JP2017525680A - 結晶性抗体製剤 - Google Patents

結晶性抗体製剤 Download PDF

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Publication number
JP2017525680A
JP2017525680A JP2017502195A JP2017502195A JP2017525680A JP 2017525680 A JP2017525680 A JP 2017525680A JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017502195 A JP2017502195 A JP 2017502195A JP 2017525680 A JP2017525680 A JP 2017525680A
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seq
antibody
sodium
crystals
crystal
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JP2017525680A5 (enExample
Inventor
ナーゼル カーラフ，
ナーゼル カーラフ，
サラスワティ マンダパティ，
サラスワティ マンダパティ，
リーナ ジェイ． パテル，
リーナ ジェイ． パテル，
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Amgen Inc
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Amgen Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2017502195A 2014-07-14 2015-07-13 結晶性抗体製剤 Withdrawn JP2017525680A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462024393P 2014-07-14 2014-07-14
US62/024,393 2014-07-14
PCT/US2015/040217 WO2016010927A1 (en) 2014-07-14 2015-07-13 Crystalline antibody formulations

Related Child Applications (2)

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JP2018091269A Division JP2018150337A (ja) 2014-07-14 2018-05-10 結晶性抗体製剤
JP2020115765A Division JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

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JP2017525680A5 JP2017525680A5 (enExample) 2018-06-21

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JP2018091269A Pending JP2018150337A (ja) 2014-07-14 2018-05-10 結晶性抗体製剤
JP2020115765A Pending JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

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JP2020115765A Pending JP2020172526A (ja) 2014-07-14 2020-07-03 結晶性抗体製剤

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US (2) US20170198059A1 (enExample)
EP (1) EP3169710A1 (enExample)
JP (3) JP2017525680A (enExample)
AU (2) AU2015289874A1 (enExample)
CA (1) CA2954767A1 (enExample)
MX (1) MX2017000527A (enExample)
WO (1) WO2016010927A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017525679A (ja) * 2014-07-14 2017-09-07 アムジェン インコーポレイテッド 結晶性抗体製剤
JP2020535223A (ja) * 2017-09-26 2020-12-03 バイオコン バイオロジックス インディア リミテッドＢｉｏｃｏｎ Ｂｉｏｌｏｇｉｃｓ Ｉｎｄｉａ Ｌｉｍｉｔｅｄ ペプチド結晶の分離、洗浄および乾燥のための統合され、自動化された濾過

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US20170198059A1 (en) * 2014-07-14 2017-07-13 Amgen Inc. Crystalline antibody formulations
US20170056504A1 (en) * 2015-09-02 2017-03-02 Kenneth I. Kohn Method of extending half-life of crystaline antibodies
EP3596101B1 (en) 2017-03-14 2022-01-05 Amgen Inc. Methods directed to crystalline biomolecules
US12103979B2 (en) 2017-04-28 2024-10-01 Amgen Inc. N-acetylated and non-acetylated dipeptides containing arginine to reduce the viscosity of viscous compositions of therapeutic polypeptides
MA48461A (fr) * 2017-04-28 2020-03-04 Amgen Inc Excipients pour réduire la viscosité de formulations d'anticorps et compositions de formulation
GB2584687B (en) * 2019-06-11 2023-08-23 Univ Newcastle Crystallisation of chemical molecules
CN113912622B (zh) 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017525679A (ja) * 2014-07-14 2017-09-07 アムジェン インコーポレイテッド 結晶性抗体製剤
JP2020535223A (ja) * 2017-09-26 2020-12-03 バイオコン バイオロジックス インディア リミテッドＢｉｏｃｏｎ Ｂｉｏｌｏｇｉｃｓ Ｉｎｄｉａ Ｌｉｍｉｔｅｄ ペプチド結晶の分離、洗浄および乾燥のための統合され、自動化された濾過
JP7213254B2 (ja) 2017-09-26 2023-01-26 バイオコン バイオロジックス インディア リミテッド ペプチド結晶の分離、洗浄および乾燥のための統合され、自動化された濾過

Also Published As

Publication number Publication date
AU2021201422A1 (en) 2021-03-25
JP2018150337A (ja) 2018-09-27
US20190127485A1 (en) 2019-05-02
EP3169710A1 (en) 2017-05-24
WO2016010927A1 (en) 2016-01-21
AU2015289874A1 (en) 2017-02-02
US11267902B2 (en) 2022-03-08
JP2020172526A (ja) 2020-10-22
US20170198059A1 (en) 2017-07-13
CA2954767A1 (en) 2016-01-21
MX2017000527A (es) 2017-08-10

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