JP2017517257A5 - - Google Patents
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- Publication number
- JP2017517257A5 JP2017517257A5 JP2016568644A JP2016568644A JP2017517257A5 JP 2017517257 A5 JP2017517257 A5 JP 2017517257A5 JP 2016568644 A JP2016568644 A JP 2016568644A JP 2016568644 A JP2016568644 A JP 2016568644A JP 2017517257 A5 JP2017517257 A5 JP 2017517257A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- dna sequence
- negative strain
- effector protein
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 42
- 239000012636 effector Substances 0.000 claims 21
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 18
- 230000001580 bacterial effect Effects 0.000 claims 12
- 230000025915 regulation of apoptotic process Effects 0.000 claims 6
- 241000607142 Salmonella Species 0.000 claims 5
- 241000607734 Yersinia <bacteria> Species 0.000 claims 5
- 230000006907 apoptotic process Effects 0.000 claims 5
- 210000003527 eukaryotic cell Anatomy 0.000 claims 4
- 210000004898 n-terminal fragment Anatomy 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 241001138501 Salmonella enterica Species 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000007547 defect Effects 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 claims 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 102000011727 Caspases Human genes 0.000 claims 1
- 108010076667 Caspases Proteins 0.000 claims 1
- 102000009058 Death Domain Receptors Human genes 0.000 claims 1
- 108010049207 Death Domain Receptors Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 1
- 102000001702 Intracellular Signaling Peptides and Proteins Human genes 0.000 claims 1
- 108010068964 Intracellular Signaling Peptides and Proteins Proteins 0.000 claims 1
- 102000035195 Peptidases Human genes 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 101000677856 Stenotrophomonas maltophilia (strain K279a) Actin-binding protein Smlt3054 Proteins 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- 241000607447 Yersinia enterocolitica Species 0.000 claims 1
- 230000009949 anti-apoptotic pathway Effects 0.000 claims 1
- 230000022131 cell cycle Effects 0.000 claims 1
- 230000004640 cellular pathway Effects 0.000 claims 1
- 230000005754 cellular signaling Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002744 extracellular matrix Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000013537 high throughput screening Methods 0.000 claims 1
- 230000007757 pro-survival signaling Effects 0.000 claims 1
- 102000034285 signal transducing proteins Human genes 0.000 claims 1
- 108091006024 signal transducing proteins Proteins 0.000 claims 1
- 102000030938 small GTPase Human genes 0.000 claims 1
- 108060007624 small GTPase Proteins 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 230000004654 survival pathway Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14169335.8 | 2014-05-21 | ||
| EP14169335 | 2014-05-21 | ||
| PCT/EP2015/061086 WO2015177197A1 (en) | 2014-05-21 | 2015-05-20 | Bacteria-based protein delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121375A Division JP2020182478A (ja) | 2014-05-21 | 2020-07-15 | 細菌に基づくタンパク質送達 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017517257A JP2017517257A (ja) | 2017-06-29 |
| JP2017517257A5 true JP2017517257A5 (enExample) | 2018-06-28 |
| JP6797025B2 JP6797025B2 (ja) | 2020-12-09 |
Family
ID=50771120
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568644A Active JP6797025B2 (ja) | 2014-05-21 | 2015-05-20 | 細菌に基づくタンパク質送達 |
| JP2020121375A Withdrawn JP2020182478A (ja) | 2014-05-21 | 2020-07-15 | 細菌に基づくタンパク質送達 |
| JP2022069709A Active JP7509821B2 (ja) | 2014-05-21 | 2022-04-20 | 細菌に基づくタンパク質送達 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020121375A Withdrawn JP2020182478A (ja) | 2014-05-21 | 2020-07-15 | 細菌に基づくタンパク質送達 |
| JP2022069709A Active JP7509821B2 (ja) | 2014-05-21 | 2022-04-20 | 細菌に基づくタンパク質送達 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10889823B2 (enExample) |
| EP (2) | EP3660034A1 (enExample) |
| JP (3) | JP6797025B2 (enExample) |
| KR (2) | KR102648293B1 (enExample) |
| CN (2) | CN107001431B (enExample) |
| AU (1) | AU2015261905B2 (enExample) |
| BR (1) | BR112016027196B1 (enExample) |
| CA (1) | CA2948570C (enExample) |
| CY (1) | CY1122701T1 (enExample) |
| DK (1) | DK3145946T3 (enExample) |
| EA (1) | EA201692025A1 (enExample) |
| ES (1) | ES2754508T3 (enExample) |
| HR (1) | HRP20192050T1 (enExample) |
| HU (1) | HUE046025T2 (enExample) |
| IL (2) | IL248827B (enExample) |
| LT (1) | LT3145946T (enExample) |
| PL (1) | PL3145946T3 (enExample) |
| PT (1) | PT3145946T (enExample) |
| RS (1) | RS59583B1 (enExample) |
| SG (1) | SG11201609629YA (enExample) |
| SI (1) | SI3145946T1 (enExample) |
| SM (1) | SMT201900626T1 (enExample) |
| WO (1) | WO2015177197A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015177197A1 (en) | 2014-05-21 | 2015-11-26 | Universitaet Basel | Bacteria-based protein delivery |
| EA201890868A1 (ru) | 2015-11-19 | 2018-12-28 | Университет Базель | Бактерии с ослабленной вирулентностью для лечения злокачественных солидных опухолей |
| US11365225B2 (en) * | 2015-11-19 | 2022-06-21 | President And Fellows Of Harvard College | Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria |
| KR102689434B1 (ko) * | 2015-11-19 | 2024-07-29 | 우니페르시테트 바젤 | 박테리아-기반의 단백질 전달 |
| US12351805B2 (en) | 2015-11-19 | 2025-07-08 | Northeastern University | Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria |
| HRP20211516T1 (hr) * | 2016-12-20 | 2021-12-24 | Universität Basel | Isporuka proteina na bazi bakterija oslabljene virulencije |
| WO2018183850A2 (en) * | 2017-03-31 | 2018-10-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods, systems, and compositions for inhibiting virulance of a/e family pathogens |
| CN107858367A (zh) * | 2017-12-05 | 2018-03-30 | 复旦大学附属肿瘤医院 | 一种利用细菌靶向投递治疗性蛋白的系统及其应用 |
| EP3962512A4 (en) * | 2019-05-01 | 2023-01-18 | Innate Biologics LLC | IMMUNOMODULATORY COMPOSITIONS AND METHODS |
| WO2021076897A1 (en) * | 2019-10-18 | 2021-04-22 | University Of Virginia Patent Foundation | Compositions and methods for producing enhanced immune responses and rapid antibody production |
| CN111848803B (zh) * | 2020-07-21 | 2022-04-08 | 珠海中科先进技术研究院有限公司 | 一种具有突出酸碱稳定性的磷脂酰肌醇蛋白聚糖3的纳米抗体及其制备方法 |
| WO2022087856A1 (zh) * | 2020-10-26 | 2022-05-05 | 南京吉芮康生物科技研究院有限公司 | 一种减毒沙门氏菌分泌表达rbd结构域蛋白的新型冠状病毒疫苗抗原递呈系统及其应用 |
| CN114712496B (zh) * | 2022-04-29 | 2023-10-13 | 中山大学·深圳 | 一种展示新抗原的细菌衍生外膜囊泡疫苗及制备方法和在制备癌症免疫治疗试剂盒中的应用 |
| CN115896314A (zh) * | 2022-07-14 | 2023-04-04 | 四川大学 | 一种基于lf-rpa的猕猴桃细菌性溃疡病菌的无设备、可视化检测方法 |
| CN117511912B (zh) * | 2023-12-22 | 2024-03-29 | 辉大(上海)生物科技有限公司 | IscB多肽、包含其的系统及其用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965381A (en) * | 1998-03-06 | 1999-10-12 | Ludwig Institute For Cancer Research | Delivery of proteins into eukaryotic cells with recombinant yersinia |
| WO2000002996A2 (en) * | 1998-07-10 | 2000-01-20 | Cornell Research Foundation, Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
| CA2424004A1 (en) | 2000-09-26 | 2002-04-04 | Roger William Hospital | Recombinant bcg vaccines for the prevention and treatment of cancer |
| AU2002312778A1 (en) | 2001-03-26 | 2002-10-08 | Universite Catholique De Louvain | Type iii bacterial strains for use in medicine |
| FR2862312B1 (fr) * | 2003-11-13 | 2006-02-17 | Univ Grenoble 1 | Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas |
| JP2009501357A (ja) | 2005-07-15 | 2009-01-15 | レアード テクノロジーズ マップ カンパニー リミテッド | 小型カメラ用開閉装置 |
| EP1943344A2 (en) | 2005-10-04 | 2008-07-16 | The Ludwig Institute for Cancer Research | Methods for stimulating an immune response using bacterial antigen delivery system |
| WO2008019183A2 (en) * | 2006-05-18 | 2008-02-14 | The Regents Of The University Of California | Biopolymer and protein production using type iii secretion systems of gram negative bacteria |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| EP1921149A1 (en) * | 2006-11-13 | 2008-05-14 | AEterna Zentaris GmbH | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| WO2009115531A2 (en) * | 2008-03-17 | 2009-09-24 | Universitätsklinikum Münster | Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions |
| WO2010135563A1 (en) * | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| CA2925417C (en) | 2013-09-24 | 2023-10-24 | Fahar Merchant | Interleukin-4 receptor-binding fusion proteins and uses thereof |
| US10143743B2 (en) | 2013-11-18 | 2018-12-04 | Yale University | Non-replicating bacterial nanoparticle delivery system and methods of use |
| WO2015177197A1 (en) | 2014-05-21 | 2015-11-26 | Universitaet Basel | Bacteria-based protein delivery |
| KR102689434B1 (ko) * | 2015-11-19 | 2024-07-29 | 우니페르시테트 바젤 | 박테리아-기반의 단백질 전달 |
| EA201890868A1 (ru) | 2015-11-19 | 2018-12-28 | Университет Базель | Бактерии с ослабленной вирулентностью для лечения злокачественных солидных опухолей |
| HRP20211516T1 (hr) | 2016-12-20 | 2021-12-24 | Universität Basel | Isporuka proteina na bazi bakterija oslabljene virulencije |
-
2015
- 2015-05-20 WO PCT/EP2015/061086 patent/WO2015177197A1/en not_active Ceased
- 2015-05-20 US US15/311,424 patent/US10889823B2/en active Active
- 2015-05-20 PL PL15725282T patent/PL3145946T3/pl unknown
- 2015-05-20 RS RS20191450A patent/RS59583B1/sr unknown
- 2015-05-20 ES ES15725282T patent/ES2754508T3/es active Active
- 2015-05-20 JP JP2016568644A patent/JP6797025B2/ja active Active
- 2015-05-20 DK DK15725282T patent/DK3145946T3/da active
- 2015-05-20 HU HUE15725282A patent/HUE046025T2/hu unknown
- 2015-05-20 CA CA2948570A patent/CA2948570C/en active Active
- 2015-05-20 CN CN201580040391.2A patent/CN107001431B/zh active Active
- 2015-05-20 EA EA201692025A patent/EA201692025A1/ru unknown
- 2015-05-20 SG SG11201609629YA patent/SG11201609629YA/en unknown
- 2015-05-20 AU AU2015261905A patent/AU2015261905B2/en active Active
- 2015-05-20 EP EP19191383.9A patent/EP3660034A1/en active Pending
- 2015-05-20 BR BR112016027196-3A patent/BR112016027196B1/pt active IP Right Grant
- 2015-05-20 KR KR1020227030220A patent/KR102648293B1/ko active Active
- 2015-05-20 HR HRP20192050TT patent/HRP20192050T1/hr unknown
- 2015-05-20 SI SI201530993T patent/SI3145946T1/sl unknown
- 2015-05-20 LT LT15725282T patent/LT3145946T/lt unknown
- 2015-05-20 SM SM20190626T patent/SMT201900626T1/it unknown
- 2015-05-20 EP EP15725282.6A patent/EP3145946B1/en active Active
- 2015-05-20 PT PT157252826T patent/PT3145946T/pt unknown
- 2015-05-20 CN CN202211325325.8A patent/CN115960919A/zh active Pending
- 2015-05-20 KR KR1020167035405A patent/KR102440293B1/ko active Active
-
2016
- 2016-11-08 IL IL248827A patent/IL248827B/en unknown
-
2019
- 2019-11-01 CY CY20191101138T patent/CY1122701T1/el unknown
-
2020
- 2020-07-15 JP JP2020121375A patent/JP2020182478A/ja not_active Withdrawn
- 2020-12-03 US US17/111,332 patent/US12091670B2/en active Active
-
2021
- 2021-05-19 IL IL283280A patent/IL283280B2/en unknown
-
2022
- 2022-04-20 JP JP2022069709A patent/JP7509821B2/ja active Active
-
2024
- 2024-08-15 US US18/806,599 patent/US20240401065A1/en active Pending
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