DK3487988T3 - Brug af neuropilin-1 (nrp1) som en celleoverflademarkør til isolering af humane hjerte ventrikulære stamceller - Google Patents

Brug af neuropilin-1 (nrp1) som en celleoverflademarkør til isolering af humane hjerte ventrikulære stamceller Download PDF

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DK3487988T3
DK3487988T3 DK18783080.7T DK18783080T DK3487988T3 DK 3487988 T3 DK3487988 T3 DK 3487988T3 DK 18783080 T DK18783080 T DK 18783080T DK 3487988 T3 DK3487988 T3 DK 3487988T3
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nrp1
neuropilin
stem cells
cell surface
human heart
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DK18783080.7T
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Kenneth R Chien
Jonathan Clarke
Chuen Yan Leung
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Procella Therapeutics Ab
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    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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DK18783080.7T 2017-08-23 2018-08-22 Brug af neuropilin-1 (nrp1) som en celleoverflademarkør til isolering af humane hjerte ventrikulære stamceller DK3487988T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762549345P 2017-08-23 2017-08-23
PCT/IB2018/001026 WO2019038587A1 (en) 2017-08-23 2018-08-22 USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS

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DK3487988T3 true DK3487988T3 (da) 2020-02-03

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US (2) US11186820B2 (da)
EP (2) EP3487988B1 (da)
JP (2) JP7275109B2 (da)
CN (1) CN111133099B (da)
CA (1) CA3072579A1 (da)
DK (1) DK3487988T3 (da)
WO (1) WO2019038587A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10596200B2 (en) 2014-08-22 2020-03-24 Procella Therapeutics Ab Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells
PT3417073T (pt) 2016-02-19 2023-10-26 Procella Therapeutics Ab Marcadores genéticos para enxerto de células progenitoras ventriculares cardíacas humanas
US10508263B2 (en) 2016-11-29 2019-12-17 Procella Therapeutics Ab Methods for isolating human cardiac ventricular progenitor cells
US20220298482A1 (en) * 2019-08-20 2022-09-22 Orizuru Therapeutics, Inc. Method for enriching cardiac myocytes
CN113046308A (zh) * 2021-03-05 2021-06-29 苏州大学附属第二医院 促进心脏损伤后修复的一类新型成纤维细胞及其标识方法
US20220409855A1 (en) 2021-06-29 2022-12-29 Staffan Holmin Methods of delivering cells and therapeutic agents to organs and extravascular sites
WO2023199113A1 (en) 2022-04-15 2023-10-19 Smartcella Solutions Ab COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS
CN114752688B (zh) * 2022-04-28 2024-02-23 北京大学口腔医学院 鉴定人类胚胎骨髓来源的间充质干细胞的方法、探针和试剂盒及其用途

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5561384A (en) 1995-11-08 1996-10-01 Advanced Micro Devices, Inc. Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US5945577A (en) 1997-01-10 1999-08-31 University Of Massachusetts As Represented By Its Amherst Campus Cloning using donor nuclei from proliferating somatic cells
US7166280B2 (en) 2000-04-06 2007-01-23 Franco Wayne P Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
CA2465672A1 (en) 2001-09-19 2003-03-27 Henry Ford Health System Cardiac transplantation of stem cells for the treatment of heart failure
US7745113B2 (en) 2003-01-31 2010-06-29 The Regents Of The University Of California Use of islet 1 as a marker for isolating or generating stem cells
US20080038229A1 (en) 2006-08-08 2008-02-14 Minguell Jose J Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium
WO2008054819A2 (en) 2006-11-02 2008-05-08 The General Hospital Corporation Cardiovascular stem cells, methods for stem cell isolation, and uses thereof
EP2087098A4 (en) 2006-11-09 2010-03-31 Univ Johns Hopkins DEDIFFERENTIATION OF ADULT MAMMALIAN CARDIOMYCYTES INTO CARDIAC STEM CELLS
US20080182328A1 (en) 2006-12-19 2008-07-31 The Burnham Institute Mammalian extraembryonic endoderm cells and methods of isolation
WO2008098184A2 (en) 2007-02-09 2008-08-14 The General Hospital Corporation Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof
GB2465502B (en) 2007-07-31 2013-06-26 Es Cell Int Pte Ltd Method for identifying and selecting cardiomyocytes
EP2245140A2 (en) 2007-11-30 2010-11-03 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
US8420620B2 (en) * 2008-01-24 2013-04-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Induced internalization of surface receptors
US20120027807A1 (en) 2008-10-09 2012-02-02 The General Hospital Corporation Tissue engineered myocardium and methods of production and uses thereof
WO2010144678A2 (en) 2009-06-10 2010-12-16 The General Hospital Corporation Generation of vascularized human heart tissue and uses thereof
AU2010312291A1 (en) * 2009-10-29 2012-06-21 Mcmaster University Generating induced pluripotent stem cells and progenitor cells from fibroblasts
WO2011091944A1 (en) 2010-01-26 2011-08-04 Université Libre de Bruxelles Tools for isolating and following cardiovascular progenitor cells
WO2011153236A1 (en) 2010-06-03 2011-12-08 The Board Of Trustees Of The Leland Stanford Junior University Purified compositions of cardiovascular progenitor cells
US20120009158A1 (en) 2010-06-18 2012-01-12 The General Hospital Corporation VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF
MX2013000083A (es) * 2010-07-09 2013-02-26 Genentech Inc Anticuerpos de anti-neuropilina y metodos de uso.
AU2010100830A4 (en) 2010-08-03 2010-09-16 Robert Fallshaw Biased Pin Lock
WO2012070014A2 (en) 2010-11-26 2012-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells
WO2012135253A1 (en) * 2011-03-29 2012-10-04 Geron Corporation Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells
KR101323650B1 (ko) * 2011-05-04 2013-11-05 연세대학교 산학협력단 미분화 전능성 줄기세포의 제거방법
WO2012162741A1 (en) 2011-06-01 2012-12-06 Monash University Enrichment of cardiomyocytes
WO2013056072A1 (en) 2011-10-13 2013-04-18 Wisconsin Alumni Research Foundation Generation of cardiomyocytes from human pluripotent stem cells
WO2013106852A1 (en) * 2012-01-13 2013-07-18 President And Fellows Of Harvard College Controlled delivery of tlr agonists in structural polymeric devices
JP5920741B2 (ja) 2012-03-15 2016-05-18 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法
US9234176B2 (en) 2012-11-13 2016-01-12 The Board Of Trustees Of The Leland Stanford Junior University Chemically defined production of cardiomyocytes from pluripotent stem cells
EP2968416A4 (en) 2013-03-15 2016-08-17 Fate Therapeutics Inc BIOLOGICAL ACTIVITY TESTING OF CELLS FOR A THERAPEUTIC POTENTIAL
WO2015058117A1 (en) * 2013-10-18 2015-04-23 Icahn School Of Medicine At Mount Sinai Directed cardiomyocyte differentiation and ventricular specification of stem cells
EP2875819B1 (en) 2013-11-20 2018-09-19 Miltenyi Biotec GmbH Compositions of cardiomyocyte subpopulations
WO2015081094A1 (en) * 2013-11-27 2015-06-04 University Of Louisville Research Foundation, Inc. Cardiac progenitor cells and methods of use therefor
TW201902515A (zh) 2014-02-12 2019-01-16 美商建南德克公司 抗jagged1抗體及使用方法
EP3964564A1 (en) 2014-03-11 2022-03-09 Indiana University Research and Technology Corporation Method for generating endothelial colony forming cell-like cells
WO2015166638A1 (ja) * 2014-05-01 2015-11-05 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 Ｃｄ８２陽性心筋前駆細胞
US10144916B2 (en) * 2014-05-09 2018-12-04 Becton, Dickinson And Company Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples
US10596200B2 (en) 2014-08-22 2020-03-24 Procella Therapeutics Ab Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells
JP6738808B2 (ja) 2014-08-22 2020-08-12 プロセラ セラピューティクス アーベー ヒト心室前駆体細胞を単離するための細胞表面マーカーとしてのＪａｇｇｅｄ１／Ｆｒｉｚｚｌｅｄ４の使用
US9765299B2 (en) 2014-09-10 2017-09-19 Wisconsin Alumni Research Foundation Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells
EP3783031B1 (en) 2014-12-03 2023-08-02 Aimed Bio Inc. Antibody against neuropilin 1 and use thereof
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
PT3417073T (pt) 2016-02-19 2023-10-26 Procella Therapeutics Ab Marcadores genéticos para enxerto de células progenitoras ventriculares cardíacas humanas
US10508263B2 (en) 2016-11-29 2019-12-17 Procella Therapeutics Ab Methods for isolating human cardiac ventricular progenitor cells

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EP3487988A1 (en) 2019-05-29
EP3487988B1 (en) 2020-01-01
CN111133099A (zh) 2020-05-08
US20220112458A1 (en) 2022-04-14
JP2023093754A (ja) 2023-07-04
JP2020531028A (ja) 2020-11-05
WO2019038587A1 (en) 2019-02-28
US11186820B2 (en) 2021-11-30
CN111133099B (zh) 2023-12-01
CA3072579A1 (en) 2019-02-28
JP7275109B2 (ja) 2023-05-17
EP3663393A1 (en) 2020-06-10
US20190062696A1 (en) 2019-02-28

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