JP2017518306A5 - - Google Patents
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- Publication number
- JP2017518306A5 JP2017518306A5 JP2016570860A JP2016570860A JP2017518306A5 JP 2017518306 A5 JP2017518306 A5 JP 2017518306A5 JP 2016570860 A JP2016570860 A JP 2016570860A JP 2016570860 A JP2016570860 A JP 2016570860A JP 2017518306 A5 JP2017518306 A5 JP 2017518306A5
- Authority
- JP
- Japan
- Prior art keywords
- nicotinamide riboside
- chloride
- ion
- tetrahydrofuran
- isomerically pure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462006434P | 2014-06-02 | 2014-06-02 | |
| US62/006,434 | 2014-06-02 | ||
| PCT/IB2015/054181 WO2015186068A1 (en) | 2014-06-02 | 2015-06-02 | Preparation and use of crystalline beta-d-nicotinamide riboside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017518306A JP2017518306A (ja) | 2017-07-06 |
| JP2017518306A5 true JP2017518306A5 (cg-RX-API-DMAC7.html) | 2018-07-12 |
Family
ID=53276953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570860A Pending JP2017518306A (ja) | 2014-06-02 | 2015-06-02 | 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10316054B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3149016A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017518306A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170012449A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106536535A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015270130A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2950727A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016015997A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2016149764A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015186068A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106715454B (zh) * | 2014-07-24 | 2020-06-16 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| FI3268379T3 (fi) * | 2015-03-09 | 2023-12-15 | Grace W R & Co | Nikotiiniamidiribosidin kiteinen muoto |
| KR102354784B1 (ko) | 2015-08-05 | 2022-01-25 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 |
| EP3347024A2 (en) * | 2015-09-08 | 2018-07-18 | Ecole Polytechnique Federale de Lausanne (EPFL) | Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| WO2017079195A1 (en) | 2015-11-02 | 2017-05-11 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
| ES2981479T3 (es) * | 2016-04-14 | 2024-10-09 | Chromadex Inc | Fórmula para lactantes que comprende ribósido de nicotinamida |
| GB2553001A (en) * | 2016-08-19 | 2018-02-21 | The Queen's Univ Of Belfast | Lactone intermediates of nicotinamide riboside and nicotinate riboside |
| CN109982706A (zh) * | 2016-08-22 | 2019-07-05 | 益力舒健康公司 | 用于治疗神经退行性病症的烟酰胺核苷和紫檀芪的组合物和方法 |
| WO2018089830A1 (en) * | 2016-11-11 | 2018-05-17 | The Queen's University Of Belfast | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| BR112019010607B1 (pt) | 2016-11-29 | 2023-10-31 | University Of Iowa Research Foundation | Uso de precursores de nad e composição compreendendo os referidos precursores |
| WO2018132833A1 (en) * | 2017-01-13 | 2018-07-19 | The Regents Of The University Of Colorado, A Body Corporate | Methods for treating hypertension and arterial stiffness |
| WO2018200356A1 (en) * | 2017-04-24 | 2018-11-01 | Elysium Health, Inc. | Treating and preventing kidney damage |
| CN111093676A (zh) * | 2017-05-18 | 2020-05-01 | 益力舒健康公司 | 改善睡眠的方法和组合物 |
| EP3642214A2 (en) | 2017-06-19 | 2020-04-29 | Gangadhara Ganapati | Nicotinamide riboside derivatives and their uses |
| WO2018236747A1 (en) * | 2017-06-21 | 2018-12-27 | Yale University | Compounds and compositions for extending lifespan of a subject |
| JP2020526511A (ja) * | 2017-06-30 | 2020-08-31 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシドの合成方法 |
| KR101990681B1 (ko) * | 2017-07-05 | 2019-06-18 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| KR101982923B1 (ko) * | 2017-07-05 | 2019-05-27 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| US11414407B2 (en) | 2017-12-22 | 2022-08-16 | Elysium Health, Inc. | Crystalline forms of nicotinamide riboside chloride |
| WO2019133815A1 (en) | 2017-12-28 | 2019-07-04 | Kansas State University Research Foundation | Nicotinamide riboside treatments of domesticated meat animals |
| WO2019152416A1 (en) | 2018-01-30 | 2019-08-08 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN110283221A (zh) * | 2018-03-19 | 2019-09-27 | 药源药物化学（上海）有限公司 | 杂环化合物的制备和纯化方法 |
| WO2019209840A1 (en) * | 2018-04-23 | 2019-10-31 | Elysium Health, Inc. | Methods and compositions for treating rheumatoid arthritis |
| CN110452277A (zh) * | 2018-05-07 | 2019-11-15 | 明特奇点医疗科技(成都)有限公司 | 一种烟酰胺核糖的制备方法 |
| JP7160946B2 (ja) * | 2018-05-18 | 2022-10-25 | エフ．ホフマン－ラ ロシュ アーゲー | （チオ）ニコチンアミドリボフラノシド塩および組成物、製造方法、およびそれらの使用 |
| US20210267251A1 (en) | 2018-06-21 | 2021-09-02 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| US11833167B2 (en) | 2018-12-17 | 2023-12-05 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
| US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
| WO2020257283A1 (en) | 2019-06-18 | 2020-12-24 | Mitopower Llc | Nicotinyl riboside compounds and their uses |
| CA3148300A1 (en) | 2019-07-19 | 2021-01-28 | Biosynth Ag | Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof |
| CA3156687A1 (en) * | 2019-11-01 | 2021-05-06 | Jotiram PALKAR | Synergistic nutritional compositions for treating cerebrovascular diseases |
| WO2021180740A1 (en) * | 2020-03-09 | 2021-09-16 | Société des Produits Nestlé S.A. | Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of lung diseases and conditions |
| CN111454311B (zh) | 2020-04-03 | 2021-10-19 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其组合物与制备方法 |
| WO2021253362A1 (zh) * | 2020-06-19 | 2021-12-23 | 邦泰生物工程(深圳)有限公司 | 一种以烟酰胺为原料制备烟酰胺单核苷酸的方法 |
| CN111808156A (zh) * | 2020-07-15 | 2020-10-23 | 许昌远志生物科技有限公司 | 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法 |
| WO2022047182A1 (en) * | 2020-08-28 | 2022-03-03 | University Of Washington | High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation |
| CN112028954B (zh) * | 2020-09-14 | 2022-04-29 | 浩宇康宁健康科技（湖北）有限公司 | 烟酰胺核糖的制备方法 |
| US20240059727A1 (en) * | 2021-01-19 | 2024-02-22 | Biosynth Ag | Method of making nicotinamide ribofuranoside salts by salt metathesis, the crystalline form of its tosylate salt and the co-crystallized form of its chloride:iodide salt |
| US20220241305A1 (en) * | 2021-01-29 | 2022-08-04 | ChromaDex Inc. | Ethyl cellulose based coatings for microencapsulation of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives |
| IL308577A (en) | 2021-05-27 | 2024-01-01 | Metro Int Biotech Llc | Crystalline solids of nicotinic acid mononucleotides and their esters and methods for their preparation and use |
| CN113943333B (zh) * | 2021-10-09 | 2023-07-14 | 广东生命源科技有限公司 | 一种氢化烟酰胺核糖的制备方法及应用 |
| EP4422644A4 (en) * | 2021-10-27 | 2025-08-27 | Elysium Health Inc | METHODS OF TREATING MENOPAUSAL SYNDROMES |
| CN118613472A (zh) * | 2022-01-31 | 2024-09-06 | 新前沿生物公司 | 基于烟酸酯和烟酰胺核苷的化合物及其衍生物 |
| CN114577935B (zh) * | 2022-03-03 | 2024-07-23 | 中科谱研（北京）科技有限公司 | 一种胶囊中烟酰胺核糖氯化物的分离检测方法 |
| CN118765281A (zh) * | 2022-03-15 | 2024-10-11 | 可劳迈戴斯有限公司 | 产生结晶β烟酰胺核苷三乙酸酯氯化物的方法 |
| CN116621898A (zh) * | 2022-04-13 | 2023-08-22 | 深圳市迪克曼科技开发有限公司 | 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途 |
| CN115287278B (zh) * | 2022-06-17 | 2023-11-10 | 武汉真福医药股份有限公司 | 一种枯草芽孢杆菌纤溶酶及其制备方法和抗氧化溶血栓组合物 |
| CN120603587A (zh) | 2023-02-01 | 2025-09-05 | 博迪贺康(绍兴)生物技术有限公司 | 一种化合物及其应用 |
| CN116655528B (zh) * | 2023-04-28 | 2025-12-02 | 宁波百思佳医药科技有限公司 | 一种氯化1-甲基烟酰铵的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288089B1 (en) | 1998-12-21 | 2001-09-11 | Michael Zawada | Use of kinase inhibitors for treating neurodegenerative diseases |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050096256A1 (en) | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| US20060229265A1 (en) | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
| AU2006278397B2 (en) | 2005-08-04 | 2013-01-17 | Sirtris Pharmaceuticals, Inc. | Oxazolopyridine derivatives as sirtuin modulators |
| CL2008001821A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de imidazo[2,1-b]-tiazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de diabetes, sindrome metabolico, resistencia a la insulina, entre otras. |
| CL2008001822A1 (es) | 2007-06-20 | 2009-03-13 | Sirtris Pharmaceuticals Inc | Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras. |
| SG190603A1 (en) | 2008-05-01 | 2013-06-28 | Sirtris Pharmaceuticals Inc | Quinolines and related analogs as sirtuin modulators |
| MX2011000079A (es) | 2008-07-03 | 2011-03-02 | Sirtris Pharmaceuticals Inc | Bencimidazoles y analogos relacionados como moduladores de sirtuin. |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| MX2011006555A (es) | 2008-12-19 | 2011-08-03 | Sirtris Pharmaceuticals Inc | Compuestos de tiazolopiridina moduladores de sirtuina. |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| EP2768834B1 (en) | 2011-10-20 | 2016-04-27 | Glaxosmithkline LLC | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| CN104394869A (zh) | 2011-10-20 | 2015-03-04 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的双环氮杂杂环化合物和类似物 |
| RU2014120180A (ru) | 2011-10-20 | 2015-11-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина |
| GB201313465D0 (en) * | 2013-07-29 | 2013-09-11 | Queens University Of The Belfast | Methods of preparing nicotinamide riboside and derivatives thereof |
| CN105873937A (zh) * | 2013-10-30 | 2016-08-17 | 可劳迈戴斯有限公司 | 用于在治疗皮肤病中局部使用的烟酰胺核苷组合物 |
-
2015
- 2015-06-02 US US15/315,068 patent/US10316054B2/en not_active Expired - Fee Related
- 2015-06-02 JP JP2016570860A patent/JP2017518306A/ja active Pending
- 2015-06-02 CN CN201580040316.6A patent/CN106536535A/zh active Pending
- 2015-06-02 CA CA2950727A patent/CA2950727A1/en not_active Abandoned
- 2015-06-02 AU AU2015270130A patent/AU2015270130A1/en not_active Abandoned
- 2015-06-02 KR KR1020167036649A patent/KR20170012449A/ko not_active Withdrawn
- 2015-06-02 WO PCT/IB2015/054181 patent/WO2015186068A1/en not_active Ceased
- 2015-06-02 EP EP15726738.6A patent/EP3149016A1/en not_active Withdrawn
- 2015-06-02 MX MX2016015997A patent/MX2016015997A/es unknown
- 2015-06-02 RU RU2016149764A patent/RU2016149764A/ru unknown
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