IL282559B - Controllable self-annealing microgel particles for biomedical applications - Google Patents
Controllable self-annealing microgel particles for biomedical applicationsInfo
- Publication number
- IL282559B IL282559B IL282559A IL28255921A IL282559B IL 282559 B IL282559 B IL 282559B IL 282559 A IL282559 A IL 282559A IL 28255921 A IL28255921 A IL 28255921A IL 282559 B IL282559 B IL 282559B
- Authority
- IL
- Israel
- Prior art keywords
- microgel particles
- annealing
- microgel
- scaffold
- gel system
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims description 345
- 239000000499 gel Substances 0.000 claims description 137
- 238000000137 annealing Methods 0.000 claims description 135
- 239000004971 Cross linker Substances 0.000 claims description 70
- 239000003795 chemical substances by application Substances 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 40
- 239000011148 porous material Substances 0.000 claims description 27
- 239000007864 aqueous solution Substances 0.000 claims description 26
- 229920001223 polyethylene glycol Polymers 0.000 claims description 25
- -1 poly(ethylene glycol) Polymers 0.000 claims description 24
- 239000000017 hydrogel Substances 0.000 claims description 19
- 229920000642 polymer Polymers 0.000 claims description 18
- 239000002243 precursor Substances 0.000 claims description 17
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims description 15
- 239000011800 void material Substances 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 11
- SEACYXSIPDVVMV-UHFFFAOYSA-L eosin Y Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C([O-])=C(Br)C=C21 SEACYXSIPDVVMV-UHFFFAOYSA-L 0.000 claims description 8
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 claims description 7
- 238000006845 Michael addition reaction Methods 0.000 claims description 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 6
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 4
- 229960003160 hyaluronic acid Drugs 0.000 claims description 4
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 description 135
- 210000004027 cell Anatomy 0.000 description 109
- 208000027418 Wounds and injury Diseases 0.000 description 98
- 206010052428 Wound Diseases 0.000 description 95
- 239000000243 solution Substances 0.000 description 75
- 238000000034 method Methods 0.000 description 59
- 239000003921 oil Substances 0.000 description 49
- 230000015572 biosynthetic process Effects 0.000 description 48
- 235000019198 oils Nutrition 0.000 description 43
- 108090000765 processed proteins & peptides Proteins 0.000 description 37
- 239000000463 material Substances 0.000 description 36
- 238000001727 in vivo Methods 0.000 description 29
- 230000015556 catabolic process Effects 0.000 description 26
- 238000006731 degradation reaction Methods 0.000 description 26
- 102000004196 processed proteins & peptides Human genes 0.000 description 26
- 238000006243 chemical reaction Methods 0.000 description 23
- 239000000126 substance Substances 0.000 description 22
- 239000004094 surface-active agent Substances 0.000 description 21
- 238000000338 in vitro Methods 0.000 description 19
- 238000005516 engineering process Methods 0.000 description 18
- 238000004519 manufacturing process Methods 0.000 description 18
- 230000029663 wound healing Effects 0.000 description 17
- 238000004132 cross linking Methods 0.000 description 16
- 239000011159 matrix material Substances 0.000 description 16
- 230000035876 healing Effects 0.000 description 15
- 238000002347 injection Methods 0.000 description 15
- 239000007924 injection Substances 0.000 description 15
- 230000008569 process Effects 0.000 description 15
- 150000003254 radicals Chemical class 0.000 description 15
- 230000004956 cell adhesive effect Effects 0.000 description 13
- 239000003814 drug Substances 0.000 description 12
- 230000011218 segmentation Effects 0.000 description 12
- 239000002002 slurry Substances 0.000 description 12
- 239000000758 substrate Substances 0.000 description 12
- 230000017423 tissue regeneration Effects 0.000 description 12
- 238000002156 mixing Methods 0.000 description 11
- 102000005741 Metalloproteases Human genes 0.000 description 10
- 108010006035 Metalloproteases Proteins 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 10
- 230000001413 cellular effect Effects 0.000 description 10
- 238000011065 in-situ storage Methods 0.000 description 10
- 230000010354 integration Effects 0.000 description 10
- 239000012620 biological material Substances 0.000 description 9
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 9
- 230000008929 regeneration Effects 0.000 description 9
- 238000011069 regeneration method Methods 0.000 description 9
- 210000003491 skin Anatomy 0.000 description 9
- 238000013459 approach Methods 0.000 description 8
- 230000001684 chronic effect Effects 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 239000007863 gel particle Substances 0.000 description 8
- 238000001879 gelation Methods 0.000 description 8
- 230000008595 infiltration Effects 0.000 description 8
- 238000001764 infiltration Methods 0.000 description 8
- 230000000977 initiatory effect Effects 0.000 description 8
- 230000003993 interaction Effects 0.000 description 8
- 230000035755 proliferation Effects 0.000 description 8
- 239000007787 solid Substances 0.000 description 8
- 238000012546 transfer Methods 0.000 description 8
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 7
- 108090000190 Thrombin Proteins 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 208000014674 injury Diseases 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 238000012986 modification Methods 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 231100000241 scar Toxicity 0.000 description 7
- 108010000196 Factor XIIIa Proteins 0.000 description 6
- 108010073385 Fibrin Proteins 0.000 description 6
- 102000009123 Fibrin Human genes 0.000 description 6
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 6
- 229920001730 Moisture cure polyurethane Polymers 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 6
- 230000012292 cell migration Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 230000002500 effect on skin Effects 0.000 description 6
- 229950003499 fibrin Drugs 0.000 description 6
- 239000012634 fragment Substances 0.000 description 6
- 230000001404 mediated effect Effects 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 229960004072 thrombin Drugs 0.000 description 6
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 5
- 150000008574 D-amino acids Chemical class 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 239000007995 HEPES buffer Substances 0.000 description 5
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 5
- 102100022338 Integrin alpha-M Human genes 0.000 description 5
- 208000034693 Laceration Diseases 0.000 description 5
- 108010038807 Oligopeptides Proteins 0.000 description 5
- 102000015636 Oligopeptides Human genes 0.000 description 5
- 206010072170 Skin wound Diseases 0.000 description 5
- 239000008346 aqueous phase Substances 0.000 description 5
- 230000010261 cell growth Effects 0.000 description 5
- 239000006285 cell suspension Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 230000009969 flowable effect Effects 0.000 description 5
- 239000002105 nanoparticle Substances 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- 230000001172 regenerating effect Effects 0.000 description 5
- 229920001059 synthetic polymer Polymers 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
- 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 4
- 108010016113 Matrix Metalloproteinase 1 Proteins 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- 229940098773 bovine serum albumin Drugs 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 4
- 235000018417 cysteine Nutrition 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 230000002255 enzymatic effect Effects 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 4
- 239000003102 growth factor Substances 0.000 description 4
- 210000003780 hair follicle Anatomy 0.000 description 4
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 230000001976 improved effect Effects 0.000 description 4
- 238000010348 incorporation Methods 0.000 description 4
- 239000003999 initiator Substances 0.000 description 4
- 238000005297 material degradation process Methods 0.000 description 4
- 230000005012 migration Effects 0.000 description 4
- 238000013508 migration Methods 0.000 description 4
- 229920005615 natural polymer Polymers 0.000 description 4
- 230000000269 nucleophilic effect Effects 0.000 description 4
- 210000004940 nucleus Anatomy 0.000 description 4
- 230000000704 physical effect Effects 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- 238000011002 quantification Methods 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000001878 scanning electron micrograph Methods 0.000 description 4
- 230000008733 trauma Effects 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 238000011144 upstream manufacturing Methods 0.000 description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 4
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 206010056340 Diabetic ulcer Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
- 102000005705 Keratin-5 Human genes 0.000 description 3
- 108010070553 Keratin-5 Proteins 0.000 description 3
- 150000008575 L-amino acids Chemical class 0.000 description 3
- 108060008539 Transglutaminase Proteins 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 230000002146 bilateral effect Effects 0.000 description 3
- 239000007975 buffered saline Substances 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 235000011148 calcium chloride Nutrition 0.000 description 3
- 238000005266 casting Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 229920000669 heparin Polymers 0.000 description 3
- 229960002897 heparin Drugs 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 210000003668 pericyte Anatomy 0.000 description 3
- 239000003361 porogen Substances 0.000 description 3
- 239000005060 rubber Substances 0.000 description 3
- 230000037390 scarring Effects 0.000 description 3
- 210000001732 sebaceous gland Anatomy 0.000 description 3
- 230000011664 signaling Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 description 3
- 150000003573 thiols Chemical class 0.000 description 3
- 230000025366 tissue development Effects 0.000 description 3
- 230000008467 tissue growth Effects 0.000 description 3
- 102000003601 transglutaminase Human genes 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- 239000007762 w/o emulsion Substances 0.000 description 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
- 239000012099 Alexa Fluor family Substances 0.000 description 2
- 206010006802 Burns second degree Diseases 0.000 description 2
- 206010006803 Burns third degree Diseases 0.000 description 2
- 108091033409 CRISPR Proteins 0.000 description 2
- 229920001661 Chitosan Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 229920002971 Heparan sulfate Polymers 0.000 description 2
- 238000012404 In vitro experiment Methods 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- KPKZJLCSROULON-QKGLWVMZSA-N Phalloidin Chemical compound N1C(=O)[C@@H]([C@@H](O)C)NC(=O)[C@H](C)NC(=O)[C@H](C[C@@](C)(O)CO)NC(=O)[C@H](C2)NC(=O)[C@H](C)NC(=O)[C@@H]3C[C@H](O)CN3C(=O)[C@@H]1CSC1=C2C2=CC=CC=C2N1 KPKZJLCSROULON-QKGLWVMZSA-N 0.000 description 2
- 229920012266 Poly(ether sulfone) PES Polymers 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 208000004210 Pressure Ulcer Diseases 0.000 description 2
- 208000019155 Radiation injury Diseases 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 208000000558 Varicose Ulcer Diseases 0.000 description 2
- 206010048031 Wound dehiscence Diseases 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229920005601 base polymer Polymers 0.000 description 2
- 230000027455 binding Effects 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 238000001574 biopsy Methods 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 229940045110 chitosan Drugs 0.000 description 2
- 238000004581 coalescence Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 230000009407 collective cell migration Effects 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000000994 depressogenic effect Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002430 laser surgery Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 108020004707 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229920002120 photoresistant polymer Polymers 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
- 239000011535 reaction buffer Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000002407 reforming Methods 0.000 description 2
- 238000010963 scalable process Methods 0.000 description 2
- 239000000565 sealant Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 238000001338 self-assembly Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000012798 spherical particle Substances 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 229920001897 terpolymer Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000009772 tissue formation Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 235000012431 wafers Nutrition 0.000 description 2
- NGXDNMNOQDVTRL-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-(4-azido-2-nitroanilino)hexanoate Chemical compound [O-][N+](=O)C1=CC(N=[N+]=[N-])=CC=C1NCCCCCC(=O)ON1C(=O)CCC1=O NGXDNMNOQDVTRL-UHFFFAOYSA-N 0.000 description 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 description 1
- 101710151806 72 kDa type IV collagenase Proteins 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 238000010354 CRISPR gene editing Methods 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 238000000116 DAPI staining Methods 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 108010071289 Factor XIII Proteins 0.000 description 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 208000008081 Intestinal Fistula Diseases 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- 206010049287 Lipodystrophy acquired Diseases 0.000 description 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100341513 Mus musculus Itgam gene Proteins 0.000 description 1
- 101001056472 Mus musculus Keratin, type II cytoskeletal 5 Proteins 0.000 description 1
- 101001116301 Mus musculus Platelet endothelial cell adhesion molecule Proteins 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical class ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010009711 Phalloidine Proteins 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- 206010034962 Photopsia Diseases 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 206010047363 Vesical fistula Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000009692 acute damage Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 description 1
- 229910001870 ammonium persulfate Inorganic materials 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 239000010426 asphalt Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 229920000249 biocompatible polymer Polymers 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 description 1
- 229960001736 buprenorphine Drugs 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000004709 cell invasion Effects 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 238000006757 chemical reactions by type Methods 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000012650 click reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000000355 continuous-flow lithography Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229920006332 epoxy adhesive Polymers 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 229940012444 factor xiii Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000003176 fibrotic effect Effects 0.000 description 1
- 230000009795 fibrotic process Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000003682 fluorination reaction Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229920000578 graft copolymer Polymers 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 239000013003 healing agent Substances 0.000 description 1
- 210000005003 heart tissue Anatomy 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 238000012188 high-throughput screening assay Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 208000006132 lipodystrophy Diseases 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 description 1
- 238000001000 micrograph Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 102000035118 modified proteins Human genes 0.000 description 1
- 108091005573 modified proteins Proteins 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000011022 opal Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940124583 pain medication Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- BWCCVIRGUMYIHE-UHFFFAOYSA-N phosphane;azide Chemical compound P.[N-]=[N+]=[N-] BWCCVIRGUMYIHE-UHFFFAOYSA-N 0.000 description 1
- 229910000065 phosphene Inorganic materials 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 230000002186 photoactivation Effects 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000070 poly-3-hydroxybutyrate Polymers 0.000 description 1
- 229920001610 polycaprolactone Polymers 0.000 description 1
- 239000004632 polycaprolactone Substances 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229950010131 puromycin Drugs 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009719 regenerative response Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 238000002174 soft lithography Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000000661 stop-flow lithography Methods 0.000 description 1
- 239000003894 surgical glue Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 230000005641 tunneling Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/795—Polymers containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462025844P | 2014-07-17 | 2014-07-17 | |
| US201462059463P | 2014-10-03 | 2014-10-03 | |
| US201562103002P | 2015-01-13 | 2015-01-13 | |
| PCT/US2015/040962 WO2016011387A1 (en) | 2014-07-17 | 2015-07-17 | Controllable self-annealing microgel particles for biomedical applications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL282559A IL282559A (en) | 2021-06-30 |
| IL282559B true IL282559B (en) | 2022-07-01 |
Family
ID=55079098
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL282559A IL282559B (en) | 2014-07-17 | 2015-07-17 | Controllable self-annealing microgel particles for biomedical applications |
| IL250092A IL250092B (en) | 2014-07-17 | 2017-01-12 | Self-reinforced and controllable microgel particles for biomedical applications |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL250092A IL250092B (en) | 2014-07-17 | 2017-01-12 | Self-reinforced and controllable microgel particles for biomedical applications |
Country Status (11)
| Country | Link |
|---|---|
| US (7) | US20160279283A1 (https=) |
| EP (1) | EP3169372B1 (https=) |
| JP (3) | JP6651500B2 (https=) |
| KR (4) | KR102264607B1 (https=) |
| CN (2) | CN111939316B (https=) |
| AU (1) | AU2015289474B2 (https=) |
| BR (1) | BR112017000813B1 (https=) |
| CA (1) | CA2955357A1 (https=) |
| ES (1) | ES3002759T3 (https=) |
| IL (2) | IL282559B (https=) |
| WO (1) | WO2016011387A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009134354A1 (en) | 2008-04-30 | 2009-11-05 | Flanigan Theodore P | System and method for pre-treatment of rubber-modified asphalt cement, and emulsions thereof |
| EP2346940A4 (en) | 2008-09-24 | 2013-04-24 | Wright Advanced Asphalt Systems | SYSTEM AND METHOD FOR THE PRODUCTION OF RUBBER-MODIFIED ASPHALT CEMENT HIGH-PERFORMANCE |
| KR102264607B1 (ko) | 2014-07-17 | 2021-06-14 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자 |
| GB201514788D0 (en) | 2015-08-20 | 2015-10-07 | Ecole Polytech | Malleable scaffold material and uses thereof |
| WO2017136427A1 (en) * | 2016-02-02 | 2017-08-10 | The Regents Of The University Of California | Hydrogel for endogenous neuroprogenitor cell recruitment |
| WO2017142879A1 (en) | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
| ES2989467T3 (es) | 2016-04-08 | 2024-11-26 | Univ California | Hidrogel para la respuesta inmune diseñada a péptidos con D-quiralidad |
| WO2018013726A1 (en) * | 2016-07-12 | 2018-01-18 | Northeastern University | Single cell fluorescence in situ hybridization in microfluidic droplets |
| JP6345736B2 (ja) * | 2016-07-15 | 2018-06-20 | 国立研究開発法人科学技術振興機構 | 液滴安定化装置、液滴分取装置及びそれらの方法 |
| CN110446508A (zh) * | 2016-12-29 | 2019-11-12 | 泰普治疗公司 | 用于治疗医疗植入物部位的方法和系统 |
| WO2018144481A1 (en) | 2017-01-31 | 2018-08-09 | The Regents Of The University Of California | Multi-arm block-copolymers for multifunctional self-assembled systems |
| WO2018156935A1 (en) | 2017-02-24 | 2018-08-30 | The Regents Of The University Of California | Particle-drop structures and methods for making and using the same |
| US11131673B2 (en) | 2017-04-27 | 2021-09-28 | Northeastern University | Live single-cell bioassay in microdroplets |
| US11129790B2 (en) | 2017-05-19 | 2021-09-28 | Northeastern University | Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates |
| US11926091B2 (en) | 2018-03-27 | 2024-03-12 | UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 | In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering |
| CA3097047A1 (en) | 2018-04-13 | 2019-10-17 | University Of Virginia Patent Foundation | Compositions and methods for preparing and using non-immunogenic fast annealing microporous annealed particle hydrogels |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| EP3866867A4 (en) * | 2018-10-18 | 2022-07-13 | The Regents of the University of California | PROCESS FOR THE PREPARATION OF MODULAR HYDROGELS FROM MACROMOLECULES WITH ORTHOGONAL PHYSICOCHEMICAL REACTION |
| ES2969884T3 (es) | 2019-04-02 | 2024-05-23 | Volumina Medical Sa | Composición que comprende un poliol reticulado |
| EP3789049A1 (en) * | 2019-09-06 | 2021-03-10 | QGel SA | Method for obtaining healthy intestinal organoids |
| US20230001055A1 (en) * | 2019-12-06 | 2023-01-05 | University Of Virginia Patent Foundation | Injectable micro-annealed porous scaffold for articular cartilage regeneration |
| WO2021174008A1 (en) * | 2020-02-28 | 2021-09-02 | University Of Florida Research Foundation | Compositions, methods, kits, and systems relating to charge-neutral microgels for 3d cell culture and printing |
| JP2021171180A (ja) * | 2020-04-21 | 2021-11-01 | 株式会社ユニバーサルエンターテインメント | 遊技機 |
| WO2022016013A1 (en) * | 2020-07-16 | 2022-01-20 | The Regents Of The University Of California | Injectable drug-releasing microporous annealed particle scaffolds for treating myocardial infarction |
| US12280540B2 (en) | 2020-09-27 | 2025-04-22 | San Diego State University Research Foundation | In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering |
| US11879118B2 (en) * | 2020-11-10 | 2024-01-23 | C.C. Imex | Gel tray for bacteria transformation lab |
| CA3215070A1 (en) | 2021-04-14 | 2022-10-20 | Joseph DE RUTTE | Nanoscale reaction chambers and methods of using the same |
| CA3220391A1 (en) * | 2021-05-27 | 2022-12-01 | Charles Blaha | Superporous gel matrix for encapsulation of cells |
| EP4373899A4 (en) * | 2021-07-21 | 2026-01-14 | Harvard College | METHODS FOR CROSS-CROSSING POLYMERS AND HYDROGEL MICROPARTICLES AND FOR ENCAPSULATING BIOLOGICALLY ACTIVE COMPOUNDS, COMPOSITIONS PRODUCED FROM THESE AND DEVICES |
| KR20230059380A (ko) * | 2021-10-26 | 2023-05-03 | 강원대학교산학협력단 | 피부 복원용 3차원 스캐폴드 |
| US20250205392A1 (en) * | 2022-03-29 | 2025-06-26 | The Penn State Research Foundation | Device and method for accelerating and guiding vascularization |
| WO2024015656A1 (en) * | 2022-07-11 | 2024-01-18 | The Regents Of The University Of California | Cell-microgel encapsulation in injectable formulations |
| US20240026088A1 (en) | 2022-07-19 | 2024-01-25 | CellDrop Biosciences, Inc. | Hydrogel Particle Encapsulation and Suspension Media Removal |
| US20260051184A1 (en) * | 2022-08-04 | 2026-02-19 | Duke University | Systems and methods for analysis of microporous annealed particle scaffolds |
| WO2024036108A1 (en) * | 2022-08-09 | 2024-02-15 | Bionaut Labs Ltd. | Devices, systems, and methods for the treatment of malignant neoplasm disorders using controlled release devices |
| CN116077736A (zh) * | 2022-09-26 | 2023-05-09 | 四川大学 | 基于多孔明胶复合微球的可注射骨修复支架及其制备方法 |
| WO2025054490A1 (en) * | 2023-09-08 | 2025-03-13 | Rasyn, Llc | Multi-omic analysis using beyond-poisson droplet loading |
| CN117462751A (zh) * | 2023-10-30 | 2024-01-30 | 南京鼓楼医院 | 一种甲基丙烯酰化明胶微孔退火颗粒支架及其制备方法 |
| WO2025096900A1 (en) * | 2023-11-03 | 2025-05-08 | Board Of Regents, The University Of Texas System | Synthetic network materials and methods of making and use thereof |
| WO2025247844A1 (en) | 2024-05-28 | 2025-12-04 | Eth Zurich | Granular hydrogel combinations for wound healing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080193536A1 (en) * | 2006-08-14 | 2008-08-14 | Alireza Khademhosseini | Cell-Laden Hydrogels |
| WO2011101684A1 (en) * | 2010-02-19 | 2011-08-25 | The University Of Manchester | Microgel compositions |
| WO2013071126A1 (en) * | 2011-11-10 | 2013-05-16 | The Regents Of The University Of California | Enzyme-assisted spatial decoration of biomaterials |
| WO2016011387A1 (en) * | 2014-07-17 | 2016-01-21 | The Regents Of The University Of California | Controllable self-annealing microgel particles for biomedical applications |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4726877A (en) * | 1986-01-22 | 1988-02-23 | E. I. Du Pont De Nemours And Company | Methods of using photosensitive compositions containing microgels |
| US4753865A (en) | 1986-01-22 | 1988-06-28 | E. I. Du Pont De Nemours And Company | Photosensitive compositions containing microgels |
| US5843156A (en) | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| US5213580A (en) | 1988-08-24 | 1993-05-25 | Endoluminal Therapeutics, Inc. | Biodegradable polymeric endoluminal sealing process |
| US5575815A (en) | 1988-08-24 | 1996-11-19 | Endoluminal Therapeutics, Inc. | Local polymeric gel therapy |
| US5124188A (en) | 1990-04-02 | 1992-06-23 | The Procter & Gamble Company | Porous, absorbent, polymeric macrostructures and methods of making the same |
| KR100266912B1 (ko) | 1992-02-28 | 2000-12-01 | 파라비 레이 | 조직접촉물질이며 방출조절운반체인 광중합성 생분해성 하이드로겔 |
| JP3156955B2 (ja) * | 1995-07-12 | 2001-04-16 | 大日精化工業株式会社 | 連結されたミクロゲル粒子の製造方法及びそれで処理された物品 |
| US6066325A (en) * | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US8603511B2 (en) | 1996-08-27 | 2013-12-10 | Baxter International, Inc. | Fragmented polymeric compositions and methods for their use |
| US6063061A (en) * | 1996-08-27 | 2000-05-16 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
| US20020064546A1 (en) | 1996-09-13 | 2002-05-30 | J. Milton Harris | Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor |
| US6316522B1 (en) | 1997-08-18 | 2001-11-13 | Scimed Life Systems, Inc. | Bioresorbable hydrogel compositions for implantable prostheses |
| US5854382A (en) | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
| US6007833A (en) | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
| US7547445B2 (en) | 1998-03-19 | 2009-06-16 | Surmodics, Inc. | Crosslinkable macromers |
| US6410044B1 (en) | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
| US6152943A (en) | 1998-08-14 | 2000-11-28 | Incept Llc | Methods and apparatus for intraluminal deposition of hydrogels |
| KR100683603B1 (ko) | 1998-10-23 | 2007-02-20 | 폴리힐 엘티디. | 창상 치유용 미소구 조성물 |
| US7615373B2 (en) * | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
| AU7084300A (en) | 1999-08-27 | 2001-03-26 | Cohesion Technologies, Inc. | Compositions that form interpenetrating polymer networks for use as high strength medical sealants |
| JP4485124B2 (ja) | 2000-11-17 | 2010-06-16 | ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション | 電気処理されたコラーゲン |
| US6878384B2 (en) | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
| US6669827B2 (en) | 2001-06-18 | 2003-12-30 | Austin & Neff, L.L.C. | Systems and methods for affecting the ultra-fast photodissociation of water molecules |
| GB0115320D0 (en) | 2001-06-22 | 2001-08-15 | Univ Nottingham | Matrix |
| US20040258731A1 (en) | 2001-11-21 | 2004-12-23 | Tsuyoshi Shimoboji | Preparation approriate for cartilage tissue formation |
| US7745532B2 (en) | 2002-08-02 | 2010-06-29 | Cambridge Polymer Group, Inc. | Systems and methods for controlling and forming polymer gels |
| US20040147016A1 (en) | 2002-09-30 | 2004-07-29 | Rowley Jonathan A. | Programmable scaffold and methods for making and using the same |
| US8574204B2 (en) | 2002-10-21 | 2013-11-05 | Angiodynamics, Inc. | Implantable medical device for improved placement and adherence in the body |
| CA2517204A1 (en) * | 2003-03-13 | 2004-09-23 | Eugenia Kumacheva | Method of producing hybrid polymer-inorganic materials |
| EP1652019A2 (en) | 2003-06-30 | 2006-05-03 | Nupower Semiconductor, Inc. | Programmable calibration circuit for power supply current sensing and droop loss compensation |
| WO2005032418A2 (en) | 2003-10-01 | 2005-04-14 | University Of Washington | Novel porous biomaterials |
| ATE524203T1 (de) | 2003-11-03 | 2011-09-15 | Medtronic Inc | Hydrogel für zellspezifisches einwachsen |
| AU2005318097A1 (en) * | 2004-12-22 | 2006-06-29 | Kuros Biosurgery Ag | Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors |
| WO2007044669A2 (en) | 2005-10-07 | 2007-04-19 | Lonza Walkersville, Inc. | Engineered biological matrices |
| GB2431104A (en) | 2005-10-10 | 2007-04-18 | Univ Greenwich | Microgel particles grafted to a substrate |
| US9132208B2 (en) * | 2008-08-07 | 2015-09-15 | Lifenet Health | Composition for a tissue repair implant and methods of making the same |
| US8029575B2 (en) | 2005-10-25 | 2011-10-04 | Globus Medical, Inc. | Porous and nonporous materials for tissue grafting and repair |
| PT2347775T (pt) * | 2005-12-13 | 2020-07-14 | The President And Fellows Of Harvard College | Estruturas em andaime para transplante celular |
| EP1808187A1 (en) * | 2006-01-11 | 2007-07-18 | Straumann Holding AG | Cell selective implant surface with controlled release of bioactive agents |
| CN101410098B (zh) | 2006-01-23 | 2012-01-18 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 包括含亲脂性药物的纳米胶囊的微球 |
| US20070212385A1 (en) | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
| DE102006040772A1 (de) | 2006-08-31 | 2008-03-20 | Kist-Europe Forschungsgesellschaft Mbh | Polymermatrix, Verfahren zu deren Herstellung sowie deren Verwendung |
| GB0701896D0 (en) * | 2007-02-01 | 2007-03-14 | Regentec Ltd | Composition |
| US8277832B2 (en) * | 2007-10-10 | 2012-10-02 | The University Of Kansas | Microsphere-based materials with predefined 3D spatial and temporal control of biomaterials, porosity and/or bioactive signals |
| US20090294049A1 (en) | 2008-06-02 | 2009-12-03 | Medtronic Vascular, Inc. | Biodegradable Adhesive Hydrogels |
| JP2012501965A (ja) | 2008-06-16 | 2012-01-26 | バインド バイオサイエンシズ インコーポレイテッド | 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法 |
| US8557288B2 (en) | 2008-08-15 | 2013-10-15 | Washington University | Hydrogel microparticle formation in aqueous solvent for biomedical applications |
| US20120015440A1 (en) | 2008-09-08 | 2012-01-19 | Tokyo University Of Science Educational Foundation Administrative Org. | Spheroid composite, spheroid-containing hydrogel and processes for production of same |
| US11090387B2 (en) | 2008-12-22 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Hydrolytically degradable polysaccharide hydrogels |
| CN102573913B (zh) | 2009-07-31 | 2014-06-18 | 阿森迪斯药物股份有限公司 | 可生物降解的基于聚乙二醇的水不溶性水凝胶 |
| AU2010325158B2 (en) | 2009-11-25 | 2014-09-04 | Healionics Corporation | Granules of porous biocompatible materials |
| WO2011127395A1 (en) | 2010-04-08 | 2011-10-13 | Healionics Corporation | Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same |
| US20110256628A1 (en) | 2010-04-20 | 2011-10-20 | The University Of Washington Through Its Center For Commercialization | Adaptive tissue engineering scaffold |
| US8524215B2 (en) | 2010-08-02 | 2013-09-03 | Janssen Biotech, Inc. | Absorbable PEG-based hydrogels |
| JP6104806B2 (ja) * | 2010-10-06 | 2017-03-29 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 材料に基づく細胞治療のための注射可能孔形成性ハイドロゲル |
| EP2641094B1 (en) | 2010-11-18 | 2019-03-06 | The Regents of The University of California | Method for high-throughput solution exchange for cell and particle suspensions |
| WO2012068003A2 (en) | 2010-11-18 | 2012-05-24 | The Regents Of The University Of California | Particle focusing systems and methods |
| US9234171B2 (en) | 2010-12-08 | 2016-01-12 | Rutgers, The State University Of New Jersey | Stem cell differentiation using novel light-responsive hydrogels |
| US20120202263A1 (en) | 2011-02-03 | 2012-08-09 | The Trustees Of The University Of Pennsylvania | Bioactive Macromers and Hydrogels and Methods for Producing Same |
| US10260039B2 (en) * | 2011-05-11 | 2019-04-16 | Massachusetts Institute Of Technology | Microgels and microtissues for use in tissue engineering |
| WO2012170706A2 (en) | 2011-06-08 | 2012-12-13 | Surmodics, Inc. | Photo-vinyl linking agents |
| WO2013033717A1 (en) | 2011-09-02 | 2013-03-07 | The Regents Of The University Of California | Enzyme responsive nanocapsules for protein delivery |
| JP6075735B2 (ja) | 2011-09-30 | 2017-02-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 配列された微小構造を用いて流体流れをプログラムするデバイスおよび方法 |
| KR101820792B1 (ko) * | 2011-12-20 | 2018-01-23 | 한온시스템 주식회사 | 차량 공조장치용 컨트롤러 |
| US9974886B2 (en) * | 2012-08-08 | 2018-05-22 | Nanyang Technological University | Methods of manufacturing hydrogel microparticles having living cells, and compositions for manufacturing a scaffold for tissue engineering |
| US10201613B2 (en) | 2012-09-07 | 2019-02-12 | The Regents Of The University Of California | Method of creating hydrogels through oxime bond formation |
| US9364543B2 (en) | 2012-10-24 | 2016-06-14 | Indiana University Research And Technology Corporation | Visible light curable hydrogels and methods for using |
| EP2801613A1 (en) | 2013-05-08 | 2014-11-12 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Arrays of discrete cell culture microenvironments, methods of making such arrays and uses thereof |
| US9381217B2 (en) | 2013-09-09 | 2016-07-05 | Georgia Tech Research Corporation | Microgels for encapsulation of cells and other biologic agents |
| US20150290362A1 (en) | 2014-04-10 | 2015-10-15 | Georgia Tech Research Corporation | Hybrid fibrin-microgel constructs for tissue repair and regeneration |
| WO2016096054A1 (en) | 2014-12-19 | 2016-06-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method and device for mixing two streams of droplets |
| US20160303281A1 (en) | 2015-04-17 | 2016-10-20 | Rochal Industries, Llc | Composition and kits for pseudoplastic microgel matrices |
| US20200305773A1 (en) | 2016-01-21 | 2020-10-01 | The Regents Of The University Of California | Device and method for analyte sensing with microporous annealed particle gels |
| WO2017136427A1 (en) | 2016-02-02 | 2017-08-10 | The Regents Of The University Of California | Hydrogel for endogenous neuroprogenitor cell recruitment |
| WO2017142879A1 (en) | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
| CN110446508A (zh) | 2016-12-29 | 2019-11-12 | 泰普治疗公司 | 用于治疗医疗植入物部位的方法和系统 |
-
2015
- 2015-07-17 KR KR1020177004012A patent/KR102264607B1/ko active Active
- 2015-07-17 WO PCT/US2015/040962 patent/WO2016011387A1/en not_active Ceased
- 2015-07-17 AU AU2015289474A patent/AU2015289474B2/en active Active
- 2015-07-17 ES ES15821310T patent/ES3002759T3/es active Active
- 2015-07-17 KR KR1020237043035A patent/KR102758574B1/ko active Active
- 2015-07-17 KR KR1020217017499A patent/KR102421923B1/ko active Active
- 2015-07-17 KR KR1020227024066A patent/KR102614915B1/ko active Active
- 2015-07-17 BR BR112017000813-0A patent/BR112017000813B1/pt active IP Right Grant
- 2015-07-17 CN CN202010830676.9A patent/CN111939316B/zh active Active
- 2015-07-17 CN CN201580049478.6A patent/CN106714854B/zh active Active
- 2015-07-17 EP EP15821310.8A patent/EP3169372B1/en active Active
- 2015-07-17 JP JP2017502712A patent/JP6651500B2/ja active Active
- 2015-07-17 IL IL282559A patent/IL282559B/en unknown
- 2015-07-17 CA CA2955357A patent/CA2955357A1/en active Pending
-
2016
- 2016-06-10 US US15/179,151 patent/US20160279283A1/en not_active Abandoned
-
2017
- 2017-01-12 IL IL250092A patent/IL250092B/en active IP Right Grant
- 2017-09-11 US US15/701,113 patent/US10912860B2/en active Active
- 2017-12-01 US US15/829,440 patent/US20180078671A1/en not_active Abandoned
-
2019
- 2019-01-31 US US16/264,466 patent/US20190151497A1/en not_active Abandoned
- 2019-10-08 US US16/596,312 patent/US20200085859A1/en not_active Abandoned
-
2020
- 2020-01-22 JP JP2020008247A patent/JP7188779B2/ja active Active
-
2021
- 2021-01-08 US US17/144,158 patent/US11464886B2/en active Active
-
2022
- 2022-08-26 JP JP2022134723A patent/JP7627498B2/ja active Active
- 2022-09-24 US US17/935,096 patent/US20230190995A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080193536A1 (en) * | 2006-08-14 | 2008-08-14 | Alireza Khademhosseini | Cell-Laden Hydrogels |
| WO2011101684A1 (en) * | 2010-02-19 | 2011-08-25 | The University Of Manchester | Microgel compositions |
| WO2013071126A1 (en) * | 2011-11-10 | 2013-05-16 | The Regents Of The University Of California | Enzyme-assisted spatial decoration of biomaterials |
| WO2016011387A1 (en) * | 2014-07-17 | 2016-01-21 | The Regents Of The University Of California | Controllable self-annealing microgel particles for biomedical applications |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11464886B2 (en) | Controllable self-annealing microgel particles for biomedical applications | |
| Sanz-Horta et al. | Technological advances in fibrin for tissue engineering | |
| Singh et al. | Natural polymer-based hydrogels as scaffolds for tissue engineering | |
| Tallawi et al. | Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review | |
| Meco et al. | Impact of elastin-like protein temperature transition on PEG-ELP hybrid hydrogel properties | |
| US20190060522A1 (en) | Natural Polymer-Derived Scaffold Material and Methods for Production Thereof | |
| US10849988B2 (en) | Hydrogel for engineered immune response to D-chirality peptides | |
| US20230293438A1 (en) | Injectable drug-releasing microporous annealed particle scaffolds for treating myocardial infarction | |
| Miwa | Optimization of Particle-based Hydrogel Biophysical and Biochemical Properties for Biomedical Applications | |
| Kyburz | Bio-Functionalized PEG Hydrogels to Study and Direct Mesenchymal Stem Cell Migration and Differentiation |