JP2017510257A5 - - Google Patents
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- JP2017510257A5 JP2017510257A5 JP2016554603A JP2016554603A JP2017510257A5 JP 2017510257 A5 JP2017510257 A5 JP 2017510257A5 JP 2016554603 A JP2016554603 A JP 2016554603A JP 2016554603 A JP2016554603 A JP 2016554603A JP 2017510257 A5 JP2017510257 A5 JP 2017510257A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- seq
- car
- cell lymphoma
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1403905.1 | 2014-03-05 | ||
| GB201403905A GB201403905D0 (en) | 2014-03-05 | 2014-03-05 | Method |
| GB1416908.0 | 2014-09-25 | ||
| GB201416908A GB201416908D0 (en) | 2014-09-25 | 2014-09-25 | Method |
| PCT/GB2015/050643 WO2015132598A1 (en) | 2014-03-05 | 2015-03-05 | Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017107689A Division JP6767931B2 (ja) | 2014-03-05 | 2017-05-31 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2020054667A Division JP7149304B2 (ja) | 2014-03-05 | 2020-03-25 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510257A JP2017510257A (ja) | 2017-04-13 |
| JP2017510257A5 true JP2017510257A5 (https=) | 2018-02-22 |
| JP6767872B2 JP6767872B2 (ja) | 2020-10-14 |
Family
ID=52649058
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016554603A Active JP6767872B2 (ja) | 2014-03-05 | 2015-03-05 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2017107689A Active JP6767931B2 (ja) | 2014-03-05 | 2017-05-31 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2020054667A Active JP7149304B2 (ja) | 2014-03-05 | 2020-03-25 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2021150189A Withdrawn JP2021184773A (ja) | 2014-03-05 | 2021-09-15 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2024060080A Pending JP2024074907A (ja) | 2014-03-05 | 2024-04-03 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017107689A Active JP6767931B2 (ja) | 2014-03-05 | 2017-05-31 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2020054667A Active JP7149304B2 (ja) | 2014-03-05 | 2020-03-25 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2021150189A Withdrawn JP2021184773A (ja) | 2014-03-05 | 2021-09-15 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
| JP2024060080A Pending JP2024074907A (ja) | 2014-03-05 | 2024-04-03 | Ｔ細胞受容体ベータ定常領域に対する抗原結合ドメインを有するキメラ抗原抗体（ｃａｒ） |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20170066827A1 (https=) |
| EP (4) | EP3241561B1 (https=) |
| JP (5) | JP6767872B2 (https=) |
| KR (3) | KR102235201B1 (https=) |
| CN (4) | CN112094353A (https=) |
| AU (3) | AU2015225944B2 (https=) |
| BR (1) | BR112016020304B1 (https=) |
| CA (1) | CA2940564C (https=) |
| CL (4) | CL2016002195A1 (https=) |
| CU (1) | CU24475B1 (https=) |
| DK (2) | DK3241561T3 (https=) |
| ES (2) | ES3033286T3 (https=) |
| FI (1) | FI3241561T3 (https=) |
| HU (2) | HUE047641T2 (https=) |
| IL (3) | IL278879B2 (https=) |
| MX (3) | MX2016010856A (https=) |
| MY (1) | MY173567A (https=) |
| PE (2) | PE20170125A1 (https=) |
| PH (3) | PH12016501646B1 (https=) |
| PL (2) | PL3241561T3 (https=) |
| PT (2) | PT3241561T (https=) |
| RU (2) | RU2021101502A (https=) |
| SG (3) | SG11201606583VA (https=) |
| WO (1) | WO2015132598A1 (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11982673B2 (en) | 2014-03-05 | 2024-05-14 | Autolus Limited | Methods |
| US11385233B2 (en) | 2015-03-05 | 2022-07-12 | Autolus Limited | Methods of depleting malignant T-cells |
| GB201403972D0 (en) | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| WO2016051205A1 (en) * | 2014-10-03 | 2016-04-07 | Isis Innovation Limited | Analysis of t-cell monotypia |
| CA2937157A1 (en) | 2016-07-25 | 2018-01-25 | Ucl Business Ltd | Protein-based t-cell receptor knockdown |
| EP3548055A4 (en) | 2016-12-02 | 2020-08-19 | University of Southern California | SYNTHETIC IMMUNE RECEPTORS AND THEIR PROCESSES FOR USE |
| AU2018219887B2 (en) | 2017-02-08 | 2024-08-15 | Dragonfly Therapeutics, LLC | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| CN110944661A (zh) | 2017-02-20 | 2020-03-31 | 蜻蜓疗法股份有限公司 | 结合her2、nkg2d和cd16的蛋白质 |
| JP6997209B2 (ja) | 2017-04-04 | 2022-02-04 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | Ｃｄ４０およびｆａｐに特異的に結合することができる新規な二重特異性抗原結合分子 |
| GB201709203D0 (en) | 2017-06-09 | 2017-07-26 | Autolus Ltd | Antigen-binding domain |
| US20210130775A1 (en) * | 2017-08-02 | 2021-05-06 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| US20200231679A1 (en) * | 2017-08-23 | 2020-07-23 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| WO2019129850A1 (en) * | 2017-12-29 | 2019-07-04 | Cellectis | Off-the-shelf engineered cells for therapy |
| EP3684399A1 (en) * | 2017-12-29 | 2020-07-29 | Cellectis | Method for improving production of car t cells |
| GB201800298D0 (en) * | 2018-01-09 | 2018-02-21 | Autolus Ltd | Method |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| WO2019143961A2 (en) * | 2018-01-19 | 2019-07-25 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting gamma delta t cells with chimeric antigen receptors |
| BR112020015994A2 (pt) | 2018-02-08 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer |
| CA3237846A1 (en) | 2018-02-08 | 2019-08-15 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the nkg2d receptor |
| WO2019164930A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| EP3765517A1 (en) | 2018-03-14 | 2021-01-20 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| WO2020010229A1 (en) * | 2018-07-06 | 2020-01-09 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Car t cell therapy to target t cell specific cancers |
| US20210277120A1 (en) * | 2018-07-18 | 2021-09-09 | The General Hospital Corporation | Compositions and methods for treatment of t cell malignancies |
| GB201812650D0 (en) | 2018-08-03 | 2018-09-19 | Autolus Ltd | Molecular assessment of TRBC usage |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE |
| KR102835308B1 (ko) | 2018-08-08 | 2025-07-21 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| GB201817172D0 (en) | 2018-10-22 | 2018-12-05 | Autolus Ltd | Antibody |
| GB201817822D0 (en) * | 2018-10-31 | 2018-12-19 | Autolus Ltd | Binding domain |
| WO2020156335A1 (zh) * | 2019-01-29 | 2020-08-06 | 上海交通大学 | 一种嵌合抗原受体及其应用 |
| GB2599228B (en) * | 2019-02-21 | 2024-02-07 | Marengo Therapeutics Inc | Multifunctional molecules that bind to T cell related cancer cells and uses thereof |
| JP7737306B2 (ja) * | 2019-02-21 | 2025-09-10 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞に結合する多機能性分子および自己免疫障害を処置するためのその使用 |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| CN110317266A (zh) * | 2019-07-17 | 2019-10-11 | 东北农业大学 | 三种scFv抗体、其编码基因及其在制备治疗或预防O型口蹄疫病制剂中的应用 |
| AU2020416273A1 (en) | 2020-01-03 | 2022-07-28 | Marengo Therapeutics, Inc. | Anti-TCR antibody molecules and uses thereof |
| EP4121518A4 (en) * | 2020-03-16 | 2024-06-19 | Marengo Therapeutics, Inc. | MODIFIED CELL COMPOSITIONS AND METHODS OF USE |
| GB202004263D0 (en) * | 2020-03-24 | 2020-05-06 | Autolus Ltd | Antibody conjugate |
| GB202005216D0 (en) | 2020-04-08 | 2020-05-20 | Autolus Ltd | Cell |
| GB202101491D0 (en) | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| US20230133554A1 (en) | 2020-04-09 | 2023-05-04 | Autolus Limited | Molecule |
| CN115843312A (zh) * | 2020-04-24 | 2023-03-24 | 马伦戈治疗公司 | 结合至t细胞相关癌细胞的多功能性分子及其用途 |
| JP7512394B2 (ja) | 2020-05-06 | 2024-07-08 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質 |
| CN111537735A (zh) * | 2020-05-15 | 2020-08-14 | 江西赛基生物技术有限公司 | 抗体检测试剂盒以及在免疫分析方面的应用 |
| CN111549044B (zh) * | 2020-07-13 | 2020-10-23 | 北京市肿瘤防治研究所 | 靶向trbc1 car-t细胞的制备方法与应用 |
| EP4200401B1 (en) * | 2020-08-18 | 2024-07-24 | Medigene Immunotherapies GmbH | Enrichment of t cells using an anti-cbeta antibody |
| GB2616354A (en) * | 2020-08-26 | 2023-09-06 | Marengo Therapeutics Inc | Methods of detecting TRBC1 or TRBC2 |
| EP4294841A1 (en) | 2021-02-17 | 2023-12-27 | The Johns Hopkins University | Methods and materials for treating clonal t cell expansions |
| WO2022177870A1 (en) * | 2021-02-17 | 2022-08-25 | The Board Of Regents Of The University Of Texas System | Multimeric sars-cov-2 binding molecules and uses thereof |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
| GB202112923D0 (en) * | 2021-09-10 | 2021-10-27 | Ucl Business Ltd | Binding domain |
| CN120076829A (zh) | 2022-10-18 | 2025-05-30 | 明治制果药业株式会社 | T细胞肿瘤的治疗剂 |
| WO2024236163A1 (en) | 2023-05-17 | 2024-11-21 | Morphosys Ag | T cell receptor beta constant region 2 (trbc2) antibodies |
| EP4727972A1 (en) * | 2023-06-14 | 2026-04-22 | Autolus Limited | Treatment of trbc1-positive t cell malignancies |
| WO2025007013A2 (en) * | 2023-06-28 | 2025-01-02 | The Johns Hopkins University | Trbc targeting antibody-drug conjugates |
| GB202310981D0 (en) | 2023-07-18 | 2023-08-30 | Autolus Ltd | Method |
| WO2025051339A1 (en) * | 2023-09-05 | 2025-03-13 | Tiber Biotech Srl | SINGLE-CHAIN VARIABLE FRAGMENT AND MOLECULES DERIVING THEREFROM THAT BIND FRAGMENT TRVB5-1 OF THE β CHAIN OF HUMAN T-CELL RECEPTOR |
| WO2025096673A1 (en) * | 2023-10-30 | 2025-05-08 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions comprising cells targeting cancer and methods of using the same |
| WO2025202622A1 (en) * | 2024-03-26 | 2025-10-02 | Oxford University Innovation Limited | Antibodies |
| CN121299112B (zh) * | 2024-09-12 | 2026-04-17 | 中国食品药品检定研究院 | 一种检测九型hpv疫苗或抗原原液体外相对效力的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69124518T2 (de) * | 1990-08-09 | 1997-05-15 | National Jewish Center For Immunology And Respiratory Medicine, Denver, Col. | Herstellung monoklonaler Antikörper gegen menschliches Vbeta T-Zellrezeptorelement unter Verwendung rekombinanter DNA-Vektoren |
| US6790604B1 (en) * | 1998-05-12 | 2004-09-14 | Stefan A. Cohen | Methods for identifying or diagnosing carcinoma cells with metastatic potential based on the measurement of lymphoid genes or their products in carcinoma cells |
| CA2484182A1 (en) * | 2002-04-29 | 2003-11-13 | Genpat77 Pharmacogenetics Ag | Novel antibody binding tcr and tirc7 and its use in therapy and diagnosis |
| RU2355703C2 (ru) * | 2002-10-09 | 2009-05-20 | Медиджен Лимитед | Одноцепочечные рекомбинантные т-клеточные рецепторы |
| GB0304068D0 (en) * | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| US7741045B2 (en) * | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| WO2009151628A2 (en) * | 2008-06-12 | 2009-12-17 | Gov't Of The Usa, As Represented By The Secretary, Department Of Health Human Services | Monitoring tcr-b to determine hiv therapy and disease progression |
| WO2010027797A1 (en) * | 2008-08-26 | 2010-03-11 | Macrogenics Inc. | T-cell receptor antibodies and methods of use thereof |
| CA2785907A1 (en) * | 2009-12-29 | 2011-07-28 | Emergent Product Development Seattle, Llc | Ron binding constructs and methods of use thereof |
| JP6000507B2 (ja) * | 2010-09-30 | 2016-09-28 | パナソニックヘルスケアホールディングス株式会社 | 診療情報登録装置 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US10391126B2 (en) * | 2011-11-18 | 2019-08-27 | Board Of Regents, The University Of Texas System | CAR+ T cells genetically modified to eliminate expression of T-cell receptor and/or HLA |
| WO2013169691A1 (en) | 2012-05-07 | 2013-11-14 | Trustees Of Dartmouth College | Anti-b7-h6 antibody, fusion proteins, and methods of using the same |
| BR112014029417B1 (pt) * | 2012-05-25 | 2023-03-07 | Cellectis | Método ex vivo para a preparação de células t para imunoterapia |
| US10443100B2 (en) * | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| JP2017529841A (ja) * | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| AU2016243583B2 (en) * | 2015-03-27 | 2022-03-10 | President And Fellows Of Harvard College | Modified T cells and methods of making and using the same |
-
2015
- 2015-03-05 DK DK17172755.5T patent/DK3241561T3/da active
- 2015-03-05 RU RU2021101502A patent/RU2021101502A/ru unknown
- 2015-03-05 IL IL278879A patent/IL278879B2/en unknown
- 2015-03-05 CN CN202010859460.5A patent/CN112094353A/zh active Pending
- 2015-03-05 PT PT171727555T patent/PT3241561T/pt unknown
- 2015-03-05 MX MX2016010856A patent/MX2016010856A/es active IP Right Grant
- 2015-03-05 HU HUE15709319A patent/HUE047641T2/hu unknown
- 2015-03-05 PL PL17172755.5T patent/PL3241561T3/pl unknown
- 2015-03-05 PH PH1/2016/501646A patent/PH12016501646B1/en unknown
- 2015-03-05 CU CU2016000129A patent/CU24475B1/es unknown
- 2015-03-05 SG SG11201606583VA patent/SG11201606583VA/en unknown
- 2015-03-05 HU HUE17172755A patent/HUE071755T2/hu unknown
- 2015-03-05 PE PE2016001548A patent/PE20170125A1/es unknown
- 2015-03-05 PE PE2021000759A patent/PE20211887A1/es unknown
- 2015-03-05 BR BR112016020304-6A patent/BR112016020304B1/pt active IP Right Grant
- 2015-03-05 KR KR1020207006444A patent/KR102235201B1/ko active Active
- 2015-03-05 PT PT157093196T patent/PT3125934T/pt unknown
- 2015-03-05 CA CA2940564A patent/CA2940564C/en active Active
- 2015-03-05 KR KR1020207006445A patent/KR102235202B1/ko active Active
- 2015-03-05 FI FIEP17172755.5T patent/FI3241561T3/fi active
- 2015-03-05 CN CN202410891896.0A patent/CN118852462A/zh active Pending
- 2015-03-05 CN CN202010858243.4A patent/CN112094347A/zh active Pending
- 2015-03-05 JP JP2016554603A patent/JP6767872B2/ja active Active
- 2015-03-05 SG SG10201906461SA patent/SG10201906461SA/en unknown
- 2015-03-05 US US15/123,287 patent/US20170066827A1/en not_active Abandoned
- 2015-03-05 CN CN201580011306.XA patent/CN106068276B/zh active Active
- 2015-03-05 EP EP17172755.5A patent/EP3241561B1/en active Active
- 2015-03-05 WO PCT/GB2015/050643 patent/WO2015132598A1/en not_active Ceased
- 2015-03-05 RU RU2016138421A patent/RU2744046C2/ru active
- 2015-03-05 AU AU2015225944A patent/AU2015225944B2/en active Active
- 2015-03-05 MY MYPI2016703188A patent/MY173567A/en unknown
- 2015-03-05 ES ES17172755T patent/ES3033286T3/es active Active
- 2015-03-05 EP EP25172928.1A patent/EP4610654A3/en active Pending
- 2015-03-05 PL PL15709319T patent/PL3125934T3/pl unknown
- 2015-03-05 DK DK15709319.6T patent/DK3125934T3/da active
- 2015-03-05 PH PH1/2020/550202A patent/PH12020550202B1/en unknown
- 2015-03-05 EP EP25222920.8A patent/EP4736887A2/en active Pending
- 2015-03-05 IL IL278878A patent/IL278878B/en unknown
- 2015-03-05 SG SG10201906460PA patent/SG10201906460PA/en unknown
- 2015-03-05 KR KR1020167027423A patent/KR102088082B1/ko active Active
- 2015-03-05 EP EP15709319.6A patent/EP3125934B1/en active Active
- 2015-03-05 ES ES15709319T patent/ES2758173T3/es active Active
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2016
- 2016-08-04 IL IL247110A patent/IL247110A0/en active IP Right Grant
- 2016-08-19 MX MX2019013845A patent/MX2019013845A/es unknown
- 2016-08-19 MX MX2019013846A patent/MX2019013846A/es unknown
- 2016-09-01 CL CL2016002195A patent/CL2016002195A1/es unknown
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2017
- 2017-05-26 US US15/606,480 patent/US20170334998A1/en not_active Abandoned
- 2017-05-31 JP JP2017107689A patent/JP6767931B2/ja active Active
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2018
- 2018-10-30 CL CL2018003096A patent/CL2018003096A1/es unknown
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2019
- 2019-06-07 CL CL2019001568A patent/CL2019001568A1/es unknown
- 2019-06-07 CL CL2019001567A patent/CL2019001567A1/es unknown
- 2019-07-09 AU AU2019204925A patent/AU2019204925B2/en active Active
- 2019-07-09 AU AU2019204921A patent/AU2019204921C1/en active Active
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2020
- 2020-03-25 JP JP2020054667A patent/JP7149304B2/ja active Active
- 2020-04-01 PH PH12020550203A patent/PH12020550203A1/en unknown
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2021
- 2021-09-15 JP JP2021150189A patent/JP2021184773A/ja not_active Withdrawn
-
2024
- 2024-04-03 JP JP2024060080A patent/JP2024074907A/ja active Pending
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