SG10201913687VA - Generation of midbrain-specific organoids from human pluripotent stem cells - Google Patents
Generation of midbrain-specific organoids from human pluripotent stem cellsInfo
- Publication number
- SG10201913687VA SG10201913687VA SG10201913687VA SG10201913687VA SG10201913687VA SG 10201913687V A SG10201913687V A SG 10201913687VA SG 10201913687V A SG10201913687V A SG 10201913687VA SG 10201913687V A SG10201913687V A SG 10201913687VA SG 10201913687V A SG10201913687V A SG 10201913687VA
- Authority
- SG
- Singapore
- Prior art keywords
- midbrain
- generation
- stem cells
- pluripotent stem
- human pluripotent
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
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- C12N2533/74—Alginate
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/76—Agarose, agar-agar
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/78—Cellulose
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SG10201601965P | 2016-03-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201913687VA true SG10201913687VA (en) | 2020-03-30 |
Family
ID=59851957
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913687VA SG10201913687VA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
SG11201807487WA SG11201807487WA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201807487WA SG11201807487WA (en) | 2016-03-14 | 2017-03-14 | Generation of midbrain-specific organoids from human pluripotent stem cells |
Country Status (5)
Country | Link |
---|---|
US (1) | US20190169576A1 (en) |
EP (1) | EP3430132A4 (en) |
CN (1) | CN109996870A (en) |
SG (2) | SG10201913687VA (en) |
WO (1) | WO2017160234A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
ES2860423T3 (en) | 2014-05-28 | 2021-10-05 | Childrens Hospital Med Ct | Methods and Systems for Converting Stem Cells to Gastric Tissues by Targeted Differentiation |
CA2963704A1 (en) | 2014-10-17 | 2016-04-21 | Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US10583286B2 (en) * | 2016-08-23 | 2020-03-10 | Boston Scientific Neuromodulation Corporation | Methods and devices for neuromodulation of the adrenal gland |
AU2017373767B2 (en) | 2016-12-05 | 2021-09-16 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CN108456659B (en) * | 2018-03-14 | 2020-05-05 | 浙江霍德生物工程有限公司 | Preparation method of 3D brain organoid |
CN110295145B (en) * | 2018-03-22 | 2020-10-16 | 苏州麦迪耐斯医药科技有限公司 | Culture solution and culture method for in vitro culture of brain tumor cells |
US20220049219A1 (en) * | 2018-09-11 | 2022-02-17 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Automated generation and analysis of organoids |
WO2020100481A1 (en) * | 2018-11-15 | 2020-05-22 | Jsr株式会社 | Method for producing brain organoids |
US20220145247A1 (en) * | 2019-02-11 | 2022-05-12 | Miltenyi Biotec B.V. & Co. KG | Generation of human pluripotent stem cell derived artificial tissue structures without three dimensional matrices |
JP7366332B2 (en) * | 2019-06-05 | 2023-10-23 | 公立大学法人奈良県立医科大学 | Method for producing brainstem organoids |
CN114026222A (en) * | 2019-07-05 | 2022-02-08 | 学校法人庆应义塾 | Method for producing brain organoid |
KR102228400B1 (en) * | 2019-09-24 | 2021-03-16 | 고려대학교 산학협력단 | Method for preparing brain organoid |
WO2021099532A1 (en) * | 2019-11-22 | 2021-05-27 | Novo Nordisk A/S | Spin-aggregated neural microspheres and the application thereof |
MX2022008625A (en) * | 2020-01-13 | 2022-09-09 | Aspen Neuroscience Inc | Method of differentiating neural cells and related compositions and methods of use. |
WO2021216623A1 (en) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom |
WO2021216622A1 (en) * | 2020-04-21 | 2021-10-28 | Aspen Neuroscience, Inc. | Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom |
WO2021232234A1 (en) * | 2020-05-19 | 2021-11-25 | 武汉睿健医药科技有限公司 | Serum-free induction method for sensory neuron cell |
WO2021251820A1 (en) * | 2020-06-08 | 2021-12-16 | Technische Universiteit Eindhoven | Methods for producing a (three dimensional) neural tissue |
WO2022005023A1 (en) * | 2020-06-29 | 2022-01-06 | 주식회사 오간팩토리 | Midbrain organoid, method for rapidly producing same in large quantities, and method for screening neurotoxins and drug screening method for dopaminergic neuron-associated disease using same |
KR102346243B1 (en) * | 2020-06-29 | 2022-01-04 | 주식회사 오간팩토리 | Midbrain organoids, high-speed and large-scale manufacturing method thereof, neurotoxic screening methods, and drug screening methods for dopaminergic neuron-related diseases |
EP3992280A1 (en) * | 2020-10-30 | 2022-05-04 | Kugelmeiers Ltd. | Method for the generation of neurospheres |
CN114736864B (en) * | 2020-12-23 | 2024-01-26 | 武汉睿健医药科技有限公司 | Neural stem cell induced differentiation culture medium and induced differentiation method |
CN113046309B (en) * | 2021-03-26 | 2023-05-05 | 成都云测医学生物技术有限公司 | Culture medium for suspension culture of brain organoids and application thereof |
CN113249319B (en) * | 2021-05-19 | 2022-11-11 | 北京大学 | Culture medium and culture method for cerebrospinal fluid organoid |
CN113789301B (en) * | 2021-08-27 | 2022-05-10 | 广州瑞臻再生医学科技有限公司 | Method for preparing high-purity induced pluripotent stem cell-derived human brain dopaminergic neuron |
CN113493768B (en) * | 2021-09-06 | 2021-12-24 | 中国科学院动物研究所 | Neural organoids and methods of making the same |
KR20230081737A (en) * | 2021-11-29 | 2023-06-08 | 주식회사 오간팩토리 | Liver organoids, high-speed and large-scale manufacturing method thereof, and drug efficacy and toxicity screening methods using the same |
WO2023137200A2 (en) * | 2022-01-13 | 2023-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Generation of neural organizer organoids and midline assembloids from human pluripotent stem cells |
CN115404218A (en) * | 2022-01-13 | 2022-11-29 | 南华大学附属第一医院 | 3D human brain organoid culture method containing glial cells |
WO2023201046A1 (en) * | 2022-04-14 | 2023-10-19 | Lieber Institute, Inc. | Compositions and method for the treatment of x-linked dystonia parkinsonism |
EP4286513A1 (en) | 2022-06-03 | 2023-12-06 | IMBA-Institut für Molekulare Biotechnologie GmbH | Triple tissue culture fusion |
EP4310177A1 (en) * | 2022-07-19 | 2024-01-24 | Medizinische Hochschule Hannover | Process for producing organoids from mammalian cells |
WO2024017538A1 (en) * | 2022-07-19 | 2024-01-25 | Medizinische Hochschule Hannover | Process for producing organoids from mammalian cells |
CN115044539A (en) * | 2022-08-16 | 2022-09-13 | 中义(北京)健康研究院 | Shark liver cell and culture method thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
AU2013251749B2 (en) * | 2012-04-24 | 2019-01-17 | International Stem Cell Corporation | Derivation of neural stem cells and dopaminergic neurons from human pluripotent stem cells |
EP2743345A1 (en) * | 2012-12-13 | 2014-06-18 | IMBA-Institut für Molekulare Biotechnologie GmbH | Three dimensional heterogeneously differentiated tissue culture |
KR101696874B1 (en) * | 2013-07-31 | 2017-01-16 | 한국생명공학연구원 | A method for preparation of induced dopaminergic progenitors using direct reprogramming |
DE102014003465A1 (en) * | 2014-03-11 | 2015-09-17 | NeuroProof GmbH | Obtaining brain region-specific neuronal cultures from three-dimensional tissue cultures of stem cells |
US9694036B2 (en) * | 2014-03-21 | 2017-07-04 | Cellular Dynamics International, Inc. | Production of midbrain dopaminergic neurons and methods for the use thereof |
CN107427537A (en) * | 2015-03-03 | 2017-12-01 | 哈佛学院院长及董事 | The method for producing feature tissue |
LU92845B1 (en) * | 2015-10-08 | 2017-05-02 | Univ Du Luxembourg Campus Belval | Means and methods for generating midbrain organoids |
EP3190176A1 (en) * | 2016-01-11 | 2017-07-12 | IMBA-Institut für Molekulare Biotechnologie GmbH | Method for tissue culture development on scaffold and differentiated tissue culture |
-
2017
- 2017-03-14 SG SG10201913687VA patent/SG10201913687VA/en unknown
- 2017-03-14 WO PCT/SG2017/050126 patent/WO2017160234A1/en active Application Filing
- 2017-03-14 US US16/085,553 patent/US20190169576A1/en active Pending
- 2017-03-14 EP EP17767082.5A patent/EP3430132A4/en active Pending
- 2017-03-14 SG SG11201807487WA patent/SG11201807487WA/en unknown
- 2017-03-14 CN CN201780029142.2A patent/CN109996870A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CN109996870A (en) | 2019-07-09 |
SG11201807487WA (en) | 2018-09-27 |
EP3430132A4 (en) | 2019-12-25 |
WO2017160234A1 (en) | 2017-09-21 |
EP3430132A1 (en) | 2019-01-23 |
US20190169576A1 (en) | 2019-06-06 |
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