CA2950727A1 - Preparation and use of crystalline beta-d-nicotinamide riboside - Google Patents
Preparation and use of crystalline beta-d-nicotinamide riboside Download PDFInfo
- Publication number
- CA2950727A1 CA2950727A1 CA2950727A CA2950727A CA2950727A1 CA 2950727 A1 CA2950727 A1 CA 2950727A1 CA 2950727 A CA2950727 A CA 2950727A CA 2950727 A CA2950727 A CA 2950727A CA 2950727 A1 CA2950727 A1 CA 2950727A1
- Authority
- CA
- Canada
- Prior art keywords
- nicotinamide riboside
- beta
- chloride
- pyridin
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000002360 preparation method Methods 0.000 title abstract description 101
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 125
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- YABIFCKURFRPPO-IVOJBTPCSA-N 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride Chemical compound [Cl-].NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 YABIFCKURFRPPO-IVOJBTPCSA-N 0.000 claims description 111
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- 229910019142 PO4 Inorganic materials 0.000 claims description 3
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| PCT/IB2015/054181 WO2015186068A1 (en) | 2014-06-02 | 2015-06-02 | Preparation and use of crystalline beta-d-nicotinamide riboside |
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| EP3174891B1 (en) * | 2014-07-24 | 2020-01-29 | W.R. Grace & CO. - CONN. | Crystalline form of nicotinamide riboside |
| CN107428791B (zh) * | 2015-03-09 | 2024-05-28 | 格雷斯公司 | 烟酰胺核苷的结晶形式 |
| EP3331894B1 (en) | 2015-08-05 | 2021-02-17 | Metro International Biotech, LLC | Nicotinamide mononucleotide derivatives and their uses |
| US10905704B2 (en) | 2015-09-08 | 2021-02-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Agents and methods using thereof for the prevention and treatment of stem cell muscle disorders |
| GB2542881B (en) | 2015-10-02 | 2020-01-01 | Carr Andrew | Crystal forms of ß-nicotinamide mononucleotide |
| US10611790B2 (en) | 2015-11-02 | 2020-04-07 | Mitobridge, Inc. | Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases |
| BR112018071074B1 (pt) | 2016-04-14 | 2023-10-03 | Chromadex Inc | Fórmula infantil |
| GB2553001A (en) * | 2016-08-19 | 2018-02-21 | The Queen's Univ Of Belfast | Lactone intermediates of nicotinamide riboside and nicotinate riboside |
| BR112019003579A2 (pt) | 2016-08-22 | 2019-05-21 | Elysium Health, Inc. | Composições de ribosídeo de nicotinamida e pterostilbeno e métodos para o tratamento dedistúrbios neurodegenerativos |
| NZ803738A (en) * | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| BR112019010607B1 (pt) | 2016-11-29 | 2023-10-31 | University Of Iowa Research Foundation | Uso de precursores de nad e composição compreendendo os referidos precursores |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| US20200121704A1 (en) * | 2017-01-13 | 2020-04-23 | The Regents Of The University Of Colorado, A Body Corporate | Methods for treating hypertension and arterial stiffness |
| US11129843B2 (en) | 2017-04-24 | 2021-09-28 | Elysium Health, Inc. | Treating and preventing kidney damage |
| EP3624808A4 (en) * | 2017-05-18 | 2021-03-03 | Elysium Health, Inc. | PROCEDURES AND COMPOSITIONS FOR IMPROVED SLEEP |
| US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
| WO2018236747A1 (en) * | 2017-06-21 | 2018-12-27 | Yale University | Compounds and compositions for extending lifespan of a subject |
| WO2019006262A1 (en) * | 2017-06-30 | 2019-01-03 | Elysium Health, Inc. | METHODS OF SYNTHESIZING NICOTINAMIDE RIBOSIDE |
| KR101990681B1 (ko) * | 2017-07-05 | 2019-06-18 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| KR101982923B1 (ko) * | 2017-07-05 | 2019-05-27 | 가천대학교 산학협력단 | 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법 |
| EP3727400A4 (en) * | 2017-12-22 | 2021-10-20 | Elysium Health, Inc. | CRYSTALLINE FORMS OF NICOTINAMIDE RIBOSIDE CHLORIDE |
| WO2019133815A1 (en) * | 2017-12-28 | 2019-07-04 | Kansas State University Research Foundation | Nicotinamide riboside treatments of domesticated meat animals |
| AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
| CN110283221A (zh) * | 2018-03-19 | 2019-09-27 | 药源药物化学（上海）有限公司 | 杂环化合物的制备和纯化方法 |
| WO2019209840A1 (en) * | 2018-04-23 | 2019-10-31 | Elysium Health, Inc. | Methods and compositions for treating rheumatoid arthritis |
| CN110452277A (zh) * | 2018-05-07 | 2019-11-15 | 明特奇点医疗科技(成都)有限公司 | 一种烟酰胺核糖的制备方法 |
| US11447514B2 (en) | 2018-05-18 | 2022-09-20 | Roche Diagnostics Operations, Inc. | (Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof |
| US20210267251A1 (en) | 2018-06-21 | 2021-09-02 | Societe Des Produits Nestle S.A. | Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor |
| CN108774278A (zh) * | 2018-09-10 | 2018-11-09 | 张洪喜 | 一种制备尼克酰胺核苷盐的方法 |
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| EP4656189A1 (en) | 2023-02-01 | 2025-12-03 | Benethera (Shaoxing) Biotechnology Co., Ltd. | Compound and use thereof |
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| WO2015186068A1 (en) | 2015-12-10 |
| EP3149016A1 (en) | 2017-04-05 |
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