JP2017525354A5 - - Google Patents
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- JP2017525354A5 JP2017525354A5 JP2017505807A JP2017505807A JP2017525354A5 JP 2017525354 A5 JP2017525354 A5 JP 2017525354A5 JP 2017505807 A JP2017505807 A JP 2017505807A JP 2017505807 A JP2017505807 A JP 2017505807A JP 2017525354 A5 JP2017525354 A5 JP 2017525354A5
- Authority
- JP
- Japan
- Prior art keywords
- cell death
- high affinity
- programmed cell
- polypeptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100040678 Programmed cell death protein 1 Human genes 0.000 claims 63
- 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 63
- 229920001184 polypeptide Polymers 0.000 claims 29
- 102000004196 processed proteins & peptides Human genes 0.000 claims 29
- 108090000765 processed proteins & peptides Proteins 0.000 claims 29
- 102220496972 Platelet-activating factor acetylhydrolase 2, cytoplasmic_K53T_mutation Human genes 0.000 claims 18
- 102220058921 rs786202731 Human genes 0.000 claims 18
- 102200118229 rs34665886 Human genes 0.000 claims 17
- 102220161672 rs148219510 Human genes 0.000 claims 13
- 102220586093 Homeobox protein DLX-1_V39R_mutation Human genes 0.000 claims 10
- 102220354149 c.289C>A Human genes 0.000 claims 10
- 102220568823 Dual specificity mitogen-activated protein kinase kinase 1_G65V_mutation Human genes 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 102220249043 rs145159429 Human genes 0.000 claims 9
- 102220226094 rs17217723 Human genes 0.000 claims 9
- 102220311149 rs41271047 Human genes 0.000 claims 9
- 102220279022 rs955258267 Human genes 0.000 claims 9
- 102220507725 GTP-binding protein RAD_Q66P_mutation Human genes 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 7
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 7
- 102220585589 Short-chain dehydrogenase/reductase family 42E member 1_Q63P_mutation Human genes 0.000 claims 7
- 102220361097 c.307C>T Human genes 0.000 claims 5
- 230000003278 mimic effect Effects 0.000 claims 5
- 102220013742 rs397516741 Human genes 0.000 claims 5
- 102220257864 rs1050971384 Human genes 0.000 claims 4
- 102220198136 rs1057519882 Human genes 0.000 claims 4
- 102200116701 rs115206969 Human genes 0.000 claims 4
- 102220250913 rs1364636517 Human genes 0.000 claims 4
- 102220624338 Interferon alpha-8_T51A_mutation Human genes 0.000 claims 3
- 102220492589 Protein numb homolog_S48D_mutation Human genes 0.000 claims 3
- 102220477170 Y-box-binding protein 2_S102A_mutation Human genes 0.000 claims 3
- 102220364119 c.148C>A Human genes 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 102200007406 rs148775298 Human genes 0.000 claims 3
- 102200017902 rs267606847 Human genes 0.000 claims 3
- 102220252689 rs373178770 Human genes 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102220492635 Integrin alpha-3_D52Y_mutation Human genes 0.000 claims 2
- 102100040418 Tumor protein D52 Human genes 0.000 claims 2
- 102220555263 Tumor protein D52_D52Y_mutation Human genes 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102220487428 Actin-related protein 2/3 complex subunit 3_R90K_mutation Human genes 0.000 claims 1
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 claims 1
- 229940123189 CD40 agonist Drugs 0.000 claims 1
- 108010062802 CD66 antigens Proteins 0.000 claims 1
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims 1
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 claims 1
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 claims 1
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000037581 Persistent Infection Diseases 0.000 claims 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 claims 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 102220349284 c.287A>T Human genes 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002600 positron emission tomography Methods 0.000 claims 1
- 102200160087 rs1131692231 Human genes 0.000 claims 1
- 102220126393 rs886044243 Human genes 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035316P | 2014-08-08 | 2014-08-08 | |
| US62/035,316 | 2014-08-08 | ||
| US201562150789P | 2015-04-21 | 2015-04-21 | |
| US62/150,789 | 2015-04-21 | ||
| PCT/US2015/044356 WO2016022994A2 (en) | 2014-08-08 | 2015-08-07 | High affinity pd-1 agents and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017525354A JP2017525354A (ja) | 2017-09-07 |
| JP2017525354A5 true JP2017525354A5 (https=) | 2018-09-13 |
| JP6945444B2 JP6945444B2 (ja) | 2021-10-06 |
Family
ID=55264785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017505807A Active JP6945444B2 (ja) | 2014-08-08 | 2015-08-07 | 高親和性ｐｄ−１薬剤とその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9546206B2 (https=) |
| EP (2) | EP3177640B1 (https=) |
| JP (1) | JP6945444B2 (https=) |
| CN (1) | CN107108707A (https=) |
| CA (1) | CA2994927A1 (https=) |
| CY (1) | CY1123385T1 (https=) |
| DK (1) | DK3177640T3 (https=) |
| ES (1) | ES2819451T3 (https=) |
| HR (1) | HRP20201153T1 (https=) |
| HU (1) | HUE050406T2 (https=) |
| PL (1) | PL3177640T3 (https=) |
| PT (1) | PT3177640T (https=) |
| WO (1) | WO2016022994A2 (https=) |
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| EP2934532B1 (en) | 2012-12-20 | 2019-10-23 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| US9546206B2 (en) | 2014-08-08 | 2017-01-17 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity PD-1 agents and methods of use |
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| ES2981335T3 (es) | 2014-11-25 | 2024-10-08 | Bristol Myers Squibb Co | Novedosos polipéptidos de unión a PD-L1 para obtención de imágenes |
| MX385081B (es) | 2014-11-25 | 2025-03-14 | Bristol Myers Squibb Co | Métodos y composiciones para radioetiquetado con 18f de productos biológicos. |
| KR102133857B1 (ko) * | 2015-03-02 | 2020-07-20 | 이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 | Ｐｄ－ｌ１에 의해 유도된 면역관용의 감소 |
| MY188430A (en) * | 2015-04-10 | 2021-12-08 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
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