DK3487988T3 - USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE COLLECTOR FOR INSULATING HUMAN HEART VENTRICULAR STEM CELLS - Google Patents
USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE COLLECTOR FOR INSULATING HUMAN HEART VENTRICULAR STEM CELLS Download PDFInfo
- Publication number
- DK3487988T3 DK3487988T3 DK18783080.7T DK18783080T DK3487988T3 DK 3487988 T3 DK3487988 T3 DK 3487988T3 DK 18783080 T DK18783080 T DK 18783080T DK 3487988 T3 DK3487988 T3 DK 3487988T3
- Authority
- DK
- Denmark
- Prior art keywords
- nrp1
- neuropilin
- stem cells
- cell surface
- human heart
- Prior art date
Links
- 102000004207 Neuropilin-1 Human genes 0.000 title 2
- 108090000772 Neuropilin-1 Proteins 0.000 title 2
- 210000004027 cell Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 230000002861 ventricular Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0657—Cardiomyocytes; Heart cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0375—Animal model for cardiovascular diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases (EC 2.)
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pregnancy & Childbirth (AREA)
- Animal Husbandry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762549345P | 2017-08-23 | 2017-08-23 | |
PCT/IB2018/001026 WO2019038587A1 (en) | 2017-08-23 | 2018-08-22 | Use of neuropilin-1 (nrp1) as a cell surface marker for isolating human cardiac ventricular progenitor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3487988T3 true DK3487988T3 (en) | 2020-02-03 |
Family
ID=63794530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18783080.7T DK3487988T3 (en) | 2017-08-23 | 2018-08-22 | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE COLLECTOR FOR INSULATING HUMAN HEART VENTRICULAR STEM CELLS |
Country Status (7)
Country | Link |
---|---|
US (2) | US11186820B2 (en) |
EP (2) | EP3487988B1 (en) |
JP (2) | JP7275109B2 (en) |
CN (1) | CN111133099B (en) |
CA (1) | CA3072579A1 (en) |
DK (1) | DK3487988T3 (en) |
WO (1) | WO2019038587A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
PT3417073T (en) | 2016-02-19 | 2023-10-26 | Procella Therapeutics Ab | Genetic markers for engraftment of human cardiac ventricular progenitor cells |
US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
CN114269900A (en) * | 2019-08-20 | 2022-04-01 | 千纸鹤治疗公司 | Method for enriching cardiac muscle cells |
CN113046308A (en) * | 2021-03-05 | 2021-06-29 | 苏州大学附属第二医院 | Novel fibroblast for promoting repair after heart injury and identification method thereof |
US20220409855A1 (en) | 2021-06-29 | 2022-12-29 | Staffan Holmin | Methods of delivering cells and therapeutic agents to organs and extravascular sites |
US20230330264A1 (en) | 2022-04-15 | 2023-10-19 | Smartcella Solutions Ab | COMPOSITIONS AND METHODS FOR EXOSOME-MEDIATED DELIVERY OF mRNA AGENTS |
CN114752688B (en) * | 2022-04-28 | 2024-02-23 | 北京大学口腔医学院 | Method, probe and kit for identifying mesenchymal stem cells derived from human embryo bone marrow and application thereof |
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US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US5561384A (en) | 1995-11-08 | 1996-10-01 | Advanced Micro Devices, Inc. | Input/output driver circuit for isolating with minimal power consumption a peripheral component from a core section |
US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
US7166280B2 (en) | 2000-04-06 | 2007-01-23 | Franco Wayne P | Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease |
CA2465672A1 (en) | 2001-09-19 | 2003-03-27 | Henry Ford Health System | Cardiac transplantation of stem cells for the treatment of heart failure |
JP2006519015A (en) | 2003-01-31 | 2006-08-24 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | Use of Islet1 as a marker for isolating or generating stem cells |
US20080038229A1 (en) | 2006-08-08 | 2008-02-14 | Minguell Jose J | Intracoronary injection of a mixture of autologous bone marrow derived mononuclear cells and autologous bone marrow derived mesenchymal stem cells for utilization and rescue of infarcted myocardium |
WO2008054819A2 (en) | 2006-11-02 | 2008-05-08 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
WO2008058273A2 (en) | 2006-11-09 | 2008-05-15 | The Johns Hopkins University | Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells |
US20080182328A1 (en) | 2006-12-19 | 2008-07-31 | The Burnham Institute | Mammalian extraembryonic endoderm cells and methods of isolation |
US20110033430A1 (en) | 2007-02-09 | 2011-02-10 | The General Hospital Corporation | Methods for the induction of a cell to enter the islet 1+ lineage and a method for the expansion thereof |
AU2007357127B2 (en) | 2007-07-31 | 2014-06-26 | Es Cell International Pte Ltd | Method for identifying and selecting cardiomyocytes |
EP2245140A2 (en) | 2007-11-30 | 2010-11-03 | New York Medical College | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
WO2009094561A1 (en) * | 2008-01-24 | 2009-07-30 | The Government Of The United States Of America As Represented By The Secretary Of The Departmentof | Induced internalization of surface receptors |
WO2010042856A2 (en) | 2008-10-09 | 2010-04-15 | The General Hospital Corporation | Tissue engineered myocardium and methods of production and uses thereof |
US8765117B2 (en) | 2009-06-10 | 2014-07-01 | The General Hospital Corporation | Generation of vascularized human heart tissue and uses thereof |
JP2013507974A (en) * | 2009-10-29 | 2013-03-07 | マックマスター ユニバーシティー | Preparation of induced pluripotent stem cells and progenitor cells from fibroblasts |
US20120301445A1 (en) | 2010-01-26 | 2012-11-29 | Universite Libre De Bruxelles | Tools for isolating and following cardiovascular progenitor cells |
US20130209415A1 (en) | 2010-06-03 | 2013-08-15 | The Board Of Trustees Of The Leland Stanford Junior University | Purified compositions of cardiovascular progenitor cells |
US20120009158A1 (en) | 2010-06-18 | 2012-01-12 | The General Hospital Corporation | VENTRICULAR INDUCED PLURIPOTENT STEM (ViPS) CELLS FOR GENERATION OF AUTOLOGOUS VENTRICULAR CARDIOMYOCYTES AND USES THEREOF |
BR112013000340A2 (en) | 2010-07-09 | 2016-05-31 | Genentech Inc | isolated antibody that binds neuropillin-1 (nrp1), isolated nucleic acid, host cell, method of producing an antibody, immunoconjugate and method of detecting nrp1 in a biological sample |
AU2010100830A4 (en) | 2010-08-03 | 2010-09-16 | Robert Fallshaw | Biased Pin Lock |
WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
AU2012236707B2 (en) * | 2011-03-29 | 2017-07-20 | Asterias Biotherapeutics, Inc. | Enriched populations of cardiomyocyte lineage cells from pluripotent stem cells |
KR101323650B1 (en) * | 2011-05-04 | 2013-11-05 | 연세대학교 산학협력단 | Methods for Depleting Undifferentiated Pluripotent Stem Cells |
WO2012162741A1 (en) | 2011-06-01 | 2012-12-06 | Monash University | Enrichment of cardiomyocytes |
WO2013056072A1 (en) | 2011-10-13 | 2013-04-18 | Wisconsin Alumni Research Foundation | Generation of cardiomyocytes from human pluripotent stem cells |
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US9764063B2 (en) | 2012-03-15 | 2017-09-19 | Iheart Japan Corporation | Method for producing mixed cell population of cardiomyocytes and vascular cells from induced pluripotent stem cell |
WO2014078414A1 (en) | 2012-11-13 | 2014-05-22 | Joseph Wu | Chemically defined production of cardiomyocytes from pluripotent stem cells |
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ES2689804T3 (en) | 2013-11-20 | 2018-11-15 | Miltenyi Biotec Gmbh | Compositions of subpopulations of cardiomyocytes |
US9987310B2 (en) * | 2013-11-27 | 2018-06-05 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
EP3825332A1 (en) | 2014-02-12 | 2021-05-26 | F. Hoffmann-La Roche AG | Anti-jagged1 antibodies and methods of use |
AU2015229387B2 (en) | 2014-03-11 | 2021-06-24 | Indiana University Research And Technology Corporation | Method for generating endothelial colony forming cell-like cells |
WO2015166638A1 (en) * | 2014-05-01 | 2015-11-05 | iHeart Japan株式会社 | Cd82-positive cardiac progenitor cells |
US10144916B2 (en) * | 2014-05-09 | 2018-12-04 | Becton, Dickinson And Company | Cell surface signature for processing cardiomyocyte subsets from heterogeneous cell samples |
EP3183337B1 (en) | 2014-08-22 | 2019-02-06 | Procella Therapeutics AB | Use of jagged 1/frizzled 4 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
US9765299B2 (en) | 2014-09-10 | 2017-09-19 | Wisconsin Alumni Research Foundation | Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells |
WO2016089126A1 (en) | 2014-12-03 | 2016-06-09 | 사회복지법인 삼성생명공익재단 | Antibody against neuropilin 1 and use thereof |
JP2018510649A (en) * | 2015-02-17 | 2018-04-19 | ユニバーシティー ヘルス ネットワーク | Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular cardiomyocytes |
PT3417073T (en) | 2016-02-19 | 2023-10-26 | Procella Therapeutics Ab | Genetic markers for engraftment of human cardiac ventricular progenitor cells |
US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
-
2018
- 2018-08-22 EP EP18783080.7A patent/EP3487988B1/en active Active
- 2018-08-22 CA CA3072579A patent/CA3072579A1/en active Pending
- 2018-08-22 EP EP19210435.4A patent/EP3663393A1/en not_active Withdrawn
- 2018-08-22 WO PCT/IB2018/001026 patent/WO2019038587A1/en unknown
- 2018-08-22 DK DK18783080.7T patent/DK3487988T3/en active
- 2018-08-22 US US16/109,218 patent/US11186820B2/en active Active
- 2018-08-22 JP JP2020511361A patent/JP7275109B2/en active Active
- 2018-08-22 CN CN201880054988.6A patent/CN111133099B/en active Active
-
2021
- 2021-10-21 US US17/507,454 patent/US20220112458A1/en active Pending
-
2023
- 2023-05-02 JP JP2023076094A patent/JP2023093754A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20220112458A1 (en) | 2022-04-14 |
EP3487988B1 (en) | 2020-01-01 |
US20190062696A1 (en) | 2019-02-28 |
EP3663393A1 (en) | 2020-06-10 |
JP7275109B2 (en) | 2023-05-17 |
US11186820B2 (en) | 2021-11-30 |
JP2020531028A (en) | 2020-11-05 |
JP2023093754A (en) | 2023-07-04 |
CA3072579A1 (en) | 2019-02-28 |
CN111133099B (en) | 2023-12-01 |
WO2019038587A1 (en) | 2019-02-28 |
CN111133099A (en) | 2020-05-08 |
EP3487988A1 (en) | 2019-05-29 |
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