|
US3539465A
(en)
|
1968-10-08 |
1970-11-10 |
Ncr Co |
Encapsulation of hydrophilic liquid-in-oil emulsions
|
|
US5993434A
(en)
*
|
1993-04-01 |
1999-11-30 |
Genetronics, Inc. |
Method of treatment using electroporation mediated delivery of drugs and genes
|
|
US5843780A
(en)
|
1995-01-20 |
1998-12-01 |
Wisconsin Alumni Research Foundation |
Primate embryonic stem cells
|
|
US5711964A
(en)
|
1995-06-07 |
1998-01-27 |
United States Of America |
Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D
|
|
US6602693B1
(en)
|
1996-07-03 |
2003-08-05 |
Clear Solutions Biotech, Inc. |
Gene encoding hyaluronan synthase
|
|
EP0955999B1
(en)
|
1996-08-19 |
2001-12-05 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
Novel liposome complexes for increased systemic delivery
|
|
US6770291B2
(en)
|
1996-08-30 |
2004-08-03 |
The United States Of America As Represented By The Department Of Health And Human Services |
Liposome complexes for increased systemic delivery
|
|
TW520297B
(en)
|
1996-10-11 |
2003-02-11 |
Sequus Pharm Inc |
Fusogenic liposome composition and method
|
|
JP2001508302A
(ja)
|
1997-01-10 |
2001-06-26 |
ライフ テクノロジーズ,インコーポレイテッド |
胚性幹細胞血清置換
|
|
US6316260B1
(en)
|
1997-08-22 |
2001-11-13 |
Bernina Biosystems Gmbh |
Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraether lipid derivatives, and use thereof
|
|
EP1021549A2
(en)
|
1997-09-19 |
2000-07-26 |
Sequitur, Inc. |
SENSE mRNA THERAPY
|
|
US7390780B2
(en)
|
1999-04-23 |
2008-06-24 |
Alza Corporation |
Gene delivery mediated by liposome-DNA complex with cleavable peg surface modification
|
|
WO2000074763A2
(en)
|
1999-06-04 |
2000-12-14 |
Georgia Tech Research Corporation |
Devices and methods for enhanced microneedle penetration of biological barriers
|
|
US20110171185A1
(en)
|
1999-06-30 |
2011-07-14 |
Klimanskaya Irina V |
Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof
|
|
US20020054895A1
(en)
|
1999-07-23 |
2002-05-09 |
Alwyn Company, Inc. |
Allantoin-containing skin cream
|
|
US20020064876A1
(en)
*
|
1999-12-28 |
2002-05-30 |
Kyonggeun Yoon |
Novel gene therapy methods for the treatment of skin disorders
|
|
US6595947B1
(en)
|
2000-05-22 |
2003-07-22 |
Becton, Dickinson And Company |
Topical delivery of vaccines
|
|
EP2292632A3
(en)
|
2000-09-26 |
2012-07-25 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
|
|
US7189759B2
(en)
|
2001-05-23 |
2007-03-13 |
Medicis Pharmaceutical Corporation |
Compositions for the treatment of pigmentation disorders and methods for their manufacture
|
|
WO2003018767A2
(en)
|
2001-08-27 |
2003-03-06 |
Advanced Cell Technology, Inc. |
Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
|
|
WO2003027277A1
(en)
|
2001-09-21 |
2003-04-03 |
Japan Science And Technology Corporation |
Method of screening reporgramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs
|
|
US20050053588A1
(en)
|
2001-10-18 |
2005-03-10 |
Li Yin |
Conversion of liver stem and progenitor cells to pancreatic functional cells
|
|
US7276489B2
(en)
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
GB0202149D0
(en)
|
2002-01-30 |
2002-03-20 |
Univ Edinburgh |
Pluripotency determining factors and uses thereof
|
|
US20030186249A1
(en)
|
2002-04-01 |
2003-10-02 |
Zairen Sun |
Human TARPP genes and polypeptides
|
|
JP3785508B2
(ja)
|
2002-04-15 |
2006-06-14 |
学校法人慶應義塾 |
遺伝子治療における免疫応答を解析できる実験モデルマウス
|
|
US7737182B2
(en)
|
2002-08-09 |
2010-06-15 |
Taisho Pharmaceutical Co., Ltd. |
Pharmaceuticals for xerosis
|
|
JP4579911B2
(ja)
|
2003-06-03 |
2010-11-10 |
アイシス・ファーマシューティカルズ・インコーポレイテッド |
スルビビン発現の調節
|
|
JP2005046073A
(ja)
*
|
2003-07-29 |
2005-02-24 |
National Institute Of Advanced Industrial & Technology |
修飾核酸を用いるrna転写および/または増幅方法
|
|
US7682828B2
(en)
|
2003-11-26 |
2010-03-23 |
Whitehead Institute For Biomedical Research |
Methods for reprogramming somatic cells
|
|
BRPI0514778B1
(pt)
|
2004-09-08 |
2018-07-10 |
Wisconsin Alumni Research Foundation |
Meio para cultivar células tronco embrionárias
|
|
BRPI0514641A
(pt)
|
2004-09-08 |
2008-06-17 |
Wisconsin Alumni Res Found |
cultivação das células tronco embriÈnica humana
|
|
EP1913149A4
(en)
|
2005-07-26 |
2009-08-05 |
Sangamo Biosciences Inc |
TARGETED INTEGRATION AND EXPRESSION OF EXOGENOUS NUCLEIC ACID SEQUENCES
|
|
US8323666B2
(en)
|
2005-08-01 |
2012-12-04 |
Allergan, Inc. |
Botulinum toxin compositions
|
|
PL2578685T3
(pl)
|
2005-08-23 |
2020-01-31 |
The Trustees Of The University Of Pennsylvania |
Rna zawierający zmodyfikowane nukleozydy i sposoby jego zastosowania
|
|
US9012219B2
(en)
|
2005-08-23 |
2015-04-21 |
The Trustees Of The University Of Pennsylvania |
RNA preparations comprising purified modified RNA for reprogramming cells
|
|
WO2007026353A2
(en)
|
2005-08-29 |
2007-03-08 |
Technion Research & Development Foundation Ltd. |
Media for culturing stem cells
|
|
US8278104B2
(en)
|
2005-12-13 |
2012-10-02 |
Kyoto University |
Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
|
|
EP2206724A1
(en)
|
2005-12-13 |
2010-07-14 |
Kyoto University |
Nuclear reprogramming factor
|
|
US8129187B2
(en)
|
2005-12-13 |
2012-03-06 |
Kyoto University |
Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
|
|
WO2007079886A1
(de)
|
2005-12-22 |
2007-07-19 |
Csl Behring Gmbh |
Oktanoatreduziertes human albumin
|
|
DE102006051516A1
(de)
|
2006-10-31 |
2008-05-08 |
Curevac Gmbh |
(Basen-)modifizierte RNA zur Expressionssteigerung eines Proteins
|
|
GB0623635D0
(en)
|
2006-11-27 |
2007-01-03 |
Stem Cell Sciences Uk Ltd |
Pluripotent cell growth media
|
|
WO2008073856A2
(en)
|
2006-12-08 |
2008-06-19 |
Massachusetts Institute Of Technology |
Delivery of nanoparticles and/or agents to cells
|
|
CN101200758A
(zh)
|
2006-12-15 |
2008-06-18 |
华中科技大学 |
一种检测col7a1基因突变的方法及其用途
|
|
US10829733B2
(en)
|
2007-01-04 |
2020-11-10 |
Biolamina Ab |
Composition and method for enabling proliferation of pluripotent human stem cells
|
|
WO2008097926A2
(en)
|
2007-02-02 |
2008-08-14 |
Yale University |
Transient transfection with rna
|
|
US9249423B2
(en)
|
2007-02-02 |
2016-02-02 |
Yale University |
Method of de-differentiating and re-differentiating somatic cells using RNA
|
|
DK3399025T3
(da)
|
2007-03-23 |
2025-06-16 |
Wisconsin Alumni Res Found |
Omprogrammering af somatiske celler
|
|
MX348010B
(es)
|
2007-04-07 |
2017-05-23 |
Whitehead Inst Biomedical Res |
Reprogramacion de celulas somaticas.
|
|
WO2009046739A1
(en)
*
|
2007-10-09 |
2009-04-16 |
Curevac Gmbh |
Composition for treating prostate cancer (pca)
|
|
KR101532442B1
(ko)
|
2007-12-10 |
2015-06-29 |
고쿠리츠 다이가쿠 호진 교토 다이가쿠 |
효율적인 핵 초기화 방법
|
|
EP2072618A1
(en)
|
2007-12-14 |
2009-06-24 |
Johannes Gutenberg-Universität Mainz |
Use of RNA for reprogramming somatic cells
|
|
JP5951254B2
(ja)
|
2008-03-17 |
2016-07-13 |
ザ スクリプス リサーチ インスティテュート |
人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法
|
|
US20110045001A1
(en)
|
2008-03-28 |
2011-02-24 |
Biontex Laboratories Gmbh |
Transfection results of non-viral gene delivery systems by influencing of the innate immune system
|
|
WO2009127230A1
(en)
|
2008-04-16 |
2009-10-22 |
Curevac Gmbh |
MODIFIED (m)RNA FOR SUPPRESSING OR AVOIDING AN IMMUNOSTIMULATORY RESPONSE AND IMMUNOSUPPRESSIVE COMPOSITION
|
|
ES2587395T3
(es)
|
2008-06-04 |
2016-10-24 |
Cellular Dynamics International, Inc. |
Procedimientos para la producción de células IPS usando un enfoque no vírico
|
|
WO2009147400A1
(en)
|
2008-06-05 |
2009-12-10 |
Iti Scotland Limited |
Stem cell culture media and methods
|
|
WO2010008486A2
(en)
|
2008-06-24 |
2010-01-21 |
Parkinsons Institute |
Pluripotent cell lines and methods of use thereof
|
|
US20100184033A1
(en)
|
2008-07-16 |
2010-07-22 |
West Michael D |
Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
|
|
EP2151248A1
(en)
|
2008-07-30 |
2010-02-10 |
Johann Bauer |
Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses
|
|
EP2326711A2
(en)
|
2008-08-20 |
2011-06-01 |
VIRxSYS Corporation |
Compositions and methods for generation of pluripotent stem cells
|
|
EP3450545B1
(en)
|
2008-10-24 |
2023-08-23 |
Wisconsin Alumni Research Foundation |
Pluripotent stem cells obtained by non-viral reprogramming
|
|
EP2881461A1
(en)
|
2008-11-21 |
2015-06-10 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Reprogramming cells toward a pluripotent state
|
|
US20110239315A1
(en)
|
2009-01-12 |
2011-09-29 |
Ulla Bonas |
Modular dna-binding domains and methods of use
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
US20100209404A1
(en)
|
2009-02-10 |
2010-08-19 |
University Of Dayton |
Enhanced method for producing stem-like cells from somatic cells
|
|
US10894944B2
(en)
|
2009-04-10 |
2021-01-19 |
Monash University |
Cell culture media
|
|
WO2010123501A1
(en)
|
2009-04-22 |
2010-10-28 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long rna molecules
|
|
ES2849181T3
(es)
|
2009-04-22 |
2021-08-16 |
Viacyte Inc |
Composiciones celulares derivadas de células reprogramadas desdiferenciadas
|
|
US10837020B2
(en)
|
2009-04-22 |
2020-11-17 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long RNA molecules
|
|
JP2012524777A
(ja)
*
|
2009-04-22 |
2012-10-18 |
マサチューセッツ インスティテュート オブ テクノロジー |
長いrna分子の反復送達を可能にする自然免疫抑制
|
|
EP2251437B1
(en)
|
2009-05-13 |
2013-12-04 |
Hannelore Breitenbach-Koller |
Method for identifying compounds that control the translational activity of ribosomal proteins in differential mRNA expression
|
|
US8496941B2
(en)
|
2009-06-03 |
2013-07-30 |
National Institute Of Advanced Industrial Science And Technology |
Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
|
|
WO2010148050A2
(en)
*
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
|
EA022786B1
(ru)
|
2009-07-31 |
2016-03-31 |
Этрис Гмбх |
Рнк с комбинацией из немодифицированных и модифицированных нуклеотидов для экспрессии белков
|
|
KR101775926B1
(ko)
|
2009-11-04 |
2017-09-07 |
셀룰러 다이내믹스 인터내셔널, 인코포레이티드 |
화학 물질을 이용한 에피솜 재프로그래밍
|
|
EP2499239A1
(en)
|
2009-11-11 |
2012-09-19 |
Sanford-Burnham Medical Research Institute |
METHOD FOR GENERATION AND REGULATION OF iPS CELLS AND COMPOSITIONS THEREOF
|
|
ES2769129T3
(es)
|
2009-12-07 |
2020-06-24 |
Univ Pennsylvania |
Preparaciones de ARN que comprenden ARN modificado purificado para reprogramar células
|
|
US20130189741A1
(en)
|
2009-12-07 |
2013-07-25 |
Cellscript, Inc. |
Compositions and methods for reprogramming mammalian cells
|
|
PT2816112T
(pt)
|
2009-12-10 |
2018-11-20 |
Univ Iowa State Res Found Inc |
Modificação do adn modificada pelo efector tal
|
|
US8557972B2
(en)
|
2009-12-21 |
2013-10-15 |
University Of Washington Through Its Center For Commercialization |
Compositions and methods for transfection of RNA and controlled stabilization of transfected RNA
|
|
WO2011094738A1
(en)
|
2010-02-01 |
2011-08-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enhanced efficiency of induced pluripotent stem cell generation
|
|
US20140194482A1
(en)
|
2010-02-02 |
2014-07-10 |
Scioderm, Inc. |
Compositions and methods of treatment of inflammatory skin conditions using allantoin
|
|
WO2011110886A1
(en)
|
2010-03-09 |
2011-09-15 |
Biolamina Ab |
Composition and method for enabling proliferation of pluripotent human stem cells
|
|
WO2011130624A2
(en)
|
2010-04-16 |
2011-10-20 |
Immune Disease Institute, Inc. |
Sustained polypeptide expression from synthetic, modified rnas and uses thereof
|
|
US9725695B2
(en)
|
2010-05-05 |
2017-08-08 |
The Regents Of The University Of California |
Stem cell defined media for xeno-free and feeder free conditions and uses thereof
|
|
US8048675B1
(en)
|
2010-05-12 |
2011-11-01 |
Ipierian, Inc. |
Integration-free human induced pluripotent stem cells from blood
|
|
EP2569424A1
(en)
|
2010-05-12 |
2013-03-20 |
Cellectis |
Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
|
|
AU2011256838B2
(en)
|
2010-05-17 |
2014-10-09 |
Sangamo Therapeutics, Inc. |
Novel DNA-binding proteins and uses thereof
|
|
EP2392208B1
(en)
|
2010-06-07 |
2016-05-04 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Fusion proteins comprising a DNA-binding domain of a Tal effector protein and a non-specific cleavage domain of a restriction nuclease and their use
|
|
CN108531444A
(zh)
|
2010-08-05 |
2018-09-14 |
威斯康星校友研究基金会 |
用于人多能细胞培养的简化基础培养基
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US9447408B2
(en)
|
2010-09-14 |
2016-09-20 |
Kyoto University |
Method of efficiently establishing induced pluripotent stem cells
|
|
EP2857499A1
(en)
|
2010-10-01 |
2015-04-08 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
EP2625278A1
(en)
|
2010-10-08 |
2013-08-14 |
Regents of the University of Minnesota |
A method to increase gene targeting frequency
|
|
WO2012060473A1
(en)
|
2010-11-04 |
2012-05-10 |
Kyoto University |
Method of efficiently establishing induced pluripotent stem cells
|
|
AU2012225497A1
(en)
|
2011-03-07 |
2013-10-24 |
Massachusetts Institute Of Technology |
Methods for transfecting cells with nucleic acids
|
|
WO2012131090A1
(en)
|
2011-03-31 |
2012-10-04 |
Galderma Research & Development |
Method for treatment of xeroderma pigmentosum
|
|
CA2831613A1
(en)
|
2011-03-31 |
2012-10-04 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
US10086043B2
(en)
|
2011-04-03 |
2018-10-02 |
The General Hospital Corporation |
Efficient protein expression in vivo using modified RNA (MOD-RNA)
|
|
WO2012174224A2
(en)
*
|
2011-06-17 |
2012-12-20 |
Calando Pharmaceuticals, Inc. |
Methods for administering nucleic acid-based therapeutics
|
|
WO2012176015A1
(en)
|
2011-06-24 |
2012-12-27 |
Leo Pharma A/S |
Methods for treating uv-damaged skin and scc tumors and for removing tattoos with topical ingenol mebutate
|
|
US9862926B2
(en)
|
2011-06-27 |
2018-01-09 |
Cellscript, Llc. |
Inhibition of innate immune response
|
|
WO2013009825A1
(en)
*
|
2011-07-11 |
2013-01-17 |
Cellular Dynamics International, Inc. |
Methods for cell reprogramming and genome engineering
|
|
CN103842517A
(zh)
|
2011-08-03 |
2014-06-04 |
莲花组织修复公司 |
胶原蛋白7及相关方法
|
|
PT3682905T
(pt)
|
2011-10-03 |
2022-04-07 |
Modernatx Inc |
Nucleósidos, nucleótidos e ácidos nucleicos modificados e respetivas utilizações
|
|
EP2766480B1
(en)
*
|
2011-10-11 |
2018-03-14 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Exon skipping therapy for dystrophic epidermolysis bullosa
|
|
JP2013086009A
(ja)
|
2011-10-17 |
2013-05-13 |
Yamamoto Co Ltd |
自動精米装置
|
|
EP3260140B1
(en)
|
2011-12-05 |
2021-02-03 |
Factor Bioscience Inc. |
Methods and products for transfecting cells
|
|
US8497124B2
(en)
|
2011-12-05 |
2013-07-30 |
Factor Bioscience Inc. |
Methods and products for reprogramming cells to a less differentiated state
|
|
ES2923757T3
(es)
|
2011-12-16 |
2022-09-30 |
Modernatx Inc |
Composiciones de ARNm modificado
|
|
AU2012358384A1
(en)
|
2011-12-21 |
2014-07-31 |
Moderna Therapeutics, Inc. |
Methods of increasing the viability or longevity of an organ or organ explant
|
|
DK3421601T3
(da)
|
2011-12-30 |
2020-02-24 |
Cellscript Llc |
Fremstilling og anvendelse af in-vitro-syntetiseret ssRNA til indføring i pattedyrceller med henblik på at inducere en biologisk eller biokemisk effekt
|
|
WO2013151664A1
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins
|
|
AU2013251649B2
(en)
|
2012-04-24 |
2019-04-04 |
Vcell Therapeutics, Inc. |
Generating pluripotent cells de novo
|
|
CN104520424B
(zh)
|
2012-05-13 |
2019-06-28 |
美国绿阳生物技术及医药公司 |
使用合成的信使rna无饲养细胞地衍生人类诱导性多能干细胞
|
|
US10119150B2
(en)
|
2012-05-13 |
2018-11-06 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Feeder-free Derivation of human-induced pluripotent stem cells with synthetic messenger RNA
|
|
US10155929B2
(en)
|
2012-05-13 |
2018-12-18 |
Allele Biotechnology & Pharmaceuticals, Inc. |
Feeder-free derivation of human-induced pluripotent stem cells with synthetic messenger RNA
|
|
WO2014015314A1
(en)
|
2012-07-19 |
2014-01-23 |
University Of Southern California |
Recombinant c7 and methods of use
|
|
KR101979746B1
(ko)
*
|
2012-09-13 |
2019-05-17 |
(주)아모레퍼시픽 |
전기 천공 장치
|
|
SG10201707569YA
(en)
*
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
US10525075B2
(en)
|
2013-02-22 |
2020-01-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compounds, compositions, methods, and kits relating to telomere extension
|
|
WO2014134412A1
(en)
*
|
2013-03-01 |
2014-09-04 |
Regents Of The University Of Minnesota |
Talen-based gene correction
|
|
US20160220613A1
(en)
*
|
2013-09-16 |
2016-08-04 |
Agency For Science, Technology And Research |
Method
|
|
KR102415811B1
(ko)
|
2014-01-31 |
2022-07-04 |
팩터 바이오사이언스 인크. |
핵산 제조 및 송달을 위한 방법 및 산물
|