AU2015261905B2 - Bacteria-based protein delivery - Google Patents
Bacteria-based protein delivery Download PDFInfo
- Publication number
- AU2015261905B2 AU2015261905B2 AU2015261905A AU2015261905A AU2015261905B2 AU 2015261905 B2 AU2015261905 B2 AU 2015261905B2 AU 2015261905 A AU2015261905 A AU 2015261905A AU 2015261905 A AU2015261905 A AU 2015261905A AU 2015261905 B2 AU2015261905 B2 AU 2015261905B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- G01N2333/245—Escherichia (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- G01N2333/255—Salmonella (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14169335.8 | 2014-05-21 | ||
| EP14169335 | 2014-05-21 | ||
| PCT/EP2015/061086 WO2015177197A1 (en) | 2014-05-21 | 2015-05-20 | Bacteria-based protein delivery |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015261905A1 AU2015261905A1 (en) | 2016-12-01 |
| AU2015261905B2 true AU2015261905B2 (en) | 2020-07-09 |
Family
ID=50771120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015261905A Active AU2015261905B2 (en) | 2014-05-21 | 2015-05-20 | Bacteria-based protein delivery |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US10889823B2 (enExample) |
| EP (2) | EP3660034A1 (enExample) |
| JP (3) | JP6797025B2 (enExample) |
| KR (2) | KR102648293B1 (enExample) |
| CN (2) | CN115960919A (enExample) |
| AU (1) | AU2015261905B2 (enExample) |
| BR (1) | BR112016027196B1 (enExample) |
| CA (1) | CA2948570C (enExample) |
| CY (1) | CY1122701T1 (enExample) |
| DK (1) | DK3145946T3 (enExample) |
| EA (1) | EA201692025A1 (enExample) |
| ES (1) | ES2754508T3 (enExample) |
| HR (1) | HRP20192050T1 (enExample) |
| HU (1) | HUE046025T2 (enExample) |
| IL (2) | IL248827B (enExample) |
| LT (1) | LT3145946T (enExample) |
| PL (1) | PL3145946T3 (enExample) |
| PT (1) | PT3145946T (enExample) |
| RS (1) | RS59583B1 (enExample) |
| SG (1) | SG11201609629YA (enExample) |
| SI (1) | SI3145946T1 (enExample) |
| SM (1) | SMT201900626T1 (enExample) |
| WO (1) | WO2015177197A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3660034A1 (en) | 2014-05-21 | 2020-06-03 | Universität Basel | Bacteria-based protein delivey |
| AU2016358257B2 (en) | 2015-11-19 | 2023-08-17 | Universitat Basel | Virulence attenuated bacteria for treatment of malignant solid tumors |
| US12351805B2 (en) | 2015-11-19 | 2025-07-08 | Northeastern University | Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria |
| US11365225B2 (en) * | 2015-11-19 | 2022-06-21 | President And Fellows Of Harvard College | Method of making recombinant silk and silk-amyloid hybrid proteins using bacteria |
| WO2017085235A1 (en) | 2015-11-19 | 2017-05-26 | Universität Basel | Bacteria-based protein delivery |
| MX2019007264A (es) | 2016-12-20 | 2019-11-18 | Univ Basel | Suministro de proteinas basado en bacterias con virulencia atenuada. |
| US11484603B2 (en) | 2017-03-31 | 2022-11-01 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods, systems, and compositions for inhibiting virulence of A/E family pathogens |
| CN107858367A (zh) * | 2017-12-05 | 2018-03-30 | 复旦大学附属肿瘤医院 | 一种利用细菌靶向投递治疗性蛋白的系统及其应用 |
| CN114401730A (zh) * | 2019-05-01 | 2022-04-26 | 因内特生物制品有限责任公司 | 免疫调节组合物和方法 |
| WO2021076897A1 (en) * | 2019-10-18 | 2021-04-22 | University Of Virginia Patent Foundation | Compositions and methods for producing enhanced immune responses and rapid antibody production |
| CN111848803B (zh) * | 2020-07-21 | 2022-04-08 | 珠海中科先进技术研究院有限公司 | 一种具有突出酸碱稳定性的磷脂酰肌醇蛋白聚糖3的纳米抗体及其制备方法 |
| WO2022087856A1 (zh) * | 2020-10-26 | 2022-05-05 | 南京吉芮康生物科技研究院有限公司 | 一种减毒沙门氏菌分泌表达rbd结构域蛋白的新型冠状病毒疫苗抗原递呈系统及其应用 |
| CN114712496B (zh) * | 2022-04-29 | 2023-10-13 | 中山大学·深圳 | 一种展示新抗原的细菌衍生外膜囊泡疫苗及制备方法和在制备癌症免疫治疗试剂盒中的应用 |
| CN115896314A (zh) * | 2022-07-14 | 2023-04-04 | 四川大学 | 一种基于lf-rpa的猕猴桃细菌性溃疡病菌的无设备、可视化检测方法 |
| CN117511912B (zh) * | 2023-12-22 | 2024-03-29 | 辉大(上海)生物科技有限公司 | IscB多肽、包含其的系统及其用途 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000002996A2 (en) * | 1998-07-10 | 2000-01-20 | Cornell Research Foundation, Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
| WO2008019183A2 (en) * | 2006-05-18 | 2008-02-14 | The Regents Of The University Of California | Biopolymer and protein production using type iii secretion systems of gram negative bacteria |
| US20080187520A1 (en) * | 2003-11-13 | 2008-08-07 | Universite Joseph Fourier | Tool for the transfer and production of proteins using the pseudomonas type III secretion system |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965381A (en) * | 1998-03-06 | 1999-10-12 | Ludwig Institute For Cancer Research | Delivery of proteins into eukaryotic cells with recombinant yersinia |
| CA2424004A1 (en) | 2000-09-26 | 2002-04-04 | Roger William Hospital | Recombinant bcg vaccines for the prevention and treatment of cancer |
| US20040147719A1 (en) * | 2001-03-26 | 2004-07-29 | Guy Cornelis | Type III bacterial strains for use in medicine |
| JP2009501357A (ja) | 2005-07-15 | 2009-01-15 | レアード テクノロジーズ マップ カンパニー リミテッド | 小型カメラ用開閉装置 |
| US8357373B2 (en) | 2005-10-04 | 2013-01-22 | Ludwig Institute For Cancer Research | Methods for stimulating an immune response using bacterial antigen delivery system |
| TW200819540A (en) | 2006-07-11 | 2008-05-01 | Genelux Corp | Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders |
| EP1921149A1 (en) * | 2006-11-13 | 2008-05-14 | AEterna Zentaris GmbH | Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof |
| WO2009115531A2 (en) * | 2008-03-17 | 2009-09-24 | Universitätsklinikum Münster | Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions |
| WO2010135563A1 (en) * | 2009-05-22 | 2010-11-25 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium and methods of antigen and nucleic acid delivery |
| CN105722982A (zh) | 2013-09-24 | 2016-06-29 | 梅迪塞纳医疗股份有限公司 | 白介素-4受体结合融合蛋白及其应用 |
| US10143743B2 (en) | 2013-11-18 | 2018-12-04 | Yale University | Non-replicating bacterial nanoparticle delivery system and methods of use |
| EP3660034A1 (en) | 2014-05-21 | 2020-06-03 | Universität Basel | Bacteria-based protein delivey |
| WO2017085235A1 (en) | 2015-11-19 | 2017-05-26 | Universität Basel | Bacteria-based protein delivery |
| AU2016358257B2 (en) | 2015-11-19 | 2023-08-17 | Universitat Basel | Virulence attenuated bacteria for treatment of malignant solid tumors |
| MX2019007264A (es) | 2016-12-20 | 2019-11-18 | Univ Basel | Suministro de proteinas basado en bacterias con virulencia atenuada. |
-
2015
- 2015-05-20 EP EP19191383.9A patent/EP3660034A1/en active Pending
- 2015-05-20 WO PCT/EP2015/061086 patent/WO2015177197A1/en not_active Ceased
- 2015-05-20 CN CN202211325325.8A patent/CN115960919A/zh active Pending
- 2015-05-20 DK DK15725282T patent/DK3145946T3/da active
- 2015-05-20 SG SG11201609629YA patent/SG11201609629YA/en unknown
- 2015-05-20 HU HUE15725282A patent/HUE046025T2/hu unknown
- 2015-05-20 SI SI201530993T patent/SI3145946T1/sl unknown
- 2015-05-20 SM SM20190626T patent/SMT201900626T1/it unknown
- 2015-05-20 LT LT15725282T patent/LT3145946T/lt unknown
- 2015-05-20 KR KR1020227030220A patent/KR102648293B1/ko active Active
- 2015-05-20 ES ES15725282T patent/ES2754508T3/es active Active
- 2015-05-20 RS RS20191450A patent/RS59583B1/sr unknown
- 2015-05-20 CA CA2948570A patent/CA2948570C/en active Active
- 2015-05-20 EA EA201692025A patent/EA201692025A1/ru unknown
- 2015-05-20 BR BR112016027196-3A patent/BR112016027196B1/pt active IP Right Grant
- 2015-05-20 PT PT157252826T patent/PT3145946T/pt unknown
- 2015-05-20 HR HRP20192050TT patent/HRP20192050T1/hr unknown
- 2015-05-20 CN CN201580040391.2A patent/CN107001431B/zh active Active
- 2015-05-20 JP JP2016568644A patent/JP6797025B2/ja active Active
- 2015-05-20 EP EP15725282.6A patent/EP3145946B1/en active Active
- 2015-05-20 PL PL15725282T patent/PL3145946T3/pl unknown
- 2015-05-20 AU AU2015261905A patent/AU2015261905B2/en active Active
- 2015-05-20 KR KR1020167035405A patent/KR102440293B1/ko active Active
- 2015-05-20 US US15/311,424 patent/US10889823B2/en active Active
-
2016
- 2016-11-08 IL IL248827A patent/IL248827B/en unknown
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2019
- 2019-11-01 CY CY20191101138T patent/CY1122701T1/el unknown
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2020
- 2020-07-15 JP JP2020121375A patent/JP2020182478A/ja not_active Withdrawn
- 2020-12-03 US US17/111,332 patent/US12091670B2/en active Active
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2021
- 2021-05-19 IL IL283280A patent/IL283280B2/en unknown
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2022
- 2022-04-20 JP JP2022069709A patent/JP7509821B2/ja active Active
-
2024
- 2024-08-15 US US18/806,599 patent/US20240401065A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000002996A2 (en) * | 1998-07-10 | 2000-01-20 | Cornell Research Foundation, Inc. | Recombinant constructs and systems for secretion of proteins via type iii secretion systems |
| US20080187520A1 (en) * | 2003-11-13 | 2008-08-07 | Universite Joseph Fourier | Tool for the transfer and production of proteins using the pseudomonas type III secretion system |
| WO2008019183A2 (en) * | 2006-05-18 | 2008-02-14 | The Regents Of The University Of California | Biopolymer and protein production using type iii secretion systems of gram negative bacteria |
Also Published As
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| HK1236208A1 (en) | Bacteria-based protein delivery | |
| HK1256138B (en) | Bacteria-based protein delivery | |
| EA041646B1 (ru) | Доставка белков, осуществляемая на основе бактерий |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |