JP2017518306A - 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 - Google Patents

結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 Download PDF

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JP2017518306A
JP2017518306A JP2016570860A JP2016570860A JP2017518306A JP 2017518306 A JP2017518306 A JP 2017518306A JP 2016570860 A JP2016570860 A JP 2016570860A JP 2016570860 A JP2016570860 A JP 2016570860A JP 2017518306 A JP2017518306 A JP 2017518306A
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nicotinamide riboside
chloride
pyridin
disease
ion
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JP2017518306A5 (cg-RX-API-DMAC7.html
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ブルース、シチェパンキーウィクス
カルステン、コペッチュ
ロバート、ビー．ペルニ
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
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    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Diabetes (AREA)
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  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Otolaryngology (AREA)
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JP2016570860A 2014-06-02 2015-06-02 結晶性β−Ｄ−ニコチンアミドリボシドの製造および使用 Pending JP2017518306A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462006434P 2014-06-02 2014-06-02
US62/006,434 2014-06-02
PCT/IB2015/054181 WO2015186068A1 (en) 2014-06-02 2015-06-02 Preparation and use of crystalline beta-d-nicotinamide riboside

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JP2017518306A true JP2017518306A (ja) 2017-07-06
JP2017518306A5 JP2017518306A5 (cg-RX-API-DMAC7.html) 2018-07-12

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US (1) US10316054B2 (cg-RX-API-DMAC7.html)
EP (1) EP3149016A1 (cg-RX-API-DMAC7.html)
JP (1) JP2017518306A (cg-RX-API-DMAC7.html)
KR (1) KR20170012449A (cg-RX-API-DMAC7.html)
CN (1) CN106536535A (cg-RX-API-DMAC7.html)
AU (1) AU2015270130A1 (cg-RX-API-DMAC7.html)
CA (1) CA2950727A1 (cg-RX-API-DMAC7.html)
MX (1) MX2016015997A (cg-RX-API-DMAC7.html)
RU (1) RU2016149764A (cg-RX-API-DMAC7.html)
WO (1) WO2015186068A1 (cg-RX-API-DMAC7.html)

Cited By (5)

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JP2021506898A (ja) * 2017-12-22 2021-02-22 エリシウム ヘルス，インコーポレーテッド ニコチンアミドリボシドクロリドの結晶形態
JP2022541058A (ja) * 2019-07-19 2022-09-21 バイオシント アクチェンゲゼルシャフト ニコチンアミドリボフラノシド塩の製造方法、ニコチンアミドリボフラノシド塩自体、およびその使用
JP2022542546A (ja) * 2020-06-19 2022-10-05 ボンタック バイオエンジニアリング（シェンゼン） カンパニー リミテッド ニコチンアミドを原料としてニコチンアミドモノヌクレオチドを調製する方法
JP2023510034A (ja) * 2020-04-03 2023-03-10 深▲せん▼市迪克曼科技開発有限公司 ニコチンアミドリボースの有機酸塩、その組成物及び製造方法
JP2024503442A (ja) * 2021-01-19 2024-01-25 バイオシント アクチェンゲゼルシャフト 塩メタセシスによるニコチンアミドリボフラノシド塩の製造方法、そのトシレート塩の結晶形態及びそのクロリド：ヨージド塩の共結晶化した形態

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US10611790B2 (en) 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
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GB2553001A (en) * 2016-08-19 2018-02-21 The Queen's Univ Of Belfast Lactone intermediates of nicotinamide riboside and nicotinate riboside
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NZ803738A (en) * 2016-11-11 2024-05-31 Chromadex Inc Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
BR112019010607B1 (pt) 2016-11-29 2023-10-31 University Of Iowa Research Foundation Uso de precursores de nad e composição compreendendo os referidos precursores
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
US20200121704A1 (en) * 2017-01-13 2020-04-23 The Regents Of The University Of Colorado, A Body Corporate Methods for treating hypertension and arterial stiffness
US11129843B2 (en) 2017-04-24 2021-09-28 Elysium Health, Inc. Treating and preventing kidney damage
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WO2018236747A1 (en) * 2017-06-21 2018-12-27 Yale University Compounds and compositions for extending lifespan of a subject
WO2019006262A1 (en) * 2017-06-30 2019-01-03 Elysium Health, Inc. METHODS OF SYNTHESIZING NICOTINAMIDE RIBOSIDE
KR101990681B1 (ko) * 2017-07-05 2019-06-18 가천대학교 산학협력단 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법
KR101982923B1 (ko) * 2017-07-05 2019-05-27 가천대학교 산학협력단 편두통 진단용 바이오마커 및 상기 바이오마커를 이용한 편두통 진단방법
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WO2019209840A1 (en) * 2018-04-23 2019-10-31 Elysium Health, Inc. Methods and compositions for treating rheumatoid arthritis
CN110452277A (zh) * 2018-05-07 2019-11-15 明特奇点医疗科技(成都)有限公司 一种烟酰胺核糖的制备方法
US11447514B2 (en) 2018-05-18 2022-09-20 Roche Diagnostics Operations, Inc. (Thio)nicotinamide ribofuranoside salts and compositions, methods of making, and uses thereof
US20210267251A1 (en) 2018-06-21 2021-09-02 Societe Des Produits Nestle S.A. Compositions and methods using a nicotinamide adenine dinucleotide (nad+) precursor and at least one ketone or ketone precursor
CN108774278A (zh) * 2018-09-10 2018-11-09 张洪喜 一种制备尼克酰胺核苷盐的方法
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
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CN111808156A (zh) * 2020-07-15 2020-10-23 许昌远志生物科技有限公司 一种β-烟酰胺核糖氯化物的晶型1A、晶型1B及其制备方法
WO2022047182A1 (en) * 2020-08-28 2022-03-03 University Of Washington High dose nicotinamide adenine dinucleotide (nad) precursor regimens for reduction of inflammation in human patients with preexisting inflammation
CN112028954B (zh) * 2020-09-14 2022-04-29 浩宇康宁健康科技（湖北）有限公司 烟酰胺核糖的制备方法
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CN114577935B (zh) * 2022-03-03 2024-07-23 中科谱研（北京）科技有限公司 一种胶囊中烟酰胺核糖氯化物的分离检测方法
JP2025509064A (ja) * 2022-03-15 2025-04-11 クロマデックス，インコーポレイテッド 結晶性のベータニコチンアミドリボシドトリアセタートクロリドを生成する方法
CN114933621A (zh) * 2022-04-13 2022-08-23 深圳市迪克曼生物科技有限公司 烟酰胺核糖的有机酸盐及其结晶形态、制备方法与用途
CN115287278B (zh) * 2022-06-17 2023-11-10 武汉真福医药股份有限公司 一种枯草芽孢杆菌纤溶酶及其制备方法和抗氧化溶血栓组合物
CN120603587A (zh) 2023-02-01 2025-09-05 博迪贺康(绍兴)生物技术有限公司 一种化合物及其应用
CN116655528B (zh) * 2023-04-28 2025-12-02 宁波百思佳医药科技有限公司 一种氯化1-甲基烟酰铵的制备方法

Citations (2)

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