | TMSB10 | Thymosin, beta 10 | 1.863965907 |
BC101655 | HIST1H2BI | Histone 1, H2bi | 1.863164701 |
W84524 | TM4SF5 | Transmembrane 4 L six family member 5 | 1.768210846 |
BX647290 | HIST1H2BO | Histone 1, H2bo | 1.511861325 |
등록번호 | 유전자약어 | 유전자명 | 중간값의비 |
(a) MAPKinase 신호 경로(MAPKinase Signaling Pathway) | |||
NM_002467 | MYC | V-myc myelocytomatosis viral oncogene homolog(avian) | 0.153957027 |
BC038295 | MAP2K7 | Mitogen-activated protein kinase kinase 7 | 0.250015644 |
NM_004364 | CEBPA | CCAAT/enhancer binding protein(C/EBP), alpha | 0.291022284 |
NM_145161 | MAP2K5 | Mitogen-activated protein kinase kinase 5 | 0.396692291 |
XM_042066 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | 0.424190161 |
Z25424 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.440953544 |
AB209047 | ELK1 | ELK1, member of ETS oncogene family | 0.46931591 |
NM_004755 | RPS6KA5 | Ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.486533941 |
AB001872 | RPL4 | Mitogen-activated protein kinase kinase kinase 13 | 0.488828813 |
NM_002758 | MAP2K6 | Mitogen-activated protein kinase kinase 6 | 0.489648933 |
AK098095 | BRAF | V-raf murine sarcoma viral oncogene homolog B1 | 0.490796917 |
(b) MAPKKK 캐스케이드(MAPKKK cascade) | |||
AB208919 | FGFR1 | Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome) | 0.306072231 |
BC060837 | DUSP9 | Dual specificity phosphatase 9 | 0.309017123 |
NM_000142 | FGFR3 | Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism) | 0.316732251 |
AY247738 | TRIB3 | Tribbles homolog 3 (Drosophila) | 0.319013779 |
NM_030640 | DUSP16 | Dual specificity phosphatase 16 | 0.346335506 |
NM_148957 | TNFRSF19 | Tumor necrosis factor receptor superfamily, member 19 | 0.373948519 |
AB011123 | TNIK | TRAF2 and NCK interacting kinase | 0.375429687 |
NM_006549 | CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2, beta | 0.375436076 |
NM_022740 | HIPK2 | Homeodomain interacting protein kinase 2 | 0.491170791 |
(c) 아팝토시스(Apoptosis) | |||
NM_005400 | PRKCE | Protein kinase C, epsilon | 0.110495908 |
NM_000893 | KNG1 | Kininogen 1 | 0.123179781 |
NM_000066 | C8B | Complement component 8, beta polypeptide | 0.168259363 |
CR749293 | PLG | Plasminogen | 0.214468702 |
BC013780 | ADORA2A | Adenosine A2a receptor | 0.25462881 |
NM_001012271 | BIRC5 | Effector cell peptidase receptor 1 | 0.261340346 |
NM_003811 | TNFSF9 | Tumor necrosis factor (ligand) superfamily, member 9 | 0.278995394 |
BC050369 | E2F1 | E2F transcription factor 1 | 0.284336508 |
NM_007313 | ABL1 | V-abl Abelson murine leukemia viral oncogene homolog 1 | 0.286557271 |
BX647151 | MYBL2 | V-myb myeloblastosis viral oncogene homolog(avian)-like 2 | 0.292335923 |
NM_004822 | NTN1 | Netrin 1 | 0.298168066 |
BC033694 | BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.334908167 |
AB208876 | AXIN1 | Axin 1 | 0.346768268 |
BC051332 | F2 | Coagulation factor II (thrombin) | 0.347828025 |
AK122614 | PPARD | Peroxisome proliferative activated receptor, delta | 0.348064401 |
L78790 | ITGB2 | Integrin, beta 2 (antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit) | 0.377717722 |
AK223409 | BARD1 | BRCA1 associated RING domain 1 | 0.385577392 |
NM_002737 | PRKCA | Protein kinase C, alpha | 0.38570547 |
NM_012479 | YWHAG | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | 0.38743105 |
CR596268 | ITGB3BP | Integrin beta 3 binding protein(beta3-endonexin) | 0.392340911 |
NM_003551 | NME5 | Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase) | 0.397002326 |
NM_013974 | DDAH2 | Dimethylarginine dimethylaminohydrolase 2 | 0.397010628 |
D79987 | ESPL1 | Extra spindle poles like 1(S. cerevisiae) | 0.397660686 |
NM_006427 | SIVA | CD27-binding(Siva) protein | 0.399556277 |
NM_024900 | PHF17 | PHD finger protein 17 | 0.400845508 |
AB046854 | MAGI-3 | Membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.423418754 |
AK095578 | SPHK1 | Sphingosine kinase 1 | 0.442516388 |
AK122762 | CIDEA | Cell death-inducing DFFA-like effector a | 0.448550433 |
AK092872 | ERCC2 | Excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D) | 0.448557114 |
NM_006290 | TNFAIP3 | Tumor necrosis factor, alpha-induced protein 3 | 0.452157996 |
NM_000562 | C8A | Complement component 8, alpha polypeptide | 0.463461593 |
AK122894 | AKT1 | V-akt murine thymoma viral oncogene homolog 1 | 0.467334939 |
NM_005067 | SIAH2 | Seven in absentia homolog 2(Drosophila) | 0.467840694 |
NM_203339 | CLU | Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) | 0.469884724 |
NM_003376 | VEGF | Vascular endothelial growth factor | 0.481416264 |
AK027590 | DAPK3 | Death-associated protein kinase 3 | 0.48390449 |
AK122825 | HMGB1 | High-mobility group box 1 | 0.505043422 |
(d) DNA 손상에 대한 반응(Response to DNA damage stimulus) | |||
NM_006904 | PRKDC | Protein kinase, DNA-activated, catalytic polypeptide | 0.136872821 |
AK074377 | UHRF1 | Chromosome 19 open reading frame 31 | 0.162554272 |
CR604810 | CCNA2 | Cyclin A2 | 0.271739971 |
AK001720 | FLJ10858 | Nei endonuclease VIII-like 3(E. coli) | 0.272320034 |
CR600021 | HMGB2 | High-mobility group box 2 | 0.292500615 |
NM_006230 | POLD2 | Polymerase(DNA directed), delta 2, regulatory subunit 50kDa | 0.296598073 |
NM_018151 | RIF1 | RAP1 interacting factor homolog(yeast) | 0.337901829 |
BX248766 | RAD51L1 | RAD51-like 1(S. cerevisiae) | 0.35239904 |
NM_014502 | PRP19 | PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae) | 0.352412499 |
NM_013975 | LIG3 | Ligase III, DNA, ATP-dependent | 0.366235708 |
NM_173627 | FLJ35220 | Hypothetical protein FLJ35220 | 0.370187726 |
NM_003362 | UNG | Uracil-DNA glycosylase | 0.378408018 |
AF076494 | IRF7 | Interferon regulatory factor 7 | 0.385612995 |
CR625391 | RAD51AP1 | RAD51 associated protein 1 | 0.391222632 |
NM_006231 | POLE | Polymerase(DNA directed), epsilon | 0.394826988 |
NM_130398 | EXO1 | Exonuclease 1 | 0.407524268 |
DQ140356 | KIAA1596 | Fanconi anemia, complementation group M | 0.412353616 |
NM_002105 | H2AFX | H2A histone family, member X | 0.41455303 |
AB209560 | POLD1 | Polymerase(DNA directed), delta 1, catalytic subunit 125kDa | 0.443656469 |
NM_000136 | FANCC | Fanconi anemia, complementation group C | 0.444998791 |
NM_003368 | USP1 | Ubiquitin specific peptidase 1 | 0.445903079 |
NM_022836 | DCLRE1B | DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae) | 0.446832858 |
NM_001067 | TOP2A | Topoisomerase(DNA) II alpha 170kDa | 0.450120675 |
NM_002913 | RFC1 | Replication factor C (activator 1) 1, 145kDa | 0.471937101 |
NM_002412 | MGMT | O-6-methylguanine-DNA methyltransferase | 0.492152777 |
NM_000251 | MSH2 | MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli) | 0.582053356 |
(e) 면역 반응(Immune response) | |||
NM_015254 | KIF13B | Kinesin family member 13B | 0.20677975 |
NM_006037 | HDAC4 | Histone deacetylase 4 | 0.233288586 |
NM_020995 | HPR | Haptoglobin-related protein | 0.242867738 |
NM_153443 | KIR3DL1 | Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 | 0.281426014 |
BC071718 | CCL4L1 | Chemokine(C-C motif) ligand 4-like 1 | 0.294604522 |
NM_020979 | APS | Adaptor protein with pleckstrin homology and src homology 2 domains | 0.29487541 |
NM_001629 | ALOX5AP | Arachidonate 5-lipoxygenase-activating protein | 0.300419669 |
NM_130852 | PLUNC | Palate, lung and nasal epithelium carcinoma associated | 0.320441751 |
AK024499 | SPON2 | Spondin 2, extracellular matrix protein | 0.328221638 |
BC048198 | AHSG | Alpha-2-HS-glycoprotein | 0.344058212 |
AK095849 | RNU22 | RNA, U22 small nucleolar | 0.353888139 |
BC005395 | HPX | Hemopexin | 0.367891973 |
NM_012276 | ILT7 | Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4 | 0.392427034 |
NM_003152 | STAT5A | Signal transducer and activator of transcription 5A | 0.400291045 |
BC037171 | CCL27 | Chemokine(C-C motif) ligand 27 | 0.40075022 |
NM_002468 | MYD88 | Myeloid differentiation primary response gene(88) | 0.403137375 |
NM_002215 | ITIH1 | Inter-alpha (globulin) inhibitor H1 | 0.405944172 |
NM_004750 | CRLF1 | Cytokine receptor-like factor 1 | 0.413787497 |
DR004094 | HAMP | Hepcidin antimicrobial peptide | 0.413938464 |
BC063245 | GNLY | Granulysin | 0.422712087 |
AJ290445 | SARM1 | Sterile alpha and TIR motif containing 1 | 0.430080233 |
AK122686 | IF | I factor(complement) | 0.436309666 |
AB008535 | GPR44 | G protein-coupled receptor 44 | 0.440552612 |
AK122912 | ZGPAT | Zinc finger, CCCH-type with G patch domain | 0.44067651 |
BC022312 | C4BPA | Complement component 4 binding protein, alpha | 0.442950052 |
BG564683 | ORM1 | Orosomucoid 1 | 0.445506981 |
NM_000625 | NOS2A | Nitric oxide synthase 2A(inducible, hepatocytes) | 0.460550527 |
NM_005515 | HLXB9 | Homeo box HB9 | 0.467040193 |
BX537504 | C2 | Complement component 2 | 0.484853058 |
BC028153 | LILRB3 | Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3 | 0.490534341 |
AF130100 | SERPINC1 | Serpin peptidase inhibitor, clade C(antithrombin), member 1 | 0.491818077 |
BC015110 | HHEX | Hematopoietically expressed homeobox | 0.602852309 |
(f) 유사분열 세포주기(Mitotic cell cycle) | |||
AB209179 | PLK1 | Polo-like kinase 1 (Drosophila) | 0.120946155 |
AY367065 | ASPM | Asp(abnormal spindle)-like, microcephaly associated(Drosophila) | 0.186885667 |
NM_006101 | KNTC2 | Kinetochore associated 2 | 0.257114298 |
NM_003550 | MAD1L1 | MAD1 mitotic arrest deficient-like 1(yeast) | 0.268688634 |
NM_020242 | KNSL7 | Kinesin family member 15 | 0.280736071 |
AB033068 | FZR1 | Fizzy/cell division cycle 20 related 1(Drosophila) | 0.281781782 |
NM_018492 | PBK | PDZ binding kinase | 0.284074566 |
NM_003318 | TTK | TTK protein kinase | 0.3026269 |
BC011000 | CDCA5 | Cell division cycle associated 5 | 0.31212201 |
NM_003981 | PRC1 | Protein regulator of cytokinesis 1 | 0.313872555 |
NM_015097 | CLASP2 | Cytoplasmic linker associated protein 2 | 0.336054596 |
U65410 | MAD2L1 | MAD2 mitotic arrest deficient-like 1(yeast) | 0.34214776 |
NM_016343 | CENPF | Centromere protein F, 350/400ka(mitosin) | 0.344911485 |
NM_005504 | BCAT1 | Branched chain aminotransferase 1, cytosolic | 0.345858236 |
NM_003718 | CDC2L5 | Cell division cycle 2-like 5(cholinesterase-related cell division controller) | 0.354681271 |
NM_002768 | PCOLN3 | Procollagen(type III) N-endopeptidase | 0.389132906 |
BC004352 | KIF22 | Kinesin family member 22 | 0.391492074 |
NM_005983 | SKP2 | S-phase kinase-associated protein 2(p45) | 0.39153455 |
NM_004523 | KIF11 | Kinesin family member 11 | 0.421587881 |
CR592757 | BRRN1 | Barren homolog 1 (Drosophila) | 0.430159766 |
NM_019063 | EML4 | Echinoderm microtubule associated protein like 4 | 0.434736842 |
NM_006845 | KIF2C | Kinesin family member 2C | 0.43971662 |
NM_004701 | CCNB2 | Cyclin B2 | 0.442694391 |
NM_138555 | KIF23 | Kinesin family member 23 | 0.449014129 |
NM_182687 | PKMYT1 | Protein kinase, membrane associated tyrosine/threonine 1 | 0.452437142 |
NM_001790 | CDC25C | Cell division cycle 25C | 0.460379159 |
BC032677 | UBE2C | Ubiquitin-conjugating enzyme E2C | 0.462505602 |
NM_005886 | KATNB1 | Katanin p80(WD repeat containing) subunit B 1 | 0.464765241 |
BC073878 | KIFC1 | Kinesin family member C1 | 0.481322258 |
AL833191 | SMC2L1 | SMC2 structural maintenance of chromosomes 2-like 1(yeast) | 0.486060683 |
AF053305 | BUB1 | BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast) | 0.491236752 |
Z25431 | NEK1 | NIMA(never in mitosis gene a)-related kinase 1 | 0.49168642 |
BC043371 | GFI1B | Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML) | 0.494495314 |
CR933728 | CDC2 | Cell division cycle 2, G1 to S and G2 to M | 0.496459108 |
NM_014750 | DLG7 | Discs, large homolog 7(Drosophila) | 0.580070458 |
(g) 세포 주기(Cell cycle) | |||
NM_018560 | WWOX | WW domain containing oxidoreductase | 0.079825512 |
BG203702 | FHIT | Nasopharyngeal carcinoma, down-regulated 1 | 0.093083555 |
BC050384 | SUPT3H | Suppressor of Ty 3 homolog(S. cerevisiae) | 0.126706068 |
NM_000189 | HK2 | Hexokinase 2 | 0.173385257 |
CD049340 | AURKB | Aurora kinase B | 0.19031938 |
AB011153 | PLCB1 | Phospholipase C, beta 1(phosphoinositide-specific) | 0.215552494 |
AB209271 | ERF | Ets2 repressor factor | 0.232018189 |
NM_014264 | PLK4 | Polo-like kinase 4 (Drosophila) | 0.247388103 |
NM_002417 | MKI67 | Antigen identified by monoclonal antibody Ki-67 | 0.258796008 |
XM_496557 | RGP1 | Plasminogen-like B2 | 0.294326139 |
NM_170715 | RASSF1 | Ras association (RalGDS/AF-6) domain family 1 | 0.298232376 |
NM_004526 | MCM2 | MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae) | 0.302992712 |
BC033086 | TCF19 | Transcription factor 19(SC1) | 0.32373718 |
NM_001007071 | RPS6KB2 | Ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 0.324307585 |
NM_016272 | TOB2 | Transducer of ERBB2, 2 | 0.330193495 |
AK126688 | CDYL2 | Chromodomain protein, Y-like 2 | 0.387113875 |
NM_001759 | CCND2 | Cyclin D2 | 0.389524403 |
NM_002388 | MCM3 | MCM3 minichromosome maintenance deficient 3(S. cerevisiae) | 0.398257469 |
NM_182776 | MCM7 | MCM7 minichromosome maintenance deficient 7(S. cerevisiae) | 0.404714589 |
NM_012145 | DTYMK | Deoxythymidylate kinase(thymidylate kinase) | 0.423208336 |
NM_014751 | MTSS1 | Metastasis suppressor 1 | 0.43748772 |
NM_024342 | GRLF1 | Glucocorticoid receptor DNA binding factor 1 | 0.442555888 |
AK025627 | CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.471323938 |
NM_005915 | MCM6 | MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae) | 0.472089288 |
AF196185 | PARD3 | Par-3 partitioning defective 3 homolog(C. elegans) | 0.484933312 |
NM_019001 | XRN1 | 5'-3' exoribonuclease 1 | 0.488883063 |
NM_006739 | MCM5 | MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae) | 0.491549947 |
NM_012218 | ILF3 | Interleukin enhancer binding factor 3, 90kDa | 0.492503876 |
AB053172 | CDT1 | DNA replication factor | 0.493969454 |
AK074112 | CCNL2 | Cyclin L2 | 0.498469976 |
NM_001005414 | ZWINT | ZW10 interactor antisense | 0.584517014 |
(h) 알코올 대사(Alcohol metabolism) | |||
BC033391 | PP1665 | Glycerophosphodiester phosphodiesterase domain containing 5 | 0.215800503 |
NM_000672 | ADH6 | Alcohol dehydrogenase 6(class V) | 0.271123842 |
NM_004563 | PCK2 | Phosphoenolpyruvate carboxykinase 2(mitochondrial) | 0.337047159 |
XM_113962 | KIAA0650 | Structural maintenance of chromosomes flexible hinge domain containing 1 | 0.348581608 |
NM_001500 | GMDS | GDP-mannose 4,6-dehydratase | 0.354747755 |
NM_002541 | OGDH | Oxoglutarate (alpha-ketoglutarate) dehydrogenase(lipoamide) | 0.357289949 |
NM_000298 | PKLR | Pyruvate kinase, liver and RBC | 0.39231759 |
NM_005276 | GPD1 | Glycerol-3-phosphate dehydrogenase 1(soluble) | 0.394511398 |
AB209127 | PFKL | Phosphofructokinase, liver | 0.396666891 |
M15943 | ADH4 | Alcohol dehydrogenase 4(class II), pi polypeptide | 0.441308466 |
NM_000671 | ADH5 | Alcohol dehydrogenase 5(class III), chi polypeptide | 0.448054959 |
BC026320 | OGDHL | Oxoglutarate dehydrogenase-like | 0.464556343 |
NM_009590 | AOC2 | Amine oxidase, copper containing 2(retina-specific) | 0.479506902 |
BC015797 | SLC25A10 | Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10 | 0.489192347 |
(i) 아미노산 대사(Amino acid metabolism) | |||
NM_003748 | ALDH4A1 | Aldehyde dehydrogenase 4 family, member A1 | 0.179005599 |
NM_002108 | HAL | Histidine ammonia-lyase | 0.19694868 |
NM_003486 | SLC7A5 | Solute carrier family 7(cationic amino acid transporter, y+ system), member 5 | 0.201120723 |
NM_003045 | SLC7A1 | Solute carrier family 7(cationic amino acid transporter, y+ system), member 1 | 0.204215808 |
NM_000277 | PAH | Phenylalanine hydroxylase | 0.207720611 |
NM_012331 | MSRA | Methionine sulfoxide reductase A | 0.21152792 |
BC008366 | DDC | Dopa decarboxylase (aromatic L-amino acid decarboxylase) | 0.219970928 |
NM_006567 | FARS2 | Phenylalanine-tRNA synthetase 2(mitochondrial) | 0.242735735 |
AK055862 | FLJ31300 | Urocanase domain containing 1 | 0.265306391 |
NM_001875 | CPS1 | Carbamoyl-phosphate synthetase 1, mitochondrial | 0.284603831 |
AK122685 | GLUD1 | Glutamate dehydrogenase 1 | 0.290594908 |
NM_003046 | SLC7A2 | Solute carrier family 7(cationic amino acid transporter, y+ system), member 2 | 0.303490377 |
AK093306 | PHGDH | Phosphoglycerate dehydrogenase | 0.315789771 |
NM_080820 | HARS2 | Histidyl-tRNA synthetase 2 | 0.337699715 |
NM_006907 | PYCR1 | Pyrroline-5-carboxylate reductase 1 | 0.343360051 |
NM_020117 | LARS | Leucyl-tRNA synthetase | 0.359457546 |
BC051726 | GLUL | Glutamate-ammonia ligase(glutamine synthetase) | 0.363765571 |
BC012616 | BHMT | Betaine-homocysteine methyltransferase | 0.369989797 |
AK055053 | SHMT2 | Serine hydroxymethyltransferase 2(mitochondrial) | 0.401235464 |
NM_007101 | SARDH | Sarcosine dehydrogenase | 0.402864636 |
AL833251 | LOC283970 | Hypothetical protein LOC283970 | 0.40730291 |
AK027126 | ASS | Argininosuccinate synthetase | 0.418690738 |
L00972 | CBS | Cystathionine-beta-synthase | 0.440354778 |
NM_206965 | FTCD | Formiminotransferase cyclodeaminase | 0.47079397 |
NM_000429 | MAT1A | Methionine adenosyltransferase I, alpha | 0.472559543 |
NM_001801 | CDO1 | Cysteine dioxygenase, type I | 0.480848737 |
NM_006843 | SDS | Serine dehydratase | 0.488304529 |
NM_000170 | GLDC | Glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) | 0.491686799 |
(j) DNA 대사(DNA metabolism) | |||
BX102654 | HIST1H4B | Histone 1, H4b | 0.172360533 |
DQ097177 | UREB1 | HECT, UBA and WWE domain containing 1 | 0.213344474 |
NM_022743 | SMYD3 | SET and MYND domain containing 3 | 0.265102932 |
NM_001809 | CENPA | Centromere protein A, 17kDa | 0.272224677 |
AB028450 | NCOR1 | Nuclear receptor co-repressor 1 | 0.31777205 |
NM_002967 | SAFB | Scaffold attachment factor B | 0.3219512 |
NM_003074 | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.353538227 |
NM_015409 | EP400 | E1A binding protein p400 | 0.371543731 |
BC044659 | SMARCA3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 | 0.393689415 |
AB209433 | BAT8 | Euchromatic histone-lysine N-methyltransferase 2 | 0.398851055 |
XM_370756 | KIAA1305 | KIAA1305 | 0.41059832 |
NM_020201 | NT5M | 5',3'-nucleotidase, mitochondrial | 0.425450039 |
NM_001025248 | DUT | DUTP pyrophosphatase | 0.4301363 |
AK123010 | RRM2 | Ribonucleotide reductase M2 polypeptide | 0.443733966 |
BX537961 | DNMT2 | DNA (cytosine-5-)-methyltransferase 2 | 0.449895729 |
BX648935 | TBL1XR1 | Transducin (beta)-like 1X-linked receptor 1 | 0.45144224 |
NM_001001888 | VCX-C | Variably charged X-C | 0.451813598 |
NM_002501 | NFIX | Nuclear factor I/X (CCAAT-binding transcription factor) | 0.455473267 |
NM_003483 | HMGA2 | High mobility group AT-hook 2 | 0.45812854 |
U80628 | TK2 | Thymidine kinase 2, mitochondrial | 0.460005269 |
NM_006807 | CBX1 | Chromobox homolog 1 (HP1 beta homolog Drosophila ) | 0.46081477 |
AY024361 | MLL3 | Myeloid/lymphoid or mixed-lineage leukemia 3 | 0.461050924 |
NM_017519 | ARID1B | AT rich interactive domain 1B(SWI1-like) | 0.46115551 |
NM_003077 | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.461333882 |
NM_016937 | POLA | Polymerase(DNA directed), alpha | 0.463508595 |
(k) 지질 대사(Lipid metabolism) | |||
AJ007583 | LARGE | Like-glycosyltransferase | 0.142759166 |
AK124635 | PCSK9 | Proprotein convertase subtilisin/kexin type 9 | 0.146781198 |
NM_030758 | OSBP2 | Oxysterol binding protein 2 | 0.148618668 |
NM_005063 | SCD | Stearoyl-CoA desaturase(delta-9-desaturase) | 0.16572839 |
NM_000236 | LIPC | Lipase, hepatic | 0.198492731 |
AF288389 | GLT25D2 | Glycosyltransferase 25 domain containing 2 | 0.198600514 |
AF202889 | APOA5 | Apolipoprotein A-V | 0.209911653 |
BX640945 | FADS2 | Fatty acid desaturase 2 | 0.213145374 |
BI521580 | APOC3 | Apolipoprotein C-III | 0.23320201 |
NM_001277 | CHKA | Choline kinase alpha | 0.244381018 |
Z28339 | AKR1D1 | Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase) | 0.254902416 |
BC035654 | NR1H4 | Nuclear receptor subfamily 1, group H, member 4 | 0.262741172 |
AB209229 | MVD | Mevalonate (diphospho) decarboxylase | 0.269846903 |
BC026264 | UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 | 0.271647964 |
NM_004104 | FASN | Fatty acid synthase | 0.280448461 |
NM_147161 | THEA | Acyl-CoA thioesterase 11 | 0.285998121 |
AF059203 | SOAT2 | Sterol O-acyltransferase 2 | 0.288070163 |
NM_020918 | GPAM | Glycerol-3-phosphate acyltransferase, mitochondrial | 0.292909604 |
NM_001443 | FABP1 | Fatty acid binding protein 1, liver | 0.296451689 |
NM_014762 | DHCR24 | 24-dehydrocholesterol reductase | 0.297972079 |
AK093328 | PCYT2 | Phosphate cytidylyltransferase 2, ethanolamine | 0.311874518 |
BX538214 | C6orf167 | Chromosome 6 open reading frame 167 | 0.323543551 |
X75311 | MVK | Mevalonate kinase (mevalonic aciduria) | 0.333966231 |
NM_000497 | CYP11B1 | Cytochrome P450, family 11, subfamily B, polypeptide 1 | 0.338436304 |
BC036102 | SIAT7F | ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 | 0.34576685 |
BC012172 | ACAS2 | Acyl-CoA synthetase short-chain family member 2 | 0.350569281 |
NM_007169 | PEMT | Phosphatidylethanolamine N-methyltransferase | 0.356048412 |
X91148 | MTP | Microsomal triglyceride transfer protein | 0.362753622 |
NM_198839 | ACACA | Acetyl-Coenzyme A carboxylase alpha | 0.380784496 |
NM_004687 | MTMR4 | Myotubularin related protein 4 | 0.401837935 |
NM_000384 | APOB | Apolipoprotein B (including Ag(x) antigen) | 0.416233282 |
AK127051 | ACAA1 | Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 0.423299321 |
BC035638 | LSS | Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.430665775 |
NM_004204 | PIGQ | Phosphatidylinositol glycan, class Q | 0.45218399 |
NM_004457 | ACSL3 | Acyl-CoA synthetase long-chain family member 3 | 0.454938664 |
AL138578 | ADPN | Adiponutrin | 0.461837251 |
NM_002332 | LRP1 | Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor) | 0.468691544 |
NM_016372 | GPR175 | G protein-coupled receptor 175 | 0.479022743 |
NM_080476 | CDC91L1 | CDC91 cell division cycle 91-like 1(S. cerevisiae) | 0.479354103 |
AF303134 | ALDH8A1 | Aldehyde dehydrogenase 8 family, member A1 | 0.481811965 |
NM_002130 | HMGCS1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble) | 0.483678121 |
AK055414 | LASS4 | LAG1 longevity assurance homolog 4(S. cerevisiae) | 0.485211697 |
NM_022977 | ACSL4 | Acyl-CoA synthetase long-chain family member 4 | 0.485591269 |
NM_004631 | LRP8 | Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | 0.490795611 |
NM_002573 | PAFAH1B3 | Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa | 0.495601801 |
NM_021005 | NR2F2 | Nuclear receptor subfamily 2, group F, member 2 | 0.497299707 |
(l) 금속 결합(Metal-binding) | |||
CR620135 | DPEP1 | Dipeptidase 1(renal) | 0.190430174 |
NM_002317 | LOX | Lysyl oxidase | 0.198239785 |
NM_005949 | MT1F | Metallothionein 1F (functional) | 0.22405551 |
AF279145 | ANTXR1 | Anthrax toxin receptor 1 | 0.230840625 |
NM_005588 | MEP1A | Meprin A, alpha(PABA peptide hydrolase) | 0.259485084 |
NM_014214 | IMPA2 | Inositol(myo)-1(or 4)-monophosphatase 2 | 0.263186701 |
NM_005940 | MMP11 | Matrix metallopeptidase 11(stromelysin 3) | 0.264566247 |
AB193259 | ACE2 | Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2 | 0.273758292 |
AF018081 | COL18A1 | Collagen, type XVIII, alpha 1 | 0.291828069 |
M28016 | cytochrome b | Human mitochondrial cytochrome b gene, partial cds. | 0.297761706 |
NM_002428 | MMP15 | Matrix metallopeptidase 15(membrane-inserted) | 0.31207988 |
NM_025074 | FRAS1 | Fraser syndrome 1 | 0.33237663 |
M75106 | CPB2 | Carboxypeptidase B2 (plasma, carboxypeptidase U) | 0.614512721 |
NM_000937 | POLR2A | Polymerase(RNA) II (DNA directed) polypeptide A, 220kDa | 0.204681289 |
NM_005060 | RORC | RAR-related orphan receptor C | 0.221567885 |
BC092512 | MYRIP | Myosin VIIA and Rab interacting protein | 0.248675106 |
NM_000901 | NR3C2 | Nuclear receptor subfamily 3, group C, member 2 | 0.266066448 |
NM_005392 | PHF2 | PHD finger protein 2 | 0.268831722 |
AK091289 | ZNF367 | Zinc finger protein 367 | 0.275012045 |
NM_014788 | TRIM14 | Tripartite motif-containing 14 | 0.276556442 |
NM_018660 | ZNF395 | Zinc finger protein 395 | 0.296616246 |
AB209755 | MLLT10 | Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10 | 0.300538557 |
AK097472 | MAZ | MYC-associated zinc finger protein(purine-binding transcription factor) | 0.313722345 |
NM_020062 | SLC2A4RG | SLC2A4 regulator | 0.33059257 |
BX571750 | HNF4G | Hepatocyte nuclear factor 4, gamma | 0.332470234 |
(m) 전달(Transport) | |||
NM_021807 | SEC8L1 | Exocyst complex component 4 | 0.089545841 |
NM_006651 | CPLX1 | Complexin 1 | 0.131109907 |
NM_005845 | ABCC4 | ATP-binding cassette, sub-family C(CFTR/MRP), member 4 | 0.133334881 |
NM_006650 | CPLX2 | Complexin 2 | 0.134012051 |
NM_004164 | RBP2 | Retinol binding protein 2, cellular | 0.156673775 |
NM_021069 | ARGBP2 | Sorbin and SH3 domain containing 2 | 0.166678886 |
NM_201649 | SLC6A9 | Solute carrier family 6(neurotransmitter transporter, glycine), member 9 | 0.214191554 |
NM_005835 | SLC17A2 | Solute carrier family 17(sodium phosphate), member 2 | 0.221982855 |
AJ315644 | SLC2A13 | Solute carrier family 2(facilitated glucose transporter), member 13 | 0.222684082 |
NM_000340 | SLC2A2 | Solute carrier family 2(facilitated glucose transporter), member 2 | 0.227123291 |
NM_003685 | KHSRP | KH-type splicing regulatory protein(FUSE binding protein 2) | 0.22945097 |
BX537382 | SLC38A3 | Solute carrier family 38, member 3 | 0.242568721 |
NM_182964 | NAV2 | Neuron navigator 2 | 0.247250994 |
BX640965 | SLC22A3 | Solute carrier family 22(extraneuronal monoamine transporter), member 3 | 0.255608537 |
AK127255 | SNX26 | Sorting nexin 26 | 0.260176313 |
AY043484 | SCN1A | Sodium channel, voltage-gated, type I, alpha | 0.260866507 |
AK074107 | C20orf59 | Chromosome 20 open reading frame 59 | 0.271346073 |
NM_003056 | SLC19A1 | Solute carrier family 19(folate transporter), member 1 | 0.29688016 |
NM_020897 | HCN3 | Hyperpolarization activated cyclic nucleotide-gated potassium channel 3 | 0.313835834 |
AY124771 | SLC26A1 | Solute carrier family 26(sulfate transporter), member 1 | 0.317100952 |
NM_001011554 | SLC13A3 | Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3 | 0.321469735 |
AK027855 | SLC5A6 | Solute carrier family 5(sodium-dependent vitamin transporter), member 6 | 0.327464039 |
NM_001005747 | CACNB4 | Calcium channel, voltage-dependent, beta 4 subunit | 0.332952777 |
NM_013277 | RACGAP1 | Rac GTPase activating protein 1 | 0.378143166 |
(n) 기타(The others) | |||
NM_012340 | NFATC2 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.417449456 |
NM_018291 | FLJ10986 | Hypothetical protein FLJ10986 | 0.181870965 |
BC052951 | LMNB1 | Lamin B1 | 0.197126008 |
AK075271 | SPTLC2L | Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2) | 0.230098147 |
BI762502 | GSTA2 | Glutathione S-transferase A2 | 0.31916011 |
AK055221 | FBXO5 | F-box protein 5 | 0.342113931 |
XM_372695 | LOC390859 | PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA | 0.356013687 |
AB037805 | KLHL14 | Kelch-like 14 (Drosophila) | 0.376251676 |
NM_145061 | C13orf3 | Chromosome 13 open reading frame 3 | 0.377419925 |
AK000643 | ASB9 | Ankyrin repeat and SOCS box-containing 9 | 0.419775956 |
AL133031 | MLR1 | Transcription factor MLR1 | 0.438551394 |
AB091343 | C10orf3 | Centrosomal protein 55kDa | 0.451690933 |
AY007723 | MAL2 | Mal, T-cell differentiation protein 2 | 0.456188931 |
BC098313 | FLJ20641 | Hypothetical protein FLJ20641 | 0.508085568 |
BC041882 | ATF7IP2 | Activating transcription factor 7 interacting protein 2 | 0.521200373 |
AK127098 | FLJ10706 | Chromosome 1 open reading frame 112 | 0.527226934 |
BC022255 | Spc25 | Spindle pole body component 25 homolog(S. cerevisiae) | 0.537391579 |
BC026283 | APOH | Apolipoprotein H (beta-2-glycoprotein I) | 0.650367241 |
<실시예 3> 실시간 RT-PCR(Real-time reverse transcriptase polymerase chain reaction) 정량
크라이센에 의해 발현 유도된 상기 실시예 2의 2배 이상 과발현 및 저발현된 유전자 중 크라이센에 의해 과발현되는 유전자 25종과 저발현 되는 유전자 10종을 선별하였다. 이들 유전자들은 유전자 등록번호(Genebank) NM_000499(Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BX649164(serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_004881(Tumor protein p53 inducible protein 3), 유전자 등록번호(Genebank) BM913048(TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_006426(Dihydropyrimidinase-like 4), 유전자 등록번호(Genebank) NM_133493[CD109 antigen(Gov platelet alloantigens)], 유전자 등록번호(Genebank) AB033073(Sulfatase 2), 유전자 등록번호(Genebank) NM_021603(FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) BC035124(MSFL2541), 유전자 등록번호(Genebank) Y11307(Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) AK095363(Aquaporin 3), 유전자 등록번호(Genebank) AK097009(phospholipid transfer protein), 유전자 등록번호(Genebank) NM_004864(Growth differentiation factor 15), 유전자 등록번호(Genebank) BU587578(Regulator of G-protein signalling 10), 유전자 등록번호(Genebank) BQ683841[S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) NM_001013632[polo-like kinase 3(Drosophila)], 유전자 등록번호(Genebank) NM_032872(Synaptotagmin-like 1), 유전자 등록번호(Genebank) BC042390[Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000596(Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_005319(Histone 1, H1c), 유전자 등록번호(Genebank) AK094474(Ras homolog gene family, member C), 유전자 등록번호(Genebank) NM_001769[CD9 antigen(p24)], 유전자 등록번호(Genebank) NM_001553(Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) NM_003897(Immediate early response 3), 유전자 등록번호(Genebank) NM_003516(Histone 2, H2aa), 유전자 등록번호(Genebank) AK074377(Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) BX640965(Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) NM_018492(PDZ binding kinase), 유전자 등록번호(Genebank) CR600021(High-mobility group box 2), 유전자 등록번호(Genebank) NM_006101(Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003318(TTK protein kinase), 유전자 등록번호(Genebank) U65410[MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_001067(Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) AB091343(Centrosomal protein 55kDa) 및 유전자 등록번호(Genebank) BC022255[Spindle pole body component 25 homolog(S. cerevisiae)] 등이다.
상기 유전자들의 발현변화 정도를 조사 및 정량하기 위해 상기 유전자들의 mRNA를 특이적으로 발현할 수 있는 프라이머를 제작하여(표 4), My IQ 실시간 PCR(My IQ Real-time PCR)(Bio-rad, USA)을 이용하여 정량적인 실시간 RT-PCR을 실시하였다.
구체적으로, 올리고 dT 프라이머와 Superscript kit(Omniscipt™ kit, Qiagen, Co., USA)를 이용하여 역전사반응을 수행하여 cDNA를 합성하였다. PCR 산물을 정량하기 위하여 사이버그린(SYBR Green) I 염색(Bio-rad, USA)으로 염색하였다. 사이버그린 I 염색은 이중나선 DNA에 결합하는 염색법으로서, PCR 과정 동안 이중나선 DNA가 생성될수록 형광강도(fluroscense intensity)가 증가하게 된다. 먼저 PCR에 이용한 표적 유전자와 내재성(endogenous) 대조군(GAPDH)에 대한 프라이머를 사이버그린 마스터 믹스(Master mix)에 첨가하여 PCR을 실시한 후, 적절한 농도를 선택하는 프라이머 적합화(primer optimization) 과정을 수행하였다. 합성된 cDNA 시료와 각각의 프라이머(표 4)를 혼합하고, 사이버그린 마스터 믹스를 첨가한 후 PCR를 수행하였고, 정량 소프트웨어(software)를 사용하여 분석하였다.
등록번호 | 유전자명 | PCR 프라이머 서열 | |
NM_000499 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 센스(서열번호1) | CACCATCCCCCACAGCAC |
안티센스(서열번호2) | ACAAAGACACAACGCCCCTT | ||
BX649164 | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 | 센스(서열번호3) | CAGACCAAGAGCCTCTCCAC |
안티센스(서열번호4) | ATCACTTGGCCCATGAAAAG | ||
NM_004881 | Tumor protein p53 inducible protein 3 | 센스(서열번호5) | AGGGTGAAGTCCTCCTGAAGGT |
안티센스(서열번호6) | GTGGGTCATACTGGCCTTGTCT | ||
BM913048 | TIMPmetallopeptidaseinhibitor1 | 센스(서열번호7) | GATACTTCCACAGGTCCCACAAC |
안티센스(서열번호8) | GCAAGAGTCCATCCTGCAGTT | ||
NM_006426 | Dihydropyrimidinase-like4 | 센스(서열번호9) | TGGGAAGATGGACGAGAATGAGTTCG |
안티센스(서열번호10) | ACTCCACTCCCTCGAAGATGTTGT | ||
NM_133493 | CD109 antigen(Gov platelet alloantigens) | 센스(서열번호11) | GCCAAGATTTACCACGTTTGCCCA |
안티센스(서열번호12) | TGAAGGACCAGAACTGAGCCACAT | ||
AB033073 | Sulfatase 2 | 센스(서열번호13) | TGCGGATATGGACGGGAAATCCAT |
안티센스(서열번호14) | TCTCTTGTGTAGCAGCTTGCCTCT | ||
NM_021603 | FXYD domain containing ion transport regulator 2 | 센스(서열번호15) | GGCAATAAGAAGCGCAGGCAAATC |
안티센스(서열번호16) | AAGGTCTAAAGCCCAGGGAAGAAG | ||
BC035124 | MSFL2541 | 센스(서열번호17) | TTCGCCGTCCTTTACATCTAC |
안티센스(서열번호18) | AGAGCCTGGGGACTCACAT | ||
Y11307 | Cysteine-rich, angiogenic inducer, 61 | 센스(서열번호19) | ATTGTAGAAAGGAAGCCTTGCTCAT |
안티센스(서열번호20) | TCCAATCGTGGCTGCATTAG | ||
AK095363 | Aquaporin 3 | 센스(서열번호21) | TTCACGATCCACCCTTTCAGGCTA |
안티센스(서열번호22) | ACACATACCTGCTGCCCATTCTCT | ||
AK097009 | Phospholipid transfer protein | 센스(서열번호23) | TGCCACAGAGAAGACGGGATTTGA |
안티센스(서열번호24) | AGGTGGTGGACGGACTGTAATTGA | ||
NM_004864 | Growth differentiation factor 15 | 센스(서열번호25) | CCTGAGACACCCGATTCCT |
안티센스(서열번호26) | ACAGTTCCATCAGACCAGCC | ||
BU587578 | Regulator of G-protein signalling 10 | 센스(서열번호27) | CCGTGCCGGGTTTATCATTGCTTT |
안티센스(서열번호28) | TCGACGTGTCCAGTGTTGAAGGAA | ||
BQ683841 | S100 calcium binding protein A11(calgizzarin) | 센스(서열번호29) | AGTCCCTGATTGCTGTCTTCCAGA |
안티센스(서열번호30) | ACCAGGGTCCTTCTGGTTCTTTGT | ||
NM_001013632 | polo-like kinase 3 (Drosophila) | 센스(서열번호31) | GACTACTCCAATAAGTTCGGCTTTG |
안티센스(서열번호32) | CATATGTGTGCCATCGTTGAAGA | ||
NM_032872 | Synaptotagmin-like 1 | 센스(서열번호33) | GGCGGTGAAGAAACGGAATCTGAA |
안티센스(서열번호34) | GAAAGATGTTGCGACCCAGGCTTT | ||
BC042390 | Vesicle transport through interaction with t-SNAREs homolog 1B(yeast) | 센스(서열번호35) | GGGGGACTAACCTATCGAGAA |
안티센스(서열번호36) | GATCCAGTGCTGATAGCAACC | ||
NM_000596 | Insulin-like growth factor binding protein 1 | 센스(서열번호37) | ATCATTCCATCCTTTGGGACGCCA |
안티센스(서열번호38) | TGTCTCCTGTGCCTTGGCTAAACT | ||
NM_005319 | Histone 1, H1c | 센스(서열번호39) | ACCAAACCTAAGAAGCCAGTTG |
안티센스(서열번호40) | TAGCGCTCTTCTTCGGAGTT | ||
AK094474 | Ras homolog gene family, member C | 센스(서열번호41) | ACCTGCCTCCTCATCGTCTTC |
안티센스(서열번호42) | CACCTGCTTGCCGTCCAC | ||
NM_001769 | CD9 antigen(p24) | 센스(서열번호43) | GCACCAAGTGCATCAAATACCTGC |
안티센스(서열번호44) | AGCCATAGTCCAATGGCAAGGACA | ||
NM_001553 | Insulin-like growth factor binding protein 7 | 센스(서열번호45) | ACTTGAGCTGTGAGGTCATCGGAA |
안티센스(서열번호46) | ATACCAGCACCCAGCCAGTTACTT | ||
NM_003897 | Immediate early response 3 | 센스(서열번호47) | AGCCCTTTAATCTGACTTCGGAGC |
안티센스(서열번호48) | CAGGTACGCCTGGTGTTTCTTTGT | ||
NM_003516 | Histone 2, H2aa | 센스(서열번호49) | GAACTGAACAAGCTGCTGGGCAAA |
안티센스(서열번호50) | TCTCCGTCTTCTTAGGGAGCAGTA | ||
AK074377 | Chromosome 19 open reading frame 31 | 센스(서열번호51) | CTGGTACGACGCGGAGAT |
안티센스(서열번호52) | CGACAGTCGTTCAGAGAATCA | ||
BX640965 | Solute carrier family 22(extraneuronal monoamine transporter), member 3 | 센스(서열번호53) | GCCCTGTTCCAGCAATAAGA |
안티센스(서열번호54) | GAGAGCCAAAAATGTCCCAA | ||
NM_018492 | PDZ binding kinase | 센스(서열번호55) | TCTGGACTGAGAGTGGCTTTCACA |
안티센스(서열번호56) | AGCCAAGCTTCTGCATAAACGGAG | ||
CR600021 | High-mobility group box 2 | 센스(서열번호57) | CTTGGCACGATATGCAGCAA |
안티센스(서열번호58) | CAGCCAAAGATAAACAACCATATGA | ||
NM_006101 | Kinetochore associated 2 | 센스(서열번호59) | TGCTACACATGTTGGGTCTGTA |
안티센스(서열번호60) | CCGAGAGATCTTCTGACATGC | ||
NM_003318 | TTK protein kinase | 센스(서열번호61) | TCATGCCCATTTGGAAGAGTCCCA |
안티센스(서열번호62) | AGGCACAACCAAATCTCGGCATTC | ||
U65410 | MAD2 mitotic arrest deficient-like 1(yeast) | 센스(서열번호63) | ACTTAAATATCTCCCTACCTATACTGAGTCAA |
안티센스(서열번호64) | TAGTAACTGTAGATGGAAAAACTTGTGCTA | ||
NM_001067 | Topoisomerase(DNA) II alpha 170kDa | 센스(서열번호65) | CTAGTTAATGCTGCGGACAACA |
안티센스(서열번호66) | CATTTCGACCACCTGTCACTT | ||
AB091343 | Centrosomal protein 55kDa | 센스(서열번호67) | GCTGTGCATTTCTCTTGGCAGTGA |
안티센스(서열번호68) | TAGACGCTGCTCACCACATTCTGT | ||
BC022255 | Spindle pole body component 25 homolog(S. cerevisiae) | 센스(서열번호69) | GAATGGTTGAGATGTTTCTGGA |
안티센스(서열번호70) | GCAATCAATTTTAACAAGTTATCCTTT |
등록번호 | 유전자명 | 약어 | 마이크로어레이 (Cy3/Cy5 비율) | 실시간 PCR(상대적 배율) |
과발현 유전자 | ||||
NM_000499 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | CYP1A1 | 88.34 | 863.07 |
BX649164 | serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 | 29.05 | 38.54 |
NM_004881 | Tumor protein p53 inducible protein 3 | TP53I3 | 16.67 | 26.57 |
BM913048 | TIMP metallopeptidase inhibitor 1 | TIMP1 | 14.52 | 26.48 |
NM_006426 | Dihydropyrimidinase-like 4 | DPYSL4 | 13.51 | 101.13 |
NM_133493 | CD109 antigen(Gov platelet alloantigens) | CD109 | 12.97 | 45.46 |
AB033073 | Sulfatase 2 | SULF2 | 12.78 | 13.78 |
NM_021603 | FXYD domain containing ion transport regulator 2 | FXYD2 | 12.63 | 29.86 |
BC035124 | MSFL2541 | UNQ2541 | 11.28 | 13.61 |
Y11307 | Cysteine-rich, angiogenic inducer, 61 | CYR61 | 8.79 | 12.85 |
AK095363 | Aquaporin 3 | AQP3 | 8.26 | 46.53 |
AK097009 | phospholipid transfer protein | PLTP | 6.84 | 46.74 |
NM_004864 | Growth differentiation factor 15 | GDF15 | 6.65 | 38.76 |
BU587578 | Regulator of G-protein signalling 10 | RGS10 | 6.15 | 13.03 |
BQ683841 | S100 calcium binding protein A11(calgizzarin) | S100A11 | 6.06 | 8.38 |
NM_001013632 | polo-like kinase 3 (Drosophila) | PLK3 | 5.34 | 9.23 |
NM_032872 | Synaptotagmin-like 1 | SYTL1 | 4.93 | 10.43 |
BC042390 | Vesicle transport through interaction with t-SNAREs homolog 1B(yeast) | VTI1B | 4.49 | 8.21 |
NM_000596 | Insulin-like growth factor binding protein 1 | IGFBP1 | 4.43 | 5.07 |
NM_005319 | Histone 1, H1c | HIST1H1C | 4.26 | 3.38 |
AK094474 | Ras homolog gene family, member C | RHOC | 4.23 | 3.41 |
NM_001769 | CD9 antigen(p24) | CD9 | 4.15 | 1.71 |
NM_001553 | Insulin-like growth factor binding protein 7 | IGFBP7 | 3.47 | 11.02 |
NM_003897 | Immediate early response 3 | IER3 | 3.32 | 6.84 |
NM_003516 | Histone 2, H2aa | HIST2H2AA | 3.05 | 3.47 |
저발현 유전자 | ||||
AK074377 | Chromosome 19 open reading frame 31 | UHRF1 | 0.16 | 0.19 |
BX640965 | Solute carrier family 22(extraneuronal monoamine transporter), member 3 | SLC22A3 | 0.26 | 0.23 |
NM_018492 | PDZ binding kinase | PBK | 0.28 | 0.21 |
CR600021 | High-mobility group box 2 | HMGB2 | 0.29 | 0.23 |
NM_006101 | Kinetochore associated 2 | KNTC2 | 0.30 | 0.26 |
NM_003318 | TTK protein kinase | TTK | 0.30 | 0.47 |
U65410 | MAD2 mitotic arrest deficient-like 1(yeast) | MAD2L1 | 0.34 | 0.34 |
NM_001067 | Topoisomerase(DNA) II alpha 170kDa | TOP2A | 0.45 | 0.14 |
AB091343 | Centrosomal protein 55kDa | C10orf3 | 0.45 | 0.63 |
BC022255 | Spindle pole body component 25 homolog(S. cerevisiae) | Spc25 | 0.54 | 0.25 |
그 결과, 표 5에서 나타난 바와 같이 25종의 과발현 유전자들 및 10종의 저발현 유전자의 유전자 발현 양상은 크라이센에 의한 유전자 발현을 조사한 올리고 마이크로어레이 결과와 매우 유사하게 나타남을 확인하였다.
도 1은 크라이센(chrysene)의 인간 간암 세포주에서의 세포 독성을 조사한 그래프이다.
도 2는 마이크로어레이 칩을 이용한 크라이센을 처리한 인간 간암 세포주의 유전자 발현 양상을 분석한 결과를 나타내는 그림이다.
<110> Korea Institute of Science and Technology
<120> Biomarker for identification of exoposure to chrysene and the
method of identification using thereof
<130> 8P-05-09
<160> 70
<170> KopatentIn 1.71
<210> 1
<211> 18
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_000499 sense primer
<400> 1
caccatcccc cacagcac 18
<210> 2
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_000499 antisense primer
<400> 2
acaaagacac aacgcccctt 20
<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> BX649164 sense primer
<400> 3
cagaccaaga gcctctccac 20
<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> BX649164 antisense primer
<400> 4
atcacttggc ccatgaaaag 20
<210> 5
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_004881 sense primer
<400> 5
agggtgaagt cctcctgaag gt 22
<210> 6
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_004881 antisense primer
<400> 6
gtgggtcata ctggccttgt ct 22
<210> 7
<211> 23
<212> DNA
<213> Artificial Sequence
<220>
<223> BM913048 sense primer
<400> 7
gatacttcca caggtcccac aac 23
<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> BM913048 antisense primer
<400> 8
gcaagagtcc atcctgcagt t 21
<210> 9
<211> 26
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_006426 sense primer
<400> 9
tgggaagatg gacgagaatg agttcg 26
<210> 10
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_006426 antisense primer
<400> 10
actccactcc ctcgaagatg ttgt 24
<210> 11
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_133493 sense primer
<400> 11
gccaagattt accacgtttg ccca 24
<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_133493 antisense primer
<400> 12
tgaaggacca gaactgagcc acat 24
<210> 13
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AB03307 sense primer
<400> 13
tgcggatatg gacgggaaat ccat 24
<210> 14
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AB03307 antisense primer
<400> 14
tctcttgtgt agcagcttgc ctct 24
<210> 15
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_021603 sense primer
<400> 15
ggcaataaga agcgcaggca aatc 24
<210> 16
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_021603 antisense primer
<400> 16
aaggtctaaa gcccagggaa gaag 24
<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> BC035124 sense primer
<400> 17
ttcgccgtcc tttacatcta c 21
<210> 18
<211> 19
<212> DNA
<213> Artificial Sequence
<220>
<223> BC035124 antisense primer
<400> 18
agagcctggg gactcacat 19
<210> 19
<211> 25
<212> DNA
<213> Artificial Sequence
<220>
<223> Y11307 sense primer
<400> 19
attgtagaaa ggaagccttg ctcat 25
<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> Y11307 antisense primer
<400> 20
tccaatcgtg gctgcattag 20
<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AK095363 sense primer
<400> 21
ttcacgatcc accctttcag gcta 24
<210> 22
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AK095363 antisense primer
<400> 22
acacatacct gctgcccatt ctct 24
<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AK097009 sense primer
<400> 23
tgccacagag aagacgggat ttga 24
<210> 24
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AK097009 antisense primer
<400> 24
aggtggtgga cggactgtaa ttga 24
<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_004864 sense primer
<400> 25
cctgagacac ccgattcct 19
<210> 26
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_004864 antisense primer
<400> 26
acagttccat cagaccagcc 20
<210> 27
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> BU587578 sense primer
<400> 27
ccgtgccggg tttatcattg cttt 24
<210> 28
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> BU587578 antisense primer
<400> 28
tcgacgtgtc cagtgttgaa ggaa 24
<210> 29
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> BQ683841 sense primer
<400> 29
agtccctgat tgctgtcttc caga 24
<210> 30
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> BQ683841 antisense primer
<400> 30
accagggtcc ttctggttct ttgt 24
<210> 31
<211> 25
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001013632 sense primer
<400> 31
gactactcca ataagttcgg ctttg 25
<210> 32
<211> 23
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001013632 antisense primer
<400> 32
catatgtgtg ccatcgttga aga 23
<210> 33
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_032872 sense primer
<400> 33
ggcggtgaag aaacggaatc tgaa 24
<210> 34
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_032872 antisense primer
<400> 34
gaaagatgtt gcgacccagg cttt 24
<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> BC042390 sense primer
<400> 35
gggggactaa cctatcgaga a 21
<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> BC042390 antisense primer
<400> 36
gatccagtgc tgatagcaac c 21
<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_000596 sense primer
<400> 37
atcattccat cctttgggac gcca 24
<210> 38
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_000596 antisense primer
<400> 38
tgtctcctgt gccttggcta aact 24
<210> 39
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_005319 sense primer
<400> 39
accaaaccta agaagccagt tg 22
<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_005319 antisense primer
<400> 40
tagcgctctt cttcggagtt 20
<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> AK094474 sense primer
<400> 41
acctgcctcc tcatcgtctt c 21
<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence
<220>
<223> AK094474 antisense primer
<400> 42
cacctgcttg ccgtccac 18
<210> 43
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001769 sense primer
<400> 43
gcaccaagtg catcaaatac ctgc 24
<210> 44
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001769 antisense primer
<400> 44
agccatagtc caatggcaag gaca 24
<210> 45
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001553 sense primer
<400> 45
acttgagctg tgaggtcatc ggaa 24
<210> 46
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001553 antisense primer
<400> 46
ataccagcac ccagccagtt actt 24
<210> 47
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003897 sense primer
<400> 47
agccctttaa tctgacttcg gagc 24
<210> 48
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003897 antisense primer
<400> 48
caggtacgcc tggtgtttct ttgt 24
<210> 49
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003516 sense primer
<400> 49
gaactgaaca agctgctggg caaa 24
<210> 50
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003516 antisense primer
<400> 50
tctccgtctt cttagggagc agta 24
<210> 51
<211> 18
<212> DNA
<213> Artificial Sequence
<220>
<223> AK074377 sense primer
<400> 51
ctggtacgac gcggagat 18
<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> AK074377 antisense primer
<400> 52
cgacagtcgt tcagagaatc a 21
<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> BX640965 sense primer
<400> 53
gccctgttcc agcaataaga 20
<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> BX640965 antisense primer
<400> 54
gagagccaaa aatgtcccaa 20
<210> 55
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_018492 sense primer
<400> 55
tctggactga gagtggcttt caca 24
<210> 56
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_018492 antisense primer
<400> 56
agccaagctt ctgcataaac ggag 24
<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence
<220>
<223> CR600021 sense primer
<400> 57
cttggcacga tatgcagcaa 20
<210> 58
<211> 25
<212> DNA
<213> Artificial Sequence
<220>
<223> CR600021 antisense primer
<400> 58
cagccaaaga taaacaacca tatga 25
<210> 59
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_006101 sense primer
<400> 59
tgctacacat gttgggtctg ta 22
<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_006101 antisense primer
<400> 60
ccgagagatc ttctgacatg c 21
<210> 61
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003318 sense primer
<400> 61
tcatgcccat ttggaagagt ccca 24
<210> 62
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_003318 antisense primer
<400> 62
aggcacaacc aaatctcggc attc 24
<210> 63
<211> 32
<212> DNA
<213> Artificial Sequence
<220>
<223> U65410 sense primer
<400> 63
acttaaatat ctccctacct atactgagtc aa 32
<210> 64
<211> 30
<212> DNA
<213> Artificial Sequence
<220>
<223> U65410 antisense primer
<400> 64
tagtaactgt agatggaaaa acttgtgcta 30
<210> 65
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001067 sense primer
<400> 65
ctagttaatg ctgcggacaa ca 22
<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> NM_001067 antisense primer
<400> 66
catttcgacc acctgtcact t 21
<210> 67
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AB091343 sense primer
<400> 67
gctgtgcatt tctcttggca gtga 24
<210> 68
<211> 24
<212> DNA
<213> Artificial Sequence
<220>
<223> AB091343 antisense primer
<400> 68
tagacgctgc tcaccacatt ctgt 24
<210> 69
<211> 22
<212> DNA
<213> Artificial Sequence
<220>
<223> BC022255 sense primer
<400> 69
gaatggttga gatgtttctg ga 22
<210> 70
<211> 27
<212> DNA
<213> Artificial Sequence
<220>
<223> BC022255 antisense primer
<400> 70
gcaatcaatt ttaacaagtt atccttt 27
Claims (15)
- 하기의 군으로부터 선택되는 유전자를 포함하는 크라이센에 대한 노출 여부 확인용 바이오마커:유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807[APLP1, Amyloid beta(A4) precursor-like protein 1], 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen, (lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble (opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전 자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번 호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5), 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo), 유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번 호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유 전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983[SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide-specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번 호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번 호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT-binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번 호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid-5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번 호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135[DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
- 제 1항에 있어서, 하기 유전자가 크라이센의 노출에 의해 발현이 증가하는 것을 특징으로 하는 바이오마커:유전자 등록번호(Genebank) NM_003954(MAP3K14, Mitogen-activated protein kinase kinase kinase 14), 유전자 등록번호(Genebank) AB209586(MAPK13, Mitogen-activated protein kinase 13), 유전자 등록번호(Genebank) NM_005343(HRAS, V-Ha-ras Harvey rat sarcoma viral oncogene homolog), 유전자 등록번호(Genebank) BX647104(FOS, V-fos FBJ murine osteosarcoma viral oncogene homolog), 유전자 등록번호(Genebank) NM_007315(STAT1, Signal transducer and activator of transcription 1, 91kDa), 유전자 등록번호(Genebank) BC027933(MAPK11, Mitogen-activated protein kinase 11), 유전자 등록번호(Genebank) NM_020529(NFKBIA, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), 유전자 등록번호(Genebank) BC014966(RPS6KA1, Ribosomal protein S6 kinase, 90kDa, polypeptide 1), 유전자 등록번호(Genebank) NM_181861(APAF1, Apoptotic peptidase activating factor), 유전자 등록번호(Genebank) L41870[RB1, Retinoblastoma 1(including osteosarcoma)], 유전자 등록번호(Genebank) CR612719(GADD45A, Growth arrest and DNA-damage-inducible, alpha), 유전자 등록번호(Genebank) BM462208(PCNA, Proliferating cell nuclear antigen), 유전자 등록번호(Genebank) M92424[MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein(mouse)], 유전자 등록번호(Genebank) NM_078467[CDKN1A, Cyclin-dependent kinase inhibitor 1A(p21, Cip1)], 유전자 등록번호(Genebank) BC089389(IHPK3, Inositol hexaphosphate kinase 3), 유전자 등록번호(Genebank) NM_001024807(APLP1, Amyloid beta(A4) precursor-like protein 1), 유전자 등록번호(Genebank) NM_001013398(IGFBP3, Insulin-like growth factor binding protein 3), 유전자 등록번호(Genebank) AB209361[FAS, Fas(TNF receptor superfamily, member 6)], 유전자 등록번호(Genebank) NM_147780(CTSB, Cathepsin B), 유전자 등록번호(Genebank) NM_001165(BIRC3, Baculoviral IAP repeat-containing 3), 유전자 등록번호(Genebank) BM557864(HSPB1, Heat shock 27kDa protein 1), 유전자 등록번호(Genebank) AB033060(PDCD6, Aryl-hydrocarbon receptor repressor), 유전자 등록번호(Genebank) AK125880(TP53INP1, Tumor protein p53 inducible nuclear protein 1), 유전자 등록번호(Genebank) NM_004574(SEP4, Septin 4), 유전자 등록번호(Genebank) NM_003820[TNFRSF14, Tumor necrosis factor receptor superfamily, member 14(herpesvirus entry mediator)], 유전자 등록번호(Genebank) CN478604[LGALS7, Lectin, galactoside-binding, soluble, 7(galectin 7)], 유전자 등록번호(Genebank) NM_004879(EI24, Etoposide induced 2.4 mRNA), 유전자 등록번호(Genebank) NM_003311(PHLDA2, Pleckstrin homology-like domain, family A, member 2), 유전자 등록번호(Genebank) NM_003897(IER3, Immediate early response 3), 유전자 등록번호(Genebank) AK097284(TNFAIP8, Tumor necrosis factor, alpha-induced protein 8), 유전자 등록번호(Genebank) NM_000582[SPP1, Secreted phosphoprotein 1(osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)], 유전자 등록번호(Genebank) NM_013258(PYCARD, PYD and CARD domain containing), 유전자 등록번호(Genebank) NM_002305[LGALS1, Lectin, galactoside-binding, soluble, 1(galectin 1)], 유전자 등록번호(Genebank) AF055634[UNC5C, Unc-5 homolog C(C. elegans)], 유전자 등록번호(Genebank) CR614015(CD14, CD14 antigen), 유전자 등록번호(Genebank) AK129595(GADD45B, Growth arrest and DNA-damage-inducible, beta), 유전자 등록번호(Genebank) AF356193(CARD6, Caspase recruitment domain family, member 6), 유전자 등록번호(Genebank) BC063043[PRF1, Perforin 1(pore forming protein)], 유전자 등록번호(Genebank) BX537586[STK17A, Serine/threonine kinase 17a(apoptosis-inducing)], 유전자 등록번호(Genebank) NM_003842(TNFRSF10B, Tumor necrosis factor receptor superfamily, member 10b), 유전자 등록번호(Genebank) AF208043(IFI16, Interferon, gamma-inducible protein 16), 유전자 등록번호(Genebank) BX641114(ANXA4, Annexin A4), 유전자 등록번호(Genebank) NM_001009552(PPP2CB, Protein phosphatase 2(formerly 2A), catalytic subunit, beta isoform), 유전자 등록번호(Genebank) BX386171(CGB5, Chorionic gonadotropin, beta polypeptide 8), 유전자 등록번호(Genebank) AY358103(HIP1, Huntingtin interacting protein 1), 유전자 등록번호(Genebank) BC027949(P2RX1, Purinergic receptor P2X, ligand-gated ion channel, 1), 유전자 등록번호(Genebank) BC042844(CASP10, Caspase 10, apoptosis-related cysteine peptidase), 유전자 등록번호(Genebank) NM_000733[CD3E, CD3E antigen, epsilon polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) NM_033245(PML, Promyelocytic leukemia), 유전자 등록번호(Genebank) BC047362(PHLDA1, Pleckstrin homology-like domain, family A, member 1), 유전자 등록번호(Genebank) NM_006763(BTG2, BTG family, member 2), 유전자 등록번호(Genebank) BC050455(DDB2, LIM homeobox 3), 유전자 등록번호(Genebank) BC068535(TP53AP1, TP53 activated protein 1), 유전자 등록번호(Genebank) AF033122(SESN1, Sestrin 1), 유전자 등록번호(Genebank) AB024313(POLH, Polymerase(DNA directed), eta), 유전자 등록번호(Genebank) NM_001012716(TYMS, Thymidylate synthetase), 유전자 등록번호(Genebank) BC095402(ATXN3, Ataxin 3), 유전자 등록번호(Genebank) BU675073(PTTG1, Pituitary tumor-transforming 1), 유전자 등록번호(Genebank) BC073161(RAD51C, RAD51 homolog C(S. cerevisiae), 유전자 등록번호(Genebank) NM_001983[ERCC1, Excision repair cross-complementing rodent repair deficiency, complementation group 1(includes overlapping antisense sequence)], 유전자 등록번호(Genebank) NM_018965(TREM2, Triggering receptor expressed on myeloid cells 2), 유전자 등록번호(Genebank) BX649164(PAI, serpin peptidase inhibitor, clade E(nexin, plasminogen activator inhibitor type 1), member 1), 유전자 등록번호(Genebank) NM_006404[PROCR, Protein C receptor, endothelial(EPCR)], 유전자 등록번호(Genebank) C035582(TRIM22, Tripartite motif-containing 22), 유전자 등록번호(Genebank) NM_006691(XLKD1, Extracellular link domain containing 1), 유전자 등록번호(Genebank) NM_015831[ACHE, Acetylcholinesterase(YT blood group)], 유전자 등록번호(Genebank) BC045666(TP53I11, Tumor protein p53 inducible protein 11), 유전자 등록번호(Genebank) NM_005438(FOSL1, FOS-like antigen 1), 유전자 등록번호(Genebank) NM_005755(EBI3, Epstein-Barr virus induced gene 3), 유전자 등록번호(Genebank) BM918324(LY96, Lymphocyte antigen 96), 유전자 등록번호(Genebank) NM_000022(ADA, Adenosine deaminase), 유전자 등록번호(Genebank) NM_004167(CCL14, Chemokine(C-C motif) ligand 15), 유전자 등록번호(Genebank) NM_014278(HSPA4L, Heat shock 70kDa protein 4-like), 유전자 등록번호(Genebank) BC006523(SGK2, Serum/glucocorticoid regulated kinase 2), 유전자 등록번호(Genebank) NM_000641(IL11, Interleukin 11), 유전자 등록번호(Genebank) H18681[C20orf139, Sulfiredoxin 1 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_001769[CD9, CD9 antigen(p24)], 유전자 등록번호(Genebank) BG564326(SAA4, Serum amyloid A4, constitutive), 유전자 등록번호(Genebank) NM_016816(OAS1, 2',5'-oligoadenylate synthetase 1, 40/46kDa), 유전자 등록번호(Genebank) CB055213(ICOSLG, Inducible T-cell co-stimulator ligand), 유전자 등록번호(Genebank) CR591007(CCL3, Chemokine(C-C motif) ligand 3), 유전자 등록번호(Genebank) NM_145641(APOL3, Apolipoprotein L, 3), 유전자 등록번호(Genebank) AK127663(PTGES, Prostaglandin E synthase), 유전자 등록번호(Genebank) NM_001734(C1S, Complement component 1, s subcomponent), 유전자 등록번호(Genebank) NM_002260(KLRC3, Killer cell lectin-like receptor subfamily C, member 2), 유전자 등록번호(Genebank) NM_001733(C1R, Complement component 1, r subcomponent), 유전자 등록번호(Genebank) AB209922(DNAJB4, DnaJ(Hsp40) homolog, subfamily B, member 4), 유전자 등록번호(Genebank) NM_201397(GPX1, Glutathione peroxidase 1), 유전자 등록번호(Genebank) AK090482[CXCL12, Chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)], 유전자 등록번호(Genebank) BF662985(CCL3L1, Chemokine(C-C motif) ligand 3-like 1), 유전자 등록번호(Genebank) NM_001779[CD58, CD58 antigen,(lymphocyte function-associated antigen 3)], 유전자 등록번호(Genebank) NM_005064(CCL23, Chemokine(C-C motif) ligand 23), 유전자 등록번호(Genebank) NM_000242[MBL2, Mannose-binding lectin(protein C) 2, soluble(opsonic defect)], 유전자 등록번호(Genebank) NM_032036(FAM14A, Family with sequence similarity 14, member A), 유전자 등록번호(Genebank) AJ890082(HSPCA, Heat shock 90kDa protein 1, alpha), 유전자 등록번호(Genebank) BC068487(TLR3, Toll-like receptor 3), 유전자 등록번호(Genebank) NM_000552(VWF, Von Willebrand factor), 유전자 등록번호(Genebank) NM_000132[F8, Coagulation factor VIII, procoagulant component(hemophilia A)], 유전자 등록번호(Genebank) AY154461(NALP6, NACHT, leucine rich repeat and PYD containing 6), 유전자 등록번호(Genebank) AK127679(DUSP1, Dual specificity phosphatase 1), 유전자 등록번호(Genebank) NM_014314(DDX58, DEAD(Asp-Glu-Ala-Asp) box polypeptide 58), 유전자 등록번호(Genebank) NM_000311[PRNP, Prion protein(p27-30)(Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)], 유전자 등록번호(Genebank) NM_006597(HSPA8, Heat shock 70kDa protein 8), 유전자 등록번호(Genebank) AK092040(ZCSL2, Zinc finger, CSL-type containing 2), 유전자 등록번호(Genebank) NM_031483[ITCH, Itchy homolog E3 ubiquitin protein ligase(mouse)], 유전자 등록번호(Genebank) U25029[NR3C1, Nuclear receptor subfamily 3, group C, member 1(glucocorticoid receptor)], 유전자 등록번호(Genebank) NM_005242(F2RL1, Coagulation factor II(thrombin) receptor-like 1), 유전자 등록번호(Genebank) AK172851(ADORA2B, Adenosine A2b receptor), 유전자 등록번호(Genebank) BQ053419(BATF, Basic leucine zipper transcription factor, ATF-like), 유전자 등록번호(Genebank) BC020698(CCL20, Chemokine(C-C motif) ligand 20), 유전자 등록번호(Genebank) NM_001124(ADM, Adrenomedullin), 유전자 등록번호(Genebank) NM_153609(TMPRSS6, Transmembrane protease, serine 6), 유전자 등록번호(Genebank) NM_004148(NINJ1, Ninjurin 1), 유전자 등록번호(Genebank) AF324224(APOL2, Apolipoprotein L, 2), 유전자 등록번호(Genebank) BC040494(DNAJB2, DnaJ(Hsp40) homolog, subfamily B, member 2), 유전자 등록번호(Genebank) BE512691[GPX2, Glutathione peroxidase 2(gastrointestinal)], 유전자 등록번호(Genebank) NM_001002029(C4A, Complement component 4B, telomeric), 유전자 등록번호(Genebank) NM_000732[CD3D, CD3D antigen, delta polypeptide(TiT3 complex)], 유전자 등록번호(Genebank) AK223210[CD79B, CD79B antigen(immunoglobulin-associated beta)], 유전자 등록번호(Genebank) NM_002309(LIF, Hypothetical protein MGC20647), 유전자 등록번호(Genebank) AF031469(MR1, Major histocompatibility complex, class I-related), 유전자 등록번호(Genebank) NM_172208[TAPBP, TAP binding protein(tapasin)], 유전자 등록번호(Genebank) BC021117[CSF1, Colony stimulating factor 1(macrophage)], 유전자 등록번호(Genebank) NM_001421[ELF4, E74-like factor 4(ets domain transcription factor)], 유전자 등록번호(Genebank) NM_002119(HLA-DOA, Major histocompatibility complex, class II, DO alpha), 유전자 등록번호(Genebank) BX648013[TAP1, Transporter 1, ATP-binding cassette, sub-family B(MDR/TAP)], 유전자 등록번호(Genebank) AL832287(ZAP70, Zeta-chain(TCR) associated protein kinase 70kDa), 유전자 등록번호(Genebank) BF569086(NK4, Interleukin 32), 유전자 등록번호(Genebank) AL832451(DKFZp451C2311, guanylate binding protein 2, interferon-inducible), 유전자 등록번호(Genebank) AF069493(SEMA7A, Sema domain, immunoglobulin domain(Ig), and GPI membrane anchor,(semaphorin) 7A), 유전자 등록번호(Genebank) NM_001008490(KLF6, Kruppel-like factor 6), 유전자 등록번호(Genebank) NM_000418(IL4R, Interleukin 4 receptor), 유전자 등록번호(Genebank) NM_004048(B2M, Beta-2-microglobulin), 유전자 등록번호(Genebank) AF116720(DNAJA2, DnaJ(Hsp40) homolog, subfamily A, member 2), 유전자 등록번호(Genebank) NM_001007271(DUSP13, Dual specificity phosphatase 13), 유전자 등록번호(Genebank) BM904612[S100A6, S100 calcium binding protein A6(calcyclin)], 유전자 등록번호(Genebank) AK074652(SERTAD1, SERTA domain containing 1), 유전자 등록번호(Genebank) NM_203394(E2F7, E2F transcription factor 7), 유전자 등록번호(Genebank) NM_003620(PPM1D, Protein phosphatase 1D magnesium-dependent, delta isoform), 유전자 등록번호(Genebank) BC060797[PARD6G, Par-6 partitioning defective 6 homolog gamma(C. elegans)], 유전자 등록번호(Genebank) NM_021913(AXL, AXL receptor tyrosine kinase), 유전자 등록번호(Genebank) BC040303(PTP4A1, Protein tyrosine phosphatase type IVA, member 1), 유전자 등록번호(Genebank) BC008564(PPP1R9B, Protein phosphatase 1, regulatory subunit 9B, spinophilin), 유전자 등록번호(Genebank) AK097024[RAE1, RAE1 RNA export 1 homolog(S. pombe)], 유전자 등록번호(Genebank) BC011957(BTG3, BTG family, member 3), 유전자 등록번호(Genebank) NM_078487[CDKN2B, Cyclin-dependent kinase inhibitor 2B(p15, inhibits CDK4)], 유전자 등록번호(Genebank) BC023552(SFN, Stratifin), 유전자 등록번호(Genebank) BC060847[PARD6B, Par-6 partitioning defective 6 homolog beta(C. elegans)], 유전자 등록번호(Genebank) NM_003236(TGFA, Transforming growth factor, alpha), 유전자 등록번호(Genebank) NM_002632(PGF, Placental growth factor, vascular endothelial growth factor-related protein), 유전자 등록번호(Genebank) NM_015278(SASH1, SAM and SH3 domain containing 1), 유전자 등록번호(Genebank) AL834276(MGC3207, Hypothetical protein MGC3207), 유전자 등록번호(Genebank) AK096276(CCND3, Cyclin D3), 유전자 등록번호(Genebank) AB209373(CCNK, Chromosome 14 open reading frame 65), 유전자 등록번호(Genebank) NM_021132[PPP3CB, Protein phosphatase 3(formerly 2B), catalytic subunit, beta isoform(calcineurin A beta)], 유전자 등록번호(Genebank) NM_005072(SLC12A4, Solute carrier family 12(potassium/chloride transporters), member 4), 유전자 등록번호(Genebank) BX647886[PCNP, SPT2, Suppressor of Ty, domain containing 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_044472[CDC42, Cell division cycle 42(GTP binding protein, 25kDa)], 유전자 등록번호(Genebank) AL832973[REC8L1, REC8-like 1(yeast)], 유전자 등록번호(Genebank) NM_002031(FRK, Fyn-related kinase), 유전자 등록번호(Genebank) BM913048(TIMP1, TIMP metallopeptidase inhibitor 1), 유전자 등록번호(Genebank) NM_003975(SH2D2A, SH2 domain protein 2A), 유전자 등록번호(Genebank) NM_198129(LAMA3, Laminin, alpha 3), 유전자 등록번호(Genebank) NM_006152(LRMP, Lymphoid-restricted membrane protein), 유전자 등록번호(Genebank) X96753[CSPG4, Chondroitin sulfate proteoglycan 4(melanoma-associated)], 유전자 등록번호(Genebank) NM_000474[TWIST1, Twist homolog 1(acrocephalosyndactyly 3; Saethre-Chotzen syndrome)(Drosophila)], 유전자 등록번호(Genebank) AF052152(DCAMKL1, Doublecortin and CaM kinase-like 1), 유전자 등록번호(Genebank) AF333334(CCIN, Calicin), 유전자 등록번호(Genebank) NM_005979(S100A13, S100 calcium binding protein A13), 유전자 등록번호(Genebank) NM_004429(EFNB1, Ephrin-B1), 유전자 등록번호(Genebank) NM_003873(NRP1, Neuropilin 1), 유전자 등록번호(Genebank) AF026692(SFRP4, Secreted frizzled-related protein 4), 유전자 등록번호(Genebank) AK124583(DAZAP1, DAZ associated protein 1), 유전자 등록번호(Genebank) AF003837[JAG1, Jagged 1(Alagille syndrome)], 유전자 등록번호(Genebank) AB209590(BMP1, Bone morphogenetic protein 1), 유전자 등록번호(Genebank) X54457[CEL, Carboxyl ester lipase(bile salt-stimulated lipase)], 유전자 등록번호(Genebank) Y11307(CYR61, Cysteine-rich, angiogenic inducer, 61), 유전자 등록번호(Genebank) NM_000596(IGFBP1, Insulin-like growth factor binding protein 1), 유전자 등록번호(Genebank) NM_020997(LEFTY1, Left-right determination factor 1), 유전자 등록번호(Genebank) NM_001553(IGFBP7, Insulin-like growth factor binding protein 7), 유전자 등록번호(Genebank) AB209509(IGFBP2, Insulin-like growth factor binding protein 2, 36kDa), 유전자 등록번호(Genebank) NM_001552(IGFBP4, Insulin-like growth factor binding protein 4), 유전자 등록번호(Genebank) AB209321(CSRP2, Cysteine and glycine-rich protein 2), 유전자 등록번호(Genebank) BM556279(EMP3, Epithelial membrane protein 3), 유전자 등록번호(Genebank) NM_005727(TSPAN1, Tetraspanin 1), 유전자 등록번호(Genebank) BQ683841[S100A11, S100 calcium binding protein A11(calgizzarin)], 유전자 등록번호(Genebank) BC042390[VTI1B, Vesicle transport through interaction with t-SNAREs homolog 1B(yeast)], 유전자 등록번호(Genebank) NM_000899(KITLG, KIT ligand), 유전자 등록번호(Genebank) BC032940(LAMP3, Lysosomal-associated membrane protein 3), 유전자 등록번호(Genebank) BQ939577[AKR1C3, Aldo-keto reductase family 1, member C3(3-alpha hydroxysteroid dehydrogenase, type II)], 유전자 등록번호(Genebank) BC063468(OSMR, Oncostatin M receptor), 유전자 등록번호(Genebank) CR936719[SSR1, Signal sequence receptor, alpha(translocon-associated protein alpha)], 유전자 등록번호(Genebank) AB024057[TBC1D8, TBC1 domain family, member 8(with GRAM domain)], 유전자 등록번호(Genebank) NM_003329(TXN, Thioredoxin), 유전자 등록번호(Genebank) NM_012125(CHRM5, Cholinergic receptor, muscarinic 5), 유전자 등록번호(Genebank) NM_007045(FGFR1OP, FGFR1 oncogene partner), 유전자 등록번호(Genebank) AK094474(RHOC, Ras homolog gene family, member C), 유전자 등록번호(Genebank) BC017706(6PGL, 6-phosphogluconolactonase), 유전자 등록번호(Genebank) AF153821(ADH1B, Alcohol dehydrogenase IB(class I), beta polypeptide), 유전자 등록번호(Genebank) AK124656[ENO2, Enolase 2(gamma, neuronal)], 유전자 등록번호(Genebank) D42047(GPD1L, Glycerol-3-phosphate dehydrogenase 1-like), 유전자 등록번호(Genebank) AK130060(TALDO1, Transaldolase 1), 유전자 등록번호(Genebank) AL833069(KIAA1434, Hypothetical protein KIAA1434), 유전자 등록번호(Genebank) XM_496436(UNQ6077, C219-reactive peptide), 유전자 등록번호(Genebank) NM_199186(BPGM, 2,3-bisphosphoglycerate mutase), 유전자 등록번호(Genebank) U86136(TEP1, Telomerase-associated protein 1), 유전자 등록번호(Genebank) BU603483(HIST1H1E, Histone 1, H1e), 유전자 등록번호(Genebank) NM_005319(HIST1H1C, Histone 1, H1c), 유전자 등록번호(Genebank) NM_005320(HIST1H1D, Histone 1, H1d), 유전자 등록번호(Genebank) NM_003516(HIST2H2AA, Histone 2, H2aa), 유전자 등록번호(Genebank) F02250(HDAC2, Histone deacetylase 2), 유전자 등록번호(Genebank) NM_004739(MTA2, Metastasis associated 1 family, member 2), 유전자 등록번호(Genebank) BC042589(HIST1H2BD, Histone 1, H2bd), 유전자 등록번호(Genebank) CB529694(HIST2H2BE, Histone 2, H2be), 유전자 등록번호(Genebank) AK126154(NP, Nucleoside phosphorylase), 유전자 등록번호(Genebank) AB040899(KIAA1466, KIAA1466 gene), 유전자 등록번호(Genebank) CR608156(HIST1H2AC, Histone 1, H2ac), 유전자 등록번호(Genebank) BX436525(HIST1H2BH, Histone 1, H2bh), 유전자 등록번호(Genebank) AK057762(TDH, L-threonine dehydrogenase), 유전자 등록번호(Genebank) BC035124(UNQ2541, MSFL2541), 유전자 등록번호(Genebank) BC034763(FDXR, Ferredoxin reductase), 유전자 등록번호(Genebank) AK093461(ISYNA1, Myo-inositol 1-phosphate synthase A1), 유전자 등록번호(Genebank) AK097009(PLTP, phospholipid transfer protein), 유전자 등록번호(Genebank) AF524864[AKR1B10, Aldo-keto reductase family 1, member B10(aldose reductase)], 유전자 등록번호(Genebank) NM_021727(FADS3, Fatty acid desaturase 3), 유전자 등록번호(Genebank) CR627415(HSD3B2, Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2), 유전자 등록번 호(Genebank) CD013987(CYP21A2, Cytochrome P450, family 21, subfamily A, polypeptide 2), 유전자 등록번호(Genebank) BC020744(AKR1C4, Aldo-keto reductase family 1, member C4(chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol),dehydrogenase 4), 유전자 등록번호(Genebank) NM_004753(DHRS3, Dehydrogenase/reductase(SDR family) member 3), 유전자 등록번호(Genebank) BC030207(NR0B2, Nuclear receptor subfamily 0, group B, member 2), 유전자 등록번호(Genebank) AK091948(LTB4DH, Leukotriene B4 12-hydroxydehydrogenase), 유전자 등록번호(Genebank) NM_002900(RBP3, Retinol binding protein 3, interstitial), 유전자 등록번호(Genebank) BX647927(PLCD1, Phospholipase C, delta 1), 유전자 등록번호(Genebank) NM_145323(OSBPL3, Oxysterol binding protein-like 3), 유전자 등록번호(Genebank) NM_000169(GLA, Galactosidase, alpha), 유전자 등록번호(Genebank) BC094756(CRA, Myotubularin related protein 11), 유전자 등록번호(Genebank) AB043587(ACBD3, Acyl-Coenzyme A binding domain containing 3), 유전자 등록번호(Genebank) NM_001478[GALGT, UDP-N-acetyl-alpha-D-galactosamine:(N- acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase(GalNAc-T)], 유전자 등록번호(Genebank) J05428(UGT2B7, UDP glucuronosyltransferase 2 family, polypeptide B7), 유전자 등록번호(Genebank) AB002454(CYP4F3, Cytochrome P450, family 4, subfamily F, polypeptide 3), 유전자 등록번호(Genebank) NM_000405(GM2A, GM2 ganglioside activator), 유전자 등록번호(Genebank) BC001823(PRKAB1, Protein kinase, AMP-activated, beta 1 non-catalytic subunit), 유전자 등록번호(Genebank) NM_145343(APOL1, Apolipoprotein L, 1), 유전자 등록번호(Genebank) NM_006571(DCTN6, Dynactin 6), 유전자 등록번호(Genebank) NM_020139(DHRS6, Dehydrogenase/reductase(SDR family) member 6), 유전자 등록번호(Genebank) NM_000499(CYP1A1, Cytochrome P450, family 1, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) BC007003[TGM4, Transglutaminase 4(prostate)], 유전자 등록번호(Genebank) NM_012189[CABYR, Calcium binding tyrosine-(Y)-phosphorylation regulated(fibrousheathin 2)], 유전자 등록번호(Genebank) CR615530(CYGB, Cytoglobin), 유전자 등록번호(Genebank) NM_004199(P4HA2, Procollagen-proline, 2-oxoglutarate 4-dioxygenase(proline 4-hydroxylase), alpha polypeptide II), 유전자 등록번호(Genebank) AK027560(CYP26A1, Cytochrome P450, family 26, subfamily A, polypeptide 1), 유전자 등록번호(Genebank) NM_145298(APOBEC3F, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F), 유전자 등록번호(Genebank) NM_005576(LOXL1, Lysyl oxidase-like 1), 유전자 등록번호(Genebank) AK024854[APOBEC3B, Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D(putative)], 유전자 등록번호(Genebank) NM_014301(NIFUN, NifU-like N-terminal domain containing), 유전자 등록번호(Genebank) BF670653(MB, Myoglobin), 유전자 등록번호(Genebank) AK126982(LHX6, LIM homeobox 6), 유전자 등록번호(Genebank) Y13786[ADAM19, ADAM metallopeptidase domain 19(meltrin beta)], 유전자 등록번호(Genebank) AB051455(MICAL-L1, MICAL-like 1), 유전자 등록번호(Genebank) AK074068(MICAL-L2, MICAL-like 2), 유전자 등록번호(Genebank) AK124421[CPA1, Carboxypeptidase A1(pancreatic)], 유전자 등록번호(Genebank) NM_030622(CYP2S1, Cytochrome P450, family 2, subfamily S, polypeptide 1), 유전자 등록번호(Genebank) BC012027(CYP2U1, Cytochrome P450, family 2, subfamily U, polypeptide 1), 유전자 등록번호(Genebank) AY461717(ZNF385, Zinc finger protein 385), 유전자 등록번호(Genebank) AK092424(ZSCAN4, Zinc finger and SCAN domain containing 4), 유전자 등록번호(Genebank) AB208935[RASAL1, RAS protein activator like 1(GAP1 like)], 유전자 등록번호(Genebank) NM_201444(DGKA, Diacylglycerol kinase, alpha 80kDa), 유전자 등록번호(Genebank) BC035625[EGR2, Early growth response 2(Krox-20 homolog, Drosophila)], 유전자 등록번호(Genebank) BF983391(RPS27L, Ribosomal protein S27-like), 유전자 등록번호(Genebank) BC036545(PLAC2, Placenta-specific 2), 유전자 등록번호(Genebank) BC034569(ZNF337, Zinc finger protein 337), 유전자 등록번호(Genebank) CR936707(TRIM38, Tripartite motif-containing 38), 유전자 등록번호(Genebank) AK091940(MGC4734, Ring finger protein 183), 유전자 등록번호(Genebank) NM_024101(MLPH, Melanophilin), 유전자 등록번호(Genebank) CR601823(HIVEP3, Human immunodeficiency virus type I enhancer binding protein 3), 유전자 등록번호(Genebank) BC041578(MGC17986, zinc finger protein 114), 유전자 등록번호(Genebank) BC038432(RARA, Retinoic acid receptor, alpha), 유전자 등록번호(Genebank) BX641053(FXYD2, FXYD domain containing ion transport regulator 2), 유전자 등록번호(Genebank) AK095363(AQP3, Aquaporin 3), 유전자 등록번호(Genebank) AK074100(SLC37A2, Solute carrier family 37(glycerol-3-phosphate transporter), member 2), 유전자 등록번호(Genebank) AK024002(TUBA4, Tubulin, alpha 4), 유전자 등록번호(Genebank) AK092677(TUBB6, Tubulin, beta 6), 유전자 등록번호(Genebank) NM_001297(CNGB1, Cyclic nucleotide gated channel beta 1), 유전자 등록번호(Genebank) NM_032872(SYTL1, Synaptotagmin-like 1), 유전자 등록번호(Genebank) NM_014045(LRP10, Low density lipoprotein receptor-related protein 10), 유전자 등록번호(Genebank) NM_014585(SLC40A1, Solute carrier family 40(iron-regulated transporter), member 1), 유전자 등록번호(Genebank) L02870[COL7A1, Collagen, type VII, alpha 1(epidermolysis bullosa, dystrophic, dominant and recessive)], 유전자 등록번호(Genebank) AK054731[TUBA1, Tubulin, alpha 1(testis specific)], 유전자 등록번호(Genebank) AF336127(SLC4A11, Solute carrier family 4, sodium bicarbonate transporter-like, member 11), 유전자 등록번호(Genebank) AB075951(SLC22A2, Solute carrier family 22(organic cation transporter), member 2), 유전자 등록번호(Genebank) AK125026(SLC6A12, Solute carrier family 6(neurotransmitter transporter, betaine/GABA), member 12), 유전자 등록번호(Genebank) BX537541(MGC13186, Chromosome 1 open reading frame 57), 유전자 등록번호(Genebank) CD013956(SHBG, Sex hormone-binding globulin), 유전자 등록번호(Genebank) BC029057(DAO, D-amino-acid oxidase), 유전자 등록번호(Genebank) BC041479(COL9A2, Collagen, type IX, alpha 2), 유전자 등록번호(Genebank) AL050210(LOC283130, Hypothetical protein LOC283130), 유전자 등록번호(Genebank) NM_004798(KIF3B, Kinesin family member 3B), 유전자 등록번호(Genebank) AK025742[UCP2, Uncoupling protein 2(mitochondrial, proton carrier)], 유전자 등록번호(Genebank) NM_021990(GABRE, Gamma-aminobutyric acid(GABA) A receptor, epsilon), 유전자 등록번호(Genebank) NM_005819(STX6, Syntaxin 6), 유전자 등록번호(Genebank) BC092420[CYP4F11, Similar to Cytochrome P450 4F12(CYPIVF12)(UNQ568/PRO1129)], 유전자 등록번호(Genebank) BC043423(ABCB6, ATP-binding cassette, sub-family B(MDR/TAP), member 6), 유전자 등록번호(Genebank) BC021025(CTHRC1, Collagen triple helix repeat containing 1), 유전자 등록번호(Genebank) NM_004999(MYO6, Myosin VI), 유전자 등록번호(Genebank) AF445025(SLC35A4, Solute carrier family 35, member A4), 유전자 등록번호(Genebank) NM_003330(TXNRD1, Thioredoxin reductase 1), 유전자 등록번호(Genebank) AK092512(SLC16A5, Solute carrier family 16(monocarboxylic acid transporters), member 5), 유전자 등록번호(Genebank) AB075871[FLJ42654, Golgi transport 1 homolog A(S. cerevisiae)], 유전자 등록번호(Genebank) NM_004864(GDF15, Growth differentiation factor 15), 유전자 등록번호(Genebank) NM_022153(PP2135, Chromosome 10 open reading frame 54), 유전자 등록번호(Genebank) NM_001013632(LOC343521, Similar to hypothetical protein 4833401D15), 유전자 등록번호(Genebank) AK124751(CAPN2, Calpain 2,(m/II) large subunit), 유전자 등록번호(Genebank) AK095079(RGC32, Response gene to complement 32), 유전자 등록번호(Genebank) NM_031286(SH3BGRL3, SH3 domain binding glutamic acid-rich protein like 3), 유전자 등록번호(Genebank) AK126182(KIAA1949, KIAA1949), 유전자 등록번호(Genebank) NM_080388(S100A16, S100 calcium binding protein A16), 유전자 등록번호(Genebank) NM_025106(SSB1, SplA/ryanodine receptor domain and SOCS box containing 1), 유전자 등록번호(Genebank) NM_203403(C9orf150, Chromosome 9 open reading frame 150), 유전자 등록번호(Genebank) AK096241(SQSTM1, Sequestosome 1), 유전자 등록번호(Genebank) BQ276852(TMSB10, Thymosin, beta 10), 유전자 등록번호(Genebank) BC101655(HIST1H2BI, Histone 1, H2bi), 유전자 등록번호(Genebank) W84524(TM4SF5, Transmembrane 4 L six family member 5) 및 유전자 등록번호(Genebank) BX647290(HIST1H2BO, Histone 1, H2bo).
- 제 1항에 있어서, 하기 유전자가 크라이센의 노출에 의해 발현이 감소하는 것을 특징으로 하는 바이오마커:유전자 등록번호(Genebank) NM_002467[MYC, V-myc myelocytomatosis viral oncogene homolog(avian)], 유전자 등록번호(Genebank) BC038295(MAP2K7, Mitogen-activated protein kinase kinase 7), 유전자 등록번호(Genebank) NM_004364(CEBPA, CCAAT/enhancer binding protein(C/EBP), alpha), 유전자 등록번호(Genebank) NM_145161(MAP2K5,Mitogen-activated protein kinase kinase 5), 유전자 등록번호(Genebank) XM_042066(MAP3K1, Mitogen-activated protein kinase kinase kinase 1), 유전자 등록번호(Genebank) Z25424(MKNK2, MAP kinase interacting serine/threonine kinase 2), 유전자 등록번호(Genebank) AB209047(ELK1, ELK1, member of ETS oncogene family), 유전자 등록번호(Genebank) NM_004755(RPS6KA5, Ribosomal protein S6 kinase, 90kDa, polypeptide 5), 유전자 등록번호(Genebank) AB001872(RPL4, Mitogen-activated protein kinase kinase kinase 13), 유전자 등록번호(Genebank) NM_002758(MAP2K6, Mitogen-activated protein kinase kinase 6), 유전자 등록번호(Genebank) AK098095(BRAF, V-raf murine sarcoma viral oncogene homolog B1), 유전자 등록번호(Genebank) AB208919[FGFR1, Fibroblast growth factor receptor 1(fms-related tyrosine kinase 2, Pfeiffer syndrome)], 유전자 등록번호(Genebank) BC060837(DUSP9, Dual specificity phosphatase 9), 유전자 등록번호(Genebank) NM_000142[FGFR3, Fibroblast growth factor receptor 3(achondroplasia, thanatophoric dwarfism)], 유전자 등록번호(Genebank) AY247738[TRIB3, Tribbles homolog 3(Drosophila)], 유전자 등록번호(Genebank) NM_030640(DUSP16, Dual specificity phosphatase 16), 유전자 등록번호(Genebank) NM_148957(TNFRSF19, Tumor necrosis factor receptor superfamily, member 19), 유전자 등록번호(Genebank) AB011123(TNIK, TRAF2 and NCK interacting kinase), 유전자 등록번 호(Genebank) NM_006549(CAMKK2, Calcium/calmodulin-dependent protein kinase kinase 2, beta), 유전자 등록번호(Genebank) NM_022740(HIPK2, Homeodomain interacting protein kinase 2), 유전자 등록번호(Genebank) NM_005400(PRKCE, Protein kinase C, epsilon), 유전자 등록번호(Genebank) NM_000893(KNG1, Kininogen 1), 유전자 등록번호(Genebank) NM_000066(C8B, Complement component 8, beta polypeptide), 유전자 등록번호(Genebank) CR749293(PLG, Plasminogen), 유전자 등록번호(Genebank) BC013780(ADORA2A, Adenosine A2a receptor), 유전자 등록번호(Genebank) NM_001012271(BIRC5, Effector cell peptidase receptor 1), 유전자 등록번호(Genebank) NM_003811(TNFSF9, Tumor necrosis factor(ligand) superfamily, member 9), 유전자 등록번호(Genebank) BC050369(E2F1, E2F transcription factor 1), 유전자 등록번호(Genebank) NM_007313(ABL1, V-abl Abelson murine leukemia viral oncogene homolog 1), 유전자 등록번호(Genebank) BX647151(MYBL2, V-myb myeloblastosis viral oncogene homolog(avian)-like 2), 유전자 등록번호(Genebank) NM_004822(NTN1, Netrin 1), 유전자 등록번호(Genebank) BC033694[BCL2L11, BCL2-like 11(apoptosis facilitator)], 유전자 등록번호(Genebank) AB208876(AXIN1, Axin 1), 유전자 등록번호(Genebank) BC051332[F2, Coagulation factor II(thrombin)], 유전자 등록번호(Genebank) AK122614(PPARD, Peroxisome proliferative activated receptor, delta), 유전자 등록번호(Genebank) L78790[ITGB2, Integrin, beta 2(antigen CD18(p95), lymphocyte function-associated antigen 1; macrophage antigen 1(mac-1) beta subunit)], 유전자 등록번호(Genebank) AK223409(BARD1, BRCA1 associated RING domain 1), 유전자 등록번호(Genebank) NM_002737(PRKCA, Protein kinase C, alpha), 유전자 등록번호(Genebank) NM_012479(YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide), 유전자 등록번호(Genebank) CR596268[ITGB3BP, Integrin beta 3 binding protein(beta3-endonexin)], 유전자 등록번호(Genebank) NM_003551[NME5, Non-metastatic cells 5, protein expressed in(nucleoside-diphosphate kinase)], 유전자 등록번호(Genebank) NM_013974(DDAH2, Dimethylarginine dimethylaminohydrolase 2), 유전자 등록번호(Genebank) D79987[ESPL1, Extra spindle poles like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_006427(SIVA, CD27-binding(Siva) protein), 유전자 등록번호(Genebank) NM_024900(PHF17, PHD finger protein 17), 유전자 등록번호(Genebank) AB046854(MAGI-3, Membrane associated guanylate kinase, WW and PDZ domain containing 3), 유전자 등록번호(Genebank) AK095578(SPHK1, Sphingosine kinase 1), 유전자 등록번호(Genebank) AK122762(CIDEA, Cell death-inducing DFFA-like effector a), 유전자 등록번호(Genebank) AK092872[ERCC2, Excision repair cross-complementing rodent repair deficiency, complementation group 2(xeroderma pigmentosum D)], 유전자 등록번호(Genebank) NM_006290(TNFAIP3, Tumor necrosis factor, alpha-induced protein 3), 유전자 등록번호(Genebank) NM_000562(C8A, Complement component 8, alpha polypeptide), 유전자 등록번호(Genebank) AK122894(AKT1, V-akt murine thymoma viral oncogene homolog 1), 유전자 등록번호(Genebank) NM_005067[SIAH2, Seven in absentia homolog 2(Drosophila)], 유전자 등록번호(Genebank) NM_203339[CLU, Clusterin(complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)], 유전자 등록번호(Genebank) NM_003376(VEGF, Vascular endothelial growth factor), 유전자 등록번호(Genebank) AK027590(DAPK3, Death-associated protein kinase 3), 유전자 등록번호(Genebank) AK122825(HMGB1, High-mobility group box 1), 유전자 등록번호(Genebank) NM_006904(PRKDC, Protein kinase, DNA-activated, catalytic polypeptide), 유전자 등록번호(Genebank) AK074377(UHRF1, Chromosome 19 open reading frame 31), 유전자 등록번호(Genebank) CR604810(CCNA2, Cyclin A2), 유전자 등록번호(Genebank) AK001720[FLJ10858, Nei endonuclease VIII-like 3(E. coli)], 유전자 등록번호(Genebank) CR600021(HMGB2, High-mobility group box 2), 유전자 등록번호(Genebank) NM_006230(POLD2, Polymerase(DNA directed), delta 2, regulatory subunit 50kDa), 유전자 등록번호(Genebank) NM_018151[RIF1, RAP1 interacting factor homolog(yeast)], 유전자 등록번호(Genebank) BX248766[RAD51L1, RAD51-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) NM_014502[PRP19, PRP19/PSO4 pre-mRNA processing factor 19 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_013975(LIG3, Ligase III, DNA, ATP-dependent), 유전자 등록번호(Genebank) NM_173627(FLJ35220, Hypothetical protein FLJ35220), 유전자 등록 번호(Genebank) NM_003362(UNG, Uracil-DNA glycosylase), 유전자 등록번호(Genebank) AF076494(IRF7, Interferon regulatory factor 7), 유전자 등록번호(Genebank) CR625391(RAD51AP1, RAD51 associated protein 1), 유전자 등록번호(Genebank) NM_006231(POLE, Polymerase(DNA directed), epsilon), 유전자 등록번호(Genebank) NM_130398(EXO1, Exonuclease 1), 유전자 등록번호(Genebank) DQ140356(KIAA1596, Fanconi anemia, complementation group M), 유전자 등록번호(Genebank) NM_002105(H2AFX, H2A histone family, member X), 유전자 등록번호(Genebank) AB209560(POLD1, Polymerase(DNA directed), delta 1, catalytic subunit 125kDa), 유전자 등록번호(Genebank) NM_000136(FANCC, Fanconi anemia, complementation group C), 유전자 등록번호(Genebank) NM_003368(USP1, Ubiquitin specific peptidase 1), 유전자 등록번호(Genebank) NM_022836[DCLRE1B, DNA cross-link repair 1B(PSO2 homolog, S. cerevisiae)], 유전자 등록번호(Genebank) NM_001067(TOP2A, Topoisomerase(DNA) II alpha 170kDa), 유전자 등록번호(Genebank) NM_002913(RFC1, Replication factor C(activator 1) 1, 145kDa), 유전자 등록번호(Genebank) NM_002412(MGMT, O-6-methylguanine-DNA methyltransferase), 유전자 등록번호(Genebank) NM_000251[MSH2, MutS homolog 2, colon cancer, nonpolyposis type 1(E. coli)], 유전자 등록번호(Genebank) NM_015254(KIF13B,Kinesin family member 13B), 유전자 등록번호(Genebank) NM_006037(HDAC4, Histone deacetylase 4), 유전자 등록번호(Genebank) NM_020995(HPR, Haptoglobin-related protein), 유전자 등록번호(Genebank) NM_153443(KIR3DL1, Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1), 유전자 등록번호(Genebank) BC071718(CCL4L1, Chemokine(C-C motif) ligand 4-like 1), 유전자 등록번호(Genebank) NM_020979(APS, Adaptor protein with pleckstrin homology and src homology 2 domains), 유전자 등록번호(Genebank) NM_001629(ALOX5AP, Arachidonate 5-lipoxygenase-activating protein), 유전자 등록번호(Genebank) NM_130852(PLUNC, Palate, lung and nasal epithelium carcinoma associated), 유전자 등록번호(Genebank) AK024499(SPON2, Spondin 2, extracellular matrix protein), 유전자 등록번호(Genebank) BC048198(AHSG, Alpha-2-HS-glycoprotein), 유전자 등록번호(Genebank) AK095849(RNU22, RNA, U22 small nucleolar), 유전자 등록번호(Genebank) BC005395(HPX, Hemopexin), 유전자 등록번호(Genebank) NM_012276(ILT7, Leukocyte immunoglobulin-like receptor, subfamily A(with TM domain), member 4), 유전자 등록번호(Genebank) NM_003152(STAT5A, Signal transducer and activator of transcription 5A), 유전자 등록번호(Genebank) BC037171(CCL27, Chemokine(C-C motif) ligand 27), 유전자 등록번호(Genebank) NM_002468[MYD88, Myeloid differentiation primary response gene(88)], 유전자 등록번호(Genebank) NM_002215(ITIH1, Inter-alpha(globulin) inhibitor H1), 유전자 등록번호(Genebank) NM_004750(CRLF1, Cytokine receptor-like factor 1), 유전자 등록번호(Genebank) DR004094(HAMP, Hepcidin antimicrobial peptide), 유전자 등록번호(Genebank) BC063245(GNLY, Granulysin), 유전자 등록번호(Genebank) AJ290445(SARM1, Sterile alpha and TIR motif containing 1), 유전자 등록번호(Genebank) AK122686[IF, I factor(complement)], 유전자 등록번호(Genebank) AB008535(GPR44, G protein-coupled receptor 44), 유전자 등록번호(Genebank) AK122912(ZGPAT, Zinc finger, CCCH-type with G patch domain), 유전자 등록번호(Genebank) BC022312(C4BPA, Complement component 4 binding protein, alpha), 유전자 등록번호(Genebank) BG564683(ORM1, Orosomucoid 1), 유전자 등록번호(Genebank) NM_000625[NOS2A, Nitric oxide synthase 2A(inducible, hepatocytes)], 유전자 등록번호(Genebank) NM_005515(HLXB9, Homeo box HB9), 유전자 등록번호(Genebank) BX537504(C2, Complement component 2), 유전자 등록번호(Genebank) BC028153(LILRB3, Leukocyte immunoglobulin-like receptor, subfamily B(with TM and ITIM domains), member 3), 유전자 등록번호(Genebank) AF130100(SERPINC1, Serpin peptidase inhibitor, clade C(antithrombin), member 1), 유전자 등록번호(Genebank) BC015110(HHEX, Hematopoietically expressed homeobox), 유전자 등록번호(Genebank) AB209179[PLK1, Polo-like kinase 1(Drosophila)], 유전자 등록번호(Genebank) AY367065[ASPM, Asp(abnormal spindle)-like, microcephaly associated(Drosophila)], 유전자 등록번호(Genebank) NM_006101(KNTC2, Kinetochore associated 2), 유전자 등록번호(Genebank) NM_003550[MAD1L1, MAD1 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_020242(KNSL7, Kinesin family member 15), 유전자 등록번호(Genebank) AB033068[FZR1, Fizzy/cell division cycle 20 related 1(Drosophila)], 유전자 등록번호(Genebank) NM_018492(PBK, PDZ binding kinase), 유전자 등록번호(Genebank) NM_003318(TTK, TTK protein kinase), 유전자 등록번호(Genebank) BC011000(CDCA5, Cell division cycle associated 5), 유전자 등록번호(Genebank) NM_003981(PRC1, Protein regulator of cytokinesis 1), 유전자 등록번호(Genebank) NM_015097(CLASP2, Cytoplasmic linker associated protein 2), 유전자 등록번호(Genebank) U65410[MAD2L1, MAD2 mitotic arrest deficient-like 1(yeast)], 유전자 등록번호(Genebank) NM_016343[CENPF, Centromere protein F, 350/400ka(mitosin)], 유전자 등록번호(Genebank) NM_005504(BCAT1, Branched chain aminotransferase 1, cytosolic), 유전자 등록번호(Genebank) NM_003718[CDC2L5, Cell division cycle 2-like 5(cholinesterase-related cell division controller)], 유전자 등록번호(Genebank) NM_002768(PCOLN3, Procollagen(type III) N-endopeptidase), 유전자 등록번호(Genebank) BC004352(KIF22, Kinesin family member 22), 유전자 등록번호(Genebank) NM_005983(SKP2, S-phase kinase-associated protein 2(p45)], 유전자 등록번호(Genebank) NM_004523(KIF11, Kinesin family member 11), 유전자 등록번호(Genebank) CR592757[BRRN1, Barren homolog 1(Drosophila)], 유전자 등록번호(Genebank) NM_019063(EML4, Echinoderm microtubule associated protein like 4), 유전자 등록번호(Genebank) NM_006845(KIF2C, Kinesin family member 2C), 유전자 등록번호(Genebank) NM_004701(CCNB2, Cyclin B2), 유전자 등록번호(Genebank) NM_138555(KIF23, Kinesin family member 23), 유전자 등록번 호(Genebank) NM_182687(PKMYT1, Protein kinase, membrane associated tyrosine/threonine 1), 유전자 등록번호(Genebank) NM_001790(CDC25C, Cell division cycle 25C), 유전자 등록번호(Genebank) BC032677(UBE2C, Ubiquitin-conjugating enzyme E2C), 유전자 등록번호(Genebank) NM_005886(KATNB1, Katanin p80(WD repeat containing) subunit B 1), 유전자 등록번호(Genebank) BC073878(KIFC1, Kinesin family member C1), 유전자 등록번호(Genebank) AL833191[SMC2L1, SMC2 structural maintenance of chromosomes 2-like 1(yeast)], 유전자 등록번호(Genebank) AF053305[BUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog(yeast)], 유전자 등록번호(Genebank) Z25431(NEK1, NIMA(never in mitosis gene a)-related kinase 1), 유전자 등록번호(Genebank) BC043371[GFI1B, Growth factor independent 1B(potential regulator of CDKN1A, translocated in CML)], 유전자 등록번호(Genebank) CR933728(CDC2, Cell division cycle 2, G1 to S and G2 to M), 유전자 등록번호(Genebank) NM_014750[DLG7, Discs, large homolog 7(Drosophila)], 유전자 등록번호(Genebank) NM_018560(WWOX, WW domain containing oxidoreductase), 유전자 등록번호(Genebank) BG203702(FHIT, Nasopharyngeal carcinoma, down-regulated 1), 유전자 등록번호(Genebank) BC050384[SUPT3H, Suppressor of Ty 3 homolog(S. cerevisiae)], 유전자 등록번호(Genebank) NM_000189(HK2, Hexokinase 2), 유전자 등록번호(Genebank) CD049340(AURKB, Aurora kinase B), 유전자 등록번호(Genebank) AB011153[PLCB1, Phospholipase C, beta 1(phosphoinositide- specific)], 유전자 등록번호(Genebank) AB209271(ERF, Ets2 repressor factor), 유전자 등록번호(Genebank) NM_014264[PLK4, Polo-like kinase 4(Drosophila)], 유전자 등록번호(Genebank) NM_002417(MKI67, Antigen identified by monoclonal antibody Ki-67), 유전자 등록번호(Genebank) XM_496557(RGP1, Plasminogen-like B2), 유전자 등록번호(Genebank) NM_170715(RASSF1, Ras association(RalGDS/AF-6) domain family 1), 유전자 등록번호(Genebank) NM_004526[MCM2, MCM2 minichromosome maintenance deficient 2, mitotin(S. cerevisiae)], 유전자 등록번호(Genebank) BC033086[TCF19, Transcription factor 19(SC1)], 유전자 등록번호(Genebank) NM_001007071(RPS6KB2, Ribosomal protein S6 kinase, 70kDa, polypeptide 2), 유전자 등록번호(Genebank) NM_016272(TOB2, Transducer of ERBB2, 2), 유전자 등록번호(Genebank) AK126688(CDYL2, Chromodomain protein, Y-like 2), 유전자 등록번호(Genebank) NM_001759(CCND2, Cyclin D2), 유전자 등록번호(Genebank) NM_002388[MCM3, MCM3 minichromosome maintenance deficient 3(S. cerevisiae)], 유전자 등록번호(Genebank) NM_182776[MCM7, MCM7 minichromosome maintenance deficient 7(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012145[DTYMK, Deoxythymidylate kinase(thymidylate kinase)], 유전자 등록번호(Genebank) NM_014751(MTSS1, Metastasis suppressor 1), 유전자 등록번호(Genebank) NM_024342(GRLF1, Glucocorticoid receptor DNA binding factor 1), 유전자 등록번호(Genebank) AK025627(CABLES1, Cdk5 and Abl enzyme substrate 1), 유전자 등록번호(Genebank) NM_005915[MCM6, MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe)(S. cerevisiae)], 유전자 등록번호(Genebank) AF196185[PARD3, Par-3 partitioning defective 3 homolog(C. elegans)], 유전자 등록번호(Genebank) NM_019001(XRN1, 5'-3' exoribonuclease 1), 유전자 등록번호(Genebank) NM_006739[MCM5, MCM5 minichromosome maintenance deficient 5, cell division cycle 46(S. cerevisiae)], 유전자 등록번호(Genebank) NM_012218(ILF3, Interleukin enhancer binding factor 3, 90kDa), 유전자 등록번호(Genebank) AB053172(CDT1, DNA replication factor), 유전자 등록번호(Genebank) AK074112(CCNL2, Cyclin L2), 유전자 등록번호(Genebank) NM_001005414(ZWINT, ZW10 interactor antisense), 유전자 등록번호(Genebank) BC033391(PP1665, Glycerophosphodiester phosphodiesterase domain containing 5), 유전자 등록번호(Genebank) NM_000672[ADH6, Alcohol dehydrogenase 6(class V)], 유전자 등록번호(Genebank) NM_004563[PCK2, Phosphoenolpyruvate carboxykinase 2(mitochondrial)], 유전자 등록번호(Genebank) XM_113962(KIAA0650, Structural maintenance of chromosomes flexible hinge domain containing 1), 유전자 등록번호(Genebank) NM_001500(GMDS, GDP-mannose 4,6-dehydratase), 유전자 등록번호(Genebank) NM_002541[OGDH, Oxoglutarate(alpha-ketoglutarate) dehydrogenase(lipoamide)], 유전자 등록번호(Genebank) NM_000298(PKLR, Pyruvate kinase, liver and RBC), 유전자 등록번호(Genebank) NM_005276[GPD1, Glycerol-3-phosphate dehydrogenase 1(soluble)], 유전자 등록번호(Genebank) AB209127(PFKL, Phosphofructokinase, liver), 유전자 등록번호(Genebank) M15943(ADH4, Alcohol dehydrogenase 4(class II), pi polypeptide), 유전자 등록번호(Genebank) NM_000671(ADH5, Alcohol dehydrogenase 5(class III), chi polypeptide), 유전자 등록번호(Genebank) BC026320(OGDHL, Oxoglutarate dehydrogenase-like), 유전자 등록번호(Genebank) NM_009590[AOC2, Amine oxidase, copper containing 2(retina-specific)], 유전자 등록번호(Genebank) BC015797(SLC25A10, Solute carrier family 25(mitochondrial carrier; dicarboxylate transporter), member 10), 유전자 등록번호(Genebank) NM_003748(ALDH4A1, Aldehyde dehydrogenase 4 family, member A1), 유전자 등록번호(Genebank) NM_002108(HAL, Histidine ammonia-lyase), 유전자 등록번호(Genebank) NM_003486(SLC7A5, Solute carrier family 7(cationic amino acid transporter, y+ system), member 5), 유전자 등록번호(Genebank) NM_003045(SLC7A1, Solute carrier family 7(cationic amino acid transporter, y+ system), member 1), 유전자 등록번호(Genebank) NM_000277(PAH, Phenylalanine hydroxylase), 유전자 등록번호(Genebank) NM_012331(MSRA, Methionine sulfoxide reductase A), 유전자 등록번호(Genebank) BC008366[DDC, Dopa decarboxylase(aromatic L-amino acid decarboxylase)], 유전자 등록번호(Genebank) NM_006567[FARS2, Phenylalanine-tRNA synthetase 2(mitochondrial)], 유전자 등록번호(Genebank) AK055862(FLJ31300, Urocanase domain containing 1), 유전자 등록번호(Genebank) NM_001875(CPS1, Carbamoyl-phosphate synthetase 1, mitochondrial), 유전자 등록번호(Genebank) AK122685(GLUD1, Glutamate dehydrogenase 1), 유전자 등록번호(Genebank) NM_003046(SLC7A2, Solute carrier family 7(cationic amino acid transporter, y+ system), member 2), 유전자 등록번호(Genebank) AK093306(PHGDH, Phosphoglycerate dehydrogenase), 유전자 등록번호(Genebank) NM_080820(HARS2, Histidyl-tRNA synthetase 2), 유전자 등록번호(Genebank) NM_006907(PYCR1, Pyrroline-5-carboxylate reductase 1), 유전자 등록번호(Genebank) NM_020117(LARS, Leucyl-tRNA synthetase), 유전자 등록번호(Genebank) BC051726[GLUL, Glutamate-ammonia ligase(glutamine synthetase)], 유전자 등록번호(Genebank) BC012616(BHMT, Betaine-homocysteine methyltransferase), 유전자 등록번호(Genebank) AK055053[SHMT2, Serine hydroxymethyltransferase 2(mitochondrial)], 유전자 등록번호(Genebank) NM_007101(SARDH, Sarcosine dehydrogenase), 유전자 등록번호(Genebank) AL833251(LOC283970, Hypothetical protein LOC283970), 유전자 등록번호(Genebank) AK027126(ASS, Argininosuccinate synthetase), 유전자 등록번호(Genebank) L00972(CBS, Cystathionine-beta-synthase), 유전자 등록번호(Genebank) NM_206965(FTCD, Formiminotransferase cyclodeaminase), 유전자 등록번호(Genebank) NM_000429(MAT1A, Methionine adenosyltransferase I, alpha), 유전자 등록번호(Genebank) NM_001801(CDO1, Cysteine dioxygenase, type I), 유전자 등록번호(Genebank) NM_006843(SDS, Serine dehydratase), 유전자 등록번호(Genebank) NM_000170[GLDC, Glycine dehydrogenase(decarboxylating; glycine decarboxylase, glycine cleavage system protein P)], 유전자 등록번호(Genebank) BX102654(HIST1H4B, Histone 1, H4b), 유전자 등록번호(Genebank) DQ097177(UREB1, HECT, UBA and WWE domain containing 1), 유전자 등록번호(Genebank) NM_022743(SMYD3, SET and MYND domain containing 3), 유전자 등록번호(Genebank) NM_001809(CENPA, Centromere protein A, 17kDa), 유전자 등록번호(Genebank) AB028450(NCOR1, Nuclear receptor co-repressor 1), 유전자 등록번호(Genebank) NM_002967(SAFB, Scaffold attachment factor B), 유전자 등록번호(Genebank) NM_003074(SMARCC1, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1), 유전자 등록번호(Genebank) NM_015409(EP400, E1A binding protein p400), 유전자 등록번호(Genebank) BC044659(SMARCA3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3), 유전자 등록번호(Genebank) AB209433(BAT8, Euchromatic histone-lysine N-methyltransferase 2), 유전자 등록번호(Genebank) XM_370756(KIAA1305, KIAA1305), 유전자 등록번호(Genebank) NM_020201(NT5M, 5',3'-nucleotidase, mitochondrial), 유전자 등록번호(Genebank) NM_001025248(DUT, DUTP pyrophosphatase), 유전자 등록번호(Genebank) AK123010(RRM2, Ribonucleotide reductase M2 polypeptide), 유전자 등록번호(Genebank) BX537961(DNMT2, DNA(cytosine-5-)-methyltransferase 2), 유전자 등록번호(Genebank) BX648935(TBL1XR1, Transducin(beta)-like 1X-linked receptor 1), 유전자 등록번호(Genebank) NM_001001888(VCX-C, Variably charged X-C), 유전자 등록번호(Genebank) NM_002501[NFIX, Nuclear factor I/X(CCAAT- binding transcription factor)], 유전자 등록번호(Genebank) NM_003483(HMGA2, High mobility group AT-hook 2), 유전자 등록번호(Genebank) U80628(TK2, Thymidine kinase 2, mitochondrial), 유전자 등록번호(Genebank) NM_006807[CBX1, Chromobox homolog 1(HP1 beta homolog Drosophila )], 유전자 등록번호(Genebank) AY024361(MLL3, Myeloid/lymphoid or mixed-lineage leukemia 3), 유전자 등록번호(Genebank) NM_017519[ARID1B, AT rich interactive domain 1B(SWI1-like)], 유전자 등록번호(Genebank) NM_003077(SMARCD2, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2), 유전자 등록번호(Genebank) NM_016937(POLA, Polymerase(DNA directed), alpha), 유전자 등록번호(Genebank) AJ007583(LARGE, Like-glycosyltransferase), 유전자 등록번호(Genebank) AK124635(PCSK9, Proprotein convertase subtilisin/kexin type 9), 유전자 등록번호(Genebank) NM_030758(OSBP2, Oxysterol binding protein 2), 유전자 등록번호(Genebank) NM_005063[SCD, Stearoyl-CoA desaturase(delta-9-desaturase)], 유전자 등록번호(Genebank) NM_000236(LIPC, Lipase, hepatic), 유전자 등록번호(Genebank) AF288389(GLT25D2, Glycosyltransferase 25 domain containing 2), 유전자 등록번호(Genebank) AF202889(APOA5, Apolipoprotein A-V), 유전자 등록번호(Genebank) BX640945(FADS2, Fatty acid desaturase 2), 유전자 등록번호(Genebank) BI521580(APOC3, Apolipoprotein C-III), 유전자 등록번호(Genebank) NM_001277(CHKA, Choline kinase alpha), 유전자 등록번호(Genebank) Z28339[AKR1D1, Aldo-keto reductase family 1, member D1(delta 4-3-ketosteroid- 5-beta-reductase)], 유전자 등록번호(Genebank) BC035654(NR1H4, Nuclear receptor subfamily 1, group H, member 4), 유전자 등록번호(Genebank) AB209229(MVD, Mevalonate(diphospho) decarboxylase), 유전자 등록번호(Genebank) BC026264(UGT2B4, UDP glucuronosyltransferase 2 family, polypeptide B4), 유전자 등록번호(Genebank) NM_004104(FASN, Fatty acid synthase), 유전자 등록번호(Genebank) NM_147161(THEA, Acyl-CoA thioesterase 11), 유전자 등록번호(Genebank) AF059203(SOAT2, Sterol O-acyltransferase 2), 유전자 등록번호(Genebank) NM_020918(GPAM, Glycerol-3-phosphate acyltransferase, mitochondrial), 유전자 등록번호(Genebank) NM_001443(FABP1, Fatty acid binding protein 1, liver), 유전자 등록번호(Genebank) NM_014762(DHCR24, 24-dehydrocholesterol reductase), 유전자 등록번호(Genebank) AK093328(PCYT2, Phosphate cytidylyltransferase 2, ethanolamine), 유전자 등록번호(Genebank) BX538214(C6orf167, Chromosome 6 open reading frame 167), 유전자 등록번호(Genebank) X75311[MVK, Mevalonate kinase(mevalonic aciduria)], 유전자 등록번호(Genebank) NM_000497(CYP11B1, Cytochrome P450, family 11, subfamily B, polypeptide 1), 유전자 등록번호(Genebank) BC036102(SIAT7F, ST6(alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6), 유전자 등록번호(Genebank) BC012172(ACAS2, Acyl-CoA synthetase short-chain family member 2), 유전자 등록번호(Genebank) NM_007169(PEMT, Phosphatidylethanolamine N-methyltransferase), 유전자 등록번 호(Genebank) X91148(MTP, Microsomal triglyceride transfer protein), 유전자 등록번호(Genebank) NM_198839(ACACA, Acetyl-Coenzyme A carboxylase alpha), 유전자 등록번호(Genebank) NM_004687(MTMR4, Myotubularin related protein 4), 유전자 등록번호(Genebank) NM_000384[APOB, Apolipoprotein B(including Ag(x) antigen)], 유전자 등록번호(Genebank) AK127051[ACAA1, Acetyl-Coenzyme A acyltransferase 1(peroxisomal 3-oxoacyl-Coenzyme A thiolase)], 유전자 등록번호(Genebank) BC035638[LSS, Lanosterol synthase(2,3-oxidosqualene-lanosterol cyclase)], 유전자 등록번호(Genebank) NM_004204(PIGQ, Phosphatidylinositol glycan, class Q), 유전자 등록번호(Genebank) NM_004457(ACSL3, Acyl-CoA synthetase long-chain family member 3), 유전자 등록번호(Genebank) AL138578(ADPN, Adiponutrin), 유전자 등록번호(Genebank) NM_002332[LRP1, Low density lipoprotein-related protein 1(alpha-2-macroglobulin receptor)], 유전자 등록번호(Genebank) NM_016372(GPR175, G protein-coupled receptor 175), 유전자 등록번호(Genebank) NM_080476[CDC91L1, CDC91 cell division cycle 91-like 1(S. cerevisiae)], 유전자 등록번호(Genebank) AF303134(ALDH8A1, Aldehyde dehydrogenase 8 family, member A1), 유전자 등록번호(Genebank) NM_002130[HMGCS1, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1(soluble)], 유전자 등록번호(Genebank) AK055414[LASS4, LAG1 longevity assurance homolog 4(S. cerevisiae)], 유전자 등록번호(Genebank) NM_022977(ACSL4, Acyl-CoA synthetase long-chain family member 4), 유전자 등록번호(Genebank) NM_004631(LRP8, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor), 유전자 등록번호(Genebank) NM_002573(PAFAH1B3, Platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa), 유전자 등록번호(Genebank) NM_021005(NR2F2, Nuclear receptor subfamily 2, group F, member 2), 유전자 등록번호(Genebank) CR620135(DPEP1, Dipeptidase 1(renal)], 유전자 등록번호(Genebank) NM_002317(LOX, Lysyl oxidase), 유전자 등록번호(Genebank) NM_005949[MT1F, Metallothionein 1F(functional)], 유전자 등록번호(Genebank) AF279145(ANTXR1, Anthrax toxin receptor 1), 유전자 등록번호(Genebank) NM_005588[MEP1A, Meprin A, alpha(PABA peptide hydrolase)], 유전자 등록번호(Genebank) NM_014214(IMPA2, Inositol(myo)-1(or 4)-monophosphatase 2), 유전자 등록번호(Genebank) NM_005940[MMP11, Matrix metallopeptidase 11(stromelysin 3)], 유전자 등록번호(Genebank) AB193259(ACE2, Angiotensin I converting enzyme(peptidyl-dipeptidase A) 2), 유전자 등록번호(Genebank) AF018081(COL18A1, Collagen, type XVIII, alpha 1), 유전자 등록번호(Genebank) M28016(cytochrome b, Human mitochondrial cytochrome b gene, partial cds.), 유전자 등록번호(Genebank) NM_002428[MMP15, Matrix metallopeptidase 15(membrane-inserted)], 유전자 등록번호(Genebank) NM_025074(FRAS1, Fraser syndrome 1), 유전자 등록번호(Genebank) M75106[CPB2, Carboxypeptidase B2(plasma, carboxypeptidase U)], 유전자 등록번호(Genebank) NM_000937(POLR2A, Polymerase(RNA) II(DNA directed) polypeptide A, 220kDa), 유전자 등록번 호(Genebank) NM_005060(RORC, RAR-related orphan receptor C), 유전자 등록번호(Genebank) BC092512(MYRIP, Myosin VIIA and Rab interacting protein), 유전자 등록번호(Genebank) NM_000901(NR3C2, Nuclear receptor subfamily 3, group C, member 2), 유전자 등록번호(Genebank) NM_005392(PHF2, PHD finger protein 2), 유전자 등록번호(Genebank) AK091289(ZNF367, Zinc finger protein 367), 유전자 등록번호(Genebank) NM_014788(TRIM14, Tripartite motif-containing 14), 유전자 등록번호(Genebank) NM_018660(ZNF395, Zinc finger protein 395), 유전자 등록번호(Genebank) AB209755(MLLT10, Myeloid/lymphoid or mixed-lineage leukemia(trithorax homolog, Drosophila); translocated to, 10), 유전자 등록번호(Genebank) AK097472[MAZ, MYC-associated zinc finger protein(purine-binding transcription factor)], 유전자 등록번호(Genebank) NM_020062(SLC2A4RG, SLC2A4 regulator), 유전자 등록번호(Genebank) BX571750(HNF4G, Hepatocyte nuclear factor 4, gamma), 유전자 등록번호(Genebank) NM_021807(SEC8L1, Exocyst complex component 4), 유전자 등록번호(Genebank) NM_006651(CPLX1, Complexin 1), 유전자 등록번호(Genebank) NM_005845(ABCC4, ATP-binding cassette, sub-family C(CFTR/MRP), member 4), 유전자 등록번호(Genebank) NM_006650(CPLX2, Complexin 2), 유전자 등록번호(Genebank) NM_004164(RBP2, Retinol binding protein 2, cellular), 유전자 등록번호(Genebank) NM_021069(ARGBP2, Sorbin and SH3 domain containing 2), 유전자 등록번호(Genebank) NM_201649(SLC6A9, Solute carrier family 6(neurotransmitter transporter, glycine), member 9), 유전자 등록번 호(Genebank) NM_005835(SLC17A2, Solute carrier family 17(sodium phosphate), member 2), 유전자 등록번호(Genebank) AJ315644(SLC2A13, Solute carrier family 2(facilitated glucose transporter), member 13), 유전자 등록번호(Genebank) NM_000340(SLC2A2, Solute carrier family 2(facilitated glucose transporter), member 2), 유전자 등록번호(Genebank) NM_003685[KHSRP, KH-type splicing regulatory protein(FUSE binding protein 2)], 유전자 등록번호(Genebank) BX537382(SLC38A3, Solute carrier family 38, member 3), 유전자 등록번호(Genebank) NM_182964(NAV2, Neuron navigator 2), 유전자 등록번호(Genebank) BX640965(SLC22A3, Solute carrier family 22(extraneuronal monoamine transporter), member 3), 유전자 등록번호(Genebank) AK127255(SNX26, Sorting nexin 26), 유전자 등록번호(Genebank) AY043484(SCN1A, Sodium channel, voltage-gated, type I, alpha), 유전자 등록번호(Genebank) AK074107(C20orf59, Chromosome 20 open reading frame 59), 유전자 등록번호(Genebank) NM_003056(SLC19A1, Solute carrier family 19(folate transporter), member 1), 유전자 등록번호(Genebank) NM_020897(HCN3, Hyperpolarization activated cyclic nucleotide-gated potassium channel 3), 유전자 등록번호(Genebank) AY124771(SLC26A1, Solute carrier family 26(sulfate transporter), member 1), 유전자 등록번호(Genebank) NM_001011554(SLC13A3, Solute carrier family 13(sodium-dependent dicarboxylate transporter), member 3), 유전자 등록번호(Genebank) AK027855(SLC5A6, Solute carrier family 5(sodium-dependent vitamin transporter), member 6), 유전자 등록번호(Genebank) NM_001005747(CACNB4, Calcium channel, voltage-dependent, beta 4 subunit), 유전자 등록번호(Genebank) NM_013277(RACGAP1, Rac GTPase activating protein 1), 유전자 등록번호(Genebank) NM_012340(NFATC2, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), 유전자 등록번호(Genebank) NM_018291(FLJ10986, Hypothetical protein FLJ10986), 유전자 등록번호(Genebank) BC052951(LMNB1, Lamin B1), 유전자 등록번호(Genebank) AK075271[SPTLC2L, Serine palmitoyltransferase, long chain base subunit 2-like(aminotransferase 2)], 유전자 등록번호(Genebank) BI762502(GSTA2, Glutathione S-transferase A2), 유전자 등록번호(Genebank) AK055221(FBXO5, F-box protein 5), 유전자 등록번호(Genebank) XM_372695(LOC390859, PREDICTED: Homo sapiens similar to Chain A, Crystal Structure Of The R463a Mutant Of Human Glutamate Dehydrogenase(LOC390859), mRNA), 유전자 등록번호(Genebank) AB037805[KLHL14, Kelch-like 14(Drosophila)], 유전자 등록번호(Genebank) NM_145061(C13orf3, Chromosome 13 open reading frame 3), 유전자 등록번호(Genebank) AK000643(ASB9, Ankyrin repeat and SOCS box-containing 9), 유전자 등록번호(Genebank) AL133031(MLR1, Transcription factor MLR1), 유전자 등록번호(Genebank) AB091343(C10orf3, Centrosomal protein 55kDa), 유전자 등록번호(Genebank) AY007723(MAL2, Mal, T-cell differentiation protein 2), 유전자 등록번호(Genebank) BC098313(FLJ20641, Hypothetical protein FLJ20641), 유전자 등록번 호(Genebank) BC041882(ATF7IP2, Activating transcription factor 7 interacting protein 2), 유전자 등록번호(Genebank) AK127098(FLJ10706, Chromosome 1 open reading frame 112), 유전자 등록번호(Genebank) BC022255[Spc25, Spindle pole body component 25 homolog(S. cerevisiae)] 및 유전자 등록번호(Genebank) BC026283[APOH, Apolipoprotein H(beta-2-glycoprotein I)].
- 제 1항의 바이오마커 유전자 서열의 전부 또는 일부를 포함하는 올리고뉴클레오티드 또는 그의 상보가닥 올리고뉴클레오티드가 집적된 크라이센에 대한 노출 여부 확인용 DNA 마이크로어레이 칩.
- 1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;2) 단계 1)의 실험군 및 대조군의 RNA를 cDNA로 합성하면서 실험군과 대조군을 각기 다른 형광물질로 표지하는 단계;3) 단계 2)의 각기 다른 형광물질로 표지된 cDNA를 제 4항의 DNA 마이크로어레이칩과 혼성화 시키는 단계;4) 단계 3)의 반응한 DNA 마이크로어레이칩을 분석하는 단계; 및5) 단계 4)의 분석한 데이터에서 제 1항의 바이오마커의 발현 정도를 대조군 과 비교하여 확인하는 단계를 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 5항에 있어서, 단계 1)의 체세포는 인간의 간 또는 간암의 세포 및 조직에서 유래한 세포인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 6항에 있어서, 상기 인간 간암 세포는 HepG2인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 5항에 있어서, 단계 2)의 형광물질은 Cy3, Cy5, FITC(poly L-lysine-fluorescein isothiocyanate), RITC(rhodamine-B-isothiocyanate) 및 로다민(rhodamine)으로 이루어진 군으로부터 선택하여 사용하는 것을 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 1) 실험군인 피검체 유래 인간 체세포와 대조군 체세포에서 RNA를 분리하는 단계;2) 단계 1)의 RNA를 대상으로, 제 1항의 바이오마커 유전자에 상보적이고 바이오마커 유전자를 증폭할 수 있는 프라이머를 사용하여 실시간 RT-PCR(Real-time reverse transcript polymerase chain reaction)을 수행하는 단계; 및3) 단계 2)의 유전자 산물을 대조군과 비교하여 발현 정도를 확인하는 단계를 포함하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 9항에 있어서, 단계 1)의 인간 체세포는 간 또는 간암의 세포 및 조직에서 유래한 세포인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 10항에 있어서, 상기 인간 간암 세포는 HepG2인 것을 특징으로 하는 크라이센에 대한 노출 여부를 확인하기 위해 제 1항의 바이오마커를 검출하는 방법.
- 제 4항의 DNA 마이크로어레이 칩을 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
- 제 12항에 있어서, 인간 간 세포 또는 간암 세포를 추가적으로 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
- 제 1항의 바이오마커 유전자에 상보적이고, 바이오마커 유전자를 증폭할 수 있는 프라이머를 포함하는 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
- 제 14항에 있어서, 프라이머는 서열번호 1 내지 70으로 기재되는 서열로 구성된 군으로부터 선택되는 2개 이상의 정방향 프라이머 및 역방향 프라이머인 것을 특징으로 하는 크라이센에 대한 노출 여부 확인용 키트.
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Cited By (5)
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WO2014046706A1 (en) * | 2012-09-24 | 2014-03-27 | Duke University | Signatures of radiation response |
US10316365B2 (en) | 2008-04-02 | 2019-06-11 | Duke University | Signatures of radiation response |
US10578621B2 (en) | 2014-07-30 | 2020-03-03 | Samsung Electronics Co., Ltd. | Biomarker PNCK for predicting effect of a dual-targeting agent |
WO2021045513A1 (ko) * | 2019-09-05 | 2021-03-11 | (주)에이파마 | 아이티아이에이치원을 특이적으로 인식하는 항체 및 이를 포함하는 내당능 장애가 수반되는 질환의 인슐린 저항성 개선용 약학 조성물 |
WO2021045515A1 (ko) * | 2019-09-04 | 2021-03-11 | (주)에이파마 | 아이티아이에이치원의 내당능장애를 수반하는 질환의 인슐린 저항성 검출용 바이오마커로서의 용도 |
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US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
MX2017000527A (es) * | 2014-07-14 | 2017-08-10 | Amgen Inc | Formulaciones de anticuerpos cristalinos. |
GB201611738D0 (en) * | 2016-07-05 | 2016-08-17 | Cambridge Entpr Ltd | Biomarkers for inflammatory bowel disease |
GB201806052D0 (en) | 2018-04-12 | 2018-05-30 | Univ Liverpool | Detection of bacterial infections |
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CN114774546B (zh) * | 2022-04-27 | 2023-04-18 | 江苏省人民医院(南京医科大学第一附属医院) | 一种与人骨肉瘤相关的分子标记物trim22及其应用 |
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KR100671005B1 (ko) | 2004-01-15 | 2007-01-18 | 고려대학교 산학협력단 | Pah 노출 여부 진단용 바이오 마커 단백질 |
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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US10316365B2 (en) | 2008-04-02 | 2019-06-11 | Duke University | Signatures of radiation response |
WO2014046706A1 (en) * | 2012-09-24 | 2014-03-27 | Duke University | Signatures of radiation response |
US10370712B2 (en) | 2012-09-24 | 2019-08-06 | Duke University | Signatures of radiation response |
US10578621B2 (en) | 2014-07-30 | 2020-03-03 | Samsung Electronics Co., Ltd. | Biomarker PNCK for predicting effect of a dual-targeting agent |
WO2021045515A1 (ko) * | 2019-09-04 | 2021-03-11 | (주)에이파마 | 아이티아이에이치원의 내당능장애를 수반하는 질환의 인슐린 저항성 검출용 바이오마커로서의 용도 |
KR20210028588A (ko) * | 2019-09-04 | 2021-03-12 | (주)에이파마 | Itih1의 내당능장애를 수반하는 질환의 인슐린 저항성 검출용 바이오마커로서의 용도 |
WO2021045513A1 (ko) * | 2019-09-05 | 2021-03-11 | (주)에이파마 | 아이티아이에이치원을 특이적으로 인식하는 항체 및 이를 포함하는 내당능 장애가 수반되는 질환의 인슐린 저항성 개선용 약학 조성물 |
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US20090291855A1 (en) | 2009-11-26 |
KR100985090B1 (ko) | 2010-10-04 |
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