JP2017524715A5 - - Google Patents
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- JP2017524715A5 JP2017524715A5 JP2017507739A JP2017507739A JP2017524715A5 JP 2017524715 A5 JP2017524715 A5 JP 2017524715A5 JP 2017507739 A JP2017507739 A JP 2017507739A JP 2017507739 A JP2017507739 A JP 2017507739A JP 2017524715 A5 JP2017524715 A5 JP 2017524715A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- binding portion
- specifically binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1414270.7 | 2014-08-12 | ||
| GBGB1414270.7A GB201414270D0 (en) | 2014-08-12 | 2014-08-12 | Antibodies |
| GB1422614.6 | 2014-12-18 | ||
| GB201422614 | 2014-12-18 | ||
| GBGB1507541.9A GB201507541D0 (en) | 2015-05-01 | 2015-05-01 | Antibodies |
| GB1507541.9 | 2015-05-01 | ||
| PCT/EP2015/068598 WO2016023960A1 (en) | 2014-08-12 | 2015-08-12 | Combination therapies with anti cd40 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017524715A JP2017524715A (ja) | 2017-08-31 |
| JP2017524715A5 true JP2017524715A5 (https=) | 2018-09-27 |
| JP6654187B2 JP6654187B2 (ja) | 2020-02-26 |
Family
ID=53836090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017507739A Active JP6654187B2 (ja) | 2014-08-12 | 2015-08-12 | 抗cd40抗体を用いた併用療法 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US11149090B2 (https=) |
| EP (3) | EP3180087B1 (https=) |
| JP (1) | JP6654187B2 (https=) |
| KR (1) | KR102443258B1 (https=) |
| CN (3) | CN119280407A (https=) |
| AU (1) | AU2015303164B2 (https=) |
| CA (1) | CA2957146A1 (https=) |
| CL (1) | CL2017000335A1 (https=) |
| CO (1) | CO2017001317A2 (https=) |
| CR (1) | CR20170096A (https=) |
| DK (1) | DK3180087T3 (https=) |
| EA (1) | EA201790339A1 (https=) |
| EC (1) | ECSP17008984A (https=) |
| ES (1) | ES2725463T3 (https=) |
| IL (1) | IL250512B (https=) |
| MA (1) | MA47472A (https=) |
| MX (1) | MX382549B (https=) |
| NI (1) | NI201700015A (https=) |
| PE (1) | PE20170680A1 (https=) |
| PH (1) | PH12017500229A1 (https=) |
| SG (1) | SG11201701070WA (https=) |
| SV (1) | SV2017005380A (https=) |
| UA (1) | UA119783C2 (https=) |
| WO (1) | WO2016023960A1 (https=) |
| ZA (1) | ZA201701126B (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2709654T3 (es) | 2011-04-29 | 2019-04-17 | Apexigen Inc | Anticuerpos anti-CD40 y métodos de uso |
| KR102270618B1 (ko) | 2012-10-30 | 2021-06-30 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
| EP3936137A1 (en) | 2013-02-07 | 2022-01-12 | The General Hospital Corporation | Methods for expansion or depletion of t-regulatory cells |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| CN115043943A (zh) | 2015-05-15 | 2022-09-13 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
| US20190135929A1 (en) | 2015-08-28 | 2019-05-09 | The General Hospital Corporation | Agonistic anti-tumor necrosis factor receptor 2 antibodies |
| IL300122A (en) | 2015-11-18 | 2023-03-01 | Merck Sharp ַ& Dohme Llc | Substances that bind to PD1 and/or LAG3 |
| IL260021B (en) | 2015-12-14 | 2022-09-01 | Macrogenics Inc | Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them |
| US11859002B2 (en) * | 2016-05-13 | 2024-01-02 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor 2 antibodies |
| RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
| WO2018011421A1 (en) * | 2016-07-14 | 2018-01-18 | Genmab A/S | Multispecific antibodies against cd40 and cd137 |
| CN109790220A (zh) | 2016-08-25 | 2019-05-21 | 豪夫迈·罗氏有限公司 | 与巨噬细胞激活剂组合的抗csf-1r抗体的间歇给药 |
| EP3532505A4 (en) | 2016-10-25 | 2019-12-25 | Urogen Pharma Ltd. | BODY CAVES IMMUNODULATING TREATMENTS |
| CN110114089A (zh) * | 2016-11-02 | 2019-08-09 | 埃派斯进有限公司 | 组合中的抗cd40抗体及其使用方法 |
| CN110072553B (zh) | 2016-12-22 | 2023-09-15 | 豪夫迈·罗氏有限公司 | 在抗pd-l1/pd1治疗失败之后抗csf-1r抗体与抗pd-l1抗体组合对肿瘤的治疗 |
| EP3569616B1 (en) * | 2017-01-13 | 2021-09-29 | Taizhou Hanzhong Biopharmaceutics, Inc. | Monoclonal antibody against pd-1 and applications thereof |
| WO2018160917A1 (en) * | 2017-03-03 | 2018-09-07 | Janssen Biotech, Inc. | Co-therapy comprising a small molecule csf-1r inhibitor and an agonistic antibody that specifically binds cd40 for the treatment of cancer |
| SG11202000198QA (en) | 2017-08-04 | 2020-02-27 | Genmab As | Binding agents binding to pd-l1 and cd137 and use thereof |
| US12053505B2 (en) | 2017-08-31 | 2024-08-06 | Multimmune Gmbh | Hsp70 based combination therapy |
| MX2020009510A (es) * | 2018-03-13 | 2021-08-05 | Hibercell Inc | Inmunoterapia combinada de beta glucano y agonista cd40. |
| EP3807320A4 (en) * | 2018-06-12 | 2022-03-23 | BioNTech US Inc. | POLYTHERAPY INCLUDING A VACCINE BASED ON NEO ANTIGENS |
| KR20210035805A (ko) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가 |
| CN112912395B (zh) * | 2018-08-20 | 2024-08-23 | 辉瑞公司 | 抗gdf15抗体、组合物和使用方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN113302205B (zh) | 2018-11-15 | 2024-12-06 | 综合医院公司 | 激动性肿瘤坏死因子受体超家族多肽 |
| ES3016535T3 (en) | 2018-11-23 | 2025-05-09 | Strike Pharma Ab | Bi-specific conjugates |
| BR112021009835A2 (pt) * | 2018-11-30 | 2021-08-17 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo anti-cd40, fragmento de ligação ao antígeno e uso farmacêutico dos mesmos |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| AU2020284706A1 (en) * | 2019-05-28 | 2021-12-16 | Alligator Bioscience Ab | Method of providing safe administration of an anti-CD40 antibody |
| EP4027998A1 (en) | 2019-09-09 | 2022-07-20 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
| US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| US20230055235A1 (en) * | 2019-12-27 | 2023-02-23 | Interoligo Corporation. | Anti-cancer immunotherapeutic composition for treating cancer |
| GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| CN113861292A (zh) * | 2020-06-30 | 2021-12-31 | 百奥泰生物制药股份有限公司 | 抗cd40抗体或抗原结合片段及其应用 |
| WO2022036495A1 (en) | 2020-08-17 | 2022-02-24 | Utc Therapeutics Inc. | Lymphocytes-antigen presenting cells co-stimulators and uses thereof |
| EP4313109A1 (en) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
| AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| EP4415757A4 (en) * | 2021-10-15 | 2025-10-08 | Univ Rockefeller | COMBINATION OF ANTI-CD40 ANTIBODIES AND IL-15 FOR THE TREATMENT OF CANCER |
| WO2023076768A1 (en) * | 2021-10-26 | 2023-05-04 | Navicure Biopharmaceuticals Limited | Combination therapies against cancer and infectious diseases |
| WO2023247050A1 (en) | 2022-06-23 | 2023-12-28 | Alligator Bioscience Ab | Combination therapies |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| AU3374795A (en) | 1994-08-29 | 1996-03-22 | Prizm Pharmaceuticals, Inc. | Conjugates of vascular endothelial growth factor with targeted agents |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
| AU2001259215A1 (en) | 2000-04-28 | 2001-11-12 | La Jolla Institute For Allergy And Immunology | Human anti-cd40 antibodies and methods of making and using same |
| EP1341909B2 (en) | 2000-12-12 | 2012-04-11 | Alligator Bioscience AB | A method for in vitro molecular evolution of protein function |
| CA2658221C (en) | 2001-04-27 | 2012-11-27 | Kyowa Kirin Co., Ltd. | Anti-cd40 monoclonal antibody |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
| US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
| AU2003217912A1 (en) | 2002-03-01 | 2003-09-16 | Xencor | Antibody optimization |
| DK1504098T4 (da) | 2002-05-17 | 2011-05-23 | Alligator Bioscience Ab | Fremgangsmåde til molekyulær udvikling in vitro af proteinfunktion |
| CN101001872A (zh) * | 2004-04-16 | 2007-07-18 | 宏观基因有限公司 | FcγRIIB-特异性抗体及其使用方法 |
| WO2006073443A2 (en) | 2004-04-27 | 2006-07-13 | Novartis Vaccines And Diagnostics, Inc. | Antagonist anti-cd40 monoclonal antibodies and methods for their use |
| DK2439273T3 (da) | 2005-05-09 | 2019-06-03 | Ono Pharmaceutical Co | Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika |
| US8303955B2 (en) | 2005-05-26 | 2012-11-06 | Seattle Genetics, Inc. | Humanized anti-CD40 antibodies and their methods of use |
| GB0620894D0 (en) * | 2006-10-20 | 2006-11-29 | Univ Southampton | Human immune therapies using a CD27 agonist alone or in combination with other immune modulators |
| CA2712989C (en) | 2008-01-23 | 2015-10-27 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
| CA2735421A1 (en) * | 2008-08-29 | 2010-03-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Delivery of a cd40 agonist to a tumor draining lymph node of a subject |
| CN102695772B (zh) * | 2009-09-16 | 2015-09-16 | 纳幕尔杜邦公司 | 装有反式-1,1,1,4,4,4-六氟-2-丁烯的冷却器设备以及在其中制冷的方法 |
| GB201006096D0 (en) | 2010-04-13 | 2010-05-26 | Alligator Bioscience Ab | Novel compositions and uses thereof |
| MX368257B (es) | 2011-08-01 | 2019-09-26 | Genentech Inc | Antagonistas de unión al eje pd-1e inhibidores de mek y sus usos en el tratamiento de cáncer. |
| GB201115280D0 (en) * | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
| WO2014121099A1 (en) * | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Agonist fusion protein for cd40 ox40 and uses thereof |
| CN105611944A (zh) | 2013-12-20 | 2016-05-25 | 豪夫迈·罗氏有限公司 | 抗ang2抗体和cd40激动剂的组合疗法 |
| TWI693232B (zh) | 2014-06-26 | 2020-05-11 | 美商宏觀基因股份有限公司 | 與pd-1和lag-3具有免疫反應性的共價結合的雙抗體和其使用方法 |
| US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
| KR20250004095A (ko) | 2015-04-17 | 2025-01-07 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물 |
| CN107810198B (zh) | 2015-05-29 | 2021-09-03 | 艾伯维公司 | 抗cd40抗体及其用途 |
| BR112017027549A2 (pt) | 2015-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | anticorpo para cd40 |
| CN107922500A (zh) | 2015-06-29 | 2018-04-17 | 洛克菲勒大学 | 具有增强的激动剂活性的抗cd40抗体 |
-
2015
- 2015-08-12 CA CA2957146A patent/CA2957146A1/en active Pending
- 2015-08-12 CR CR20170096A patent/CR20170096A/es unknown
- 2015-08-12 ES ES15750051T patent/ES2725463T3/es active Active
- 2015-08-12 UA UAA201701452A patent/UA119783C2/uk unknown
- 2015-08-12 CN CN202411444693.3A patent/CN119280407A/zh active Pending
- 2015-08-12 JP JP2017507739A patent/JP6654187B2/ja active Active
- 2015-08-12 CN CN202111420044.6A patent/CN114099671A/zh active Pending
- 2015-08-12 EP EP15750051.3A patent/EP3180087B1/en active Active
- 2015-08-12 US US15/329,402 patent/US11149090B2/en active Active
- 2015-08-12 KR KR1020177005821A patent/KR102443258B1/ko active Active
- 2015-08-12 EP EP19161728.1A patent/EP3552665A3/en not_active Withdrawn
- 2015-08-12 AU AU2015303164A patent/AU2015303164B2/en active Active
- 2015-08-12 PE PE2017000203A patent/PE20170680A1/es unknown
- 2015-08-12 CN CN201580043161.1A patent/CN106573981A/zh active Pending
- 2015-08-12 MA MA047472A patent/MA47472A/fr unknown
- 2015-08-12 WO PCT/EP2015/068598 patent/WO2016023960A1/en not_active Ceased
- 2015-08-12 SG SG11201701070WA patent/SG11201701070WA/en unknown
- 2015-08-12 DK DK15750051.3T patent/DK3180087T3/da active
- 2015-08-12 EP EP25194883.2A patent/EP4653463A3/en active Pending
- 2015-08-12 MX MX2017001864A patent/MX382549B/es unknown
- 2015-08-12 EA EA201790339A patent/EA201790339A1/ru unknown
-
2017
- 2017-02-07 PH PH12017500229A patent/PH12017500229A1/en unknown
- 2017-02-07 SV SV2017005380A patent/SV2017005380A/es unknown
- 2017-02-08 IL IL250512A patent/IL250512B/en unknown
- 2017-02-09 NI NI201700015A patent/NI201700015A/es unknown
- 2017-02-09 CL CL2017000335A patent/CL2017000335A1/es unknown
- 2017-02-10 EC ECIEPI20178984A patent/ECSP17008984A/es unknown
- 2017-02-10 CO CONC2017/0001317A patent/CO2017001317A2/es unknown
- 2017-02-15 ZA ZA2017/01126A patent/ZA201701126B/en unknown
-
2021
- 2021-09-15 US US17/475,592 patent/US20210403589A1/en not_active Abandoned
-
2023
- 2023-12-13 US US18/538,429 patent/US12570753B2/en active Active
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