JP2020531028A5 - - Google Patents
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- JP2020531028A5 JP2020531028A5 JP2020511361A JP2020511361A JP2020531028A5 JP 2020531028 A5 JP2020531028 A5 JP 2020531028A5 JP 2020511361 A JP2020511361 A JP 2020511361A JP 2020511361 A JP2020511361 A JP 2020511361A JP 2020531028 A5 JP2020531028 A5 JP 2020531028A5
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- Prior art keywords
- cells
- human
- nrp1
- reactive
- agent
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- 238000000034 method Methods 0.000 claims description 118
- 210000000130 stem cell Anatomy 0.000 claims description 68
- 230000002861 ventricular Effects 0.000 claims description 66
- 102000004207 Neuropilin-1 Human genes 0.000 claims description 61
- 108090000772 Neuropilin-1 Proteins 0.000 claims description 61
- 239000003795 chemical substances by application Substances 0.000 claims description 56
- 210000004027 cell Anatomy 0.000 claims description 53
- 210000005260 human cell Anatomy 0.000 claims description 22
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000003550 marker Substances 0.000 claims description 12
- 230000000747 cardiac effect Effects 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000003446 ligand Substances 0.000 claims description 8
- 102100037904 CD9 antigen Human genes 0.000 claims description 4
- 102000000905 Cadherin Human genes 0.000 claims description 4
- 108050007957 Cadherin Proteins 0.000 claims description 4
- 206010048610 Cardiotoxicity Diseases 0.000 claims description 4
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims description 4
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims description 4
- 102100039820 Frizzled-4 Human genes 0.000 claims description 4
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims description 4
- 101000885581 Homo sapiens Frizzled-4 Proteins 0.000 claims description 4
- 101001042362 Homo sapiens Leukemia inhibitory factor receptor Proteins 0.000 claims description 4
- 101000994437 Homo sapiens Protein jagged-1 Proteins 0.000 claims description 4
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 claims description 4
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims description 4
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims description 4
- 102100021747 Leukemia inhibitory factor receptor Human genes 0.000 claims description 4
- 102100032702 Protein jagged-1 Human genes 0.000 claims description 4
- 102000013008 Semaphorin-3A Human genes 0.000 claims description 4
- 108010090319 Semaphorin-3A Proteins 0.000 claims description 4
- 102100038081 Signal transducer CD24 Human genes 0.000 claims description 4
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 4
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 4
- 102100039037 Vascular endothelial growth factor A Human genes 0.000 claims description 4
- 231100000259 cardiotoxicity Toxicity 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 4
- 108020001507 fusion proteins Proteins 0.000 claims description 4
- 102000037865 fusion proteins Human genes 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 4
- 108010090448 insulin gene enhancer binding protein Isl-1 Proteins 0.000 claims description 4
- 231100000419 toxicity Toxicity 0.000 claims description 4
- 230000001988 toxicity Effects 0.000 claims description 4
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 3
- 208000020446 Cardiac disease Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 108010068426 Contractile Proteins Proteins 0.000 claims description 2
- 101100540419 Danio rerio kdrl gene Proteins 0.000 claims description 2
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims description 2
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims description 2
- 101710107751 Myelin expression factor 2 Proteins 0.000 claims description 2
- 101150114527 Nkx2-5 gene Proteins 0.000 claims description 2
- 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims description 2
- 101100460507 Xenopus laevis nkx-2.5 gene Proteins 0.000 claims description 2
- 210000001557 animal structure Anatomy 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000004113 cell culture Methods 0.000 claims description 2
- 239000002771 cell marker Substances 0.000 claims description 2
- 230000004069 differentiation Effects 0.000 claims description 2
- 208000019622 heart disease Diseases 0.000 claims description 2
- 230000004217 heart function Effects 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 208000010125 myocardial infarction Diseases 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000002955 isolation Methods 0.000 description 4
- 238000010187 selection method Methods 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023076094A JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549345P | 2017-08-23 | 2017-08-23 | |
| US62/549,345 | 2017-08-23 | ||
| PCT/IB2018/001026 WO2019038587A1 (en) | 2017-08-23 | 2018-08-22 | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076094A Division JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020531028A JP2020531028A (ja) | 2020-11-05 |
| JP2020531028A5 true JP2020531028A5 (https=) | 2021-09-30 |
| JP7275109B2 JP7275109B2 (ja) | 2023-05-17 |
Family
ID=63794530
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511361A Active JP7275109B2 (ja) | 2017-08-23 | 2018-08-22 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
| JP2023076094A Pending JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023076094A Pending JP2023093754A (ja) | 2017-08-23 | 2023-05-02 | ニューロピリン－１（ｎｒｐ１）のヒト心室前駆細胞を単離するための細胞表面マーカーとしての使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11186820B2 (https=) |
| EP (2) | EP3663393A1 (https=) |
| JP (2) | JP7275109B2 (https=) |
| CN (1) | CN111133099B (https=) |
| CA (1) | CA3072579A1 (https=) |
| DK (1) | DK3487988T3 (https=) |
| WO (1) | WO2019038587A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
| EP4019549B1 (en) | 2019-08-20 | 2025-06-04 | Orizuru Therapeutics, Inc. | Method for enriching cardiac myocytes |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| JP2025512066A (ja) | 2022-04-15 | 2025-04-16 | スマートセラ ソリューションズ エービー | エキソソームを介したｍＲＮＡ剤の送達のための組成物及び方法 |
| CN114752688B (zh) * | 2022-04-28 | 2024-02-23 | 北京大学口腔医学院 | 鉴定人类胚胎骨髓来源的间充质干细胞的方法、探针和试剂盒及其用途 |
| GB202314218D0 (en) | 2023-09-18 | 2023-11-01 | Astrazeneca Ab | Cell therapy |
| CN120699894A (zh) * | 2024-03-25 | 2025-09-26 | 中国科学院分子细胞科学卓越创新中心 | Clusterin阳性心脏类器官及其应用 |
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| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| CN1768133A (zh) | 2003-01-31 | 2006-05-03 | 加利福尼亚大学董事会 | 使用islet1作为标志分离或产生干细胞 |
| DE602005012081D1 (de) | 2005-07-29 | 2009-02-12 | Univ Bonn | Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| US20100166714A1 (en) | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2087098A4 (en) | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| WO2008098184A2 (en) | 2007-02-09 | 2008-08-14 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| WO2009017460A1 (en) | 2007-07-31 | 2009-02-05 | Es Cell International Pte Ltd | Method for identifying and selecting cardiomyocytes |
| EP2245140A2 (en) | 2007-11-30 | 2010-11-03 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US8420620B2 (en) * | 2008-01-24 | 2013-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Induced internalization of surface receptors |
| US20120027807A1 (en) | 2008-10-09 | 2012-02-02 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| WO2010144678A2 (en) | 2009-06-10 | 2010-12-16 | The General Hospital Corporation | Generation of vascularized human heart tissue and uses thereof |
| EP2494032A4 (en) * | 2009-10-29 | 2013-06-05 | Univ Mcmaster | GENERATION OF INDUCED PLURIPOTENTER STEM CELLS AND FIBROBLAST PRECURSOR CELLS |
| WO2011091944A1 (en) | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US20130209415A1 (en) | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| WO2012006503A1 (en) * | 2010-07-09 | 2012-01-12 | Genentech, Inc. | Anti-neuropilin antibodies and methods of use |
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| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
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| KR101323650B1 (ko) * | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 제거방법 |
| WO2012162740A1 (en) | 2011-05-31 | 2012-12-06 | Sonomedical Pty Ltd | Electronic monitoring system for the production of data packages for analytic and diagnostic purposes |
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| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| CN104411331B (zh) * | 2012-01-13 | 2018-08-21 | 哈佛学院董事会 | 在结构聚合装置中tlr激动剂的控制传递 |
| JP5920741B2 (ja) * | 2012-03-15 | 2016-05-18 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| WO2014078414A1 (en) | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US20150079626A1 (en) | 2013-03-19 | 2015-03-19 | Lsip, Llc | Method of obtaining a cell population containing cancer stem cells |
| US10888588B2 (en) | 2013-10-18 | 2021-01-12 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| ES2689804T3 (es) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Composiciones de subpoblaciones de cardiomiocitos |
| WO2015081094A1 (en) * | 2013-11-27 | 2015-06-04 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| EA201691610A8 (ru) | 2014-02-12 | 2018-05-31 | Дженентек, Инк. | Анти-jagged1 антитела и способы применения |
| CA2940691C (en) * | 2014-03-11 | 2022-10-25 | Indiana University Research And Technology Corporation | Method for generating endothelial colony forming cell-like cells |
| JP5924750B2 (ja) * | 2014-05-01 | 2016-05-25 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | Ｃｄ８２陽性心筋前駆細胞 |
| US10144916B2 (en) * | 2014-05-09 | 2018-12-04 | Becton, Dickinson And Company | Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples |
| MA40589A (fr) * | 2014-08-22 | 2017-06-28 | Procella Therapeutics Ab | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| US9765299B2 (en) | 2014-09-10 | 2017-09-19 | Wisconsin Alumni Research Foundation | Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells |
| WO2016089126A1 (ko) * | 2014-12-03 | 2016-06-09 | 사회복지법인 삼성생명공익재단 | 뉴로필린 1(Neuropilin 1)에 대한 항체 및 이의 용도 |
| HK1248270A1 (zh) | 2015-02-17 | 2018-10-12 | 大学健康网路 | 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法 |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
-
2018
- 2018-08-22 WO PCT/IB2018/001026 patent/WO2019038587A1/en not_active Ceased
- 2018-08-22 CN CN201880054988.6A patent/CN111133099B/zh active Active
- 2018-08-22 JP JP2020511361A patent/JP7275109B2/ja active Active
- 2018-08-22 EP EP19210435.4A patent/EP3663393A1/en not_active Withdrawn
- 2018-08-22 DK DK18783080.7T patent/DK3487988T3/da active
- 2018-08-22 US US16/109,218 patent/US11186820B2/en active Active
- 2018-08-22 EP EP18783080.7A patent/EP3487988B1/en active Active
- 2018-08-22 CA CA3072579A patent/CA3072579A1/en active Pending
-
2021
- 2021-10-21 US US17/507,454 patent/US12404488B2/en active Active
-
2023
- 2023-05-02 JP JP2023076094A patent/JP2023093754A/ja active Pending
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