JP2015523066A5 - - Google Patents

Info

Publication number

JP2015523066A5

JP2015523066A5 JP2015515191A JP2015515191A JP2015523066A5 JP 2015523066 A5 JP2015523066 A5 JP 2015523066A5 JP 2015515191 A JP2015515191 A JP 2015515191A JP 2015515191 A JP2015515191 A JP 2015515191A JP 2015523066 A5 JP2015523066 A5 JP 2015523066A5

Authority

JP

Japan

Prior art keywords

nucleic acid

acid sequence

cleavage site

flgm

peptide

Prior art date

2013-05-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 22
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
• 238000003776 cleavage reaction Methods 0.000 claims 16
• 150000007523 nucleic acids Chemical group 0.000 claims 16
• 230000007017 scission Effects 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 238000000746 purification Methods 0.000 claims 11
• 108700029229 Transcriptional Regulatory Elements Proteins 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 101000844746 Drosophila melanogaster Drosomycin Proteins 0.000 claims 4
• 239000003053 toxin Substances 0.000 claims 4
• 231100000765 toxin Toxicity 0.000 claims 4
• 102100029727 Enteropeptidase Human genes 0.000 claims 3
• 108010013369 Enteropeptidase Proteins 0.000 claims 3
• 108010040721 Flagellin Proteins 0.000 claims 2
• 102000005720 Glutathione transferase Human genes 0.000 claims 2
• 108010070675 Glutathione transferase Proteins 0.000 claims 2
• 101710175625 Maltose/maltodextrin-binding periplasmic protein Proteins 0.000 claims 2
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims 2
• 241000723792 Tobacco etch virus Species 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 229920002704 polyhistidine Polymers 0.000 claims 2
• -1 srgD Proteins 0.000 claims 2
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
• 101100281124 Aquifex aeolicus (strain VF5) flaA gene Proteins 0.000 claims 1
• 101100173925 Caulobacter vibrioides (strain ATCC 19089 / CB15) fljL gene Proteins 0.000 claims 1
• 101100500579 Citrobacter freundii ecnR gene Proteins 0.000 claims 1
• 101100108073 Drosophila melanogaster Actn gene Proteins 0.000 claims 1
• 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
• 108010085220 Multiprotein Complexes Proteins 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
• 108010076818 TEV protease Proteins 0.000 claims 1
• 239000004098 Tetracycline Substances 0.000 claims 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 101150074451 clpP gene Proteins 0.000 claims 1
• 101150043719 clpP1 gene Proteins 0.000 claims 1
• 101150102296 clpP2 gene Proteins 0.000 claims 1
• 101150096566 clpX gene Proteins 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 229960003722 doxycycline Drugs 0.000 claims 1
• 101150035430 fimZ gene Proteins 0.000 claims 1
• 210000003495 flagella Anatomy 0.000 claims 1
• 101150010879 flgK gene Proteins 0.000 claims 1
• 101150064216 flgL gene Proteins 0.000 claims 1
• 101150017109 fliA gene Proteins 0.000 claims 1
• 101150038062 fliC gene Proteins 0.000 claims 1
• 101150094936 fliD gene Proteins 0.000 claims 1
• 101150104647 fljB gene Proteins 0.000 claims 1
• 102000034356 gene-regulatory proteins Human genes 0.000 claims 1
• 108091006104 gene-regulatory proteins Proteins 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 101150061503 hdfR gene Proteins 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 101150016443 lrhA gene Proteins 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000002609 medium Substances 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 101150091444 ompR gene Proteins 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 101150015201 rbsR gene Proteins 0.000 claims 1
• 230000003248 secreting effect Effects 0.000 claims 1
• 230000028327 secretion Effects 0.000 claims 1
• 229960002180 tetracycline Drugs 0.000 claims 1
• 229930101283 tetracycline Natural products 0.000 claims 1
• 235000019364 tetracycline Nutrition 0.000 claims 1
• 150000003522 tetracyclines Chemical class 0.000 claims 1
• 238000013518 transcription Methods 0.000 claims 1
• 230000035897 transcription Effects 0.000 claims 1
• 101150075472 ycf27 gene Proteins 0.000 claims 1
• 101150032824 ydiV gene Proteins 0.000 claims 1