JP7188779B2 - 生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子 - Google Patents
生物医学的応用のための制御可能な自己アニーリング型ミクロゲル粒子 Download PDFInfo
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Description
本出願は、2014年7月17日に出願された米国仮特許出願第62/025,844号、2014年10月3日に出願された同第62/059,463号、および2015年1月13日に出願された同第62/103,002号に基づく優先権を主張する。米国特許法第119条によって優先権が主張される。上記特許出願は本明細書に完全に記載されたかの如く参照により援用される。
Claims (26)
- 微小孔性ゲル系であって、当該微小孔性ゲル系が:
架橋ヒドロゲルポリマー骨格を含む複数の球状ミクロゲル粒子を含む水溶液であって、前記架橋ヒドロゲルポリマー骨格が、ポリ(エチレングリコール)(PEG)、RGDペプチド、架橋剤、および1つまたは複数のアニーリング成分を含み、前記1つまたは複数のアニーリング成分が、アクリレート、ビニルスルホン、またはマレイミドを含み、前記球状ミクロゲル粒子が5μm~1000μmの直径を有する水溶液;および
前記複数の球状ミクロゲル粒子に適用された場合に、球状ミクロゲル粒子に、前記1つまたは複数のアニーリング成分を介して共有結合的に安定化した球状ミクロゲル粒子の足場であって、細胞を浸透、遊走および増殖させるのに十分な大きさの相互連結した細孔を有する球状ミクロゲル粒子の足場を形成させるアニーリング剤;
を含むことを特徴とする微小孔性ゲル系。 - 請求項1に記載の微小孔性ゲル系において、前記ポリ(エチレングリコール)PEGが、多腕ポリ(エチレングリコール)PEGビニルスルホンを含むことを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記架橋剤が、(MMP)-分解性架橋剤を含むことを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記架橋剤が、ポリ(エチレングリコール)PEG架橋剤を含むことを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記アニーリング剤が、エオシンYを含むことを特徴とする微小孔性ゲル系。
- 請求項5に記載の微小孔性ゲル系において、前記複数の球状ミクロゲル粒子および前記アニーリング剤の混合物を照射するように構成された光源をさらに備えることを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記共有結合的に安定化した球状ミクロゲル粒子の足場が、約10%~約50%の空隙容量を有することを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、送達デバイスをさらに備えることを特徴とする微小孔性ゲル系。
- 請求項8に記載の微小孔性ゲル系において、前記送達デバイスが、前記複数の球状ミクロゲル粒子およびアニーリング剤またはそこに貯蔵されるアニーリング剤前駆物質を含む水溶液を含むことを特徴とする微小孔性ゲル系。
- 請求項8に記載の微小孔性ゲル系において、前記送達デバイスが、複数区画送達デバイスを備え、一方の区画は、複数の球状ミクロゲル粒子を含む水溶液および第一アニーリング剤前駆物質を備え、第二の区画は、複数の球状ミクロゲル粒子を含む水溶液および第二アニーリング剤前駆物質を備えることを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記球状ミクロゲル粒子が、前記水溶液中で30~99%の体積分率で存在することを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記球状ミクロゲル粒子が、最低で10Paの貯蔵弾性率を有することを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、相互連結した細孔が、約12μm~約37μmの平均孔径によって特徴付けられていることを特徴とする微小孔性ゲル系。
- 請求項1に記載の微小孔性ゲル系において、前記微小孔性ゲル系が、30分以下でアニーリング可能であることを特徴とする微小孔性ゲル系。
- 微小孔性ゲル系であって、当該微小孔性ゲル系が:
架橋ヒドロゲルポリマー骨格を含む複数の球状ミクロゲル粒子を含む水溶液であって、前記架橋ヒドロゲルポリマー骨格が、ヒアルロン酸、RGDペプチド、架橋剤、および1つまたは複数のアニーリング成分を含み、前記1つまたは複数のアニーリング成分が、アクリレート、ビニルスルホン、またはマレイミドを含み、前記球状ミクロゲル粒子が5μm~1000μmの直径を有する水溶液;および
前記複数の球状ミクロゲル粒子に適用された場合に、球状ミクロゲル粒子に、前記1つまたは複数のアニーリング成分を介して共有結合的に安定化した球状ミクロゲル粒子の足場であって、細胞を浸透、遊走および増殖させるのに十分な大きさの相互連結した細孔を有する球状ミクロゲル粒子の足場を形成させるアニーリング剤;
を含むことを特徴とする微小孔性ゲル系。 - 請求項15に記載の微小孔性ゲル系において、前記架橋剤が、(MMP)-分解性架橋剤を含むことを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、前記アニーリング剤が、エオシンYを含むことを特徴とする微小孔性ゲル系。
- 請求項17に記載の微小孔性ゲル系において、前記複数の球状ミクロゲル粒子および前記アニーリング剤の混合物を照射するように構成された光源をさらに備えることを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、前記共有結合的に安定化した球状ミクロゲル粒子の足場が、約10%~約50%の空隙容量を有することを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、送達デバイスをさらに備えることを特徴とする微小孔性ゲル系。
- 請求項20に記載の微小孔性ゲル系において、前記送達デバイスが、前記複数の球状ミクロゲル粒子およびアニーリング剤またはそこに貯蔵されるアニーリング剤前駆物質を含む水溶液を含むことを特徴とする微小孔性ゲル系。
- 請求項20に記載の微小孔性ゲル系において、前記送達デバイスが、複数区画送達デバイスを備え、一方の区画は、複数の球状ミクロゲル粒子を含む水溶液および第一アニーリング剤前駆物質を備え、第二の区画は、複数の球状ミクロゲル粒子を含む水溶液および第二アニーリング剤前駆物質を備えることを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、前記球状ミクロゲル粒子が、前記水溶液中で30~99%の体積分率で存在することを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、前記球状ミクロゲル粒子が、最低で10Paの貯蔵弾性率を有することを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、相互連結した細孔が、約12μm~約37μmの平均孔径によって特徴付けられていることを特徴とする微小孔性ゲル系。
- 請求項15に記載の微小孔性ゲル系において、前記微小孔性ゲル系が、30分以下でアニーリング可能であることを特徴とする微小孔性ゲル系。
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WO2013071126A1 (en) | 2011-11-10 | 2013-05-16 | The Regents Of The University Of California | Enzyme-assisted spatial decoration of biomaterials |
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