JP2017525393A5 - - Google Patents
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- JP2017525393A5 JP2017525393A5 JP2017529972A JP2017529972A JP2017525393A5 JP 2017525393 A5 JP2017525393 A5 JP 2017525393A5 JP 2017529972 A JP2017529972 A JP 2017529972A JP 2017529972 A JP2017529972 A JP 2017529972A JP 2017525393 A5 JP2017525393 A5 JP 2017525393A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- reactive
- human
- progenitor
- human ventricular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims description 79
- 210000004027 cell Anatomy 0.000 claims description 77
- 230000002861 ventricular Effects 0.000 claims description 57
- 102000001003 Frizzled-4 Human genes 0.000 claims description 41
- 108050007986 Frizzled-4 Proteins 0.000 claims description 41
- 210000000130 stem cell Anatomy 0.000 claims description 40
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000002243 precursor Substances 0.000 claims description 23
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims description 22
- 230000000747 cardiac effect Effects 0.000 claims description 19
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims description 18
- 108010090448 insulin gene enhancer binding protein Isl-1 Proteins 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000003550 marker Substances 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 238000012258 culturing Methods 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 8
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 8
- 210000005260 human cell Anatomy 0.000 claims description 7
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 6
- 108020001507 fusion proteins Proteins 0.000 claims description 6
- 102000037865 fusion proteins Human genes 0.000 claims description 6
- 210000003716 mesoderm Anatomy 0.000 claims description 6
- 206010048610 Cardiotoxicity Diseases 0.000 claims description 4
- 231100000259 cardiotoxicity Toxicity 0.000 claims description 4
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 210000000056 organ Anatomy 0.000 claims description 4
- 231100000419 toxicity Toxicity 0.000 claims description 4
- 230000001988 toxicity Effects 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 3
- KHZOJCQBHJUJFY-UHFFFAOYSA-N 2-[4-(2-methylpyridin-4-yl)phenyl]-n-(4-pyridin-3-ylphenyl)acetamide Chemical compound C1=NC(C)=CC(C=2C=CC(CC(=O)NC=3C=CC(=CC=3)C=3C=NC=CC=3)=CC=2)=C1 KHZOJCQBHJUJFY-UHFFFAOYSA-N 0.000 claims description 2
- MDZCSIDIPDZWKL-UHFFFAOYSA-N CHIR-98014 Chemical compound C1=C([N+]([O-])=O)C(N)=NC(NCCNC=2N=C(C(=CN=2)N2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1 MDZCSIDIPDZWKL-UHFFFAOYSA-N 0.000 claims description 2
- 208000020446 Cardiac disease Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 108010068426 Contractile Proteins Proteins 0.000 claims description 2
- 101100540419 Danio rerio kdrl gene Proteins 0.000 claims description 2
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims description 2
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims description 2
- 101710107751 Myelin expression factor 2 Proteins 0.000 claims description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 claims description 2
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims description 2
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000002771 cell marker Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000004217 heart function Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 5
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 5
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims 5
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 claims 5
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims 5
- 102000049556 Jagged-1 Human genes 0.000 claims 5
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims 5
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 claims 5
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 5
- 238000012136 culture method Methods 0.000 claims 1
- 102100032702 Protein jagged-1 Human genes 0.000 description 38
- 108700003486 Jagged-1 Proteins 0.000 description 21
- 108700037966 Protein jagged-1 Proteins 0.000 description 21
- 238000004113 cell culture Methods 0.000 description 4
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 description 2
- 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462040892P | 2014-08-22 | 2014-08-22 | |
| US62/040,892 | 2014-08-22 | ||
| US201562194016P | 2015-07-17 | 2015-07-17 | |
| US62/194,016 | 2015-07-17 | ||
| PCT/US2015/046309 WO2016029122A1 (en) | 2014-08-22 | 2015-08-21 | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076020A Division JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525393A JP2017525393A (ja) | 2017-09-07 |
| JP2017525393A5 true JP2017525393A5 (https=) | 2018-08-02 |
| JP6738808B2 JP6738808B2 (ja) | 2020-08-12 |
Family
ID=54062813
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017529972A Active JP6738808B2 (ja) | 2014-08-22 | 2015-08-21 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
| JP2020076020A Pending JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020076020A Pending JP2020120677A (ja) | 2014-08-22 | 2020-04-22 | ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10597637B2 (https=) |
| EP (2) | EP3183337B1 (https=) |
| JP (2) | JP6738808B2 (https=) |
| DK (1) | DK3183337T3 (https=) |
| MA (1) | MA40589A (https=) |
| WO (1) | WO2016029122A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40589A (fr) | 2014-08-22 | 2017-06-28 | Procella Therapeutics Ab | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| DK3417073T3 (da) * | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US20190136191A1 (en) * | 2016-05-02 | 2019-05-09 | Emory University | Methods of Producing Specialized Cardio-Like Cells from Stem Cells |
| EP3519559A1 (en) * | 2016-09-30 | 2019-08-07 | Wisconsin Alumini Research Foundation | Primed cardiac progenitors and methods for making and using same |
| US10508263B2 (en) * | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
| CN109189051A (zh) * | 2018-10-29 | 2019-01-11 | 江苏罗思韦尔电气有限公司 | 一种基于T-Box的故障存储及处理方法 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| CN118159646A (zh) * | 2021-09-13 | 2024-06-07 | 富士胶片细胞动力公司 | 产生定向心脏祖细胞的方法 |
| JP2025512066A (ja) | 2022-04-15 | 2025-04-16 | スマートセラ ソリューションズ エービー | エキソソームを介したｍＲＮＡ剤の送達のための組成物及び方法 |
| GB202314218D0 (en) | 2023-09-18 | 2023-11-01 | Astrazeneca Ab | Cell therapy |
| CN118897089B (zh) * | 2024-08-09 | 2026-02-17 | 山西医科大学 | Sarcolipin在早期无创诊断I型射血分数保留性心衰中的应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| CN1768133A (zh) | 2003-01-31 | 2006-05-03 | 加利福尼亚大学董事会 | 使用islet1作为标志分离或产生干细胞 |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| US20100166714A1 (en) | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2087098A4 (en) | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| WO2008098184A2 (en) | 2007-02-09 | 2008-08-14 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| WO2009017460A1 (en) | 2007-07-31 | 2009-02-05 | Es Cell International Pte Ltd | Method for identifying and selecting cardiomyocytes |
| EP2245140A2 (en) * | 2007-11-30 | 2010-11-03 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US20120027807A1 (en) * | 2008-10-09 | 2012-02-02 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| WO2011091944A1 (en) * | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US20130209415A1 (en) * | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| WO2012162741A1 (en) * | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| JP5920741B2 (ja) | 2012-03-15 | 2016-05-18 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| WO2014078414A1 (en) * | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US10888588B2 (en) | 2013-10-18 | 2021-01-12 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| ES2689804T3 (es) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Composiciones de subpoblaciones de cardiomiocitos |
| EA201691610A8 (ru) * | 2014-02-12 | 2018-05-31 | Дженентек, Инк. | Анти-jagged1 антитела и способы применения |
| JP5924750B2 (ja) * | 2014-05-01 | 2016-05-25 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | Ｃｄ８２陽性心筋前駆細胞 |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| MA40589A (fr) | 2014-08-22 | 2017-06-28 | Procella Therapeutics Ab | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines |
| HK1248270A1 (zh) | 2015-02-17 | 2018-10-12 | 大学健康网路 | 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法 |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
-
2015
- 2015-08-21 MA MA040589A patent/MA40589A/fr unknown
- 2015-08-21 JP JP2017529972A patent/JP6738808B2/ja active Active
- 2015-08-21 EP EP15759585.1A patent/EP3183337B1/en active Active
- 2015-08-21 DK DK15759585.1T patent/DK3183337T3/en active
- 2015-08-21 WO PCT/US2015/046309 patent/WO2016029122A1/en not_active Ceased
- 2015-08-21 US US14/832,324 patent/US10597637B2/en active Active
- 2015-08-21 EP EP18211720.0A patent/EP3524673A1/en active Pending
-
2020
- 2020-04-22 JP JP2020076020A patent/JP2020120677A/ja active Pending
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