JP2017522113A5 - - Google Patents

Download PDF

Info

Publication number
JP2017522113A5
JP2017522113A5 JP2017502712A JP2017502712A JP2017522113A5 JP 2017522113 A5 JP2017522113 A5 JP 2017522113A5 JP 2017502712 A JP2017502712 A JP 2017502712A JP 2017502712 A JP2017502712 A JP 2017502712A JP 2017522113 A5 JP2017522113 A5 JP 2017522113A5
Authority
JP
Japan
Prior art keywords
microgel particles
gel system
microporous gel
annealing
microporous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017502712A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017522113A (ja
JP6651500B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/040962 external-priority patent/WO2016011387A1/en
Publication of JP2017522113A publication Critical patent/JP2017522113A/ja
Publication of JP2017522113A5 publication Critical patent/JP2017522113A5/ja
Application granted granted Critical
Publication of JP6651500B2 publication Critical patent/JP6651500B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017502712A 2014-07-17 2015-07-17 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子 Active JP6651500B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462025844P 2014-07-17 2014-07-17
US62/025,844 2014-07-17
US201462059463P 2014-10-03 2014-10-03
US62/059,463 2014-10-03
US201562103002P 2015-01-13 2015-01-13
US62/103,002 2015-01-13
PCT/US2015/040962 WO2016011387A1 (en) 2014-07-17 2015-07-17 Controllable self-annealing microgel particles for biomedical applications

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020008247A Division JP7188779B2 (ja) 2014-07-17 2020-01-22 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子

Publications (3)

Publication Number Publication Date
JP2017522113A JP2017522113A (ja) 2017-08-10
JP2017522113A5 true JP2017522113A5 (https=) 2018-08-30
JP6651500B2 JP6651500B2 (ja) 2020-02-19

Family

ID=55079098

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017502712A Active JP6651500B2 (ja) 2014-07-17 2015-07-17 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子
JP2020008247A Active JP7188779B2 (ja) 2014-07-17 2020-01-22 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子
JP2022134723A Active JP7627498B2 (ja) 2014-07-17 2022-08-26 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020008247A Active JP7188779B2 (ja) 2014-07-17 2020-01-22 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子
JP2022134723A Active JP7627498B2 (ja) 2014-07-17 2022-08-26 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子

Country Status (11)

Country Link
US (7) US20160279283A1 (https=)
EP (1) EP3169372B1 (https=)
JP (3) JP6651500B2 (https=)
KR (4) KR102264607B1 (https=)
CN (2) CN111939316B (https=)
AU (1) AU2015289474B2 (https=)
BR (1) BR112017000813B1 (https=)
CA (1) CA2955357A1 (https=)
ES (1) ES3002759T3 (https=)
IL (2) IL282559B (https=)
WO (1) WO2016011387A1 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009134354A1 (en) 2008-04-30 2009-11-05 Flanigan Theodore P System and method for pre-treatment of rubber-modified asphalt cement, and emulsions thereof
EP2346940A4 (en) 2008-09-24 2013-04-24 Wright Advanced Asphalt Systems SYSTEM AND METHOD FOR THE PRODUCTION OF RUBBER-MODIFIED ASPHALT CEMENT HIGH-PERFORMANCE
KR102264607B1 (ko) 2014-07-17 2021-06-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자
GB201514788D0 (en) 2015-08-20 2015-10-07 Ecole Polytech Malleable scaffold material and uses thereof
WO2017136427A1 (en) * 2016-02-02 2017-08-10 The Regents Of The University Of California Hydrogel for endogenous neuroprogenitor cell recruitment
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
ES2989467T3 (es) 2016-04-08 2024-11-26 Univ California Hidrogel para la respuesta inmune diseñada a péptidos con D-quiralidad
WO2018013726A1 (en) * 2016-07-12 2018-01-18 Northeastern University Single cell fluorescence in situ hybridization in microfluidic droplets
JP6345736B2 (ja) * 2016-07-15 2018-06-20 国立研究開発法人科学技術振興機構 液滴安定化装置、液滴分取装置及びそれらの方法
CN110446508A (zh) * 2016-12-29 2019-11-12 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
WO2018144481A1 (en) 2017-01-31 2018-08-09 The Regents Of The University Of California Multi-arm block-copolymers for multifunctional self-assembled systems
WO2018156935A1 (en) 2017-02-24 2018-08-30 The Regents Of The University Of California Particle-drop structures and methods for making and using the same
US11131673B2 (en) 2017-04-27 2021-09-28 Northeastern University Live single-cell bioassay in microdroplets
US11129790B2 (en) 2017-05-19 2021-09-28 Northeastern University Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
US11926091B2 (en) 2018-03-27 2024-03-12 UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
CA3097047A1 (en) 2018-04-13 2019-10-17 University Of Virginia Patent Foundation Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices
EP3866867A4 (en) * 2018-10-18 2022-07-13 The Regents of the University of California PROCESS FOR THE PREPARATION OF MODULAR HYDROGELS FROM MACROMOLECULES WITH ORTHOGONAL PHYSICOCHEMICAL REACTION
ES2969884T3 (es) 2019-04-02 2024-05-23 Volumina Medical Sa Composición que comprende un poliol reticulado
EP3789049A1 (en) * 2019-09-06 2021-03-10 QGel SA Method for obtaining healthy intestinal organoids
US20230001055A1 (en) * 2019-12-06 2023-01-05 University Of Virginia Patent Foundation Injectable micro-annealed porous scaffold for articular cartilage regeneration
WO2021174008A1 (en) * 2020-02-28 2021-09-02 University Of Florida Research Foundation Compositions, methods, kits, and systems relating to charge-neutral microgels for 3d cell culture and printing
JP2021171180A (ja) * 2020-04-21 2021-11-01 株式会社ユニバーサルエンターテインメント 遊技機
WO2022016013A1 (en) * 2020-07-16 2022-01-20 The Regents Of The University Of California Injectable drug-releasing microporous annealed particle scaffolds for treating myocardial infarction
US12280540B2 (en) 2020-09-27 2025-04-22 San Diego State University Research Foundation In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
US11879118B2 (en) * 2020-11-10 2024-01-23 C.C. Imex Gel tray for bacteria transformation lab
CA3215070A1 (en) 2021-04-14 2022-10-20 Joseph DE RUTTE Nanoscale reaction chambers and methods of using the same
CA3220391A1 (en) * 2021-05-27 2022-12-01 Charles Blaha Superporous gel matrix for encapsulation of cells
EP4373899A4 (en) * 2021-07-21 2026-01-14 Harvard College METHODS FOR CROSS-CROSSING POLYMERS AND HYDROGEL MICROPARTICLES AND FOR ENCAPSULATING BIOLOGICALLY ACTIVE COMPOUNDS, COMPOSITIONS PRODUCED FROM THESE AND DEVICES
KR20230059380A (ko) * 2021-10-26 2023-05-03 강원대학교산학협력단 피부 복원용 3차원 스캐폴드
US20250205392A1 (en) * 2022-03-29 2025-06-26 The Penn State Research Foundation Device and method for accelerating and guiding vascularization
WO2024015656A1 (en) * 2022-07-11 2024-01-18 The Regents Of The University Of California Cell-microgel encapsulation in injectable formulations
US20240026088A1 (en) 2022-07-19 2024-01-25 CellDrop Biosciences, Inc. Hydrogel Particle Encapsulation and Suspension Media Removal
US20260051184A1 (en) * 2022-08-04 2026-02-19 Duke University Systems and methods for analysis of microporous annealed particle scaffolds
WO2024036108A1 (en) * 2022-08-09 2024-02-15 Bionaut Labs Ltd. Devices, systems, and methods for the treatment of malignant neoplasm disorders using controlled release devices
CN116077736A (zh) * 2022-09-26 2023-05-09 四川大学 基于多孔明胶复合微球的可注射骨修复支架及其制备方法
WO2025054490A1 (en) * 2023-09-08 2025-03-13 Rasyn, Llc Multi-omic analysis using beyond-poisson droplet loading
CN117462751A (zh) * 2023-10-30 2024-01-30 南京鼓楼医院 一种甲基丙烯酰化明胶微孔退火颗粒支架及其制备方法
WO2025096900A1 (en) * 2023-11-03 2025-05-08 Board Of Regents, The University Of Texas System Synthetic network materials and methods of making and use thereof
WO2025247844A1 (en) 2024-05-28 2025-12-04 Eth Zurich Granular hydrogel combinations for wound healing

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4726877A (en) * 1986-01-22 1988-02-23 E. I. Du Pont De Nemours And Company Methods of using photosensitive compositions containing microgels
US4753865A (en) 1986-01-22 1988-06-28 E. I. Du Pont De Nemours And Company Photosensitive compositions containing microgels
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5124188A (en) 1990-04-02 1992-06-23 The Procter & Gamble Company Porous, absorbent, polymeric macrostructures and methods of making the same
KR100266912B1 (ko) 1992-02-28 2000-12-01 파라비 레이 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔
JP3156955B2 (ja) * 1995-07-12 2001-04-16 大日精化工業株式会社 連結されたミクロゲル粒子の製造方法及びそれで処理された物品
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
US6007833A (en) 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
US7547445B2 (en) 1998-03-19 2009-06-16 Surmodics, Inc. Crosslinkable macromers
US6410044B1 (en) 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
KR100683603B1 (ko) 1998-10-23 2007-02-20 폴리힐 엘티디. 창상 치유용 미소구 조성물
US7615373B2 (en) * 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
AU7084300A (en) 1999-08-27 2001-03-26 Cohesion Technologies, Inc. Compositions that form interpenetrating polymer networks for use as high strength medical sealants
JP4485124B2 (ja) 2000-11-17 2010-06-16 ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション 電気処理されたコラーゲン
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
US6669827B2 (en) 2001-06-18 2003-12-30 Austin & Neff, L.L.C. Systems and methods for affecting the ultra-fast photodissociation of water molecules
GB0115320D0 (en) 2001-06-22 2001-08-15 Univ Nottingham Matrix
US20040258731A1 (en) 2001-11-21 2004-12-23 Tsuyoshi Shimoboji Preparation approriate for cartilage tissue formation
US7745532B2 (en) 2002-08-02 2010-06-29 Cambridge Polymer Group, Inc. Systems and methods for controlling and forming polymer gels
US20040147016A1 (en) 2002-09-30 2004-07-29 Rowley Jonathan A. Programmable scaffold and methods for making and using the same
US8574204B2 (en) 2002-10-21 2013-11-05 Angiodynamics, Inc. Implantable medical device for improved placement and adherence in the body
CA2517204A1 (en) * 2003-03-13 2004-09-23 Eugenia Kumacheva Method of producing hybrid polymer-inorganic materials
EP1652019A2 (en) 2003-06-30 2006-05-03 Nupower Semiconductor, Inc. Programmable calibration circuit for power supply current sensing and droop loss compensation
WO2005032418A2 (en) 2003-10-01 2005-04-14 University Of Washington Novel porous biomaterials
ATE524203T1 (de) 2003-11-03 2011-09-15 Medtronic Inc Hydrogel für zellspezifisches einwachsen
AU2005318097A1 (en) * 2004-12-22 2006-06-29 Kuros Biosurgery Ag Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors
WO2007044669A2 (en) 2005-10-07 2007-04-19 Lonza Walkersville, Inc. Engineered biological matrices
GB2431104A (en) 2005-10-10 2007-04-18 Univ Greenwich Microgel particles grafted to a substrate
US9132208B2 (en) * 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
US8029575B2 (en) 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
PT2347775T (pt) * 2005-12-13 2020-07-14 The President And Fellows Of Harvard College Estruturas em andaime para transplante celular
EP1808187A1 (en) * 2006-01-11 2007-07-18 Straumann Holding AG Cell selective implant surface with controlled release of bioactive agents
CN101410098B (zh) 2006-01-23 2012-01-18 耶路撒冷希伯来大学伊森姆研究发展公司 包括含亲脂性药物的纳米胶囊的微球
US20070212385A1 (en) 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
US20080193536A1 (en) * 2006-08-14 2008-08-14 Alireza Khademhosseini Cell-Laden Hydrogels
DE102006040772A1 (de) 2006-08-31 2008-03-20 Kist-Europe Forschungsgesellschaft Mbh Polymermatrix, Verfahren zu deren Herstellung sowie deren Verwendung
GB0701896D0 (en) * 2007-02-01 2007-03-14 Regentec Ltd Composition
US8277832B2 (en) * 2007-10-10 2012-10-02 The University Of Kansas Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals
US20090294049A1 (en) 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Biodegradable Adhesive Hydrogels
JP2012501965A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
US8557288B2 (en) 2008-08-15 2013-10-15 Washington University Hydrogel microparticle formation in aqueous solvent for biomedical applications
US20120015440A1 (en) 2008-09-08 2012-01-19 Tokyo University Of Science Educational Foundation Administrative Org. Spheroid composite, spheroid-containing hydrogel and processes for production of same
US11090387B2 (en) 2008-12-22 2021-08-17 The Trustees Of The University Of Pennsylvania Hydrolytically degradable polysaccharide hydrogels
CN102573913B (zh) 2009-07-31 2014-06-18 阿森迪斯药物股份有限公司 可生物降解的基于聚乙二醇的水不溶性水凝胶
AU2010325158B2 (en) 2009-11-25 2014-09-04 Healionics Corporation Granules of porous biocompatible materials
GB201002862D0 (en) 2010-02-19 2010-04-07 Univ Manchester Microgel compositions
WO2011127395A1 (en) 2010-04-08 2011-10-13 Healionics Corporation Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same
US20110256628A1 (en) 2010-04-20 2011-10-20 The University Of Washington Through Its Center For Commercialization Adaptive tissue engineering scaffold
US8524215B2 (en) 2010-08-02 2013-09-03 Janssen Biotech, Inc. Absorbable PEG-based hydrogels
JP6104806B2 (ja) * 2010-10-06 2017-03-29 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 材料に基づく細胞治療のための注射可能孔形成性ハイドロゲル
EP2641094B1 (en) 2010-11-18 2019-03-06 The Regents of The University of California Method for high-throughput solution exchange for cell and particle suspensions
WO2012068003A2 (en) 2010-11-18 2012-05-24 The Regents Of The University Of California Particle focusing systems and methods
US9234171B2 (en) 2010-12-08 2016-01-12 Rutgers, The State University Of New Jersey Stem cell differentiation using novel light-responsive hydrogels
US20120202263A1 (en) 2011-02-03 2012-08-09 The Trustees Of The University Of Pennsylvania Bioactive Macromers and Hydrogels and Methods for Producing Same
US10260039B2 (en) * 2011-05-11 2019-04-16 Massachusetts Institute Of Technology Microgels and microtissues for use in tissue engineering
WO2012170706A2 (en) 2011-06-08 2012-12-13 Surmodics, Inc. Photo-vinyl linking agents
WO2013033717A1 (en) 2011-09-02 2013-03-07 The Regents Of The University Of California Enzyme responsive nanocapsules for protein delivery
JP6075735B2 (ja) 2011-09-30 2017-02-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 配列された微小構造を用いて流体流れをプログラムするデバイスおよび方法
US20150104427A1 (en) 2011-11-10 2015-04-16 The Regents Of The University Of California Enzyme-assisted spatial decoration of biomaterials
KR101820792B1 (ko) * 2011-12-20 2018-01-23 한온시스템 주식회사 차량 공조장치용 컨트롤러
US9974886B2 (en) * 2012-08-08 2018-05-22 Nanyang Technological University Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering
US10201613B2 (en) 2012-09-07 2019-02-12 The Regents Of The University Of California Method of creating hydrogels through oxime bond formation
US9364543B2 (en) 2012-10-24 2016-06-14 Indiana University Research And Technology Corporation Visible light curable hydrogels and methods for using
EP2801613A1 (en) 2013-05-08 2014-11-12 Ecole Polytechnique Fédérale de Lausanne (EPFL) Arrays of discrete cell culture microenvironments, methods of making such arrays and uses thereof
US9381217B2 (en) 2013-09-09 2016-07-05 Georgia Tech Research Corporation Microgels for encapsulation of cells and other biologic agents
US20150290362A1 (en) 2014-04-10 2015-10-15 Georgia Tech Research Corporation Hybrid fibrin-microgel constructs for tissue repair and regeneration
KR102264607B1 (ko) * 2014-07-17 2021-06-14 더 리전트 오브 더 유니버시티 오브 캘리포니아 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자
WO2016096054A1 (en) 2014-12-19 2016-06-23 Ecole Polytechnique Federale De Lausanne (Epfl) Method and device for mixing two streams of droplets
US20160303281A1 (en) 2015-04-17 2016-10-20 Rochal Industries, Llc Composition and kits for pseudoplastic microgel matrices
US20200305773A1 (en) 2016-01-21 2020-10-01 The Regents Of The University Of California Device and method for analyte sensing with microporous annealed particle gels
WO2017136427A1 (en) 2016-02-02 2017-08-10 The Regents Of The University Of California Hydrogel for endogenous neuroprogenitor cell recruitment
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
CN110446508A (zh) 2016-12-29 2019-11-12 泰普治疗公司 用于治疗医疗植入物部位的方法和系统

Similar Documents

Publication Publication Date Title
JP2017522113A5 (https=)
JP7627498B2 (ja) 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子
Xiao et al. A viscous‐biofluid self‐pumping organohydrogel dressing to accelerate diabetic wound healing
Yu et al. Asymmetric wettable composite wound dressing prepared by electrospinning with bioinspired micropatterning enhances diabetic wound healing
Hölzl et al. Bioink properties before, during and after 3D bioprinting
Tang et al. Molding of three-dimensional microstructures of gels
RU2015129771A (ru) Микроматрица для доставки терапевтического средства и способы использования
PE20100057A1 (es) Sistema de suministro intrauterino para la liberacion controlada de progestageno
Repanas et al. Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system
JP6810052B2 (ja) フィブリン組成物、方法及び創傷物品
AU2010201192A1 (en) Microneedle array using porous substrate and production method thereof
CN107109167A (zh) 丙烯酸类粘合片，医用粘合带，以及用于制造其的方法
BR112014028471B1 (pt) Produto fibroso formado em lâmina, material hemostático, material adesivo em tecido orgânico ou material de fechamento de tecido orgânico, e, uso do material hemostático ou do material de fechamento de tecido orgânico
Liu et al. Synthesis of cell composite alginate microfibers by microfluidics with the application potential of small diameter vascular grafts
CN107614093A (zh) 不对称复合膜及其制备中使用的改性衬底
CN105496635A (zh) 一种保水缓释退热贴及其制备方法
Yu et al. Janus Amphipathic Dressing With Liquid Self‐Pumping and Blood‐Clot Anti‐Adhesion for Satisfactory Hemostasis
EP3532659A1 (en) Fibers with segments, their preparation and applications thereof
JP4874973B2 (ja) ポリマーフィルム
JP2020146652A (ja) 濃縮膜
JP2006263721A5 (https=)
Van Oosten et al. Mechanical Properties of Hydrogels
CN105837849A (zh) 一种功能化复合多孔材料的制备方法
US20240327770A1 (en) Cell culture membrane and method for producing biological tissue
ES2443544B1 (es) Material compuesto de ácido hialurónico y al menos un polímero acrílico para aplicaciones biomédicas