CN111133099B - 神经纤毛蛋白-1(nrp1)作为细胞表面标志物用于分离人心脏心室祖细胞的用途 - Google Patents
神经纤毛蛋白-1(nrp1)作为细胞表面标志物用于分离人心脏心室祖细胞的用途 Download PDFInfo
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- CN111133099B CN111133099B CN201880054988.6A CN201880054988A CN111133099B CN 111133099 B CN111133099 B CN 111133099B CN 201880054988 A CN201880054988 A CN 201880054988A CN 111133099 B CN111133099 B CN 111133099B
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762549345P | 2017-08-23 | 2017-08-23 | |
| US62/549,345 | 2017-08-23 | ||
| PCT/IB2018/001026 WO2019038587A1 (en) | 2017-08-23 | 2018-08-22 | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111133099A CN111133099A (zh) | 2020-05-08 |
| CN111133099B true CN111133099B (zh) | 2023-12-01 |
Family
ID=63794530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880054988.6A Active CN111133099B (zh) | 2017-08-23 | 2018-08-22 | 神经纤毛蛋白-1(nrp1)作为细胞表面标志物用于分离人心脏心室祖细胞的用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11186820B2 (https=) |
| EP (2) | EP3663393A1 (https=) |
| JP (2) | JP7275109B2 (https=) |
| CN (1) | CN111133099B (https=) |
| CA (1) | CA3072579A1 (https=) |
| DK (1) | DK3487988T3 (https=) |
| WO (1) | WO2019038587A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
| EP4019549B1 (en) | 2019-08-20 | 2025-06-04 | Orizuru Therapeutics, Inc. | Method for enriching cardiac myocytes |
| CN113046308A (zh) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法 |
| WO2023278382A1 (en) | 2021-06-29 | 2023-01-05 | Staffan Holmin | Endoluminal delivery cannula |
| JP2025512066A (ja) | 2022-04-15 | 2025-04-16 | スマートセラ ソリューションズ エービー | エキソソームを介したmRNA剤の送達のための組成物及び方法 |
| CN114752688B (zh) * | 2022-04-28 | 2024-02-23 | 北京大学口腔医学院 | 鉴定人类胚胎骨髓来源的间充质干细胞的方法、探针和试剂盒及其用途 |
| GB202314218D0 (en) | 2023-09-18 | 2023-11-01 | Astrazeneca Ab | Cell therapy |
| CN120699894A (zh) * | 2024-03-25 | 2025-09-26 | 中国科学院分子细胞科学卓越创新中心 | Clusterin阳性心脏类器官及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104411331A (zh) * | 2012-01-13 | 2015-03-11 | 哈佛学院董事会 | 在结构聚合装置中tlr激动剂的控制传递 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
| WO2003024462A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
| CN1768133A (zh) | 2003-01-31 | 2006-05-03 | 加利福尼亚大学董事会 | 使用islet1作为标志分离或产生干细胞 |
| DE602005012081D1 (de) | 2005-07-29 | 2009-02-12 | Univ Bonn | Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne |
| US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
| US20100166714A1 (en) | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2087098A4 (en) | 2006-11-09 | 2010-03-31 | Univ Johns Hopkins | DETERMINATION OF CARDIOMYOCYTES ADULT MAMMALS IN HEART STEM CELLS |
| US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
| WO2008098184A2 (en) | 2007-02-09 | 2008-08-14 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
| WO2009017460A1 (en) | 2007-07-31 | 2009-02-05 | Es Cell International Pte Ltd | Method for identifying and selecting cardiomyocytes |
| EP2245140A2 (en) | 2007-11-30 | 2010-11-03 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US8420620B2 (en) * | 2008-01-24 | 2013-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Induced internalization of surface receptors |
| US20120027807A1 (en) | 2008-10-09 | 2012-02-02 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
| WO2010144678A2 (en) | 2009-06-10 | 2010-12-16 | The General Hospital Corporation | Generation of vascularized human heart tissue and uses thereof |
| EP2494032A4 (en) * | 2009-10-29 | 2013-06-05 | Univ Mcmaster | GENERATION OF INDUCED PLURIPOTENTER STEM CELLS AND FIBROBLAST PRECURSOR CELLS |
| WO2011091944A1 (en) | 2010-01-26 | 2011-08-04 | Université Libre de Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
| US20130209415A1 (en) | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
| US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
| WO2012006503A1 (en) * | 2010-07-09 | 2012-01-12 | Genentech, Inc. | Anti-neuropilin antibodies and methods of use |
| AU2010100830A4 (en) | 2010-08-03 | 2010-09-16 | Robert Fallshaw | Biased Pin Lock |
| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| WO2012074116A1 (ja) | 2010-12-02 | 2012-06-07 | 独立行政法人理化学研究所 | アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体(TCR)遺伝子のα鎖領域が均一なVα-Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング |
| WO2012135253A1 (en) * | 2011-03-29 | 2012-10-04 | Geron Corporation | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
| KR101323650B1 (ko) * | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | 미분화 전능성 줄기세포의 제거방법 |
| WO2012162740A1 (en) | 2011-05-31 | 2012-12-06 | Sonomedical Pty Ltd | Electronic monitoring system for the production of data packages for analytic and diagnostic purposes |
| WO2012162741A1 (en) | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
| US8951798B2 (en) | 2011-10-13 | 2015-02-10 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
| JP5920741B2 (ja) * | 2012-03-15 | 2016-05-18 | iHeart Japan株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| WO2014078414A1 (en) | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
| WO2014150602A1 (en) | 2013-03-15 | 2014-09-25 | Fate Therapeutics, Inc. | Cell potency assay for therapeutic potential |
| US20150079626A1 (en) | 2013-03-19 | 2015-03-19 | Lsip, Llc | Method of obtaining a cell population containing cancer stem cells |
| US10888588B2 (en) | 2013-10-18 | 2021-01-12 | Icahn School Of Medicine At Mount Sinai | Directed cardiomyocyte differentiation and ventricular specification of stem cells |
| ES2689804T3 (es) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Composiciones de subpoblaciones de cardiomiocitos |
| WO2015081094A1 (en) * | 2013-11-27 | 2015-06-04 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| EA201691610A8 (ru) | 2014-02-12 | 2018-05-31 | Дженентек, Инк. | Анти-jagged1 антитела и способы применения |
| CA2940691C (en) * | 2014-03-11 | 2022-10-25 | Indiana University Research And Technology Corporation | Method for generating endothelial colony forming cell-like cells |
| JP5924750B2 (ja) * | 2014-05-01 | 2016-05-25 | iHeart Japan株式会社 | Cd82陽性心筋前駆細胞 |
| US10144916B2 (en) * | 2014-05-09 | 2018-12-04 | Becton, Dickinson And Company | Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples |
| MA40589A (fr) * | 2014-08-22 | 2017-06-28 | Procella Therapeutics Ab | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| US9765299B2 (en) | 2014-09-10 | 2017-09-19 | Wisconsin Alumni Research Foundation | Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells |
| WO2016089126A1 (ko) * | 2014-12-03 | 2016-06-09 | 사회복지법인 삼성생명공익재단 | 뉴로필린 1(Neuropilin 1)에 대한 항체 및 이의 용도 |
| HK1248270A1 (zh) | 2015-02-17 | 2018-10-12 | 大学健康网路 | 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法 |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
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2018
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2021
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104411331A (zh) * | 2012-01-13 | 2015-03-11 | 哈佛学院董事会 | 在结构聚合装置中tlr激动剂的控制传递 |
Non-Patent Citations (3)
| Title |
|---|
| Neural crest–derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation;Alice Plein等;The Journal of Clinical Investigation;第125卷(第125期);2661-2676 * |
| NRP1 function and targeting in neurovascular development and eye disease;Claudio Raimondi等;Progress in Retinal and Eye Research;第52卷;63-84 * |
| 诱导多能干细胞和心脏干 /祖细胞对心肌修复作用的研究进展;曾春雨;解放军医药杂志;第24卷(第24期);1-4 * |
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| US20220112458A1 (en) | 2022-04-14 |
| DK3487988T3 (da) | 2020-02-03 |
| WO2019038587A1 (en) | 2019-02-28 |
| JP7275109B2 (ja) | 2023-05-17 |
| CN111133099A (zh) | 2020-05-08 |
| JP2020531028A (ja) | 2020-11-05 |
| JP2023093754A (ja) | 2023-07-04 |
| US12404488B2 (en) | 2025-09-02 |
| EP3663393A1 (en) | 2020-06-10 |
| CA3072579A1 (en) | 2019-02-28 |
| US20190062696A1 (en) | 2019-02-28 |
| EP3487988B1 (en) | 2020-01-01 |
| EP3487988A1 (en) | 2019-05-29 |
| US11186820B2 (en) | 2021-11-30 |
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